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Patent code US10392405

Compile Data Set for Download or QSAR
Found 25 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Programmed cell death 1 ligand 1


(Homo sapiens (Human))
BDBM412159
PNG
(US10392405, Compound Id 1.023)
Show SMILES Cc1c(COc2cc3OCc4cc(cc(c4)C(=O)NCCCC[C@H](NCc3cc2Cl)C(O)=O)C#N)cccc1-c1cccc(OCCCN2CC[C@@H](O)C2)c1C
Show InChI InChI=1S/C44H49ClN4O7/c1-28-32(8-5-9-36(28)37-10-6-12-40(29(37)2)54-17-7-15-49-16-13-35(50)25-49)27-56-42-22-41-34(21-38(42)45)24-48-39(44(52)53)11-3-4-14-47-43(51)33-19-30(23-46)18-31(20-33)26-55-41/h5-6,8-10,12,18-22,35,39,48,50H,3-4,7,11,13-17,24-27H2,1-2H3,(H,47,51)(H,52,53)/t35-,39+/m1/s1
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ChemoCentryx, Inc.

US Patent


Assay Description
96 Well plates were coated with 1 μg/mL of human PD-L1 (obtained from R&D) in PBS overnight at 4 C. The wells were then blocked with 2% BSA in ...


US Patent US10392405 (2019)


BindingDB Entry DOI: 10.7270/Q2057J9N
More data for this
Ligand-Target Pair
Programmed cell death 1 ligand 1


(Homo sapiens (Human))
BDBM412156
PNG
(US10392405, Compound Id 1.020)
Show SMILES Cc1c(COc2cc3OCc4cncc(c4)C(=O)NCCCC[C@H](NCc3cc2Cl)C(O)=O)cccc1-c1cccc(OCCCN2CC(O)C2)c1C
Show InChI InChI=1S/C41H47ClN4O7/c1-26-29(8-5-9-33(26)34-10-6-12-37(27(34)2)51-15-7-14-46-22-32(47)23-46)25-53-39-18-38-30(17-35(39)42)21-45-36(41(49)50)11-3-4-13-44-40(48)31-16-28(24-52-38)19-43-20-31/h5-6,8-10,12,16-20,32,36,45,47H,3-4,7,11,13-15,21-25H2,1-2H3,(H,44,48)(H,49,50)/t36-/m0/s1
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ChemoCentryx, Inc.

US Patent


Assay Description
96 Well plates were coated with 1 μg/mL of human PD-L1 (obtained from R&D) in PBS overnight at 4 C. The wells were then blocked with 2% BSA in ...


US Patent US10392405 (2019)


BindingDB Entry DOI: 10.7270/Q2057J9N
More data for this
Ligand-Target Pair
Programmed cell death 1 ligand 1


(Homo sapiens (Human))
BDBM412152
PNG
(US10392405, Compound Id 1.016)
Show SMILES Cc1c(COc2cc3OCc4cncc(c4)C(=O)NCCCC[C@H](NCc3cc2Cl)C(O)=O)cccc1-c1ccccc1
Show InChI InChI=1S/C34H34ClN3O5/c1-22-25(10-7-11-28(22)24-8-3-2-4-9-24)21-43-32-16-31-26(15-29(32)35)19-38-30(34(40)41)12-5-6-13-37-33(39)27-14-23(20-42-31)17-36-18-27/h2-4,7-11,14-18,30,38H,5-6,12-13,19-21H2,1H3,(H,37,39)(H,40,41)/t30-/m0/s1
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ChemoCentryx, Inc.

US Patent


Assay Description
96 Well plates were coated with 1 μg/mL of human PD-L1 (obtained from R&D) in PBS overnight at 4 C. The wells were then blocked with 2% BSA in ...


