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Patent code US10399967

Compile Data Set for Download or QSAR
Found 143 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Interleukin-2


(Homo sapiens (Human))
BDBM412467
PNG
(N-(5-(5-ethyl-2-(5-methylisoxazol-3- yl)thiazol-4-...)
Show SMILES CCc1sc(nc1-c1ccc(NC(=O)c2cncc(C)c2C)nc1)-c1cc(C)on1
Show InChI InChI=1S/C22H21N5O2S/c1-5-18-20(26-22(30-18)17-8-13(3)29-27-17)15-6-7-19(24-10-15)25-21(28)16-11-23-9-12(2)14(16)4/h6-11H,5H2,1-4H3,(H,24,25,28)
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n/an/a 8n/an/an/an/an/an/a



PRCL RESEARCH INC.

US Patent


Assay Description
Human peripheral blood mononuclear cells (PBMCs) are prepared from heparinized human blood by separation over a Ficoll density gradient.PBMCs are sti...


US Patent US10399967 (2019)


BindingDB Entry DOI: 10.7270/Q2Z89FRQ
More data for this
Ligand-Target Pair
Interleukin-2


(Homo sapiens (Human))
BDBM412475
PNG
(5-ethyl-N-(5-(5-ethyl-2-(5- methylisoxazol-3-yl)th...)
Show SMILES CCc1sc(nc1-c1ccc(NC(=O)c2cncc(CC)c2C)nc1)-c1cc(C)on1
Show InChI InChI=1S/C23H23N5O2S/c1-5-15-10-24-12-17(14(15)4)22(29)26-20-8-7-16(11-25-20)21-19(6-2)31-23(27-21)18-9-13(3)30-28-18/h7-12H,5-6H2,1-4H3,(H,25,26,29)
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n/an/a 8n/an/an/an/an/an/a



PRCL RESEARCH INC.

US Patent


Assay Description
Human peripheral blood mononuclear cells (PBMCs) are prepared from heparinized human blood by separation over a Ficoll density gradient.PBMCs are sti...


US Patent US10399967 (2019)


BindingDB Entry DOI: 10.7270/Q2Z89FRQ
More data for this
Ligand-Target Pair
Interleukin-2


(Homo sapiens (Human))
BDBM412443
PNG
(5-bromo-N-(5-(5-ethyl-2-(5- methylisoxazol-3-yl)th...)
Show SMILES CCc1sc(nc1-c1ccc(NC(=O)c2cncc(Br)c2C)nc1)-c1cc(C)on1
Show InChI InChI=1S/C21H18BrN5O2S/c1-4-17-19(26-21(30-17)16-7-11(2)29-27-16)13-5-6-18(24-8-13)25-20(28)14-9-23-10-15(22)12(14)3/h5-10H,4H2,1-3H3,(H,24,25,28)
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n/an/a 9n/an/an/an/an/an/a



PRCL RESEARCH INC.

US Patent


Assay Description
Human peripheral blood mononuclear cells (PBMCs) are prepared from heparinized human blood by separation over a Ficoll density gradient.PBMCs are sti...


US Patent US10399967 (2019)


BindingDB Entry DOI: 10.7270/Q2Z89FRQ
More data for this
Ligand-Target Pair
Interleukin-2


(Homo sapiens (Human))
BDBM412392
PNG
(5-fluoro-4-methyl-N-(5-(5-(1-methyl- 1H-pyrazol-4-...)
Show SMILES Cc1c(F)cncc1C(=O)Nc1cnc(cn1)-c1cc(ccc1OC(F)(F)F)-c1cnn(C)c1
Show InChI InChI=1S/C22H16F4N6O2/c1-12-16(7-27-8-17(12)23)21(33)31-20-10-28-18(9-29-20)15-5-13(14-6-30-32(2)11-14)3-4-19(15)34-22(24,25)26/h3-11H,1-2H3,(H,29,31,33)
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n/an/a 9n/an/an/an/an/an/a



PRCL RESEARCH INC.

US Patent


Assay Description
Human peripheral blood mononuclear cells (PBMCs) are prepared from heparinized human blood by separation over a Ficoll density gradient.PBMCs are sti...


US Patent US10399967 (2019)


BindingDB Entry DOI: 10.7270/Q2Z89FRQ
More data for this
Ligand-Target Pair
Interleukin-2


(Homo sapiens (Human))
BDBM412445
PNG
(N-(5-(2-chloro-5- cyclopropoxyphenyl)pyridin-2-yl)...)
Show SMILES Cc1ccncc1C(=O)Nc1ccc(cn1)-c1cc(OC2CC2)ccc1Cl
Show InChI InChI=1S/C21H18ClN3O2/c1-13-8-9-23-12-18(13)21(26)25-20-7-2-14(11-24-20)17-10-16(5-6-19(17)22)27-15-3-4-15/h2,5-12,15H,3-4H2,1H3,(H,24,25,26)
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n/an/a 9n/an/an/an/an/an/a



PRCL RESEARCH INC.

US Patent


Assay Description
Human peripheral blood mononuclear cells (PBMCs) are prepared from heparinized human blood by separation over a Ficoll density gradient.PBMCs are sti...


US Patent US10399967 (2019)


BindingDB Entry DOI: 10.7270/Q2Z89FRQ
More data for this
Ligand-Target Pair
Interleukin-2


(Homo sapiens (Human))
BDBM412442
PNG
(5-chloro-N-(5-(5-ethyl-2-(5- methylisoxazol-3-yl)t...)
Show SMILES CCc1sc(nc1-c1ccc(NC(=O)c2cncc(Cl)c2C)nc1)-c1cc(C)on1
Show InChI InChI=1S/C21H18ClN5O2S/c1-4-17-19(26-21(30-17)16-7-11(2)29-27-16)13-5-6-18(24-8-13)25-20(28)14-9-23-10-15(22)12(14)3/h5-10H,4H2,1-3H3,(H,24,25,28)
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n/an/a 10n/an/an/an/an/an/a



PRCL RESEARCH INC.

US Patent


Assay Description
Human peripheral blood mononuclear cells (PBMCs) are prepared from heparinized human blood by separation over a Ficoll density gradient.PBMCs are sti...


US Patent US10399967 (2019)


BindingDB Entry DOI: 10.7270/Q2Z89FRQ
More data for this
Ligand-Target Pair
Interleukin-2


(Homo sapiens (Human))
BDBM412479
PNG
(N-(5-(5-ethyl-2-(isoxazol-3- yl)thiazol-4-yl)pyrid...)
Show SMILES CCc1sc(nc1-c1ccc(NC(=O)c2cncc(F)c2C)nc1)-c1ccon1
Show InChI InChI=1S/C20H16FN5O2S/c1-3-16-18(25-20(29-16)15-6-7-28-26-15)12-4-5-17(23-8-12)24-19(27)13-9-22-10-14(21)11(13)2/h4-10H,3H2,1-2H3,(H,23,24,27)
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n/an/a 10n/an/an/an/an/an/a



PRCL RESEARCH INC.

US Patent


Assay Description
Human peripheral blood mononuclear cells (PBMCs) are prepared from heparinized human blood by separation over a Ficoll density gradient.PBMCs are sti...


US Patent US10399967 (2019)


BindingDB Entry DOI: 10.7270/Q2Z89FRQ
More data for this
Ligand-Target Pair
Interleukin-2


(Homo sapiens (Human))
BDBM412441
PNG
(N-(5-(2-chloro-5- cyclopropoxyphenyl)pyridin-2-yl)...)
Show SMILES Cc1c(F)cncc1C(=O)Nc1ccc(cn1)-c1cc(OC2CC2)ccc1Cl
Show InChI InChI=1S/C21H17ClFN3O2/c1-12-17(10-24-11-19(12)23)21(27)26-20-7-2-13(9-25-20)16-8-15(5-6-18(16)22)28-14-3-4-14/h2,5-11,14H,3-4H2,1H3,(H,25,26,27)
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n/an/a 10n/an/an/an/an/an/a



PRCL RESEARCH INC.

US Patent


Assay Description
Human peripheral blood mononuclear cells (PBMCs) are prepared from heparinized human blood by separation over a Ficoll density gradient.PBMCs are sti...


US Patent US10399967 (2019)


BindingDB Entry DOI: 10.7270/Q2Z89FRQ
More data for this
Ligand-Target Pair
Interleukin-2


(Homo sapiens (Human))
BDBM412476
PNG
(N-(5-(5-ethyl-2-(3-methylisoxazol-5- yl)thiazol-4-...)
Show SMILES CCc1sc(nc1-c1ccc(NC(=O)c2cncc(F)c2C)nc1)-c1cc(C)no1
Show InChI InChI=1S/C21H18FN5O2S/c1-4-17-19(26-21(30-17)16-7-11(2)27-29-16)13-5-6-18(24-8-13)25-20(28)14-9-23-10-15(22)12(14)3/h5-10H,4H2,1-3H3,(H,24,25,28)
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n/an/a 10n/an/an/an/an/an/a



PRCL RESEARCH INC.

US Patent


Assay Description
Human peripheral blood mononuclear cells (PBMCs) are prepared from heparinized human blood by separation over a Ficoll density gradient.PBMCs are sti...


US Patent US10399967 (2019)


BindingDB Entry DOI: 10.7270/Q2Z89FRQ
More data for this
Ligand-Target Pair
Interleukin-2


(Homo sapiens (Human))
BDBM412489
PNG
(N-(5-(2-chloro-5-(1-methyl-1H- pyrazol-4-yl)phenyl...)
Show SMILES Cc1c(cncc1C(=O)Nc1ccc(cn1)-c1cc(ccc1Cl)-c1cnn(C)c1)C#N
Show InChI InChI=1S/C23H17ClN6O/c1-14-17(8-25)9-26-12-20(14)23(31)29-22-6-4-16(10-27-22)19-7-15(3-5-21(19)24)18-11-28-30(2)13-18/h3-7,9-13H,1-2H3,(H,27,29,31)
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n/an/a 10n/an/an/an/an/an/a



PRCL RESEARCH INC.

US Patent


Assay Description
Human peripheral blood mononuclear cells (PBMCs) are prepared from heparinized human blood by separation over a Ficoll density gradient.PBMCs are sti...


US Patent US10399967 (2019)


BindingDB Entry DOI: 10.7270/Q2Z89FRQ
More data for this
Ligand-Target Pair
Interleukin-2


(Homo sapiens (Human))
BDBM412440
PNG
(N-(5-(5-ethyl-2-(5-methylisoxazol-3- yl)thiazol-4-...)
Show SMILES CCc1sc(nc1-c1ccc(NC(=O)c2cncc(F)c2C)nc1)-c1cc(C)on1
Show InChI InChI=1S/C21H18FN5O2S/c1-4-17-19(26-21(30-17)16-7-11(2)29-27-16)13-5-6-18(24-8-13)25-20(28)14-9-23-10-15(22)12(14)3/h5-10H,4H2,1-3H3,(H,24,25,28)
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n/an/a 11n/an/an/an/an/an/a



PRCL RESEARCH INC.

US Patent


Assay Description
Human peripheral blood mononuclear cells (PBMCs) are prepared from heparinized human blood by separation over a Ficoll density gradient.PBMCs are sti...


US Patent US10399967 (2019)


BindingDB Entry DOI: 10.7270/Q2Z89FRQ
More data for this
Ligand-Target Pair
Interleukin-2


(Homo sapiens (Human))
BDBM412447
PNG
(N-(5-(5-ethyl-2-(5-methylisoxazol-3- yl)thiazol-4-...)
Show SMILES CCc1sc(nc1-c1ccc(NC(=O)c2cnccc2C)nc1)-c1cc(C)on1
Show InChI InChI=1S/C21H19N5O2S/c1-4-17-19(25-21(29-17)16-9-13(3)28-26-16)14-5-6-18(23-10-14)24-20(27)15-11-22-8-7-12(15)2/h5-11H,4H2,1-3H3,(H,23,24,27)
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n/an/a 11n/an/an/an/an/an/a



PRCL RESEARCH INC.

US Patent


Assay Description
Human peripheral blood mononuclear cells (PBMCs) are prepared from heparinized human blood by separation over a Ficoll density gradient.PBMCs are sti...


US Patent US10399967 (2019)


BindingDB Entry DOI: 10.7270/Q2Z89FRQ
More data for this
Ligand-Target Pair
Interleukin-2


(Homo sapiens (Human))
BDBM412451
PNG
(5-bromo-N-(5-(2-chloro-5- cyclopropoxyphenyl)pyraz...)
Show SMILES Cc1c(Br)cncc1C(=O)Nc1cnc(cn1)-c1cc(OC2CC2)ccc1Cl
Show InChI InChI=1S/C20H16BrClN4O2/c1-11-15(7-23-8-16(11)21)20(27)26-19-10-24-18(9-25-19)14-6-13(4-5-17(14)22)28-12-2-3-12/h4-10,12H,2-3H2,1H3,(H,25,26,27)
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n/an/a 11n/an/an/an/an/an/a



PRCL RESEARCH INC.

US Patent


Assay Description
Human peripheral blood mononuclear cells (PBMCs) are prepared from heparinized human blood by separation over a Ficoll density gradient.PBMCs are sti...


US Patent US10399967 (2019)


BindingDB Entry DOI: 10.7270/Q2Z89FRQ
More data for this
Ligand-Target Pair
Interleukin-2


(Homo sapiens (Human))
BDBM412468
PNG
(5-fluoro-4-methyl-N-(5-(5-methyl-2- (5-methylisoxa...)
Show SMILES Cc1cc(no1)-c1nc(c(C)s1)-c1ccc(NC(=O)c2cncc(F)c2C)nc1
Show InChI InChI=1S/C20H16FN5O2S/c1-10-6-16(26-28-10)20-25-18(12(3)29-20)13-4-5-17(23-7-13)24-19(27)14-8-22-9-15(21)11(14)2/h4-9H,1-3H3,(H,23,24,27)
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n/an/a 11n/an/an/an/an/an/a



PRCL RESEARCH INC.

US Patent


Assay Description
Human peripheral blood mononuclear cells (PBMCs) are prepared from heparinized human blood by separation over a Ficoll density gradient.PBMCs are sti...


US Patent US10399967 (2019)


BindingDB Entry DOI: 10.7270/Q2Z89FRQ
More data for this
Ligand-Target Pair
Interleukin-2


(Homo sapiens (Human))
BDBM412481
PNG
(5-chloro-N-(5-(2-chloro-5-(1-methyl- 1H-pyrazol-4-...)
Show SMILES Cc1c(Cl)cncc1C(=O)Nc1cnc(cn1)-c1cc(ccc1Cl)-c1cnn(C)c1
Show InChI InChI=1S/C21H16Cl2N6O/c1-12-16(7-24-8-18(12)23)21(30)28-20-10-25-19(9-26-20)15-5-13(3-4-17(15)22)14-6-27-29(2)11-14/h3-11H,1-2H3,(H,26,28,30)
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n/an/a 11n/an/an/an/an/an/a



PRCL RESEARCH INC.

US Patent


Assay Description
Human peripheral blood mononuclear cells (PBMCs) are prepared from heparinized human blood by separation over a Ficoll density gradient.PBMCs are sti...


US Patent US10399967 (2019)


BindingDB Entry DOI: 10.7270/Q2Z89FRQ
More data for this
Ligand-Target Pair
Interleukin-2


(Homo sapiens (Human))
BDBM412488
PNG
(5-bromo-N-(5-(2-chloro-5-(1-methyl- 1H-pyrazol-4-y...)
Show SMILES Cc1c(Br)cncc1C(=O)Nc1cnc(cn1)-c1cc(ccc1Cl)-c1cnn(C)c1
Show InChI InChI=1S/C21H16BrClN6O/c1-12-16(7-24-8-17(12)22)21(30)28-20-10-25-19(9-26-20)15-5-13(3-4-18(15)23)14-6-27-29(2)11-14/h3-11H,1-2H3,(H,26,28,30)
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n/an/a 11n/an/an/an/an/an/a



PRCL RESEARCH INC.

US Patent


Assay Description
Human peripheral blood mononuclear cells (PBMCs) are prepared from heparinized human blood by separation over a Ficoll density gradient.PBMCs are sti...


US Patent US10399967 (2019)


BindingDB Entry DOI: 10.7270/Q2Z89FRQ
More data for this
Ligand-Target Pair
Interleukin-2


(Homo sapiens (Human))
BDBM412432
PNG
(N-(5-(2-chloro-5- cyclopropoxyphenyl)pyrazin-2-yl)...)
Show SMILES Cc1ccncc1C(=O)Nc1cnc(cn1)-c1cc(OC2CC2)ccc1Cl
Show InChI InChI=1S/C20H17ClN4O2/c1-12-6-7-22-9-16(12)20(26)25-19-11-23-18(10-24-19)15-8-14(4-5-17(15)21)27-13-2-3-13/h4-11,13H,2-3H2,1H3,(H,24,25,26)
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n/an/a 12n/an/an/an/an/an/a



PRCL RESEARCH INC.

US Patent


Assay Description
Human peripheral blood mononuclear cells (PBMCs) are prepared from heparinized human blood by separation over a Ficoll density gradient.PBMCs are sti...


US Patent US10399967 (2019)


BindingDB Entry DOI: 10.7270/Q2Z89FRQ
More data for this
Ligand-Target Pair
Interleukin-2


(Homo sapiens (Human))
BDBM412377
PNG
(N-(5-(2-ethyl-5-(1-methyl-1H- pyrazol-4-yl)phenyl)...)
Show SMILES CCc1ccc(cc1-c1ccc(NC(=O)c2cnccc2C)nc1)-c1cnn(C)c1
Show InChI InChI=1S/C24H23N5O/c1-4-17-5-6-18(20-13-27-29(3)15-20)11-21(17)19-7-8-23(26-12-19)28-24(30)22-14-25-10-9-16(22)2/h5-15H,4H2,1-3H3,(H,26,28,30)
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n/an/a 12n/an/an/an/an/an/a



PRCL RESEARCH INC.

