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Patent code US10399987

Compile Data Set for Download or QSAR
Found 98 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
TGF-beta receptor type-1 T204D


(Homo sapiens (Human))
BDBM412768
PNG
(N-(3-fluoropyridin-4-yl)-5-methyl-2-(6-methylpyrid...)
Show SMILES Cc1c[nH]c2nc(nc(Nc3ccncc3F)c12)-c1cccc(C)n1
Show InChI InChI=1S/C18H15FN6/c1-10-8-21-17-15(10)18(23-13-6-7-20-9-12(13)19)25-16(24-17)14-5-3-4-11(2)22-14/h3-9H,1-2H3,(H2,20,21,23,24,25)
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n/an/a 0.25n/an/an/an/an/an/a



Bristol-Myer Squibb Company

US Patent


Assay Description
Assays are conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGFβR1 T204D or HIS-TGFβR2 WT, anti-HIS detec...


US Patent US10399987 (2019)


BindingDB Entry DOI: 10.7270/Q2222X4N
More data for this
Ligand-Target Pair
TGF-beta receptor type-1 T204D


(Homo sapiens (Human))
BDBM412735
PNG
(2-(6-(difluoromethyl)pyridin-2-yl)-N-(3-fluoropyri...)
Show SMILES FC(F)c1cccc(n1)-c1nc(Nc2ccncc2F)c2cc[nH]c2n1
Show InChI InChI=1S/C17H11F3N6/c18-10-8-21-6-5-11(10)24-16-9-4-7-22-15(9)25-17(26-16)13-3-1-2-12(23-13)14(19)20/h1-8,14H,(H2,21,22,24,25,26)
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n/an/a 0.25n/an/an/an/an/an/a



Bristol-Myer Squibb Company

US Patent


Assay Description
Assays are conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGFβR1 T204D or HIS-TGFβR2 WT, anti-HIS detec...


US Patent US10399987 (2019)


BindingDB Entry DOI: 10.7270/Q2222X4N
More data for this
Ligand-Target Pair
TGF-beta receptor type-1 T204D


(Homo sapiens (Human))
BDBM412743
PNG
(N-(3-fluoropyridin-4-yl)-2-(pyridin-2-yl)-7H-pyrro...)
Show SMILES Fc1cnccc1Nc1nc(nc2[nH]ccc12)-c1ccccn1
Show InChI InChI=1S/C16H11FN6/c17-11-9-18-7-5-12(11)21-15-10-4-8-20-14(10)22-16(23-15)13-3-1-2-6-19-13/h1-9H,(H2,18,20,21,22,23)
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Bristol-Myer Squibb Company

US Patent


Assay Description
Assays are conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGFβR1 T204D or HIS-TGFβR2 WT, anti-HIS detec...


US Patent US10399987 (2019)


BindingDB Entry DOI: 10.7270/Q2222X4N
More data for this
Ligand-Target Pair
TGF-beta receptor type-1 T204D


(Homo sapiens (Human))
BDBM412766
PNG
(N-(4-((2-(6-(difluoromethyl)pyridin-2-yl)-7H-pyrro...)
Show SMILES CC(=O)Nc1nccc(Nc2nc(nc3[nH]ccc23)-c2cccc(n2)C(F)F)c1F
Show InChI InChI=1S/C19H14F3N7O/c1-9(30)25-19-14(20)11(6-8-24-19)27-17-10-5-7-23-16(10)28-18(29-17)13-4-2-3-12(26-13)15(21)22/h2-8,15H,1H3,(H3,23,24,25,27,28,29,30)
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Bristol-Myer Squibb Company

US Patent


Assay Description
Assays are conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGFβR1 T204D or HIS-TGFβR2 WT, anti-HIS detec...


US Patent US10399987 (2019)


BindingDB Entry DOI: 10.7270/Q2222X4N
More data for this
Ligand-Target Pair
TGF-beta receptor type-1 T204D


(Homo sapiens (Human))
BDBM412738
PNG
(2-(pyrrolidin-1-yl)-N-(4-((2-(6-(trifluoromethyl)p...)
Show SMILES FC(F)(F)c1cccc(n1)-c1nc(Nc2ccnc(NC(=O)CN3CCCC3)c2)c2cc[nH]c2n1
Show InChI InChI=1S/C23H21F3N8O/c24-23(25,26)17-5-3-4-16(30-17)22-32-20-15(7-9-28-20)21(33-22)29-14-6-8-27-18(12-14)31-19(35)13-34-10-1-2-11-34/h3-9,12H,1-2,10-11,13H2,(H3,27,28,29,31,32,33,35)
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n/an/a 0.420n/an/an/an/an/an/a



Bristol-Myer Squibb Company

US Patent


Assay Description
Assays are conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGFβR1 T204D or HIS-TGFβR2 WT, anti-HIS detec...


US Patent US10399987 (2019)


BindingDB Entry DOI: 10.7270/Q2222X4N
More data for this
Ligand-Target Pair
TGF-beta receptor type-1 T204D


(Homo sapiens (Human))
BDBM412739
PNG
(2-(4-methylpiperazin-1-yl)-N-(4-((2-(6-(trifluorom...)
Show SMILES CN1CCN(CC(=O)Nc2cc(Nc3nc(nc4[nH]ccc34)-c3cccc(n3)C(F)(F)F)ccn2)CC1
Show InChI InChI=1S/C24H24F3N9O/c1-35-9-11-36(12-10-35)14-20(37)32-19-13-15(5-7-28-19)30-22-16-6-8-29-21(16)33-23(34-22)17-3-2-4-18(31-17)24(25,26)27/h2-8,13H,9-12,14H2,1H3,(H3,28,29,30,32,33,34,37)
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n/an/a 0.530n/an/an/an/an/an/a



Bristol-Myer Squibb Company

US Patent


Assay Description
Assays are conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGFβR1 T204D or HIS-TGFβR2 WT, anti-HIS detec...


