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Patent code US10383880

Compile Data Set for Download or QSAR

Found 247 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Period circadian protein homolog 2


(Homo sapiens (Human))
BDBM50140895
PNG
(CHEMBL3753417 | US10383880, Example 4)
Show SMILES OC(CN(Cc1ccco1)S(=O)(=O)c1ccccc1)Cn1c2ccccc2c2ccccc12
Show InChI InChI=1S/C26H24N2O4S/c29-20(18-28-25-14-6-4-12-23(25)24-13-5-7-15-26(24)28)17-27(19-21-9-8-16-32-21)33(30,31)22-10-2-1-3-11-22/h1-16,20,29H,17-19H2
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n/an/an/an/a 2.50E+3n/an/an/an/a



Synchronicity

US Patent


Assay Description
Per2 Assay for Evaluating the Potency of Test Compounds.


US Patent US10383880 (2019)


BindingDB Entry DOI: 10.7270/Q2J67K8X
More data for this
Ligand-Target Pair
Period circadian protein homolog 2


(Homo sapiens (Human))
BDBM410795
PNG
(US10383880, Example 9)
Show SMILES COCCCS(=O)(=O)N(CC(O)Cn1c2ccccc2c2ccccc12)Cc1ccco1
Show InChI InChI=1S/C24H28N2O5S/c1-30-13-7-15-32(28,29)25(18-20-8-6-14-31-20)16-19(27)17-26-23-11-4-2-9-21(23)22-10-3-5-12-24(22)26/h2-6,8-12,14,19,27H,7,13,15-18H2,1H3
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n/an/an/an/a 2.86E+3n/an/an/an/a



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US Patent


Assay Description
Per2 Assay for Evaluating the Potency of Test Compounds.


US Patent US10383880 (2019)


BindingDB Entry DOI: 10.7270/Q2J67K8X
More data for this
Ligand-Target Pair
Period circadian protein homolog 2


(Homo sapiens (Human))
BDBM50140696
PNG
(CHEMBL3752613 | US10383880, Example 16)
Show SMILES OC(CN(Cc1ccco1)S(=O)(=O)C1CC1)Cn1c2ccccc2c2ccccc12
Show InChI InChI=1S/C23H24N2O4S/c26-17(14-24(16-18-6-5-13-29-18)30(27,28)19-11-12-19)15-25-22-9-3-1-7-20(22)21-8-2-4-10-23(21)25/h1-10,13,17,19,26H,11-12,14-16H2
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n/an/an/an/a 1.67E+3n/an/an/an/a



Synchronicity

US Patent


Assay Description
Per2 Assay for Evaluating the Potency of Test Compounds.


US Patent US10383880 (2019)


BindingDB Entry DOI: 10.7270/Q2J67K8X
More data for this
Ligand-Target Pair
Period circadian protein homolog 2


(Homo sapiens (Human))
BDBM410805
PNG
(US10383880, Example 17)
Show SMILES OC(CC(NS(=O)(=O)CC1CCOC1)c1ccco1)Cn1c2ccccc2c2ccccc12
Show InChI InChI=1S/C25H28N2O5S/c28-19(15-27-23-8-3-1-6-20(23)21-7-2-4-9-24(21)27)14-22(25-10-5-12-32-25)26-33(29,30)17-18-11-13-31-16-18/h1-10,12,18-19,22,26,28H,11,13-17H2
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n/an/an/an/a 2.49E+3n/an/an/an/a



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US Patent


Assay Description
Per2 Assay for Evaluating the Potency of Test Compounds.


US Patent US10383880 (2019)


BindingDB Entry DOI: 10.7270/Q2J67K8X
More data for this
Ligand-Target Pair
Period circadian protein homolog 2


(Homo sapiens (Human))
BDBM50140885
PNG
(CHEMBL3752453 | US10383880, Example 24)
Show SMILES CS(=O)(=O)N(CC(O)Cn1c2ccccc2c2ccccc12)c1ccc(F)cc1
Show InChI InChI=1S/C22H21FN2O3S/c1-29(27,28)25(17-12-10-16(23)11-13-17)15-18(26)14-24-21-8-4-2-6-19(21)20-7-3-5-9-22(20)24/h2-13,18,26H,14-15H2,1H3
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US Patent


Assay Description
Per2 Assay for Evaluating the Potency of Test Compounds.


US Patent US10383880 (2019)


BindingDB Entry DOI: 10.7270/Q2J67K8X
More data for this
Ligand-Target Pair
Period circadian protein homolog 2


(Homo sapiens (Human))
BDBM410819
PNG
(US10383880, Example 31)
Show SMILES CN(c1ccc(cc1)N(CC(O)Cn1c2ccccc2c2ccccc12)S(C)(=O)=O)S(=O)(=O)c1ccc(C)cc1
Show InChI InChI=1S/C30H31N3O5S2/c1-22-12-18-26(19-13-22)40(37,38)31(2)23-14-16-24(17-15-23)33(39(3,35)36)21-25(34)20-32-29-10-6-4-8-27(29)28-9-5-7-11-30(28)32/h4-19,25,34H,20-21H2,1-3H3
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n/an/an/an/a 1.40E+3n/an/an/an/a



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US Patent


Assay Description
Per2 Assay for Evaluating the Potency of Test Compounds.


