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Patent code US10399948

Compile Data Set for Download or QSAR
Found 138 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Metabotropic glutamate receptor 3


(Rattus norvegicus (Rat))
BDBM50278642
PNG
(CHEMBL4164285 | US10399948, Compound 17)
Show SMILES Fc1ccc(cc1)-n1ccc(OCCOc2ccccc2)nc1=O
Show InChI InChI=1S/C18H15FN2O3/c19-14-6-8-15(9-7-14)21-11-10-17(20-18(21)22)24-13-12-23-16-4-2-1-3-5-16/h1-11H,12-13H2
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n/an/a 211n/an/an/an/an/an/a



Vanderbilt University

US Patent


Assay Description
Gα15/TREx cells stably expressing rat mGlu3 were plated in black-walled, clear-bottomed, poly-D-lysine coated 384-well plates in 20 μL of a...


US Patent US10399948 (2019)


BindingDB Entry DOI: 10.7270/Q2794726
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 3


(Rattus norvegicus (Rat))
BDBM50278654
PNG
(CHEMBL4174544 | US10399948, Compound 15)
Show SMILES Fc1ccc(cc1F)-n1ccc(OCCOc2ccccc2)nc1=O
Show InChI InChI=1S/C18H14F2N2O3/c19-15-7-6-13(12-16(15)20)22-9-8-17(21-18(22)23)25-11-10-24-14-4-2-1-3-5-14/h1-9,12H,10-11H2
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n/an/a 219n/an/an/an/an/an/a



Vanderbilt University

US Patent


Assay Description
Gα15/TREx cells stably expressing rat mGlu3 were plated in black-walled, clear-bottomed, poly-D-lysine coated 384-well plates in 20 μL of a...


US Patent US10399948 (2019)


BindingDB Entry DOI: 10.7270/Q2794726
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 3


(Rattus norvegicus (Rat))
BDBM50278641
PNG
(CHEMBL4174935 | US10399948, Compound 14)
Show SMILES Fc1cccc(c1)-n1ccc(OCCOc2ccccc2)nc1=O
Show InChI InChI=1S/C18H15FN2O3/c19-14-5-4-6-15(13-14)21-10-9-17(20-18(21)22)24-12-11-23-16-7-2-1-3-8-16/h1-10,13H,11-12H2
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Vanderbilt University

US Patent


Assay Description
Gα15/TREx cells stably expressing rat mGlu3 were plated in black-walled, clear-bottomed, poly-D-lysine coated 384-well plates in 20 μL of a...


US Patent US10399948 (2019)


BindingDB Entry DOI: 10.7270/Q2794726
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 3


(Rattus norvegicus (Rat))
BDBM50278653
PNG
(CHEMBL4163186 | US10399948, Compound 20)
Show SMILES Fc1ccc(cc1F)-n1ccc(OCCOc2ccccc2)cc1=O
Show InChI InChI=1S/C19H15F2NO3/c20-17-7-6-14(12-18(17)21)22-9-8-16(13-19(22)23)25-11-10-24-15-4-2-1-3-5-15/h1-9,12-13H,10-11H2
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Vanderbilt University

US Patent


Assay Description
Gα15/TREx cells stably expressing rat mGlu3 were plated in black-walled, clear-bottomed, poly-D-lysine coated 384-well plates in 20 μL of a...


US Patent US10399948 (2019)


BindingDB Entry DOI: 10.7270/Q2794726
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(Rattus norvegicus (Rat))
BDBM50278653
PNG
(CHEMBL4163186 | US10399948, Compound 20)
Show SMILES Fc1ccc(cc1F)-n1ccc(OCCOc2ccccc2)cc1=O
Show InChI InChI=1S/C19H15F2NO3/c20-17-7-6-14(12-18(17)21)22-9-8-16(13-19(22)23)25-11-10-24-15-4-2-1-3-5-15/h1-9,12-13H,10-11H2
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Vanderbilt University

US Patent


Assay Description
HEK 293A cells stably expressing rat mGlu5 were plated in black-walled, clear-bottomed, poly-D-lysine coated 384-well plates in 20 μL of assay m...


US Patent US10399948 (2019)


BindingDB Entry DOI: 10.7270/Q2794726
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(Rattus norvegicus (Rat))
BDBM50278654
PNG
(CHEMBL4174544 | US10399948, Compound 15)
Show SMILES Fc1ccc(cc1F)-n1ccc(OCCOc2ccccc2)nc1=O
Show InChI InChI=1S/C18H14F2N2O3/c19-15-7-6-13(12-16(15)20)22-9-8-17(21-18(22)23)25-11-10-24-14-4-2-1-3-5-14/h1-9,12H,10-11H2
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Vanderbilt University

US Patent


Assay Description
HEK 293A cells stably expressing rat mGlu5 were plated in black-walled, clear-bottomed, poly-D-lysine coated 384-well plates in 20 μL of assay m...


US Patent US10399948 (2019)


BindingDB Entry DOI: 10.7270/Q2794726
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 3


(Rattus norvegicus (Rat))
BDBM50278643
PNG
(CHEMBL4171110 | US10399948, Compound 19)
Show SMILES Fc1cccc(c1)-n1ccc(OCCOc2ccccc2)cc1=O
Show InChI InChI=1S/C19H16FNO3/c20-15-5-4-6-16(13-15)21-10-9-18(14-19(21)22)24-12-11-23-17-7-2-1-3-8-17/h1-10,13-14H,11-12H2
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n/an/a 434n/an/an/an/an/an/a



Vanderbilt University

US Patent


Assay Description
Gα15/TREx cells stably expressing rat mGlu3 were plated in black-walled, clear-bottomed, poly-D-lysine coated 384-well plates in 20 μL of a...


US Patent US10399948 (2019)


BindingDB Entry DOI: 10.7270/Q2794726
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 3


(Rattus norvegicus (Rat))
BDBM50278640
PNG
(CHEMBL4160819 | US10399948, Compound 54)
Show SMILES Fc1ccc(cc1)-n1ccc(OCCOc2ncccc2Cl)cc1=O
Show InChI InChI=1S/C18H14ClFN2O3/c19-16-2-1-8-21-18(16)25-11-10-24-15-7-9-22(17(23)12-15)14-5-3-13(20)4-6-14/h1-9,12H,10-11H2
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n/an/a 443n/an/an/an/an/an/a



Vanderbilt University

US Patent


Assay Description
Gα15/TREx cells stably expressing rat mGlu3 were plated in black-walled, clear-bottomed, poly-D-lysine coated 384-well plates in 20 μL of a...


US Patent US10399948 (2019)


BindingDB Entry DOI: 10.7270/Q2794726
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 3


(Rattus norvegicus (Rat))
BDBM50278655
PNG
(CHEMBL4171435 | US10399948, Compound 31)
Show SMILES Fc1ccc(cc1)-n1ccc(OCCOc2cccc(F)c2)cc1=O
Show InChI InChI=1S/C19H15F2NO3/c20-14-4-6-16(7-5-14)22-9-8-18(13-19(22)23)25-11-10-24-17-3-1-2-15(21)12-17/h1-9,12-13H,10-11H2
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Vanderbilt University

US Patent


Assay Description
Gα15/TREx cells stably expressing rat mGlu3 were plated in black-walled, clear-bottomed, poly-D-lysine coated 384-well plates in 20 μL of a...


US Patent US10399948 (2019)


BindingDB Entry DOI: 10.7270/Q2794726
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 3


(Rattus norvegicus (Rat))
BDBM50278634
PNG
(CHEMBL4173490 | US10399948, Compound 23)
Show SMILES Fc1cc(cc(c1)-n1ccc(OCCOc2ccccc2)cc1=O)C#N
Show InChI InChI=1S/C20H15FN2O3/c21-16-10-15(14-22)11-17(12-16)23-7-6-19(13-20(23)24)26-9-8-25-18-4-2-1-3-5-18/h1-7,10-13H,8-9H2
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Vanderbilt University

US Patent


Assay Description
Gα15/TREx cells stably expressing rat mGlu3 were plated in black-walled, clear-bottomed, poly-D-lysine coated 384-well plates in 20 μL of a...


US Patent US10399948 (2019)


BindingDB Entry DOI: 10.7270/Q2794726
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 3


(Rattus norvegicus (Rat))
BDBM50278631
PNG
(CHEMBL4162785 | US10399948, Compound 22)
Show SMILES O=c1cc(OCCOc2ccccc2)ccn1-c1cccc(c1)C#N
Show InChI InChI=1S/C20H16N2O3/c21-15-16-5-4-6-17(13-16)22-10-9-19(14-20(22)23)25-12-11-24-18-7-2-1-3-8-18/h1-10,13-14H,11-12H2
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Vanderbilt University

US Patent


Assay Description
Gα15/TREx cells stably expressing rat mGlu3 were plated in black-walled, clear-bottomed, poly-D-lysine coated 384-well plates in 20 μL of a...


US Patent US10399948 (2019)


BindingDB Entry DOI: 10.7270/Q2794726
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 3


(Rattus norvegicus (Rat))
BDBM50278661
PNG
(CHEMBL4174878 | US10399948, Compound 49)
Show SMILES Fc1ccc(cc1)-n1ccc(OCCOc2cc(Cl)ccn2)cc1=O
Show InChI InChI=1S/C18H14ClFN2O3/c19-13-5-7-21-17(11-13)25-10-9-24-16-6-8-22(18(23)12-16)15-3-1-14(20)2-4-15/h1-8,11-12H,9-10H2
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Vanderbilt University

US Patent


Assay Description
Gα15/TREx cells stably expressing rat mGlu3 were plated in black-walled, clear-bottomed, poly-D-lysine coated 384-well plates in 20 μL of a...


US Patent US10399948 (2019)


BindingDB Entry DOI: 10.7270/Q2794726
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(Rattus norvegicus (Rat))
BDBM50278633
PNG
(CHEMBL4166631 | US10399948, Compound 18)
Show SMILES Fc1ccc(cc1)-n1ccc(OCCOc2ccccc2)cc1=O
Show InChI InChI=1S/C19H16FNO3/c20-15-6-8-16(9-7-15)21-11-10-18(14-19(21)22)24-13-12-23-17-4-2-1-3-5-17/h1-11,14H,12-13H2
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Vanderbilt University

US Patent


Assay Description
HEK 293A cells stably expressing rat mGlu5 were plated in black-walled, clear-bottomed, poly-D-lysine coated 384-well plates in 20 μL of assay m...


US Patent US10399948 (2019)


BindingDB Entry DOI: 10.7270/Q2794726
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 3


(Rattus norvegicus (Rat))
BDBM417088
PNG
(4-(2-(4-chlorophenoxy)ethoxy)-1-(4-fluorophenyl)py...)
Show SMILES Fc1ccc(cc1)-n1ccc(OCCOc2ccc(Cl)cc2)cc1=O
Show InChI InChI=1S/C19H15ClFNO3/c20-14-1-7-17(8-2-14)24-11-12-25-18-9-10-22(19(23)13-18)16-5-3-15(21)4-6-16/h1-10,13H,11-12H2
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US Patent


Assay Description
Gα15/TREx cells stably expressing rat mGlu3 were plated in black-walled, clear-bottomed, poly-D-lysine coated 384-well plates in 20 μL of a...


US Patent US10399948 (2019)


BindingDB Entry DOI: 10.7270/Q2794726
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 3


(Rattus norvegicus (Rat))
BDBM417094
PNG
(1-(4-fluorophenyl)-4-(2-((6-fluoropyridin-3-yl)oxy...)
Show SMILES Fc1ccc(cc1)-n1ccc(OCCOc2ccc(F)nc2)cc1=O
Show InChI InChI=1S/C18H14F2N2O3/c19-13-1-3-14(4-2-13)22-8-7-15(11-18(22)23)24-9-10-25-16-5-6-17(20)21-12-16/h1-8,11-12H,9-10H2
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Vanderbilt University

US Patent


Assay Description
Gα15/TREx cells stably expressing rat mGlu3 were plated in black-walled, clear-bottomed, poly-D-lysine coated 384-well plates in 20 μL of a...


US Patent US10399948 (2019)


BindingDB Entry DOI: 10.7270/Q2794726
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 3


(Rattus norvegicus (Rat))
BDBM417090
PNG
(3-(2-((1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridin...)
Show SMILES Fc1ccc(cc1)-n1ccc(OCCOc2cccc(c2)C#N)cc1=O
Show InChI InChI=1S/C20H15FN2O3/c21-16-4-6-17(7-5-16)23-9-8-19(13-20(23)24)26-11-10-25-18-3-1-2-15(12-18)14-22/h1-9,12-13H,10-11H2
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Vanderbilt University

US Patent


Assay Description
Gα15/TREx cells stably expressing rat mGlu3 were plated in black-walled, clear-bottomed, poly-D-lysine coated 384-well plates in 20 μL of a...


US Patent US10399948 (2019)


BindingDB Entry DOI: 10.7270/Q2794726
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 3


(Rattus norvegicus (Rat))
BDBM50278633
PNG
(CHEMBL4166631 | US10399948, Compound 18)
Show SMILES Fc1ccc(cc1)-n1ccc(OCCOc2ccccc2)cc1=O
Show InChI InChI=1S/C19H16FNO3/c20-15-6-8-16(9-7-15)21-11-10-18(14-19(21)22)24-13-12-23-17-4-2-1-3-5-17/h1-11,14H,12-13H2
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US Patent


Assay Description
Gα15/TREx cells stably expressing rat mGlu3 were plated in black-walled, clear-bottomed, poly-D-lysine coated 384-well plates in 20 μL of a...


US Patent US10399948 (2019)


BindingDB Entry DOI: 10.7270/Q2794726
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 3


(Rattus norvegicus (Rat))
BDBM50278632
PNG
(CHEMBL4164219 | US10399948, Compound 1)
Show SMILES CC(COc1ccn(-c2ccc(F)cc2)c(=O)c1)Oc1ccccc1
Show InChI InChI=1S/C20H18FNO3/c1-15(25-18-5-3-2-4-6-18)14-24-19-11-12-22(20(23)13-19)17-9-7-16(21)8-10-17/h2-13,15H,14H2,1H3
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Vanderbilt University

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Assay Description
Gα15/TREx cells stably expressing rat mGlu3 were plated in black-walled, clear-bottomed, poly-D-lysine coated 384-well plates in 20 μL of a...


