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Patent code US10376514

Compile Data Set for Download or QSAR

Found 304 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B


(Homo sapiens (Human))
BDBM289658
PNG
(6-(4-Methoxybenzyl)-9-(pyridin-2-ylmethyl)-6,8,9,1...)
Show SMILES COc1ccc(Cn2c3sc4CN(Cc5ccccn5)CCCc4c3c3ncnn3c2=O)cc1
Show InChI InChI=1S/C25H24N6O2S/c1-33-19-9-7-17(8-10-19)13-30-24-22(23-27-16-28-31(23)25(30)32)20-6-4-12-29(15-21(20)34-24)14-18-5-2-3-11-26-18/h2-3,5,7-11,16H,4,6,12-15H2,1H3
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Dart NeuroScience (Cayman) Ltd

US Patent


Assay Description
The selectivity of compounds of the present invention was determined using a panel of recombinant human PDEs and an in vitro enzymatic assay (BPS Bio...


US Patent US10376514 (2019)


BindingDB Entry DOI: 10.7270/Q2ST7S6W
More data for this
Ligand-Target Pair
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B


(Homo sapiens (Human))
BDBM289668
PNG
(6-(4-Chlorobenzyl)-9-(pyrazine-2-carbonyl)-8,9,10,...)
Show SMILES Clc1ccc(Cn2c3sc4CN(CCc4c3c3ncnn3c2=O)C(=O)c2cnccn2)cc1
Show InChI InChI=1S/C22H16ClN7O2S/c23-14-3-1-13(2-4-14)10-29-21-18(19-26-12-27-30(19)22(29)32)15-5-8-28(11-17(15)33-21)20(31)16-9-24-6-7-25-16/h1-4,6-7,9,12H,5,8,10-11H2
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Dart NeuroScience (Cayman) Ltd

US Patent


Assay Description
The selectivity of compounds of the present invention was determined using a panel of recombinant human PDEs and an in vitro enzymatic assay (BPS Bio...


US Patent US10376514 (2019)


BindingDB Entry DOI: 10.7270/Q2ST7S6W
More data for this
Ligand-Target Pair
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B


(Homo sapiens (Human))
BDBM289685
PNG
(8-(Cyclopropanecarbonyl)-6-(4-methoxybenzyl)-8,9,1...)
Show SMILES COc1ccc(Cn2c3sc4N(CCCc4c3c3ncnn3c2=O)C(=O)C2CC2)cc1
Show InChI InChI=1S/C22H21N5O3S/c1-30-15-8-4-13(5-9-15)11-26-21-17(18-23-12-24-27(18)22(26)29)16-3-2-10-25(20(16)31-21)19(28)14-6-7-14/h4-5,8-9,12,14H,2-3,6-7,10-11H2,1H3
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Dart NeuroScience (Cayman) Ltd

US Patent


Assay Description
The selectivity of compounds of the present invention was determined using a panel of recombinant human PDEs and an in vitro enzymatic assay (BPS Bio...


US Patent US10376514 (2019)


BindingDB Entry DOI: 10.7270/Q2ST7S6W
More data for this
Ligand-Target Pair
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B


(Homo sapiens (Human))
BDBM292991
PNG
(US10105367, Example 277 | US10376514, Example 277)
Show SMILES COc1ccc(Cn2c3ncc(CN4C[C@H](C)O[C@H](C)C4)cc3c3ncnn3c2=O)c(F)c1
Show InChI InChI=1S/C23H25FN6O3/c1-14-9-28(10-15(2)33-14)11-16-6-19-21(25-8-16)29(23(31)30-22(19)26-13-27-30)12-17-4-5-18(32-3)7-20(17)24/h4-8,13-15H,9-12H2,1-3H3/t14-,15+
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Dart NeuroScience (Cayman) Ltd

US Patent


Assay Description
The selectivity of compounds of the present invention was determined using a panel of recombinant human PDEs and an in vitro enzymatic assay (BPS Bio...


US Patent US10376514 (2019)


BindingDB Entry DOI: 10.7270/Q2ST7S6W
More data for this
Ligand-Target Pair
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B


(Homo sapiens (Human))
BDBM289557
PNG
(8-((Dimethylamino)methyl)-6-(4-methoxybenzyl)-9-me...)
Show SMILES COc1ccc(Cn2c3sc(CN(C)C)c(C)c3c3ncnn3c2=O)cc1
Show InChI InChI=1S/C19H21N5O2S/c1-12-15(10-22(2)3)27-18-16(12)17-20-11-21-24(17)19(25)23(18)9-13-5-7-14(26-4)8-6-13/h5-8,11H,9-10H2,1-4H3
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Dart NeuroScience (Cayman) Ltd

US Patent


Assay Description
The selectivity of compounds of the present invention was determined using a panel of recombinant human PDEs and an in vitro enzymatic assay (BPS Bio...


US Patent US10376514 (2019)


BindingDB Entry DOI: 10.7270/Q2ST7S6W
More data for this
Ligand-Target Pair
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B


(Homo sapiens (Human))
BDBM289562
PNG
(6-(4-Methoxybenzyl)-9-methyl-8-((((3-methyloxetan-...)
Show SMILES COc1ccc(Cn2c3sc(CNCC4(C)COC4)c(C)c3c3ncnn3c2=O)cc1
Show InChI InChI=1S/C22H25N5O3S/c1-14-17(8-23-10-22(2)11-30-12-22)31-20-18(14)19-24-13-25-27(19)21(28)26(20)9-15-4-6-16(29-3)7-5-15/h4-7,13,23H,8-12H2,1-3H3
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Dart NeuroScience (Cayman) Ltd

US Patent


Assay Description
The selectivity of compounds of the present invention was determined using a panel of recombinant human PDEs and an in vitro enzymatic assay (BPS Bio...