US Patent US10383880 (2019)


BindingDB Entry DOI: 10.7270/Q2J67K8X
More data for this
Ligand-Target Pair
Period circadian protein homolog 2


(Homo sapiens (Human))
BDBM50140921
PNG
(CHEMBL3753693 | US10383880, Example 56)
Show SMILES CS(=O)(=O)N(CC(O)Cn1c2ccccc2c2ccccc12)C1CC1
Show InChI InChI=1S/C19H22N2O3S/c1-25(23,24)21(14-10-11-14)13-15(22)12-20-18-8-4-2-6-16(18)17-7-3-5-9-19(17)20/h2-9,14-15,22H,10-13H2,1H3
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n/an/an/an/a 128n/an/an/an/a



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US Patent


Assay Description
Per2 Assay for Evaluating the Potency of Test Compounds.


US Patent US10383880 (2019)


BindingDB Entry DOI: 10.7270/Q2J67K8X
More data for this
Ligand-Target Pair
Period circadian protein homolog 2


(Homo sapiens (Human))
BDBM410847
PNG
(US10383880, Example 60)
Show SMILES CS(=O)(=O)N(CC(O)Cn1c2ccccc2c2ccccc12)Cc1ccc(F)cc1
Show InChI InChI=1S/C23H23FN2O3S/c1-30(28,29)25(14-17-10-12-18(24)13-11-17)15-19(27)16-26-22-8-4-2-6-20(22)21-7-3-5-9-23(21)26/h2-13,19,27H,14-16H2,1H3
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n/an/an/an/a 1.22E+3n/an/an/an/a



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US Patent


Assay Description
Per2 Assay for Evaluating the Potency of Test Compounds.


US Patent US10383880 (2019)


BindingDB Entry DOI: 10.7270/Q2J67K8X
More data for this
Ligand-Target Pair
Period circadian protein homolog 2


(Homo sapiens (Human))
BDBM410850
PNG
(US10383880, Example 63)
Show SMILES Cc1cccc(c1)N(CC(O)Cn1c2ccccc2c2ccccc12)S(C)(=O)=O
Show InChI InChI=1S/C23H24N2O3S/c1-17-8-7-9-18(14-17)25(29(2,27)28)16-19(26)15-24-22-12-5-3-10-20(22)21-11-4-6-13-23(21)24/h3-14,19,26H,15-16H2,1-2H3
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US Patent


Assay Description
Per2 Assay for Evaluating the Potency of Test Compounds.


US Patent US10383880 (2019)


BindingDB Entry DOI: 10.7270/Q2J67K8X
More data for this
Ligand-Target Pair
Period circadian protein homolog 2


(Homo sapiens (Human))
BDBM410854
PNG
(US10383880, Example 67)
Show SMILES CS(=O)(=O)N(CC(O)Cn1c2ccccc2c2ccccc12)Cc1cccc(F)c1
Show InChI InChI=1S/C23H23FN2O3S/c1-30(28,29)25(14-17-7-6-8-18(24)13-17)15-19(27)16-26-22-11-4-2-9-20(22)21-10-3-5-12-23(21)26/h2-13,19,27H,14-16H2,1H3
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n/an/an/an/a 3.14E+3n/an/an/an/a



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US Patent


Assay Description
Per2 Assay for Evaluating the Potency of Test Compounds.


US Patent US10383880 (2019)


BindingDB Entry DOI: 10.7270/Q2J67K8X
More data for this
Ligand-Target Pair
Period circadian protein homolog 2


(Homo sapiens (Human))
BDBM410863
PNG
(US10383880, Example 76)
Show SMILES CS(=O)(=O)N(CC(O)Cn1c2ccccc2c2ccccc12)c1ccc2[nH]ccc2c1
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n/an/an/an/a 2.18E+3n/an/an/an/a



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US Patent


Assay Description
Per2 Assay for Evaluating the Potency of Test Compounds.


US Patent US10383880 (2019)


BindingDB Entry DOI: 10.7270/Q2J67K8X
More data for this
Ligand-Target Pair
Period circadian protein homolog 2


(Homo sapiens (Human))
BDBM410882
PNG
(US10383880, Example 95)
Show SMILES COCCN(CC(O)Cn1c2cc(F)ccc2c2ccc(F)cc12)S(C)(=O)=O
Show InChI InChI=1S/C19H22F2N2O4S/c1-27-8-7-22(28(2,25)26)11-15(24)12-23-18-9-13(20)3-5-16(18)17-6-4-14(21)10-19(17)23/h3-6,9-10,15,24H,7-8,11-12H2,1-2H3
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n/an/an/an/a 2.74E+3n/an/an/an/a



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US Patent


Assay Description
Per2 Assay for Evaluating the Potency of Test Compounds.