US Patent US10399948 (2019)


BindingDB Entry DOI: 10.7270/Q2794726
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 3


(Rattus norvegicus (Rat))
BDBM417109
PNG
(4-(2-((5-chloropyridin-2-yl)oxy)ethoxy)-1-(4-fluor...)
Show SMILES Fc1ccc(cc1)-n1ccc(OCCOc2ccc(Cl)cn2)cc1=O
Show InChI InChI=1S/C18H14ClFN2O3/c19-13-1-6-17(21-12-13)25-10-9-24-16-7-8-22(18(23)11-16)15-4-2-14(20)3-5-15/h1-8,11-12H,9-10H2
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Vanderbilt University

US Patent


Assay Description
Gα15/TREx cells stably expressing rat mGlu3 were plated in black-walled, clear-bottomed, poly-D-lysine coated 384-well plates in 20 μL of a...


US Patent US10399948 (2019)


BindingDB Entry DOI: 10.7270/Q2794726
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 3


(Rattus norvegicus (Rat))
BDBM417113
PNG
(2-(2-((1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridin...)
Show SMILES Fc1ccc(cc1)-n1ccc(OCCOc2cc(ccn2)C#N)cc1=O
Show InChI InChI=1S/C19H14FN3O3/c20-15-1-3-16(4-2-15)23-8-6-17(12-19(23)24)25-9-10-26-18-11-14(13-21)5-7-22-18/h1-8,11-12H,9-10H2
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Vanderbilt University

US Patent


Assay Description
Gα15/TREx cells stably expressing rat mGlu3 were plated in black-walled, clear-bottomed, poly-D-lysine coated 384-well plates in 20 μL of a...


US Patent US10399948 (2019)


BindingDB Entry DOI: 10.7270/Q2794726
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 3


(Rattus norvegicus (Rat))
BDBM417069
PNG
(1-(3,5-difluorophenyl)-4-(2-phenoxyethoxy)pyridin-...)
Show SMILES Fc1cc(F)cc(c1)-n1ccc(OCCOc2ccccc2)cc1=O
Show InChI InChI=1S/C19H15F2NO3/c20-14-10-15(21)12-16(11-14)22-7-6-18(13-19(22)23)25-9-8-24-17-4-2-1-3-5-17/h1-7,10-13H,8-9H2
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n/an/a 799n/an/an/an/an/an/a



Vanderbilt University

US Patent


Assay Description
Gα15/TREx cells stably expressing rat mGlu3 were plated in black-walled, clear-bottomed, poly-D-lysine coated 384-well plates in 20 μL of a...


US Patent US10399948 (2019)


BindingDB Entry DOI: 10.7270/Q2794726
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(Rattus norvegicus (Rat))
BDBM417069
PNG
(1-(3,5-difluorophenyl)-4-(2-phenoxyethoxy)pyridin-...)
Show SMILES Fc1cc(F)cc(c1)-n1ccc(OCCOc2ccccc2)cc1=O
Show InChI InChI=1S/C19H15F2NO3/c20-14-10-15(21)12-16(11-14)22-7-6-18(13-19(22)23)25-9-8-24-17-4-2-1-3-5-17/h1-7,10-13H,8-9H2
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n/an/a 818n/an/an/an/an/an/a



Vanderbilt University

US Patent


Assay Description
HEK 293A cells stably expressing rat mGlu5 were plated in black-walled, clear-bottomed, poly-D-lysine coated 384-well plates in 20 μL of assay m...


US Patent US10399948 (2019)


BindingDB Entry DOI: 10.7270/Q2794726
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 3


(Rattus norvegicus (Rat))
BDBM417079
PNG
(4-(2-(2-fluorophenoxy)ethoxy)-1-(4-fluorophenyl)py...)
Show SMILES Fc1ccc(cc1)-n1ccc(OCCOc2ccccc2F)cc1=O
Show InChI InChI=1S/C19H15F2NO3/c20-14-5-7-15(8-6-14)22-10-9-16(13-19(22)23)24-11-12-25-18-4-2-1-3-17(18)21/h1-10,13H,11-12H2
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Vanderbilt University

US Patent


Assay Description
Gα15/TREx cells stably expressing rat mGlu3 were plated in black-walled, clear-bottomed, poly-D-lysine coated 384-well plates in 20 μL of a...


US Patent US10399948 (2019)


BindingDB Entry DOI: 10.7270/Q2794726
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 3


(Rattus norvegicus (Rat))
BDBM417082
PNG
(4-(2-(2,3-difluorophenoxy)ethoxy)-1-(4-fluoropheny...)
Show SMILES Fc1ccc(cc1)-n1ccc(OCCOc2cccc(F)c2F)cc1=O
Show InChI InChI=1S/C19H14F3NO3/c20-13-4-6-14(7-5-13)23-9-8-15(12-18(23)24)25-10-11-26-17-3-1-2-16(21)19(17)22/h1-9,12H,10-11H2
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Vanderbilt University

US Patent


Assay Description
Gα15/TREx cells stably expressing rat mGlu3 were plated in black-walled, clear-bottomed, poly-D-lysine coated 384-well plates in 20 μL of a...


US Patent US10399948 (2019)


BindingDB Entry DOI: 10.7270/Q2794726
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 3


(Rattus norvegicus (Rat))
BDBM417087
PNG
(4-(2-(3-chlorophenoxy)ethoxy)-1-(4-fluorophenyl)py...)
Show SMILES Fc1ccc(cc1)-n1ccc(OCCOc2cccc(Cl)c2)cc1=O
Show InChI InChI=1S/C19H15ClFNO3/c20-14-2-1-3-17(12-14)24-10-11-25-18-8-9-22(19(23)13-18)16-6-4-15(21)5-7-16/h1-9,12-13H,10-11H2
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Vanderbilt University

US Patent


Assay Description
Gα15/TREx cells stably expressing rat mGlu3 were plated in black-walled, clear-bottomed, poly-D-lysine coated 384-well plates in 20 μL of a...


US Patent US10399948 (2019)


BindingDB Entry DOI: 10.7270/Q2794726
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 3


(Rattus norvegicus (Rat))
BDBM417081
PNG
(4-(2-(4-fluorophenoxy)ethoxy)-1-(4-fluorophenyl)py...)
Show SMILES Fc1ccc(OCCOc2ccn(-c3ccc(F)cc3)c(=O)c2)cc1
Show InChI InChI=1S/C19H15F2NO3/c20-14-1-5-16(6-2-14)22-10-9-18(13-19(22)23)25-12-11-24-17-7-3-15(21)4-8-17/h1-10,13H,11-12H2
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n/an/a 1.05E+3n/an/an/an/an/an/a



Vanderbilt University

US Patent


Assay Description
Gα15/TREx cells stably expressing rat mGlu3 were plated in black-walled, clear-bottomed, poly-D-lysine coated 384-well plates in 20 μL of a...


US Patent US10399948 (2019)


BindingDB Entry DOI: 10.7270/Q2794726
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 3


(Rattus norvegicus (Rat))
BDBM417106
PNG
(1-(4-fluorophenyl)-4-(2-((5-fluoropyridin-2-yl)oxy...)
Show SMILES Fc1ccc(cc1)-n1ccc(OCCOc2ccc(F)cn2)cc1=O
Show InChI InChI=1S/C18H14F2N2O3/c19-13-1-4-15(5-2-13)22-8-7-16(11-18(22)23)24-9-10-25-17-6-3-14(20)12-21-17/h1-8,11-12H,9-10H2
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n/an/a 1.06E+3n/an/an/an/an/an/a



Vanderbilt University

US Patent


Assay Description
Gα15/TREx cells stably expressing rat mGlu3 were plated in black-walled, clear-bottomed, poly-D-lysine coated 384-well plates in 20 μL of a...


US Patent US10399948 (2019)


BindingDB Entry DOI: 10.7270/Q2794726
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 3


(Rattus norvegicus (Rat))
BDBM417091
PNG
(4-(2-((1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridin...)
Show SMILES Fc1ccc(cc1)-n1ccc(OCCOc2ccc(cc2)C#N)cc1=O
Show InChI InChI=1S/C20H15FN2O3/c21-16-3-5-17(6-4-16)23-10-9-19(13-20(23)24)26-12-11-25-18-7-1-15(14-22)2-8-18/h1-10,13H,11-12H2
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n/an/a 1.13E+3n/an/an/an/an/an/a



Vanderbilt University

US Patent


Assay Description
Gα15/TREx cells stably expressing rat mGlu3 were plated in black-walled, clear-bottomed, poly-D-lysine coated 384-well plates in 20 μL of a...


US Patent US10399948 (2019)


BindingDB Entry DOI: 10.7270/Q2794726
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 3


(Rattus norvegicus (Rat))
BDBM417053
PNG
(1-(4-fluorophenyl)-4-((1-phenoxypropan-2-yl)oxy)py...)
Show SMILES CC(COc1ccccc1)Oc1ccn(-c2ccc(F)cc2)c(=O)c1
Show InChI InChI=1S/C20H18FNO3/c1-15(14-24-18-5-3-2-4-6-18)25-19-11-12-22(20(23)13-19)17-9-7-16(21)8-10-17/h2-13,15H,14H2,1H3
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n/an/a 1.16E+3n/an/an/an/an/an/a



Vanderbilt University

US Patent


Assay Description
Gα15/TREx cells stably expressing rat mGlu3 were plated in black-walled, clear-bottomed, poly-D-lysine coated 384-well plates in 20 μL of a...


US Patent US10399948 (2019)


BindingDB Entry DOI: 10.7270/Q2794726
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(Rattus norvegicus (Rat))
BDBM50278642
PNG
(CHEMBL4164285 | US10399948, Compound 17)
Show SMILES Fc1ccc(cc1)-n1ccc(OCCOc2ccccc2)nc1=O
Show InChI InChI=1S/C18H15FN2O3/c19-14-6-8-15(9-7-14)21-11-10-17(20-18(21)22)24-13-12-23-16-4-2-1-3-5-16/h1-11H,12-13H2
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Vanderbilt University

US Patent


Assay Description
HEK 293A cells stably expressing rat mGlu5 were plated in black-walled, clear-bottomed, poly-D-lysine coated 384-well plates in 20 μL of assay m...


US Patent US10399948 (2019)


BindingDB Entry DOI: 10.7270/Q2794726
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(Rattus norvegicus (Rat))
BDBM417077
PNG
(3-(4-Fluorophenyl)-6-(2-phenoxyethoxy)pyrimidin-4(...)
Show SMILES Fc1ccc(cc1)-n1cnc(OCCOc2ccccc2)cc1=O
Show InChI InChI=1S/C18H15FN2O3/c19-14-6-8-15(9-7-14)21-13-20-17(12-18(21)22)24-11-10-23-16-4-2-1-3-5-16/h1-9,12-13H,10-11H2
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Vanderbilt University

US Patent


Assay Description
HEK 293A cells stably expressing rat mGlu5 were plated in black-walled, clear-bottomed, poly-D-lysine coated 384-well plates in 20 μL of assay m...


US Patent US10399948 (2019)


BindingDB Entry DOI: 10.7270/Q2794726
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 3


(Rattus norvegicus (Rat))
BDBM417077
PNG
(3-(4-Fluorophenyl)-6-(2-phenoxyethoxy)pyrimidin-4(...)
Show SMILES Fc1ccc(cc1)-n1cnc(OCCOc2ccccc2)cc1=O
Show InChI InChI=1S/C18H15FN2O3/c19-14-6-8-15(9-7-14)21-13-20-17(12-18(21)22)24-11-10-23-16-4-2-1-3-5-16/h1-9,12-13H,10-11H2
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n/an/a 1.27E+3n/an/an/an/an/an/a



Vanderbilt University

US Patent


Assay Description
Gα15/TREx cells stably expressing rat mGlu3 were plated in black-walled, clear-bottomed, poly-D-lysine coated 384-well plates in 20 μL of a...


US Patent US10399948 (2019)


BindingDB Entry DOI: 10.7270/Q2794726
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 3


(Rattus norvegicus (Rat))
BDBM417104
PNG
(1-(4-fluorophenyl)-4-(2-((3-fluoropyridin-2-yl)oxy...)
Show SMILES Fc1ccc(cc1)-n1ccc(OCCOc2ncccc2F)cc1=O
Show InChI InChI=1S/C18H14F2N2O3/c19-13-3-5-14(6-4-13)22-9-7-15(12-17(22)23)24-10-11-25-18-16(20)2-1-8-21-18/h1-9,12H,10-11H2
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n/an/a 1.28E+3n/an/an/an/an/an/a



Vanderbilt University

US Patent


Assay Description
Gα15/TREx cells stably expressing rat mGlu3 were plated in black-walled, clear-bottomed, poly-D-lysine coated 384-well plates in 20 μL of a...


US Patent US10399948 (2019)


BindingDB Entry DOI: 10.7270/Q2794726
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(Rattus norvegicus (Rat))
BDBM50278634
PNG
(CHEMBL4173490 | US10399948, Compound 23)
Show SMILES Fc1cc(cc(c1)-n1ccc(OCCOc2ccccc2)cc1=O)C#N
Show InChI InChI=1S/C20H15FN2O3/c21-16-10-15(14-22)11-17(12-16)23-7-6-19(13-20(23)24)26-9-8-25-18-4-2-1-3-5-18/h1-7,10-13H,8-9H2
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Vanderbilt University

US Patent


Assay Description
HEK 293A cells stably expressing rat mGlu5 were plated in black-walled, clear-bottomed, poly-D-lysine coated 384-well plates in 20 μL of assay m...


