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Patent code US10392402

Compile Data Set for Download or QSAR
Found 22 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM412136
PNG
(US10392402, Compound A | US10738007, Compound A | ...)
Show SMILES Cc1c[nH]c2nccc(Oc3c(F)cc(Nc4cc(Cl)nc(N)n4)cc3F)c12
Show InChI InChI=1S/C18H13ClF2N6O/c1-8-7-24-17-15(8)12(2-3-23-17)28-16-10(20)4-9(5-11(16)21)25-14-6-13(19)26-18(22)27-14/h2-7H,1H3,(H,23,24)(H3,22,25,26,27)
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n/an/a 2.80n/an/an/an/an/an/a



Translational Drug Development, LLC

US Patent


Assay Description
The following assay protocol is for measuring the phosphorylation of a peptide substrate (FAM-KKLRRTLSVA-OH wherein FAM is carboxyfluorescein). The p...


US Patent US10392402 (2019)


BindingDB Entry DOI: 10.7270/Q23X890M
More data for this
Ligand-Target Pair
Rho-associated protein kinase 1


(Homo sapiens (Human))
BDBM412136
PNG
(US10392402, Compound A | US10738007, Compound A | ...)
Show SMILES Cc1c[nH]c2nccc(Oc3c(F)cc(Nc4cc(Cl)nc(N)n4)cc3F)c12
Show InChI InChI=1S/C18H13ClF2N6O/c1-8-7-24-17-15(8)12(2-3-23-17)28-16-10(20)4-9(5-11(16)21)25-14-6-13(19)26-18(22)27-14/h2-7H,1H3,(H,23,24)(H3,22,25,26,27)
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n/an/a 3.30n/an/an/an/an/an/a



Translational Drug Development, LLC

US Patent


Assay Description
The following assay protocol is for measuring the phosphorylation of a peptide substrate (FAM-KKLRRTLSVA-OH wherein FAM is carboxyfluorescein). The p...


US Patent US10392402 (2019)


BindingDB Entry DOI: 10.7270/Q23X890M
More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM412135
PNG
(US10392402, Compound ID 52 | US10807966, Compound ...)
Show SMILES COc1cccc(c1)[C@@H](C)NC(=O)Nc1cc(n[nH]1)-c1ccncc1
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Translational Drug Development, LLC

US Patent


Assay Description
The following assay protocol is for measuring the phosphorylation of a peptide substrate (FAM-KKLRRTLSVA-OH wherein FAM is carboxyfluorescein). The p...


US Patent US10392402 (2019)


BindingDB Entry DOI: 10.7270/Q23X890M
More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM412127
PNG
(US10392402, Compound ID 5 | US10807966, Compound 2...)
Show SMILES COc1cccc(CNC(=O)Nc2cc([nH]n2)-c2ccncc2)c1
Show InChI InChI=1S/C17H17N5O2/c1-24-14-4-2-3-12(9-14)11-19-17(23)20-16-10-15(21-22-16)13-5-7-18-8-6-13/h2-10H,11H2,1H3,(H3,19,20,21,22,23)
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n/an/a 16.1n/an/an/an/an/an/a



Translational Drug Development, LLC

US Patent


Assay Description
The following assay protocol is for measuring the phosphorylation of a peptide substrate (FAM-KKLRRTLSVA-OH wherein FAM is carboxyfluorescein). The p...


US Patent US10392402 (2019)


BindingDB Entry DOI: 10.7270/Q23X890M
More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM412132
PNG
(US10392402, Compound ID 40 | US10807966, Compound ...)
Show SMILES COc1cccc(CNC(=O)c2cc3ccc(nc3s2)-c2cn[nH]c2)c1
Show InChI InChI=1S/C19H16N4O2S/c1-25-15-4-2-3-12(7-15)9-20-18(24)17-8-13-5-6-16(23-19(13)26-17)14-10-21-22-11-14/h2-8,10-11H,9H2,1H3,(H,20,24)(H,21,22)
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n/an/a 17.4n/an/an/an/an/an/a



Translational Drug Development, LLC

US Patent


Assay Description
The following assay protocol is for measuring the phosphorylation of a peptide substrate (FAM-KKLRRTLSVA-OH wherein FAM is carboxyfluorescein). The p...


