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Patent code US10398703

Compile Data Set for Download or QSAR
Found 23 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM412200
PNG
(US10398703, Compound 43a)
Show SMILES COc1cc2c(Oc3ccc(NC(=O)Nc4cc(C)ccc4F)c(Cl)c3)ccnc2cc1OCCCC(=O)N1CCC2(COC2)CC1
Show InChI InChI=1S/C35H36ClFN4O6/c1-22-5-7-26(37)29(16-22)40-34(43)39-27-8-6-23(17-25(27)36)47-30-9-12-38-28-19-32(31(44-2)18-24(28)30)46-15-3-4-33(42)41-13-10-35(11-14-41)20-45-21-35/h5-9,12,16-19H,3-4,10-11,13-15,20-21H2,1-2H3,(H2,39,40,43)
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n/an/an/a 3.10E+4n/an/an/an/an/a



Kala Pharmaceuticals, Inc.

US Patent


Assay Description
A competition binding assay (DISCOVERX KINOMESCAN™) was used to measure the ability of a compound to compete for binding of an immobilized adenosine ...


US Patent US10398703 (2019)


BindingDB Entry DOI: 10.7270/Q2QR50HB
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM412210
PNG
(US10398703, Compound 57)
Show SMILES COc1cc2ncnc(Oc3ccc(NC(=O)Nc4cccc(CN(C)CCO)c4)c(Cl)c3)c2cc1OC
Show InChI InChI=1S/C27H28ClN5O5/c1-33(9-10-34)15-17-5-4-6-18(11-17)31-27(35)32-22-8-7-19(12-21(22)28)38-26-20-13-24(36-2)25(37-3)14-23(20)29-16-30-26/h4-8,11-14,16,34H,9-10,15H2,1-3H3,(H2,31,32,35)
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n/an/an/a 1.30E+3n/an/an/an/an/a



Kala Pharmaceuticals, Inc.

US Patent


Assay Description
A competition binding assay (DISCOVERX KINOMESCAN™) was used to measure the ability of a compound to compete for binding of an immobilized adenosine ...


US Patent US10398703 (2019)


BindingDB Entry DOI: 10.7270/Q2QR50HB
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM412206
PNG
(US10398703, Compound 53)
Show SMILES COc1cc2ncnc(Oc3ccc(NC(=O)Nc4ccc(CN5CCOCC5)cc4)c(Cl)c3)c2cc1OC
Show InChI InChI=1S/C28H28ClN5O5/c1-36-25-14-21-24(15-26(25)37-2)30-17-31-27(21)39-20-7-8-23(22(29)13-20)33-28(35)32-19-5-3-18(4-6-19)16-34-9-11-38-12-10-34/h3-8,13-15,17H,9-12,16H2,1-2H3,(H2,32,33,35)
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n/an/an/a 3.30E+3n/an/an/an/an/a



Kala Pharmaceuticals, Inc.

US Patent


Assay Description
A competition binding assay (DISCOVERX KINOMESCAN™) was used to measure the ability of a compound to compete for binding of an immobilized adenosine ...


US Patent US10398703 (2019)


BindingDB Entry DOI: 10.7270/Q2QR50HB
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM412197
PNG
(US10398703, Compound 30)
Show SMILES COc1cc2c(Oc3ccc(NC(=O)Nc4cc(C)on4)c(Cl)c3)ccnc2cc1OCCCN1CCC2(COC2)CC1
Show InChI InChI=1S/C31H34ClN5O6/c1-20-14-29(36-43-20)35-30(38)34-24-5-4-21(15-23(24)32)42-26-6-9-33-25-17-28(27(39-2)16-22(25)26)41-13-3-10-37-11-7-31(8-12-37)18-40-19-31/h4-6,9,14-17H,3,7-8,10-13,18-19H2,1-2H3,(H2,34,35,36,38)
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n/an/an/a 690n/an/an/an/an/a



Kala Pharmaceuticals, Inc.

US Patent


Assay Description
A competition binding assay (DISCOVERX KINOMESCAN™) was used to measure the ability of a compound to compete for binding of an immobilized adenosine ...


US Patent US10398703 (2019)


BindingDB Entry DOI: 10.7270/Q2QR50HB
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM412203
PNG
(US10398703, Compound 49)
Show SMILES COc1cc2c(Oc3ccc(NC(=O)Nc4cc(C)on4)c(Cl)c3)ncnc2cc1OCCCOC1COC1
Show InChI InChI=1S/C26H26ClN5O7/c1-15-8-24(32-39-15)31-26(33)30-20-5-4-16(9-19(20)27)38-25-18-10-22(34-2)23(11-21(18)28-14-29-25)37-7-3-6-36-17-12-35-13-17/h4-5,8-11,14,17H,3,6-7,12-13H2,1-2H3,(H2,30,31,32,33)
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n/an/an/a 980n/an/an/an/an/a



Kala Pharmaceuticals, Inc.

US Patent


Assay Description
A competition binding assay (DISCOVERX KINOMESCAN™) was used to measure the ability of a compound to compete for binding of an immobilized adenosine ...


US Patent US10398703 (2019)


BindingDB Entry DOI: 10.7270/Q2QR50HB
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM412191
PNG
(US10398703, Compound 14)
Show SMILES COc1cc2c(Oc3ccc(NC(=O)c4cc(C)nn4C)c(Cl)c3)ncnc2cc1OCCCN1CCC2(COC2)CC1
Show InChI InChI=1S/C31H35ClN6O5/c1-20-13-26(37(2)36-20)29(39)35-24-6-5-21(14-23(24)32)43-30-22-15-27(40-3)28(16-25(22)33-19-34-30)42-12-4-9-38-10-7-31(8-11-38)17-41-18-31/h5-6,13-16,19H,4,7-12,17-18H2,1-3H3,(H,35,39)
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n/an/an/a 3.70E+4n/an/an/an/an/a



Kala Pharmaceuticals, Inc.

US Patent


Assay Description
A competition binding assay (DISCOVERX KINOMESCAN™) was used to measure the ability of a compound to compete for binding of an immobilized adenosine ...


US Patent US10398703 (2019)


BindingDB Entry DOI: 10.7270/Q2QR50HB
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM412195
PNG
(US10398703, Compound 21)
Show SMILES COc1cc2c(Oc3ccc(NC(=O)c4cc(C)nn4C)c(C)c3)ncnc2cc1OCCCN1CCC2(COC2)CC1
Show InChI InChI=1S/C32H38N6O5/c1-21-14-23(6-7-25(21)35-30(39)27-15-22(2)36-37(27)3)43-31-24-16-28(40-4)29(17-26(24)33-20-34-31)42-13-5-10-38-11-8-32(9-12-38)18-41-19-32/h6-7,14-17,20H,5,8-13,18-19H2,1-4H3,(H,35,39)
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n/an/an/a 5.80E+4n/an/an/an/an/a



Kala Pharmaceuticals, Inc.

US Patent


Assay Description
A competition binding assay (DISCOVERX KINOMESCAN™) was used to measure the ability of a compound to compete for binding of an immobilized adenosine ...


US Patent US10398703 (2019)


BindingDB Entry DOI: 10.7270/Q2QR50HB
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM412198
PNG
(US10398703, Compound 35)
Show SMILES COc1cc2c(Oc3ccc(NC(=O)Nc4cc(C)on4)c(Cl)c3)ncnc2cc1OCCCC(=O)N1CCC2(COC2)CC1
Show InChI InChI=1S/C31H33ClN6O7/c1-19-12-27(37-45-19)36-30(40)35-23-6-5-20(13-22(23)32)44-29-21-14-25(41-2)26(15-24(21)33-18-34-29)43-11-3-4-28(39)38-9-7-31(8-10-38)16-42-17-31/h5-6,12-15,18H,3-4,7-11,16-17H2,1-2H3,(H2,35,36,37,40)
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n/an/an/a 1.30E+3n/an/an/an/an/a



Kala Pharmaceuticals, Inc.