US Patent US10376514 (2019)


BindingDB Entry DOI: 10.7270/Q2ST7S6W
More data for this
Ligand-Target Pair
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B


(Homo sapiens (Human))
BDBM289567
PNG
(8-(((2S,6R)-2,6-Dimethylmorpholino)methyl)-6-(4-me...)
Show SMILES COc1ccc(Cn2c3sc(CN4C[C@H](C)O[C@H](C)C4)c(C)c3c3ncnn3c2=O)cc1
Show InChI InChI=1S/C23H27N5O3S/c1-14-9-26(10-15(2)31-14)12-19-16(3)20-21-24-13-25-28(21)23(29)27(22(20)32-19)11-17-5-7-18(30-4)8-6-17/h5-8,13-15H,9-12H2,1-4H3/t14-,15+
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Dart NeuroScience (Cayman) Ltd

US Patent


Assay Description
The selectivity of compounds of the present invention was determined using a panel of recombinant human PDEs and an in vitro enzymatic assay (BPS Bio...


US Patent US10376514 (2019)


BindingDB Entry DOI: 10.7270/Q2ST7S6W
More data for this
Ligand-Target Pair
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B


(Homo sapiens (Human))
BDBM289568
PNG
(8-(Isoindolin-2-ylmethyl)-6-(4-methoxybenzyl)-9-me...)
Show SMILES COc1ccc(Cn2c3sc(CN4Cc5ccccc5C4)c(C)c3c3ncnn3c2=O)cc1
Show InChI InChI=1S/C25H23N5O2S/c1-16-21(14-28-12-18-5-3-4-6-19(18)13-28)33-24-22(16)23-26-15-27-30(23)25(31)29(24)11-17-7-9-20(32-2)10-8-17/h3-10,15H,11-14H2,1-2H3
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Dart NeuroScience (Cayman) Ltd

US Patent


Assay Description
The selectivity of compounds of the present invention was determined using a panel of recombinant human PDEs and an in vitro enzymatic assay (BPS Bio...


US Patent US10376514 (2019)


BindingDB Entry DOI: 10.7270/Q2ST7S6W
More data for this
Ligand-Target Pair
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B


(Homo sapiens (Human))
BDBM289576
PNG
(8-((4-Isopropylpiperazin-1-yl)methyl)-6-(4-methoxy...)
Show SMILES COc1ccc(Cn2c3sc(CN4CCN(CC4)C(C)C)c(C)c3c3ncnn3c2=O)cc1
Show InChI InChI=1S/C24H30N6O2S/c1-16(2)28-11-9-27(10-12-28)14-20-17(3)21-22-25-15-26-30(22)24(31)29(23(21)33-20)13-18-5-7-19(32-4)8-6-18/h5-8,15-16H,9-14H2,1-4H3
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Dart NeuroScience (Cayman) Ltd

US Patent


Assay Description
The selectivity of compounds of the present invention was determined using a panel of recombinant human PDEs and an in vitro enzymatic assay (BPS Bio...


US Patent US10376514 (2019)


BindingDB Entry DOI: 10.7270/Q2ST7S6W
More data for this
Ligand-Target Pair
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B


(Homo sapiens (Human))
BDBM289586
PNG
(6-(4-Methoxybenzyl)-9-methyl-8-((3,3,4-trimethylpi...)
Show SMILES COc1ccc(Cn2c3sc(CN4CCN(C)C(C)(C)C4)c(C)c3c3ncnn3c2=O)cc1
Show InChI InChI=1S/C24H30N6O2S/c1-16-19(13-28-11-10-27(4)24(2,3)14-28)33-22-20(16)21-25-15-26-30(21)23(31)29(22)12-17-6-8-18(32-5)9-7-17/h6-9,15H,10-14H2,1-5H3
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Dart NeuroScience (Cayman) Ltd

US Patent


Assay Description
The selectivity of compounds of the present invention was determined using a panel of recombinant human PDEs and an in vitro enzymatic assay (BPS Bio...


US Patent US10376514 (2019)


BindingDB Entry DOI: 10.7270/Q2ST7S6W
More data for this
Ligand-Target Pair
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B


(Homo sapiens (Human))
BDBM289623
PNG
(6-(4-Methoxybenzyl)-9-((3-methyloxetan-3-yl)methyl...)
Show SMILES COc1ccc(Cn2c3sc4CN(CC5(C)COC5)CCc4c3c3ncnn3c2=O)cc1
Show InChI InChI=1S/C23H25N5O3S/c1-23(12-31-13-23)11-26-8-7-17-18(10-26)32-21-19(17)20-24-14-25-28(20)22(29)27(21)9-15-3-5-16(30-2)6-4-15/h3-6,14H,7-13H2,1-2H3
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Dart NeuroScience (Cayman) Ltd

US Patent


Assay Description
The selectivity of compounds of the present invention was determined using a panel of recombinant human PDEs and an in vitro enzymatic assay (BPS Bio...


US Patent US10376514 (2019)


BindingDB Entry DOI: 10.7270/Q2ST7S6W
More data for this
Ligand-Target Pair
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B


(Homo sapiens (Human))
BDBM289645
PNG
(6-(4-Chloro-2-fluorobenzyl)-9-((tetrahydrofuran-3-...)
Show SMILES Fc1cc(Cl)ccc1Cn1c2sc3CN(CC4CCOC4)CCc3c2c2ncnn2c1=O
Show InChI InChI=1S/C22H21ClFN5O2S/c23-15-2-1-14(17(24)7-15)9-28-21-19(20-25-12-26-29(20)22(28)30)16-3-5-27(10-18(16)32-21)8-13-4-6-31-11-13/h1-2,7,12-13H,3-6,8-11H2
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Dart NeuroScience (Cayman) Ltd

US Patent


Assay Description
The selectivity of compounds of the present invention was determined using a panel of recombinant human PDEs and an in vitro enzymatic assay (BPS Bio...


US Patent US10376514 (2019)


BindingDB Entry DOI: 10.7270/Q2ST7S6W
More data for this
Ligand-Target Pair
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B


(Homo sapiens (Human))
BDBM289655
PNG
(6-(4-Methoxybenzyl)-9-((tetrahydrofuran-3-yl)methy...)
Show SMILES COc1ccc(Cn2c3sc4CN(CC5CCOC5)CCCc4c3c3ncnn3c2=O)cc1
Show InChI InChI=1S/C24H27N5O3S/c1-31-18-6-4-16(5-7-18)12-28-23-21(22-25-15-26-29(22)24(28)30)19-3-2-9-27(13-20(19)33-23)11-17-8-10-32-14-17/h4-7,15,17H,2-3,8-14H2,1H3
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Dart NeuroScience (Cayman) Ltd

US Patent


Assay Description
The selectivity of compounds of the present invention was determined using a panel of recombinant human PDEs and an in vitro enzymatic assay (BPS Bio...


