Compile Data Set for Download or QSAR
maximum 50k data
Found 108 Enz. Inhib. hit(s) with all data for entry = 8668
TargetBaculoviral IAP repeat-containing protein 2 [260-351](Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM412181((S)-N-(2-(((S)-3-((2,6- difluorophenyl)carbamoyl)-...)
Affinity DataIC50:  2nMAssay Description:For the Bir3 assay, 25.5 nanomolar BIR3 domain, corresponding to amino acids 260-352 of cIAP, was mixed with 41 nM of the peptide AVPIAQKSEK-(ε-...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetBaculoviral IAP repeat-containing protein 2 [260-351](Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM412169((3S)-N-[2-[[(3S)-3-[(2,6- difluorophenyl)carbamoyl...)
Affinity DataIC50:  2nMAssay Description:For the Bir3 assay, 25.5 nanomolar BIR3 domain, corresponding to amino acids 260-352 of cIAP, was mixed with 41 nM of the peptide AVPIAQKSEK-(ε-...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetBaculoviral IAP repeat-containing protein 2 [260-351](Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM412176(US10398702, Example 15 | tert-Butyl (2R,5S)-4-[2-[...)
Affinity DataIC50:  2nMAssay Description:For the Bir3 assay, 25.5 nanomolar BIR3 domain, corresponding to amino acids 260-352 of cIAP, was mixed with 41 nM of the peptide AVPIAQKSEK-(ε-...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetE3 ubiquitin-protein ligase XIAP [124-240](Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM412169((3S)-N-[2-[[(3S)-3-[(2,6- difluorophenyl)carbamoyl...)
Affinity DataIC50:  2nMAssay Description:For the Bir2 assay, 3.5 nanomolar of 6× Histidine-tagged BIR2 domain (6× Histidine disclosed as SEQ ID NO: 25), corresponding to amino acids 124-240 ...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetBaculoviral IAP repeat-containing protein 2 [260-351](Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM412178(US10398702, Example 17 | tert-Butyl N-[(1 S)-2-[[(...)
Affinity DataIC50:  2nMAssay Description:For the Bir3 assay, 25.5 nanomolar BIR3 domain, corresponding to amino acids 260-352 of cIAP, was mixed with 41 nM of the peptide AVPIAQKSEK-(ε-...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetBaculoviral IAP repeat-containing protein 2 [260-351](Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM412171((3S)-2-[(2S)-3,3-dimethyl- 2-[[(2S)-2- (methylamin...)
Affinity DataIC50:  2nMAssay Description:For the Bir3 assay, 25.5 nanomolar BIR3 domain, corresponding to amino acids 260-352 of cIAP, was mixed with 41 nM of the peptide AVPIAQKSEK-(ε-...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetE3 ubiquitin-protein ligase XIAP [241-356](Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM412171((3S)-2-[(2S)-3,3-dimethyl- 2-[[(2S)-2- (methylamin...)
Affinity DataIC50:  2nMAssay Description:For the Bir3 assay, 13.3 nanomolar BIR3 domain, corresponding to amino acids 241-356 of XIAP, was mixed with 25.2 nM of the peptide AVPIAQKSEK-(ε...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetE3 ubiquitin-protein ligase XIAP [241-356](Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM412164(US10398702, Example 3 | tert-Butyl (2R,5S)-4-[2-[3...)
Affinity DataIC50:  3nMAssay Description:For the Bir3 assay, 13.3 nanomolar BIR3 domain, corresponding to amino acids 241-356 of XIAP, was mixed with 25.2 nM of the peptide AVPIAQKSEK-(ε...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetBaculoviral IAP repeat-containing protein 2 [260-351](Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM412183(US10398702, Example 22 | tert-Butyl (2R,5S)-4-[2-[...)
Affinity DataIC50:  3nMAssay Description:For the Bir3 assay, 25.5 nanomolar BIR3 domain, corresponding to amino acids 260-352 of cIAP, was mixed with 41 nM of the peptide AVPIAQKSEK-(ε-...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetE3 ubiquitin-protein ligase XIAP [124-240](Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM412173((R)-N-((S)-3-((2,6- difluorophenyl)carbamoyl)- 2-(...)