US Patent US10399948 (2019)


BindingDB Entry DOI: 10.7270/Q2794726
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 3


(Rattus norvegicus (Rat))
BDBM417114
PNG
(6-(2-((1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridin...)
Show SMILES Fc1ccc(cc1)-n1ccc(OCCOc2ccc(cn2)C#N)cc1=O
Show InChI InChI=1S/C19H14FN3O3/c20-15-2-4-16(5-3-15)23-8-7-17(11-19(23)24)25-9-10-26-18-6-1-14(12-21)13-22-18/h1-8,11,13H,9-10H2
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Vanderbilt University

US Patent


Assay Description
Gα15/TREx cells stably expressing rat mGlu3 were plated in black-walled, clear-bottomed, poly-D-lysine coated 384-well plates in 20 μL of a...


US Patent US10399948 (2019)


BindingDB Entry DOI: 10.7270/Q2794726
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 3


(Rattus norvegicus (Rat))
BDBM417083
PNG
(4-(2-(2,4-difluorophenoxy)ethoxy)-1-(4-fluoropheny...)
Show SMILES Fc1ccc(cc1)-n1ccc(OCCOc2ccc(F)cc2F)cc1=O
Show InChI InChI=1S/C19H14F3NO3/c20-13-1-4-15(5-2-13)23-8-7-16(12-19(23)24)25-9-10-26-18-6-3-14(21)11-17(18)22/h1-8,11-12H,9-10H2
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Vanderbilt University

US Patent


Assay Description
Gα15/TREx cells stably expressing rat mGlu3 were plated in black-walled, clear-bottomed, poly-D-lysine coated 384-well plates in 20 μL of a...


US Patent US10399948 (2019)


BindingDB Entry DOI: 10.7270/Q2794726
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 3


(Rattus norvegicus (Rat))
BDBM417084
PNG
(4-(2-(2,5-difluorophenoxy)ethoxy)-1-(4-fluoropheny...)
Show SMILES Fc1ccc(cc1)-n1ccc(OCCOc2cc(F)ccc2F)cc1=O
Show InChI InChI=1S/C19H14F3NO3/c20-13-1-4-15(5-2-13)23-8-7-16(12-19(23)24)25-9-10-26-18-11-14(21)3-6-17(18)22/h1-8,11-12H,9-10H2
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Vanderbilt University

US Patent


Assay Description
Gα15/TREx cells stably expressing rat mGlu3 were plated in black-walled, clear-bottomed, poly-D-lysine coated 384-well plates in 20 μL of a...


US Patent US10399948 (2019)


BindingDB Entry DOI: 10.7270/Q2794726
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(Rattus norvegicus (Rat))
BDBM50278655
PNG
(CHEMBL4171435 | US10399948, Compound 31)
Show SMILES Fc1ccc(cc1)-n1ccc(OCCOc2cccc(F)c2)cc1=O
Show InChI InChI=1S/C19H15F2NO3/c20-14-4-6-16(7-5-14)22-9-8-18(13-19(22)23)25-11-10-24-17-3-1-2-15(21)12-17/h1-9,12-13H,10-11H2
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Assay Description
HEK 293A cells stably expressing rat mGlu5 were plated in black-walled, clear-bottomed, poly-D-lysine coated 384-well plates in 20 μL of assay m...


US Patent US10399948 (2019)


BindingDB Entry DOI: 10.7270/Q2794726
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(Rattus norvegicus (Rat))
BDBM417081
PNG
(4-(2-(4-fluorophenoxy)ethoxy)-1-(4-fluorophenyl)py...)
Show SMILES Fc1ccc(OCCOc2ccn(-c3ccc(F)cc3)c(=O)c2)cc1
Show InChI InChI=1S/C19H15F2NO3/c20-14-1-5-16(6-2-14)22-10-9-18(13-19(22)23)25-12-11-24-17-7-3-15(21)4-8-17/h1-10,13H,11-12H2
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Vanderbilt University

US Patent


Assay Description
HEK 293A cells stably expressing rat mGlu5 were plated in black-walled, clear-bottomed, poly-D-lysine coated 384-well plates in 20 μL of assay m...


US Patent US10399948 (2019)


BindingDB Entry DOI: 10.7270/Q2794726
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 3


(Rattus norvegicus (Rat))
BDBM417086
PNG
(4-(2-(2-chlorophenoxy)ethoxy)-1-(4-fluorophenyl)py...)
Show SMILES Fc1ccc(cc1)-n1ccc(OCCOc2ccccc2Cl)cc1=O
Show InChI InChI=1S/C19H15ClFNO3/c20-17-3-1-2-4-18(17)25-12-11-24-16-9-10-22(19(23)13-16)15-7-5-14(21)6-8-15/h1-10,13H,11-12H2
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n/an/a 1.84E+3n/an/an/an/an/an/a



Vanderbilt University

US Patent


Assay Description
Gα15/TREx cells stably expressing rat mGlu3 were plated in black-walled, clear-bottomed, poly-D-lysine coated 384-well plates in 20 μL of a...


US Patent US10399948 (2019)


BindingDB Entry DOI: 10.7270/Q2794726
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 3


(Rattus norvegicus (Rat))
BDBM417076
PNG
(5'-fluoro-4-(2-phenoxyethoxy)-2H-[1,3'-bipyridin]-...)
Show SMILES Fc1cncc(c1)-n1ccc(OCCOc2ccccc2)cc1=O
Show InChI InChI=1S/C18H15FN2O3/c19-14-10-15(13-20-12-14)21-7-6-17(11-18(21)22)24-9-8-23-16-4-2-1-3-5-16/h1-7,10-13H,8-9H2
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Vanderbilt University

US Patent


Assay Description
Gα15/TREx cells stably expressing rat mGlu3 were plated in black-walled, clear-bottomed, poly-D-lysine coated 384-well plates in 20 μL of a...


US Patent US10399948 (2019)


BindingDB Entry DOI: 10.7270/Q2794726
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(Rattus norvegicus (Rat))
BDBM417079
PNG
(4-(2-(2-fluorophenoxy)ethoxy)-1-(4-fluorophenyl)py...)
Show SMILES Fc1ccc(cc1)-n1ccc(OCCOc2ccccc2F)cc1=O
Show InChI InChI=1S/C19H15F2NO3/c20-14-5-7-15(8-6-14)22-10-9-16(13-19(22)23)24-11-12-25-18-4-2-1-3-17(18)21/h1-10,13H,11-12H2
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Assay Description
HEK 293A cells stably expressing rat mGlu5 were plated in black-walled, clear-bottomed, poly-D-lysine coated 384-well plates in 20 μL of assay m...


US Patent US10399948 (2019)


BindingDB Entry DOI: 10.7270/Q2794726
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 3


(Rattus norvegicus (Rat))
BDBM417101
PNG
(1-(4-fluorophenyl)-4-(2-(pyridin-2-yloxy)ethoxy)py...)
Show SMILES Fc1ccc(cc1)-n1ccc(OCCOc2ccccn2)cc1=O
Show InChI InChI=1S/C18H15FN2O3/c19-14-4-6-15(7-5-14)21-10-8-16(13-18(21)22)23-11-12-24-17-3-1-2-9-20-17/h1-10,13H,11-12H2
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Vanderbilt University

US Patent


Assay Description
Gα15/TREx cells stably expressing rat mGlu3 were plated in black-walled, clear-bottomed, poly-D-lysine coated 384-well plates in 20 μL of a...


US Patent US10399948 (2019)


BindingDB Entry DOI: 10.7270/Q2794726
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(Rattus norvegicus (Rat))
BDBM50278643
PNG
(CHEMBL4171110 | US10399948, Compound 19)
Show SMILES Fc1cccc(c1)-n1ccc(OCCOc2ccccc2)cc1=O
Show InChI InChI=1S/C19H16FNO3/c20-15-5-4-6-16(13-15)21-10-9-18(14-19(21)22)24-12-11-23-17-7-2-1-3-8-17/h1-10,13-14H,11-12H2
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US Patent


Assay Description
HEK 293A cells stably expressing rat mGlu5 were plated in black-walled, clear-bottomed, poly-D-lysine coated 384-well plates in 20 μL of assay m...


US Patent US10399948 (2019)


BindingDB Entry DOI: 10.7270/Q2794726
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 3


(Rattus norvegicus (Rat))
BDBM417096
PNG
(4-(2-((5-chloropyridin-3-yl)oxy)ethoxy)-1-(4-fluor...)
Show SMILES Fc1ccc(cc1)-n1ccc(OCCOc2cncc(Cl)c2)cc1=O
Show InChI InChI=1S/C18H14ClFN2O3/c19-13-9-17(12-21-11-13)25-8-7-24-16-5-6-22(18(23)10-16)15-3-1-14(20)2-4-15/h1-6,9-12H,7-8H2
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n/an/a 2.79E+3n/an/an/an/an/an/a



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US Patent


Assay Description
Gα15/TREx cells stably expressing rat mGlu3 were plated in black-walled, clear-bottomed, poly-D-lysine coated 384-well plates in 20 μL of a...


US Patent US10399948 (2019)


BindingDB Entry DOI: 10.7270/Q2794726
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 3


(Rattus norvegicus (Rat))
BDBM417073
PNG
(4-(2-oxo-4-(2-phenoxyethoxy)pyridin-1(2H)-yl)benzo...)
Show SMILES O=c1cc(OCCOc2ccccc2)ccn1-c1ccc(cc1)C#N
Show InChI InChI=1S/C20H16N2O3/c21-15-16-6-8-17(9-7-16)22-11-10-19(14-20(22)23)25-13-12-24-18-4-2-1-3-5-18/h1-11,14H,12-13H2
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n/an/a 3.17E+3n/an/an/an/an/an/a



Vanderbilt University

US Patent


Assay Description
Gα15/TREx cells stably expressing rat mGlu3 were plated in black-walled, clear-bottomed, poly-D-lysine coated 384-well plates in 20 μL of a...


US Patent US10399948 (2019)


BindingDB Entry DOI: 10.7270/Q2794726
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 3


(Rattus norvegicus (Rat))
BDBM417085
PNG
(4-(2-(2,6-difluorophenoxy)ethoxy)-1-(4-fluoropheny...)
Show SMILES Fc1ccc(cc1)-n1ccc(OCCOc2c(F)cccc2F)cc1=O
Show InChI InChI=1S/C19H14F3NO3/c20-13-4-6-14(7-5-13)23-9-8-15(12-18(23)24)25-10-11-26-19-16(21)2-1-3-17(19)22/h1-9,12H,10-11H2
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n/an/a 3.18E+3n/an/an/an/an/an/a



Vanderbilt University

US Patent


Assay Description
Gα15/TREx cells stably expressing rat mGlu3 were plated in black-walled, clear-bottomed, poly-D-lysine coated 384-well plates in 20 μL of a...


US Patent US10399948 (2019)


BindingDB Entry DOI: 10.7270/Q2794726
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 3


(Rattus norvegicus (Rat))
BDBM417075
PNG
(2-oxo-4-(2-phenoxyethoxy)-2H-[1,3'-bipyridine]-5'-...)
Show SMILES O=c1cc(OCCOc2ccccc2)ccn1-c1cncc(c1)C#N
Show InChI InChI=1S/C19H15N3O3/c20-12-15-10-16(14-21-13-15)22-7-6-18(11-19(22)23)25-9-8-24-17-4-2-1-3-5-17/h1-7,10-11,13-14H,8-9H2
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n/an/a 3.41E+3n/an/an/an/an/an/a



Vanderbilt University

US Patent


Assay Description
Gα15/TREx cells stably expressing rat mGlu3 were plated in black-walled, clear-bottomed, poly-D-lysine coated 384-well plates in 20 μL of a...


US Patent US10399948 (2019)


BindingDB Entry DOI: 10.7270/Q2794726
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(Rattus norvegicus (Rat))
BDBM50278641
PNG
(CHEMBL4174935 | US10399948, Compound 14)
Show SMILES Fc1cccc(c1)-n1ccc(OCCOc2ccccc2)nc1=O
Show InChI InChI=1S/C18H15FN2O3/c19-14-5-4-6-15(13-14)21-10-9-17(20-18(21)22)24-12-11-23-16-7-2-1-3-8-16/h1-10,13H,11-12H2
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n/an/a 3.54E+3n/an/an/an/an/an/a



Vanderbilt University

US Patent


Assay Description
HEK 293A cells stably expressing rat mGlu5 were plated in black-walled, clear-bottomed, poly-D-lysine coated 384-well plates in 20 μL of assay m...


US Patent US10399948 (2019)


BindingDB Entry DOI: 10.7270/Q2794726
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 3


(Rattus norvegicus (Rat))
BDBM417078
PNG
(2-(4-Fluorophenyl)-5-(2-phenoxyethoxy)pyridazin-3(...)
Show SMILES Fc1ccc(cc1)-n1ncc(OCCOc2ccccc2)cc1=O
Show InChI InChI=1S/C18H15FN2O3/c19-14-6-8-15(9-7-14)21-18(22)12-17(13-20-21)24-11-10-23-16-4-2-1-3-5-16/h1-9,12-13H,10-11H2
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n/an/a 3.87E+3n/an/an/an/an/an/a



Vanderbilt University

US Patent


Assay Description
Gα15/TREx cells stably expressing rat mGlu3 were plated in black-walled, clear-bottomed, poly-D-lysine coated 384-well plates in 20 μL of a...


US Patent US10399948 (2019)


BindingDB Entry DOI: 10.7270/Q2794726
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 3


(Rattus norvegicus (Rat))
BDBM417051
PNG
(1-(4-fluorophenyl)-4-(2-(phenylthio)ethoxy)pyridin...)
Show SMILES Fc1ccc(cc1)-n1ccc(OCCSc2ccccc2)cc1=O
Show InChI InChI=1S/C19H16FNO2S/c20-15-6-8-16(9-7-15)21-11-10-17(14-19(21)22)23-12-13-24-18-4-2-1-3-5-18/h1-11,14H,12-13H2
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n/an/a 3.89E+3n/an/an/an/an/an/a



Vanderbilt University

US Patent


Assay Description
Gα15/TREx cells stably expressing rat mGlu3 were plated in black-walled, clear-bottomed, poly-D-lysine coated 384-well plates in 20 μL of a...