US Patent US10376514 (2019)


BindingDB Entry DOI: 10.7270/Q2ST7S6W
More data for this
Ligand-Target Pair
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B


(Homo sapiens (Human))
BDBM289657
PNG
(6-(4-Methoxybenzyl)-9-(pyrimidin-2-ylmethyl)-6,8,9...)
Show SMILES COc1ccc(Cn2c3sc4CN(Cc5ncccn5)CCCc4c3c3ncnn3c2=O)cc1
Show InChI InChI=1S/C24H23N7O2S/c1-33-17-7-5-16(6-8-17)12-30-23-21(22-27-15-28-31(22)24(30)32)18-4-2-11-29(13-19(18)34-23)14-20-25-9-3-10-26-20/h3,5-10,15H,2,4,11-14H2,1H3
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Dart NeuroScience (Cayman) Ltd

US Patent


Assay Description
The selectivity of compounds of the present invention was determined using a panel of recombinant human PDEs and an in vitro enzymatic assay (BPS Bio...


US Patent US10376514 (2019)


BindingDB Entry DOI: 10.7270/Q2ST7S6W
More data for this
Ligand-Target Pair
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B


(Homo sapiens (Human))
BDBM289659
PNG
(6-(4-Methoxybenzyl)-9-((tetrahydro-2H-pyran-4-yl)m...)
Show SMILES COc1ccc(Cn2c3sc4CN(CC5CCOCC5)CCCc4c3c3ncnn3c2=O)cc1
Show InChI InChI=1S/C25H29N5O3S/c1-32-19-6-4-17(5-7-19)14-29-24-22(23-26-16-27-30(23)25(29)31)20-3-2-10-28(15-21(20)34-24)13-18-8-11-33-12-9-18/h4-7,16,18H,2-3,8-15H2,1H3
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Dart NeuroScience (Cayman) Ltd

US Patent


Assay Description
The selectivity of compounds of the present invention was determined using a panel of recombinant human PDEs and an in vitro enzymatic assay (BPS Bio...


US Patent US10376514 (2019)


BindingDB Entry DOI: 10.7270/Q2ST7S6W
More data for this
Ligand-Target Pair
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B


(Homo sapiens (Human))
BDBM289675
PNG
(6-(4-Chloro-2-fluorobenzyl)-9-(cyclopropanecarbony...)
Show SMILES Fc1cc(Cl)ccc1Cn1c2sc3CN(CCc3c2c2ncnn2c1=O)C(=O)C1CC1
Show InChI InChI=1S/C21H17ClFN5O2S/c22-13-4-3-12(15(23)7-13)8-27-20-17(18-24-10-25-28(18)21(27)30)14-5-6-26(9-16(14)31-20)19(29)11-1-2-11/h3-4,7,10-11H,1-2,5-6,8-9H2
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Dart NeuroScience (Cayman) Ltd

US Patent


Assay Description
The selectivity of compounds of the present invention was determined using a panel of recombinant human PDEs and an in vitro enzymatic assay (BPS Bio...


US Patent US10376514 (2019)


BindingDB Entry DOI: 10.7270/Q2ST7S6W
More data for this
Ligand-Target Pair
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B


(Homo sapiens (Human))
BDBM289677
PNG
(11,11-Difluoro-6-(4-methoxybenzyl)-9-(tetrahydrofu...)
Show SMILES COc1ccc(Cn2c3sc4CN(CC(F)(F)c4c3c3ncnn3c2=O)C(=O)C2CCOC2)cc1
Show InChI InChI=1S/C23H21F2N5O4S/c1-33-15-4-2-13(3-5-15)8-29-21-17(19-26-12-27-30(19)22(29)32)18-16(35-21)9-28(11-23(18,24)25)20(31)14-6-7-34-10-14/h2-5,12,14H,6-11H2,1H3
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Dart NeuroScience (Cayman) Ltd

US Patent


Assay Description
The selectivity of compounds of the present invention was determined using a panel of recombinant human PDEs and an in vitro enzymatic assay (BPS Bio...


US Patent US10376514 (2019)


BindingDB Entry DOI: 10.7270/Q2ST7S6W
More data for this
Ligand-Target Pair
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B


(Homo sapiens (Human))
BDBM289679
PNG
(9-(Cyclopropanecarbonyl)-6-(2-fluoro-4-methoxybenz...)
Show SMILES COc1ccc(Cn2c3sc4CN(CCc4c3c3ncnn3c2=O)C(=O)C2CC2)c(F)c1
Show InChI InChI=1S/C22H20FN5O3S/c1-31-14-5-4-13(16(23)8-14)9-27-21-18(19-24-11-25-28(19)22(27)30)15-6-7-26(10-17(15)32-21)20(29)12-2-3-12/h4-5,8,11-12H,2-3,6-7,9-10H2,1H3
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Dart NeuroScience (Cayman) Ltd

US Patent


Assay Description
The selectivity of compounds of the present invention was determined using a panel of recombinant human PDEs and an in vitro enzymatic assay (BPS Bio...


US Patent US10376514 (2019)


BindingDB Entry DOI: 10.7270/Q2ST7S6W
More data for this
Ligand-Target Pair
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B


(Homo sapiens (Human))
BDBM289684
PNG
(9-(Cyclopropanecarbonyl)-6-(4-methoxybenzyl)-6,8,9...)
Show SMILES COc1ccc(Cn2c3sc4CN(CCCc4c3c3ncnn3c2=O)C(=O)C2CC2)cc1
Show InChI InChI=1S/C23H23N5O3S/c1-31-16-8-4-14(5-9-16)11-27-22-19(20-24-13-25-28(20)23(27)30)17-3-2-10-26(12-18(17)32-22)21(29)15-6-7-15/h4-5,8-9,13,15H,2-3,6-7,10-12H2,1H3
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Dart NeuroScience (Cayman) Ltd

US Patent


Assay Description
The selectivity of compounds of the present invention was determined using a panel of recombinant human PDEs and an in vitro enzymatic assay (BPS Bio...


