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Found 40 Enz. Inhib. hit(s) with all data for entry = 8671
TargetEstrogen receptor(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM412221((1R,2S)-1-[4-[2-[3- (fluoromethyl)azetidin- 1-yl]e...)
Affinity DataEC50:  0.371nMAssay Description:The relative efficacies of Formula I compounds as inhibitors of an enzyme activity (or other biological activity) can be established by determining t...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetEstrogen receptor(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM412261((5S,6R)-5-(4-((2-((R)- 3- (fluoromethyl)pyrrolidin...)
Affinity DataEC50:  0.773nMAssay Description:The relative efficacies of Formula I compounds as inhibitors of an enzyme activity (or other biological activity) can be established by determining t...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetEstrogen receptor(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM412230((5S,6S)-5-(4-(2-(3- (fluoromethyl)azetidin- 1-yl)e...)
Affinity DataEC50:  0.164nMAssay Description:The relative efficacies of Formula I compounds as inhibitors of an enzyme activity (or other biological activity) can be established by determining t...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetEstrogen receptor(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM412231((5R,6R)-6-(4,4- difluorocyclohexyl)-5- (4-(2-(3- (...)
Affinity DataEC50:  0.177nMAssay Description:The relative efficacies of Formula I compounds as inhibitors of an enzyme activity (or other biological activity) can be established by determining t...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetEstrogen receptor(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM412232((5R,6S)-5-(4-(2-(3- (fluoromethyl)pyrrolidin- 1- y...)
Affinity DataEC50:  47nMAssay Description:The relative efficacies of Formula I compounds as inhibitors of an enzyme activity (or other biological activity) can be established by determining t...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetEstrogen receptor(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM412233((5R,6S)-5-(4-(2-(3- (chloromethyl)azetidin- 1-yl)e...)
Affinity DataEC50:  50.9nMAssay Description:The relative efficacies of Formula I compounds as inhibitors of an enzyme activity (or other biological activity) can be established by determining t...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetEstrogen receptor(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM412234((5S,6R)-5-(4-(2-(3- (chloromethyl)azetidin- 1-yl)e...)
Affinity DataEC50:  0.177nMAssay Description:The relative efficacies of Formula I compounds as inhibitors of an enzyme activity (or other biological activity) can be established by determining t...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetEstrogen receptor(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM412235((5S,6R)-5-(4-(2-(3- (fluoromethyl)pyrrolidin- 1- y...)
Affinity DataEC50:  0.100nMAssay Description:The relative efficacies of Formula I compounds as inhibitors of an enzyme activity (or other biological activity) can be established by determining t...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetEstrogen receptor(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM412236((5S,6R)-5-(4-(2-(3- (fluoromethyl)azetidin- 1-yl)e...)
Affinity DataEC50:  39.4nMAssay Description:The relative efficacies of Formula I compounds as inhibitors of an enzyme activity (or other biological activity) can be established by determining t...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetEstrogen receptor(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM412251((5R,6S)-5-(4-((1-(3- fluoropropyl)azetidin- 3-yl)o...)
Affinity DataEC50:  0.107nMAssay Description:The relative efficacies of Formula I compounds as inhibitors of an enzyme activity (or other biological activity) can be established by determining t...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetEstrogen receptor(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM412222((1S,2R)-1-[4-[2-[3- (fluoromethyl)azetidin- 1-yl]e...)
Affinity DataEC50:  8.12nMAssay Description:The relative efficacies of Formula I compounds as inhibitors of an enzyme activity (or other biological activity) can be established by determining t...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetEstrogen receptor(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM412223((1S,2R)-1-[4-[2-[3- (fluoromethyl)azetidin- 1-yl]e...)
Affinity DataEC50:  38.6nMAssay Description:The relative efficacies of Formula I compounds as inhibitors of an enzyme activity (or other biological activity) can be established by determining t...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetEstrogen receptor(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM412243((R)-1'-(4-(2-(3- (fluoromethyl)azetidin- 1-yl)etho...)
Affinity DataEC50:  0.451nMAssay Description:The relative efficacies of Formula I compounds as inhibitors of an enzyme activity (or other biological activity) can be established by determining t...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetEstrogen receptor(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM412244((5R,6S)-5-(4-((S)-2- ((R)-3- (fluoromethyl)pyrroli...)