US Patent US10383880 (2019)


BindingDB Entry DOI: 10.7270/Q2J67K8X
More data for this
Ligand-Target Pair
Period circadian protein homolog 2


(Homo sapiens (Human))
BDBM410892
PNG
(US10383880, Example 105 | US10383880, Example 107)
Show SMILES OC(CN1CCCS1(=O)=O)Cn1c2cccc(F)c2c2c(F)cccc12
Show InChI InChI=1S/C18H18F2N2O3S/c19-13-4-1-6-15-17(13)18-14(20)5-2-7-16(18)22(15)11-12(23)10-21-8-3-9-26(21,24)25/h1-2,4-7,12,23H,3,8-11H2
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n/an/an/an/a 5.20E+3n/an/an/an/a



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US Patent


Assay Description
Per2 Assay for Evaluating the Potency of Test Compounds.


US Patent US10383880 (2019)


BindingDB Entry DOI: 10.7270/Q2J67K8X
More data for this
Ligand-Target Pair
Period circadian protein homolog 2


(Homo sapiens (Human))
BDBM410898
PNG
(US10383880, Example 111)
Show SMILES CC1CCCN(CC(O)Cn2c3ccccc3c3ccccc23)S1(=O)=O
Show InChI InChI=1S/C20H24N2O3S/c1-15-7-6-12-21(26(15,24)25)13-16(23)14-22-19-10-4-2-8-17(19)18-9-3-5-11-20(18)22/h2-5,8-11,15-16,23H,6-7,12-14H2,1H3
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US Patent


Assay Description
Per2 Assay for Evaluating the Potency of Test Compounds.


US Patent US10383880 (2019)


BindingDB Entry DOI: 10.7270/Q2J67K8X
More data for this
Ligand-Target Pair
Period circadian protein homolog 2


(Homo sapiens (Human))
BDBM410905
PNG
(US10383880, Example 118)
Show SMILES CS(=O)(=O)N(CC(O)Cn1c2ccc(F)cc2c2cc(F)ccc12)C1CC1
Show InChI InChI=1S/C19H20F2N2O3S/c1-27(25,26)23(14-4-5-14)11-15(24)10-22-18-6-2-12(20)8-16(18)17-9-13(21)3-7-19(17)22/h2-3,6-9,14-15,24H,4-5,10-11H2,1H3
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US Patent


Assay Description
Per2 Assay for Evaluating the Potency of Test Compounds.


US Patent US10383880 (2019)


BindingDB Entry DOI: 10.7270/Q2J67K8X
More data for this
Ligand-Target Pair
Period circadian protein homolog 2


(Homo sapiens (Human))
BDBM410907
PNG
(US10383880, Example 120)
Show SMILES OC(CN1CCC(F)S1(=O)=O)Cn1c2ccccc2c2ccccc12
Show InChI InChI=1S/C18H19FN2O3S/c19-18-9-10-20(25(18,23)24)11-13(22)12-21-16-7-3-1-5-14(16)15-6-2-4-8-17(15)21/h1-8,13,18,22H,9-12H2
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US Patent


Assay Description
Per2 Assay for Evaluating the Potency of Test Compounds.


US Patent US10383880 (2019)


BindingDB Entry DOI: 10.7270/Q2J67K8X
More data for this
Ligand-Target Pair
Period circadian protein homolog 2


(Homo sapiens (Human))
BDBM410908
PNG
(US10383880, Example 121)
Show SMILES OC(CN1CCCC(F)S1(=O)=O)Cn1c2ccccc2c2ccccc12
Show InChI InChI=1S/C19H21FN2O3S/c20-19-10-5-11-21(26(19,24)25)12-14(23)13-22-17-8-3-1-6-15(17)16-7-2-4-9-18(16)22/h1-4,6-9,14,19,23H,5,10-13H2
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n/an/an/an/a 51n/an/an/an/a



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US Patent


Assay Description
Per2 Assay for Evaluating the Potency of Test Compounds.


US Patent US10383880 (2019)


BindingDB Entry DOI: 10.7270/Q2J67K8X
More data for this
Ligand-Target Pair
Period circadian protein homolog 2


(Homo sapiens (Human))
BDBM410909
PNG
(US10383880, Example 122)
Show SMILES OC(CN1CCCC(F)(F)S1(=O)=O)Cn1c2ccccc2c2ccccc12
Show InChI InChI=1S/C19H20F2N2O3S/c20-19(21)10-5-11-22(27(19,25)26)12-14(24)13-23-17-8-3-1-6-15(17)16-7-2-4-9-18(16)23/h1-4,6-9,14,24H,5,10-13H2
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US Patent


Assay Description
Per2 Assay for Evaluating the Potency of Test Compounds.


US Patent US10383880 (2019)


BindingDB Entry DOI: 10.7270/Q2J67K8X
More data for this
Ligand-Target Pair
Period circadian protein homolog 2


(Homo sapiens (Human))
BDBM410930
PNG
(US10383880, Example 142)
Show SMILES CC1CCCC(C1)N(CC(O)Cn1c2ccccc2c2ccccc12)S(C)(=O)=O
Show InChI InChI=1S/C23H30N2O3S/c1-17-8-7-9-18(14-17)25(29(2,27)28)16-19(26)15-24-22-12-5-3-10-20(22)21-11-4-6-13-23(21)24/h3-6,10-13,17-19,26H,7-9,14-16H2,1-2H3
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n/an/an/an/a 813n/an/an/an/a



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US Patent


Assay Description
Per2 Assay for Evaluating the Potency of Test Compounds.