US Patent US10399987 (2019)


BindingDB Entry DOI: 10.7270/Q2222X4N
More data for this
Ligand-Target Pair
TGF-beta receptor type-1 T204D


(Homo sapiens (Human))
BDBM412745
PNG
(N-(3-fluoropyridin-4-yl)-2-(6-(trifluoromethyl)pyr...)
Show SMILES Fc1cnccc1Nc1nc(nc2[nH]ccc12)-c1cccc(n1)C(F)(F)F
Show InChI InChI=1S/C17H10F4N6/c18-10-8-22-6-5-11(10)25-15-9-4-7-23-14(9)26-16(27-15)12-2-1-3-13(24-12)17(19,20)21/h1-8H,(H2,22,23,25,26,27)
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n/an/a 0.560n/an/an/an/an/an/a



Bristol-Myer Squibb Company

US Patent


Assay Description
Assays are conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGFβR1 T204D or HIS-TGFβR2 WT, anti-HIS detec...


US Patent US10399987 (2019)


BindingDB Entry DOI: 10.7270/Q2222X4N
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
TGF-beta receptor type-1 T204D


(Homo sapiens (Human))
BDBM412773
PNG
(N-methyl-N-{2-[6-(trifluoromethyl)pyridin-2-yl]-7H...)
Show SMILES CN(c1ccncc1)c1nc(nc2[nH]ccc12)-c1cccc(n1)C(F)(F)F
Show InChI InChI=1S/C18H13F3N6/c1-27(11-5-8-22-9-6-11)17-12-7-10-23-15(12)25-16(26-17)13-3-2-4-14(24-13)18(19,20)21/h2-10H,1H3,(H,23,25,26)
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n/an/a 0.590n/an/an/an/an/an/a



Bristol-Myer Squibb Company

US Patent


Assay Description
Assays are conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGFβR1 T204D or HIS-TGFβR2 WT, anti-HIS detec...


US Patent US10399987 (2019)


BindingDB Entry DOI: 10.7270/Q2222X4N
More data for this
Ligand-Target Pair
TGF-beta receptor type-1 T204D


(Homo sapiens (Human))
BDBM412775
PNG
(3-chloro-N-{2-[6-(trifluoromethyl)pyridin-2-yl]-7H...)
Show SMILES FC(F)(F)c1cccc(n1)-c1nc(Nc2ccncc2Cl)c2cc[nH]c2n1
Show InChI InChI=1S/C17H10ClF3N6/c18-10-8-22-6-5-11(10)25-15-9-4-7-23-14(9)26-16(27-15)12-2-1-3-13(24-12)17(19,20)21/h1-8H,(H2,22,23,25,26,27)
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Bristol-Myer Squibb Company

US Patent


Assay Description
Assays are conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGFβR1 T204D or HIS-TGFβR2 WT, anti-HIS detec...


US Patent US10399987 (2019)


BindingDB Entry DOI: 10.7270/Q2222X4N
More data for this
Ligand-Target Pair
TGF-beta receptor type-1 T204D


(Homo sapiens (Human))
BDBM412746
PNG
(2-(5-fluoro-6-methylpyridin-2-yl)-N-(3-fluoropyrid...)
Show SMILES Cc1nc(ccc1F)-c1nc(Nc2ccncc2F)c2cc[nH]c2n1
Show InChI InChI=1S/C17H12F2N6/c1-9-11(18)2-3-14(22-9)17-24-15-10(4-7-21-15)16(25-17)23-13-5-6-20-8-12(13)19/h2-8H,1H3,(H2,20,21,23,24,25)
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n/an/a 0.600n/an/an/an/an/an/a



Bristol-Myer Squibb Company

US Patent


Assay Description
Assays are conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGFβR1 T204D or HIS-TGFβR2 WT, anti-HIS detec...


US Patent US10399987 (2019)


BindingDB Entry DOI: 10.7270/Q2222X4N
More data for this
Ligand-Target Pair
TGF-beta receptor type-1 T204D


(Homo sapiens (Human))
BDBM412774
PNG
(3-(trifluoromethyl)-N-{2-[6-(trifluoromethyl)pyrid...)
Show SMILES FC(F)(F)c1cccc(n1)-c1nc(Nc2ccncc2C(F)(F)F)c2cc[nH]c2n1
Show InChI InChI=1S/C18H10F6N6/c19-17(20,21)10-8-25-6-5-11(10)28-15-9-4-7-26-14(9)29-16(30-15)12-2-1-3-13(27-12)18(22,23)24/h1-8H,(H2,25,26,28,29,30)
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n/an/a 0.640n/an/an/an/an/an/a



Bristol-Myer Squibb Company

US Patent


Assay Description
Assays are conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGFβR1 T204D or HIS-TGFβR2 WT, anti-HIS detec...


US Patent US10399987 (2019)


BindingDB Entry DOI: 10.7270/Q2222X4N
More data for this
Ligand-Target Pair
TGF-beta receptor type-1 T204D


(Homo sapiens (Human))
BDBM412747
PNG
(2-(6-(difluoromethyl)pyridin-2-yl)-4-(1H-pyrrolo[3...)
Show SMILES FC(F)c1cccc(n1)-c1nc(-n2ccc3cnccc23)c2cc[nH]c2n1
Show InChI InChI=1S/C19H12F2N6/c20-16(21)13-2-1-3-14(24-13)18-25-17-12(4-8-23-17)19(26-18)27-9-6-11-10-22-7-5-15(11)27/h1-10,16H,(H,23,25,26)
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Bristol-Myer Squibb Company

US Patent


Assay Description
Assays are conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGFβR1 T204D or HIS-TGFβR2 WT, anti-HIS detec...