Affinity DataEC50:  16.9nMAssay Description:The relative efficacies of Formula I compounds as inhibitors of an enzyme activity (or other biological activity) can be established by determining t...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetEstrogen receptor(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM412256((7S,8R)-8-(4-(2-(3- (fluoromethyl)azetidin- 1-yl)e...)
Affinity DataEC50:  29.8nMAssay Description:The relative efficacies of Formula I compounds as inhibitors of an enzyme activity (or other biological activity) can be established by determining t...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetEstrogen receptor(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM412257((7R,8S)-8-(4-(2-(3- (fluoromethyl)azetidin- 1-yl)e...)
Affinity DataEC50:  186nMAssay Description:The relative efficacies of Formula I compounds as inhibitors of an enzyme activity (or other biological activity) can be established by determining t...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetEstrogen receptor(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM412258((5R,6S)-5-(4-((2-(3- (fluoromethyl)azetidin- 1- yl...)
Affinity DataEC50:  186nMAssay Description:The relative efficacies of Formula I compounds as inhibitors of an enzyme activity (or other biological activity) can be established by determining t...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetEstrogen receptor(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM412259((5S,6R)-5-(4-((2-(3- (fluoromethyl)azetidin- 1- yl...)
Affinity DataEC50:  0.203nMAssay Description:The relative efficacies of Formula I compounds as inhibitors of an enzyme activity (or other biological activity) can be established by determining t...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetEstrogen receptor(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM412245((5S,6R)-5-(4-((S)-2- ((R)-3- (fluoromethyl)pyrroli...)
Affinity DataEC50:  0.0370nMAssay Description:The relative efficacies of Formula I compounds as inhibitors of an enzyme activity (or other biological activity) can be established by determining t...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetEstrogen receptor(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM412246((5R,6S)-5-(4-(((R)-1- ((R)-3- (fluoromethyl)pyrrol...)
Affinity DataEC50: >100nMAssay Description:The relative efficacies of Formula I compounds as inhibitors of an enzyme activity (or other biological activity) can be established by determining t...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetEstrogen receptor(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM412237((5S,6R)-5-(4-(2-(3- (difluoromethyl)azetidin- 1- y...)
Affinity DataEC50: >100nMAssay Description:The relative efficacies of Formula I compounds as inhibitors of an enzyme activity (or other biological activity) can be established by determining t...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetEstrogen receptor(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM412238((5R,6S)-5-(4-(2-(3- (fluoromethyl)azetidin- 1-yl)e...)
Affinity DataEC50:  0.227nMAssay Description:The relative efficacies of Formula I compounds as inhibitors of an enzyme activity (or other biological activity) can be established by determining t...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetEstrogen receptor(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM412247((5S,6R)-5-(4-(((R)-1- ((R)-3- (fluoromethyl)pyrrol...)
Affinity DataEC50:  0.675nMAssay Description:The relative efficacies of Formula I compounds as inhibitors of an enzyme activity (or other biological activity) can be established by determining t...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetEstrogen receptor(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM412248((5S,6S)-5-(6-(2-(3- (fluoromethyl)azetidin- 1-yl)e...)
Affinity DataEC50:  0.0460nMAssay Description:The relative efficacies of Formula I compounds as inhibitors of an enzyme activity (or other biological activity) can be established by determining t...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetEstrogen receptor(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM412249((5R,6R)-5-(6-(2-(3- (fluoromethyl)azetidin- 1-yl)e...)
Affinity DataEC50:  12.5nMAssay Description:The relative efficacies of Formula I compounds as inhibitors of an enzyme activity (or other biological activity) can be established by determining t...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetEstrogen receptor(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM412250((5S,6R)-5-(4-((1-(3- fluoropropyl)azetidin- 3-yl)o...)
Affinity DataEC50: >100nMAssay Description:The relative efficacies of Formula I compounds as inhibitors of an enzyme activity (or other biological activity) can be established by determining t...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetEstrogen receptor(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM412224((1R,2R)-1-[2,6- difluoro-4-[2-[3- (fluoromethyl)az...)