Affinity DataIC50:  3nMAssay Description:For the Bir2 assay, 3.5 nanomolar of 6× Histidine-tagged BIR2 domain (6× Histidine disclosed as SEQ ID NO: 25), corresponding to amino acids 124-240 ...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetE3 ubiquitin-protein ligase XIAP [124-240](Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM412183(US10398702, Example 22 | tert-Butyl (2R,5S)-4-[2-[...)
Affinity DataIC50:  3nMAssay Description:For the Bir2 assay, 3.5 nanomolar of 6× Histidine-tagged BIR2 domain (6× Histidine disclosed as SEQ ID NO: 25), corresponding to amino acids 124-240 ...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetBaculoviral IAP repeat-containing protein 2 [260-351](Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM412182(US10398702, Example 21 | tert-Butyl (2R,5S)-4-[2-[...)
Affinity DataIC50:  3nMAssay Description:For the Bir3 assay, 25.5 nanomolar BIR3 domain, corresponding to amino acids 260-352 of cIAP, was mixed with 41 nM of the peptide AVPIAQKSEK-(ε-...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetBaculoviral IAP repeat-containing protein 2 [260-351](Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM412180(US10398702, Example 19 | tert-Butyl (2R,5S)-4-[2-[...)
Affinity DataIC50:  3nMAssay Description:For the Bir3 assay, 25.5 nanomolar BIR3 domain, corresponding to amino acids 260-352 of cIAP, was mixed with 41 nM of the peptide AVPIAQKSEK-(ε-...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetE3 ubiquitin-protein ligase XIAP [124-240](Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM412170((3R)-N-[2-[[(3S)-3-[(2,6- difluorophenyl)carbamoyl...)
Affinity DataIC50:  3nMAssay Description:For the Bir2 assay, 3.5 nanomolar of 6× Histidine-tagged BIR2 domain (6× Histidine disclosed as SEQ ID NO: 25), corresponding to amino acids 124-240 ...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetE3 ubiquitin-protein ligase XIAP [241-356](Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM412166((3S)-2-((S)-3,3-dimethyl-2- ((S)-2- (methylamino)p...)
Affinity DataIC50:  3nMAssay Description:For the Bir3 assay, 13.3 nanomolar BIR3 domain, corresponding to amino acids 241-356 of XIAP, was mixed with 25.2 nM of the peptide AVPIAQKSEK-(ε...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetBaculoviral IAP repeat-containing protein 2 [260-351](Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM412179(US10398702, Example 18 | tert-Butyl (2R,5S)-4-[2-[...)
Affinity DataIC50:  3nMAssay Description:For the Bir3 assay, 25.5 nanomolar BIR3 domain, corresponding to amino acids 260-352 of cIAP, was mixed with 41 nM of the peptide AVPIAQKSEK-(ε-...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetE3 ubiquitin-protein ligase XIAP [124-240](Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM412176(US10398702, Example 15 | tert-Butyl (2R,5S)-4-[2-[...)
Affinity DataIC50:  3.80nMAssay Description:For the Bir2 assay, 3.5 nanomolar of 6× Histidine-tagged BIR2 domain (6× Histidine disclosed as SEQ ID NO: 25), corresponding to amino acids 124-240 ...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetE3 ubiquitin-protein ligase XIAP [124-240](Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM412181((S)-N-(2-(((S)-3-((2,6- difluorophenyl)carbamoyl)-...)
Affinity DataIC50:  4nMAssay Description:For the Bir2 assay, 3.5 nanomolar of 6× Histidine-tagged BIR2 domain (6× Histidine disclosed as SEQ ID NO: 25), corresponding to amino acids 124-240 ...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetE3 ubiquitin-protein ligase XIAP [124-240](Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM412182(US10398702, Example 21 | tert-Butyl (2R,5S)-4-[2-[...)
Affinity DataIC50:  4nMAssay Description:For the Bir2 assay, 3.5 nanomolar of 6× Histidine-tagged BIR2 domain (6× Histidine disclosed as SEQ ID NO: 25), corresponding to amino acids 124-240 ...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetBaculoviral IAP repeat-containing protein 2 [260-351](Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM412167((3S)-2-((S)-3,3-dimethyl- 2-((S)-2- (methylamino)p...)