US Patent US10399948 (2019)


BindingDB Entry DOI: 10.7270/Q2794726
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 3


(Rattus norvegicus (Rat))
BDBM417058
PNG
(1-(2-Fluorophenyl)-4-(2-phenoxyethoxy)pyridin-2-on...)
Show SMILES Fc1ccccc1-n1ccc(OCCOc2ccccc2)cc1=O
Show InChI InChI=1S/C19H16FNO3/c20-17-8-4-5-9-18(17)21-11-10-16(14-19(21)22)24-13-12-23-15-6-2-1-3-7-15/h1-11,14H,12-13H2
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n/an/a 3.93E+3n/an/an/an/an/an/a



Vanderbilt University

US Patent


Assay Description
Gα15/TREx cells stably expressing rat mGlu3 were plated in black-walled, clear-bottomed, poly-D-lysine coated 384-well plates in 20 μL of a...


US Patent US10399948 (2019)


BindingDB Entry DOI: 10.7270/Q2794726
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 3


(Rattus norvegicus (Rat))
BDBM417052
PNG
(1-(4-fluorophenyl)-4-(2-(methyl(phenyl)amino)ethox...)
Show SMILES CN(CCOc1ccn(-c2ccc(F)cc2)c(=O)c1)c1ccccc1
Show InChI InChI=1S/C20H19FN2O2/c1-22(17-5-3-2-4-6-17)13-14-25-19-11-12-23(20(24)15-19)18-9-7-16(21)8-10-18/h2-12,15H,13-14H2,1H3
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n/an/a 4.00E+3n/an/an/an/an/an/a



Vanderbilt University

US Patent


Assay Description
Gα15/TREx cells stably expressing rat mGlu3 were plated in black-walled, clear-bottomed, poly-D-lysine coated 384-well plates in 20 μL of a...


US Patent US10399948 (2019)


BindingDB Entry DOI: 10.7270/Q2794726
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 3


(Rattus norvegicus (Rat))
BDBM417107
PNG
(4-(2-((6-chloropyridin-2-yl)oxy)ethoxy)-1-(4-fluor...)
Show SMILES Fc1ccc(cc1)-n1ccc(OCCOc2cccc(Cl)n2)cc1=O
Show InChI InChI=1S/C18H14ClFN2O3/c19-16-2-1-3-17(21-16)25-11-10-24-15-8-9-22(18(23)12-15)14-6-4-13(20)5-7-14/h1-9,12H,10-11H2
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n/an/a 4.27E+3n/an/an/an/an/an/a



Vanderbilt University

US Patent


Assay Description
Gα15/TREx cells stably expressing rat mGlu3 were plated in black-walled, clear-bottomed, poly-D-lysine coated 384-well plates in 20 μL of a...


US Patent US10399948 (2019)


BindingDB Entry DOI: 10.7270/Q2794726
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 3


(Rattus norvegicus (Rat))
BDBM417089
PNG
(1-(4-fluorophenyl)-4-(2-((2-fluoropyridin-3-yl)oxy...)
Show SMILES Fc1ccc(cc1)-n1ccc(OCCOc2cccnc2F)cc1=O
Show InChI InChI=1S/C18H14F2N2O3/c19-13-3-5-14(6-4-13)22-9-7-15(12-17(22)23)24-10-11-25-16-2-1-8-21-18(16)20/h1-9,12H,10-11H2
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n/an/a 4.74E+3n/an/an/an/an/an/a



Vanderbilt University

US Patent


Assay Description
Gα15/TREx cells stably expressing rat mGlu3 were plated in black-walled, clear-bottomed, poly-D-lysine coated 384-well plates in 20 μL of a...


US Patent US10399948 (2019)


BindingDB Entry DOI: 10.7270/Q2794726
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 3


(Rattus norvegicus (Rat))
BDBM417050
PNG
(1-(4-fluorophenyl)-4-(3-phenylpropoxy)pyridin-2(1H...)
Show SMILES Fc1ccc(cc1)-n1ccc(OCCCc2ccccc2)cc1=O
Show InChI InChI=1S/C20H18FNO2/c21-17-8-10-18(11-9-17)22-13-12-19(15-20(22)23)24-14-4-7-16-5-2-1-3-6-16/h1-3,5-6,8-13,15H,4,7,14H2
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n/an/a 5.41E+3n/an/an/an/an/an/a



Vanderbilt University

US Patent


Assay Description
Gα15/TREx cells stably expressing rat mGlu3 were plated in black-walled, clear-bottomed, poly-D-lysine coated 384-well plates in 20 μL of a...


US Patent US10399948 (2019)


BindingDB Entry DOI: 10.7270/Q2794726
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 3


(Rattus norvegicus (Rat))
BDBM417098
PNG
(4-(2-((2-chloropyridin-3-yl)oxy)ethoxy)-1-(4-fluor...)
Show SMILES Fc1ccc(cc1)-n1ccc(OCCOc2cccnc2Cl)cc1=O
Show InChI InChI=1S/C18H14ClFN2O3/c19-18-16(2-1-8-21-18)25-11-10-24-15-7-9-22(17(23)12-15)14-5-3-13(20)4-6-14/h1-9,12H,10-11H2
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n/an/a 5.56E+3n/an/an/an/an/an/a



Vanderbilt University

US Patent


Assay Description
Gα15/TREx cells stably expressing rat mGlu3 were plated in black-walled, clear-bottomed, poly-D-lysine coated 384-well plates in 20 μL of a...


US Patent US10399948 (2019)


BindingDB Entry DOI: 10.7270/Q2794726
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(Rattus norvegicus (Rat))
BDBM50278631
PNG
(CHEMBL4162785 | US10399948, Compound 22)
Show SMILES O=c1cc(OCCOc2ccccc2)ccn1-c1cccc(c1)C#N
Show InChI InChI=1S/C20H16N2O3/c21-15-16-5-4-6-17(13-16)22-10-9-19(14-20(22)23)25-12-11-24-18-7-2-1-3-8-18/h1-10,13-14H,11-12H2
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n/an/a 6.02E+3n/an/an/an/an/an/a



Vanderbilt University

US Patent


Assay Description
HEK 293A cells stably expressing rat mGlu5 were plated in black-walled, clear-bottomed, poly-D-lysine coated 384-well plates in 20 μL of assay m...


US Patent US10399948 (2019)


BindingDB Entry DOI: 10.7270/Q2794726
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 3


(Rattus norvegicus (Rat))
BDBM417074
PNG
(6'-fluoro-4-(2-phenoxyethoxy)-2H-[1,3'-bipyridin]-...)
Show SMILES Fc1ccc(cn1)-n1ccc(OCCOc2ccccc2)cc1=O
Show InChI InChI=1S/C18H15FN2O3/c19-17-7-6-14(13-20-17)21-9-8-16(12-18(21)22)24-11-10-23-15-4-2-1-3-5-15/h1-9,12-13H,10-11H2
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n/an/a 6.75E+3n/an/an/an/an/an/a



Vanderbilt University

US Patent


Assay Description
Gα15/TREx cells stably expressing rat mGlu3 were plated in black-walled, clear-bottomed, poly-D-lysine coated 384-well plates in 20 μL of a...


US Patent US10399948 (2019)


BindingDB Entry DOI: 10.7270/Q2794726
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(Rattus norvegicus (Rat))
BDBM417082
PNG
(4-(2-(2,3-difluorophenoxy)ethoxy)-1-(4-fluoropheny...)
Show SMILES Fc1ccc(cc1)-n1ccc(OCCOc2cccc(F)c2F)cc1=O
Show InChI InChI=1S/C19H14F3NO3/c20-13-4-6-14(7-5-13)23-9-8-15(12-18(23)24)25-10-11-26-17-3-1-2-16(21)19(17)22/h1-9,12H,10-11H2
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n/an/a 6.85E+3n/an/an/an/an/an/a



Vanderbilt University

US Patent


Assay Description
HEK 293A cells stably expressing rat mGlu5 were plated in black-walled, clear-bottomed, poly-D-lysine coated 384-well plates in 20 μL of assay m...


US Patent US10399948 (2019)


BindingDB Entry DOI: 10.7270/Q2794726
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(Rattus norvegicus (Rat))
BDBM50278640
PNG
(CHEMBL4160819 | US10399948, Compound 54)
Show SMILES Fc1ccc(cc1)-n1ccc(OCCOc2ncccc2Cl)cc1=O
Show InChI InChI=1S/C18H14ClFN2O3/c19-16-2-1-8-21-18(16)25-11-10-24-15-7-9-22(17(23)12-15)14-5-3-13(20)4-6-14/h1-9,12H,10-11H2
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n/an/a 7.82E+3n/an/an/an/an/an/a



Vanderbilt University

US Patent


Assay Description
HEK 293A cells stably expressing rat mGlu5 were plated in black-walled, clear-bottomed, poly-D-lysine coated 384-well plates in 20 μL of assay m...


US Patent US10399948 (2019)


BindingDB Entry DOI: 10.7270/Q2794726
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(Rattus norvegicus (Rat))
BDBM50278661
PNG
(CHEMBL4174878 | US10399948, Compound 49)
Show SMILES Fc1ccc(cc1)-n1ccc(OCCOc2cc(Cl)ccn2)cc1=O
Show InChI InChI=1S/C18H14ClFN2O3/c19-13-5-7-21-17(11-13)25-10-9-24-16-6-8-22(18(23)12-16)15-3-1-14(20)2-4-15/h1-8,11-12H,9-10H2
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n/an/a 8.80E+3n/an/an/an/an/an/a



Vanderbilt University

US Patent


Assay Description
HEK 293A cells stably expressing rat mGlu5 were plated in black-walled, clear-bottomed, poly-D-lysine coated 384-well plates in 20 μL of assay m...


US Patent US10399948 (2019)


BindingDB Entry DOI: 10.7270/Q2794726
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(Rattus norvegicus (Rat))
BDBM417090
PNG
(3-(2-((1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridin...)
Show SMILES Fc1ccc(cc1)-n1ccc(OCCOc2cccc(c2)C#N)cc1=O
Show InChI InChI=1S/C20H15FN2O3/c21-16-4-6-17(7-5-16)23-9-8-19(13-20(23)24)26-11-10-25-18-3-1-2-15(12-18)14-22/h1-9,12-13H,10-11H2
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US Patent


Assay Description
HEK 293A cells stably expressing rat mGlu5 were plated in black-walled, clear-bottomed, poly-D-lysine coated 384-well plates in 20 μL of assay m...


US Patent US10399948 (2019)


BindingDB Entry DOI: 10.7270/Q2794726
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 3


(Rattus norvegicus (Rat))
BDBM417055
PNG
(4-(2-(cyclohexyloxy)ethoxy)-1-(4-fluorophenyl)pyri...)
Show SMILES Fc1ccc(cc1)-n1ccc(OCCOC2CCCCC2)cc1=O
Show InChI InChI=1S/C19H22FNO3/c20-15-6-8-16(9-7-15)21-11-10-18(14-19(21)22)24-13-12-23-17-4-2-1-3-5-17/h6-11,14,17H,1-5,12-13H2
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US Patent


Assay Description
Gα15/TREx cells stably expressing rat mGlu3 were plated in black-walled, clear-bottomed, poly-D-lysine coated 384-well plates in 20 μL of a...


US Patent US10399948 (2019)


BindingDB Entry DOI: 10.7270/Q2794726
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(Rattus norvegicus (Rat))
BDBM417113
PNG
(2-(2-((1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridin...)
Show SMILES Fc1ccc(cc1)-n1ccc(OCCOc2cc(ccn2)C#N)cc1=O
Show InChI InChI=1S/C19H14FN3O3/c20-15-1-3-16(4-2-15)23-8-6-17(12-19(23)24)25-9-10-26-18-11-14(13-21)5-7-22-18/h1-8,11-12H,9-10H2
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Assay Description
HEK 293A cells stably expressing rat mGlu5 were plated in black-walled, clear-bottomed, poly-D-lysine coated 384-well plates in 20 μL of assay m...


US Patent US10399948 (2019)


BindingDB Entry DOI: 10.7270/Q2794726
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(Rattus norvegicus (Rat))
BDBM417109
PNG
(4-(2-((5-chloropyridin-2-yl)oxy)ethoxy)-1-(4-fluor...)
Show SMILES Fc1ccc(cc1)-n1ccc(OCCOc2ccc(Cl)cn2)cc1=O
Show InChI InChI=1S/C18H14ClFN2O3/c19-13-1-6-17(21-12-13)25-10-9-24-16-7-8-22(18(23)11-16)15-4-2-14(20)3-5-15/h1-8,11-12H,9-10H2
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US Patent


Assay Description
HEK 293A cells stably expressing rat mGlu5 were plated in black-walled, clear-bottomed, poly-D-lysine coated 384-well plates in 20 μL of assay m...


US Patent US10399948 (2019)


BindingDB Entry DOI: 10.7270/Q2794726
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 3


(Rattus norvegicus (Rat))
BDBM417110
PNG
(2-(2-((1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridin...)
Show SMILES Fc1ccc(cc1)-n1ccc(OCCOc2ncccc2C#N)cc1=O
Show InChI InChI=1S/C19H14FN3O3/c20-15-3-5-16(6-4-15)23-9-7-17(12-18(23)24)25-10-11-26-19-14(13-21)2-1-8-22-19/h1-9,12H,10-11H2
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US Patent


Assay Description
Gα15/TREx cells stably expressing rat mGlu3 were plated in black-walled, clear-bottomed, poly-D-lysine coated 384-well plates in 20 μL of a...