US Patent US10399987 (2019)


BindingDB Entry DOI: 10.7270/Q2222X4N
More data for this
Ligand-Target Pair
TGF-beta receptor type-1 T204D


(Homo sapiens (Human))
BDBM412755
PNG
(N-(4-((2-(6-(trifluoromethyl)pyridin-2-yl)-7H-pyrr...)
Show SMILES CC(=O)Nc1cc(Nc2nc(nc3[nH]ccc23)-c2cccc(n2)C(F)(F)F)ccn1
Show InChI InChI=1S/C19H14F3N7O/c1-10(30)25-15-9-11(5-7-23-15)26-17-12-6-8-24-16(12)28-18(29-17)13-3-2-4-14(27-13)19(20,21)22/h2-9H,1H3,(H3,23,24,25,26,28,29,30)
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Bristol-Myer Squibb Company

US Patent


Assay Description
Assays are conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGFβR1 T204D or HIS-TGFβR2 WT, anti-HIS detec...


US Patent US10399987 (2019)


BindingDB Entry DOI: 10.7270/Q2222X4N
More data for this
Ligand-Target Pair
TGF-beta receptor type-1 T204D


(Homo sapiens (Human))
BDBM412734
PNG
(N-(3-fluoropyridin-4-yl)-2-(6-methylpyridin-2-yl)-...)
Show SMILES Cc1cccc(n1)-c1nc(Nc2ccncc2F)c2cc[nH]c2n1
Show InChI InChI=1S/C17H13FN6/c1-10-3-2-4-14(21-10)17-23-15-11(5-8-20-15)16(24-17)22-13-6-7-19-9-12(13)18/h2-9H,1H3,(H2,19,20,22,23,24)
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Bristol-Myer Squibb Company

US Patent


Assay Description
Assays are conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGFβR1 T204D or HIS-TGFβR2 WT, anti-HIS detec...


US Patent US10399987 (2019)


BindingDB Entry DOI: 10.7270/Q2222X4N
More data for this
Ligand-Target Pair
TGF-beta receptor type-1 T204D


(Homo sapiens (Human))
BDBM412751
PNG
(N-(4-((2-(6-(difluoromethyl)pyridin-2-yl)-7H-pyrro...)
Show SMILES CC(=O)Nc1cc(Nc2nc(nc3[nH]ccc23)-c2cccc(n2)C(F)F)c(F)cn1
Show InChI InChI=1S/C19H14F3N7O/c1-9(30)25-15-7-14(11(20)8-24-15)27-18-10-5-6-23-17(10)28-19(29-18)13-4-2-3-12(26-13)16(21)22/h2-8,16H,1H3,(H3,23,24,25,27,28,29,30)
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Bristol-Myer Squibb Company

US Patent


Assay Description
Assays are conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGFβR1 T204D or HIS-TGFβR2 WT, anti-HIS detec...


US Patent US10399987 (2019)


BindingDB Entry DOI: 10.7270/Q2222X4N
More data for this
Ligand-Target Pair
TGF-beta receptor type-1 T204D


(Homo sapiens (Human))
BDBM412759
PNG
(N-(4-((2-(6-(trifluoromethyl)pyridin-2-yl)-7H-pyrr...)
Show SMILES CCC(=O)Nc1cc(Nc2nc(nc3[nH]ccc23)-c2cccc(n2)C(F)(F)F)ccn1
Show InChI InChI=1S/C20H16F3N7O/c1-2-16(31)28-15-10-11(6-8-24-15)26-18-12-7-9-25-17(12)29-19(30-18)13-4-3-5-14(27-13)20(21,22)23/h3-10H,2H2,1H3,(H3,24,25,26,28,29,30,31)
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Bristol-Myer Squibb Company

US Patent


Assay Description
Assays are conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGFβR1 T204D or HIS-TGFβR2 WT, anti-HIS detec...


US Patent US10399987 (2019)


BindingDB Entry DOI: 10.7270/Q2222X4N
More data for this
Ligand-Target Pair
TGF-beta receptor type-1 T204D


(Homo sapiens (Human))
BDBM412778
PNG
(N-[4-({2-[6-(difluoromethyl)pyridin-2-yl]-5-{[(2-h...)
Show SMILES CC(=O)Nc1cc(Nc2nc(nc3[nH]cc(CNCC(C)(C)O)c23)-c2cccc(n2)C(F)F)ccn1
Show InChI InChI=1S/C24H26F2N8O2/c1-13(35)30-18-9-15(7-8-28-18)31-23-19-14(10-27-12-24(2,3)36)11-29-22(19)33-21(34-23)17-6-4-5-16(32-17)20(25)26/h4-9,11,20,27,36H,10,12H2,1-3H3,(H3,28,29,30,31,33,34,35)
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Bristol-Myer Squibb Company

US Patent


Assay Description
Assays are conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGFβR1 T204D or HIS-TGFβR2 WT, anti-HIS detec...


US Patent US10399987 (2019)


BindingDB Entry DOI: 10.7270/Q2222X4N
More data for this
Ligand-Target Pair
TGF-beta receptor type-1 T204D


(Homo sapiens (Human))
BDBM412741
PNG
(2-(6-(difluoromethyl)pyridin-2-yl)-N-(3-fluoropyri...)
Show SMILES Cc1c[nH]c2nc(nc(Nc3ccncc3F)c12)-c1cccc(n1)C(F)F
Show InChI InChI=1S/C18H13F3N6/c1-9-7-23-17-14(9)18(25-11-5-6-22-8-10(11)19)27-16(26-17)13-4-2-3-12(24-13)15(20)21/h2-8,15H,1H3,(H2,22,23,25,26,27)
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Bristol-Myer Squibb Company

US Patent


Assay Description
Assays are conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGFβR1 T204D or HIS-TGFβR2 WT, anti-HIS detec...


US Patent US10399987 (2019)


BindingDB Entry DOI: 10.7270/Q2222X4N
More data for this
Ligand-Target Pair
TGF-beta receptor type-1 T204D


(Homo sapiens (Human))
BDBM412752
PNG
(US10399987, Example 17 | methyl (4-((2-(6-(difluor...)
Show SMILES COC(=O)Nc1cc(Nc2nc(nc3[nH]ccc23)-c2cccc(n2)C(F)F)ccn1
Show InChI InChI=1S/C19H15F2N7O2/c1-30-19(29)26-14-9-10(5-7-22-14)24-17-11-6-8-23-16(11)27-18(28-17)13-4-2-3-12(25-13)15(20)21/h2-9,15H,1H3,(H3,22,23,24,26,27,28,29)
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n/an/a 0.760n/an/an/an/an/an/a



Bristol-Myer Squibb Company

US Patent


Assay Description
Assays are conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGFβR1 T204D or HIS-TGFβR2 WT, anti-HIS detec...


US Patent US10399987 (2019)


BindingDB Entry DOI: 10.7270/Q2222X4N
More data for this
Ligand-Target Pair
TGF-beta receptor type-1 T204D


(Homo sapiens (Human))
BDBM412767
PNG
(2-morpholino-N-(4-((2-(6-(trifluoromethyl)pyridin-...)
Show SMILES FC(F)(F)c1cccc(n1)-c1nc(Nc2ccnc(NC(=O)CN3CCOCC3)c2)c2cc[nH]c2n1
Show InChI InChI=1S/C23H21F3N8O2/c24-23(25,26)17-3-1-2-16(30-17)22-32-20-15(5-7-28-20)21(33-22)29-14-4-6-27-18(12-14)31-19(35)13-34-8-10-36-11-9-34/h1-7,12H,8-11,13H2,(H3,27,28,29,31,32,33,35)
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n/an/a 0.770n/an/an/an/an/an/a



Bristol-Myer Squibb Company

US Patent


Assay Description
Assays are conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGFβR1 T204D or HIS-TGFβR2 WT, anti-HIS detec...


US Patent US10399987 (2019)


BindingDB Entry DOI: 10.7270/Q2222X4N
More data for this
Ligand-Target Pair
TGF-beta receptor type-1 T204D


(Homo sapiens (Human))
BDBM412764
PNG
(N-(4-((2-(5-fluoro-6-methylpyridin-2-yl)-7H-pyrrol...)
Show SMILES CC(=O)Nc1cc(Nc2nc(nc3[nH]ccc23)-c2ccc(F)c(C)n2)ccn1
Show InChI InChI=1S/C19H16FN7O/c1-10-14(20)3-4-15(23-10)19-26-17-13(6-8-22-17)18(27-19)25-12-5-7-21-16(9-12)24-11(2)28/h3-9H,1-2H3,(H3,21,22,24,25,26,27,28)
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n/an/a 0.770n/an/an/an/an/an/a



Bristol-Myer Squibb Company

US Patent


Assay Description
Assays are conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGFβR1 T204D or HIS-TGFβR2 WT, anti-HIS detec...


US Patent US10399987 (2019)


BindingDB Entry DOI: 10.7270/Q2222X4N
More data for this
Ligand-Target Pair
TGF-beta receptor type-1 T204D


(Homo sapiens (Human))
BDBM412736
PNG
(N-(4-((2-(6-(difluoromethyl)pyridin-2-yl)-7H-pyrro...)
Show SMILES CC(=O)Nc1cc(Nc2nc(nc3[nH]ccc23)-c2cccc(n2)C(F)F)ccn1
Show InChI InChI=1S/C19H15F2N7O/c1-10(29)24-15-9-11(5-7-22-15)25-18-12-6-8-23-17(12)27-19(28-18)14-4-2-3-13(26-14)16(20)21/h2-9,16H,1H3,(H3,22,23,24,25,27,28,29)
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n/an/a 0.780n/an/an/an/an/an/a



Bristol-Myer Squibb Company

US Patent


Assay Description
Assays are conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGFβR1 T204D or HIS-TGFβR2 WT, anti-HIS detec...


US Patent US10399987 (2019)


BindingDB Entry DOI: 10.7270/Q2222X4N
More data for this
Ligand-Target Pair
TGF-beta receptor type-1 T204D


(Homo sapiens (Human))
BDBM412781
PNG
(N-[2-(5-fluoro-6-methylpyridin-2-yl)-7H-pyrrolo[2,...)
Show SMILES COc1cnccc1Nc1nc(nc2[nH]ccc12)-c1ccc(F)c(C)n1
Show InChI InChI=1S/C18H15FN6O/c1-10-12(19)3-4-14(22-10)18-24-16-11(5-8-21-16)17(25-18)23-13-6-7-20-9-15(13)26-2/h3-9H,1-2H3,(H2,20,21,23,24,25)
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n/an/a 0.790n/an/an/an/an/an/a



Bristol-Myer Squibb Company

US Patent


Assay Description
Assays are conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGFβR1 T204D or HIS-TGFβR2 WT, anti-HIS detec...


US Patent US10399987 (2019)


BindingDB Entry DOI: 10.7270/Q2222X4N
More data for this
Ligand-Target Pair
TGF-beta receptor type-1 T204D


(Homo sapiens (Human))
BDBM412762
PNG
(3-methyl-N-(4-((2-(6-(trifluoromethyl)pyridin-2-yl...)
Show SMILES CC(C)CC(=O)Nc1cc(Nc2nc(nc3[nH]ccc23)-c2cccc(n2)C(F)(F)F)ccn1
Show InChI InChI=1S/C22H20F3N7O/c1-12(2)10-18(33)30-17-11-13(6-8-26-17)28-20-14-7-9-27-19(14)31-21(32-20)15-4-3-5-16(29-15)22(23,24)25/h3-9,11-12H,10H2,1-2H3,(H3,26,27,28,30,31,32,33)
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n/an/a 0.850n/an/an/an/an/an/a



Bristol-Myer Squibb Company

US Patent


Assay Description
Assays are conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGFβR1 T204D or HIS-TGFβR2 WT, anti-HIS detec...