Affinity DataIC50:  4nMAssay Description:For the Bir3 assay, 25.5 nanomolar BIR3 domain, corresponding to amino acids 260-352 of cIAP, was mixed with 41 nM of the peptide AVPIAQKSEK-(ε-...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetBaculoviral IAP repeat-containing protein 2 [260-351](Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM412165(N-(4-(((S)-3-((2,6- difluorophenyl)carbamoyl)- 2-(...)
Affinity DataIC50:  4nMAssay Description:For the Bir3 assay, 25.5 nanomolar BIR3 domain, corresponding to amino acids 260-352 of cIAP, was mixed with 41 nM of the peptide AVPIAQKSEK-(ε-...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetE3 ubiquitin-protein ligase XIAP [241-356](Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM412169((3S)-N-[2-[[(3S)-3-[(2,6- difluorophenyl)carbamoyl...)
Affinity DataIC50:  4nMAssay Description:For the Bir3 assay, 13.3 nanomolar BIR3 domain, corresponding to amino acids 241-356 of XIAP, was mixed with 25.2 nM of the peptide AVPIAQKSEK-(ε...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetBaculoviral IAP repeat-containing protein 2 [260-351](Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM412166((3S)-2-((S)-3,3-dimethyl-2- ((S)-2- (methylamino)p...)
Affinity DataIC50:  4nMAssay Description:For the Bir3 assay, 25.5 nanomolar BIR3 domain, corresponding to amino acids 260-352 of cIAP, was mixed with 41 nM of the peptide AVPIAQKSEK-(ε-...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetE3 ubiquitin-protein ligase XIAP [241-356](Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM412181((S)-N-(2-(((S)-3-((2,6- difluorophenyl)carbamoyl)-...)
Affinity DataIC50:  5nMAssay Description:For the Bir3 assay, 13.3 nanomolar BIR3 domain, corresponding to amino acids 241-356 of XIAP, was mixed with 25.2 nM of the peptide AVPIAQKSEK-(ε...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetE3 ubiquitin-protein ligase XIAP [124-240](Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM412165(N-(4-(((S)-3-((2,6- difluorophenyl)carbamoyl)- 2-(...)
Affinity DataIC50:  5nMAssay Description:For the Bir2 assay, 3.5 nanomolar of 6× Histidine-tagged BIR2 domain (6× Histidine disclosed as SEQ ID NO: 25), corresponding to amino acids 124-240 ...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetE3 ubiquitin-protein ligase XIAP [124-240](Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM412179(US10398702, Example 18 | tert-Butyl (2R,5S)-4-[2-[...)
Affinity DataIC50:  6nMAssay Description:For the Bir2 assay, 3.5 nanomolar of 6× Histidine-tagged BIR2 domain (6× Histidine disclosed as SEQ ID NO: 25), corresponding to amino acids 124-240 ...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetE3 ubiquitin-protein ligase XIAP [124-240](Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM412178(US10398702, Example 17 | tert-Butyl N-[(1 S)-2-[[(...)
Affinity DataIC50:  6nMAssay Description:For the Bir2 assay, 3.5 nanomolar of 6× Histidine-tagged BIR2 domain (6× Histidine disclosed as SEQ ID NO: 25), corresponding to amino acids 124-240 ...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetE3 ubiquitin-protein ligase XIAP [241-356](Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM412182(US10398702, Example 21 | tert-Butyl (2R,5S)-4-[2-[...)
Affinity DataIC50:  6nMAssay Description:For the Bir3 assay, 13.3 nanomolar BIR3 domain, corresponding to amino acids 241-356 of XIAP, was mixed with 25.2 nM of the peptide AVPIAQKSEK-(ε...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetBaculoviral IAP repeat-containing protein 2 [260-351](Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM412163(N-(2-(((S)-3-((2,6- difluorophenyl)carbamoyl)- 2-(...)
Affinity DataIC50:  6nMAssay Description:For the Bir3 assay, 25.5 nanomolar BIR3 domain, corresponding to amino acids 260-352 of cIAP, was mixed with 41 nM of the peptide AVPIAQKSEK-(ε-...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetE3 ubiquitin-protein ligase XIAP [124-240](Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM412163(N-(2-(((S)-3-((2,6- difluorophenyl)carbamoyl)- 2-(...)
Affinity DataIC50:  6nMAssay Description:For the Bir2 assay, 3.5 nanomolar of 6× Histidine-tagged BIR2 domain (6× Histidine disclosed as SEQ ID NO: 25), corresponding to amino acids 124-240 ...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetBaculoviral IAP repeat-containing protein 2 [260-351](Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM412162(N-((S)-3-((2,6- difluorophenyl)carbamoyl)- 2-((S)-...)
Affinity DataIC50:  6nMAssay Description:For the Bir3 assay, 25.5 nanomolar BIR3 domain, corresponding to amino acids 260-352 of cIAP, was mixed with 41 nM of the peptide AVPIAQKSEK-(ε-...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetBaculoviral IAP repeat-containing protein 2 [260-351](Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM412172((3S)-2-[(2S)-3,3-dimethyl-2- [[(2S)-2- (methylamin...)
Affinity DataIC50:  7nMAssay Description:For the Bir3 assay, 25.5 nanomolar BIR3 domain, corresponding to amino acids 260-352 of cIAP, was mixed with 41 nM of the peptide AVPIAQKSEK-(ε-...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetE3 ubiquitin-protein ligase XIAP [241-356](Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM412178(US10398702, Example 17 | tert-Butyl N-[(1 S)-2-[[(...)
Affinity DataIC50:  7nMAssay Description:For the Bir3 assay, 13.3 nanomolar BIR3 domain, corresponding to amino acids 241-356 of XIAP, was mixed with 25.2 nM of the peptide AVPIAQKSEK-(ε...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetE3 ubiquitin-protein ligase XIAP [124-240](Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM412162(N-((S)-3-((2,6- difluorophenyl)carbamoyl)- 2-((S)-...)
Affinity DataIC50:  7nMAssay Description:For the Bir2 assay, 3.5 nanomolar of 6× Histidine-tagged BIR2 domain (6× Histidine disclosed as SEQ ID NO: 25), corresponding to amino acids 124-240 ...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetBaculoviral IAP repeat-containing protein 2 [260-351](Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM412175(N-(2-(4-fluoro-3-((S)-2-((S)- 2-((S)-2- (methylami...)
Affinity DataIC50:  7nMAssay Description:For the Bir3 assay, 25.5 nanomolar BIR3 domain, corresponding to amino acids 260-352 of cIAP, was mixed with 41 nM of the peptide AVPIAQKSEK-(ε-...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetE3 ubiquitin-protein ligase XIAP [241-356](Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM412167((3S)-2-((S)-3,3-dimethyl- 2-((S)-2- (methylamino)p...)
Affinity DataIC50:  8nMAssay Description:For the Bir3 assay, 13.3 nanomolar BIR3 domain, corresponding to amino acids 241-356 of XIAP, was mixed with 25.2 nM of the peptide AVPIAQKSEK-(ε...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetE3 ubiquitin-protein ligase XIAP [124-240](Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM412168(N1-((S)-3-((2,6- difluorophenyl)carbamoyl)-2- ((S)...)
Affinity DataIC50:  8nMAssay Description:For the Bir2 assay, 3.5 nanomolar of 6× Histidine-tagged BIR2 domain (6× Histidine disclosed as SEQ ID NO: 25), corresponding to amino acids 124-240 ...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetE3 ubiquitin-protein ligase XIAP [241-356](Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM412180(US10398702, Example 19 | tert-Butyl (2R,5S)-4-[2-[...)
Affinity DataIC50:  8nMAssay Description:For the Bir3 assay, 13.3 nanomolar BIR3 domain, corresponding to amino acids 241-356 of XIAP, was mixed with 25.2 nM of the peptide AVPIAQKSEK-(ε...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetE3 ubiquitin-protein ligase XIAP [241-356](Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM412183(US10398702, Example 22 | tert-Butyl (2R,5S)-4-[2-[...)
Affinity DataIC50:  9nMAssay Description:For the Bir3 assay, 13.3 nanomolar BIR3 domain, corresponding to amino acids 241-356 of XIAP, was mixed with 25.2 nM of the peptide AVPIAQKSEK-(ε...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetE3 ubiquitin-protein ligase XIAP [241-356](Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM412176(US10398702, Example 15 | tert-Butyl (2R,5S)-4-[2-[...)
Affinity DataIC50:  9nMAssay Description:For the Bir3 assay, 13.3 nanomolar BIR3 domain, corresponding to amino acids 241-356 of XIAP, was mixed with 25.2 nM of the peptide AVPIAQKSEK-(ε...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetBaculoviral IAP repeat-containing protein 2 [260-351](Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM412168(N1-((S)-3-((2,6- difluorophenyl)carbamoyl)-2- ((S)...)