US Patent US10399948 (2019)


BindingDB Entry DOI: 10.7270/Q2794726
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 3


(Rattus norvegicus (Rat))
BDBM417097
PNG
(4-(2-((4-chloropyridin-3-yl)oxy)ethoxy)-1-(4-fluor...)
Show SMILES Fc1ccc(cc1)-n1ccc(OCCOc2cnccc2Cl)cc1=O
Show InChI InChI=1S/C18H14ClFN2O3/c19-16-5-7-21-12-17(16)25-10-9-24-15-6-8-22(18(23)11-15)14-3-1-13(20)2-4-14/h1-8,11-12H,9-10H2
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US Patent


Assay Description
Gα15/TREx cells stably expressing rat mGlu3 were plated in black-walled, clear-bottomed, poly-D-lysine coated 384-well plates in 20 μL of a...


US Patent US10399948 (2019)


BindingDB Entry DOI: 10.7270/Q2794726
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 3


(Rattus norvegicus (Rat))
BDBM417115
PNG
(6-(2-((1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridin...)
Show SMILES Fc1ccc(cc1)-n1ccc(OCCOc2cccc(n2)C#N)cc1=O
Show InChI InChI=1S/C19H14FN3O3/c20-14-4-6-16(7-5-14)23-9-8-17(12-19(23)24)25-10-11-26-18-3-1-2-15(13-21)22-18/h1-9,12H,10-11H2
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US Patent


Assay Description
Gα15/TREx cells stably expressing rat mGlu3 were plated in black-walled, clear-bottomed, poly-D-lysine coated 384-well plates in 20 μL of a...


US Patent US10399948 (2019)


BindingDB Entry DOI: 10.7270/Q2794726
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(Rattus norvegicus (Rat))
BDBM417088
PNG
(4-(2-(4-chlorophenoxy)ethoxy)-1-(4-fluorophenyl)py...)
Show SMILES Fc1ccc(cc1)-n1ccc(OCCOc2ccc(Cl)cc2)cc1=O
Show InChI InChI=1S/C19H15ClFNO3/c20-14-1-7-17(8-2-14)24-11-12-25-18-9-10-22(19(23)13-18)16-5-3-15(21)4-6-16/h1-10,13H,11-12H2
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US Patent


Assay Description
HEK 293A cells stably expressing rat mGlu5 were plated in black-walled, clear-bottomed, poly-D-lysine coated 384-well plates in 20 μL of assay m...


US Patent US10399948 (2019)


BindingDB Entry DOI: 10.7270/Q2794726
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 3


(Rattus norvegicus (Rat))
BDBM417060
PNG
(6'-fluoro-4-(2-phenoxyethoxy)-2H-[1,2'-bipyridin]-...)
Show SMILES Fc1cccc(n1)-n1ccc(OCCOc2ccccc2)cc1=O
Show InChI InChI=1S/C18H15FN2O3/c19-16-7-4-8-17(20-16)21-10-9-15(13-18(21)22)24-12-11-23-14-5-2-1-3-6-14/h1-10,13H,11-12H2
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US Patent


Assay Description
Gα15/TREx cells stably expressing rat mGlu3 were plated in black-walled, clear-bottomed, poly-D-lysine coated 384-well plates in 20 μL of a...


US Patent US10399948 (2019)


BindingDB Entry DOI: 10.7270/Q2794726
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 3


(Rattus norvegicus (Rat))
BDBM417093
PNG
(1-(4-fluorophenyl)-4-(2-(pyridin-3-yloxy)ethoxy)py...)
Show SMILES Fc1ccc(cc1)-n1ccc(OCCOc2cccnc2)cc1=O
Show InChI InChI=1S/C18H15FN2O3/c19-14-3-5-15(6-4-14)21-9-7-16(12-18(21)22)23-10-11-24-17-2-1-8-20-13-17/h1-9,12-13H,10-11H2
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US Patent


Assay Description
Gα15/TREx cells stably expressing rat mGlu3 were plated in black-walled, clear-bottomed, poly-D-lysine coated 384-well plates in 20 μL of a...


US Patent US10399948 (2019)


BindingDB Entry DOI: 10.7270/Q2794726
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(Rattus norvegicus (Rat))
BDBM417094
PNG
(1-(4-fluorophenyl)-4-(2-((6-fluoropyridin-3-yl)oxy...)
Show SMILES Fc1ccc(cc1)-n1ccc(OCCOc2ccc(F)nc2)cc1=O
Show InChI InChI=1S/C18H14F2N2O3/c19-13-1-3-14(4-2-13)22-8-7-15(11-18(22)23)24-9-10-25-16-5-6-17(20)21-12-16/h1-8,11-12H,9-10H2
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Assay Description
HEK 293A cells stably expressing rat mGlu5 were plated in black-walled, clear-bottomed, poly-D-lysine coated 384-well plates in 20 μL of assay m...


US Patent US10399948 (2019)


BindingDB Entry DOI: 10.7270/Q2794726
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(Rattus norvegicus (Rat))
BDBM417053
PNG
(1-(4-fluorophenyl)-4-((1-phenoxypropan-2-yl)oxy)py...)
Show SMILES CC(COc1ccccc1)Oc1ccn(-c2ccc(F)cc2)c(=O)c1
Show InChI InChI=1S/C20H18FNO3/c1-15(14-24-18-5-3-2-4-6-18)25-19-11-12-22(20(23)13-19)17-9-7-16(21)8-10-17/h2-13,15H,14H2,1H3
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Assay Description
HEK 293A cells stably expressing rat mGlu5 were plated in black-walled, clear-bottomed, poly-D-lysine coated 384-well plates in 20 μL of assay m...


US Patent US10399948 (2019)


BindingDB Entry DOI: 10.7270/Q2794726
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 3


(Rattus norvegicus (Rat))
BDBM417064
PNG
(1-(5-fluoropyridin-2-yl)-4-(2-phenoxyethoxy)pyrimi...)
Show SMILES Fc1ccc(nc1)-n1ccc(OCCOc2ccccc2)nc1=O
Show InChI InChI=1S/C17H14FN3O3/c18-13-6-7-15(19-12-13)21-9-8-16(20-17(21)22)24-11-10-23-14-4-2-1-3-5-14/h1-9,12H,10-11H2
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US Patent


Assay Description
Gα15/TREx cells stably expressing rat mGlu3 were plated in black-walled, clear-bottomed, poly-D-lysine coated 384-well plates in 20 μL of a...


US Patent US10399948 (2019)


BindingDB Entry DOI: 10.7270/Q2794726
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 3


(Rattus norvegicus (Rat))
BDBM417092
PNG
(1-(4-fluorophenyl)-4-(2-(4-(methoxymethyl)phenoxy)...)
Show SMILES COCc1ccc(OCCOc2ccn(-c3ccc(F)cc3)c(=O)c2)cc1
Show InChI InChI=1S/C21H20FNO4/c1-25-15-16-2-8-19(9-3-16)26-12-13-27-20-10-11-23(21(24)14-20)18-6-4-17(22)5-7-18/h2-11,14H,12-13,15H2,1H3
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Vanderbilt University

US Patent


Assay Description
Gα15/TREx cells stably expressing rat mGlu3 were plated in black-walled, clear-bottomed, poly-D-lysine coated 384-well plates in 20 μL of a...


US Patent US10399948 (2019)


BindingDB Entry DOI: 10.7270/Q2794726
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 3


(Rattus norvegicus (Rat))
BDBM417034
PNG
(4-(2-(Benzyloxy)ethoxy)-1-(4-fluorophenyl)pyridin-...)
Show SMILES Fc1ccc(cc1)-n1ccc(OCCOCc2ccccc2)cc1=O
Show InChI InChI=1S/C20H18FNO3/c21-17-6-8-18(9-7-17)22-11-10-19(14-20(22)23)25-13-12-24-15-16-4-2-1-3-5-16/h1-11,14H,12-13,15H2
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Vanderbilt University

US Patent


Assay Description
Gα15/TREx cells stably expressing rat mGlu3 were plated in black-walled, clear-bottomed, poly-D-lysine coated 384-well plates in 20 μL of a...


US Patent US10399948 (2019)


BindingDB Entry DOI: 10.7270/Q2794726
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 3


(Rattus norvegicus (Rat))
BDBM417061
PNG
(4-(2-phenoxyethoxy)-2H-[1,4'-bipyridin]-2-one | US...)
Show SMILES O=c1cc(OCCOc2ccccc2)ccn1-c1ccncc1
Show InChI InChI=1S/C18H16N2O3/c21-18-14-17(8-11-20(18)15-6-9-19-10-7-15)23-13-12-22-16-4-2-1-3-5-16/h1-11,14H,12-13H2
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US Patent


Assay Description
Gα15/TREx cells stably expressing rat mGlu3 were plated in black-walled, clear-bottomed, poly-D-lysine coated 384-well plates in 20 μL of a...


US Patent US10399948 (2019)


BindingDB Entry DOI: 10.7270/Q2794726
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Rattus norvegicus)
BDBM417064
PNG
(1-(5-fluoropyridin-2-yl)-4-(2-phenoxyethoxy)pyrimi...)
Show SMILES Fc1ccc(nc1)-n1ccc(OCCOc2ccccc2)nc1=O
Show InChI InChI=1S/C17H14FN3O3/c18-13-6-7-15(19-12-13)21-9-8-16(20-17(21)22)24-11-10-23-14-4-2-1-3-5-14/h1-9,12H,10-11H2
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US Patent


Assay Description
Gα15 HEK293 cells stably expressing rat mGlu2 were plated in black-walled, clear-bottomed, poly-D-lysine coated 384-well plates in 20 μL of...


US Patent US10399948 (2019)


BindingDB Entry DOI: 10.7270/Q2794726
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Rattus norvegicus)
BDBM50278643
PNG
(CHEMBL4171110 | US10399948, Compound 19)
Show SMILES Fc1cccc(c1)-n1ccc(OCCOc2ccccc2)cc1=O
Show InChI InChI=1S/C19H16FNO3/c20-15-5-4-6-16(13-15)21-10-9-18(14-19(21)22)24-12-11-23-17-7-2-1-3-8-17/h1-10,13-14H,11-12H2
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Vanderbilt University

US Patent


Assay Description
Gα15 HEK293 cells stably expressing rat mGlu2 were plated in black-walled, clear-bottomed, poly-D-lysine coated 384-well plates in 20 μL of...


US Patent US10399948 (2019)


BindingDB Entry DOI: 10.7270/Q2794726
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Rattus norvegicus)
BDBM417081
PNG
(4-(2-(4-fluorophenoxy)ethoxy)-1-(4-fluorophenyl)py...)
Show SMILES Fc1ccc(OCCOc2ccn(-c3ccc(F)cc3)c(=O)c2)cc1
Show InChI InChI=1S/C19H15F2NO3/c20-14-1-5-16(6-2-14)22-10-9-18(13-19(22)23)25-12-11-24-17-7-3-15(21)4-8-17/h1-10,13H,11-12H2
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US Patent


Assay Description
Gα15 HEK293 cells stably expressing rat mGlu2 were plated in black-walled, clear-bottomed, poly-D-lysine coated 384-well plates in 20 μL of...


US Patent US10399948 (2019)


BindingDB Entry DOI: 10.7270/Q2794726
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Rattus norvegicus)
BDBM417085
PNG
(4-(2-(2,6-difluorophenoxy)ethoxy)-1-(4-fluoropheny...)
Show SMILES Fc1ccc(cc1)-n1ccc(OCCOc2c(F)cccc2F)cc1=O
Show InChI InChI=1S/C19H14F3NO3/c20-13-4-6-14(7-5-13)23-9-8-15(12-18(23)24)25-10-11-26-19-16(21)2-1-3-17(19)22/h1-9,12H,10-11H2
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US Patent


Assay Description
Gα15 HEK293 cells stably expressing rat mGlu2 were plated in black-walled, clear-bottomed, poly-D-lysine coated 384-well plates in 20 μL of...


US Patent US10399948 (2019)


BindingDB Entry DOI: 10.7270/Q2794726
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Rattus norvegicus)
BDBM417089
PNG
(1-(4-fluorophenyl)-4-(2-((2-fluoropyridin-3-yl)oxy...)
Show SMILES Fc1ccc(cc1)-n1ccc(OCCOc2cccnc2F)cc1=O
Show InChI InChI=1S/C18H14F2N2O3/c19-13-3-5-14(6-4-13)22-9-7-15(12-17(22)23)24-10-11-25-16-2-1-8-21-18(16)20/h1-9,12H,10-11H2
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US Patent


Assay Description
Gα15 HEK293 cells stably expressing rat mGlu2 were plated in black-walled, clear-bottomed, poly-D-lysine coated 384-well plates in 20 μL of...


US Patent US10399948 (2019)


BindingDB Entry DOI: 10.7270/Q2794726
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Rattus norvegicus)
BDBM417109
PNG
(4-(2-((5-chloropyridin-2-yl)oxy)ethoxy)-1-(4-fluor...)
Show SMILES Fc1ccc(cc1)-n1ccc(OCCOc2ccc(Cl)cn2)cc1=O
Show InChI InChI=1S/C18H14ClFN2O3/c19-13-1-6-17(21-12-13)25-10-9-24-16-7-8-22(18(23)11-16)15-4-2-14(20)3-5-15/h1-8,11-12H,9-10H2
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US Patent


Assay Description
Gα15 HEK293 cells stably expressing rat mGlu2 were plated in black-walled, clear-bottomed, poly-D-lysine coated 384-well plates in 20 μL of...


US Patent US10399948 (2019)


BindingDB Entry DOI: 10.7270/Q2794726
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 3


(Rattus norvegicus (Rat))
BDBM417057
PNG
(1-(4-fluorophenyl)-4-(2-(phenylsulfonyl)ethoxy)pyr...)
Show SMILES Fc1ccc(cc1)-n1ccc(OCCS(=O)(=O)c2ccccc2)cc1=O
Show InChI InChI=1S/C19H16FNO4S/c20-15-6-8-16(9-7-15)21-11-10-17(14-19(21)22)25-12-13-26(23,24)18-4-2-1-3-5-18/h1-11,14H,12-13H2
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US Patent


Assay Description
Gα15/TREx cells stably expressing rat mGlu3 were plated in black-walled, clear-bottomed, poly-D-lysine coated 384-well plates in 20 μL of a...