US Patent US10392402 (2019)


BindingDB Entry DOI: 10.7270/Q23X890M
More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM412130
PNG
(US10392402, Compound ID 11 | US10807966, Compound ...)
Show SMILES COc1cccc(CN(CCN(C)C)C(=O)Nc2cc([nH]n2)-c2ccncc2)c1
Show InChI InChI=1S/C21H26N6O2/c1-26(2)11-12-27(15-16-5-4-6-18(13-16)29-3)21(28)23-20-14-19(24-25-20)17-7-9-22-10-8-17/h4-10,13-14H,11-12,15H2,1-3H3,(H2,23,24,25,28)
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n/an/a 22.1n/an/an/an/an/an/a



Translational Drug Development, LLC

US Patent


Assay Description
The following assay protocol is for measuring the phosphorylation of a peptide substrate (FAM-KKLRRTLSVA-OH wherein FAM is carboxyfluorescein). The p...


US Patent US10392402 (2019)


BindingDB Entry DOI: 10.7270/Q23X890M
More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM412128
PNG
(US10392402, Compound ID 7 | US10807966, Compound 7)
Show SMILES COc1cccc(CN(C)C(=O)Nc2cc([nH]n2)-c2ccncc2)c1
Show InChI InChI=1S/C18H19N5O2/c1-23(12-13-4-3-5-15(10-13)25-2)18(24)20-17-11-16(21-22-17)14-6-8-19-9-7-14/h3-11H,12H2,1-2H3,(H2,20,21,22,24)
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n/an/a 22.9n/an/an/an/an/an/a



Translational Drug Development, LLC

US Patent


Assay Description
The following assay protocol is for measuring the phosphorylation of a peptide substrate (FAM-KKLRRTLSVA-OH wherein FAM is carboxyfluorescein). The p...


US Patent US10392402 (2019)


BindingDB Entry DOI: 10.7270/Q23X890M
More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM412131
PNG
(US10392402, Compound ID 25)
Show SMILES COc1cccc(CNC(=O)Nc2cnn(c2)-c2ccncc2)c1
Show InChI InChI=1S/C17H17N5O2/c1-24-16-4-2-3-13(9-16)10-19-17(23)21-14-11-20-22(12-14)15-5-7-18-8-6-15/h2-9,11-12H,10H2,1H3,(H2,19,21,23)
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n/an/a 28.7n/an/an/an/an/an/a



Translational Drug Development, LLC

US Patent


Assay Description
The following assay protocol is for measuring the phosphorylation of a peptide substrate (FAM-KKLRRTLSVA-OH wherein FAM is carboxyfluorescein). The p...


US Patent US10392402 (2019)


BindingDB Entry DOI: 10.7270/Q23X890M
More data for this
Ligand-Target Pair
Rho-associated protein kinase 1


(Homo sapiens (Human))
BDBM412135
PNG
(US10392402, Compound ID 52 | US10807966, Compound ...)
Show SMILES COc1cccc(c1)[C@@H](C)NC(=O)Nc1cc(n[nH]1)-c1ccncc1
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n/an/a 34n/an/an/an/an/an/a



Translational Drug Development, LLC

US Patent


Assay Description
The following assay protocol is for measuring the phosphorylation of a peptide substrate (FAM-KKLRRTLSVA-OH wherein FAM is carboxyfluorescein). The p...