US Patent US10383880 (2019)


BindingDB Entry DOI: 10.7270/Q2J67K8X
More data for this
Ligand-Target Pair
Period circadian protein homolog 2


(Homo sapiens (Human))
BDBM410939
PNG
(US10383880, Example 151)
Show SMILES CCCN(CC(C)(O)Cn1c2ccc(F)cc2c2cc(F)ccc12)S(C)(=O)=O
Show InChI InChI=1S/C20H24F2N2O3S/c1-4-9-23(28(3,26)27)12-20(2,25)13-24-18-7-5-14(21)10-16(18)17-11-15(22)6-8-19(17)24/h5-8,10-11,25H,4,9,12-13H2,1-3H3
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n/an/an/an/a 2.26E+3n/an/an/an/a



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US Patent


Assay Description
Per2 Assay for Evaluating the Potency of Test Compounds.


US Patent US10383880 (2019)


BindingDB Entry DOI: 10.7270/Q2J67K8X
More data for this
Ligand-Target Pair
Period circadian protein homolog 2


(Homo sapiens (Human))
BDBM410949
PNG
(US10383880, Example 161)
Show SMILES CS(=O)(=O)N(CC(O)Cn1c2cc(F)ccc2c2ccc(F)cc12)C1CC1
Show InChI InChI=1S/C19H20F2N2O3S/c1-27(25,26)23(14-4-5-14)11-15(24)10-22-18-8-12(20)2-6-16(18)17-7-3-13(21)9-19(17)22/h2-3,6-9,14-15,24H,4-5,10-11H2,1H3
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n/an/an/an/a 1.14E+3n/an/an/an/a



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US Patent


Assay Description
Per2 Assay for Evaluating the Potency of Test Compounds.


US Patent US10383880 (2019)


BindingDB Entry DOI: 10.7270/Q2J67K8X
More data for this
Ligand-Target Pair
Period circadian protein homolog 2


(Homo sapiens (Human))
BDBM410961
PNG
(US10383880, Example 173)
Show SMILES CN1CCN(CC(O)Cn2c3ccc(F)cc3c3cc(F)ccc23)S(=O)(=O)C1
Show InChI InChI=1S/C19H21F2N3O3S/c1-22-6-7-23(28(26,27)12-22)10-15(25)11-24-18-4-2-13(20)8-16(18)17-9-14(21)3-5-19(17)24/h2-5,8-9,15,25H,6-7,10-12H2,1H3
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n/an/an/an/a 86n/an/an/an/a



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US Patent


Assay Description
Per2 Assay for Evaluating the Potency of Test Compounds.


US Patent US10383880 (2019)


BindingDB Entry DOI: 10.7270/Q2J67K8X
More data for this
Ligand-Target Pair
Period circadian protein homolog 2


(Homo sapiens (Human))
BDBM410964
PNG
(US10383880, Example 176)
Show SMILES CC(O)(CN1CCNCS1(=O)=O)Cn1c2ccc(F)cc2c2cc(F)ccc12
Show InChI InChI=1S/C19H21F2N3O3S/c1-19(25,10-23-7-6-22-12-28(23,26)27)11-24-17-4-2-13(20)8-15(17)16-9-14(21)3-5-18(16)24/h2-5,8-9,22,25H,6-7,10-12H2,1H3
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US Patent


Assay Description
Per2 Assay for Evaluating the Potency of Test Compounds.


US Patent US10383880 (2019)


BindingDB Entry DOI: 10.7270/Q2J67K8X
More data for this
Ligand-Target Pair
Period circadian protein homolog 2


(Homo sapiens (Human))
BDBM410980
PNG
(US10383880, Example 192)
Show SMILES CC1CCCC1N(CC(C)(O)Cn1c2ccc(F)cc2c2cc(F)ccc12)S(C)(=O)=O
Show InChI InChI=1S/C23H28F2N2O3S/c1-15-5-4-6-20(15)27(31(3,29)30)14-23(2,28)13-26-21-9-7-16(24)11-18(21)19-12-17(25)8-10-22(19)26/h7-12,15,20,28H,4-6,13-14H2,1-3H3
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US Patent


Assay Description
Per2 Assay for Evaluating the Potency of Test Compounds.


US Patent US10383880 (2019)


BindingDB Entry DOI: 10.7270/Q2J67K8X
More data for this
Ligand-Target Pair
Period circadian protein homolog 2


(Homo sapiens (Human))
BDBM410997
PNG
(US10383880, Example 207)
Show SMILES CS(=O)(=O)N(CC(O)Cn1c2ccc(F)cc2c2cc(F)ccc12)c1ccc(cc1)C1CC1
Show InChI InChI=1S/C25H24F2N2O3S/c1-33(31,32)29(20-8-4-17(5-9-20)16-2-3-16)15-21(30)14-28-24-10-6-18(26)12-22(24)23-13-19(27)7-11-25(23)28/h4-13,16,21,30H,2-3,14-15H2,1H3
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US Patent


Assay Description
Per2 Assay for Evaluating the Potency of Test Compounds.