US Patent US10376514 (2019)


BindingDB Entry DOI: 10.7270/Q2ST7S6W
More data for this
Ligand-Target Pair
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B


(Homo sapiens (Human))
BDBM292934
PNG
(US10105367, Example 220 | US10376514, Example 220)
Show SMILES COc1ccc(Cn2c3ncc(CN4C[C@H](C)O[C@H](C)C4)cc3c3ncnn3c2=O)cc1
Show InChI InChI=1S/C23H26N6O3/c1-15-10-27(11-16(2)32-15)12-18-8-20-21(24-9-18)28(23(30)29-22(20)25-14-26-29)13-17-4-6-19(31-3)7-5-17/h4-9,14-16H,10-13H2,1-3H3/t15-,16+
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Dart NeuroScience (Cayman) Ltd

US Patent


Assay Description
The selectivity of compounds of the present invention was determined using a panel of recombinant human PDEs and an in vitro enzymatic assay (BPS Bio...


US Patent US10376514 (2019)


BindingDB Entry DOI: 10.7270/Q2ST7S6W
More data for this
Ligand-Target Pair
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B


(Homo sapiens (Human))
BDBM292960
PNG
(US10105367, Example 246 | US10376514, Example 246)
Show SMILES COc1ccc(Cn2c3ncc(CN4CCN5C(COC5=O)C4)cc3c3ncnn3c2=O)cc1
Show InChI InChI=1S/C23H23N7O4/c1-33-18-4-2-15(3-5-18)11-29-20-19(21-25-14-26-30(21)22(29)31)8-16(9-24-20)10-27-6-7-28-17(12-27)13-34-23(28)32/h2-5,8-9,14,17H,6-7,10-13H2,1H3
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Dart NeuroScience (Cayman) Ltd

US Patent


Assay Description
The selectivity of compounds of the present invention was determined using a panel of recombinant human PDEs and an in vitro enzymatic assay (BPS Bio...


US Patent US10376514 (2019)


BindingDB Entry DOI: 10.7270/Q2ST7S6W
More data for this
Ligand-Target Pair
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B


(Homo sapiens (Human))
BDBM289546
PNG
(8-((4-Ethyl-3-oxopiperazin-1-yl)methyl)-6-(4-metho...)
Show SMILES CCN1CCN(Cc2cc3c4ncnn4c(=O)n(Cc4ccc(OC)cc4)c3s2)CC1=O
Show InChI InChI=1S/C22H24N6O3S/c1-3-26-9-8-25(13-19(26)29)12-17-10-18-20-23-14-24-28(20)22(30)27(21(18)32-17)11-15-4-6-16(31-2)7-5-15/h4-7,10,14H,3,8-9,11-13H2,1-2H3
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Dart NeuroScience (Cayman) Ltd

US Patent


Assay Description
The selectivity of compounds of the present invention was determined using a panel of recombinant human PDEs and an in vitro enzymatic assay (BPS Bio...


US Patent US10376514 (2019)


BindingDB Entry DOI: 10.7270/Q2ST7S6W
More data for this
Ligand-Target Pair
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B


(Homo sapiens (Human))
BDBM289549
PNG
(8-(2-Oxa-5-azabicyclo[2.2.1]heptan-5-ylmethyl)-6-(...)
Show SMILES COc1ccc(Cn2c3sc(CN4CC5CC4CO5)cc3c3ncnn3c2=O)cc1
Show InChI InChI=1S/C21H21N5O3S/c1-28-15-4-2-13(3-5-15)8-25-20-18(19-22-12-23-26(19)21(25)27)7-17(30-20)10-24-9-16-6-14(24)11-29-16/h2-5,7,12,14,16H,6,8-11H2,1H3
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Dart NeuroScience (Cayman) Ltd

US Patent


Assay Description
The selectivity of compounds of the present invention was determined using a panel of recombinant human PDEs and an in vitro enzymatic assay (BPS Bio...


US Patent US10376514 (2019)


BindingDB Entry DOI: 10.7270/Q2ST7S6W
More data for this
Ligand-Target Pair
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B


(Homo sapiens (Human))
BDBM289560
PNG
(8-((Benzyl(2-hydroxyethyl)amino)methyl)-6-(4-metho...)
Show SMILES COc1ccc(Cn2c3sc(CN(CCO)Cc4ccccc4)c(C)c3c3ncnn3c2=O)cc1
Show InChI InChI=1S/C26H27N5O3S/c1-18-22(16-29(12-13-32)14-19-6-4-3-5-7-19)35-25-23(18)24-27-17-28-31(24)26(33)30(25)15-20-8-10-21(34-2)11-9-20/h3-11,17,32H,12-16H2,1-2H3
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Dart NeuroScience (Cayman) Ltd

US Patent


Assay Description
The selectivity of compounds of the present invention was determined using a panel of recombinant human PDEs and an in vitro enzymatic assay (BPS Bio...


US Patent US10376514 (2019)


BindingDB Entry DOI: 10.7270/Q2ST7S6W
More data for this
Ligand-Target Pair
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B


(Homo sapiens (Human))
BDBM289563
PNG
(8-((4-Acetylpiperazin-1-yl)methyl)-6-(4-methoxyben...)
Show SMILES COc1ccc(Cn2c3sc(CN4CCN(CC4)C(C)=O)c(C)c3c3ncnn3c2=O)cc1
Show InChI InChI=1S/C23H26N6O3S/c1-15-19(13-26-8-10-27(11-9-26)16(2)30)33-22-20(15)21-24-14-25-29(21)23(31)28(22)12-17-4-6-18(32-3)7-5-17/h4-7,14H,8-13H2,1-3H3
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Dart NeuroScience (Cayman) Ltd

US Patent


Assay Description
The selectivity of compounds of the present invention was determined using a panel of recombinant human PDEs and an in vitro enzymatic assay (BPS Bio...