US Patent US10392402 (2019)


BindingDB Entry DOI: 10.7270/Q23X890M
More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM412129
PNG
(US10392402, Compound ID 9 | US10807966, Compound 9)
Show SMILES COc1cccc(CN(CCO)C(=O)Nc2cc([nH]n2)-c2ccncc2)c1
Show InChI InChI=1S/C19H21N5O3/c1-27-16-4-2-3-14(11-16)13-24(9-10-25)19(26)21-18-12-17(22-23-18)15-5-7-20-8-6-15/h2-8,11-12,25H,9-10,13H2,1H3,(H2,21,22,23,26)
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n/an/a 39.1n/an/an/an/an/an/a



Translational Drug Development, LLC

US Patent


Assay Description
The following assay protocol is for measuring the phosphorylation of a peptide substrate (FAM-KKLRRTLSVA-OH wherein FAM is carboxyfluorescein). The p...


US Patent US10392402 (2019)


BindingDB Entry DOI: 10.7270/Q23X890M
More data for this
Ligand-Target Pair
Rho-associated protein kinase 1


(Homo sapiens (Human))
BDBM412130
PNG
(US10392402, Compound ID 11 | US10807966, Compound ...)
Show SMILES COc1cccc(CN(CCN(C)C)C(=O)Nc2cc([nH]n2)-c2ccncc2)c1
Show InChI InChI=1S/C21H26N6O2/c1-26(2)11-12-27(15-16-5-4-6-18(13-16)29-3)21(28)23-20-14-19(24-25-20)17-7-9-22-10-8-17/h4-10,13-14H,11-12,15H2,1-3H3,(H2,23,24,25,28)
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n/an/a 63.6n/an/an/an/an/an/a



Translational Drug Development, LLC

US Patent


Assay Description
The following assay protocol is for measuring the phosphorylation of a peptide substrate (FAM-KKLRRTLSVA-OH wherein FAM is carboxyfluorescein). The p...


US Patent US10392402 (2019)


BindingDB Entry DOI: 10.7270/Q23X890M
More data for this
Ligand-Target Pair
Rho-associated protein kinase 1


(Homo sapiens (Human))
BDBM412132
PNG
(US10392402, Compound ID 40 | US10807966, Compound ...)
Show SMILES COc1cccc(CNC(=O)c2cc3ccc(nc3s2)-c2cn[nH]c2)c1
Show InChI InChI=1S/C19H16N4O2S/c1-25-15-4-2-3-12(7-15)9-20-18(24)17-8-13-5-6-16(23-19(13)26-17)14-10-21-22-11-14/h2-8,10-11H,9H2,1H3,(H,20,24)(H,21,22)
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n/an/a 65.1n/an/an/an/an/an/a



Translational Drug Development, LLC

US Patent


Assay Description
The following assay protocol is for measuring the phosphorylation of a peptide substrate (FAM-KKLRRTLSVA-OH wherein FAM is carboxyfluorescein). The p...


US Patent US10392402 (2019)


BindingDB Entry DOI: 10.7270/Q23X890M
More data for this
Ligand-Target Pair
Rho-associated protein kinase 1


(Homo sapiens (Human))
BDBM412127
PNG
(US10392402, Compound ID 5 | US10807966, Compound 2...)
Show SMILES COc1cccc(CNC(=O)Nc2cc([nH]n2)-c2ccncc2)c1
Show InChI InChI=1S/C17H17N5O2/c1-24-14-4-2-3-12(9-14)11-19-17(23)20-16-10-15(21-22-16)13-5-7-18-8-6-13/h2-10H,11H2,1H3,(H3,19,20,21,22,23)
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n/an/a 73n/an/an/an/an/an/a



Translational Drug Development, LLC

US Patent


Assay Description
The following assay protocol is for measuring the phosphorylation of a peptide substrate (FAM-KKLRRTLSVA-OH wherein FAM is carboxyfluorescein). The p...