US Patent US10392405 (2019)


BindingDB Entry DOI: 10.7270/Q2057J9N
More data for this
Ligand-Target Pair
Programmed cell death 1 ligand 1


(Homo sapiens (Human))
BDBM412157
PNG
(US10392405, Compound Id 1.021)
Show SMILES Cc1c(COc2cc3OCc4cc(cc(c4)C(=O)NCCCC[C@H](NCc3cc2Cl)C(O)=O)C#N)cccc1-c1cccc(OCCCN2CCC(F)CC2)c1C
Show InChI InChI=1S/C45H50ClFN4O6/c1-29-33(8-5-9-37(29)38-10-6-12-41(30(38)2)55-19-7-16-51-17-13-36(47)14-18-51)28-57-43-24-42-35(23-39(43)46)26-50-40(45(53)54)11-3-4-15-49-44(52)34-21-31(25-48)20-32(22-34)27-56-42/h5-6,8-10,12,20-24,36,40,50H,3-4,7,11,13-19,26-28H2,1-2H3,(H,49,52)(H,53,54)/t40-/m0/s1
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ChemoCentryx, Inc.

US Patent


Assay Description
96 Well plates were coated with 1 μg/mL of human PD-L1 (obtained from R&D) in PBS overnight at 4 C. The wells were then blocked with 2% BSA in ...


US Patent US10392405 (2019)


BindingDB Entry DOI: 10.7270/Q2057J9N
More data for this
Ligand-Target Pair
Programmed cell death 1 ligand 1


(Homo sapiens (Human))
BDBM412150
PNG
(US10392405, Compound Id 1.014)
Show SMILES OC(=O)[C@@H]1CCCCNC(=O)c2cncc(COc3cc(O[C@H]4CCc5c4cccc5-c4ccc5OCCOc5c4F)c(Cl)cc3CN1)c2
Show InChI InChI=1S/C37H35ClFN3O7/c38-28-15-22-19-42-29(37(44)45)6-1-2-11-41-36(43)23-14-21(17-40-18-23)20-48-32(22)16-33(28)49-30-9-7-25-24(4-3-5-26(25)30)27-8-10-31-35(34(27)39)47-13-12-46-31/h3-5,8,10,14-18,29-30,42H,1-2,6-7,9,11-13,19-20H2,(H,41,43)(H,44,45)/t29-,30-/m0/s1
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ChemoCentryx, Inc.

US Patent


Assay Description
96 Well plates were coated with 1 μg/mL of human PD-L1 (obtained from R&D) in PBS overnight at 4 C. The wells were then blocked with 2% BSA in ...


US Patent US10392405 (2019)


BindingDB Entry DOI: 10.7270/Q2057J9N
More data for this
Ligand-Target Pair
Programmed cell death 1 ligand 1


(Homo sapiens (Human))
BDBM412138
PNG
(US10392405, Compound Id 1.002)
Show SMILES Cc1c(COc2cc3OCc4cncc(c4)C(=O)NCCCC[C@H](NCc3cc2Cl)C(O)=O)cccc1-c1ccc2OCCOc2c1
Show InChI InChI=1S/C36H36ClN3O7/c1-22-25(5-4-6-28(22)24-8-9-31-34(15-24)45-12-11-44-31)21-47-33-16-32-26(14-29(33)37)19-40-30(36(42)43)7-2-3-10-39-35(41)27-13-23(20-46-32)17-38-18-27/h4-6,8-9,13-18,30,40H,2-3,7,10-12,19-21H2,1H3,(H,39,41)(H,42,43)/t30-/m0/s1
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ChemoCentryx, Inc.

US Patent


Assay Description
96 Well plates were coated with 1 μg/mL of human PD-L1 (obtained from R&D) in PBS overnight at 4 C. The wells were then blocked with 2% BSA in ...