US Patent US10383880 (2019)


BindingDB Entry DOI: 10.7270/Q2J67K8X
More data for this
Ligand-Target Pair
Period circadian protein homolog 2


(Homo sapiens (Human))
BDBM410995
PNG
(US10383880, Example 205 | US10383880, Example 212)
Show SMILES CC(C)c1ccc(cc1)N(CC(O)Cn1c2ccc(F)cc2c2cc(F)ccc12)S(C)(=O)=O
Show InChI InChI=1S/C25H26F2N2O3S/c1-16(2)17-4-8-20(9-5-17)29(33(3,31)32)15-21(30)14-28-24-10-6-18(26)12-22(24)23-13-19(27)7-11-25(23)28/h4-13,16,21,30H,14-15H2,1-3H3
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US Patent


Assay Description
Per2 Assay for Evaluating the Potency of Test Compounds.


US Patent US10383880 (2019)


BindingDB Entry DOI: 10.7270/Q2J67K8X
More data for this
Ligand-Target Pair
Period circadian protein homolog 2


(Homo sapiens (Human))
BDBM411009
PNG
(US10383880, Example 219)
Show SMILES CCN1CCN(CC(C)(O)Cn2c3ccc(F)cc3c3cc(F)ccc23)S(=O)(=O)C1
Show InChI InChI=1S/C21H25F2N3O3S/c1-3-24-8-9-25(30(28,29)14-24)12-21(2,27)13-26-19-6-4-15(22)10-17(19)18-11-16(23)5-7-20(18)26/h4-7,10-11,27H,3,8-9,12-14H2,1-2H3
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US Patent


Assay Description
Per2 Assay for Evaluating the Potency of Test Compounds.


US Patent US10383880 (2019)


BindingDB Entry DOI: 10.7270/Q2J67K8X
More data for this
Ligand-Target Pair
Period circadian protein homolog 2


(Homo sapiens (Human))
BDBM410791
PNG
(US10383880, Example 5)
Show SMILES OC(CN(Cc1ccco1)S(=O)(=O)c1cn[nH]c1)Cn1c2ccccc2c2ccccc12
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US Patent


Assay Description
Per2 Assay for Evaluating the Potency of Test Compounds.


US Patent US10383880 (2019)


BindingDB Entry DOI: 10.7270/Q2J67K8X
More data for this
Ligand-Target Pair
Period circadian protein homolog 2


(Homo sapiens (Human))
BDBM410798
PNG
(US10383880, Example 12)
Show SMILES CCOCCS(=O)(=O)N(CC(O)Cn1c2ccccc2c2ccccc12)Cc1ccco1
Show InChI InChI=1S/C24H28N2O5S/c1-2-30-14-15-32(28,29)25(18-20-8-7-13-31-20)16-19(27)17-26-23-11-5-3-9-21(23)22-10-4-6-12-24(22)26/h3-13,19,27H,2,14-18H2,1H3
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US Patent


Assay Description
Per2 Assay for Evaluating the Potency of Test Compounds.


US Patent US10383880 (2019)


BindingDB Entry DOI: 10.7270/Q2J67K8X
More data for this
Ligand-Target Pair
Period circadian protein homolog 2


(Homo sapiens (Human))
BDBM50140896
PNG
(CHEMBL3752727 | US10383880, Example 14)
Show SMILES OC(CN(Cc1ccco1)S(=O)(=O)Cc1ccccc1)Cn1c2ccccc2c2ccccc12
Show InChI InChI=1S/C27H26N2O4S/c30-22(18-29-26-14-6-4-12-24(26)25-13-5-7-15-27(25)29)17-28(19-23-11-8-16-33-23)34(31,32)20-21-9-2-1-3-10-21/h1-16,22,30H,17-20H2
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US Patent


Assay Description
Per2 Assay for Evaluating the Potency of Test Compounds.


US Patent US10383880 (2019)


BindingDB Entry DOI: 10.7270/Q2J67K8X
More data for this
Ligand-Target Pair
Period circadian protein homolog 2


(Homo sapiens (Human))
BDBM50140765
PNG
(CHEMBL1446115 | US10383880, Example 23)
Show SMILES CS(=O)(=O)N(CC(O)Cn1c2ccccc2c2ccccc12)c1ccccc1
Show InChI InChI=1S/C22H22N2O3S/c1-28(26,27)24(17-9-3-2-4-10-17)16-18(25)15-23-21-13-7-5-11-19(21)20-12-6-8-14-22(20)23/h2-14,18,25H,15-16H2,1H3
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Assay Description
Per2 Assay for Evaluating the Potency of Test Compounds.