US Patent US10376514 (2019)


BindingDB Entry DOI: 10.7270/Q2ST7S6W
More data for this
Ligand-Target Pair
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B


(Homo sapiens (Human))
BDBM289582
PNG
(6-(4-Methoxybenzyl)-9-methyl-8-((2-methylmorpholin...)
Show SMILES COc1ccc(Cn2c3sc(CN4CCOC(C)C4)c(C)c3c3ncnn3c2=O)cc1
Show InChI InChI=1S/C22H25N5O3S/c1-14-10-25(8-9-30-14)12-18-15(2)19-20-23-13-24-27(20)22(28)26(21(19)31-18)11-16-4-6-17(29-3)7-5-16/h4-7,13-14H,8-12H2,1-3H3
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Dart NeuroScience (Cayman) Ltd

US Patent


Assay Description
The selectivity of compounds of the present invention was determined using a panel of recombinant human PDEs and an in vitro enzymatic assay (BPS Bio...


US Patent US10376514 (2019)


BindingDB Entry DOI: 10.7270/Q2ST7S6W
More data for this
Ligand-Target Pair
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B


(Homo sapiens (Human))
BDBM289625
PNG
(6-(4-Methoxybenzyl)-9-((tetrahydrofuran-3-yl)methy...)
Show SMILES COc1ccc(Cn2c3sc4CN(CC5CCOC5)CCc4c3c3ncnn3c2=O)cc1
Show InChI InChI=1S/C23H25N5O3S/c1-30-17-4-2-15(3-5-17)11-27-22-20(21-24-14-25-28(21)23(27)29)18-6-8-26(12-19(18)32-22)10-16-7-9-31-13-16/h2-5,14,16H,6-13H2,1H3
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Dart NeuroScience (Cayman) Ltd

US Patent


Assay Description
The selectivity of compounds of the present invention was determined using a panel of recombinant human PDEs and an in vitro enzymatic assay (BPS Bio...


US Patent US10376514 (2019)


BindingDB Entry DOI: 10.7270/Q2ST7S6W
More data for this
Ligand-Target Pair
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B


(Homo sapiens (Human))
BDBM289631
PNG
(6-(4-Methoxybenzyl)-9-(pyrimidin-4-ylmethyl)-8,9,1...)
Show SMILES COc1ccc(Cn2c3sc4CN(Cc5ccncn5)CCc4c3c3ncnn3c2=O)cc1
Show InChI InChI=1S/C23H21N7O2S/c1-32-17-4-2-15(3-5-17)10-29-22-20(21-26-14-27-30(21)23(29)31)18-7-9-28(12-19(18)33-22)11-16-6-8-24-13-25-16/h2-6,8,13-14H,7,9-12H2,1H3
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Dart NeuroScience (Cayman) Ltd

US Patent


Assay Description
The selectivity of compounds of the present invention was determined using a panel of recombinant human PDEs and an in vitro enzymatic assay (BPS Bio...


US Patent US10376514 (2019)


BindingDB Entry DOI: 10.7270/Q2ST7S6W
More data for this
Ligand-Target Pair
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B


(Homo sapiens (Human))
BDBM289638
PNG
(6-(4-Methoxybenzyl)-9-(5-oxotetrahydrofuran-2-yl)m...)
Show SMILES COc1ccc(Cn2c3sc4CN(CC5CCC(=O)O5)CCc4c3c3ncnn3c2=O)cc1
Show InChI InChI=1S/C23H23N5O4S/c1-31-15-4-2-14(3-5-15)10-27-22-20(21-24-13-25-28(21)23(27)30)17-8-9-26(12-18(17)33-22)11-16-6-7-19(29)32-16/h2-5,13,16H,6-12H2,1H3
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Dart NeuroScience (Cayman) Ltd

US Patent


Assay Description
The selectivity of compounds of the present invention was determined using a panel of recombinant human PDEs and an in vitro enzymatic assay (BPS Bio...


US Patent US10376514 (2019)


BindingDB Entry DOI: 10.7270/Q2ST7S6W
More data for this
Ligand-Target Pair
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B


(Homo sapiens (Human))
BDBM289648
PNG
(11,11-Difluoro-6-(4-methoxybenzyl)-9-((tetrahydro-...)
Show SMILES COc1ccc(Cn2c3sc4CN(CC5CCCOC5)CC(F)(F)c4c3c3ncnn3c2=O)cc1
Show InChI InChI=1S/C24H25F2N5O3S/c1-33-17-6-4-15(5-7-17)10-30-22-19(21-27-14-28-31(21)23(30)32)20-18(35-22)11-29(13-24(20,25)26)9-16-3-2-8-34-12-16/h4-7,14,16H,2-3,8-13H2,1H3
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Dart NeuroScience (Cayman) Ltd

US Patent


Assay Description
The selectivity of compounds of the present invention was determined using a panel of recombinant human PDEs and an in vitro enzymatic assay (BPS Bio...


US Patent US10376514 (2019)


BindingDB Entry DOI: 10.7270/Q2ST7S6W
More data for this
Ligand-Target Pair
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B


(Homo sapiens (Human))
BDBM289650
PNG
(6-(2-Fluoro-4-methoxybenzyl)-9-((1-methyl-1H-imida...)
Show SMILES COc1ccc(Cn2c3sc4CN(Cc5nccn5C)CCc4c3c3ncnn3c2=O)c(F)c1
Show InChI InChI=1S/C23H22FN7O2S/c1-28-8-6-25-19(28)12-29-7-5-16-18(11-29)34-22-20(16)21-26-13-27-31(21)23(32)30(22)10-14-3-4-15(33-2)9-17(14)24/h3-4,6,8-9,13H,5,7,10-12H2,1-2H3
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Dart NeuroScience (Cayman) Ltd

US Patent


Assay Description
The selectivity of compounds of the present invention was determined using a panel of recombinant human PDEs and an in vitro enzymatic assay (BPS Bio...