US Patent US10392405 (2019)


BindingDB Entry DOI: 10.7270/Q2057J9N
More data for this
Ligand-Target Pair
Programmed cell death 1 ligand 1


(Homo sapiens (Human))
BDBM412139
PNG
(US10392405, Compound Id 1.003)
Show SMILES Cc1c(COc2cc3OCc4cncc(c4)C(=O)NCCCC[C@H](NCc3cc2Cl)C(O)=O)cccc1-c1ccccc1F
Show InChI InChI=1S/C34H33ClFN3O5/c1-21-23(7-6-9-26(21)27-8-2-3-10-29(27)36)20-44-32-15-31-24(14-28(32)35)18-39-30(34(41)42)11-4-5-12-38-33(40)25-13-22(19-43-31)16-37-17-25/h2-3,6-10,13-17,30,39H,4-5,11-12,18-20H2,1H3,(H,38,40)(H,41,42)/t30-/m0/s1
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ChemoCentryx, Inc.

US Patent


Assay Description
96 Well plates were coated with 1 μg/mL of human PD-L1 (obtained from R&D) in PBS overnight at 4 C. The wells were then blocked with 2% BSA in ...


US Patent US10392405 (2019)


BindingDB Entry DOI: 10.7270/Q2057J9N
More data for this
Ligand-Target Pair
Programmed cell death 1 ligand 1


(Homo sapiens (Human))
BDBM412160
PNG
(US10392405, Compound Id 1.024)
Show SMILES Cc1c(COc2cc3OCc4cncc(c4)C(=O)NCCCC[C@@H](CO)NCc3cc2Cl)cccc1-c1cccc(OCCCN2CC[C@@H](O)C2)c1C
Show InChI InChI=1S/C42H51ClN4O6/c1-28-31(8-5-10-36(28)37-11-6-12-39(29(37)2)51-17-7-15-47-16-13-35(49)24-47)27-53-41-20-40-32(19-38(41)43)23-46-34(25-48)9-3-4-14-45-42(50)33-18-30(26-52-40)21-44-22-33/h5-6,8,10-12,18-22,34-35,46,48-49H,3-4,7,9,13-17,23-27H2,1-2H3,(H,45,50)/t34-,35+/m0/s1
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ChemoCentryx, Inc.

US Patent


Assay Description
96 Well plates were coated with 1 μg/mL of human PD-L1 (obtained from R&D) in PBS overnight at 4 C. The wells were then blocked with 2% BSA in ...


US Patent US10392405 (2019)


BindingDB Entry DOI: 10.7270/Q2057J9N
More data for this
Ligand-Target Pair
Programmed cell death 1 ligand 1


(Homo sapiens (Human))
BDBM412153
PNG
(US10392405, Compound Id 1.017)
Show SMILES Cc1c(COc2cc3OCc4cncc(c4)C(=O)NCCCC[C@@H](CO)NCc3cc2Cl)cccc1-c1cccc(OCCCN2CCC(O)CC2)c1C
Show InChI InChI=1S/C43H53ClN4O6/c1-29-32(8-5-10-37(29)38-11-6-12-40(30(38)2)52-19-7-16-48-17-13-36(50)14-18-48)28-54-42-22-41-33(21-39(42)44)25-47-35(26-49)9-3-4-15-46-43(51)34-20-31(27-53-41)23-45-24-34/h5-6,8,10-12,20-24,35-36,47,49-50H,3-4,7,9,13-19,25-28H2,1-2H3,(H,46,51)/t35-/m0/s1
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ChemoCentryx, Inc.

US Patent


Assay Description
96 Well plates were coated with 1 μg/mL of human PD-L1 (obtained from R&D) in PBS overnight at 4 C. The wells were then blocked with 2% BSA in ...