US Patent US10383880 (2019)


BindingDB Entry DOI: 10.7270/Q2J67K8X
More data for this
Ligand-Target Pair
Period circadian protein homolog 2


(Homo sapiens (Human))
BDBM410813
PNG
(US10383880, Example 25)
Show SMILES Cc1ccc(cc1)N(CC(O)Cn1c2ccccc2c2ccccc12)S(C)(=O)=O
Show InChI InChI=1S/C23H24N2O3S/c1-17-11-13-18(14-12-17)25(29(2,27)28)16-19(26)15-24-22-9-5-3-7-20(22)21-8-4-6-10-23(21)24/h3-14,19,26H,15-16H2,1-2H3
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US Patent


Assay Description
Per2 Assay for Evaluating the Potency of Test Compounds.


US Patent US10383880 (2019)


BindingDB Entry DOI: 10.7270/Q2J67K8X
More data for this
Ligand-Target Pair
Period circadian protein homolog 2


(Homo sapiens (Human))
BDBM410814
PNG
(US10383880, Example 26)
Show SMILES CS(=O)(=O)N(CCCn1c2ccccc2c2ccccc12)c1ccccc1I
Show InChI InChI=1S/C22H21IN2O2S/c1-28(26,27)25(22-14-7-4-11-19(22)23)16-8-15-24-20-12-5-2-9-17(20)18-10-3-6-13-21(18)24/h2-7,9-14H,8,15-16H2,1H3
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US Patent


Assay Description
Per2 Assay for Evaluating the Potency of Test Compounds.


US Patent US10383880 (2019)


BindingDB Entry DOI: 10.7270/Q2J67K8X
More data for this
Ligand-Target Pair
Period circadian protein homolog 2


(Homo sapiens (Human))
BDBM50140915
PNG
(CHEMBL3754372 | US10383880, Example 45)
Show SMILES CCN(CC(O)Cn1c2ccccc2c2ccccc12)S(C)(=O)=O
Show InChI InChI=1S/C18H22N2O3S/c1-3-19(24(2,22)23)12-14(21)13-20-17-10-6-4-8-15(17)16-9-5-7-11-18(16)20/h4-11,14,21H,3,12-13H2,1-2H3
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US Patent


Assay Description
Per2 Assay for Evaluating the Potency of Test Compounds.


US Patent US10383880 (2019)


BindingDB Entry DOI: 10.7270/Q2J67K8X
More data for this
Ligand-Target Pair
Period circadian protein homolog 2


(Homo sapiens (Human))
BDBM410824
PNG
(US10383880, Example 36)
Show SMILES OC(CN1c2ccccc2CS1(=O)=O)Cn1c2ccccc2c2ccccc12
Show InChI InChI=1S/C22H20N2O3S/c25-17(14-24-20-10-4-1-7-16(20)15-28(24,26)27)13-23-21-11-5-2-8-18(21)19-9-3-6-12-22(19)23/h1-12,17,25H,13-15H2
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US Patent


Assay Description
Per2 Assay for Evaluating the Potency of Test Compounds.


US Patent US10383880 (2019)


BindingDB Entry DOI: 10.7270/Q2J67K8X
More data for this
Ligand-Target Pair
Period circadian protein homolog 2


(Homo sapiens (Human))
BDBM50140919
PNG
(CHEMBL3753078 | US10383880, Example 46)
Show SMILES CC(C)N(CC(O)Cn1c2ccccc2c2ccccc12)S(C)(=O)=O
Show InChI InChI=1S/C19H24N2O3S/c1-14(2)21(25(3,23)24)13-15(22)12-20-18-10-6-4-8-16(18)17-9-5-7-11-19(17)20/h4-11,14-15,22H,12-13H2,1-3H3
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US Patent


Assay Description
Per2 Assay for Evaluating the Potency of Test Compounds.


US Patent US10383880 (2019)


BindingDB Entry DOI: 10.7270/Q2J67K8X
More data for this
Ligand-Target Pair
Period circadian protein homolog 2


(Homo sapiens (Human))
BDBM410848
PNG
(US10383880, Example 61)
Show SMILES CS(=O)(=O)N(CC(O)Cn1c2ccccc2c2ccccc12)C1CCc2ccccc12
Show InChI InChI=1S/C25H26N2O3S/c1-31(29,30)27(25-15-14-18-8-2-3-9-20(18)25)17-19(28)16-26-23-12-6-4-10-21(23)22-11-5-7-13-24(22)26/h2-13,19,25,28H,14-17H2,1H3
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US Patent


Assay Description
Per2 Assay for Evaluating the Potency of Test Compounds.


US Patent US10383880 (2019)


BindingDB Entry DOI: 10.7270/Q2J67K8X
More data for this
Ligand-Target Pair
Period circadian protein homolog 2


(Homo sapiens (Human))
BDBM50140700
PNG
(CHEMBL3754797 | US10383880, Example 85)
Show SMILES OC(CN(Cc1ccco1)S(=O)(=O)C1CCOC1)Cn1c2ccccc2c2ccccc12
Show InChI InChI=1S/C24H26N2O5S/c27-18(15-26-23-9-3-1-7-21(23)22-8-2-4-10-24(22)26)14-25(16-19-6-5-12-31-19)32(28,29)20-11-13-30-17-20/h1-10,12,18,20,27H,11,13-17H2
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US Patent


Assay Description
Per2 Assay for Evaluating the Potency of Test Compounds.