US Patent US10376514 (2019)


BindingDB Entry DOI: 10.7270/Q2ST7S6W
More data for this
Ligand-Target Pair
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B


(Homo sapiens (Human))
BDBM289667
PNG
(11,11-Difluoro-6-(2-fluoro-4-methoxybenzyl)-9-((te...)
Show SMILES COc1ccc(Cn2c3sc4CN(CC5CCOCC5)CC(F)(F)c4c3c3ncnn3c2=O)c(F)c1
Show InChI InChI=1S/C24H24F3N5O3S/c1-34-16-3-2-15(17(25)8-16)10-31-22-19(21-28-13-29-32(21)23(31)33)20-18(36-22)11-30(12-24(20,26)27)9-14-4-6-35-7-5-14/h2-3,8,13-14H,4-7,9-12H2,1H3
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Dart NeuroScience (Cayman) Ltd

US Patent


Assay Description
The selectivity of compounds of the present invention was determined using a panel of recombinant human PDEs and an in vitro enzymatic assay (BPS Bio...


US Patent US10376514 (2019)


BindingDB Entry DOI: 10.7270/Q2ST7S6W
More data for this
Ligand-Target Pair
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B


(Homo sapiens (Human))
BDBM289541
PNG
(8-((1,4-Oxazepan-4-yl)methyl)-6-(4-methoxybenzyl)t...)
Show SMILES COc1ccc(Cn2c3sc(CN4CCCOCC4)cc3c3ncnn3c2=O)cc1
Show InChI InChI=1S/C21H23N5O3S/c1-28-16-5-3-15(4-6-16)12-25-20-18(19-22-14-23-26(19)21(25)27)11-17(30-20)13-24-7-2-9-29-10-8-24/h3-6,11,14H,2,7-10,12-13H2,1H3
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Dart NeuroScience (Cayman) Ltd

US Patent


Assay Description
The selectivity of compounds of the present invention was determined using a panel of recombinant human PDEs and an in vitro enzymatic assay (BPS Bio...


US Patent US10376514 (2019)


BindingDB Entry DOI: 10.7270/Q2ST7S6W
More data for this
Ligand-Target Pair
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B


(Homo sapiens (Human))
BDBM289559
PNG
(8-((4-Hydroxypiperidin-1-yl)methyl)-6-(4-methoxybe...)
Show SMILES COc1ccc(Cn2c3sc(CN4CCC(O)CC4)c(C)c3c3ncnn3c2=O)cc1
Show InChI InChI=1S/C22H25N5O3S/c1-14-18(12-25-9-7-16(28)8-10-25)31-21-19(14)20-23-13-24-27(20)22(29)26(21)11-15-3-5-17(30-2)6-4-15/h3-6,13,16,28H,7-12H2,1-2H3
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Dart NeuroScience (Cayman) Ltd

US Patent


Assay Description
The selectivity of compounds of the present invention was determined using a panel of recombinant human PDEs and an in vitro enzymatic assay (BPS Bio...


US Patent US10376514 (2019)


BindingDB Entry DOI: 10.7270/Q2ST7S6W
More data for this
Ligand-Target Pair
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B


(Homo sapiens (Human))
BDBM289575
PNG
(6-(4-Methoxybenzyl)-9-methyl-8-((4-(methylsulfonyl...)
Show SMILES COc1ccc(Cn2c3sc(CN4CCN(CC4)S(C)(=O)=O)c(C)c3c3ncnn3c2=O)cc1
Show InChI InChI=1S/C22H26N6O4S2/c1-15-18(13-25-8-10-26(11-9-25)34(3,30)31)33-21-19(15)20-23-14-24-28(20)22(29)27(21)12-16-4-6-17(32-2)7-5-16/h4-7,14H,8-13H2,1-3H3
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Dart NeuroScience (Cayman) Ltd

US Patent


Assay Description
The selectivity of compounds of the present invention was determined using a panel of recombinant human PDEs and an in vitro enzymatic assay (BPS Bio...


US Patent US10376514 (2019)


BindingDB Entry DOI: 10.7270/Q2ST7S6W
More data for this
Ligand-Target Pair
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B


(Homo sapiens (Human))
BDBM289577
PNG
(8-(2-Oxa-5-azabicyclo[2.2.1]heptan-5-ylmethyl)-6-(...)
Show SMILES COc1ccc(Cn2c3sc(CN4CC5CC4CO5)c(C)c3c3ncnn3c2=O)cc1
Show InChI InChI=1S/C22H23N5O3S/c1-13-18(10-25-9-17-7-15(25)11-30-17)31-21-19(13)20-23-12-24-27(20)22(28)26(21)8-14-3-5-16(29-2)6-4-14/h3-6,12,15,17H,7-11H2,1-2H3
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Dart NeuroScience (Cayman) Ltd

US Patent


Assay Description
The selectivity of compounds of the present invention was determined using a panel of recombinant human PDEs and an in vitro enzymatic assay (BPS Bio...


US Patent US10376514 (2019)


BindingDB Entry DOI: 10.7270/Q2ST7S6W
More data for this
Ligand-Target Pair
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B


(Homo sapiens (Human))
BDBM289617
PNG
(6-(4-Chlorobenzyl)-9-((tetrahydro-2H-pyran-4-yl)me...)
Show SMILES Clc1ccc(Cn2c3sc4CN(CC5CCOCC5)CCc4c3c3ncnn3c2=O)cc1
Show InChI InChI=1S/C23H24ClN5O2S/c24-17-3-1-15(2-4-17)12-28-22-20(21-25-14-26-29(21)23(28)30)18-5-8-27(13-19(18)32-22)11-16-6-9-31-10-7-16/h1-4,14,16H,5-13H2
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Dart NeuroScience (Cayman) Ltd

US Patent


Assay Description
The selectivity of compounds of the present invention was determined using a panel of recombinant human PDEs and an in vitro enzymatic assay (BPS Bio...