US Patent US10399987 (2019)


BindingDB Entry DOI: 10.7270/Q2222X4N
More data for this
Ligand-Target Pair
TGF-beta receptor type-1 T204D


(Homo sapiens (Human))
BDBM412776
PNG
(N-[4-({2-[6-(trifluoromethyl)pyridin-2-yl]-7H-pyrr...)
Show SMILES FC(F)(F)c1cccc(n1)-c1nc(Nc2ccnc(NC(=O)C3CC3)c2)c2cc[nH]c2n1
Show InChI InChI=1S/C21H16F3N7O/c22-21(23,24)15-3-1-2-14(28-15)19-30-17-13(7-9-26-17)18(31-19)27-12-6-8-25-16(10-12)29-20(32)11-4-5-11/h1-3,6-11H,4-5H2,(H3,25,26,27,29,30,31,32)
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n/an/a 0.870n/an/an/an/an/an/a



Bristol-Myer Squibb Company

US Patent


Assay Description
Assays are conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGFβR1 T204D or HIS-TGFβR2 WT, anti-HIS detec...


US Patent US10399987 (2019)


BindingDB Entry DOI: 10.7270/Q2222X4N
More data for this
Ligand-Target Pair
TGF-beta receptor type-1 T204D


(Homo sapiens (Human))
BDBM412772
PNG
(3-methyl-N-{2-[6-(trifluoromethyl)pyridin-2-yl]-7H...)
Show SMILES Cc1cnccc1Nc1nc(nc2[nH]ccc12)-c1cccc(n1)C(F)(F)F
Show InChI InChI=1S/C18H13F3N6/c1-10-9-22-7-6-12(10)25-16-11-5-8-23-15(11)26-17(27-16)13-3-2-4-14(24-13)18(19,20)21/h2-9H,1H3,(H2,22,23,25,26,27)
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n/an/a 0.870n/an/an/an/an/an/a



Bristol-Myer Squibb Company

US Patent


Assay Description
Assays are conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGFβR1 T204D or HIS-TGFβR2 WT, anti-HIS detec...


US Patent US10399987 (2019)


BindingDB Entry DOI: 10.7270/Q2222X4N
More data for this
Ligand-Target Pair
TGF-beta receptor type-1 T204D


(Homo sapiens (Human))
BDBM412756
PNG
(N-(4-((2-(pyridin-2-yl)-7H-pyrrolo[2,3-d]pyrimidin...)
Show SMILES CC(=O)Nc1cc(Nc2nc(nc3[nH]ccc23)-c2ccccn2)ccn1
Show InChI InChI=1S/C18H15N7O/c1-11(26)22-15-10-12(5-8-20-15)23-17-13-6-9-21-16(13)24-18(25-17)14-4-2-3-7-19-14/h2-10H,1H3,(H3,20,21,22,23,24,25,26)
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Bristol-Myer Squibb Company

US Patent


Assay Description
Assays are conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGFβR1 T204D or HIS-TGFβR2 WT, anti-HIS detec...


US Patent US10399987 (2019)


BindingDB Entry DOI: 10.7270/Q2222X4N
More data for this
Ligand-Target Pair
TGF-beta receptor type-1 T204D


(Homo sapiens (Human))
BDBM412749
PNG
(2-(5-fluoropyridin-2-yl)-N-(3-fluoropyridin-4-yl)-...)
Show SMILES Fc1ccc(nc1)-c1nc(Nc2ccncc2F)c2cc[nH]c2n1
Show InChI InChI=1S/C16H10F2N6/c17-9-1-2-13(21-7-9)16-23-14-10(3-6-20-14)15(24-16)22-12-4-5-19-8-11(12)18/h1-8H,(H2,19,20,22,23,24)
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n/an/a 0.910n/an/an/an/an/an/a



Bristol-Myer Squibb Company

US Patent


Assay Description
Assays are conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGFβR1 T204D or HIS-TGFβR2 WT, anti-HIS detec...


US Patent US10399987 (2019)


BindingDB Entry DOI: 10.7270/Q2222X4N
More data for this
Ligand-Target Pair
TGF-beta receptor type-1 T204D


(Homo sapiens (Human))
BDBM412757
PNG
(N-(4-((2-(6-methylpyridin-2-yl)-7H-pyrrolo[2,3-d]p...)
Show SMILES CC(=O)Nc1cc(Nc2nc(nc3[nH]ccc23)-c2cccc(C)n2)ccn1
Show InChI InChI=1S/C19H17N7O/c1-11-4-3-5-15(22-11)19-25-17-14(7-9-21-17)18(26-19)24-13-6-8-20-16(10-13)23-12(2)27/h3-10H,1-2H3,(H3,20,21,23,24,25,26,27)
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n/an/a 1n/an/an/an/an/an/a



Bristol-Myer Squibb Company

US Patent


Assay Description
Assays are conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGFβR1 T204D or HIS-TGFβR2 WT, anti-HIS detec...


US Patent US10399987 (2019)


BindingDB Entry DOI: 10.7270/Q2222X4N
More data for this
Ligand-Target Pair
TGF-beta receptor type-1 T204D


(Homo sapiens (Human))
BDBM412780
PNG
(N-[2-(5-fluoro-6-methylpyridin-2-yl)-7H-pyrrolo[2,...)
Show SMILES Cc1cnccc1Nc1nc(nc2[nH]ccc12)-c1ccc(F)c(C)n1
Show InChI InChI=1S/C18H15FN6/c1-10-9-20-7-6-14(10)23-17-12-5-8-21-16(12)24-18(25-17)15-4-3-13(19)11(2)22-15/h3-9H,1-2H3,(H2,20,21,23,24,25)
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n/an/a 1n/an/an/an/an/an/a



Bristol-Myer Squibb Company

US Patent


Assay Description
Assays are conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGFβR1 T204D or HIS-TGFβR2 WT, anti-HIS detec...


US Patent US10399987 (2019)


BindingDB Entry DOI: 10.7270/Q2222X4N
More data for this
Ligand-Target Pair
TGF-beta receptor type-1 T204D


(Homo sapiens (Human))
BDBM412744
PNG
(2-(pyridin-2-yl)-4-(1H-pyrrolo[3,2-c]pyridin-1-yl)...)
Show SMILES c1cc2c(nc(nc2[nH]1)-c1ccccn1)-n1ccc2cnccc12
Show InChI InChI=1S/C18H12N6/c1-2-7-20-14(3-1)17-22-16-13(4-9-21-16)18(23-17)24-10-6-12-11-19-8-5-15(12)24/h1-11H,(H,21,22,23)
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n/an/a 1.20n/an/an/an/an/an/a



Bristol-Myer Squibb Company

US Patent


Assay Description
Assays are conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGFβR1 T204D or HIS-TGFβR2 WT, anti-HIS detec...


US Patent US10399987 (2019)


BindingDB Entry DOI: 10.7270/Q2222X4N
More data for this
Ligand-Target Pair
TGF-beta receptor type-1 T204D


(Homo sapiens (Human))
BDBM412753
PNG
(N-(5-fluoro-4-((2-(5-fluoro-6-methylpyridin-2-yl)-...)
Show SMILES CC(=O)Nc1cc(Nc2nc(nc3[nH]ccc23)-c2ccc(F)c(n2)C(F)F)c(F)cn1
Show InChI InChI=1S/C19H13F4N7O/c1-8(31)26-14-6-13(11(21)7-25-14)28-18-9-4-5-24-17(9)29-19(30-18)12-3-2-10(20)15(27-12)16(22)23/h2-7,16H,1H3,(H3,24,25,26,28,29,30,31)
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n/an/a 1.30n/an/an/an/an/an/a



Bristol-Myer Squibb Company

US Patent


Assay Description
Assays are conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGFβR1 T204D or HIS-TGFβR2 WT, anti-HIS detec...


US Patent US10399987 (2019)


BindingDB Entry DOI: 10.7270/Q2222X4N
More data for this
Ligand-Target Pair
TGF-beta receptor type-1 T204D


(Homo sapiens (Human))
BDBM412782
PNG
(N-(4-{[2-(5-fluoro-6-methylpyridin-2-yl)-7H-pyrrol...)
Show SMILES Cc1nc(ccc1F)-c1nc(Nc2ccnc(NC(=O)C3CC3)c2)c2cc[nH]c2n1
Show InChI InChI=1S/C21H18FN7O/c1-11-15(22)4-5-16(25-11)20-28-18-14(7-9-24-18)19(29-20)26-13-6-8-23-17(10-13)27-21(30)12-2-3-12/h4-10,12H,2-3H2,1H3,(H3,23,24,26,27,28,29,30)
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n/an/a 1.40n/an/an/an/an/an/a



Bristol-Myer Squibb Company

US Patent


Assay Description
Assays are conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGFβR1 T204D or HIS-TGFβR2 WT, anti-HIS detec...


US Patent US10399987 (2019)


BindingDB Entry DOI: 10.7270/Q2222X4N
More data for this
Ligand-Target Pair
TGF-beta receptor type-1 T204D


(Homo sapiens (Human))
BDBM412770
PNG
(1-(((2-(6-(difluoromethyl)pyridin-2-yl)-4-((3-fluo...)
Show SMILES CC(C)(O)CNCc1c[nH]c2nc(nc(Nc3ccncc3F)c12)-c1cccc(n1)C(F)F
Show InChI InChI=1S/C22H22F3N7O/c1-22(2,33)11-27-8-12-9-28-20-17(12)21(30-14-6-7-26-10-13(14)23)32-19(31-20)16-5-3-4-15(29-16)18(24)25/h3-7,9-10,18,27,33H,8,11H2,1-2H3,(H2,26,28,30,31,32)
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n/an/a 1.40n/an/an/an/an/an/a



Bristol-Myer Squibb Company

US Patent


Assay Description
Assays are conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGFβR1 T204D or HIS-TGFβR2 WT, anti-HIS detec...


US Patent US10399987 (2019)


BindingDB Entry DOI: 10.7270/Q2222X4N
More data for this
Ligand-Target Pair
TGF-beta receptor type-1 T204D


(Homo sapiens (Human))
BDBM412760
PNG
(N-(4-((2-(6-(difluoromethyl)pyridin-2-yl)-5-methyl...)
Show SMILES CC(=O)Nc1cc(Nc2nc(nc3[nH]cc(C)c23)-c2cccc(n2)C(F)F)ccn1
Show InChI InChI=1S/C20H17F2N7O/c1-10-9-24-19-16(10)20(26-12-6-7-23-15(8-12)25-11(2)30)29-18(28-19)14-5-3-4-13(27-14)17(21)22/h3-9,17H,1-2H3,(H3,23,24,25,26,28,29,30)
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Bristol-Myer Squibb Company

US Patent


Assay Description
Assays are conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGFβR1 T204D or HIS-TGFβR2 WT, anti-HIS detec...


US Patent US10399987 (2019)


BindingDB Entry DOI: 10.7270/Q2222X4N
More data for this
Ligand-Target Pair
TGF-beta receptor type-1 T204D


(Homo sapiens (Human))
BDBM412777
PNG
(3-methoxy-N-{2-[6-(trifluoromethyl)pyridin-2-yl]-7...)
Show SMILES COc1cnccc1Nc1nc(nc2[nH]ccc12)-c1cccc(n1)C(F)(F)F
Show InChI InChI=1S/C18H13F3N6O/c1-28-13-9-22-7-6-11(13)25-16-10-5-8-23-15(10)26-17(27-16)12-3-2-4-14(24-12)18(19,20)21/h2-9H,1H3,(H2,22,23,25,26,27)
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Bristol-Myer Squibb Company

US Patent


Assay Description
Assays are conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGFβR1 T204D or HIS-TGFβR2 WT, anti-HIS detec...


US Patent US10399987 (2019)


BindingDB Entry DOI: 10.7270/Q2222X4N
More data for this
Ligand-Target Pair
TGF-beta receptor type-1 T204D


(Homo sapiens (Human))
BDBM412771
PNG
(N-[3-fluoro-4-({2-[6-(trifluoromethyl)pyridin-2-yl...)
Show SMILES CC(=O)Nc1nccc(Nc2nc(nc3[nH]ccc23)-c2cccc(n2)C(F)(F)F)c1F
Show InChI InChI=1S/C19H13F4N7O/c1-9(31)26-18-14(20)11(6-8-25-18)28-16-10-5-7-24-15(10)29-17(30-16)12-3-2-4-13(27-12)19(21,22)23/h2-8H,1H3,(H3,24,25,26,28,29,30,31)
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Bristol-Myer Squibb Company

US Patent


Assay Description
Assays are conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGFβR1 T204D or HIS-TGFβR2 WT, anti-HIS detec...


US Patent US10399987 (2019)


BindingDB Entry DOI: 10.7270/Q2222X4N
More data for this
Ligand-Target Pair
TGF-beta receptor type-1 T204D


(Homo sapiens (Human))
BDBM412784
PNG
(N-(6-{4-[(3-chloropyridin-4-yl)amino]-7H-pyrrolo[2...)
Show SMILES CS(=O)(=O)Nc1cccc(n1)-c1nc(Nc2ccncc2Cl)c2cc[nH]c2n1
Show InChI InChI=1S/C17H14ClN7O2S/c1-28(26,27)25-14-4-2-3-13(21-14)17-23-15-10(5-8-20-15)16(24-17)22-12-6-7-19-9-11(12)18/h2-9H,1H3,(H,21,25)(H2,19,20,22,23,24)
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Bristol-Myer Squibb Company

US Patent


Assay Description
Assays are conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGFβR1 T204D or HIS-TGFβR2 WT, anti-HIS detec...


US Patent US10399987 (2019)


BindingDB Entry DOI: 10.7270/Q2222X4N
More data for this
Ligand-Target Pair
TGF-beta receptor type-1 T204D


(Homo sapiens (Human))
BDBM412765
PNG
(US10399987, Example 30 | methyl (4-((2-(6-(trifluo...)
Show SMILES COC(=O)Nc1cc(Nc2nc(nc3[nH]ccc23)-c2cccc(n2)C(F)(F)F)ccn1
Show InChI InChI=1S/C19H14F3N7O2/c1-31-18(30)27-14-9-10(5-7-23-14)25-16-11-6-8-24-15(11)28-17(29-16)12-3-2-4-13(26-12)19(20,21)22/h2-9H,1H3,(H3,23,24,25,27,28,29,30)
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Bristol-Myer Squibb Company

US Patent


Assay Description
Assays are conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGFβR1 T204D or HIS-TGFβR2 WT, anti-HIS detec...


US Patent US10399987 (2019)


BindingDB Entry DOI: 10.7270/Q2222X4N
More data for this
Ligand-Target Pair
TGF-beta receptor type-1 T204D


(Homo sapiens (Human))
BDBM412779
PNG
(N-[4-({2-[6-(difluoromethyl)pyridin-2-yl]-5-{[(2-h...)
Show SMILES CC(=O)Nc1cc(Nc2nc(nc3[nH]cc(CNCC(C)(C)O)c23)-c2cccc(n2)C(F)F)c(F)cn1
Show InChI InChI=1S/C24H25F3N8O2/c1-12(36)31-18-7-17(14(25)10-29-18)33-23-19-13(8-28-11-24(2,3)37)9-30-22(19)34-21(35-23)16-6-4-5-15(32-16)20(26)27/h4-7,9-10,20,28,37H,8,11H2,1-3H3,(H3,29,30,31,33,34,35,36)
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n/an/a 2.60n/an/an/an/an/an/a



Bristol-Myer Squibb Company

US Patent


Assay Description
Assays are conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGFβR1 T204D or HIS-TGFβR2 WT, anti-HIS detec...


US Patent US10399987 (2019)


BindingDB Entry DOI: 10.7270/Q2222X4N
More data for this
Ligand-Target Pair
TGF-beta receptor type-1 T204D


(Homo sapiens (Human))
BDBM412761
PNG
(3,3-dimethyl-N-(4-((2-(6-(trifluoromethyl)pyridin-...)
Show SMILES CC(C)(C)CC(=O)Nc1cc(Nc2nc(nc3[nH]ccc23)-c2cccc(n2)C(F)(F)F)ccn1
Show InChI InChI=1S/C23H22F3N7O/c1-22(2,3)12-18(34)31-17-11-13(7-9-27-17)29-20-14-8-10-28-19(14)32-21(33-20)15-5-4-6-16(30-15)23(24,25)26/h4-11H,12H2,1-3H3,(H3,27,28,29,31,32,33,34)
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n/an/a 2.70n/an/an/an/an/an/a



Bristol-Myer Squibb Company

US Patent


Assay Description
Assays are conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGFβR1 T204D or HIS-TGFβR2 WT, anti-HIS detec...