US Patent


Assay Description
Human peripheral blood mononuclear cells (PBMCs) are prepared from heparinized human blood by separation over a Ficoll density gradient.PBMCs are sti...


US Patent US10399967 (2019)


BindingDB Entry DOI: 10.7270/Q2Z89FRQ
More data for this
Ligand-Target Pair
Interleukin-2


(Homo sapiens (Human))
BDBM412387
PNG
(N-(2'-chloro-5'-(trifluoromethyl)- [1,1'-biphenyl]...)
Show SMILES Cc1ccncc1C(=O)Nc1ccc(cc1)-c1cc(ccc1Cl)C(F)(F)F
Show InChI InChI=1S/C20H14ClF3N2O/c1-12-8-9-25-11-17(12)19(27)26-15-5-2-13(3-6-15)16-10-14(20(22,23)24)4-7-18(16)21/h2-11H,1H3,(H,26,27)
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n/an/a 12n/an/an/an/an/an/a



PRCL RESEARCH INC.

US Patent


Assay Description
Human peripheral blood mononuclear cells (PBMCs) are prepared from heparinized human blood by separation over a Ficoll density gradient.PBMCs are sti...


US Patent US10399967 (2019)


BindingDB Entry DOI: 10.7270/Q2Z89FRQ
More data for this
Ligand-Target Pair
Interleukin-2


(Homo sapiens (Human))
BDBM412446
PNG
(5-cyano-N-(5-(5-ethyl-2-(5- methylisoxazol-3-yl)th...)
Show SMILES CCc1sc(nc1-c1ccc(NC(=O)c2cncc(C#N)c2C)nc1)-c1cc(C)on1
Show InChI InChI=1S/C22H18N6O2S/c1-4-18-20(27-22(31-18)17-7-12(2)30-28-17)14-5-6-19(25-10-14)26-21(29)16-11-24-9-15(8-23)13(16)3/h5-7,9-11H,4H2,1-3H3,(H,25,26,29)
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n/an/a 13n/an/an/an/an/an/a



PRCL RESEARCH INC.

US Patent


Assay Description
Human peripheral blood mononuclear cells (PBMCs) are prepared from heparinized human blood by separation over a Ficoll density gradient.PBMCs are sti...


US Patent US10399967 (2019)


BindingDB Entry DOI: 10.7270/Q2Z89FRQ
More data for this
Ligand-Target Pair
Interleukin-2


(Homo sapiens (Human))
BDBM412511
PNG
(N-(5-(2-chloro-5- isopropoxyphenyl)pyrazin-2-yl)-4...)
Show SMILES CC(C)Oc1ccc(Cl)c(c1)-c1cnc(NC(=O)c2cnccc2C)cn1
Show InChI InChI=1S/C20H19ClN4O2/c1-12(2)27-14-4-5-17(21)15(8-14)18-10-24-19(11-23-18)25-20(26)16-9-22-7-6-13(16)3/h4-12H,1-3H3,(H,24,25,26)
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n/an/a 13n/an/an/an/an/an/a



PRCL RESEARCH INC.

US Patent


Assay Description
Human peripheral blood mononuclear cells (PBMCs) are prepared from heparinized human blood by separation over a Ficoll density gradient.PBMCs are sti...


US Patent US10399967 (2019)


BindingDB Entry DOI: 10.7270/Q2Z89FRQ
More data for this
Ligand-Target Pair
Interleukin-2


(Homo sapiens (Human))
BDBM412384
PNG
(N-(5-(2-chloro-5-(5-methylthiazol-2- yl)phenyl)pyr...)
Show SMILES Cc1cnc(s1)-c1ccc(Cl)c(c1)-c1cnc(NC(=O)c2cnccc2C)cn1
Show InChI InChI=1S/C21H16ClN5OS/c1-12-5-6-23-9-16(12)20(28)27-19-11-24-18(10-25-19)15-7-14(3-4-17(15)22)21-26-8-13(2)29-21/h3-11H,1-2H3,(H,25,27,28)
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n/an/a 13n/an/an/an/an/an/a



PRCL RESEARCH INC.

US Patent


Assay Description
Human peripheral blood mononuclear cells (PBMCs) are prepared from heparinized human blood by separation over a Ficoll density gradient.PBMCs are sti...


US Patent US10399967 (2019)


BindingDB Entry DOI: 10.7270/Q2Z89FRQ
More data for this
Ligand-Target Pair
Interleukin-2


(Homo sapiens (Human))
BDBM412459
PNG
(N-(5-(2-chloro-5- isopropoxyphenyl)pyridin-2-yl)-4...)
Show SMILES CC(C)Oc1ccc(Cl)c(c1)-c1ccc(NC(=O)c2cnccc2C)nc1
Show InChI InChI=1S/C21H20ClN3O2/c1-13(2)27-16-5-6-19(22)17(10-16)15-4-7-20(24-11-15)25-21(26)18-12-23-9-8-14(18)3/h4-13H,1-3H3,(H,24,25,26)
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n/an/a 13n/an/an/an/an/an/a



PRCL RESEARCH INC.

US Patent


Assay Description
Human peripheral blood mononuclear cells (PBMCs) are prepared from heparinized human blood by separation over a Ficoll density gradient.PBMCs are sti...


US Patent US10399967 (2019)


BindingDB Entry DOI: 10.7270/Q2Z89FRQ
More data for this
Ligand-Target Pair
Interleukin-2


(Homo sapiens (Human))
BDBM412432
PNG
(N-(5-(2-chloro-5- cyclopropoxyphenyl)pyrazin-2-yl)...)
Show SMILES Cc1ccncc1C(=O)Nc1cnc(cn1)-c1cc(OC2CC2)ccc1Cl
Show InChI InChI=1S/C20H17ClN4O2/c1-12-6-7-22-9-16(12)20(26)25-19-11-23-18(10-24-19)15-8-14(4-5-17(15)21)27-13-2-3-13/h4-11,13H,2-3H2,1H3,(H,24,25,26)
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n/an/a 14n/an/an/an/an/an/a



PRCL RESEARCH INC.

US Patent


Assay Description
Human peripheral blood mononuclear cells (PBMCs) are prepared from heparinized human blood by separation over a Ficoll density gradient.PBMCs are sti...


US Patent US10399967 (2019)


BindingDB Entry DOI: 10.7270/Q2Z89FRQ
More data for this
Ligand-Target Pair
Interleukin-2


(Homo sapiens (Human))
BDBM412465
PNG
((Z)-N-(5-(1-(4-bromophenyl)prop-1- en-1-yl)pyridin...)
Show SMILES C\C=C(\c1ccc(Br)cc1)c1ccc(NC(=O)c2cncc(F)c2C)nc1
Show InChI InChI=1S/C21H17BrFN3O/c1-3-17(14-4-7-16(22)8-5-14)15-6-9-20(25-10-15)26-21(27)18-11-24-12-19(23)13(18)2/h3-12H,1-2H3,(H,25,26,27)/b17-3-
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n/an/a 14n/an/an/an/an/an/a



PRCL RESEARCH INC.

US Patent


Assay Description
Human peripheral blood mononuclear cells (PBMCs) are prepared from heparinized human blood by separation over a Ficoll density gradient.PBMCs are sti...


US Patent US10399967 (2019)


BindingDB Entry DOI: 10.7270/Q2Z89FRQ
More data for this
Ligand-Target Pair
Interleukin-2


(Homo sapiens (Human))
BDBM412482
PNG
(N-(5-(2-chloro-5-(1-methyl-1H- pyrazol-4-yl)phenyl...)
Show SMILES Cc1c(F)cncc1C(=O)Nc1ccc(cn1)-c1cc(ccc1Cl)-c1cnn(C)c1
Show InChI InChI=1S/C22H17ClFN5O/c1-13-18(10-25-11-20(13)24)22(30)28-21-6-4-15(8-26-21)17-7-14(3-5-19(17)23)16-9-27-29(2)12-16/h3-12H,1-2H3,(H,26,28,30)
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n/an/a 14n/an/an/an/an/an/a



PRCL RESEARCH INC.

US Patent


Assay Description
Human peripheral blood mononuclear cells (PBMCs) are prepared from heparinized human blood by separation over a Ficoll density gradient.PBMCs are sti...


US Patent US10399967 (2019)


BindingDB Entry DOI: 10.7270/Q2Z89FRQ
More data for this
Ligand-Target Pair
Interleukin-2


(Homo sapiens (Human))
BDBM412483
PNG
(5-bromo-N-(5-(2-chloro-5-(1-methyl- 1H-pyrazol-4-y...)
Show SMILES Cc1c(Br)cncc1C(=O)Nc1ccc(cn1)-c1cc(ccc1Cl)-c1cnn(C)c1
Show InChI InChI=1S/C22H17BrClN5O/c1-13-18(10-25-11-19(13)23)22(30)28-21-6-4-15(8-26-21)17-7-14(3-5-20(17)24)16-9-27-29(2)12-16/h3-12H,1-2H3,(H,26,28,30)
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n/an/a 14n/an/an/an/an/an/a



PRCL RESEARCH INC.

US Patent


Assay Description
Human peripheral blood mononuclear cells (PBMCs) are prepared from heparinized human blood by separation over a Ficoll density gradient.PBMCs are sti...


US Patent US10399967 (2019)


BindingDB Entry DOI: 10.7270/Q2Z89FRQ
More data for this
Ligand-Target Pair
Interleukin-2


(Homo sapiens (Human))
BDBM412472
PNG
((Z)-5-fluoro-N-(5-(1-(4- methoxyphenyl)prop-1-en-1...)
Show SMILES COc1ccc(cc1)C(=C\C)\c1ccc(NC(=O)c2cncc(F)c2C)nc1
Show InChI InChI=1S/C22H20FN3O2/c1-4-18(15-5-8-17(28-3)9-6-15)16-7-10-21(25-11-16)26-22(27)19-12-24-13-20(23)14(19)2/h4-13H,1-3H3,(H,25,26,27)/b18-4-
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n/an/a 16n/an/an/an/an/an/a



PRCL RESEARCH INC.

US Patent


Assay Description
Human peripheral blood mononuclear cells (PBMCs) are prepared from heparinized human blood by separation over a Ficoll density gradient.PBMCs are sti...


US Patent US10399967 (2019)


BindingDB Entry DOI: 10.7270/Q2Z89FRQ
More data for this
Ligand-Target Pair
Interleukin-2


(Homo sapiens (Human))
BDBM412504
PNG
(N-(5-(2-ethyl-5-((5-methylisoxazol-3- yl)oxy)pheny...)
Show SMILES CCc1ccc(Oc2cc(C)on2)cc1-c1cnc(NC(=O)c2cnccc2C)cn1
Show InChI InChI=1S/C23H21N5O3/c1-4-16-5-6-17(30-22-9-15(3)31-28-22)10-18(16)20-12-26-21(13-25-20)27-23(29)19-11-24-8-7-14(19)2/h5-13H,4H2,1-3H3,(H,26,27,29)
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n/an/a 17n/an/an/an/an/an/a



PRCL RESEARCH INC.

US Patent


Assay Description
Human peripheral blood mononuclear cells (PBMCs) are prepared from heparinized human blood by separation over a Ficoll density gradient.PBMCs are sti...


US Patent US10399967 (2019)


BindingDB Entry DOI: 10.7270/Q2Z89FRQ
More data for this
Ligand-Target Pair
Interleukin-2


(Homo sapiens (Human))
BDBM412490
PNG
(N-(5-(2-chloro-5-(1-methyl-1H- pyrazol-4-yl)phenyl...)
Show SMILES Cc1c(F)cncc1C(=O)Nc1cnc(cn1)-c1cc(ccc1Cl)-c1cnn(C)c1
Show InChI InChI=1S/C21H16ClFN6O/c1-12-16(7-24-8-18(12)23)21(30)28-20-10-25-19(9-26-20)15-5-13(3-4-17(15)22)14-6-27-29(2)11-14/h3-11H,1-2H3,(H,26,28,30)
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n/an/a 18n/an/an/an/an/an/a



PRCL RESEARCH INC.

US Patent


Assay Description
Human peripheral blood mononuclear cells (PBMCs) are prepared from heparinized human blood by separation over a Ficoll density gradient.PBMCs are sti...


US Patent US10399967 (2019)


BindingDB Entry DOI: 10.7270/Q2Z89FRQ
More data for this
Ligand-Target Pair
Interleukin-2


(Homo sapiens (Human))
BDBM412513
PNG
((Z)-N-(5-(1-(4-bromophenyl)prop-1- en-1-yl)pyrazin...)
Show SMILES C\C=C(\c1ccc(Br)cc1)c1cnc(NC(=O)c2cncc(F)c2C)cn1
Show InChI InChI=1S/C20H16BrFN4O/c1-3-15(13-4-6-14(21)7-5-13)18-10-25-19(11-24-18)26-20(27)16-8-23-9-17(22)12(16)2/h3-11H,1-2H3,(H,25,26,27)/b15-3-
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n/an/a 18n/an/an/an/an/an/a



PRCL RESEARCH INC.

US Patent


Assay Description
Human peripheral blood mononuclear cells (PBMCs) are prepared from heparinized human blood by separation over a Ficoll density gradient.PBMCs are sti...


US Patent US10399967 (2019)


BindingDB Entry DOI: 10.7270/Q2Z89FRQ
More data for this
Ligand-Target Pair
Interleukin-2


(Homo sapiens (Human))
BDBM412407
PNG
(N-(5-(2-chloro-5-(2-methyl-2H- tetrazol-5-yl)pheny...)
Show SMILES Cc1ccncc1C(=O)Nc1ccc(cn1)-c1cc(ccc1Cl)-c1nnn(C)n1
Show InChI InChI=1S/C20H16ClN7O/c1-12-7-8-22-11-16(12)20(29)24-18-6-4-14(10-23-18)15-9-13(3-5-17(15)21)19-25-27-28(2)26-19/h3-11H,1-2H3,(H,23,24,29)
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n/an/a 18n/an/an/an/an/an/a



PRCL RESEARCH INC.

US Patent


Assay Description
Human peripheral blood mononuclear cells (PBMCs) are prepared from heparinized human blood by separation over a Ficoll density gradient.PBMCs are sti...


US Patent US10399967 (2019)


BindingDB Entry DOI: 10.7270/Q2Z89FRQ
More data for this
Ligand-Target Pair
Interleukin-2


(Homo sapiens (Human))
BDBM412473
PNG
((Z)-methyl 4-(1-(6-(5-fluoro-4- methylnicotinamido...)
Show SMILES COC(=O)c1ccc(cc1)C(=C\C)\c1ccc(NC(=O)c2cncc(F)c2C)nc1
Show InChI InChI=1S/C23H20FN3O3/c1-4-18(15-5-7-16(8-6-15)23(29)30-3)17-9-10-21(26-11-17)27-22(28)19-12-25-13-20(24)14(19)2/h4-13H,1-3H3,(H,26,27,28)/b18-4-
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n/an/a 18n/an/an/an/an/an/a



PRCL RESEARCH INC.

US Patent


Assay Description
Human peripheral blood mononuclear cells (PBMCs) are prepared from heparinized human blood by separation over a Ficoll density gradient.PBMCs are sti...


US Patent US10399967 (2019)


BindingDB Entry DOI: 10.7270/Q2Z89FRQ
More data for this
Ligand-Target Pair
Interleukin-2


(Homo sapiens (Human))
BDBM412463
PNG
(N-(5-(5-ethyl-2-(5-methylisoxazol-3- yl)thiazol-4-...)
Show SMILES CCc1sc(nc1-c1ccc(NC(=O)c2cncc(c2C)[N+]([O-])=O)nc1)-c1cc(C)on1
Show InChI InChI=1S/C21H18N6O4S/c1-4-17-19(25-21(32-17)15-7-11(2)31-26-15)13-5-6-18(23-8-13)24-20(28)14-9-22-10-16(12(14)3)27(29)30/h5-10H,4H2,1-3H3,(H,23,24,28)
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n/an/a 18n/an/an/an/an/an/a



PRCL RESEARCH INC.

US Patent


Assay Description
Human peripheral blood mononuclear cells (PBMCs) are prepared from heparinized human blood by separation over a Ficoll density gradient.PBMCs are sti...


US Patent US10399967 (2019)


BindingDB Entry DOI: 10.7270/Q2Z89FRQ
More data for this
Ligand-Target Pair
Interleukin-2


(Homo sapiens (Human))
BDBM412394
PNG
(N-(5-(2-chloro-5-(3-fluoropyridin-4- yl)phenyl)pyr...)
Show SMILES Cc1ccncc1C(=O)Nc1cnc(cn1)-c1cc(ccc1Cl)-c1ccncc1F
Show InChI InChI=1S/C22H15ClFN5O/c1-13-4-6-25-9-17(13)22(30)29-21-12-27-20(11-28-21)16-8-14(2-3-18(16)23)15-5-7-26-10-19(15)24/h2-12H,1H3,(H,28,29,30)
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n/an/a 19n/an/an/an/an/an/a



PRCL RESEARCH INC.

US Patent


Assay Description
Human peripheral blood mononuclear cells (PBMCs) are prepared from heparinized human blood by separation over a Ficoll density gradient.PBMCs are sti...


US Patent US10399967 (2019)


BindingDB Entry DOI: 10.7270/Q2Z89FRQ
More data for this
Ligand-Target Pair
Interleukin-2


(Homo sapiens (Human))
BDBM412376
PNG
(5-fluoro-N-(5-(2-methoxy-5-(1- methyl-1H-pyrazol-4...)
Show SMILES COc1ccc(cc1-c1cnc(NC(=O)c2cncc(F)c2C)cn1)-c1cnn(C)c1
Show InChI InChI=1S/C22H19FN6O2/c1-13-17(8-24-9-18(13)23)22(30)28-21-11-25-19(10-26-21)16-6-14(4-5-20(16)31-3)15-7-27-29(2)12-15/h4-12H,1-3H3,(H,26,28,30)
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n/an/a 20n/an/an/an/an/an/a



PRCL RESEARCH INC.