US Patent US10376514 (2019)


BindingDB Entry DOI: 10.7270/Q2ST7S6W
More data for this
Ligand-Target Pair
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B


(Homo sapiens (Human))
BDBM289640
PNG
(9-(2-Fluorobenzyl)-6-(4-methoxybenzyl)-8,9,10,11-t...)
Show SMILES COc1ccc(Cn2c3sc4CN(Cc5ccccc5F)CCc4c3c3ncnn3c2=O)cc1
Show InChI InChI=1S/C25H22FN5O2S/c1-33-18-8-6-16(7-9-18)12-30-24-22(23-27-15-28-31(23)25(30)32)19-10-11-29(14-21(19)34-24)13-17-4-2-3-5-20(17)26/h2-9,15H,10-14H2,1H3
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Dart NeuroScience (Cayman) Ltd

US Patent


Assay Description
The selectivity of compounds of the present invention was determined using a panel of recombinant human PDEs and an in vitro enzymatic assay (BPS Bio...


US Patent US10376514 (2019)


BindingDB Entry DOI: 10.7270/Q2ST7S6W
More data for this
Ligand-Target Pair
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B


(Homo sapiens (Human))
BDBM289644
PNG
(6-(4-Chloro-2-fluorobenzyl)-9-(pyrimidin-2-ylmethy...)
Show SMILES Fc1cc(Cl)ccc1Cn1c2sc3CN(Cc4ncccn4)CCc3c2c2ncnn2c1=O
Show InChI InChI=1S/C22H17ClFN7OS/c23-14-3-2-13(16(24)8-14)9-30-21-19(20-27-12-28-31(20)22(30)32)15-4-7-29(10-17(15)33-21)11-18-25-5-1-6-26-18/h1-3,5-6,8,12H,4,7,9-11H2
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Dart NeuroScience (Cayman) Ltd

US Patent


Assay Description
The selectivity of compounds of the present invention was determined using a panel of recombinant human PDEs and an in vitro enzymatic assay (BPS Bio...


US Patent US10376514 (2019)


BindingDB Entry DOI: 10.7270/Q2ST7S6W
More data for this
Ligand-Target Pair
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B


(Homo sapiens (Human))
BDBM289649
PNG
(6-(2-Fluoro-4-methoxybenzyl)-9-(pyrimidin-2-ylmeth...)
Show SMILES COc1ccc(Cn2c3sc4CN(Cc5ncccn5)CCc4c3c3ncnn3c2=O)c(F)c1
Show InChI InChI=1S/C23H20FN7O2S/c1-33-15-4-3-14(17(24)9-15)10-30-22-20(21-27-13-28-31(21)23(30)32)16-5-8-29(11-18(16)34-22)12-19-25-6-2-7-26-19/h2-4,6-7,9,13H,5,8,10-12H2,1H3
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Dart NeuroScience (Cayman) Ltd

US Patent


Assay Description
The selectivity of compounds of the present invention was determined using a panel of recombinant human PDEs and an in vitro enzymatic assay (BPS Bio...


US Patent US10376514 (2019)


BindingDB Entry DOI: 10.7270/Q2ST7S6W
More data for this
Ligand-Target Pair
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B


(Homo sapiens (Human))
BDBM289654
PNG
(6-(2-Fluoro-4-methoxybenzyl)-9-((tetrahydro-2H-pyr...)
Show SMILES COc1ccc(Cn2c3sc4CN(CC5CCCOC5)CCc4c3c3ncnn3c2=O)c(F)c1
Show InChI InChI=1S/C24H26FN5O3S/c1-32-17-5-4-16(19(25)9-17)11-29-23-21(22-26-14-27-30(22)24(29)31)18-6-7-28(12-20(18)34-23)10-15-3-2-8-33-13-15/h4-5,9,14-15H,2-3,6-8,10-13H2,1H3
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Dart NeuroScience (Cayman) Ltd

US Patent


Assay Description
The selectivity of compounds of the present invention was determined using a panel of recombinant human PDEs and an in vitro enzymatic assay (BPS Bio...


US Patent US10376514 (2019)


BindingDB Entry DOI: 10.7270/Q2ST7S6W
More data for this
Ligand-Target Pair
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B


(Homo sapiens (Human))
BDBM289656
PNG
(6-(4-Methoxybenzyl)-9-((1-methyl-1H-imidazol-2-yl)...)
Show SMILES COc1ccc(Cn2c3sc4CN(Cc5nccn5C)CCCc4c3c3ncnn3c2=O)cc1
Show InChI InChI=1S/C24H25N7O2S/c1-28-11-9-25-20(28)14-29-10-3-4-18-19(13-29)34-23-21(18)22-26-15-27-31(22)24(32)30(23)12-16-5-7-17(33-2)8-6-16/h5-9,11,15H,3-4,10,12-14H2,1-2H3
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Dart NeuroScience (Cayman) Ltd

US Patent


Assay Description
The selectivity of compounds of the present invention was determined using a panel of recombinant human PDEs and an in vitro enzymatic assay (BPS Bio...


US Patent US10376514 (2019)


BindingDB Entry DOI: 10.7270/Q2ST7S6W
More data for this
Ligand-Target Pair
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B


(Homo sapiens (Human))
BDBM289672
PNG
(6-(4-Methoxybenzyl)-9-(tetrahydrofuran-3-carbonyl)...)
Show SMILES COc1ccc(Cn2c3sc4CN(CCc4c3c3ncnn3c2=O)C(=O)C2CCOC2)cc1
Show InChI InChI=1S/C23H23N5O4S/c1-31-16-4-2-14(3-5-16)10-27-22-19(20-24-13-25-28(20)23(27)30)17-6-8-26(11-18(17)33-22)21(29)15-7-9-32-12-15/h2-5,13,15H,6-12H2,1H3
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Dart NeuroScience (Cayman) Ltd

US Patent


Assay Description
The selectivity of compounds of the present invention was determined using a panel of recombinant human PDEs and an in vitro enzymatic assay (BPS Bio...


US Patent US10376514 (2019)


BindingDB Entry DOI: 10.7270/Q2ST7S6W
More data for this
Ligand-Target Pair
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B


(Homo sapiens (Human))
BDBM292943
PNG
(US10105367, Example 229 | US10376514, Example 229)
Show SMILES COc1ccc(Cn2c3ncc(CN4CCOC(C)C4)cc3c3ncnn3c2=O)cc1
Show InChI InChI=1S/C22H24N6O3/c1-15-11-26(7-8-31-15)12-17-9-19-20(23-10-17)27(22(29)28-21(19)24-14-25-28)13-16-3-5-18(30-2)6-4-16/h3-6,9-10,14-15H,7-8,11-13H2,1-2H3
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Dart NeuroScience (Cayman) Ltd

US Patent


Assay Description
The selectivity of compounds of the present invention was determined using a panel of recombinant human PDEs and an in vitro enzymatic assay (BPS Bio...