US Patent US10392402 (2019)


BindingDB Entry DOI: 10.7270/Q23X890M
More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM412126
PNG
(US10392402, Compound ID 1)
Show SMILES OC[C@@H](NC(=O)c1cc([nH]n1)-c1ccncc1)c1cccc(F)c1
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n/an/a 98n/an/an/an/an/an/a



Translational Drug Development, LLC

US Patent


Assay Description
The following assay protocol is for measuring the phosphorylation of a peptide substrate (FAM-KKLRRTLSVA-OH wherein FAM is carboxyfluorescein). The p...


US Patent US10392402 (2019)


BindingDB Entry DOI: 10.7270/Q23X890M
More data for this
Ligand-Target Pair
Rho-associated protein kinase 1


(Homo sapiens (Human))
BDBM412128
PNG
(US10392402, Compound ID 7 | US10807966, Compound 7)
Show SMILES COc1cccc(CN(C)C(=O)Nc2cc([nH]n2)-c2ccncc2)c1
Show InChI InChI=1S/C18H19N5O2/c1-23(12-13-4-3-5-15(10-13)25-2)18(24)20-17-11-16(21-22-17)14-6-8-19-9-7-14/h3-11H,12H2,1-2H3,(H2,20,21,22,24)
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n/an/a 102n/an/an/an/an/an/a



Translational Drug Development, LLC

US Patent


Assay Description
The following assay protocol is for measuring the phosphorylation of a peptide substrate (FAM-KKLRRTLSVA-OH wherein FAM is carboxyfluorescein). The p...


US Patent US10392402 (2019)


BindingDB Entry DOI: 10.7270/Q23X890M
More data for this
Ligand-Target Pair
Rho-associated protein kinase 1


(Homo sapiens (Human))
BDBM412131
PNG
(US10392402, Compound ID 25)
Show SMILES COc1cccc(CNC(=O)Nc2cnn(c2)-c2ccncc2)c1
Show InChI InChI=1S/C17H17N5O2/c1-24-16-4-2-3-13(9-16)10-19-17(23)21-14-11-20-22(12-14)15-5-7-18-8-6-15/h2-9,11-12H,10H2,1H3,(H2,19,21,23)
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n/an/a 130n/an/an/an/an/an/a



Translational Drug Development, LLC

US Patent


Assay Description
The following assay protocol is for measuring the phosphorylation of a peptide substrate (FAM-KKLRRTLSVA-OH wherein FAM is carboxyfluorescein). The p...


US Patent US10392402 (2019)


BindingDB Entry DOI: 10.7270/Q23X890M
More data for this
Ligand-Target Pair
Rho-associated protein kinase 1


(Homo sapiens (Human))
BDBM412126
PNG
(US10392402, Compound ID 1)
Show SMILES OC[C@@H](NC(=O)c1cc([nH]n1)-c1ccncc1)c1cccc(F)c1
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n/an/a 207n/an/an/an/an/an/a



Translational Drug Development, LLC

US Patent


Assay Description
The following assay protocol is for measuring the phosphorylation of a peptide substrate (FAM-KKLRRTLSVA-OH wherein FAM is carboxyfluorescein). The p...


US Patent US10392402 (2019)


BindingDB Entry DOI: 10.7270/Q23X890M
More data for this
Ligand-Target Pair
Rho-associated protein kinase 1


(Homo sapiens (Human))
BDBM412129
PNG
(US10392402, Compound ID 9 | US10807966, Compound 9)
Show SMILES COc1cccc(CN(CCO)C(=O)Nc2cc([nH]n2)-c2ccncc2)c1
Show InChI InChI=1S/C19H21N5O3/c1-27-16-4-2-3-14(11-16)13-24(9-10-25)19(26)21-18-12-17(22-23-18)15-5-7-20-8-6-15/h2-8,11-12,25H,9-10,13H2,1H3,(H2,21,22,23,26)
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n/an/a 237n/an/an/an/an/an/a



Translational Drug Development, LLC

US Patent


Assay Description
The following assay protocol is for measuring the phosphorylation of a peptide substrate (FAM-KKLRRTLSVA-OH wherein FAM is carboxyfluorescein). The p...