US Patent US10383880 (2019)


BindingDB Entry DOI: 10.7270/Q2J67K8X
More data for this
Ligand-Target Pair
Period circadian protein homolog 2


(Homo sapiens (Human))
BDBM410877
PNG
(US10383880, Example 90)
Show SMILES COCCN(CC(O)Cn1c2ccc(F)cc2c2cc(F)ccc12)S(C)(=O)=O
Show InChI InChI=1S/C19H22F2N2O4S/c1-27-8-7-22(28(2,25)26)11-15(24)12-23-18-5-3-13(20)9-16(18)17-10-14(21)4-6-19(17)23/h3-6,9-10,15,24H,7-8,11-12H2,1-2H3
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US Patent


Assay Description
Per2 Assay for Evaluating the Potency of Test Compounds.


US Patent US10383880 (2019)


BindingDB Entry DOI: 10.7270/Q2J67K8X
More data for this
Ligand-Target Pair
Period circadian protein homolog 2


(Homo sapiens (Human))
BDBM410884
PNG
(US10383880, Example 97)
Show SMILES OC(CN1CCCS1(=O)=O)Cn1c2cc(F)ccc2c2c(F)cccc12
Show InChI InChI=1S/C18H18F2N2O3S/c19-12-5-6-14-17(9-12)22(16-4-1-3-15(20)18(14)16)11-13(23)10-21-7-2-8-26(21,24)25/h1,3-6,9,13,23H,2,7-8,10-11H2
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US Patent


Assay Description
Per2 Assay for Evaluating the Potency of Test Compounds.


US Patent US10383880 (2019)


BindingDB Entry DOI: 10.7270/Q2J67K8X
More data for this
Ligand-Target Pair
Period circadian protein homolog 2


(Homo sapiens (Human))
BDBM410893
PNG
(BDBM410895 | US10383880, Example 106)
Show SMILES OC(CN1CCCCS1(=O)=O)Cn1c2cccc(F)c2c2c(F)cccc12
Show InChI InChI=1S/C19H20F2N2O3S/c20-14-5-3-7-16-18(14)19-15(21)6-4-8-17(19)23(16)12-13(24)11-22-9-1-2-10-27(22,25)26/h3-8,13,24H,1-2,9-12H2
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US Patent


Assay Description
Per2 Assay for Evaluating the Potency of Test Compounds.


US Patent US10383880 (2019)


BindingDB Entry DOI: 10.7270/Q2J67K8X
More data for this
Ligand-Target Pair
Period circadian protein homolog 2


(Homo sapiens (Human))
BDBM410903
PNG
(US10383880, Example 116)
Show SMILES CC(O)(CN1CCCCS1(=O)=O)Cn1c2ccc(F)cc2c2cc(F)ccc12
Show InChI InChI=1S/C20H22F2N2O3S/c1-20(25,12-23-8-2-3-9-28(23,26)27)13-24-18-6-4-14(21)10-16(18)17-11-15(22)5-7-19(17)24/h4-7,10-11,25H,2-3,8-9,12-13H2,1H3
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US Patent


Assay Description
Per2 Assay for Evaluating the Potency of Test Compounds.


US Patent US10383880 (2019)


BindingDB Entry DOI: 10.7270/Q2J67K8X
More data for this
Ligand-Target Pair
Period circadian protein homolog 2


(Homo sapiens (Human))
BDBM410918
PNG
(US10383880, Example 131)
Show SMILES CC1CC(C1)N(CC(O)Cn1c2ccccc2c2ccccc12)S(C)(=O)=O
Show InChI InChI=1S/C21H26N2O3S/c1-15-11-16(12-15)23(27(2,25)26)14-17(24)13-22-20-9-5-3-7-18(20)19-8-4-6-10-21(19)22/h3-10,15-17,24H,11-14H2,1-2H3
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US Patent


Assay Description
Per2 Assay for Evaluating the Potency of Test Compounds.


US Patent US10383880 (2019)


BindingDB Entry DOI: 10.7270/Q2J67K8X
More data for this
Ligand-Target Pair
Period circadian protein homolog 2


(Homo sapiens (Human))
BDBM410924
PNG
(US10383880, Example 137)
Show SMILES CC1(CC1)N(CC(O)Cn1c2ccccc2c2ccccc12)S(C)(=O)=O
Show InChI InChI=1S/C20H24N2O3S/c1-20(11-12-20)22(26(2,24)25)14-15(23)13-21-18-9-5-3-7-16(18)17-8-4-6-10-19(17)21/h3-10,15,23H,11-14H2,1-2H3
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US Patent


Assay Description
Per2 Assay for Evaluating the Potency of Test Compounds.