US Patent US10376514 (2019)


BindingDB Entry DOI: 10.7270/Q2ST7S6W
More data for this
Ligand-Target Pair
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B


(Homo sapiens (Human))
BDBM289556
PNG
(6-(4-Methoxybenzyl)-9-methyl-8-(morpholinomethyl)t...)
Show SMILES COc1ccc(Cn2c3sc(CN4CCOCC4)c(C)c3c3ncnn3c2=O)cc1
Show InChI InChI=1S/C21H23N5O3S/c1-14-17(12-24-7-9-29-10-8-24)30-20-18(14)19-22-13-23-26(19)21(27)25(20)11-15-3-5-16(28-2)6-4-15/h3-6,13H,7-12H2,1-2H3
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Dart NeuroScience (Cayman) Ltd

US Patent


Assay Description
The selectivity of compounds of the present invention was determined using a panel of recombinant human PDEs and an in vitro enzymatic assay (BPS Bio...


US Patent US10376514 (2019)


BindingDB Entry DOI: 10.7270/Q2ST7S6W
More data for this
Ligand-Target Pair
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B


(Homo sapiens (Human))
BDBM289558
PNG
(8-((Cyclopropyl(methyl)amino)methyl)-6-(4-methoxyb...)
Show SMILES COc1ccc(Cn2c3sc(CN(C)C4CC4)c(C)c3c3ncnn3c2=O)cc1
Show InChI InChI=1S/C21H23N5O2S/c1-13-17(11-24(2)15-6-7-15)29-20-18(13)19-22-12-23-26(19)21(27)25(20)10-14-4-8-16(28-3)9-5-14/h4-5,8-9,12,15H,6-7,10-11H2,1-3H3
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Dart NeuroScience (Cayman) Ltd

US Patent


Assay Description
The selectivity of compounds of the present invention was determined using a panel of recombinant human PDEs and an in vitro enzymatic assay (BPS Bio...


US Patent US10376514 (2019)


BindingDB Entry DOI: 10.7270/Q2ST7S6W
More data for this
Ligand-Target Pair
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B


(Homo sapiens (Human))
BDBM289574
PNG
(6-(4-Methoxybenzyl)-9-methyl-8-((4-methylpiperazin...)
Show SMILES COc1ccc(Cn2c3sc(CN4CCN(C)CC4)c(C)c3c3ncnn3c2=O)cc1
Show InChI InChI=1S/C22H26N6O2S/c1-15-18(13-26-10-8-25(2)9-11-26)31-21-19(15)20-23-14-24-28(20)22(29)27(21)12-16-4-6-17(30-3)7-5-16/h4-7,14H,8-13H2,1-3H3
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Dart NeuroScience (Cayman) Ltd

US Patent


Assay Description
The selectivity of compounds of the present invention was determined using a panel of recombinant human PDEs and an in vitro enzymatic assay (BPS Bio...


US Patent US10376514 (2019)


BindingDB Entry DOI: 10.7270/Q2ST7S6W
More data for this
Ligand-Target Pair
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B


(Homo sapiens (Human))
BDBM289592
PNG
(US10092575, Example 80 | US10376514, Example 80 | ...)
Show SMILES COc1ccc(Cn2c3sc4CN(CCc4c3c3ncnn3c2=O)C(=O)OC(C)(C)C)cc1
Show InChI InChI=1S/C23H25N5O4S/c1-23(2,3)32-22(30)26-10-9-16-17(12-26)33-20-18(16)19-24-13-25-28(19)21(29)27(20)11-14-5-7-15(31-4)8-6-14/h5-8,13H,9-12H2,1-4H3
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Dart NeuroScience (Cayman) Ltd

US Patent


Assay Description
The selectivity of compounds of the present invention was determined using a panel of recombinant human PDEs and an in vitro enzymatic assay (BPS Bio...


US Patent US10376514 (2019)


BindingDB Entry DOI: 10.7270/Q2ST7S6W
More data for this
Ligand-Target Pair
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B


(Homo sapiens (Human))
BDBM289602
PNG
(6-(4-Methoxybenzyl)-6,8,10,11-tetrahydro-5H-pyrano...)
Show SMILES COc1ccc(Cn2c3sc4COCCc4c3c3ncnn3c2=O)cc1
Show InChI InChI=1S/C18H16N4O3S/c1-24-12-4-2-11(3-5-12)8-21-17-15(13-6-7-25-9-14(13)26-17)16-19-10-20-22(16)18(21)23/h2-5,10H,6-9H2,1H3
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Dart NeuroScience (Cayman) Ltd

US Patent


Assay Description
The selectivity of compounds of the present invention was determined using a panel of recombinant human PDEs and an in vitro enzymatic assay (BPS Bio...


US Patent US10376514 (2019)


BindingDB Entry DOI: 10.7270/Q2ST7S6W
More data for this
Ligand-Target Pair
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B


(Homo sapiens (Human))
BDBM289615
PNG
(6-(4-Chlorobenzyl)-9-(cyclopropylmethyl)-8,9,10,11...)
Show SMILES Clc1ccc(Cn2c3sc4CN(CC5CC5)CCc4c3c3ncnn3c2=O)cc1
Show InChI InChI=1S/C21H20ClN5OS/c22-15-5-3-14(4-6-15)10-26-20-18(19-23-12-24-27(19)21(26)28)16-7-8-25(9-13-1-2-13)11-17(16)29-20/h3-6,12-13H,1-2,7-11H2
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Dart NeuroScience (Cayman) Ltd

US Patent


Assay Description
The selectivity of compounds of the present invention was determined using a panel of recombinant human PDEs and an in vitro enzymatic assay (BPS Bio...


US Patent US10376514 (2019)


BindingDB Entry DOI: 10.7270/Q2ST7S6W
More data for this
Ligand-Target Pair
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