Affinity DataEC50:  15.6nMAssay Description:The relative efficacies of Formula I compounds as inhibitors of an enzyme activity (or other biological activity) can be established by determining t...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetEstrogen receptor(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM412225((1S,2S)-1-[2,6- difluoro-4-[2-[3- (fluoromethyl)az...)
Affinity DataEC50:  0.0400nMAssay Description:The relative efficacies of Formula I compounds as inhibitors of an enzyme activity (or other biological activity) can be established by determining t...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetEstrogen receptor(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM412226((1R,2S)-1-[4-[2-[3- (fluoromethyl)azetidin- 1-yl]e...)
Affinity DataEC50:  0.977nMAssay Description:The relative efficacies of Formula I compounds as inhibitors of an enzyme activity (or other biological activity) can be established by determining t...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetEstrogen receptor(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM412227((5R,6R)-5-(4-(2-(3- (fluoromethyl)azetidin- 1-yl)e...)
Affinity DataEC50:  16.4nMAssay Description:The relative efficacies of Formula I compounds as inhibitors of an enzyme activity (or other biological activity) can be established by determining t...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetEstrogen receptor(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM412239((5R,6S)-5-(4-(2-(3- (difluoromethyl)azetidin- 1- y...)
Affinity DataEC50:  0.184nMAssay Description:The relative efficacies of Formula I compounds as inhibitors of an enzyme activity (or other biological activity) can be established by determining t...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetEstrogen receptor(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM412240((5R,6R)-5-(2-fluoro-4- (2-(3- (fluoromethyl)azetid...)
Affinity DataEC50:  16.5nMAssay Description:The relative efficacies of Formula I compounds as inhibitors of an enzyme activity (or other biological activity) can be established by determining t...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetEstrogen receptor(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM412241((5S,6S)-5-(2-fluoro-4- (2-(3- (fluoromethyl)azetid...)
Affinity DataEC50:  0.0360nMAssay Description:The relative efficacies of Formula I compounds as inhibitors of an enzyme activity (or other biological activity) can be established by determining t...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetEstrogen receptor(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM412242((S)-1'-(4-(2-(3- (fluoromethyl)azetidin- 1-yl)etho...)
Affinity DataEC50:  0.208nMAssay Description:The relative efficacies of Formula I compounds as inhibitors of an enzyme activity (or other biological activity) can be established by determining t...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetEstrogen receptor(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM412252((5S,6R)-5-(4-((1-(3- fluoropropyl)azetidin- 3-yl)a...)
Affinity DataEC50:  13.8nMAssay Description:The relative efficacies of Formula I compounds as inhibitors of an enzyme activity (or other biological activity) can be established by determining t...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetEstrogen receptor(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM412253((5R,6S)-5-(4-((1-(3- fluoropropyl)azetidin- 3-yl)a...)
Affinity DataEC50:  0.0290nMAssay Description:The relative efficacies of Formula I compounds as inhibitors of an enzyme activity (or other biological activity) can be established by determining t...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetEstrogen receptor(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM412254(4-((1R,2S)-1-(4-(2-(3- (fluoromethyl)azetidin- 1-y...)
Affinity DataEC50:  53nMAssay Description:The relative efficacies of Formula I compounds as inhibitors of an enzyme activity (or other biological activity) can be established by determining t...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetEstrogen receptor(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM412255(4-((1S,2R)-1-(4-(2-(3- (fluoromethyl)azetidin- 1-y...)
Affinity DataEC50:  0.0380nMAssay Description:The relative efficacies of Formula I compounds as inhibitors of an enzyme activity (or other biological activity) can be established by determining t...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetEstrogen receptor(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM412260((5R,6S)-5-(4-((2-((R)- 3- (fluoromethyl)pyrrolidin...)
Affinity DataEC50:  228nMAssay Description:The relative efficacies of Formula I compounds as inhibitors of an enzyme activity (or other biological activity) can be established by determining t...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetEstrogen receptor(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM412228((5S,6S)-6-(4,4- difluorocyclohexyl)-5- (4-(2-(3- (...)
Affinity DataEC50:  14.6nMAssay Description:The relative efficacies of Formula I compounds as inhibitors of an enzyme activity (or other biological activity) can be established by determining t...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent