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Patent code US10398706

Compile Data Set for Download or QSAR
Found 9 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
RNA-directed RNA polymerase L


(Respiratory syncytial virus type A)
BDBM412217
PNG
(US10398706, Example 6 | US10398706, Example 7)
Show SMILES Cc1cc(C(=O)c2ccccc2)c(N)s1
Show InChI InChI=1S/C12H11NOS/c1-8-7-10(12(13)15-8)11(14)9-5-3-2-4-6-9/h2-7H,13H2,1H3
PDB
MMDB

KEGG

UniProtKB/TrEMBL

DrugBank
GoogleScholar
UniChem
US Patent
n/an/an/an/a<400n/an/an/an/a



Enanta Pharmaceuticals, Inc.

US Patent


Assay Description
Following extensive parameter testing, the final assay is run as follows: HEp-2 cells are seeded into the inner 60 wells of a 96-well plate at 8,000 ...


US Patent US10398706 (2019)


BindingDB Entry DOI: 10.7270/Q2M047VT
More data for this
Ligand-Target Pair
RNA-directed RNA polymerase L


(Respiratory syncytial virus type A)
BDBM412213
PNG
(US10398706, Example 2)
Show SMILES Fc1ccc(cc1)-c1nnc(NC2N=C(c3ccccc3)c3cccnc3NC2=O)o1
Show InChI InChI=1S/C22H15FN6O2/c23-15-10-8-14(9-11-15)21-28-29-22(31-21)27-19-20(30)26-18-16(7-4-12-24-18)17(25-19)13-5-2-1-3-6-13/h1-12,19H,(H,27,29)(H,24,26,30)
PDB
MMDB

KEGG

UniProtKB/TrEMBL

DrugBank
GoogleScholar
UniChem
US Patent
n/an/an/an/a>800n/an/an/an/a



Enanta Pharmaceuticals, Inc.

US Patent


Assay Description
Following extensive parameter testing, the final assay is run as follows: HEp-2 cells are seeded into the inner 60 wells of a 96-well plate at 8,000 ...


US Patent US10398706 (2019)


BindingDB Entry DOI: 10.7270/Q2M047VT
More data for this
Ligand-Target Pair
RNA-directed RNA polymerase L


(Respiratory syncytial virus type A)
BDBM412217
PNG
(US10398706, Example 6 | US10398706, Example 7)
Show SMILES Cc1cc(C(=O)c2ccccc2)c(N)s1
Show InChI InChI=1S/C12H11NOS/c1-8-7-10(12(13)15-8)11(14)9-5-3-2-4-6-9/h2-7H,13H2,1H3
PDB
MMDB

KEGG

UniProtKB/TrEMBL

DrugBank
GoogleScholar
UniChem
US Patent
n/an/an/an/a>800n/an/an/an/a



Enanta Pharmaceuticals, Inc.

US Patent


Assay Description
Following extensive parameter testing, the final assay is run as follows: HEp-2 cells are seeded into the inner 60 wells of a 96-well plate at 8,000 ...


US Patent US10398706 (2019)


BindingDB Entry DOI: 10.7270/Q2M047VT
More data for this
Ligand-Target Pair
RNA-directed RNA polymerase L


(Respiratory syncytial virus type A)
BDBM412212
PNG
(Step h | US10398706, Example 1)
Show SMILES O=C1Nc2cccnc2C(=NC1Nc1nnc(o1)-c1ccccc1)c1ccccc1
Show InChI InChI=1S/C22H16N6O2/c29-20-19(26-22-28-27-21(30-22)15-10-5-2-6-11-15)25-17(14-8-3-1-4-9-14)18-16(24-20)12-7-13-23-18/h1-13,19H,(H,24,29)(H,26,28)
PDB
MMDB

KEGG

UniProtKB/TrEMBL

DrugBank
GoogleScholar
UniChem
US Patent
n/an/an/an/a>800n/an/an/an/a



Enanta Pharmaceuticals, Inc.

US Patent


Assay Description
Following extensive parameter testing, the final assay is run as follows: HEp-2 cells are seeded into the inner 60 wells of a 96-well plate at 8,000 ...


US Patent US10398706 (2019)


BindingDB Entry DOI: 10.7270/Q2M047VT
More data for this
Ligand-Target Pair
RNA-directed RNA polymerase L


(Respiratory syncytial virus type A)
BDBM412219
PNG
(US10398706, Example 8 | US10398706, Example 9)
Show SMILES Cc1sc2NC(=O)C(Nc3nnc(o3)-c3ncc(cc3N3CCOCC3)C(F)(F)F)N=C(c2c1C)c1ccccc1
Show InChI InChI=1S/C27H24F3N7O3S/c1-14-15(2)41-25-19(14)20(16-6-4-3-5-7-16)32-22(23(38)34-25)33-26-36-35-24(40-26)21-18(37-8-10-39-11-9-37)12-17(13-31-21)27(28,29)30/h3-7,12-13,22H,8-11H2,1-2H3,(H,33,36)(H,34,38)
PDB
MMDB

KEGG

UniProtKB/TrEMBL

DrugBank
GoogleScholar
UniChem
US Patent
n/an/an/an/a>800n/an/an/an/a



Enanta Pharmaceuticals, Inc.

US Patent


Assay Description
Following extensive parameter testing, the final assay is run as follows: HEp-2 cells are seeded into the inner 60 wells of a 96-well plate at 8,000 ...


US Patent US10398706 (2019)


BindingDB Entry DOI: 10.7270/Q2M047VT
More data for this
Ligand-Target Pair
RNA-directed RNA polymerase L


(Respiratory syncytial virus type A)
BDBM412214
PNG
(US10398706, Example 3)
Show SMILES Fc1ccc(cc1)-c1nnc(NC2N=C(c3ccccc3)c3ccncc3NC2=O)o1
Show InChI InChI=1S/C22H15FN6O2/c23-15-8-6-14(7-9-15)21-28-29-22(31-21)27-19-20(30)25-17-12-24-11-10-16(17)18(26-19)13-4-2-1-3-5-13/h1-12,19H,(H,25,30)(H,27,29)
PDB
MMDB

KEGG

UniProtKB/TrEMBL

DrugBank
GoogleScholar
UniChem
US Patent
n/an/an/an/a>800n/an/an/an/a



Enanta Pharmaceuticals, Inc.

US Patent


Assay Description
Following extensive parameter testing, the final assay is run as follows: HEp-2 cells are seeded into the inner 60 wells of a 96-well plate at 8,000 ...


US Patent US10398706 (2019)


BindingDB Entry DOI: 10.7270/Q2M047VT
More data for this
Ligand-Target Pair
RNA-directed RNA polymerase L


(Respiratory syncytial virus type A)
BDBM412215
PNG
(Step e | US10398706, Example 4)
Show SMILES NC1N=C(c2sccc2NC1=O)c1ccccc1
Show InChI InChI=1S/C13H11N3OS/c14-12-13(17)15-9-6-7-18-11(9)10(16-12)8-4-2-1-3-5-8/h1-7,12H,14H2,(H,15,17)
PDB
MMDB

KEGG

UniProtKB/TrEMBL

DrugBank
GoogleScholar
UniChem
US Patent
n/an/an/an/a 600n/an/an/an/a



Enanta Pharmaceuticals, Inc.

US Patent


Assay Description
Following extensive parameter testing, the final assay is run as follows: HEp-2 cells are seeded into the inner 60 wells of a 96-well plate at 8,000 ...


US Patent US10398706 (2019)


BindingDB Entry DOI: 10.7270/Q2M047VT
More data for this
Ligand-Target Pair
RNA-directed RNA polymerase L


(Respiratory syncytial virus type A)
BDBM412219
PNG
(US10398706, Example 8 | US10398706, Example 9)
Show SMILES Cc1sc2NC(=O)C(Nc3nnc(o3)-c3ncc(cc3N3CCOCC3)C(F)(F)F)N=C(c2c1C)c1ccccc1
Show InChI InChI=1S/C27H24F3N7O3S/c1-14-15(2)41-25-19(14)20(16-6-4-3-5-7-16)32-22(23(38)34-25)33-26-36-35-24(40-26)21-18(37-8-10-39-11-9-37)12-17(13-31-21)27(28,29)30/h3-7,12-13,22H,8-11H2,1-2H3,(H,33,36)(H,34,38)
PDB
MMDB

KEGG

UniProtKB/TrEMBL

DrugBank
GoogleScholar
UniChem
US Patent
n/an/an/an/a 600n/an/an/an/a



Enanta Pharmaceuticals, Inc.

US Patent


Assay Description
Following extensive parameter testing, the final assay is run as follows: HEp-2 cells are seeded into the inner 60 wells of a 96-well plate at 8,000 ...


US Patent US10398706 (2019)


BindingDB Entry DOI: 10.7270/Q2M047VT
More data for this
Ligand-Target Pair
RNA-directed RNA polymerase L


(Respiratory syncytial virus type A)
BDBM412216
PNG
(Step c | US10398706, Example 5)
Show SMILES O=C(NC1N=C(c2ccsc2NC1=O)c1ccccc1)OCc1ccccc1
Show InChI InChI=1S/C21H17N3O3S/c25-19-18(23-21(26)27-13-14-7-3-1-4-8-14)22-17(15-9-5-2-6-10-15)16-11-12-28-20(16)24-19/h1-12,18H,13H2,(H,23,26)(H,24,25)
PDB
MMDB

KEGG

UniProtKB/TrEMBL

DrugBank
GoogleScholar
UniChem
US Patent
n/an/an/an/a 600n/an/an/an/a



Enanta Pharmaceuticals, Inc.

US Patent


Assay Description
Following extensive parameter testing, the final assay is run as follows: HEp-2 cells are seeded into the inner 60 wells of a 96-well plate at 8,000 ...


US Patent US10398706 (2019)


BindingDB Entry DOI: 10.7270/Q2M047VT
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%