US Patent US10392405 (2019)


BindingDB Entry DOI: 10.7270/Q2057J9N
More data for this
Ligand-Target Pair
Programmed cell death 1 ligand 1


(Homo sapiens (Human))
BDBM412158
PNG
(US10392405, Compound Id 1.022)
Show SMILES Cc1c(COc2cc3OCc4cc(cc(c4)C(=O)NCCCC[C@H](NCc3cc2Cl)C(O)=O)C#N)cccc1-c1cccc(OCCCN2CCC(O)CC2)c1C
Show InChI InChI=1S/C45H51ClN4O7/c1-29-33(8-5-9-37(29)38-10-6-12-41(30(38)2)55-19-7-16-50-17-13-36(51)14-18-50)28-57-43-24-42-35(23-39(43)46)26-49-40(45(53)54)11-3-4-15-48-44(52)34-21-31(25-47)20-32(22-34)27-56-42/h5-6,8-10,12,20-24,36,40,49,51H,3-4,7,11,13-19,26-28H2,1-2H3,(H,48,52)(H,53,54)/t40-/m0/s1
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ChemoCentryx, Inc.

US Patent


Assay Description
96 Well plates were coated with 1 μg/mL of human PD-L1 (obtained from R&D) in PBS overnight at 4 C. The wells were then blocked with 2% BSA in ...


US Patent US10392405 (2019)


BindingDB Entry DOI: 10.7270/Q2057J9N
More data for this
Ligand-Target Pair
Programmed cell death 1 ligand 1


(Homo sapiens (Human))
BDBM412161
PNG
(US10392405, Compound Id 1.025)
Show SMILES Cc1c(COc2cc3OCc4cncc(c4)C(=O)NCCCC[C@@H](CO)NCc3cc2Cl)cccc1-c1cccc(OCCCN2CCC(F)CC2)c1C
Show InChI InChI=1S/C43H52ClFN4O5/c1-29-32(8-5-10-37(29)38-11-6-12-40(30(38)2)52-19-7-16-49-17-13-35(45)14-18-49)28-54-42-22-41-33(21-39(42)44)25-48-36(26-50)9-3-4-15-47-43(51)34-20-31(27-53-41)23-46-24-34/h5-6,8,10-12,20-24,35-36,48,50H,3-4,7,9,13-19,25-28H2,1-2H3,(H,47,51)/t36-/m0/s1
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ChemoCentryx, Inc.

US Patent


Assay Description
96 Well plates were coated with 1 μg/mL of human PD-L1 (obtained from R&D) in PBS overnight at 4 C. The wells were then blocked with 2% BSA in ...


US Patent US10392405 (2019)


BindingDB Entry DOI: 10.7270/Q2057J9N
More data for this
Ligand-Target Pair
Programmed cell death 1 ligand 1


(Homo sapiens (Human))
BDBM412140
PNG
(US10392405, Compound Id 1.004)
Show SMILES Cc1c(COc2cc3OCc4cncc(c4)C(=O)NCCCC[C@H](NCc3cc2Cl)C(O)=O)cccc1-c1cccc(OCCCN2CCC(O)CC2)c1C
Show InChI InChI=1S/C43H51ClN4O7/c1-28-31(8-5-9-35(28)36-10-6-12-39(29(36)2)53-19-7-16-48-17-13-34(49)14-18-48)27-55-41-22-40-32(21-37(41)44)25-47-38(43(51)52)11-3-4-15-46-42(50)33-20-30(26-54-40)23-45-24-33/h5-6,8-10,12,20-24,34,38,47,49H,3-4,7,11,13-19,25-27H2,1-2H3,(H,46,50)(H,51,52)/t38-/m0/s1
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ChemoCentryx, Inc.

US Patent


Assay Description
96 Well plates were coated with 1 μg/mL of human PD-L1 (obtained from R&D) in PBS overnight at 4 C. The wells were then blocked with 2% BSA in ...