US Patent


Assay Description
Human peripheral blood mononuclear cells (PBMCs) are prepared from heparinized human blood by separation over a Ficoll density gradient.PBMCs are sti...


US Patent US10399967 (2019)


BindingDB Entry DOI: 10.7270/Q2Z89FRQ
More data for this
Ligand-Target Pair
Interleukin-2


(Homo sapiens (Human))
BDBM412453
PNG
((Z)-N-(5-(1-(4-bromophenyl)prop-1- en-1-yl)pyrazin...)
Show SMILES C\C=C(\c1ccc(Br)cc1)c1cnc(NC(=O)c2cnccc2C)cn1
Show InChI InChI=1S/C20H17BrN4O/c1-3-16(14-4-6-15(21)7-5-14)18-11-24-19(12-23-18)25-20(26)17-10-22-9-8-13(17)2/h3-12H,1-2H3,(H,24,25,26)/b16-3-
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n/an/a 20n/an/an/an/an/an/a



PRCL RESEARCH INC.

US Patent


Assay Description
Human peripheral blood mononuclear cells (PBMCs) are prepared from heparinized human blood by separation over a Ficoll density gradient.PBMCs are sti...


US Patent US10399967 (2019)


BindingDB Entry DOI: 10.7270/Q2Z89FRQ
More data for this
Ligand-Target Pair
Interleukin-2


(Homo sapiens (Human))
BDBM412498
PNG
(N-(5-(2-chloro-5-(1-methyl-1H- pyrazol-4-yl)phenyl...)
Show SMILES CCc1cncc(C(=O)Nc2cnc(cn2)-c2cc(ccc2Cl)-c2cnn(C)c2)c1C
Show InChI InChI=1S/C23H21ClN6O/c1-4-15-8-25-10-19(14(15)2)23(31)29-22-12-26-21(11-27-22)18-7-16(5-6-20(18)24)17-9-28-30(3)13-17/h5-13H,4H2,1-3H3,(H,27,29,31)
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n/an/a 21n/an/an/an/an/an/a



PRCL RESEARCH INC.

US Patent


Assay Description
Human peripheral blood mononuclear cells (PBMCs) are prepared from heparinized human blood by separation over a Ficoll density gradient.PBMCs are sti...


US Patent US10399967 (2019)


BindingDB Entry DOI: 10.7270/Q2Z89FRQ
More data for this
Ligand-Target Pair
Interleukin-2


(Homo sapiens (Human))
BDBM412418
PNG
(N-(5-(2-ethyl-5-(2-methyl-2H- tetrazol-5-yl)phenyl...)
Show SMILES CCc1ccc(cc1-c1ccc(NC(=O)c2cnccc2C)nc1)-c1nnn(C)n1
Show InChI InChI=1S/C22H21N7O/c1-4-15-5-6-16(21-26-28-29(3)27-21)11-18(15)17-7-8-20(24-12-17)25-22(30)19-13-23-10-9-14(19)2/h5-13H,4H2,1-3H3,(H,24,25,30)
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n/an/a 22n/an/an/an/an/an/a



PRCL RESEARCH INC.

US Patent


Assay Description
Human peripheral blood mononuclear cells (PBMCs) are prepared from heparinized human blood by separation over a Ficoll density gradient.PBMCs are sti...


US Patent US10399967 (2019)


BindingDB Entry DOI: 10.7270/Q2Z89FRQ
More data for this
Ligand-Target Pair
Interleukin-2


(Homo sapiens (Human))
BDBM412423
PNG
(N-(5-(2-chloro-5-(1-methyl-1H- pyrazol-4-yl)phenyl...)
Show SMILES Cc1ccncc1C(=O)Nc1cnc(cn1)-c1cc(ccc1Cl)-c1cnn(C)c1
Show InChI InChI=1S/C21H17ClN6O/c1-13-5-6-23-9-17(13)21(29)27-20-11-24-19(10-25-20)16-7-14(3-4-18(16)22)15-8-26-28(2)12-15/h3-12H,1-2H3,(H,25,27,29)
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n/an/a 23n/an/an/an/an/an/a



PRCL RESEARCH INC.

US Patent


Assay Description
Human peripheral blood mononuclear cells (PBMCs) are prepared from heparinized human blood by separation over a Ficoll density gradient.PBMCs are sti...


US Patent US10399967 (2019)


BindingDB Entry DOI: 10.7270/Q2Z89FRQ
More data for this
Ligand-Target Pair
Interleukin-2


(Homo sapiens (Human))
BDBM412507
PNG
((E)-N-(5-(1-(6-ethoxypyridin-3- yl)prop-1-en-1-yl)...)
Show SMILES CCOc1ccc(cn1)C(=C\C)\c1ccc(NC(=O)c2cncc(F)c2C)nc1
Show InChI InChI=1S/C22H21FN4O2/c1-4-17(16-7-9-21(26-11-16)29-5-2)15-6-8-20(25-10-15)27-22(28)18-12-24-13-19(23)14(18)3/h4,6-13H,5H2,1-3H3,(H,25,27,28)/b17-4+
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n/an/a 25n/an/an/an/an/an/a



PRCL RESEARCH INC.

US Patent


Assay Description
Human peripheral blood mononuclear cells (PBMCs) are prepared from heparinized human blood by separation over a Ficoll density gradient.PBMCs are sti...


US Patent US10399967 (2019)


BindingDB Entry DOI: 10.7270/Q2Z89FRQ
More data for this
Ligand-Target Pair
Interleukin-2


(Homo sapiens (Human))
BDBM412378
PNG
(N-(5-(2-ethyl-5-(1-methyl-1H- pyrazol-4-yl)phenyl)...)
Show SMILES CCc1ccc(cc1-c1cnc(NC(=O)c2cnccc2C)cn1)-c1cnn(C)c1
Show InChI InChI=1S/C23H22N6O/c1-4-16-5-6-17(18-10-27-29(3)14-18)9-19(16)21-12-26-22(13-25-21)28-23(30)20-11-24-8-7-15(20)2/h5-14H,4H2,1-3H3,(H,26,28,30)
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n/an/a 25n/an/an/an/an/an/a



PRCL RESEARCH INC.

US Patent


Assay Description
Human peripheral blood mononuclear cells (PBMCs) are prepared from heparinized human blood by separation over a Ficoll density gradient.PBMCs are sti...


US Patent US10399967 (2019)


BindingDB Entry DOI: 10.7270/Q2Z89FRQ
More data for this
Ligand-Target Pair
Interleukin-2


(Homo sapiens (Human))
BDBM412397
PNG
(N-(5-(2-ethyl-5-(2-methyl-2H- tetrazol-5-yl)phenyl...)
Show SMILES CCc1ccc(cc1-c1cnc(NC(=O)c2cncc(F)c2C)cn1)-c1nnn(C)n1
Show InChI InChI=1S/C21H19FN8O/c1-4-13-5-6-14(20-27-29-30(3)28-20)7-15(13)18-10-25-19(11-24-18)26-21(31)16-8-23-9-17(22)12(16)2/h5-11H,4H2,1-3H3,(H,25,26,31)
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n/an/a 26n/an/an/an/an/an/a



PRCL RESEARCH INC.

US Patent


Assay Description
Human peripheral blood mononuclear cells (PBMCs) are prepared from heparinized human blood by separation over a Ficoll density gradient.PBMCs are sti...


US Patent US10399967 (2019)


BindingDB Entry DOI: 10.7270/Q2Z89FRQ
More data for this
Ligand-Target Pair
Interleukin-2


(Homo sapiens (Human))
BDBM412450
PNG
(N-(5-(2-chloro-5-(1,5-dimethyl-1H- pyrazol-4-yl)ph...)
Show SMILES Cc1c(cnn1C)-c1ccc(Cl)c(c1)-c1cnc(NC(=O)c2cnccc2C)cn1
Show InChI InChI=1S/C22H19ClN6O/c1-13-6-7-24-9-17(13)22(30)28-21-12-25-20(11-26-21)16-8-15(4-5-19(16)23)18-10-27-29(3)14(18)2/h4-12H,1-3H3,(H,26,28,30)
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n/an/a 26n/an/an/an/an/an/a



PRCL RESEARCH INC.

US Patent


Assay Description
Human peripheral blood mononuclear cells (PBMCs) are prepared from heparinized human blood by separation over a Ficoll density gradient.PBMCs are sti...


US Patent US10399967 (2019)


BindingDB Entry DOI: 10.7270/Q2Z89FRQ
More data for this
Ligand-Target Pair
Interleukin-2


(Homo sapiens (Human))
BDBM412396
PNG
(N-(5-(2-chloro-5-(2-methyl-2H- tetrazol-5-yl)pheny...)
Show SMILES Cc1c(F)cncc1C(=O)Nc1cnc(cn1)-c1cc(ccc1Cl)-c1nnn(C)n1
Show InChI InChI=1S/C19H14ClFN8O/c1-10-13(6-22-7-15(10)21)19(30)25-17-9-23-16(8-24-17)12-5-11(3-4-14(12)20)18-26-28-29(2)27-18/h3-9H,1-2H3,(H,24,25,30)
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n/an/a 26n/an/an/an/an/an/a



PRCL RESEARCH INC.

US Patent


Assay Description
Human peripheral blood mononuclear cells (PBMCs) are prepared from heparinized human blood by separation over a Ficoll density gradient.PBMCs are sti...


US Patent US10399967 (2019)


BindingDB Entry DOI: 10.7270/Q2Z89FRQ
More data for this
Ligand-Target Pair
Interleukin-2


(Homo sapiens (Human))
BDBM412404
PNG
(N-(5-(2-chloro-5-((6- (trifluoromethyl)pyridin-2- ...)
Show SMILES Cc1ccncc1C(=O)Nc1cnc(cn1)-c1cc(Oc2cccc(n2)C(F)(F)F)ccc1Cl
Show InChI InChI=1S/C23H15ClF3N5O2/c1-13-7-8-28-10-16(13)22(33)32-20-12-29-18(11-30-20)15-9-14(5-6-17(15)24)34-21-4-2-3-19(31-21)23(25,26)27/h2-12H,1H3,(H,30,32,33)
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n/an/a 26n/an/an/an/an/an/a



PRCL RESEARCH INC.

US Patent


Assay Description
Human peripheral blood mononuclear cells (PBMCs) are prepared from heparinized human blood by separation over a Ficoll density gradient.PBMCs are sti...


US Patent US10399967 (2019)


BindingDB Entry DOI: 10.7270/Q2Z89FRQ
More data for this
Ligand-Target Pair
Interleukin-2


(Homo sapiens (Human))
BDBM412427
PNG
(N-(5-(2-chloro-5-(2-methyl-2H- tetrazol-5-yl)pheny...)
Show SMILES Cc1ccncc1C(=O)Nc1cnc(cn1)-c1cc(ccc1Cl)-c1nnn(C)n1
Show InChI InChI=1S/C19H15ClN8O/c1-11-5-6-21-8-14(11)19(29)24-17-10-22-16(9-23-17)13-7-12(3-4-15(13)20)18-25-27-28(2)26-18/h3-10H,1-2H3,(H,23,24,29)
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n/an/a 28n/an/an/an/an/an/a



PRCL RESEARCH INC.

US Patent


Assay Description
Human peripheral blood mononuclear cells (PBMCs) are prepared from heparinized human blood by separation over a Ficoll density gradient.PBMCs are sti...


US Patent US10399967 (2019)


BindingDB Entry DOI: 10.7270/Q2Z89FRQ
More data for this
Ligand-Target Pair
Interleukin-2


(Homo sapiens (Human))
BDBM412379
PNG
(N-(5-(2-chloro-4- cyclopropoxyphenyl)pyridin-2-yl)...)
Show SMILES Cc1ccncc1C(=O)Nc1ccc(cn1)-c1ccc(OC2CC2)cc1Cl
Show InChI InChI=1S/C21H18ClN3O2/c1-13-8-9-23-12-18(13)21(26)25-20-7-2-14(11-24-20)17-6-5-16(10-19(17)22)27-15-3-4-15/h2,5-12,15H,3-4H2,1H3,(H,24,25,26)
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n/an/a 28n/an/an/an/an/an/a



PRCL RESEARCH INC.

US Patent


Assay Description
Human peripheral blood mononuclear cells (PBMCs) are prepared from heparinized human blood by separation over a Ficoll density gradient.PBMCs are sti...


US Patent US10399967 (2019)


BindingDB Entry DOI: 10.7270/Q2Z89FRQ
More data for this
Ligand-Target Pair
Interleukin-2


(Homo sapiens (Human))
BDBM412496
PNG
(N-(5-(2-chloro-5-(1-methyl-1H- pyrazol-4-yl)phenyl...)
Show SMILES Cc1cncc(C(=O)Nc2cnc(cn2)-c2cc(ccc2Cl)-c2cnn(C)c2)c1C
Show InChI InChI=1S/C22H19ClN6O/c1-13-7-24-9-18(14(13)2)22(30)28-21-11-25-20(10-26-21)17-6-15(4-5-19(17)23)16-8-27-29(3)12-16/h4-12H,1-3H3,(H,26,28,30)
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n/an/a 30n/an/an/an/an/an/a



PRCL RESEARCH INC.

US Patent


Assay Description
Human peripheral blood mononuclear cells (PBMCs) are prepared from heparinized human blood by separation over a Ficoll density gradient.PBMCs are sti...


US Patent US10399967 (2019)


BindingDB Entry DOI: 10.7270/Q2Z89FRQ
More data for this
Ligand-Target Pair
Interleukin-2


(Homo sapiens (Human))
BDBM412487
PNG
((Z)-5-fluoro-4-methyl-N-(5-(1-(4- (thiazol-2-yl)ph...)
Show SMILES C\C=C(\c1ccc(cc1)-c1nccs1)c1ccc(NC(=O)c2cncc(F)c2C)nc1
Show InChI InChI=1S/C24H19FN4OS/c1-3-19(16-4-6-17(7-5-16)24-27-10-11-31-24)18-8-9-22(28-12-18)29-23(30)20-13-26-14-21(25)15(20)2/h3-14H,1-2H3,(H,28,29,30)/b19-3-
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n/an/a 31n/an/an/an/an/an/a



PRCL RESEARCH INC.

US Patent


Assay Description
Human peripheral blood mononuclear cells (PBMCs) are prepared from heparinized human blood by separation over a Ficoll density gradient.PBMCs are sti...


US Patent US10399967 (2019)


BindingDB Entry DOI: 10.7270/Q2Z89FRQ
More data for this
Ligand-Target Pair
Interleukin-2


(Homo sapiens (Human))
BDBM412403
PNG
(4-methyl-N-(5-(2-methyl-5-(2- methyl-2H-tetrazol-5...)
Show SMILES Cc1ccncc1C(=O)Nc1ccc(cn1)-c1cc(ccc1C)-c1nnn(C)n1
Show InChI InChI=1S/C21H19N7O/c1-13-4-5-15(20-25-27-28(3)26-20)10-17(13)16-6-7-19(23-11-16)24-21(29)18-12-22-9-8-14(18)2/h4-12H,1-3H3,(H,23,24,29)
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n/an/a 31n/an/an/an/an/an/a



PRCL RESEARCH INC.

US Patent


Assay Description
Human peripheral blood mononuclear cells (PBMCs) are prepared from heparinized human blood by separation over a Ficoll density gradient.PBMCs are sti...


US Patent US10399967 (2019)


BindingDB Entry DOI: 10.7270/Q2Z89FRQ
More data for this
Ligand-Target Pair
Interleukin-2


(Homo sapiens (Human))
BDBM412426
PNG
(N-(5-(2-ethyl-5-(2-methyl-2H- tetrazol-5-yl)phenyl...)
Show SMILES CCc1ccc(cc1-c1cnc(NC(=O)c2cnccc2C)cn1)-c1nnn(C)n1
Show InChI InChI=1S/C21H20N8O/c1-4-14-5-6-15(20-26-28-29(3)27-20)9-16(14)18-11-24-19(12-23-18)25-21(30)17-10-22-8-7-13(17)2/h5-12H,4H2,1-3H3,(H,24,25,30)
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n/an/a 33n/an/an/an/an/an/a



PRCL RESEARCH INC.

US Patent


Assay Description
Human peripheral blood mononuclear cells (PBMCs) are prepared from heparinized human blood by separation over a Ficoll density gradient.PBMCs are sti...


US Patent US10399967 (2019)


BindingDB Entry DOI: 10.7270/Q2Z89FRQ
More data for this
Ligand-Target Pair
Interleukin-2


(Homo sapiens (Human))
BDBM412368
PNG
(N-(5-(2-chloro-5-(1H-pyrazol-4- yl)phenyl)pyrazin-...)
Show SMILES Cc1ccncc1C(=O)Nc1cnc(cn1)-c1cc(ccc1Cl)-c1cn[nH]c1
Show InChI InChI=1S/C20H15ClN6O/c1-12-4-5-22-9-16(12)20(28)27-19-11-23-18(10-24-19)15-6-13(2-3-17(15)21)14-7-25-26-8-14/h2-11H,1H3,(H,25,26)(H,24,27,28)
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n/an/a 34n/an/an/an/an/an/a



PRCL RESEARCH INC.

US Patent


Assay Description
Human peripheral blood mononuclear cells (PBMCs) are prepared from heparinized human blood by separation over a Ficoll density gradient.PBMCs are sti...


US Patent US10399967 (2019)


BindingDB Entry DOI: 10.7270/Q2Z89FRQ
More data for this
Ligand-Target Pair
Interleukin-2


(Homo sapiens (Human))
BDBM412510
PNG
(5-fluoro-N-(5-(5-((3-fluoropyridin-2- yl)oxy)-2-me...)
Show SMILES Cc1ccc(Oc2ncccc2F)cc1-c1cnc(NC(=O)c2cncc(F)c2C)cn1
Show InChI InChI=1S/C23H17F2N5O2/c1-13-5-6-15(32-23-18(24)4-3-7-27-23)8-16(13)20-11-29-21(12-28-20)30-22(31)17-9-26-10-19(25)14(17)2/h3-12H,1-2H3,(H,29,30,31)
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n/an/a 35n/an/an/an/an/an/a



PRCL RESEARCH INC.