US Patent US10399948 (2019)


BindingDB Entry DOI: 10.7270/Q2794726
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Rattus norvegicus)
BDBM50278641
PNG
(CHEMBL4174935 | US10399948, Compound 14)
Show SMILES Fc1cccc(c1)-n1ccc(OCCOc2ccccc2)nc1=O
Show InChI InChI=1S/C18H15FN2O3/c19-14-5-4-6-15(13-14)21-10-9-17(20-18(21)22)24-12-11-23-16-7-2-1-3-8-16/h1-10,13H,11-12H2
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US Patent


Assay Description
Gα15 HEK293 cells stably expressing rat mGlu2 were plated in black-walled, clear-bottomed, poly-D-lysine coated 384-well plates in 20 μL of...


US Patent US10399948 (2019)


BindingDB Entry DOI: 10.7270/Q2794726
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Rattus norvegicus)
BDBM417091
PNG
(4-(2-((1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridin...)
Show SMILES Fc1ccc(cc1)-n1ccc(OCCOc2ccc(cc2)C#N)cc1=O
Show InChI InChI=1S/C20H15FN2O3/c21-16-3-5-17(6-4-16)23-10-9-19(13-20(23)24)26-12-11-25-18-7-1-15(14-22)2-8-18/h1-10,13H,11-12H2
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US Patent


Assay Description
Gα15 HEK293 cells stably expressing rat mGlu2 were plated in black-walled, clear-bottomed, poly-D-lysine coated 384-well plates in 20 μL of...


US Patent US10399948 (2019)


BindingDB Entry DOI: 10.7270/Q2794726
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Rattus norvegicus)
BDBM417094
PNG
(1-(4-fluorophenyl)-4-(2-((6-fluoropyridin-3-yl)oxy...)
Show SMILES Fc1ccc(cc1)-n1ccc(OCCOc2ccc(F)nc2)cc1=O
Show InChI InChI=1S/C18H14F2N2O3/c19-13-1-3-14(4-2-13)22-8-7-15(11-18(22)23)24-9-10-25-16-5-6-17(20)21-12-16/h1-8,11-12H,9-10H2
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US Patent


Assay Description
Gα15 HEK293 cells stably expressing rat mGlu2 were plated in black-walled, clear-bottomed, poly-D-lysine coated 384-well plates in 20 μL of...


US Patent US10399948 (2019)


BindingDB Entry DOI: 10.7270/Q2794726
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Rattus norvegicus)
BDBM50278642
PNG
(CHEMBL4164285 | US10399948, Compound 17)
Show SMILES Fc1ccc(cc1)-n1ccc(OCCOc2ccccc2)nc1=O
Show InChI InChI=1S/C18H15FN2O3/c19-14-6-8-15(9-7-14)21-11-10-17(20-18(21)22)24-13-12-23-16-4-2-1-3-5-16/h1-11H,12-13H2
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US Patent


Assay Description
Gα15 HEK293 cells stably expressing rat mGlu2 were plated in black-walled, clear-bottomed, poly-D-lysine coated 384-well plates in 20 μL of...


US Patent US10399948 (2019)


BindingDB Entry DOI: 10.7270/Q2794726
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Rattus norvegicus)
BDBM50278633
PNG
(CHEMBL4166631 | US10399948, Compound 18)
Show SMILES Fc1ccc(cc1)-n1ccc(OCCOc2ccccc2)cc1=O
Show InChI InChI=1S/C19H16FNO3/c20-15-6-8-16(9-7-15)21-11-10-18(14-19(21)22)24-13-12-23-17-4-2-1-3-5-17/h1-11,14H,12-13H2
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US Patent


Assay Description
Gα15 HEK293 cells stably expressing rat mGlu2 were plated in black-walled, clear-bottomed, poly-D-lysine coated 384-well plates in 20 μL of...


US Patent US10399948 (2019)


BindingDB Entry DOI: 10.7270/Q2794726
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Rattus norvegicus)
BDBM417073
PNG
(4-(2-oxo-4-(2-phenoxyethoxy)pyridin-1(2H)-yl)benzo...)
Show SMILES O=c1cc(OCCOc2ccccc2)ccn1-c1ccc(cc1)C#N
Show InChI InChI=1S/C20H16N2O3/c21-15-16-6-8-17(9-7-16)22-11-10-19(14-20(22)23)25-13-12-24-18-4-2-1-3-5-18/h1-11,14H,12-13H2
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Vanderbilt University

US Patent


Assay Description
Gα15 HEK293 cells stably expressing rat mGlu2 were plated in black-walled, clear-bottomed, poly-D-lysine coated 384-well plates in 20 μL of...


US Patent US10399948 (2019)


BindingDB Entry DOI: 10.7270/Q2794726
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Rattus norvegicus)
BDBM417079
PNG
(4-(2-(2-fluorophenoxy)ethoxy)-1-(4-fluorophenyl)py...)
Show SMILES Fc1ccc(cc1)-n1ccc(OCCOc2ccccc2F)cc1=O
Show InChI InChI=1S/C19H15F2NO3/c20-14-5-7-15(8-6-14)22-10-9-16(13-19(22)23)24-11-12-25-18-4-2-1-3-17(18)21/h1-10,13H,11-12H2
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Vanderbilt University

US Patent


Assay Description
Gα15 HEK293 cells stably expressing rat mGlu2 were plated in black-walled, clear-bottomed, poly-D-lysine coated 384-well plates in 20 μL of...


US Patent US10399948 (2019)


BindingDB Entry DOI: 10.7270/Q2794726
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Rattus norvegicus)
BDBM417083
PNG
(4-(2-(2,4-difluorophenoxy)ethoxy)-1-(4-fluoropheny...)
Show SMILES Fc1ccc(cc1)-n1ccc(OCCOc2ccc(F)cc2F)cc1=O
Show InChI InChI=1S/C19H14F3NO3/c20-13-1-4-15(5-2-13)23-8-7-16(12-19(23)24)25-9-10-26-18-6-3-14(21)11-17(18)22/h1-8,11-12H,9-10H2
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Vanderbilt University

US Patent


Assay Description
Gα15 HEK293 cells stably expressing rat mGlu2 were plated in black-walled, clear-bottomed, poly-D-lysine coated 384-well plates in 20 μL of...


US Patent US10399948 (2019)


BindingDB Entry DOI: 10.7270/Q2794726
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Rattus norvegicus)
BDBM417086
PNG
(4-(2-(2-chlorophenoxy)ethoxy)-1-(4-fluorophenyl)py...)
Show SMILES Fc1ccc(cc1)-n1ccc(OCCOc2ccccc2Cl)cc1=O
Show InChI InChI=1S/C19H15ClFNO3/c20-17-3-1-2-4-18(17)25-12-11-24-16-9-10-22(19(23)13-16)15-7-5-14(21)6-8-15/h1-10,13H,11-12H2
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Vanderbilt University

US Patent


Assay Description
Gα15 HEK293 cells stably expressing rat mGlu2 were plated in black-walled, clear-bottomed, poly-D-lysine coated 384-well plates in 20 μL of...


US Patent US10399948 (2019)


BindingDB Entry DOI: 10.7270/Q2794726
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Rattus norvegicus)
BDBM417093
PNG
(1-(4-fluorophenyl)-4-(2-(pyridin-3-yloxy)ethoxy)py...)
Show SMILES Fc1ccc(cc1)-n1ccc(OCCOc2cccnc2)cc1=O
Show InChI InChI=1S/C18H15FN2O3/c19-14-3-5-15(6-4-14)21-9-7-16(12-18(21)22)23-10-11-24-17-2-1-8-20-13-17/h1-9,12-13H,10-11H2
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US Patent


Assay Description
Gα15 HEK293 cells stably expressing rat mGlu2 were plated in black-walled, clear-bottomed, poly-D-lysine coated 384-well plates in 20 μL of...


US Patent US10399948 (2019)


BindingDB Entry DOI: 10.7270/Q2794726
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Rattus norvegicus)
BDBM417115
PNG
(6-(2-((1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridin...)
Show SMILES Fc1ccc(cc1)-n1ccc(OCCOc2cccc(n2)C#N)cc1=O
Show InChI InChI=1S/C19H14FN3O3/c20-14-4-6-16(7-5-14)23-9-8-17(12-19(23)24)25-10-11-26-18-3-1-2-15(13-21)22-18/h1-9,12H,10-11H2
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US Patent


Assay Description
Gα15 HEK293 cells stably expressing rat mGlu2 were plated in black-walled, clear-bottomed, poly-D-lysine coated 384-well plates in 20 μL of...


US Patent US10399948 (2019)


BindingDB Entry DOI: 10.7270/Q2794726
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Rattus norvegicus)
BDBM417052
PNG
(1-(4-fluorophenyl)-4-(2-(methyl(phenyl)amino)ethox...)
Show SMILES CN(CCOc1ccn(-c2ccc(F)cc2)c(=O)c1)c1ccccc1
Show InChI InChI=1S/C20H19FN2O2/c1-22(17-5-3-2-4-6-17)13-14-25-19-11-12-23(20(24)15-19)18-9-7-16(21)8-10-18/h2-12,15H,13-14H2,1H3
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Vanderbilt University

US Patent


Assay Description
Gα15 HEK293 cells stably expressing rat mGlu2 were plated in black-walled, clear-bottomed, poly-D-lysine coated 384-well plates in 20 μL of...


US Patent US10399948 (2019)


BindingDB Entry DOI: 10.7270/Q2794726
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 3


(Rattus norvegicus (Rat))
BDBM417056
PNG
(1-(4-fluorophenyl)-4-(2-(phenylsulfinyl)ethoxy)pyr...)
Show SMILES Fc1ccc(cc1)-n1ccc(OCCS(=O)c2ccccc2)cc1=O
Show InChI InChI=1S/C19H16FNO3S/c20-15-6-8-16(9-7-15)21-11-10-17(14-19(21)22)24-12-13-25(23)18-4-2-1-3-5-18/h1-11,14H,12-13H2
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Vanderbilt University

US Patent


Assay Description
Gα15/TREx cells stably expressing rat mGlu3 were plated in black-walled, clear-bottomed, poly-D-lysine coated 384-well plates in 20 μL of a...


US Patent US10399948 (2019)


BindingDB Entry DOI: 10.7270/Q2794726
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Rattus norvegicus)
BDBM417058
PNG
(1-(2-Fluorophenyl)-4-(2-phenoxyethoxy)pyridin-2-on...)
Show SMILES Fc1ccccc1-n1ccc(OCCOc2ccccc2)cc1=O
Show InChI InChI=1S/C19H16FNO3/c20-17-8-4-5-9-18(17)21-11-10-16(14-19(21)22)24-13-12-23-15-6-2-1-3-7-15/h1-11,14H,12-13H2
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US Patent


Assay Description
Gα15 HEK293 cells stably expressing rat mGlu2 were plated in black-walled, clear-bottomed, poly-D-lysine coated 384-well plates in 20 μL of...


US Patent US10399948 (2019)


BindingDB Entry DOI: 10.7270/Q2794726
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Rattus norvegicus)
BDBM417061
PNG
(4-(2-phenoxyethoxy)-2H-[1,4'-bipyridin]-2-one | US...)
Show SMILES O=c1cc(OCCOc2ccccc2)ccn1-c1ccncc1
Show InChI InChI=1S/C18H16N2O3/c21-18-14-17(8-11-20(18)15-6-9-19-10-7-15)23-13-12-22-16-4-2-1-3-5-16/h1-11,14H,12-13H2
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Vanderbilt University

US Patent


Assay Description
Gα15 HEK293 cells stably expressing rat mGlu2 were plated in black-walled, clear-bottomed, poly-D-lysine coated 384-well plates in 20 μL of...


US Patent US10399948 (2019)


BindingDB Entry DOI: 10.7270/Q2794726
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Rattus norvegicus)
BDBM417069
PNG
(1-(3,5-difluorophenyl)-4-(2-phenoxyethoxy)pyridin-...)
Show SMILES Fc1cc(F)cc(c1)-n1ccc(OCCOc2ccccc2)cc1=O
Show InChI InChI=1S/C19H15F2NO3/c20-14-10-15(21)12-16(11-14)22-7-6-18(13-19(22)23)25-9-8-24-17-4-2-1-3-5-17/h1-7,10-13H,8-9H2
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US Patent


Assay Description
Gα15 HEK293 cells stably expressing rat mGlu2 were plated in black-walled, clear-bottomed, poly-D-lysine coated 384-well plates in 20 μL of...


US Patent US10399948 (2019)


BindingDB Entry DOI: 10.7270/Q2794726
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Rattus norvegicus)
BDBM417078
PNG
(2-(4-Fluorophenyl)-5-(2-phenoxyethoxy)pyridazin-3(...)
Show SMILES Fc1ccc(cc1)-n1ncc(OCCOc2ccccc2)cc1=O
Show InChI InChI=1S/C18H15FN2O3/c19-14-6-8-15(9-7-14)21-18(22)12-17(13-20-21)24-11-10-23-16-4-2-1-3-5-16/h1-9,12-13H,10-11H2
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Vanderbilt University

US Patent


Assay Description
Gα15 HEK293 cells stably expressing rat mGlu2 were plated in black-walled, clear-bottomed, poly-D-lysine coated 384-well plates in 20 μL of...


US Patent US10399948 (2019)


BindingDB Entry DOI: 10.7270/Q2794726
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Rattus norvegicus)
BDBM50278655
PNG
(CHEMBL4171435 | US10399948, Compound 31)
Show SMILES Fc1ccc(cc1)-n1ccc(OCCOc2cccc(F)c2)cc1=O
Show InChI InChI=1S/C19H15F2NO3/c20-14-4-6-16(7-5-14)22-9-8-18(13-19(22)23)25-11-10-24-17-3-1-2-15(21)12-17/h1-9,12-13H,10-11H2
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Vanderbilt University

US Patent


Assay Description
Gα15 HEK293 cells stably expressing rat mGlu2 were plated in black-walled, clear-bottomed, poly-D-lysine coated 384-well plates in 20 μL of...