US Patent US10392405 (2019)


BindingDB Entry DOI: 10.7270/Q2057J9N
More data for this
Ligand-Target Pair
Programmed cell death 1 ligand 1


(Homo sapiens (Human))
BDBM412137
PNG
(US10392405, Compound Id 1.001)
Show SMILES COc1cccc(c1F)-c1cccc(COc2cc3OCc4cncc(c4)C(=O)NCCCC[C@H](NCc3cc2Cl)C(O)=O)c1C
Show InChI InChI=1S/C35H35ClFN3O6/c1-21-23(7-5-8-26(21)27-9-6-11-30(44-2)33(27)37)20-46-32-15-31-24(14-28(32)36)18-40-29(35(42)43)10-3-4-12-39-34(41)25-13-22(19-45-31)16-38-17-25/h5-9,11,13-17,29,40H,3-4,10,12,18-20H2,1-2H3,(H,39,41)(H,42,43)/t29-/m0/s1
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ChemoCentryx, Inc.

US Patent


Assay Description
96 Well plates were coated with 1 μg/mL of human PD-L1 (obtained from R&D) in PBS overnight at 4 C. The wells were then blocked with 2% BSA in ...


US Patent US10392405 (2019)


BindingDB Entry DOI: 10.7270/Q2057J9N
More data for this
Ligand-Target Pair
Programmed cell death 1 ligand 1


(Homo sapiens (Human))
BDBM412151
PNG
(US10392405, Compound Id 1.015)
Show SMILES Cc1c(COc2cc3OCc4cncc(c4)C(=O)NCCCC[C@@H](NCc3cc2Cl)C(O)=O)cccc1-c1ccccc1
Show InChI InChI=1S/C34H34ClN3O5/c1-22-25(10-7-11-28(22)24-8-3-2-4-9-24)21-43-32-16-31-26(15-29(32)35)19-38-30(34(40)41)12-5-6-13-37-33(39)27-14-23(20-42-31)17-36-18-27/h2-4,7-11,14-18,30,38H,5-6,12-13,19-21H2,1H3,(H,37,39)(H,40,41)/t30-/m1/s1
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ChemoCentryx, Inc.

US Patent


Assay Description
96 Well plates were coated with 1 μg/mL of human PD-L1 (obtained from R&D) in PBS overnight at 4 C. The wells were then blocked with 2% BSA in ...


US Patent US10392405 (2019)


BindingDB Entry DOI: 10.7270/Q2057J9N
More data for this
Ligand-Target Pair
Programmed cell death 1 ligand 1


(Homo sapiens (Human))
BDBM412155
PNG
(US10392405, Compound Id 1.019)
Show SMILES Cc1c(COc2cc3OCc4cncc(c4)C(=O)NCCCCCC[C@H](NCc3cc2Cl)C(O)=O)cccc1-c1cccc(OCCCN2CCC(O)CC2)c1C
Show InChI InChI=1S/C45H55ClN4O7/c1-30-33(10-7-11-37(30)38-12-8-14-41(31(38)2)55-21-9-18-50-19-15-36(51)16-20-50)29-57-43-24-42-34(23-39(43)46)27-49-40(45(53)54)13-5-3-4-6-17-48-44(52)35-22-32(28-56-42)25-47-26-35/h7-8,10-12,14,22-26,36,40,49,51H,3-6,9,13,15-21,27-29H2,1-2H3,(H,48,52)(H,53,54)/t40-/m0/s1
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ChemoCentryx, Inc.

US Patent


Assay Description
96 Well plates were coated with 1 μg/mL of human PD-L1 (obtained from R&D) in PBS overnight at 4 C. The wells were then blocked with 2% BSA in ...


US Patent US10392405 (2019)


BindingDB Entry DOI: 10.7270/Q2057J9N
More data for this
Ligand-Target Pair
Programmed cell death 1 ligand 1


(Homo sapiens (Human))
BDBM412154
PNG
(US10392405, Compound Id 1.018)
Show SMILES Cc1c(COc2cc3OCc4cncc(c4)C(=O)NCCCC[C@H](NCc3cc2Cl)C(O)=O)cccc1-c1cccc(OCCCN2CC[C@@H](O)C2)c1C
Show InChI InChI=1S/C42H49ClN4O7/c1-27-30(8-5-9-34(27)35-10-6-12-38(28(35)2)52-17-7-15-47-16-13-33(48)24-47)26-54-40-20-39-31(19-36(40)43)23-46-37(42(50)51)11-3-4-14-45-41(49)32-18-29(25-53-39)21-44-22-32/h5-6,8-10,12,18-22,33,37,46,48H,3-4,7,11,13-17,23-26H2,1-2H3,(H,45,49)(H,50,51)/t33-,37+/m1/s1
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ChemoCentryx, Inc.

US Patent


Assay Description
96 Well plates were coated with 1 μg/mL of human PD-L1 (obtained from R&D) in PBS overnight at 4 C. The wells were then blocked with 2% BSA in ...


US Patent US10392405 (2019)


BindingDB Entry DOI: 10.7270/Q2057J9N
More data for this
Ligand-Target Pair
Programmed cell death 1 ligand 1


(Homo sapiens (Human))
BDBM412148
PNG
(US10392405, Compound Id 1.012)
Show SMILES Cc1c(COc2cc3OCCCCC(=O)NCCCC[C@H](NCc3cc2Cl)C(O)=O)cccc1-c1ccccc1
Show InChI InChI=1S/C32H37ClN2O5/c1-22-24(12-9-13-26(22)23-10-3-2-4-11-23)21-40-30-19-29-25(18-27(30)33)20-35-28(32(37)38)14-5-7-16-34-31(36)15-6-8-17-39-29/h2-4,9-13,18-19,28,35H,5-8,14-17,20-21H2,1H3,(H,34,36)(H,37,38)/t28-/m0/s1
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n/an/a 300n/an/an/an/an/an/a



ChemoCentryx, Inc.

US Patent


Assay Description
96 Well plates were coated with 1 μg/mL of human PD-L1 (obtained from R&D) in PBS overnight at 4 C. The wells were then blocked with 2% BSA in ...


US Patent US10392405 (2019)


BindingDB Entry DOI: 10.7270/Q2057J9N
More data for this
Ligand-Target Pair
Programmed cell death 1 ligand 1


(Homo sapiens (Human))
BDBM412147
PNG
(US10392405, Compound Id 1.011)
Show SMILES Cc1c(COc2cc3OCc4cncc(c4)C(=O)NCCCC[C@@H](CC(O)=O)NCc3cc2Cl)cccc1-c1ccccc1
Show InChI InChI=1S/C35H36ClN3O5/c1-23-26(10-7-12-30(23)25-8-3-2-4-9-25)22-44-33-17-32-27(15-31(33)36)20-39-29(16-34(40)41)11-5-6-13-38-35(42)28-14-24(21-43-32)18-37-19-28/h2-4,7-10,12,14-15,17-19,29,39H,5-6,11,13,16,20-22H2,1H3,(H,38,42)(H,40,41)/t29-/m0/s1
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n/an/a 300n/an/an/an/an/an/a



ChemoCentryx, Inc.

US Patent


Assay Description
96 Well plates were coated with 1 μg/mL of human PD-L1 (obtained from R&D) in PBS overnight at 4 C. The wells were then blocked with 2% BSA in ...


US Patent US10392405 (2019)


BindingDB Entry DOI: 10.7270/Q2057J9N
More data for this
Ligand-Target Pair
Programmed cell death 1 ligand 1


(Homo sapiens (Human))
BDBM412146
PNG
(US10392405, Compound Id 1.010)
Show SMILES Cc1c(COc2cc3OCc4cncc(c4)C(=O)NCCC[C@H](NCc3cc2Cl)C(O)=O)cccc1-c1ccccc1
Show InChI InChI=1S/C33H32ClN3O5/c1-21-24(9-5-10-27(21)23-7-3-2-4-8-23)20-42-31-15-30-25(14-28(31)34)18-37-29(33(39)40)11-6-12-36-32(38)26-13-22(19-41-30)16-35-17-26/h2-5,7-10,13-17,29,37H,6,11-12,18-20H2,1H3,(H,36,38)(H,39,40)/t29-/m0/s1
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n/an/a 300n/an/an/an/an/an/a



ChemoCentryx, Inc.

US Patent


Assay Description
96 Well plates were coated with 1 μg/mL of human PD-L1 (obtained from R&D) in PBS overnight at 4 C. The wells were then blocked with 2% BSA in ...


US Patent US10392405 (2019)


BindingDB Entry DOI: 10.7270/Q2057J9N
More data for this
Ligand-Target Pair
Programmed cell death 1 ligand 1


(Homo sapiens (Human))
BDBM412143
PNG
(US10392405, Compound Id 1.007)
Show SMILES OC(=O)[C@@H]1CCCCNC(=O)c2cncc(COc3cc(O[C@H]4CCc5c4cccc5-c4ccccc4F)c(Cl)cc3CN1)c2
Show InChI InChI=1S/C35H33ClFN3O5/c36-28-15-22-19-40-30(35(42)43)10-3-4-13-39-34(41)23-14-21(17-38-18-23)20-44-32(22)16-33(28)45-31-12-11-25-24(7-5-8-27(25)31)26-6-1-2-9-29(26)37/h1-2,5-9,14-18,30-31,40H,3-4,10-13,19-20H2,(H,39,41)(H,42,43)/t30-,31-/m0/s1
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n/an/a 300n/an/an/an/an/an/a



ChemoCentryx, Inc.

US Patent


Assay Description
96 Well plates were coated with 1 μg/mL of human PD-L1 (obtained from R&D) in PBS overnight at 4 C. The wells were then blocked with 2% BSA in ...


US Patent US10392405 (2019)


BindingDB Entry DOI: 10.7270/Q2057J9N
More data for this
Ligand-Target Pair
Programmed cell death 1 ligand 1


(Homo sapiens (Human))
BDBM412144
PNG
(US10392405, Compound Id 1.008)
Show SMILES Cc1c(COc2cc3OCc4cncc(c4)C(=O)NCCOC[C@H](NCc3cc2Cl)C(O)=O)cccc1-c1ccccc1
Show InChI InChI=1S/C33H32ClN3O6/c1-21-24(8-5-9-27(21)23-6-3-2-4-7-23)19-43-31-14-30-25(13-28(31)34)17-37-29(33(39)40)20-41-11-10-36-32(38)26-12-22(18-42-30)15-35-16-26/h2-9,12-16,29,37H,10-11,17-20H2,1H3,(H,36,38)(H,39,40)/t29-/m0/s1
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n/an/a 300n/an/an/an/an/an/a



ChemoCentryx, Inc.

US Patent


Assay Description
96 Well plates were coated with 1 μg/mL of human PD-L1 (obtained from R&D) in PBS overnight at 4 C. The wells were then blocked with 2% BSA in ...


US Patent US10392405 (2019)


BindingDB Entry DOI: 10.7270/Q2057J9N
More data for this
Ligand-Target Pair
Programmed cell death 1 ligand 1


(Homo sapiens (Human))
BDBM412142
PNG
(US10392405, Compound Id 1.006)
Show SMILES Cc1c(COc2cc3OCc4cncc(c4)C(=O)NCCNC(=O)[C@H](CO)NCc3cc2Cl)cccc1-c1ccccc1
Show InChI InChI=1S/C33H33ClN4O5/c1-21-24(8-5-9-27(21)23-6-3-2-4-7-23)20-43-31-14-30-25(13-28(31)34)17-38-29(18-39)33(41)37-11-10-36-32(40)26-12-22(19-42-30)15-35-16-26/h2-9,12-16,29,38-39H,10-11,17-20H2,1H3,(H,36,40)(H,37,41)/t29-/m0/s1
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ChemoCentryx, Inc.

US Patent


Assay Description
96 Well plates were coated with 1 μg/mL of human PD-L1 (obtained from R&D) in PBS overnight at 4 C. The wells were then blocked with 2% BSA in ...