US Patent


Assay Description
Human peripheral blood mononuclear cells (PBMCs) are prepared from heparinized human blood by separation over a Ficoll density gradient.PBMCs are sti...


US Patent US10399967 (2019)


BindingDB Entry DOI: 10.7270/Q2Z89FRQ
More data for this
Ligand-Target Pair
Interleukin-2


(Homo sapiens (Human))
BDBM412423
PNG
(N-(5-(2-chloro-5-(1-methyl-1H- pyrazol-4-yl)phenyl...)
Show SMILES Cc1ccncc1C(=O)Nc1cnc(cn1)-c1cc(ccc1Cl)-c1cnn(C)c1
Show InChI InChI=1S/C21H17ClN6O/c1-13-5-6-23-9-17(13)21(29)27-20-11-24-19(10-25-20)16-7-14(3-4-18(16)22)15-8-26-28(2)12-15/h3-12H,1-2H3,(H,25,27,29)
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n/an/a 38n/an/an/an/an/an/a



PRCL RESEARCH INC.

US Patent


Assay Description
Human peripheral blood mononuclear cells (PBMCs) are prepared from heparinized human blood by separation over a Ficoll density gradient.PBMCs are sti...


US Patent US10399967 (2019)


BindingDB Entry DOI: 10.7270/Q2Z89FRQ
More data for this
Ligand-Target Pair
Interleukin-2


(Homo sapiens (Human))
BDBM412461
PNG
(4-methyl-N-(5-(5-(2-methyl-2H- tetrazol-5-yl)-2- (...)
Show SMILES Cc1ccncc1C(=O)Nc1ccc(cn1)-c1cc(ccc1C(F)(F)F)-c1nnn(C)n1
Show InChI InChI=1S/C21H16F3N7O/c1-12-7-8-25-11-16(12)20(32)27-18-6-4-14(10-26-18)15-9-13(19-28-30-31(2)29-19)3-5-17(15)21(22,23)24/h3-11H,1-2H3,(H,26,27,32)
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n/an/a 40n/an/an/an/an/an/a



PRCL RESEARCH INC.

US Patent


Assay Description
Human peripheral blood mononuclear cells (PBMCs) are prepared from heparinized human blood by separation over a Ficoll density gradient.PBMCs are sti...


US Patent US10399967 (2019)


BindingDB Entry DOI: 10.7270/Q2Z89FRQ
More data for this
Ligand-Target Pair
Interleukin-2


(Homo sapiens (Human))
BDBM412424
PNG
(N-(5-(2-chloro-5-(pyridin-2- yloxy)phenyl)pyrazin-...)
Show SMILES Cc1c(F)cncc1C(=O)Nc1cnc(cn1)-c1cc(Oc2ccccn2)ccc1Cl
Show InChI InChI=1S/C22H15ClFN5O2/c1-13-16(9-25-10-18(13)24)22(30)29-20-12-27-19(11-28-20)15-8-14(5-6-17(15)23)31-21-4-2-3-7-26-21/h2-12H,1H3,(H,28,29,30)
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n/an/a 43n/an/an/an/an/an/a



PRCL RESEARCH INC.

US Patent


Assay Description
Human peripheral blood mononuclear cells (PBMCs) are prepared from heparinized human blood by separation over a Ficoll density gradient.PBMCs are sti...


US Patent US10399967 (2019)


BindingDB Entry DOI: 10.7270/Q2Z89FRQ
More data for this
Ligand-Target Pair
Interleukin-2


(Homo sapiens (Human))
BDBM412485
PNG
((E)-5-fluoro-N-(5-(1-(6- methoxypyridin-3-yl)prop-...)
Show SMILES COc1ccc(cn1)C(=C\C)\c1ccc(NC(=O)c2cncc(F)c2C)nc1
Show InChI InChI=1S/C21H19FN4O2/c1-4-16(15-6-8-20(28-3)25-10-15)14-5-7-19(24-9-14)26-21(27)17-11-23-12-18(22)13(17)2/h4-12H,1-3H3,(H,24,26,27)/b16-4+
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n/an/a 43n/an/an/an/an/an/a



PRCL RESEARCH INC.

US Patent


Assay Description
Human peripheral blood mononuclear cells (PBMCs) are prepared from heparinized human blood by separation over a Ficoll density gradient.PBMCs are sti...


US Patent US10399967 (2019)


BindingDB Entry DOI: 10.7270/Q2Z89FRQ
More data for this
Ligand-Target Pair
Interleukin-2


(Homo sapiens (Human))
BDBM412422
PNG
(4-methyl-N-(5-(2-methyl-5-(1- methyl-1H-pyrazol-4-...)
Show SMILES Cc1ccncc1C(=O)Nc1cnc(cn1)-c1cc(ccc1C)-c1cnn(C)c1
Show InChI InChI=1S/C22H20N6O/c1-14-4-5-16(17-9-26-28(3)13-17)8-18(14)20-11-25-21(12-24-20)27-22(29)19-10-23-7-6-15(19)2/h4-13H,1-3H3,(H,25,27,29)
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n/an/a 44n/an/an/an/an/an/a



PRCL RESEARCH INC.

US Patent


Assay Description
Human peripheral blood mononuclear cells (PBMCs) are prepared from heparinized human blood by separation over a Ficoll density gradient.PBMCs are sti...


US Patent US10399967 (2019)


BindingDB Entry DOI: 10.7270/Q2Z89FRQ
More data for this
Ligand-Target Pair
Interleukin-2


(Homo sapiens (Human))
BDBM412383
PNG
((Z)-5-fluoro-4-methyl-N-(5-(1-(4-(1- methyl-1H-imi...)
Show SMILES C\C=C(\c1ccc(cc1)-c1cncn1C)c1ccc(NC(=O)c2cncc(F)c2C)nc1
Show InChI InChI=1S/C25H22FN5O/c1-4-20(17-5-7-18(8-6-17)23-14-28-15-31(23)3)19-9-10-24(29-11-19)30-25(32)21-12-27-13-22(26)16(21)2/h4-15H,1-3H3,(H,29,30,32)/b20-4-
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n/an/a 44n/an/an/an/an/an/a



PRCL RESEARCH INC.

US Patent


Assay Description
Human peripheral blood mononuclear cells (PBMCs) are prepared from heparinized human blood by separation over a Ficoll density gradient.PBMCs are sti...


US Patent US10399967 (2019)


BindingDB Entry DOI: 10.7270/Q2Z89FRQ
More data for this
Ligand-Target Pair
Interleukin-2


(Homo sapiens (Human))
BDBM412419
PNG
(N-(5-(2-chloro-5-(pyridin-2- yloxy)phenyl)pyrazin-...)
Show SMILES Cc1ccncc1C(=O)Nc1cnc(cn1)-c1cc(Oc2ccccn2)ccc1Cl
Show InChI InChI=1S/C22H16ClN5O2/c1-14-7-9-24-11-17(14)22(29)28-20-13-26-19(12-27-20)16-10-15(5-6-18(16)23)30-21-4-2-3-8-25-21/h2-13H,1H3,(H,27,28,29)
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n/an/a 45n/an/an/an/an/an/a



PRCL RESEARCH INC.

US Patent


Assay Description
Human peripheral blood mononuclear cells (PBMCs) are prepared from heparinized human blood by separation over a Ficoll density gradient.PBMCs are sti...


US Patent US10399967 (2019)


BindingDB Entry DOI: 10.7270/Q2Z89FRQ
More data for this
Ligand-Target Pair
Interleukin-2


(Homo sapiens (Human))
BDBM412480
PNG
(4-methyl-N-(5-(2-methyl-5-(2- methyloxazol-4-yl)ph...)
Show SMILES Cc1nc(co1)-c1ccc(C)c(c1)-c1ccc(NC(=O)c2cnccc2C)nc1
Show InChI InChI=1S/C23H20N4O2/c1-14-4-5-17(21-13-29-16(3)26-21)10-19(14)18-6-7-22(25-11-18)27-23(28)20-12-24-9-8-15(20)2/h4-13H,1-3H3,(H,25,27,28)
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n/an/a 45n/an/an/an/an/an/a



PRCL RESEARCH INC.

US Patent


Assay Description
Human peripheral blood mononuclear cells (PBMCs) are prepared from heparinized human blood by separation over a Ficoll density gradient.PBMCs are sti...


US Patent US10399967 (2019)


BindingDB Entry DOI: 10.7270/Q2Z89FRQ
More data for this
Ligand-Target Pair
Interleukin-2


(Homo sapiens (Human))
BDBM412380
PNG
((Z)-N-(5-(1-(4-bromophenyl)prop-1- en-1-yl)pyridin...)
Show SMILES C\C=C(\c1ccc(Br)cc1)c1ccc(NC(=O)c2cnccc2C)nc1
Show InChI InChI=1S/C21H18BrN3O/c1-3-18(15-4-7-17(22)8-5-15)16-6-9-20(24-12-16)25-21(26)19-13-23-11-10-14(19)2/h3-13H,1-2H3,(H,24,25,26)/b18-3-
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n/an/a 46n/an/an/an/an/an/a



PRCL RESEARCH INC.

US Patent


Assay Description
Human peripheral blood mononuclear cells (PBMCs) are prepared from heparinized human blood by separation over a Ficoll density gradient.PBMCs are sti...


US Patent US10399967 (2019)


BindingDB Entry DOI: 10.7270/Q2Z89FRQ
More data for this
Ligand-Target Pair
Interleukin-2


(Homo sapiens (Human))
BDBM412386
PNG
(N-(5-(2-chloro-5-(pyrimidin-2- yloxy)phenyl)pyrazi...)
Show SMILES Cc1ccncc1C(=O)Nc1cnc(cn1)-c1cc(Oc2ncccn2)ccc1Cl
Show InChI InChI=1S/C21H15ClN6O2/c1-13-5-8-23-10-16(13)20(29)28-19-12-26-18(11-27-19)15-9-14(3-4-17(15)22)30-21-24-6-2-7-25-21/h2-12H,1H3,(H,27,28,29)
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n/an/a 46n/an/an/an/an/an/a



PRCL RESEARCH INC.

US Patent


Assay Description
Human peripheral blood mononuclear cells (PBMCs) are prepared from heparinized human blood by separation over a Ficoll density gradient.PBMCs are sti...


US Patent US10399967 (2019)


BindingDB Entry DOI: 10.7270/Q2Z89FRQ
More data for this
Ligand-Target Pair
Interleukin-2


(Homo sapiens (Human))
BDBM412393
PNG
(N-(5-(2-chloro-5-(pyrimidin-2- yloxy)phenyl)pyridi...)
Show SMILES Cc1c(F)cncc1C(=O)Nc1ccc(cn1)-c1cc(Oc2ncccn2)ccc1Cl
Show InChI InChI=1S/C22H15ClFN5O2/c1-13-17(11-25-12-19(13)24)21(30)29-20-6-3-14(10-28-20)16-9-15(4-5-18(16)23)31-22-26-7-2-8-27-22/h2-12H,1H3,(H,28,29,30)
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n/an/a 46n/an/an/an/an/an/a



PRCL RESEARCH INC.

US Patent


Assay Description
Human peripheral blood mononuclear cells (PBMCs) are prepared from heparinized human blood by separation over a Ficoll density gradient.PBMCs are sti...


US Patent US10399967 (2019)


BindingDB Entry DOI: 10.7270/Q2Z89FRQ
More data for this
Ligand-Target Pair
Interleukin-2


(Homo sapiens (Human))
BDBM412449
PNG
(N-(5-(5-cyclopropoxy-2- methylphenyl)pyrazin-2-yl)...)
Show SMILES Cc1ccc(OC2CC2)cc1-c1cnc(NC(=O)c2cncc(F)c2C)cn1
Show InChI InChI=1S/C21H19FN4O2/c1-12-3-4-15(28-14-5-6-14)7-16(12)19-10-25-20(11-24-19)26-21(27)17-8-23-9-18(22)13(17)2/h3-4,7-11,14H,5-6H2,1-2H3,(H,25,26,27)
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n/an/a 48n/an/an/an/an/an/a



PRCL RESEARCH INC.

US Patent


Assay Description
Human peripheral blood mononuclear cells (PBMCs) are prepared from heparinized human blood by separation over a Ficoll density gradient.PBMCs are sti...


US Patent US10399967 (2019)


BindingDB Entry DOI: 10.7270/Q2Z89FRQ
More data for this
Ligand-Target Pair
Interleukin-2


(Homo sapiens (Human))
BDBM412374
PNG
((Z)-N-(4-(1-(4-bromophenyl)prop-1- en-1-yl)-3-meth...)
Show SMILES C\C=C(\c1ccc(Br)cc1)c1ccc(NC(=O)c2cncc(F)c2C)cc1C
Show InChI InChI=1S/C23H20BrFN2O/c1-4-19(16-5-7-17(24)8-6-16)20-10-9-18(11-14(20)2)27-23(28)21-12-26-13-22(25)15(21)3/h4-13H,1-3H3,(H,27,28)/b19-4-
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n/an/a 50n/an/an/an/an/an/a



PRCL RESEARCH INC.

US Patent


Assay Description
Human peripheral blood mononuclear cells (PBMCs) are prepared from heparinized human blood by separation over a Ficoll density gradient.PBMCs are sti...


US Patent US10399967 (2019)


BindingDB Entry DOI: 10.7270/Q2Z89FRQ
More data for this
Ligand-Target Pair
Interleukin-2


(Homo sapiens (Human))
BDBM412421
PNG
(4-methyl-N-(5-(5-(pyridin-2-yloxy)- 2-(trifluorome...)
Show SMILES Cc1cnccc1C(=O)Nc1cnc(cn1)-c1cc(Oc2ccccn2)ccc1OC(F)(F)F
Show InChI InChI=1S/C23H16F3N5O3/c1-14-11-27-9-7-16(14)22(32)31-20-13-29-18(12-30-20)17-10-15(33-21-4-2-3-8-28-21)5-6-19(17)34-23(24,25)26/h2-13H,1H3,(H,30,31,32)
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n/an/a 50n/an/an/an/an/an/a



PRCL RESEARCH INC.

US Patent


Assay Description
Human peripheral blood mononuclear cells (PBMCs) are prepared from heparinized human blood by separation over a Ficoll density gradient.PBMCs are sti...


US Patent US10399967 (2019)


BindingDB Entry DOI: 10.7270/Q2Z89FRQ
More data for this
Ligand-Target Pair
Interleukin-2


(Homo sapiens (Human))
BDBM412466
PNG
(5-fluoro-N-(5-(1-(4-methoxyphenyl)- 2-methylprop-1...)
Show SMILES COc1ccc(cc1)C(=C(C)C)c1ccc(NC(=O)c2cncc(F)c2C)nc1
Show InChI InChI=1S/C23H22FN3O2/c1-14(2)22(16-5-8-18(29-4)9-6-16)17-7-10-21(26-11-17)27-23(28)19-12-25-13-20(24)15(19)3/h5-13H,1-4H3,(H,26,27,28)
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n/an/a 51n/an/an/an/an/an/a



PRCL RESEARCH INC.

US Patent


Assay Description
Human peripheral blood mononuclear cells (PBMCs) are prepared from heparinized human blood by separation over a Ficoll density gradient.PBMCs are sti...


US Patent US10399967 (2019)


BindingDB Entry DOI: 10.7270/Q2Z89FRQ
More data for this
Ligand-Target Pair
Interleukin-2


(Homo sapiens (Human))
BDBM412372
PNG
(N-(5-(2-ethoxy-5-(1-methyl-1H- pyrazol-4-yl)phenyl...)
Show SMILES CCOc1ccc(cc1-c1cnc(NC(=O)c2cnccc2C)cn1)-c1cnn(C)c1
Show InChI InChI=1S/C23H22N6O2/c1-4-31-21-6-5-16(17-10-27-29(3)14-17)9-18(21)20-12-26-22(13-25-20)28-23(30)19-11-24-8-7-15(19)2/h5-14H,4H2,1-3H3,(H,26,28,30)
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n/an/a 51n/an/an/an/an/an/a



PRCL RESEARCH INC.

US Patent


Assay Description
Human peripheral blood mononuclear cells (PBMCs) are prepared from heparinized human blood by separation over a Ficoll density gradient.PBMCs are sti...


US Patent US10399967 (2019)


BindingDB Entry DOI: 10.7270/Q2Z89FRQ
More data for this
Ligand-Target Pair
Interleukin-2


(Homo sapiens (Human))
BDBM412388
PNG
((Z)-5-fluoro-N-(5-((methoxyimino)(4- methoxyphenyl...)
Show SMILES CO\N=C(\c1ccc(OC)cc1)c1ccc(NC(=O)c2cncc(F)c2C)nc1
Show InChI InChI=1S/C21H19FN4O3/c1-13-17(11-23-12-18(13)22)21(27)25-19-9-6-15(10-24-19)20(26-29-3)14-4-7-16(28-2)8-5-14/h4-12H,1-3H3,(H,24,25,27)/b26-20-
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n/an/a 52n/an/an/an/an/an/a



PRCL RESEARCH INC.

US Patent


Assay Description
Human peripheral blood mononuclear cells (PBMCs) are prepared from heparinized human blood by separation over a Ficoll density gradient.PBMCs are sti...


US Patent US10399967 (2019)


BindingDB Entry DOI: 10.7270/Q2Z89FRQ
More data for this
Ligand-Target Pair
Interleukin-2


(Homo sapiens (Human))
BDBM412462
PNG
(4-chloro-3-(5-(4- methylnicotinamido)pyrazin-2- yl...)
Show SMILES Cc1ccncc1C(=O)Nc1cnc(cn1)-c1cc(OS(C)(=O)=O)ccc1Cl
Show InChI InChI=1S/C18H15ClN4O4S/c1-11-5-6-20-8-14(11)18(24)23-17-10-21-16(9-22-17)13-7-12(3-4-15(13)19)27-28(2,25)26/h3-10H,1-2H3,(H,22,23,24)
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n/an/a 57n/an/an/an/an/an/a



PRCL RESEARCH INC.

US Patent


Assay Description
Human peripheral blood mononuclear cells (PBMCs) are prepared from heparinized human blood by separation over a Ficoll density gradient.PBMCs are sti...


US Patent US10399967 (2019)


BindingDB Entry DOI: 10.7270/Q2Z89FRQ
More data for this
Ligand-Target Pair
Interleukin-2


(Homo sapiens (Human))
BDBM412381
PNG
((Z)-5-fluoro-4-methyl-N-(5-(1-(4-(4- methyl-1H-imi...)
Show SMILES C\C=C(\c1ccc(cc1)-n1cnc(C)c1)c1ccc(NC(=O)c2cncc(F)c2C)nc1
Show InChI InChI=1S/C25H22FN5O/c1-4-21(18-5-8-20(9-6-18)31-14-16(2)29-15-31)19-7-10-24(28-11-19)30-25(32)22-12-27-13-23(26)17(22)3/h4-15H,1-3H3,(H,28,30,32)/b21-4-
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n/an/a 58n/an/an/an/an/an/a



PRCL RESEARCH INC.

US Patent


Assay Description
Human peripheral blood mononuclear cells (PBMCs) are prepared from heparinized human blood by separation over a Ficoll density gradient.PBMCs are sti...


US Patent US10399967 (2019)


BindingDB Entry DOI: 10.7270/Q2Z89FRQ
More data for this
Ligand-Target Pair
Interleukin-2


(Homo sapiens (Human))
BDBM412506
PNG
(N-(5-(2-chloro-5- (isopropylamino)phenyl)pyridin-2...)
Show SMILES CC(C)Nc1ccc(Cl)c(c1)-c1ccc(NC(=O)c2cnccc2C)nc1
Show InChI InChI=1S/C21H21ClN4O/c1-13(2)25-16-5-6-19(22)17(10-16)15-4-7-20(24-11-15)26-21(27)18-12-23-9-8-14(18)3/h4-13,25H,1-3H3,(H,24,26,27)
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n/an/a 58n/an/an/an/an/an/a



PRCL RESEARCH INC.

US Patent


Assay Description
Human peripheral blood mononuclear cells (PBMCs) are prepared from heparinized human blood by separation over a Ficoll density gradient.PBMCs are sti...


US Patent US10399967 (2019)


BindingDB Entry DOI: 10.7270/Q2Z89FRQ
More data for this
Ligand-Target Pair
Interleukin-2


(Homo sapiens (Human))
BDBM412373
PNG
(N-(5-(2-chloro-5-(2-methylthiazol-4- yl)phenyl)pyr...)
Show SMILES Cc1nc(cs1)-c1ccc(Cl)c(c1)-c1cnc(NC(=O)c2cnccc2C)cn1
Show InChI InChI=1S/C21H16ClN5OS/c1-12-5-6-23-8-16(12)21(28)27-20-10-24-18(9-25-20)15-7-14(3-4-17(15)22)19-11-29-13(2)26-19/h3-11H,1-2H3,(H,25,27,28)
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n/an/a 60n/an/an/an/an/an/a



PRCL RESEARCH INC.

US Patent


Assay Description
Human peripheral blood mononuclear cells (PBMCs) are prepared from heparinized human blood by separation over a Ficoll density gradient.PBMCs are sti...


US Patent US10399967 (2019)


BindingDB Entry DOI: 10.7270/Q2Z89FRQ
More data for this
Ligand-Target Pair
Interleukin-2


(Homo sapiens (Human))
BDBM412455
PNG
(N-(5-(2-cyclopropoxy-5-(1-methyl- 1H-pyrazol-4-yl)...)
Show SMILES Cc1ccncc1C(=O)Nc1cnc(cn1)-c1cc(ccc1OC1CC1)-c1cnn(C)c1
Show InChI InChI=1S/C24H22N6O2/c1-15-7-8-25-11-20(15)24(31)29-23-13-26-21(12-27-23)19-9-16(17-10-28-30(2)14-17)3-6-22(19)32-18-4-5-18/h3,6-14,18H,4-5H2,1-2H3,(H,27,29,31)
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n/an/a 61n/an/an/an/an/an/a



PRCL RESEARCH INC.

US Patent


Assay Description
Human peripheral blood mononuclear cells (PBMCs) are prepared from heparinized human blood by separation over a Ficoll density gradient.PBMCs are sti...


US Patent US10399967 (2019)


BindingDB Entry DOI: 10.7270/Q2Z89FRQ
More data for this
Ligand-Target Pair
Interleukin-2


(Homo sapiens (Human))
BDBM412501
PNG
(5-fluoro-N-(5-(1-(6-methoxypyridin- 3-yl)-2-methyl...)
Show SMILES COc1ccc(cn1)C(=C(C)C)c1ccc(NC(=O)c2cncc(F)c2C)nc1
Show InChI InChI=1S/C22H21FN4O2/c1-13(2)21(16-6-8-20(29-4)26-10-16)15-5-7-19(25-9-15)27-22(28)17-11-24-12-18(23)14(17)3/h5-12H,1-4H3,(H,25,27,28)
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n/an/a 63n/an/an/an/an/an/a



PRCL RESEARCH INC.

US Patent


Assay Description
Human peripheral blood mononuclear cells (PBMCs) are prepared from heparinized human blood by separation over a Ficoll density gradient.PBMCs are sti...


US Patent US10399967 (2019)


BindingDB Entry DOI: 10.7270/Q2Z89FRQ
More data for this
Ligand-Target Pair
Interleukin-2


(Homo sapiens (Human))
BDBM412457
PNG
((Z)-5-fluoro-4-methyl-N-(5-(1-(4- (pyridin-2-yl)ph...)
Show SMILES C\C=C(\c1ccc(cc1)-c1ccccn1)c1ccc(NC(=O)c2cncc(F)c2C)nc1
Show InChI InChI=1S/C26H21FN4O/c1-3-21(18-7-9-19(10-8-18)24-6-4-5-13-29-24)20-11-12-25(30-14-20)31-26(32)22-15-28-16-23(27)17(22)2/h3-16H,1-2H3,(H,30,31,32)/b21-3-
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n/an/a 65n/an/an/an/an/an/a



PRCL RESEARCH INC.

US Patent


Assay Description
Human peripheral blood mononuclear cells (PBMCs) are prepared from heparinized human blood by separation over a Ficoll density gradient.PBMCs are sti...


US Patent US10399967 (2019)


BindingDB Entry DOI: 10.7270/Q2Z89FRQ
More data for this
Ligand-Target Pair
Interleukin-2


(Homo sapiens (Human))
BDBM412497
PNG
(N-(5-(2-chloro-5-(pyrimidin-2- yloxy)phenyl)pyridi...)
Show SMILES Cc1ccncc1C(=O)Nc1ccc(cn1)-c1cc(Oc2ncccn2)ccc1Cl
Show InChI InChI=1S/C22H16ClN5O2/c1-14-7-10-24-13-18(14)21(29)28-20-6-3-15(12-27-20)17-11-16(4-5-19(17)23)30-22-25-8-2-9-26-22/h2-13H,1H3,(H,27,28,29)
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n/an/a 69n/an/an/an/an/an/a



PRCL RESEARCH INC.

US Patent


Assay Description
Human peripheral blood mononuclear cells (PBMCs) are prepared from heparinized human blood by separation over a Ficoll density gradient.PBMCs are sti...


US Patent US10399967 (2019)


BindingDB Entry DOI: 10.7270/Q2Z89FRQ
More data for this
Ligand-Target Pair
Interleukin-2


(Homo sapiens (Human))
BDBM412484
PNG
(N-(5-(2-chloro-5-(1-methyl-1H- pyrazol-4-yl)phenyl...)
Show SMILES Cc1cncc(C(=O)Nc2ccc(cn2)-c2cc(ccc2Cl)-c2cnn(C)c2)c1C
Show InChI InChI=1S/C23H20ClN5O/c1-14-9-25-12-20(15(14)2)23(30)28-22-7-5-17(10-26-22)19-8-16(4-6-21(19)24)18-11-27-29(3)13-18/h4-13H,1-3H3,(H,26,28,30)
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n/an/a 72n/an/an/an/an/an/a



PRCL RESEARCH INC.

US Patent


Assay Description
Human peripheral blood mononuclear cells (PBMCs) are prepared from heparinized human blood by separation over a Ficoll density gradient.PBMCs are sti...


US Patent US10399967 (2019)


BindingDB Entry DOI: 10.7270/Q2Z89FRQ
More data for this
Ligand-Target Pair
Interleukin-2


(Homo sapiens (Human))
BDBM412390
PNG
(N-(2'-cyclopropoxy-5'-methyl-[3,4'- bipyridin]-6-y...)
Show SMILES Cc1ccncc1C(=O)Nc1ccc(cn1)-c1cc(OC2CC2)ncc1C
Show InChI InChI=1S/C21H20N4O2/c1-13-7-8-22-12-18(13)21(26)25-19-6-3-15(11-23-19)17-9-20(24-10-14(17)2)27-16-4-5-16/h3,6-12,16H,4-5H2,1-2H3,(H,23,25,26)
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n/an/a 73n/an/an/an/an/an/a



PRCL RESEARCH INC.

US Patent


Assay Description
Human peripheral blood mononuclear cells (PBMCs) are prepared from heparinized human blood by separation over a Ficoll density gradient.PBMCs are sti...


US Patent US10399967 (2019)


BindingDB Entry DOI: 10.7270/Q2Z89FRQ
More data for this
Ligand-Target Pair
Interleukin-2


(Homo sapiens (Human))
BDBM412437
PNG
(4-methyl-N-(5-(2-methyl-5-(1- methyl-1H-pyrazol-4-...)
Show SMILES Cc1ccncc1C(=O)Nc1ccc(cn1)-c1cc(ccc1C)-c1cnn(C)c1
Show InChI InChI=1S/C23H21N5O/c1-15-4-5-17(19-12-26-28(3)14-19)10-20(15)18-6-7-22(25-11-18)27-23(29)21-13-24-9-8-16(21)2/h4-14H,1-3H3,(H,25,27,29)
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n/an/a 77n/an/an/an/an/an/a



PRCL RESEARCH INC.

US Patent


Assay Description
Human peripheral blood mononuclear cells (PBMCs) are prepared from heparinized human blood by separation over a Ficoll density gradient.PBMCs are sti...


US Patent US10399967 (2019)


BindingDB Entry DOI: 10.7270/Q2Z89FRQ
More data for this
Ligand-Target Pair
Interleukin-2


(Homo sapiens (Human))
BDBM412499
PNG
(N-(5-(2-chloro-5-(1-methyl-1H- pyrazol-4-yl)phenyl...)
Show SMILES Cc1c(cncc1C(=O)Nc1cnc(cn1)-c1cc(ccc1Cl)-c1cnn(C)c1)C#N
Show InChI InChI=1S/C22H16ClN7O/c1-13-15(6-24)7-25-9-18(13)22(31)29-21-11-26-20(10-27-21)17-5-14(3-4-19(17)23)16-8-28-30(2)12-16/h3-5,7-12H,1-2H3,(H,27,29,31)
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n/an/a 77n/an/an/an/an/an/a



PRCL RESEARCH INC.

US Patent


Assay Description
Human peripheral blood mononuclear cells (PBMCs) are prepared from heparinized human blood by separation over a Ficoll density gradient.PBMCs are sti...


US Patent US10399967 (2019)


BindingDB Entry DOI: 10.7270/Q2Z89FRQ
More data for this
Ligand-Target Pair
Interleukin-2


(Homo sapiens (Human))
BDBM412410
PNG
(N-(4-(5-methoxy-2-(trifluoromethyl)- 1H-benzo[d]im...)
Show SMILES COc1ccc2n(c(nc2c1)C(F)(F)F)-c1ccc(NC(=O)c2cnccc2C)cc1
Show InChI InChI=1S/C22H17F3N4O2/c1-13-9-10-26-12-17(13)20(30)27-14-3-5-15(6-4-14)29-19-8-7-16(31-2)11-18(19)28-21(29)22(23,24)25/h3-12H,1-2H3,(H,27,30)
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n/an/a 77n/an/an/an/an/an/a



PRCL RESEARCH INC.

US Patent


Assay Description
Human peripheral blood mononuclear cells (PBMCs) are prepared from heparinized human blood by separation over a Ficoll density gradient.PBMCs are sti...


US Patent US10399967 (2019)


BindingDB Entry DOI: 10.7270/Q2Z89FRQ
More data for this
Ligand-Target Pair
Interleukin-2


(Homo sapiens (Human))
BDBM412429
PNG
(N-(5-(2-chloro-5-(1-methyl-1H- pyrazol-4-yl)phenyl...)
Show SMILES Cc1ccncc1C(=O)Nc1ccc(cn1)-c1cc(ccc1Cl)-c1cnn(C)c1
Show InChI InChI=1S/C22H18ClN5O/c1-14-7-8-24-12-19(14)22(29)27-21-6-4-16(10-25-21)18-9-15(3-5-20(18)23)17-11-26-28(2)13-17/h3-13H,1-2H3,(H,25,27,29)
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n/an/a 77n/an/an/an/an/an/a



PRCL RESEARCH INC.

US Patent


Assay Description
Human peripheral blood mononuclear cells (PBMCs) are prepared from heparinized human blood by separation over a Ficoll density gradient.PBMCs are sti...


US Patent US10399967 (2019)


BindingDB Entry DOI: 10.7270/Q2Z89FRQ
More data for this
Ligand-Target Pair
Interleukin-2


(Homo sapiens (Human))
BDBM412448
PNG
(US10399967, Compound 78 | methyl 4-(1-(5-(5-fluoro...)
Show SMILES COC(=O)c1ccc(cc1)C1(CC1)c1cnc(NC(=O)c2cncc(F)c2C)cn1
Show InChI InChI=1S/C22H19FN4O3/c1-13-16(9-24-10-17(13)23)20(28)27-19-12-25-18(11-26-19)22(7-8-22)15-5-3-14(4-6-15)21(29)30-2/h3-6,9-12H,7-8H2,1-2H3,(H,26,27,28)
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n/an/a 78n/an/an/an/an/an/a



PRCL RESEARCH INC.

US Patent


Assay Description
Human peripheral blood mononuclear cells (PBMCs) are prepared from heparinized human blood by separation over a Ficoll density gradient.PBMCs are sti...


US Patent US10399967 (2019)


BindingDB Entry DOI: 10.7270/Q2Z89FRQ
More data for this
Ligand-Target Pair
Interleukin-2


(Homo sapiens (Human))
BDBM412389
PNG
(N-(5-(2-isopropoxy-5-(1-methyl-1H- pyrazol-4-yl)ph...)
Show SMILES CC(C)Oc1ccc(cc1-c1cnc(NC(=O)c2cnccc2C)cn1)-c1cnn(C)c1
Show InChI InChI=1S/C24H24N6O2/c1-15(2)32-22-6-5-17(18-10-28-30(4)14-18)9-19(22)21-12-27-23(13-26-21)29-24(31)20-11-25-8-7-16(20)3/h5-15H,1-4H3,(H,27,29,31)
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n/an/a 79n/an/an/an/an/an/a



PRCL RESEARCH INC.

US Patent


Assay Description
Human peripheral blood mononuclear cells (PBMCs) are prepared from heparinized human blood by separation over a Ficoll density gradient.PBMCs are sti...


US Patent US10399967 (2019)


BindingDB Entry DOI: 10.7270/Q2Z89FRQ
More data for this
Ligand-Target Pair
Interleukin-2


(Homo sapiens (Human))
BDBM412408
PNG
(N-(5-(5-((3-fluoropyridin-2-yl)oxy)-2- (trifluorom...)
Show SMILES Cc1ccncc1C(=O)Nc1cnc(cn1)-c1cc(Oc2ncccc2F)ccc1OC(F)(F)F
Show InChI InChI=1S/C23H15F4N5O3/c1-13-6-8-28-10-16(13)21(33)32-20-12-30-18(11-31-20)15-9-14(4-5-19(15)35-23(25,26)27)34-22-17(24)3-2-7-29-22/h2-12H,1H3,(H,31,32,33)
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n/an/a 79n/an/an/an/an/an/a



PRCL RESEARCH INC.

US Patent


Assay Description
Human peripheral blood mononuclear cells (PBMCs) are prepared from heparinized human blood by separation over a Ficoll density gradient.PBMCs are sti...


US Patent US10399967 (2019)


BindingDB Entry DOI: 10.7270/Q2Z89FRQ
More data for this
Ligand-Target Pair
Interleukin-2


(Homo sapiens (Human))
BDBM412415
PNG
(4-methyl-N-(5-(2-methyl-5-(2- methyl-2H-tetrazol-5...)
Show SMILES Cc1ccncc1C(=O)Nc1cnc(cn1)-c1cc(ccc1C)-c1nnn(C)n1
Show InChI InChI=1S/C20H18N8O/c1-12-4-5-14(19-25-27-28(3)26-19)8-15(12)17-10-23-18(11-22-17)24-20(29)16-9-21-7-6-13(16)2/h4-11H,1-3H3,(H,23,24,29)
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n/an/a 80n/an/an/an/an/an/a



PRCL RESEARCH INC.

US Patent


Assay Description
Human peripheral blood mononuclear cells (PBMCs) are prepared from heparinized human blood by separation over a Ficoll density gradient.PBMCs are sti...


US Patent US10399967 (2019)


BindingDB Entry DOI: 10.7270/Q2Z89FRQ
More data for this
Ligand-Target Pair
Interleukin-2


(Homo sapiens (Human))
BDBM412412
PNG
(N-(4-(2,5-dimethoxy-1H- benzo[d]imidazol-1-yl)phen...)
Show SMILES COc1nc2cc(OC)ccc2n1-c1ccc(NC(=O)c2cncc(F)c2C)cc1
Show InChI InChI=1S/C22H19FN4O3/c1-13-17(11-24-12-18(13)23)21(28)25-14-4-6-15(7-5-14)27-20-9-8-16(29-2)10-19(20)26-22(27)30-3/h4-12H,1-3H3,(H,25,28)
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n/an/a 81n/an/an/an/an/an/a



PRCL RESEARCH INC.

US Patent


Assay Description
Human peripheral blood mononuclear cells (PBMCs) are prepared from heparinized human blood by separation over a Ficoll density gradient.PBMCs are sti...


US Patent US10399967 (2019)


BindingDB Entry DOI: 10.7270/Q2Z89FRQ
More data for this
Ligand-Target Pair
Interleukin-2


(Homo sapiens (Human))
BDBM412438
PNG
(4-methyl-3-(5-(4- methylnicotinamido)pyrazin-2- yl...)
Show SMILES CN(C)S(=O)(=O)Oc1ccc(C)c(c1)-c1cnc(NC(=O)c2cnccc2C)cn1
Show InChI InChI=1S/C20H21N5O4S/c1-13-5-6-15(29-30(27,28)25(3)4)9-16(13)18-11-23-19(12-22-18)24-20(26)17-10-21-8-7-14(17)2/h5-12H,1-4H3,(H,23,24,26)
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n/an/a 84n/an/an/an/an/an/a



PRCL RESEARCH INC.

US Patent


Assay Description
Human peripheral blood mononuclear cells (PBMCs) are prepared from heparinized human blood by separation over a Ficoll density gradient.PBMCs are sti...


US Patent US10399967 (2019)


BindingDB Entry DOI: 10.7270/Q2Z89FRQ
More data for this
Ligand-Target Pair
Interleukin-2


(Homo sapiens (Human))
BDBM412436
PNG
(N-(5-(5-cyclopropoxy-2- methylphenyl)pyrazin-2-yl)...)
Show SMILES Cc1ccncc1C(=O)Nc1cnc(cn1)-c1cc(OC2CC2)ccc1C
Show InChI InChI=1S/C21H20N4O2/c1-13-3-4-16(27-15-5-6-15)9-17(13)19-11-24-20(12-23-19)25-21(26)18-10-22-8-7-14(18)2/h3-4,7-12,15H,5-6H2,1-2H3,(H,24,25,26)
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n/an/a 91n/an/an/an/an/an/a



PRCL RESEARCH INC.

US Patent


Assay Description
Human peripheral blood mononuclear cells (PBMCs) are prepared from heparinized human blood by separation over a Ficoll density gradient.PBMCs are sti...


US Patent US10399967 (2019)


BindingDB Entry DOI: 10.7270/Q2Z89FRQ
More data for this
Ligand-Target Pair
Interleukin-2


(Homo sapiens (Human))
BDBM412460
PNG
(N-(5-(5-(dimethylamino)-2- methylphenyl)pyridin-2-...)
Show SMILES CN(C)c1ccc(C)c(c1)-c1ccc(NC(=O)c2cnccc2C)nc1
Show InChI InChI=1S/C21H22N4O/c1-14-5-7-17(25(3)4)11-18(14)16-6-8-20(23-12-16)24-21(26)19-13-22-10-9-15(19)2/h5-13H,1-4H3,(H,23,24,26)
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n/an/a 91n/an/an/an/an/an/a



PRCL RESEARCH INC.

US Patent


Assay Description
Human peripheral blood mononuclear cells (PBMCs) are prepared from heparinized human blood by separation over a Ficoll density gradient.PBMCs are sti...


US Patent US10399967 (2019)


BindingDB Entry DOI: 10.7270/Q2Z89FRQ
More data for this
Ligand-Target Pair
Interleukin-2


(Homo sapiens (Human))
BDBM412402
PNG
(4-methyl-N-(5-(2-methyl-5-(pyridin- 2-yloxy)phenyl...)
Show SMILES Cc1ccncc1C(=O)Nc1ccc(cn1)-c1cc(Oc2ccccn2)ccc1C
Show InChI InChI=1S/C24H20N4O2/c1-16-6-8-19(30-23-5-3-4-11-26-23)13-20(16)18-7-9-22(27-14-18)28-24(29)21-15-25-12-10-17(21)2/h3-15H,1-2H3,(H,27,28,29)
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n/an/a 91n/an/an/an/an/an/a



PRCL RESEARCH INC.

US Patent


Assay Description
Human peripheral blood mononuclear cells (PBMCs) are prepared from heparinized human blood by separation over a Ficoll density gradient.PBMCs are sti...


US Patent US10399967 (2019)


BindingDB Entry DOI: 10.7270/Q2Z89FRQ
More data for this
Ligand-Target Pair
Interleukin-2


(Homo sapiens (Human))
BDBM412435
PNG
(N-(5-(5-methoxy-2-(trifluoromethyl)- 1H-benzo[d]im...)
Show SMILES COc1ccc2n(c(nc2c1)C(F)(F)F)-c1cnc(NC(=O)c2cnccc2C)cn1
Show InChI InChI=1S/C20H15F3N6O2/c1-11-5-6-24-8-13(11)18(30)28-16-9-26-17(10-25-16)29-15-4-3-12(31-2)7-14(15)27-19(29)20(21,22)23/h3-10H,1-2H3,(H,25,28,30)
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n/an/a 93n/an/an/an/an/an/a



PRCL RESEARCH INC.

US Patent


Assay Description
Human peripheral blood mononuclear cells (PBMCs) are prepared from heparinized human blood by separation over a Ficoll density gradient.PBMCs are sti...


US Patent US10399967 (2019)


BindingDB Entry DOI: 10.7270/Q2Z89FRQ
More data for this
Ligand-Target Pair
Interleukin-2


(Homo sapiens (Human))
BDBM412385
PNG
(N-(5-(2-chloro-5-((3-fluoropyridin-2- yl)amino)phe...)
Show SMILES Cc1ccncc1C(=O)Nc1ccc(cn1)-c1cc(Nc2ncccc2F)ccc1Cl
Show InChI InChI=1S/C23H17ClFN5O/c1-14-8-10-26-13-18(14)23(31)30-21-7-4-15(12-28-21)17-11-16(5-6-19(17)24)29-22-20(25)3-2-9-27-22/h2-13H,1H3,(H,27,29)(H,28,30,31)
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n/an/a 104n/an/an/an/an/an/a



PRCL RESEARCH INC.

US Patent


Assay Description
Human peripheral blood mononuclear cells (PBMCs) are prepared from heparinized human blood by separation over a Ficoll density gradient.PBMCs are sti...


US Patent US10399967 (2019)


BindingDB Entry DOI: 10.7270/Q2Z89FRQ
More data for this
Ligand-Target Pair
Interleukin-2


(Homo sapiens (Human))
BDBM412401
PNG
(5-fluoro-N-(4-(1-(4- methoxyphenyl)cyclopropyl)phe...)
Show SMILES COc1ccc(cc1)C1(CC1)c1ccc(NC(=O)c2cncc(F)c2C)cc1
Show InChI InChI=1S/C23H21FN2O2/c1-15-20(13-25-14-21(15)24)22(27)26-18-7-3-16(4-8-18)23(11-12-23)17-5-9-19(28-2)10-6-17/h3-10,13-14H,11-12H2,1-2H3,(H,26,27)
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n/an/a 104n/an/an/an/an/an/a



PRCL RESEARCH INC.

US Patent


Assay Description
Human peripheral blood mononuclear cells (PBMCs) are prepared from heparinized human blood by separation over a Ficoll density gradient.PBMCs are sti...


US Patent US10399967 (2019)


BindingDB Entry DOI: 10.7270/Q2Z89FRQ
More data for this
Ligand-Target Pair
Interleukin-2


(Homo sapiens (Human))
BDBM412465
PNG
((Z)-N-(5-(1-(4-bromophenyl)prop-1- en-1-yl)pyridin...)
Show SMILES C\C=C(\c1ccc(Br)cc1)c1ccc(NC(=O)c2cncc(F)c2C)nc1
Show InChI InChI=1S/C21H17BrFN3O/c1-3-17(14-4-7-16(22)8-5-14)15-6-9-20(25-10-15)26-21(27)18-11-24-12-19(23)13(18)2/h3-12H,1-2H3,(H,25,26,27)/b17-3-
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n/an/a 105n/an/an/an/an/an/a



PRCL RESEARCH INC.

US Patent


Assay Description
Human peripheral blood mononuclear cells (PBMCs) are prepared from heparinized human blood by separation over a Ficoll density gradient.PBMCs are sti...


US Patent US10399967 (2019)


BindingDB Entry DOI: 10.7270/Q2Z89FRQ
More data for this
Ligand-Target Pair
Interleukin-2


(Homo sapiens (Human))
BDBM412458
PNG
((Z)-N-(5-(1-(4-cyanophenyl)prop-1- en-1-yl)pyridin...)
Show SMILES C\C=C(\c1ccc(cc1)C#N)c1ccc(NC(=O)c2cncc(F)c2C)nc1
Show InChI InChI=1S/C22H17FN4O/c1-3-18(16-6-4-15(10-24)5-7-16)17-8-9-21(26-11-17)27-22(28)19-12-25-13-20(23)14(19)2/h3-9,11-13H,1-2H3,(H,26,27,28)/b18-3-
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n/an/a 113n/an/an/an/an/an/a



PRCL RESEARCH INC.

US Patent


Assay Description
Human peripheral blood mononuclear cells (PBMCs) are prepared from heparinized human blood by separation over a Ficoll density gradient.PBMCs are sti...


US Patent US10399967 (2019)


BindingDB Entry DOI: 10.7270/Q2Z89FRQ
More data for this
Ligand-Target Pair
Interleukin-2


(Homo sapiens (Human))
BDBM412431
PNG
(N-(5-(2,5-dimethoxy-1H- benzo[d]imidazol-1-yl)pyra...)
Show SMILES COc1nc2cc(OC)ccc2n1-c1cnc(NC(=O)c2cnccc2C)cn1
Show InChI InChI=1S/C20H18N6O3/c1-12-6-7-21-9-14(12)19(27)25-17-10-23-18(11-22-17)26-16-5-4-13(28-2)8-15(16)24-20(26)29-3/h4-11H,1-3H3,(H,22,25,27)
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n/an/a 113n/an/an/an/an/an/a



PRCL RESEARCH INC.

US Patent


Assay Description
Human peripheral blood mononuclear cells (PBMCs) are prepared from heparinized human blood by separation over a Ficoll density gradient.PBMCs are sti...


US Patent US10399967 (2019)


BindingDB Entry DOI: 10.7270/Q2Z89FRQ
More data for this
Ligand-Target Pair
Interleukin-2


(Homo sapiens (Human))
BDBM412398
PNG
(N-(2'-cyclopropoxy-5'-methyl-[3,4'- bipyridin]-6-y...)
Show SMILES Cc1cnc(OC2CC2)cc1-c1ccc(NC(=O)c2cncc(F)c2C)nc1
Show InChI InChI=1S/C21H19FN4O2/c1-12-8-25-20(28-15-4-5-15)7-16(12)14-3-6-19(24-9-14)26-21(27)17-10-23-11-18(22)13(17)2/h3,6-11,15H,4-5H2,1-2H3,(H,24,26,27)
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n/an/a 114n/an/an/an/an/an/a



PRCL RESEARCH INC.

US Patent


Assay Description
Human peripheral blood mononuclear cells (PBMCs) are prepared from heparinized human blood by separation over a Ficoll density gradient.PBMCs are sti...


US Patent US10399967 (2019)


BindingDB Entry DOI: 10.7270/Q2Z89FRQ
More data for this
Ligand-Target Pair
Interleukin-2


(Homo sapiens (Human))
BDBM412477
PNG
(N-(5-(2-methoxy-5-(1-methyl-1H- pyrazol-4-yl)pheny...)
Show SMILES COc1ccc(cc1-c1cnc(NC(=O)c2cnccc2C)cn1)-c1cnn(C)c1
Show InChI InChI=1S/C22H20N6O2/c1-14-6-7-23-10-18(14)22(29)27-21-12-24-19(11-25-21)17-8-15(4-5-20(17)30-3)16-9-26-28(2)13-16/h4-13H,1-3H3,(H,25,27,29)
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n/an/a 116n/an/an/an/an/an/a



PRCL RESEARCH INC.

US Patent


Assay Description
Human peripheral blood mononuclear cells (PBMCs) are prepared from heparinized human blood by separation over a Ficoll density gradient.PBMCs are sti...


US Patent US10399967 (2019)


BindingDB Entry DOI: 10.7270/Q2Z89FRQ
More data for this
Ligand-Target Pair
Interleukin-2


(Homo sapiens (Human))
BDBM412417
PNG
(5-fluoro-N-(6-(5-methoxy-2- (trifluoromethyl)-1H- ...)
Show SMILES COc1ccc2n(c(nc2c1)C(F)(F)F)-c1ccc(NC(=O)c2cncc(F)c2C)cn1
Show InChI InChI=1S/C21H15F4N5O2/c1-11-14(9-26-10-15(11)22)19(31)28-12-3-6-18(27-8-12)30-17-5-4-13(32-2)7-16(17)29-20(30)21(23,24)25/h3-10H,1-2H3,(H,28,31)
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n/an/a 116n/an/an/an/an/an/a



PRCL RESEARCH INC.

US Patent


Assay Description
Human peripheral blood mononuclear cells (PBMCs) are prepared from heparinized human blood by separation over a Ficoll density gradient.PBMCs are sti...


US Patent US10399967 (2019)


BindingDB Entry DOI: 10.7270/Q2Z89FRQ
More data for this
Ligand-Target Pair
Interleukin-2


(Homo sapiens (Human))
BDBM412471
PNG
(N-(5-(1-(4-methoxyphenyl)-2- methylprop-1-en-1-yl)...)
Show SMILES COc1ccc(cc1)C(=C(C)C)c1ccc(NC(=O)c2cnccc2C)nc1
Show InChI InChI=1S/C23H23N3O2/c1-15(2)22(17-5-8-19(28-4)9-6-17)18-7-10-21(25-13-18)26-23(27)20-14-24-12-11-16(20)3/h5-14H,1-4H3,(H,25,26,27)
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n/an/a 116n/an/an/an/an/an/a



PRCL RESEARCH INC.

US Patent


Assay Description
Human peripheral blood mononuclear cells (PBMCs) are prepared from heparinized human blood by separation over a Ficoll density gradient.PBMCs are sti...


US Patent US10399967 (2019)


BindingDB Entry DOI: 10.7270/Q2Z89FRQ
More data for this
Ligand-Target Pair
Interleukin-2


(Homo sapiens (Human))
BDBM412478
PNG
((Z)-5-fluoro-4-methyl-N-(5-(1-(4-(1- methyl-1H-pyr...)
Show SMILES C\C=C(\c1ccc(cc1)-c1cnn(C)c1)c1ccc(NC(=O)c2cncc(F)c2C)nc1
Show InChI InChI=1S/C25H22FN5O/c1-4-21(18-7-5-17(6-8-18)20-12-29-31(3)15-20)19-9-10-24(28-11-19)30-25(32)22-13-27-14-23(26)16(22)2/h4-15H,1-3H3,(H,28,30,32)/b21-4-
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n/an/a 118n/an/an/an/an/an/a



PRCL RESEARCH INC.

US Patent


Assay Description
Human peripheral blood mononuclear cells (PBMCs) are prepared from heparinized human blood by separation over a Ficoll density gradient.PBMCs are sti...


US Patent US10399967 (2019)


BindingDB Entry DOI: 10.7270/Q2Z89FRQ
More data for this
Ligand-Target Pair
Interleukin-2


(Homo sapiens (Human))
BDBM412470
PNG
(4-methyl-N-(5-(2-methyl-5-(1- methyl-1H-pyrazol-3-...)
Show SMILES Cc1ccncc1C(=O)Nc1cnc(cn1)-c1cc(ccc1C)-c1ccn(C)n1
Show InChI InChI=1S/C22H20N6O/c1-14-4-5-16(19-7-9-28(3)27-19)10-17(14)20-12-25-21(13-24-20)26-22(29)18-11-23-8-6-15(18)2/h4-13H,1-3H3,(H,25,26,29)
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n/an/a 127n/an/an/an/an/an/a



PRCL RESEARCH INC.

US Patent


Assay Description
Human peripheral blood mononuclear cells (PBMCs) are prepared from heparinized human blood by separation over a Ficoll density gradient.PBMCs are sti...


US Patent US10399967 (2019)


BindingDB Entry DOI: 10.7270/Q2Z89FRQ
More data for this
Ligand-Target Pair
Interleukin-2


(Homo sapiens (Human))
BDBM412395
PNG
((Z)-5-fluoro-N-(5-((4-methoxy-2- methylphenyl)(met...)
Show SMILES CO\N=C(/c1ccc(NC(=O)c2cncc(F)c2C)nc1)c1ccc(OC)cc1C
Show InChI InChI=1S/C22H21FN4O3/c1-13-9-16(29-3)6-7-17(13)21(27-30-4)15-5-8-20(25-10-15)26-22(28)18-11-24-12-19(23)14(18)2/h5-12H,1-4H3,(H,25,26,28)/b27-21+
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n/an/a 130n/an/an/an/an/an/a



PRCL RESEARCH INC.

US Patent


Assay Description
Human peripheral blood mononuclear cells (PBMCs) are prepared from heparinized human blood by separation over a Ficoll density gradient.PBMCs are sti...


US Patent US10399967 (2019)


BindingDB Entry DOI: 10.7270/Q2Z89FRQ
More data for this
Ligand-Target Pair
Interleukin-2


(Homo sapiens (Human))
BDBM412430
PNG
(N-(5-(5-cyclopropoxy-2- methylphenyl)pyridin-2-yl)...)
Show SMILES Cc1ccncc1C(=O)Nc1ccc(cn1)-c1cc(OC2CC2)ccc1C
Show InChI InChI=1S/C22H21N3O2/c1-14-3-5-18(27-17-6-7-17)11-19(14)16-4-8-21(24-12-16)25-22(26)20-13-23-10-9-15(20)2/h3-5,8-13,17H,6-7H2,1-2H3,(H,24,25,26)
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n/an/a 132n/an/an/an/an/an/a



PRCL RESEARCH INC.

US Patent


Assay Description
Human peripheral blood mononuclear cells (PBMCs) are prepared from heparinized human blood by separation over a Ficoll density gradient.PBMCs are sti...


US Patent US10399967 (2019)


BindingDB Entry DOI: 10.7270/Q2Z89FRQ
More data for this
Ligand-Target Pair
Interleukin-2


(Homo sapiens (Human))
BDBM412406
PNG
(N-(5-(5-((3-fluoropyridin-2-yl)oxy)-2- methylpheny...)
Show SMILES Cc1ccncc1C(=O)Nc1cnc(cn1)-c1cc(Oc2ncccc2F)ccc1C
Show InChI InChI=1S/C23H18FN5O2/c1-14-5-6-16(31-23-19(24)4-3-8-26-23)10-17(14)20-12-28-21(13-27-20)29-22(30)18-11-25-9-7-15(18)2/h3-13H,1-2H3,(H,28,29,30)
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n/an/a 134n/an/an/an/an/an/a



PRCL RESEARCH INC.

US Patent


Assay Description
Human peripheral blood mononuclear cells (PBMCs) are prepared from heparinized human blood by separation over a Ficoll density gradient.PBMCs are sti...


US Patent US10399967 (2019)


BindingDB Entry DOI: 10.7270/Q2Z89FRQ
More data for this
Ligand-Target Pair
Interleukin-2


(Homo sapiens (Human))
BDBM412508
PNG
((E)-5-fluoro-4-methyl-N-(5-(1-(6- (pyrrolidin-1-yl...)
Show SMILES C\C=C(/c1ccc(NC(=O)c2cncc(F)c2C)nc1)c1ccc(nc1)N1CCCC1
Show InChI InChI=1S/C24H24FN5O/c1-3-19(18-7-9-23(28-13-18)30-10-4-5-11-30)17-6-8-22(27-12-17)29-24(31)20-14-26-15-21(25)16(20)2/h3,6-9,12-15H,4-5,10-11H2,1-2H3,(H,27,29,31)/b19-3+
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n/an/a 135n/an/an/an/an/an/a



PRCL RESEARCH INC.

US Patent


Assay Description
Human peripheral blood mononuclear cells (PBMCs) are prepared from heparinized human blood by separation over a Ficoll density gradient.PBMCs are sti...


US Patent US10399967 (2019)


BindingDB Entry DOI: 10.7270/Q2Z89FRQ
More data for this
Ligand-Target Pair
Interleukin-2


(Homo sapiens (Human))
BDBM412414
PNG
(4-methyl-N-(5-(2-methyl-5-(pyridin- 3-ylethynyl)ph...)
Show SMILES Cc1ccncc1C(=O)Nc1cnc(cn1)-c1cc(ccc1C)C#Cc1cccnc1
Show InChI InChI=1S/C25H19N5O/c1-17-5-6-19(7-8-20-4-3-10-26-13-20)12-21(17)23-15-29-24(16-28-23)30-25(31)22-14-27-11-9-18(22)2/h3-6,9-16H,1-2H3,(H,29,30,31)
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n/an/a 140n/an/an/an/an/an/a



PRCL RESEARCH INC.

US Patent


Assay Description
Human peripheral blood mononuclear cells (PBMCs) are prepared from heparinized human blood by separation over a Ficoll density gradient.PBMCs are sti...


US Patent US10399967 (2019)


BindingDB Entry DOI: 10.7270/Q2Z89FRQ
More data for this
Ligand-Target Pair
Interleukin-2


(Homo sapiens (Human))
BDBM412486
PNG
(5-fluoro-N-(5-(1-(6-methoxypyridin- 3-yl)propyl)py...)
Show SMILES CCC(c1ccc(NC(=O)c2cncc(F)c2C)nc1)c1ccc(OC)nc1
Show InChI InChI=1S/C21H21FN4O2/c1-4-16(15-6-8-20(28-3)25-10-15)14-5-7-19(24-9-14)26-21(27)17-11-23-12-18(22)13(17)2/h5-12,16H,4H2,1-3H3,(H,24,26,27)
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n/an/a 140n/an/an/an/an/an/a



PRCL RESEARCH INC.

US Patent


Assay Description
Human peripheral blood mononuclear cells (PBMCs) are prepared from heparinized human blood by separation over a Ficoll density gradient.PBMCs are sti...


US Patent US10399967 (2019)


BindingDB Entry DOI: 10.7270/Q2Z89FRQ
More data for this
Ligand-Target Pair
Interleukin-2


(Homo sapiens (Human))
BDBM412505
PNG
(N-(5-(2-chloro-5- (dimethylamino)phenyl)pyridin-2-...)
Show SMILES CN(C)c1ccc(Cl)c(c1)-c1ccc(NC(=O)c2cnccc2C)nc1
Show InChI InChI=1S/C20H19ClN4O/c1-13-8-9-22-12-17(13)20(26)24-19-7-4-14(11-23-19)16-10-15(25(2)3)5-6-18(16)21/h4-12H,1-3H3,(H,23,24,26)
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n/an/a 146n/an/an/an/an/an/a



PRCL RESEARCH INC.

US Patent


Assay Description
Human peripheral blood mononuclear cells (PBMCs) are prepared from heparinized human blood by separation over a Ficoll density gradient.PBMCs are sti...


US Patent US10399967 (2019)


BindingDB Entry DOI: 10.7270/Q2Z89FRQ
More data for this
Ligand-Target Pair
Interleukin-2


(Homo sapiens (Human))
BDBM412416
PNG
(N-(6-(5-methoxy-2-(trifluoromethyl)- 1H-benzo[d]im...)
Show SMILES COc1ccc2n(c(nc2c1)C(F)(F)F)-c1ccc(NC(=O)c2cnccc2C)cn1
Show InChI InChI=1S/C21H16F3N5O2/c1-12-7-8-25-11-15(12)19(30)27-13-3-6-18(26-10-13)29-17-5-4-14(31-2)9-16(17)28-20(29)21(22,23)24/h3-11H,1-2H3,(H,27,30)
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n/an/a 156n/an/an/an/an/an/a



PRCL RESEARCH INC.

US Patent


Assay Description
Human peripheral blood mononuclear cells (PBMCs) are prepared from heparinized human blood by separation over a Ficoll density gradient.PBMCs are sti...


US Patent US10399967 (2019)


BindingDB Entry DOI: 10.7270/Q2Z89FRQ
More data for this
Ligand-Target Pair
Interleukin-2


(Homo sapiens (Human))
BDBM412454
PNG
((Z)-5-fluoro-N-(5-(1-(4- hydroxyphenyl)prop-1-en-1...)
Show SMILES C\C=C(\c1ccc(O)cc1)c1ccc(NC(=O)c2cncc(F)c2C)nc1
Show InChI InChI=1S/C21H18FN3O2/c1-3-17(14-4-7-16(26)8-5-14)15-6-9-20(24-10-15)25-21(27)18-11-23-12-19(22)13(18)2/h3-12,26H,1-2H3,(H,24,25,27)/b17-3-
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n/an/a 173n/an/an/an/an/an/a



PRCL RESEARCH INC.

US Patent


Assay Description
Human peripheral blood mononuclear cells (PBMCs) are prepared from heparinized human blood by separation over a Ficoll density gradient.PBMCs are sti...


US Patent US10399967 (2019)


BindingDB Entry DOI: 10.7270/Q2Z89FRQ
More data for this
Ligand-Target Pair
Interleukin-2


(Homo sapiens (Human))
BDBM412405
PNG
(N-(4-(2-(difluoromethyl)-5-methoxy- 1H-benzo[d]imi...)
Show SMILES COc1ccc2n(c(nc2c1)C(F)F)-c1ccc(NC(=O)c2cnccc2C)cc1
Show InChI InChI=1S/C22H18F2N4O2/c1-13-9-10-25-12-17(13)22(29)26-14-3-5-15(6-4-14)28-19-8-7-16(30-2)11-18(19)27-21(28)20(23)24/h3-12,20H,1-2H3,(H,26,29)
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n/an/a 190n/an/an/an/an/an/a



PRCL RESEARCH INC.

US Patent


Assay Description
Human peripheral blood mononuclear cells (PBMCs) are prepared from heparinized human blood by separation over a Ficoll density gradient.PBMCs are sti...


US Patent US10399967 (2019)


BindingDB Entry DOI: 10.7270/Q2Z89FRQ
More data for this
Ligand-Target Pair
Interleukin-2


(Homo sapiens (Human))
BDBM412375
PNG
(N-(4-(1-(4-bromophenyl)vinyl)-3- methylphenyl)-5-f...)
Show SMILES Cc1cc(NC(=O)c2cncc(F)c2C)ccc1C(=C)c1ccc(Br)cc1
Show InChI InChI=1S/C22H18BrFN2O/c1-13-10-18(26-22(27)20-11-25-12-21(24)15(20)3)8-9-19(13)14(2)16-4-6-17(23)7-5-16/h4-12H,2H2,1,3H3,(H,26,27)
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n/an/a 202n/an/an/an/an/an/a



PRCL RESEARCH INC.

US Patent


Assay Description
Human peripheral blood mononuclear cells (PBMCs) are prepared from heparinized human blood by separation over a Ficoll density gradient.PBMCs are sti...


US Patent US10399967 (2019)


BindingDB Entry DOI: 10.7270/Q2Z89FRQ
More data for this
Ligand-Target Pair
Interleukin-2


(Homo sapiens (Human))
BDBM412420
PNG
(4-methyl-N-(5-(6- methylbenzo[d][1,3]dioxol-5- yl)...)
Show SMILES Cc1ccncc1C(=O)Nc1cnc(cn1)-c1cc2OCOc2cc1C
Show InChI InChI=1S/C19H16N4O3/c1-11-3-4-20-7-14(11)19(24)23-18-9-21-15(8-22-18)13-6-17-16(5-12(13)2)25-10-26-17/h3-9H,10H2,1-2H3,(H,22,23,24)
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n/an/a 205n/an/an/an/an/an/a



PRCL RESEARCH INC.

US Patent


Assay Description
Human peripheral blood mononuclear cells (PBMCs) are prepared from heparinized human blood by separation over a Ficoll density gradient.PBMCs are sti...


US Patent US10399967 (2019)


BindingDB Entry DOI: 10.7270/Q2Z89FRQ
More data for this
Ligand-Target Pair
Interleukin-2


(Homo sapiens (Human))
BDBM412399
PNG
((Z)-N-(5-((ethoxyimino)(4- methoxyphenyl)methyl)py...)
Show SMILES CCO\N=C(\c1ccc(OC)cc1)c1ccc(NC(=O)c2cncc(F)c2C)nc1
Show InChI InChI=1S/C22H21FN4O3/c1-4-30-27-21(15-5-8-17(29-3)9-6-15)16-7-10-20(25-11-16)26-22(28)18-12-24-13-19(23)14(18)2/h5-13H,4H2,1-3H3,(H,25,26,28)/b27-21-
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n/an/a 210n/an/an/an/an/an/a



PRCL RESEARCH INC.

US Patent


Assay Description
Human peripheral blood mononuclear cells (PBMCs) are prepared from heparinized human blood by separation over a Ficoll density gradient.PBMCs are sti...


US Patent US10399967 (2019)


BindingDB Entry DOI: 10.7270/Q2Z89FRQ
More data for this
Ligand-Target Pair
Interleukin-2


(Homo sapiens (Human))
BDBM412400
PNG
((E)-5-fluoro-N-(5-((methoxyimino)(6- methoxypyridi...)
Show SMILES CO\N=C(/c1ccc(NC(=O)c2cncc(F)c2C)nc1)c1ccc(OC)nc1
Show InChI InChI=1S/C20H18FN5O3/c1-12-15(10-22-11-16(12)21)20(27)25-17-6-4-13(8-23-17)19(26-29-3)14-5-7-18(28-2)24-9-14/h4-11H,1-3H3,(H,23,25,27)/b26-19+
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n/an/a 247n/an/an/an/an/an/a



PRCL RESEARCH INC.

US Patent


Assay Description
Human peripheral blood mononuclear cells (PBMCs) are prepared from heparinized human blood by separation over a Ficoll density gradient.PBMCs are sti...


US Patent US10399967 (2019)


BindingDB Entry DOI: 10.7270/Q2Z89FRQ
More data for this
Ligand-Target Pair
Interleukin-2


(Homo sapiens (Human))
BDBM412439
PNG
(4-methyl-3-(5-(4- methylnicotinamido)pyrazin-2- yl...)
Show SMILES Cc1ccncc1C(=O)Nc1cnc(cn1)-c1cc(OS(C)(=O)=O)ccc1C
Show InChI InChI=1S/C19H18N4O4S/c1-12-4-5-14(27-28(3,25)26)8-15(12)17-10-22-18(11-21-17)23-19(24)16-9-20-7-6-13(16)2/h4-11H,1-3H3,(H,22,23,24)
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n/an/a 264n/an/an/an/an/an/a



PRCL RESEARCH INC.

US Patent


Assay Description
Human peripheral blood mononuclear cells (PBMCs) are prepared from heparinized human blood by separation over a Ficoll density gradient.PBMCs are sti...


US Patent US10399967 (2019)


BindingDB Entry DOI: 10.7270/Q2Z89FRQ
More data for this
Ligand-Target Pair
Interleukin-2


(Homo sapiens (Human))
BDBM412464
PNG
(5-fluoro-N-(5-(1-(4- methoxyphenyl)cyclopropyl)pyr...)
Show SMILES COc1ccc(cc1)C1(CC1)c1cnc(NC(=O)c2cncc(F)c2C)cn1
Show InChI InChI=1S/C21H19FN4O2/c1-13-16(9-23-10-17(13)22)20(27)26-19-12-24-18(11-25-19)21(7-8-21)14-3-5-15(28-2)6-4-14/h3-6,9-12H,7-8H2,1-2H3,(H,25,26,27)
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n/an/a 274n/an/an/an/an/an/a



PRCL RESEARCH INC.

US Patent


Assay Description
Human peripheral blood mononuclear cells (PBMCs) are prepared from heparinized human blood by separation over a Ficoll density gradient.PBMCs are sti...


US Patent US10399967 (2019)


BindingDB Entry DOI: 10.7270/Q2Z89FRQ
More data for this
Ligand-Target Pair
Interleukin-2


(Homo sapiens (Human))
BDBM412452
PNG
((E)-5-fluoro-N-(5-(1-(6-fluoropyridin- 3-yl)prop-1...)
Show SMILES C\C=C(\c1ccc(F)nc1)c1ccc(NC(=O)c2cncc(F)c2C)nc1
Show InChI InChI=1S/C20H16F2N4O/c1-3-15(13-4-6-18(22)24-8-13)14-5-7-19(25-9-14)26-20(27)16-10-23-11-17(21)12(16)2/h3-11H,1-2H3,(H,25,26,27)/b15-3-
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n/an/a 277n/an/an/an/an/an/a



PRCL RESEARCH INC.

US Patent


Assay Description
Human peripheral blood mononuclear cells (PBMCs) are prepared from heparinized human blood by separation over a Ficoll density gradient.PBMCs are sti...


US Patent US10399967 (2019)


BindingDB Entry DOI: 10.7270/Q2Z89FRQ
More data for this
Ligand-Target Pair
Interleukin-2


(Homo sapiens (Human))
BDBM412413
PNG
(N-(4-(2,5-dimethoxy-1H- benzo[d]imidazol-1-yl)phen...)
Show SMILES COc1nc2cc(OC)ccc2n1-c1ccc(NC(=O)c2cnccc2C)cc1
Show InChI InChI=1S/C22H20N4O3/c1-14-10-11-23-13-18(14)21(27)24-15-4-6-16(7-5-15)26-20-9-8-17(28-2)12-19(20)25-22(26)29-3/h4-13H,1-3H3,(H,24,27)
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n/an/a 352n/an/an/an/an/an/a



PRCL RESEARCH INC.

US Patent


Assay Description
Human peripheral blood mononuclear cells (PBMCs) are prepared from heparinized human blood by separation over a Ficoll density gradient.PBMCs are sti...


US Patent US10399967 (2019)


BindingDB Entry DOI: 10.7270/Q2Z89FRQ
More data for this
Ligand-Target Pair
Interleukin-2


(Homo sapiens (Human))
BDBM412493
PNG
((Z)-5-fluoro-4-methyl-N-(5-(1-(1- methyl-1H-pyrazo...)
Show SMILES C\C=C(/c1cnn(C)c1)c1ccc(NC(=O)c2cncc(F)c2C)nc1
Show InChI InChI=1S/C19H18FN5O/c1-4-15(14-8-23-25(3)11-14)13-5-6-18(22-7-13)24-19(26)16-9-21-10-17(20)12(16)2/h4-11H,1-3H3,(H,22,24,26)/b15-4-
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n/an/a 455n/an/an/an/an/an/a



PRCL RESEARCH INC.

US Patent


Assay Description
Human peripheral blood mononuclear cells (PBMCs) are prepared from heparinized human blood by separation over a Ficoll density gradient.PBMCs are sti...


US Patent US10399967 (2019)


BindingDB Entry DOI: 10.7270/Q2Z89FRQ
More data for this
Ligand-Target Pair
Interleukin-2


(Homo sapiens (Human))
BDBM412491
PNG
(4-methyl-N-(5-(2-methyl-5-(2- methylthiazol-4-yl)p...)
Show SMILES Cc1nc(cs1)-c1ccc(C)c(c1)-c1cnc(NC(=O)c2cnccc2C)cn1
Show InChI InChI=1S/C22H19N5OS/c1-13-4-5-16(20-12-29-15(3)26-20)8-17(13)19-10-25-21(11-24-19)27-22(28)18-9-23-7-6-14(18)2/h4-12H,1-3H3,(H,25,27,28)
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n/an/a 477n/an/an/an/an/an/a



PRCL RESEARCH INC.

US Patent


Assay Description
Human peripheral blood mononuclear cells (PBMCs) are prepared from heparinized human blood by separation over a Ficoll density gradient.PBMCs are sti...


US Patent US10399967 (2019)


BindingDB Entry DOI: 10.7270/Q2Z89FRQ
More data for this
Ligand-Target Pair
Interleukin-2


(Homo sapiens (Human))
BDBM412382
PNG
((Z)-4-methyl-N-(5-(1-(4-(1-methyl- 1H-pyrazol-4-yl...)
Show SMILES C\C=C(\c1ccc(cc1)-c1cnn(C)c1)c1cnc(NC(=O)c2cnccc2C)cn1
Show InChI InChI=1S/C24H22N6O/c1-4-20(18-7-5-17(6-8-18)19-11-28-30(3)15-19)22-13-27-23(14-26-22)29-24(31)21-12-25-10-9-16(21)2/h4-15H,1-3H3,(H,27,29,31)/b20-4-
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n/an/a 763n/an/an/an/an/an/a



PRCL RESEARCH INC.

US Patent


Assay Description
Human peripheral blood mononuclear cells (PBMCs) are prepared from heparinized human blood by separation over a Ficoll density gradient.PBMCs are sti...


US Patent US10399967 (2019)


BindingDB Entry DOI: 10.7270/Q2Z89FRQ
More data for this
Ligand-Target Pair
Interleukin-2


(Homo sapiens (Human))
BDBM412478
PNG
((Z)-5-fluoro-4-methyl-N-(5-(1-(4-(1- methyl-1H-pyr...)
Show SMILES C\C=C(\c1ccc(cc1)-c1cnn(C)c1)c1ccc(NC(=O)c2cncc(F)c2C)nc1
Show InChI InChI=1S/C25H22FN5O/c1-4-21(18-7-5-17(6-8-18)20-12-29-31(3)15-20)19-9-10-24(28-11-19)30-25(32)22-13-27-14-23(26)16(22)2/h4-15H,1-3H3,(H,28,30,32)/b21-4-
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n/an/a 876n/an/an/an/an/an/a



PRCL RESEARCH INC.

US Patent


Assay Description
Human peripheral blood mononuclear cells (PBMCs) are prepared from heparinized human blood by separation over a Ficoll density gradient.PBMCs are sti...


US Patent US10399967 (2019)


BindingDB Entry DOI: 10.7270/Q2Z89FRQ
More data for this
Ligand-Target Pair
Interleukin-2


(Homo sapiens (Human))
BDBM412494
PNG
((Z)-5-fluoro-4-methyl-N-(5-(1-(4- (methylsulfonyl)...)
Show SMILES C\C=C(\c1ccc(cc1)S(C)(=O)=O)c1ccc(NC(=O)c2cncc(F)c2C)nc1
Show InChI InChI=1S/C22H20FN3O3S/c1-4-18(15-5-8-17(9-6-15)30(3,28)29)16-7-10-21(25-11-16)26-22(27)19-12-24-13-20(23)14(19)2/h4-13H,1-3H3,(H,25,26,27)/b18-4-
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n/an/a 1.00E+3n/an/an/an/an/an/a



PRCL RESEARCH INC.

US Patent


Assay Description
Human peripheral blood mononuclear cells (PBMCs) are prepared from heparinized human blood by separation over a Ficoll density gradient.PBMCs are sti...


US Patent US10399967 (2019)


BindingDB Entry DOI: 10.7270/Q2Z89FRQ
More data for this
Ligand-Target Pair
Interleukin-2


(Homo sapiens (Human))
BDBM412391
PNG
(4-methyl-N-(6-methyl-5-(3- (trifluoromethoxy)pheny...)
Show SMILES Cc1ccncc1C(=O)Nc1cnc(c(C)n1)-c1cccc(OC(F)(F)F)c1
Show InChI InChI=1S/C19H15F3N4O2/c1-11-6-7-23-9-15(11)18(27)26-16-10-24-17(12(2)25-16)13-4-3-5-14(8-13)28-19(20,21)22/h3-10H,1-2H3,(H,25,26,27)
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n/an/a 1.00E+3n/an/an/an/an/an/a



PRCL RESEARCH INC.

US Patent


Assay Description
Human peripheral blood mononuclear cells (PBMCs) are prepared from heparinized human blood by separation over a Ficoll density gradient.PBMCs are sti...


US Patent US10399967 (2019)


BindingDB Entry DOI: 10.7270/Q2Z89FRQ
More data for this
Ligand-Target Pair
Interleukin-2


(Homo sapiens (Human))
BDBM412502
PNG
(5-fluoro-4-methyl-N-(5-(1-(1-methyl- 1H-pyrazol-4-...)
Show SMILES CCC(c1cnn(C)c1)c1ccc(NC(=O)c2cncc(F)c2C)nc1
Show InChI InChI=1S/C19H20FN5O/c1-4-15(14-8-23-25(3)11-14)13-5-6-18(22-7-13)24-19(26)16-9-21-10-17(20)12(16)2/h5-11,15H,4H2,1-3H3,(H,22,24,26)
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n/an/a 1.00E+3n/an/an/an/an/an/a



PRCL RESEARCH INC.

US Patent


Assay Description
Human peripheral blood mononuclear cells (PBMCs) are prepared from heparinized human blood by separation over a Ficoll density gradient.PBMCs are sti...


US Patent US10399967 (2019)


BindingDB Entry DOI: 10.7270/Q2Z89FRQ
More data for this
Ligand-Target Pair
Interleukin-2


(Homo sapiens (Human))
BDBM412433
PNG
(5-fluoro-N-(4-(2-(6-methoxypyridin- 3-yl)propan-2-...)
Show SMILES COc1ccc(cn1)C(C)(C)c1ccc(NC(=O)c2cncc(F)c2C)cc1
Show InChI InChI=1S/C22H22FN3O2/c1-14-18(12-24-13-19(14)23)21(27)26-17-8-5-15(6-9-17)22(2,3)16-7-10-20(28-4)25-11-16/h5-13H,1-4H3,(H,26,27)
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n/an/a 1.00E+3n/an/an/an/an/an/a



PRCL RESEARCH INC.

US Patent


Assay Description
Human peripheral blood mononuclear cells (PBMCs) are prepared from heparinized human blood by separation over a Ficoll density gradient.PBMCs are sti...


US Patent US10399967 (2019)


BindingDB Entry DOI: 10.7270/Q2Z89FRQ
More data for this
Ligand-Target Pair
Interleukin-2


(Homo sapiens (Human))
BDBM412500
PNG
(5-fluoro-N-(5-(1-(6-hydroxypyridin- 3-yl)-2-methyl...)
Show SMILES CC(C)=C(c1ccc(O)nc1)c1ccc(NC(=O)c2cncc(F)c2C)nc1
Show InChI InChI=1S/C21H19FN4O2/c1-12(2)20(15-5-7-19(27)25-9-15)14-4-6-18(24-8-14)26-21(28)16-10-23-11-17(22)13(16)3/h4-11H,1-3H3,(H,25,27)(H,24,26,28)
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n/an/a 1.00E+3n/an/an/an/an/an/a



PRCL RESEARCH INC.

US Patent


Assay Description
Human peripheral blood mononuclear cells (PBMCs) are prepared from heparinized human blood by separation over a Ficoll density gradient.PBMCs are sti...


US Patent US10399967 (2019)


BindingDB Entry DOI: 10.7270/Q2Z89FRQ
More data for this
Ligand-Target Pair
Interleukin-2


(Homo sapiens (Human))
BDBM412411
PNG
(N-(4-(2-(benzyloxy)pyridin-3- yl)phenyl)-4-methyln...)
Show SMILES Cc1ccncc1C(=O)Nc1ccc(cc1)-c1cccnc1OCc1ccccc1
Show InChI InChI=1S/C25H21N3O2/c1-18-13-15-26-16-23(18)24(29)28-21-11-9-20(10-12-21)22-8-5-14-27-25(22)30-17-19-6-3-2-4-7-19/h2-16H,17H2,1H3,(H,28,29)
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n/an/a 1.00E+3n/an/an/an/an/an/a



PRCL RESEARCH INC.

US Patent


Assay Description
Human peripheral blood mononuclear cells (PBMCs) are prepared from heparinized human blood by separation over a Ficoll density gradient.PBMCs are sti...


US Patent US10399967 (2019)


BindingDB Entry DOI: 10.7270/Q2Z89FRQ
More data for this
Ligand-Target Pair
Interleukin-2


(Homo sapiens (Human))
BDBM412425
PNG
(N-(4-(2-(6-chloropyridin-3- yl)propan-2-yl)phenyl)...)
Show SMILES Cc1c(F)cncc1C(=O)Nc1ccc(cc1)C(C)(C)c1ccc(Cl)nc1
Show InChI InChI=1S/C21H19ClFN3O/c1-13-17(11-24-12-18(13)23)20(27)26-16-7-4-14(5-8-16)21(2,3)15-6-9-19(22)25-10-15/h4-12H,1-3H3,(H,26,27)
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n/an/a 1.00E+3n/an/an/an/an/an/a



PRCL RESEARCH INC.

US Patent


Assay Description
Human peripheral blood mononuclear cells (PBMCs) are prepared from heparinized human blood by separation over a Ficoll density gradient.PBMCs are sti...


US Patent US10399967 (2019)


BindingDB Entry DOI: 10.7270/Q2Z89FRQ
More data for this
Ligand-Target Pair
Interleukin-2


(Homo sapiens (Human))
BDBM412469
PNG
(5-fluoro-N-(6-(1-(4-methoxyphenyl)- 2-methylprop-1...)
Show SMILES COc1ccc(cc1)C(=C(C)C)c1ccc(NC(=O)c2cncc(F)c2C)cn1
Show InChI InChI=1S/C23H22FN3O2/c1-14(2)22(16-5-8-18(29-4)9-6-16)21-10-7-17(11-26-21)27-23(28)19-12-25-13-20(24)15(19)3/h5-13H,1-4H3,(H,27,28)
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n/an/a 1.00E+3n/an/an/an/an/an/a



PRCL RESEARCH INC.

US Patent


Assay Description
Human peripheral blood mononuclear cells (PBMCs) are prepared from heparinized human blood by separation over a Ficoll density gradient.PBMCs are sti...


US Patent US10399967 (2019)


BindingDB Entry DOI: 10.7270/Q2Z89FRQ
More data for this
Ligand-Target Pair
Interleukin-2


(Homo sapiens (Human))
BDBM412434
PNG
(5-fluoro-4-methyl-N-(4-(2-(6- (pyrrolidin-1-yl)pyr...)
Show SMILES Cc1c(F)cncc1C(=O)Nc1ccc(cc1)C(C)(C)c1ccc(nc1)N1CCCC1
Show InChI InChI=1S/C25H27FN4O/c1-17-21(15-27-16-22(17)26)24(31)29-20-9-6-18(7-10-20)25(2,3)19-8-11-23(28-14-19)30-12-4-5-13-30/h6-11,14-16H,4-5,12-13H2,1-3H3,(H,29,31)
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n/an/a 1.00E+3n/an/an/an/an/an/a



PRCL RESEARCH INC.

US Patent


Assay Description
Human peripheral blood mononuclear cells (PBMCs) are prepared from heparinized human blood by separation over a Ficoll density gradient.PBMCs are sti...


US Patent US10399967 (2019)


BindingDB Entry DOI: 10.7270/Q2Z89FRQ
More data for this
Ligand-Target Pair
Interleukin-2


(Homo sapiens (Human))
BDBM412474
PNG
(5-fluoro-N-(5-(1-(4- methoxyphenyl)propyl)pyridin-...)
Show SMILES CCC(c1ccc(OC)cc1)c1ccc(NC(=O)c2cncc(F)c2C)nc1
Show InChI InChI=1S/C22H22FN3O2/c1-4-18(15-5-8-17(28-3)9-6-15)16-7-10-21(25-11-16)26-22(27)19-12-24-13-20(23)14(19)2/h5-13,18H,4H2,1-3H3,(H,25,26,27)
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n/an/a 1.00E+3n/an/an/an/an/an/a



PRCL RESEARCH INC.

US Patent


Assay Description
Human peripheral blood mononuclear cells (PBMCs) are prepared from heparinized human blood by separation over a Ficoll density gradient.PBMCs are sti...


US Patent US10399967 (2019)


BindingDB Entry DOI: 10.7270/Q2Z89FRQ
More data for this
Ligand-Target Pair
Interleukin-2


(Homo sapiens (Human))
BDBM412495
PNG
(5-fluoro-N-(5-(1-hydroxy-1-(4- (methylsulfonyl)phe...)
Show SMILES CCC(O)(c1ccc(cc1)S(C)(=O)=O)c1ccc(NC(=O)c2cncc(F)c2C)nc1
Show InChI InChI=1S/C22H22FN3O4S/c1-4-22(28,15-5-8-17(9-6-15)31(3,29)30)16-7-10-20(25-11-16)26-21(27)18-12-24-13-19(23)14(18)2/h5-13,28H,4H2,1-3H3,(H,25,26,27)
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n/an/a 1.00E+3n/an/an/an/an/an/a



PRCL RESEARCH INC.

US Patent


Assay Description
Human peripheral blood mononuclear cells (PBMCs) are prepared from heparinized human blood by separation over a Ficoll density gradient.PBMCs are sti...


US Patent US10399967 (2019)


BindingDB Entry DOI: 10.7270/Q2Z89FRQ
More data for this
Ligand-Target Pair
Interleukin-2


(Homo sapiens (Human))
BDBM412444
PNG
(5-fluoro-4-methyl-N-(5-(1- phenylcyclopropyl)pyraz...)
Show SMILES Cc1c(F)cncc1C(=O)Nc1cnc(cn1)C1(CC1)c1ccccc1
Show InChI InChI=1S/C20H17FN4O/c1-13-15(9-22-10-16(13)21)19(26)25-18-12-23-17(11-24-18)20(7-8-20)14-5-3-2-4-6-14/h2-6,9-12H,7-8H2,1H3,(H,24,25,26)
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n/an/a 1.00E+3n/an/an/an/an/an/a



PRCL RESEARCH INC.

US Patent


Assay Description
Human peripheral blood mononuclear cells (PBMCs) are prepared from heparinized human blood by separation over a Ficoll density gradient.PBMCs are sti...


US Patent US10399967 (2019)


BindingDB Entry DOI: 10.7270/Q2Z89FRQ
More data for this
Ligand-Target Pair
Interleukin-2


(Homo sapiens (Human))
BDBM412428
PNG
(5-fluoro-N-(4-(1-(4- hydroxyphenyl)cyclopropyl)phe...)
Show SMILES Cc1c(F)cncc1C(=O)Nc1ccc(cc1)C1(CC1)c1ccc(O)cc1
Show InChI InChI=1S/C22H19FN2O2/c1-14-19(12-24-13-20(14)23)21(27)25-17-6-2-15(3-7-17)22(10-11-22)16-4-8-18(26)9-5-16/h2-9,12-13,26H,10-11H2,1H3,(H,25,27)
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n/an/a 1.00E+3n/an/an/an/an/an/a



PRCL RESEARCH INC.

US Patent


Assay Description
Human peripheral blood mononuclear cells (PBMCs) are prepared from heparinized human blood by separation over a Ficoll density gradient.PBMCs are sti...


US Patent US10399967 (2019)


BindingDB Entry DOI: 10.7270/Q2Z89FRQ
More data for this
Ligand-Target Pair
Interleukin-2


(Homo sapiens (Human))
BDBM412409
PNG
(N-(5-(2-cyano-5-(oxetan-3- yloxy)phenyl)pyrazin-2-...)
Show SMILES Cc1ccncc1C(=O)Nc1cnc(cn1)-c1cc(OC2COC2)ccc1C#N
Show InChI InChI=1S/C21H17N5O3/c1-13-4-5-23-8-18(13)21(27)26-20-10-24-19(9-25-20)17-6-15(3-2-14(17)7-22)29-16-11-28-12-16/h2-6,8-10,16H,11-12H2,1H3,(H,25,26,27)
PDB
MMDB

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n/an/a 1.00E+3n/an/an/an/an/an/a



PRCL RESEARCH INC.

US Patent


Assay Description
Human peripheral blood mononuclear cells (PBMCs) are prepared from heparinized human blood by separation over a Ficoll density gradient.PBMCs are sti...


US Patent US10399967 (2019)


BindingDB Entry DOI: 10.7270/Q2Z89FRQ
More data for this
Ligand-Target Pair
Interleukin-2


(Homo sapiens (Human))
BDBM412492
PNG
((Z)-4-(1-(6-(5-fluoro-4- methylnicotinamido)pyridi...)
Show SMILES C\C=C(\c1ccc(cc1)C(O)=O)c1ccc(NC(=O)c2cncc(F)c2C)nc1
Show InChI InChI=1S/C22H18FN3O3/c1-3-17(14-4-6-15(7-5-14)22(28)29)16-8-9-20(25-10-16)26-21(27)18-11-24-12-19(23)13(18)2/h3-12H,1-2H3,(H,28,29)(H,25,26,27)/b17-3-
PDB
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n/an/a 1.00E+3n/an/an/an/an/an/a



PRCL RESEARCH INC.

US Patent


Assay Description
Human peripheral blood mononuclear cells (PBMCs) are prepared from heparinized human blood by separation over a Ficoll density gradient.PBMCs are sti...


US Patent US10399967 (2019)


BindingDB Entry DOI: 10.7270/Q2Z89FRQ
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%