US Patent US10399948 (2019)


BindingDB Entry DOI: 10.7270/Q2794726
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Rattus norvegicus)
BDBM417088
PNG
(4-(2-(4-chlorophenoxy)ethoxy)-1-(4-fluorophenyl)py...)
Show SMILES Fc1ccc(cc1)-n1ccc(OCCOc2ccc(Cl)cc2)cc1=O
Show InChI InChI=1S/C19H15ClFNO3/c20-14-1-7-17(8-2-14)24-11-12-25-18-9-10-22(19(23)13-18)16-5-3-15(21)4-6-16/h1-10,13H,11-12H2
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US Patent


Assay Description
Gα15 HEK293 cells stably expressing rat mGlu2 were plated in black-walled, clear-bottomed, poly-D-lysine coated 384-well plates in 20 μL of...


US Patent US10399948 (2019)


BindingDB Entry DOI: 10.7270/Q2794726
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Rattus norvegicus)
BDBM417059
PNG
(4-(2-phenoxyethoxy)-2H-[1,2'-bipyridin]-2-one | US...)
Show SMILES O=c1cc(OCCOc2ccccc2)ccn1-c1ccccn1
Show InChI InChI=1S/C18H16N2O3/c21-18-14-16(9-11-20(18)17-8-4-5-10-19-17)23-13-12-22-15-6-2-1-3-7-15/h1-11,14H,12-13H2
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US Patent


Assay Description
Gα15 HEK293 cells stably expressing rat mGlu2 were plated in black-walled, clear-bottomed, poly-D-lysine coated 384-well plates in 20 μL of...


US Patent US10399948 (2019)


BindingDB Entry DOI: 10.7270/Q2794726
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Rattus norvegicus)
BDBM417076
PNG
(5'-fluoro-4-(2-phenoxyethoxy)-2H-[1,3'-bipyridin]-...)
Show SMILES Fc1cncc(c1)-n1ccc(OCCOc2ccccc2)cc1=O
Show InChI InChI=1S/C18H15FN2O3/c19-14-10-15(13-20-12-14)21-7-6-17(11-18(21)22)24-9-8-23-16-4-2-1-3-5-16/h1-7,10-13H,8-9H2
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US Patent


Assay Description
Gα15 HEK293 cells stably expressing rat mGlu2 were plated in black-walled, clear-bottomed, poly-D-lysine coated 384-well plates in 20 μL of...


US Patent US10399948 (2019)


BindingDB Entry DOI: 10.7270/Q2794726
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Rattus norvegicus)
BDBM417084
PNG
(4-(2-(2,5-difluorophenoxy)ethoxy)-1-(4-fluoropheny...)
Show SMILES Fc1ccc(cc1)-n1ccc(OCCOc2cc(F)ccc2F)cc1=O
Show InChI InChI=1S/C19H14F3NO3/c20-13-1-4-15(5-2-13)23-8-7-16(12-19(23)24)25-9-10-26-18-11-14(21)3-6-17(18)22/h1-8,11-12H,9-10H2
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US Patent


Assay Description
Gα15 HEK293 cells stably expressing rat mGlu2 were plated in black-walled, clear-bottomed, poly-D-lysine coated 384-well plates in 20 μL of...


US Patent US10399948 (2019)


BindingDB Entry DOI: 10.7270/Q2794726
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Rattus norvegicus)
BDBM417092
PNG
(1-(4-fluorophenyl)-4-(2-(4-(methoxymethyl)phenoxy)...)
Show SMILES COCc1ccc(OCCOc2ccn(-c3ccc(F)cc3)c(=O)c2)cc1
Show InChI InChI=1S/C21H20FNO4/c1-25-15-16-2-8-19(9-3-16)26-12-13-27-20-10-11-23(21(24)14-20)18-6-4-17(22)5-7-18/h2-11,14H,12-13,15H2,1H3
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US Patent


Assay Description
Gα15 HEK293 cells stably expressing rat mGlu2 were plated in black-walled, clear-bottomed, poly-D-lysine coated 384-well plates in 20 μL of...


US Patent US10399948 (2019)


BindingDB Entry DOI: 10.7270/Q2794726
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Rattus norvegicus)
BDBM417097
PNG
(4-(2-((4-chloropyridin-3-yl)oxy)ethoxy)-1-(4-fluor...)
Show SMILES Fc1ccc(cc1)-n1ccc(OCCOc2cnccc2Cl)cc1=O
Show InChI InChI=1S/C18H14ClFN2O3/c19-16-5-7-21-12-17(16)25-10-9-24-15-6-8-22(18(23)11-15)14-3-1-13(20)2-4-14/h1-8,11-12H,9-10H2
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US Patent


Assay Description
Gα15 HEK293 cells stably expressing rat mGlu2 were plated in black-walled, clear-bottomed, poly-D-lysine coated 384-well plates in 20 μL of...


US Patent US10399948 (2019)


BindingDB Entry DOI: 10.7270/Q2794726
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Rattus norvegicus)
BDBM417107
PNG
(4-(2-((6-chloropyridin-2-yl)oxy)ethoxy)-1-(4-fluor...)
Show SMILES Fc1ccc(cc1)-n1ccc(OCCOc2cccc(Cl)n2)cc1=O
Show InChI InChI=1S/C18H14ClFN2O3/c19-16-2-1-3-17(21-16)25-11-10-24-15-8-9-22(18(23)12-15)14-6-4-13(20)5-7-14/h1-9,12H,10-11H2
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US Patent


Assay Description
Gα15 HEK293 cells stably expressing rat mGlu2 were plated in black-walled, clear-bottomed, poly-D-lysine coated 384-well plates in 20 μL of...


US Patent US10399948 (2019)


BindingDB Entry DOI: 10.7270/Q2794726
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Rattus norvegicus)
BDBM50278640
PNG
(CHEMBL4160819 | US10399948, Compound 54)
Show SMILES Fc1ccc(cc1)-n1ccc(OCCOc2ncccc2Cl)cc1=O
Show InChI InChI=1S/C18H14ClFN2O3/c19-16-2-1-8-21-18(16)25-11-10-24-15-7-9-22(17(23)12-15)14-5-3-13(20)4-6-14/h1-9,12H,10-11H2
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US Patent


Assay Description
Gα15 HEK293 cells stably expressing rat mGlu2 were plated in black-walled, clear-bottomed, poly-D-lysine coated 384-well plates in 20 μL of...


US Patent US10399948 (2019)


BindingDB Entry DOI: 10.7270/Q2794726
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Rattus norvegicus)
BDBM50278632
PNG
(CHEMBL4164219 | US10399948, Compound 1)
Show SMILES CC(COc1ccn(-c2ccc(F)cc2)c(=O)c1)Oc1ccccc1
Show InChI InChI=1S/C20H18FNO3/c1-15(25-18-5-3-2-4-6-18)14-24-19-11-12-22(20(23)13-19)17-9-7-16(21)8-10-17/h2-13,15H,14H2,1H3
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US Patent


Assay Description
Gα15 HEK293 cells stably expressing rat mGlu2 were plated in black-walled, clear-bottomed, poly-D-lysine coated 384-well plates in 20 μL of...


US Patent US10399948 (2019)


BindingDB Entry DOI: 10.7270/Q2794726
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(Rattus norvegicus (Rat))
BDBM50278632
PNG
(CHEMBL4164219 | US10399948, Compound 1)
Show SMILES CC(COc1ccn(-c2ccc(F)cc2)c(=O)c1)Oc1ccccc1
Show InChI InChI=1S/C20H18FNO3/c1-15(25-18-5-3-2-4-6-18)14-24-19-11-12-22(20(23)13-19)17-9-7-16(21)8-10-17/h2-13,15H,14H2,1H3
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Vanderbilt University

US Patent


Assay Description
HEK 293A cells stably expressing rat mGlu5 were plated in black-walled, clear-bottomed, poly-D-lysine coated 384-well plates in 20 μL of assay m...


US Patent US10399948 (2019)


BindingDB Entry DOI: 10.7270/Q2794726
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Rattus norvegicus)
BDBM417050
PNG
(1-(4-fluorophenyl)-4-(3-phenylpropoxy)pyridin-2(1H...)
Show SMILES Fc1ccc(cc1)-n1ccc(OCCCc2ccccc2)cc1=O
Show InChI InChI=1S/C20H18FNO2/c21-17-8-10-18(11-9-17)22-13-12-19(15-20(22)23)24-14-4-7-16-5-2-1-3-6-16/h1-3,5-6,8-13,15H,4,7,14H2
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Vanderbilt University

US Patent


Assay Description
Gα15 HEK293 cells stably expressing rat mGlu2 were plated in black-walled, clear-bottomed, poly-D-lysine coated 384-well plates in 20 μL of...


US Patent US10399948 (2019)


BindingDB Entry DOI: 10.7270/Q2794726
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Rattus norvegicus)
BDBM417053
PNG
(1-(4-fluorophenyl)-4-((1-phenoxypropan-2-yl)oxy)py...)
Show SMILES CC(COc1ccccc1)Oc1ccn(-c2ccc(F)cc2)c(=O)c1
Show InChI InChI=1S/C20H18FNO3/c1-15(14-24-18-5-3-2-4-6-18)25-19-11-12-22(20(23)13-19)17-9-7-16(21)8-10-17/h2-13,15H,14H2,1H3
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Vanderbilt University

US Patent


Assay Description
Gα15 HEK293 cells stably expressing rat mGlu2 were plated in black-walled, clear-bottomed, poly-D-lysine coated 384-well plates in 20 μL of...


US Patent US10399948 (2019)


BindingDB Entry DOI: 10.7270/Q2794726
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Rattus norvegicus)
BDBM417087
PNG
(4-(2-(3-chlorophenoxy)ethoxy)-1-(4-fluorophenyl)py...)
Show SMILES Fc1ccc(cc1)-n1ccc(OCCOc2cccc(Cl)c2)cc1=O
Show InChI InChI=1S/C19H15ClFNO3/c20-14-2-1-3-17(12-14)24-10-11-25-18-8-9-22(19(23)13-18)16-6-4-15(21)5-7-16/h1-9,12-13H,10-11H2
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Vanderbilt University

US Patent


Assay Description
Gα15 HEK293 cells stably expressing rat mGlu2 were plated in black-walled, clear-bottomed, poly-D-lysine coated 384-well plates in 20 μL of...


US Patent US10399948 (2019)


BindingDB Entry DOI: 10.7270/Q2794726
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Rattus norvegicus)
BDBM417098
PNG
(4-(2-((2-chloropyridin-3-yl)oxy)ethoxy)-1-(4-fluor...)
Show SMILES Fc1ccc(cc1)-n1ccc(OCCOc2cccnc2Cl)cc1=O
Show InChI InChI=1S/C18H14ClFN2O3/c19-18-16(2-1-8-21-18)25-11-10-24-15-7-9-22(17(23)12-15)14-5-3-13(20)4-6-14/h1-9,12H,10-11H2
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Vanderbilt University

US Patent


Assay Description
Gα15 HEK293 cells stably expressing rat mGlu2 were plated in black-walled, clear-bottomed, poly-D-lysine coated 384-well plates in 20 μL of...


US Patent US10399948 (2019)


BindingDB Entry DOI: 10.7270/Q2794726
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Rattus norvegicus)
BDBM417110
PNG
(2-(2-((1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridin...)
Show SMILES Fc1ccc(cc1)-n1ccc(OCCOc2ncccc2C#N)cc1=O
Show InChI InChI=1S/C19H14FN3O3/c20-15-3-5-16(6-4-15)23-9-7-17(12-18(23)24)25-10-11-26-19-14(13-21)2-1-8-22-19/h1-9,12H,10-11H2
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Vanderbilt University

US Patent


Assay Description
Gα15 HEK293 cells stably expressing rat mGlu2 were plated in black-walled, clear-bottomed, poly-D-lysine coated 384-well plates in 20 μL of...


US Patent US10399948 (2019)


BindingDB Entry DOI: 10.7270/Q2794726
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Rattus norvegicus)
BDBM417060
PNG
(6'-fluoro-4-(2-phenoxyethoxy)-2H-[1,2'-bipyridin]-...)
Show SMILES Fc1cccc(n1)-n1ccc(OCCOc2ccccc2)cc1=O
Show InChI InChI=1S/C18H15FN2O3/c19-16-7-4-8-17(20-16)21-10-9-15(13-18(21)22)24-12-11-23-14-5-2-1-3-6-14/h1-10,13H,11-12H2
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Vanderbilt University

US Patent


Assay Description
Gα15 HEK293 cells stably expressing rat mGlu2 were plated in black-walled, clear-bottomed, poly-D-lysine coated 384-well plates in 20 μL of...


US Patent US10399948 (2019)


BindingDB Entry DOI: 10.7270/Q2794726
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Rattus norvegicus)
BDBM50278654
PNG
(CHEMBL4174544 | US10399948, Compound 15)
Show SMILES Fc1ccc(cc1F)-n1ccc(OCCOc2ccccc2)nc1=O
Show InChI InChI=1S/C18H14F2N2O3/c19-15-7-6-13(12-16(15)20)22-9-8-17(21-18(22)23)25-11-10-24-14-4-2-1-3-5-14/h1-9,12H,10-11H2
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n/an/a>3.00E+4n/an/an/an/an/an/a



Vanderbilt University

US Patent


Assay Description
Gα15 HEK293 cells stably expressing rat mGlu2 were plated in black-walled, clear-bottomed, poly-D-lysine coated 384-well plates in 20 μL of...


US Patent US10399948 (2019)


BindingDB Entry DOI: 10.7270/Q2794726
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Rattus norvegicus)
BDBM50278653
PNG
(CHEMBL4163186 | US10399948, Compound 20)
Show SMILES Fc1ccc(cc1F)-n1ccc(OCCOc2ccccc2)cc1=O
Show InChI InChI=1S/C19H15F2NO3/c20-17-7-6-14(12-18(17)21)22-9-8-16(13-19(22)23)25-11-10-24-15-4-2-1-3-5-15/h1-9,12-13H,10-11H2
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Vanderbilt University

US Patent


Assay Description
Gα15 HEK293 cells stably expressing rat mGlu2 were plated in black-walled, clear-bottomed, poly-D-lysine coated 384-well plates in 20 μL of...