US Patent US10392405 (2019)


BindingDB Entry DOI: 10.7270/Q2057J9N
More data for this
Ligand-Target Pair
Programmed cell death 1 ligand 1


(Homo sapiens (Human))
BDBM412141
PNG
(US10392405, Compound Id 1.005)
Show SMILES Cc1c(COc2cc3OCc4cncc(c4)C(=O)NCCCC[C@H](NCc3cc2Cl)C(O)=O)cccc1-c1cccc(OCCCCl)c1C
Show InChI InChI=1S/C38H41Cl2N3O6/c1-24-27(8-5-9-30(24)31-10-6-12-34(25(31)2)47-15-7-13-39)23-49-36-18-35-28(17-32(36)40)21-43-33(38(45)46)11-3-4-14-42-37(44)29-16-26(22-48-35)19-41-20-29/h5-6,8-10,12,16-20,33,43H,3-4,7,11,13-15,21-23H2,1-2H3,(H,42,44)(H,45,46)/t33-/m0/s1
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n/an/a 1.03E+4n/an/an/an/an/an/a



ChemoCentryx, Inc.

US Patent


Assay Description
96 Well plates were coated with 1 μg/mL of human PD-L1 (obtained from R&D) in PBS overnight at 4 C. The wells were then blocked with 2% BSA in ...


US Patent US10392405 (2019)


BindingDB Entry DOI: 10.7270/Q2057J9N
More data for this
Ligand-Target Pair
Programmed cell death 1 ligand 1


(Homo sapiens (Human))
BDBM412145
PNG
(US10392405, Compound Id 1.009)
Show SMILES Cc1c(COc2cc3OCc4cncc(c4)C(=O)NCC[C@H](NCc3cc2Cl)C(O)=O)cccc1-c1ccccc1
Show InChI InChI=1S/C32H30ClN3O5/c1-20-23(8-5-9-26(20)22-6-3-2-4-7-22)19-41-30-14-29-24(13-27(30)33)17-36-28(32(38)39)10-11-35-31(37)25-12-21(18-40-29)15-34-16-25/h2-9,12-16,28,36H,10-11,17-19H2,1H3,(H,35,37)(H,38,39)/t28-/m0/s1
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n/an/a 1.03E+4n/an/an/an/an/an/a



ChemoCentryx, Inc.

US Patent


Assay Description
96 Well plates were coated with 1 μg/mL of human PD-L1 (obtained from R&D) in PBS overnight at 4 C. The wells were then blocked with 2% BSA in ...


US Patent US10392405 (2019)


BindingDB Entry DOI: 10.7270/Q2057J9N
More data for this
Ligand-Target Pair
Programmed cell death 1 ligand 1


(Homo sapiens (Human))
BDBM412149
PNG
(US10392405, Compound Id 1.013)
Show SMILES Cc1c(COc2cc-3c(CN[C@@H](CCCCNC(=O)c4cncc-3c4)C(O)=O)cc2Cl)cccc1-c1ccccc1
Show InChI InChI=1S/C33H32ClN3O4/c1-21-23(10-7-11-27(21)22-8-3-2-4-9-22)20-41-31-16-28-24-14-26(18-35-17-24)32(38)36-13-6-5-12-30(33(39)40)37-19-25(28)15-29(31)34/h2-4,7-11,14-18,30,37H,5-6,12-13,19-20H2,1H3,(H,36,38)(H,39,40)/t30-/m0/s1
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n/an/a 1.03E+4n/an/an/an/an/an/a



ChemoCentryx, Inc.

US Patent


Assay Description
96 Well plates were coated with 1 μg/mL of human PD-L1 (obtained from R&D) in PBS overnight at 4 C. The wells were then blocked with 2% BSA in ...


US Patent US10392405 (2019)


BindingDB Entry DOI: 10.7270/Q2057J9N
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%