US Patent


Assay Description
A competition binding assay (DISCOVERX KINOMESCAN™) was used to measure the ability of a compound to compete for binding of an immobilized adenosine ...


US Patent US10398703 (2019)


BindingDB Entry DOI: 10.7270/Q2QR50HB
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM412205
PNG
(US10398703, Compound 52)
Show SMILES COc1cc2ncnc(Oc3ccc(NC(=O)Nc4ccccc4CN4CCOCC4)c(Cl)c3)c2cc1OC
Show InChI InChI=1S/C28H28ClN5O5/c1-36-25-14-20-24(15-26(25)37-2)30-17-31-27(20)39-19-7-8-23(21(29)13-19)33-28(35)32-22-6-4-3-5-18(22)16-34-9-11-38-12-10-34/h3-8,13-15,17H,9-12,16H2,1-2H3,(H2,32,33,35)
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n/an/an/a 1.20E+5n/an/an/an/an/a



Kala Pharmaceuticals, Inc.

US Patent


Assay Description
A competition binding assay (DISCOVERX KINOMESCAN™) was used to measure the ability of a compound to compete for binding of an immobilized adenosine ...


US Patent US10398703 (2019)


BindingDB Entry DOI: 10.7270/Q2QR50HB
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM412193
PNG
(US10398703, Compound 16)
Show SMILES COc1cc2c(Oc3ccc(NC(=O)Nc4ccsc4)c(Cl)c3)ncnc2cc1OCCCN1CCC2(COC2)CC1
Show InChI InChI=1S/C30H32ClN5O5S/c1-38-26-14-22-25(15-27(26)40-11-2-8-36-9-6-30(7-10-36)17-39-18-30)32-19-33-28(22)41-21-3-4-24(23(31)13-21)35-29(37)34-20-5-12-42-16-20/h3-5,12-16,19H,2,6-11,17-18H2,1H3,(H2,34,35,37)
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n/an/an/a 520n/an/an/an/an/a



Kala Pharmaceuticals, Inc.

US Patent


Assay Description
A competition binding assay (DISCOVERX KINOMESCAN™) was used to measure the ability of a compound to compete for binding of an immobilized adenosine ...


US Patent US10398703 (2019)


BindingDB Entry DOI: 10.7270/Q2QR50HB
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM412209
PNG
(US10398703, Compound 56)
Show SMILES COc1cc2ncnc(Oc3ccc(NC(=O)Nc4ccc(OCCCN(C)C)cc4)c(Cl)c3)c2cc1OC
Show InChI InChI=1S/C28H30ClN5O5/c1-34(2)12-5-13-38-19-8-6-18(7-9-19)32-28(35)33-23-11-10-20(14-22(23)29)39-27-21-15-25(36-3)26(37-4)16-24(21)30-17-31-27/h6-11,14-17H,5,12-13H2,1-4H3,(H2,32,33,35)
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n/an/an/a 2.40E+3n/an/an/an/an/a



Kala Pharmaceuticals, Inc.

US Patent


Assay Description
A competition binding assay (DISCOVERX KINOMESCAN™) was used to measure the ability of a compound to compete for binding of an immobilized adenosine ...


US Patent US10398703 (2019)


BindingDB Entry DOI: 10.7270/Q2QR50HB
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM412196
PNG
(US10398703, Compound 25)
Show SMILES COc1cc2c(Oc3ccc(NC(=O)Nc4cc(C)ccc4F)c(Cl)c3)ccnc2cc1OCCCN1CCC2(COC2)CC1
Show InChI InChI=1S/C34H36ClFN4O5/c1-22-4-6-26(36)29(16-22)39-33(41)38-27-7-5-23(17-25(27)35)45-30-8-11-37-28-19-32(31(42-2)18-24(28)30)44-15-3-12-40-13-9-34(10-14-40)20-43-21-34/h4-8,11,16-19H,3,9-10,12-15,20-21H2,1-2H3,(H2,38,39,41)
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n/an/an/a 4.80E+3n/an/an/an/an/a



Kala Pharmaceuticals, Inc.