US Patent US10392402 (2019)


BindingDB Entry DOI: 10.7270/Q23X890M
More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM412134
PNG
(US10392402, Compound ID 50)
Show SMILES COc1ccc(F)c(CNC(=O)Nc2cc([nH]n2)-c2ccncc2)c1
Show InChI InChI=1S/C17H16FN5O2/c1-25-13-2-3-14(18)12(8-13)10-20-17(24)21-16-9-15(22-23-16)11-4-6-19-7-5-11/h2-9H,10H2,1H3,(H3,20,21,22,23,24)
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n/an/a 239n/an/an/an/an/an/a



Translational Drug Development, LLC

US Patent


Assay Description
The following assay protocol is for measuring the phosphorylation of a peptide substrate (FAM-KKLRRTLSVA-OH wherein FAM is carboxyfluorescein). The p...


US Patent US10392402 (2019)


BindingDB Entry DOI: 10.7270/Q23X890M
More data for this
Ligand-Target Pair
Rho-associated protein kinase 1


(Homo sapiens (Human))
BDBM412134
PNG
(US10392402, Compound ID 50)
Show SMILES COc1ccc(F)c(CNC(=O)Nc2cc([nH]n2)-c2ccncc2)c1
Show InChI InChI=1S/C17H16FN5O2/c1-25-13-2-3-14(18)12(8-13)10-20-17(24)21-16-9-15(22-23-16)11-4-6-19-7-5-11/h2-9H,10H2,1H3,(H3,20,21,22,23,24)
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n/an/a 1.01E+3n/an/an/an/an/an/a



Translational Drug Development, LLC

US Patent


Assay Description
The following assay protocol is for measuring the phosphorylation of a peptide substrate (FAM-KKLRRTLSVA-OH wherein FAM is carboxyfluorescein). The p...


US Patent US10392402 (2019)


BindingDB Entry DOI: 10.7270/Q23X890M
More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM412133
PNG
(US10392402, Compound ID 48)
Show SMILES COc1cccc(CNC(=O)Nc2cc([nH]n2)-c2ccncc2)c1F
Show InChI InChI=1S/C17H16FN5O2/c1-25-14-4-2-3-12(16(14)18)10-20-17(24)21-15-9-13(22-23-15)11-5-7-19-8-6-11/h2-9H,10H2,1H3,(H3,20,21,22,23,24)
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n/an/a 1.87E+3n/an/an/an/an/an/a



Translational Drug Development, LLC

US Patent


Assay Description
The following assay protocol is for measuring the phosphorylation of a peptide substrate (FAM-KKLRRTLSVA-OH wherein FAM is carboxyfluorescein). The p...


US Patent US10392402 (2019)


BindingDB Entry DOI: 10.7270/Q23X890M
More data for this
Ligand-Target Pair
Rho-associated protein kinase 1


(Homo sapiens (Human))
BDBM412133
PNG
(US10392402, Compound ID 48)
Show SMILES COc1cccc(CNC(=O)Nc2cc([nH]n2)-c2ccncc2)c1F
Show InChI InChI=1S/C17H16FN5O2/c1-25-14-4-2-3-12(16(14)18)10-20-17(24)21-15-9-13(22-23-15)11-5-7-19-8-6-11/h2-9H,10H2,1H3,(H3,20,21,22,23,24)
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n/an/a 6.40E+3n/an/an/an/an/an/a



Translational Drug Development, LLC

US Patent


Assay Description
The following assay protocol is for measuring the phosphorylation of a peptide substrate (FAM-KKLRRTLSVA-OH wherein FAM is carboxyfluorescein). The p...


US Patent US10392402 (2019)


BindingDB Entry DOI: 10.7270/Q23X890M
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%