US Patent US10399948 (2019)


BindingDB Entry DOI: 10.7270/Q2794726
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Rattus norvegicus)
BDBM50278631
PNG
(CHEMBL4162785 | US10399948, Compound 22)
Show SMILES O=c1cc(OCCOc2ccccc2)ccn1-c1cccc(c1)C#N
Show InChI InChI=1S/C20H16N2O3/c21-15-16-5-4-6-17(13-16)22-10-9-19(14-20(22)23)25-12-11-24-18-7-2-1-3-8-18/h1-10,13-14H,11-12H2
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Vanderbilt University

US Patent


Assay Description
Gα15 HEK293 cells stably expressing rat mGlu2 were plated in black-walled, clear-bottomed, poly-D-lysine coated 384-well plates in 20 μL of...


US Patent US10399948 (2019)


BindingDB Entry DOI: 10.7270/Q2794726
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Rattus norvegicus)
BDBM417082
PNG
(4-(2-(2,3-difluorophenoxy)ethoxy)-1-(4-fluoropheny...)
Show SMILES Fc1ccc(cc1)-n1ccc(OCCOc2cccc(F)c2F)cc1=O
Show InChI InChI=1S/C19H14F3NO3/c20-13-4-6-14(7-5-13)23-9-8-15(12-18(23)24)25-10-11-26-17-3-1-2-16(21)19(17)22/h1-9,12H,10-11H2
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Vanderbilt University

US Patent


Assay Description
Gα15 HEK293 cells stably expressing rat mGlu2 were plated in black-walled, clear-bottomed, poly-D-lysine coated 384-well plates in 20 μL of...


US Patent US10399948 (2019)


BindingDB Entry DOI: 10.7270/Q2794726
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Rattus norvegicus)
BDBM417090
PNG
(3-(2-((1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridin...)
Show SMILES Fc1ccc(cc1)-n1ccc(OCCOc2cccc(c2)C#N)cc1=O
Show InChI InChI=1S/C20H15FN2O3/c21-16-4-6-17(7-5-16)23-9-8-19(13-20(23)24)26-11-10-25-18-3-1-2-15(12-18)14-22/h1-9,12-13H,10-11H2
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Vanderbilt University

US Patent


Assay Description
Gα15 HEK293 cells stably expressing rat mGlu2 were plated in black-walled, clear-bottomed, poly-D-lysine coated 384-well plates in 20 μL of...


US Patent US10399948 (2019)


BindingDB Entry DOI: 10.7270/Q2794726
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Rattus norvegicus)
BDBM417096
PNG
(4-(2-((5-chloropyridin-3-yl)oxy)ethoxy)-1-(4-fluor...)
Show SMILES Fc1ccc(cc1)-n1ccc(OCCOc2cncc(Cl)c2)cc1=O
Show InChI InChI=1S/C18H14ClFN2O3/c19-13-9-17(12-21-11-13)25-8-7-24-16-5-6-22(18(23)10-16)15-3-1-14(20)2-4-15/h1-6,9-12H,7-8H2
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Vanderbilt University

US Patent


Assay Description
Gα15 HEK293 cells stably expressing rat mGlu2 were plated in black-walled, clear-bottomed, poly-D-lysine coated 384-well plates in 20 μL of...


US Patent US10399948 (2019)


BindingDB Entry DOI: 10.7270/Q2794726
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Rattus norvegicus)
BDBM50278661
PNG
(CHEMBL4174878 | US10399948, Compound 49)
Show SMILES Fc1ccc(cc1)-n1ccc(OCCOc2cc(Cl)ccn2)cc1=O
Show InChI InChI=1S/C18H14ClFN2O3/c19-13-5-7-21-17(11-13)25-10-9-24-16-6-8-22(18(23)12-16)15-3-1-14(20)2-4-15/h1-8,11-12H,9-10H2
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Vanderbilt University

US Patent


Assay Description
Gα15 HEK293 cells stably expressing rat mGlu2 were plated in black-walled, clear-bottomed, poly-D-lysine coated 384-well plates in 20 μL of...


US Patent US10399948 (2019)


BindingDB Entry DOI: 10.7270/Q2794726
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Rattus norvegicus)
BDBM417101
PNG
(1-(4-fluorophenyl)-4-(2-(pyridin-2-yloxy)ethoxy)py...)
Show SMILES Fc1ccc(cc1)-n1ccc(OCCOc2ccccn2)cc1=O
Show InChI InChI=1S/C18H15FN2O3/c19-14-4-6-15(7-5-14)21-10-8-16(13-18(21)22)23-11-12-24-17-3-1-2-9-20-17/h1-10,13H,11-12H2
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Vanderbilt University

US Patent


Assay Description
Gα15 HEK293 cells stably expressing rat mGlu2 were plated in black-walled, clear-bottomed, poly-D-lysine coated 384-well plates in 20 μL of...


US Patent US10399948 (2019)


BindingDB Entry DOI: 10.7270/Q2794726
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 3


(Rattus norvegicus (Rat))
BDBM417054
PNG
(4-(2-(cyclopentyloxy)ethoxy)-1-(4-fluorophenyl)pyr...)
Show SMILES Fc1ccc(cc1)-n1ccc(OCCOC2CCCC2)cc1=O
Show InChI InChI=1S/C18H20FNO3/c19-14-5-7-15(8-6-14)20-10-9-17(13-18(20)21)23-12-11-22-16-3-1-2-4-16/h5-10,13,16H,1-4,11-12H2
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Vanderbilt University

US Patent


Assay Description
Gα15/TREx cells stably expressing rat mGlu3 were plated in black-walled, clear-bottomed, poly-D-lysine coated 384-well plates in 20 μL of a...


US Patent US10399948 (2019)


BindingDB Entry DOI: 10.7270/Q2794726
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Rattus norvegicus)
BDBM50278634
PNG
(CHEMBL4173490 | US10399948, Compound 23)
Show SMILES Fc1cc(cc(c1)-n1ccc(OCCOc2ccccc2)cc1=O)C#N
Show InChI InChI=1S/C20H15FN2O3/c21-16-10-15(14-22)11-17(12-16)23-7-6-19(13-20(23)24)26-9-8-25-18-4-2-1-3-5-18/h1-7,10-13H,8-9H2
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Vanderbilt University

US Patent


Assay Description
Gα15 HEK293 cells stably expressing rat mGlu2 were plated in black-walled, clear-bottomed, poly-D-lysine coated 384-well plates in 20 μL of...


US Patent US10399948 (2019)


BindingDB Entry DOI: 10.7270/Q2794726
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Rattus norvegicus)
BDBM417074
PNG
(6'-fluoro-4-(2-phenoxyethoxy)-2H-[1,3'-bipyridin]-...)
Show SMILES Fc1ccc(cn1)-n1ccc(OCCOc2ccccc2)cc1=O
Show InChI InChI=1S/C18H15FN2O3/c19-17-7-6-14(13-20-17)21-9-8-16(12-18(21)22)24-11-10-23-15-4-2-1-3-5-15/h1-9,12-13H,10-11H2
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Vanderbilt University

US Patent


Assay Description
Gα15 HEK293 cells stably expressing rat mGlu2 were plated in black-walled, clear-bottomed, poly-D-lysine coated 384-well plates in 20 μL of...


US Patent US10399948 (2019)


BindingDB Entry DOI: 10.7270/Q2794726
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Rattus norvegicus)
BDBM417075
PNG
(2-oxo-4-(2-phenoxyethoxy)-2H-[1,3'-bipyridine]-5'-...)
Show SMILES O=c1cc(OCCOc2ccccc2)ccn1-c1cncc(c1)C#N
Show InChI InChI=1S/C19H15N3O3/c20-12-15-10-16(14-21-13-15)22-7-6-18(11-19(22)23)25-9-8-24-17-4-2-1-3-5-17/h1-7,10-11,13-14H,8-9H2
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Vanderbilt University

US Patent


Assay Description
Gα15 HEK293 cells stably expressing rat mGlu2 were plated in black-walled, clear-bottomed, poly-D-lysine coated 384-well plates in 20 μL of...


US Patent US10399948 (2019)


BindingDB Entry DOI: 10.7270/Q2794726
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Rattus norvegicus)
BDBM417077
PNG
(3-(4-Fluorophenyl)-6-(2-phenoxyethoxy)pyrimidin-4(...)
Show SMILES Fc1ccc(cc1)-n1cnc(OCCOc2ccccc2)cc1=O
Show InChI InChI=1S/C18H15FN2O3/c19-14-6-8-15(9-7-14)21-13-20-17(12-18(21)22)24-11-10-23-16-4-2-1-3-5-16/h1-9,12-13H,10-11H2
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US Patent


Assay Description
Gα15 HEK293 cells stably expressing rat mGlu2 were plated in black-walled, clear-bottomed, poly-D-lysine coated 384-well plates in 20 μL of...


US Patent US10399948 (2019)


BindingDB Entry DOI: 10.7270/Q2794726
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Rattus norvegicus)
BDBM417104
PNG
(1-(4-fluorophenyl)-4-(2-((3-fluoropyridin-2-yl)oxy...)
Show SMILES Fc1ccc(cc1)-n1ccc(OCCOc2ncccc2F)cc1=O
Show InChI InChI=1S/C18H14F2N2O3/c19-13-3-5-14(6-4-13)22-9-7-15(12-17(22)23)24-10-11-25-18-16(20)2-1-8-21-18/h1-9,12H,10-11H2
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US Patent


Assay Description
Gα15 HEK293 cells stably expressing rat mGlu2 were plated in black-walled, clear-bottomed, poly-D-lysine coated 384-well plates in 20 μL of...


US Patent US10399948 (2019)


BindingDB Entry DOI: 10.7270/Q2794726
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Rattus norvegicus)
BDBM417106
PNG
(1-(4-fluorophenyl)-4-(2-((5-fluoropyridin-2-yl)oxy...)
Show SMILES Fc1ccc(cc1)-n1ccc(OCCOc2ccc(F)cn2)cc1=O
Show InChI InChI=1S/C18H14F2N2O3/c19-13-1-4-15(5-2-13)22-8-7-16(11-18(22)23)24-9-10-25-17-6-3-14(20)12-21-17/h1-8,11-12H,9-10H2
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US Patent


Assay Description
Gα15 HEK293 cells stably expressing rat mGlu2 were plated in black-walled, clear-bottomed, poly-D-lysine coated 384-well plates in 20 μL of...


US Patent US10399948 (2019)


BindingDB Entry DOI: 10.7270/Q2794726
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Rattus norvegicus)
BDBM417113
PNG
(2-(2-((1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridin...)
Show SMILES Fc1ccc(cc1)-n1ccc(OCCOc2cc(ccn2)C#N)cc1=O
Show InChI InChI=1S/C19H14FN3O3/c20-15-1-3-16(4-2-15)23-8-6-17(12-19(23)24)25-9-10-26-18-11-14(13-21)5-7-22-18/h1-8,11-12H,9-10H2
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US Patent


Assay Description
Gα15 HEK293 cells stably expressing rat mGlu2 were plated in black-walled, clear-bottomed, poly-D-lysine coated 384-well plates in 20 μL of...


US Patent US10399948 (2019)


BindingDB Entry DOI: 10.7270/Q2794726
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Rattus norvegicus)
BDBM417114
PNG
(6-(2-((1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridin...)
Show SMILES Fc1ccc(cc1)-n1ccc(OCCOc2ccc(cn2)C#N)cc1=O
Show InChI InChI=1S/C19H14FN3O3/c20-15-2-4-16(5-3-15)23-8-7-17(11-19(23)24)25-9-10-26-18-6-1-14(12-21)13-22-18/h1-8,11,13H,9-10H2
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n/an/a>3.00E+4n/an/an/an/an/an/a



Vanderbilt University

US Patent


Assay Description
Gα15 HEK293 cells stably expressing rat mGlu2 were plated in black-walled, clear-bottomed, poly-D-lysine coated 384-well plates in 20 μL of...


US Patent US10399948 (2019)


BindingDB Entry DOI: 10.7270/Q2794726
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Rattus norvegicus)
BDBM417051
PNG
(1-(4-fluorophenyl)-4-(2-(phenylthio)ethoxy)pyridin...)
Show SMILES Fc1ccc(cc1)-n1ccc(OCCSc2ccccc2)cc1=O
Show InChI InChI=1S/C19H16FNO2S/c20-15-6-8-16(9-7-15)21-11-10-17(14-19(21)22)23-12-13-24-18-4-2-1-3-5-18/h1-11,14H,12-13H2
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n/an/a>3.00E+4n/an/an/an/an/an/a



Vanderbilt University

US Patent


Assay Description
Gα15 HEK293 cells stably expressing rat mGlu2 were plated in black-walled, clear-bottomed, poly-D-lysine coated 384-well plates in 20 μL of...


US Patent US10399948 (2019)


BindingDB Entry DOI: 10.7270/Q2794726
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 3


(Rattus norvegicus (Rat))
BDBM417059
PNG
(4-(2-phenoxyethoxy)-2H-[1,2'-bipyridin]-2-one | US...)
Show SMILES O=c1cc(OCCOc2ccccc2)ccn1-c1ccccn1
Show InChI InChI=1S/C18H16N2O3/c21-18-14-16(9-11-20(18)17-8-4-5-10-19-17)23-13-12-22-15-6-2-1-3-7-15/h1-11,14H,12-13H2
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UniProtKB/SwissProt

GoogleScholar
PC cid
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UniChem
US Patent
n/an/a>3.00E+4n/an/an/an/an/an/a



Vanderbilt University

US Patent


Assay Description
Gα15/TREx cells stably expressing rat mGlu3 were plated in black-walled, clear-bottomed, poly-D-lysine coated 384-well plates in 20 μL of a...


US Patent US10399948 (2019)


BindingDB Entry DOI: 10.7270/Q2794726
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%