US Patent


Assay Description
A competition binding assay (DISCOVERX KINOMESCAN™) was used to measure the ability of a compound to compete for binding of an immobilized adenosine ...


US Patent US10398703 (2019)


BindingDB Entry DOI: 10.7270/Q2QR50HB
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM412199
PNG
(US10398703, Compound 38)
Show SMILES COc1cc2c(Oc3ccc(NC(=O)Nc4cc(C)ccc4F)c(Cl)c3)ncnc2cc1OCCCC(=O)N1CCC2(COC2)CC1
Show InChI InChI=1S/C34H35ClFN5O6/c1-21-5-7-25(36)28(14-21)40-33(43)39-26-8-6-22(15-24(26)35)47-32-23-16-29(44-2)30(17-27(23)37-20-38-32)46-13-3-4-31(42)41-11-9-34(10-12-41)18-45-19-34/h5-8,14-17,20H,3-4,9-13,18-19H2,1-2H3,(H2,39,40,43)
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n/an/an/a 1.00E+4n/an/an/an/an/a



Kala Pharmaceuticals, Inc.

US Patent


Assay Description
A competition binding assay (DISCOVERX KINOMESCAN™) was used to measure the ability of a compound to compete for binding of an immobilized adenosine ...


US Patent US10398703 (2019)


BindingDB Entry DOI: 10.7270/Q2QR50HB
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM412201
PNG
(US10398703, Compound 43b)
Show SMILES COc1cc2c(Oc3ccc(NC(=O)Nc4cc(C)ccc4F)cc3)ccnc2cc1OCCCC(=O)N1CCC2(COC2)CC1
Show InChI InChI=1S/C35H37FN4O6/c1-23-5-10-27(36)29(18-23)39-34(42)38-24-6-8-25(9-7-24)46-30-11-14-37-28-20-32(31(43-2)19-26(28)30)45-17-3-4-33(41)40-15-12-35(13-16-40)21-44-22-35/h5-11,14,18-20H,3-4,12-13,15-17,21-22H2,1-2H3,(H2,38,39,42)
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n/an/an/a 8.70E+3n/an/an/an/an/a



Kala Pharmaceuticals, Inc.

US Patent


Assay Description
A competition binding assay (DISCOVERX KINOMESCAN™) was used to measure the ability of a compound to compete for binding of an immobilized adenosine ...


US Patent US10398703 (2019)


BindingDB Entry DOI: 10.7270/Q2QR50HB
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM412192
PNG
(US10398703, Compound 15)
Show SMILES COc1cc2c(Oc3ccc(NC(=O)Nc4ccc(Cl)c(c4)C(F)(F)F)c(Cl)c3)ncnc2cc1OCCCN1CCC2(COC2)CC1
Show InChI InChI=1S/C33H32Cl2F3N5O5/c1-45-28-15-22-27(16-29(28)47-12-2-9-43-10-7-32(8-11-43)17-46-18-32)39-19-40-30(22)48-21-4-6-26(25(35)14-21)42-31(44)41-20-3-5-24(34)23(13-20)33(36,37)38/h3-6,13-16,19H,2,7-12,17-18H2,1H3,(H2,41,42,44)
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n/an/an/a 2.00E+4n/an/an/an/an/a



Kala Pharmaceuticals, Inc.

US Patent


Assay Description
A competition binding assay (DISCOVERX KINOMESCAN™) was used to measure the ability of a compound to compete for binding of an immobilized adenosine ...