US Patent US10383880 (2019)


BindingDB Entry DOI: 10.7270/Q2J67K8X
More data for this
Ligand-Target Pair
Period circadian protein homolog 2


(Homo sapiens (Human))
BDBM410931
PNG
(US10383880, Example 143)
Show SMILES CC1(CCCC1)N(CC(O)Cn1c2ccccc2c2ccccc12)S(C)(=O)=O
Show InChI InChI=1S/C22H28N2O3S/c1-22(13-7-8-14-22)24(28(2,26)27)16-17(25)15-23-20-11-5-3-9-18(20)19-10-4-6-12-21(19)23/h3-6,9-12,17,25H,7-8,13-16H2,1-2H3
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US Patent


Assay Description
Per2 Assay for Evaluating the Potency of Test Compounds.


US Patent US10383880 (2019)


BindingDB Entry DOI: 10.7270/Q2J67K8X
More data for this
Ligand-Target Pair
Period circadian protein homolog 2


(Homo sapiens (Human))
BDBM410951
PNG
(US10383880, Example 163)
Show SMILES CCCN(CC(O)Cn1c2ccc(F)cc2c2ccc(F)cc12)S(C)(=O)=O
Show InChI InChI=1S/C19H22F2N2O3S/c1-3-8-22(27(2,25)26)11-15(24)12-23-18-7-5-13(20)9-17(18)16-6-4-14(21)10-19(16)23/h4-7,9-10,15,24H,3,8,11-12H2,1-2H3
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US Patent


Assay Description
Per2 Assay for Evaluating the Potency of Test Compounds.


US Patent US10383880 (2019)


BindingDB Entry DOI: 10.7270/Q2J67K8X
More data for this
Ligand-Target Pair
Period circadian protein homolog 2


(Homo sapiens (Human))
BDBM410965
PNG
(US10383880, Example 177 | US10383880, Example 179)
Show SMILES CC1CCN(CC(C)(O)Cn2c3ccc(F)cc3c3cc(F)ccc23)S1(=O)=O
Show InChI InChI=1S/C20H22F2N2O3S/c1-13-7-8-23(28(13,26)27)11-20(2,25)12-24-18-5-3-14(21)9-16(18)17-10-15(22)4-6-19(17)24/h3-6,9-10,13,25H,7-8,11-12H2,1-2H3
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US Patent


Assay Description
Per2 Assay for Evaluating the Potency of Test Compounds.


US Patent US10383880 (2019)


BindingDB Entry DOI: 10.7270/Q2J67K8X
More data for this
Ligand-Target Pair
Period circadian protein homolog 2


(Homo sapiens (Human))
BDBM410972
PNG
(US10383880, Example 184)
Show SMILES CC(O)(CN1CCC(F)S1(=O)=O)Cn1c2ccc(F)cc2c2cc(F)ccc12
Show InChI InChI=1S/C19H19F3N2O3S/c1-19(25,10-23-7-6-18(22)28(23,26)27)11-24-16-4-2-12(20)8-14(16)15-9-13(21)3-5-17(15)24/h2-5,8-9,18,25H,6-7,10-11H2,1H3
PDB

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UniProtKB/SwissProt

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PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 155n/an/an/an/a



Synchronicity

US Patent


Assay Description
Per2 Assay for Evaluating the Potency of Test Compounds.


US Patent US10383880 (2019)


BindingDB Entry DOI: 10.7270/Q2J67K8X
More data for this
Ligand-Target Pair
Period circadian protein homolog 2


(Homo sapiens (Human))
BDBM410991
PNG
(US10383880, Example 201)
Show SMILES CCc1ccc(cc1)N(CC(O)Cn1c2ccc(F)cc2c2cc(F)ccc12)S(C)(=O)=O
Show InChI InChI=1S/C24H24F2N2O3S/c1-3-16-4-8-19(9-5-16)28(32(2,30)31)15-20(29)14-27-23-10-6-17(25)12-21(23)22-13-18(26)7-11-24(22)27/h4-13,20,29H,3,14-15H2,1-2H3
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PC cid
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UniChem
US Patent
n/an/an/an/a 1.57E+3n/an/an/an/a



Synchronicity

US Patent


Assay Description
Per2 Assay for Evaluating the Potency of Test Compounds.


US Patent US10383880 (2019)


BindingDB Entry DOI: 10.7270/Q2J67K8X
More data for this
Ligand-Target Pair
Period circadian protein homolog 2


(Homo sapiens (Human))
BDBM410993
PNG
(US10383880, Example 203)
Show SMILES CCCOc1ccc(cc1)N(CC(O)Cn1c2ccc(F)cc2c2cc(F)ccc12)S(C)(=O)=O
Show InChI InChI=1S/C25H26F2N2O4S/c1-3-12-33-21-8-6-19(7-9-21)29(34(2,31)32)16-20(30)15-28-24-10-4-17(26)13-22(24)23-14-18(27)5-11-25(23)28/h4-11,13-14,20,30H,3,12,15-16H2,1-2H3
PDB

Reactome pathway

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 1.77E+3n/an/an/an/a



Synchronicity

US Patent


Assay Description
Per2 Assay for Evaluating the Potency of Test Compounds.


US Patent US10383880 (2019)


BindingDB Entry DOI: 10.7270/Q2J67K8X
More data for this
Ligand-Target Pair
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* indicates data uncertainty>20%