Affinity DataIC50:  10nMAssay Description:For the Bir3 assay, 25.5 nanomolar BIR3 domain, corresponding to amino acids 260-352 of cIAP, was mixed with 41 nM of the peptide AVPIAQKSEK-(ε-...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetBaculoviral IAP repeat-containing protein 2 [260-351](Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM412177(N-(4-(4-fluoro-3-((S)-2-((S)- 2-((S)-2- (methylami...)
Affinity DataIC50:  10nMAssay Description:For the Bir3 assay, 25.5 nanomolar BIR3 domain, corresponding to amino acids 260-352 of cIAP, was mixed with 41 nM of the peptide AVPIAQKSEK-(ε-...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetBaculoviral IAP repeat-containing protein 2 [260-351](Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM412164(US10398702, Example 3 | tert-Butyl (2R,5S)-4-[2-[3...)
Affinity DataIC50:  10nMAssay Description:For the Bir3 assay, 25.5 nanomolar BIR3 domain, corresponding to amino acids 260-352 of cIAP, was mixed with 41 nM of the peptide AVPIAQKSEK-(ε-...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetBaculoviral IAP repeat-containing protein 2 [260-351](Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM412174(US10398702, Example 13 | tert-Butyl (2R,5S)-4-[2-[...)
Affinity DataIC50:  10nMAssay Description:For the Bir3 assay, 25.5 nanomolar BIR3 domain, corresponding to amino acids 260-352 of cIAP, was mixed with 41 nM of the peptide AVPIAQKSEK-(ε-...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetE3 ubiquitin-protein ligase XIAP [124-240](Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM412180(US10398702, Example 19 | tert-Butyl (2R,5S)-4-[2-[...)
Affinity DataIC50:  11nMAssay Description:For the Bir2 assay, 3.5 nanomolar of 6× Histidine-tagged BIR2 domain (6× Histidine disclosed as SEQ ID NO: 25), corresponding to amino acids 124-240 ...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetE3 ubiquitin-protein ligase XIAP [241-356](Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM412162(N-((S)-3-((2,6- difluorophenyl)carbamoyl)- 2-((S)-...)
Affinity DataIC50:  11nMAssay Description:For the Bir3 assay, 13.3 nanomolar BIR3 domain, corresponding to amino acids 241-356 of XIAP, was mixed with 25.2 nM of the peptide AVPIAQKSEK-(ε...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetE3 ubiquitin-protein ligase XIAP [241-356](Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM412179(US10398702, Example 18 | tert-Butyl (2R,5S)-4-[2-[...)
Affinity DataIC50:  11nMAssay Description:For the Bir3 assay, 13.3 nanomolar BIR3 domain, corresponding to amino acids 241-356 of XIAP, was mixed with 25.2 nM of the peptide AVPIAQKSEK-(ε...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetE3 ubiquitin-protein ligase XIAP [241-356](Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM412163(N-(2-(((S)-3-((2,6- difluorophenyl)carbamoyl)- 2-(...)
Affinity DataIC50:  13nMAssay Description:For the Bir3 assay, 13.3 nanomolar BIR3 domain, corresponding to amino acids 241-356 of XIAP, was mixed with 25.2 nM of the peptide AVPIAQKSEK-(ε...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetE3 ubiquitin-protein ligase XIAP [241-356](Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM412165(N-(4-(((S)-3-((2,6- difluorophenyl)carbamoyl)- 2-(...)
Affinity DataIC50:  13nMAssay Description:For the Bir3 assay, 13.3 nanomolar BIR3 domain, corresponding to amino acids 241-356 of XIAP, was mixed with 25.2 nM of the peptide AVPIAQKSEK-(ε...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetE3 ubiquitin-protein ligase XIAP [241-356](Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM412173((R)-N-((S)-3-((2,6- difluorophenyl)carbamoyl)- 2-(...)
Affinity DataIC50:  17nMAssay Description:For the Bir3 assay, 13.3 nanomolar BIR3 domain, corresponding to amino acids 241-356 of XIAP, was mixed with 25.2 nM of the peptide AVPIAQKSEK-(ε...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
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