US Patent US10398703 (2019)


BindingDB Entry DOI: 10.7270/Q2QR50HB
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM412208
PNG
(US10398703, Compound 55)
Show SMILES COc1cc2ncnc(Oc3ccc(NC(=O)Nc4ccc(CN5CCN(C)CC5)cc4)c(Cl)c3)c2cc1OC
Show InChI InChI=1S/C29H31ClN6O4/c1-35-10-12-36(13-11-35)17-19-4-6-20(7-5-19)33-29(37)34-24-9-8-21(14-23(24)30)40-28-22-15-26(38-2)27(39-3)16-25(22)31-18-32-28/h4-9,14-16,18H,10-13,17H2,1-3H3,(H2,33,34,37)
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n/an/an/a 1.70E+3n/an/an/an/an/a



Kala Pharmaceuticals, Inc.

US Patent


Assay Description
A competition binding assay (DISCOVERX KINOMESCAN™) was used to measure the ability of a compound to compete for binding of an immobilized adenosine ...


US Patent US10398703 (2019)


BindingDB Entry DOI: 10.7270/Q2QR50HB
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM412194
PNG
(US10398703, Compound 17)
Show SMILES CCCNC(=O)Nc1ccc(Oc2ncnc3cc(OCCCN4CCC5(COC5)CC4)c(OC)cc23)cc1Cl
Show InChI InChI=1S/C29H36ClN5O5/c1-3-9-31-28(36)34-23-6-5-20(14-22(23)30)40-27-21-15-25(37-2)26(16-24(21)32-19-33-27)39-13-4-10-35-11-7-29(8-12-35)17-38-18-29/h5-6,14-16,19H,3-4,7-13,17-18H2,1-2H3,(H2,31,34,36)
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n/an/an/a 1.00E+3n/an/an/an/an/a



Kala Pharmaceuticals, Inc.

US Patent


Assay Description
A competition binding assay (DISCOVERX KINOMESCAN™) was used to measure the ability of a compound to compete for binding of an immobilized adenosine ...


US Patent US10398703 (2019)


BindingDB Entry DOI: 10.7270/Q2QR50HB
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM412189
PNG
(US10398703, Compound 9)
Show SMILES COc1cc2c(Oc3ccc(NC(=O)Nc4cc(C)on4)c(Cl)c3)ncnc2cc1OCCCN1CCC2(COC2)CC1
Show InChI InChI=1S/C30H33ClN6O6/c1-19-12-27(36-43-19)35-29(38)34-23-5-4-20(13-22(23)31)42-28-21-14-25(39-2)26(15-24(21)32-18-33-28)41-11-3-8-37-9-6-30(7-10-37)16-40-17-30/h4-5,12-15,18H,3,6-11,16-17H2,1-2H3,(H2,34,35,36,38)
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n/an/an/a 490n/an/an/an/an/a



Kala Pharmaceuticals, Inc.

US Patent


Assay Description
A competition binding assay (DISCOVERX KINOMESCAN™) was used to measure the ability of a compound to compete for binding of an immobilized adenosine ...


US Patent US10398703 (2019)


BindingDB Entry DOI: 10.7270/Q2QR50HB
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM412202
PNG
(US10398703, Compound 48)
Show SMILES COc1cc2c(Oc3ccc(NC(=O)Nc4cc(C)ccc4F)c(Cl)c3)ncnc2cc1OCCCOC1COC1
Show InChI InChI=1S/C29H28ClFN4O6/c1-17-4-6-22(31)25(10-17)35-29(36)34-23-7-5-18(11-21(23)30)41-28-20-12-26(37-2)27(13-24(20)32-16-33-28)40-9-3-8-39-19-14-38-15-19/h4-7,10-13,16,19H,3,8-9,14-15H2,1-2H3,(H2,34,35,36)
PDB
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n/an/an/a 1.40E+4n/an/an/an/an/a



Kala Pharmaceuticals, Inc.

US Patent


Assay Description
A competition binding assay (DISCOVERX KINOMESCAN™) was used to measure the ability of a compound to compete for binding of an immobilized adenosine ...


US Patent US10398703 (2019)


BindingDB Entry DOI: 10.7270/Q2QR50HB
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM412204
PNG
(US10398703, Compound 50)
Show SMILES COc1cc2c(Oc3ccc(NC(=O)Nc4cc(C)ccc4F)c(Cl)c3)ccnc2cc1OCCCOC1COC1
Show InChI InChI=1S/C30H29ClFN3O6/c1-18-4-6-23(32)26(12-18)35-30(36)34-24-7-5-19(13-22(24)31)41-27-8-9-33-25-15-29(28(37-2)14-21(25)27)40-11-3-10-39-20-16-38-17-20/h4-9,12-15,20H,3,10-11,16-17H2,1-2H3,(H2,34,35,36)
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n/an/an/a 2.50E+4n/an/an/an/an/a



Kala Pharmaceuticals, Inc.

US Patent


Assay Description
A competition binding assay (DISCOVERX KINOMESCAN™) was used to measure the ability of a compound to compete for binding of an immobilized adenosine ...


US Patent US10398703 (2019)


BindingDB Entry DOI: 10.7270/Q2QR50HB
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM412190
PNG
(US10398703, Compound 12)
Show SMILES COc1cc2c(Oc3ccc(NC(=O)Nc4cc(C)ccc4F)c(Cl)c3)ncnc2cc1OCCCN1CCC2(COC2)CC1
Show InChI InChI=1S/C33H35ClFN5O5/c1-21-4-6-25(35)28(14-21)39-32(41)38-26-7-5-22(15-24(26)34)45-31-23-16-29(42-2)30(17-27(23)36-20-37-31)44-13-3-10-40-11-8-33(9-12-40)18-43-19-33/h4-7,14-17,20H,3,8-13,18-19H2,1-2H3,(H2,38,39,41)
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n/an/an/a 3.20E+3n/an/an/an/an/a



Kala Pharmaceuticals, Inc.

US Patent


Assay Description
A competition binding assay (DISCOVERX KINOMESCAN™) was used to measure the ability of a compound to compete for binding of an immobilized adenosine ...


US Patent US10398703 (2019)


BindingDB Entry DOI: 10.7270/Q2QR50HB
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM412207
PNG
(US10398703, Compound 54)
Show SMILES COc1cc2ncnc(Oc3ccc(NC(=O)Nc4ccccc4CN4CCN(C)CC4)c(Cl)c3)c2cc1OC
Show InChI InChI=1S/C29H31ClN6O4/c1-35-10-12-36(13-11-35)17-19-6-4-5-7-23(19)33-29(37)34-24-9-8-20(14-22(24)30)40-28-21-15-26(38-2)27(39-3)16-25(21)31-18-32-28/h4-9,14-16,18H,10-13,17H2,1-3H3,(H2,33,34,37)
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n/an/an/a 2.70E+4n/an/an/an/an/a



Kala Pharmaceuticals, Inc.

US Patent


Assay Description
A competition binding assay (DISCOVERX KINOMESCAN™) was used to measure the ability of a compound to compete for binding of an immobilized adenosine ...


US Patent US10398703 (2019)


BindingDB Entry DOI: 10.7270/Q2QR50HB
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM412211
PNG
(US10398703, Compound 58)
Show SMILES CCN1CCN(CC1)c1ccc(Cl)cc1NC(=O)Nc1ccc(Oc2ncnc3cc(OC)c(OC)cc23)cc1Cl
Show InChI InChI=1S/C29H30Cl2N6O4/c1-4-36-9-11-37(12-10-36)25-8-5-18(30)13-24(25)35-29(38)34-22-7-6-19(14-21(22)31)41-28-20-15-26(39-2)27(40-3)16-23(20)32-17-33-28/h5-8,13-17H,4,9-12H2,1-3H3,(H2,34,35,38)
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n/an/an/a 1.00E+4n/an/an/an/an/a



Kala Pharmaceuticals, Inc.

US Patent


Assay Description
A competition binding assay (DISCOVERX KINOMESCAN™) was used to measure the ability of a compound to compete for binding of an immobilized adenosine ...


US Patent US10398703 (2019)


BindingDB Entry DOI: 10.7270/Q2QR50HB
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%