US Patent US10399987 (2019)


BindingDB Entry DOI: 10.7270/Q2222X4N
More data for this
Ligand-Target Pair
TGF-beta receptor type-1 T204D


(Homo sapiens (Human))
BDBM412742
PNG
(2-(6-(difluoromethyl)pyridin-2-yl)-N-(3-fluoropyri...)
Show SMILES CN1CCN(Cc2c[nH]c3nc(nc(Nc4ccncc4F)c23)-c2cccc(n2)C(F)F)CC1
Show InChI InChI=1S/C23H23F3N8/c1-33-7-9-34(10-8-33)13-14-11-28-22-19(14)23(30-16-5-6-27-12-15(16)24)32-21(31-22)18-4-2-3-17(29-18)20(25)26/h2-6,11-12,20H,7-10,13H2,1H3,(H2,27,28,30,31,32)
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n/an/a 3.70n/an/an/an/an/an/a



Bristol-Myer Squibb Company

US Patent


Assay Description
Assays are conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGFβR1 T204D or HIS-TGFβR2 WT, anti-HIS detec...


US Patent US10399987 (2019)


BindingDB Entry DOI: 10.7270/Q2222X4N
More data for this
Ligand-Target Pair
TGF-beta receptor type-1 T204D


(Homo sapiens (Human))
BDBM412748
PNG
(N-(2-chloro-5-fluoropyridin-4-yl)-2-(5-fluoro-6-me...)
Show SMILES Cc1nc(ccc1F)-c1nc(Nc2cc(Cl)ncc2F)c2cc[nH]c2n1
Show InChI InChI=1S/C17H11ClF2N6/c1-8-10(19)2-3-12(23-8)17-25-15-9(4-5-21-15)16(26-17)24-13-6-14(18)22-7-11(13)20/h2-7H,1H3,(H2,21,22,24,25,26)
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n/an/a 4n/an/an/an/an/an/a



Bristol-Myer Squibb Company

US Patent


Assay Description
Assays are conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGFβR1 T204D or HIS-TGFβR2 WT, anti-HIS detec...


US Patent US10399987 (2019)


BindingDB Entry DOI: 10.7270/Q2222X4N
More data for this
Ligand-Target Pair
TGF-beta receptor type-1 T204D


(Homo sapiens (Human))
BDBM412783
PNG
(N-(6-{4-[methyl(pyridin-4-yl)amino]-7H-pyrrolo[2,3...)
Show SMILES CN(c1ccncc1)c1nc(nc2[nH]ccc12)-c1cccc(NS(C)(=O)=O)n1
Show InChI InChI=1S/C18H17N7O2S/c1-25(12-6-9-19-10-7-12)18-13-8-11-20-16(13)22-17(23-18)14-4-3-5-15(21-14)24-28(2,26)27/h3-11H,1-2H3,(H,21,24)(H,20,22,23)
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n/an/a 4.30n/an/an/an/an/an/a



Bristol-Myer Squibb Company

US Patent


Assay Description
Assays are conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGFβR1 T204D or HIS-TGFβR2 WT, anti-HIS detec...


US Patent US10399987 (2019)


BindingDB Entry DOI: 10.7270/Q2222X4N
More data for this
Ligand-Target Pair
TGF-beta receptor type-1 T204D


(Homo sapiens (Human))
BDBM412769
PNG
(N-(3-fluoropyridin-4-yl)-5-methyl-2-(6-(trifluorom...)
Show SMILES Cc1c[nH]c2nc(nc(Nc3ccncc3F)c12)-c1cccc(n1)C(F)(F)F
Show InChI InChI=1S/C18H12F4N6/c1-9-7-24-16-14(9)17(26-11-5-6-23-8-10(11)19)28-15(27-16)12-3-2-4-13(25-12)18(20,21)22/h2-8H,1H3,(H2,23,24,26,27,28)
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n/an/a 4.5n/an/an/an/an/an/a



Bristol-Myer Squibb Company

US Patent


Assay Description
Assays are conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGFβR1 T204D or HIS-TGFβR2 WT, anti-HIS detec...


US Patent US10399987 (2019)


BindingDB Entry DOI: 10.7270/Q2222X4N
More data for this
Ligand-Target Pair
TGF-beta receptor type-1 T204D


(Homo sapiens (Human))
BDBM412758
PNG
(N-(4-((2-(5-(trifluoromethyl)pyridin-2-yl)-7H-pyrr...)
Show SMILES CC(=O)Nc1cc(Nc2nc(nc3[nH]ccc23)-c2ccc(cn2)C(F)(F)F)ccn1
Show InChI InChI=1S/C19H14F3N7O/c1-10(30)26-15-8-12(4-6-23-15)27-17-13-5-7-24-16(13)28-18(29-17)14-3-2-11(9-25-14)19(20,21)22/h2-9H,1H3,(H3,23,24,26,27,28,29,30)
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n/an/a 4.70n/an/an/an/an/an/a



Bristol-Myer Squibb Company

US Patent


Assay Description
Assays are conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGFβR1 T204D or HIS-TGFβR2 WT, anti-HIS detec...


US Patent US10399987 (2019)


BindingDB Entry DOI: 10.7270/Q2222X4N
More data for this
Ligand-Target Pair
TGF-beta receptor type-1 T204D


(Homo sapiens (Human))
BDBM412754
PNG
(1-(4-((2-(6-(difluoromethyl)pyridin-2-yl)-7H-pyrro...)
Show SMILES FC(F)c1cccc(n1)-c1nc(Nc2ccnc(c2)N2CCCC2=O)c2cc[nH]c2n1
Show InChI InChI=1S/C21H17F2N7O/c22-18(23)14-3-1-4-15(27-14)21-28-19-13(7-9-25-19)20(29-21)26-12-6-8-24-16(11-12)30-10-2-5-17(30)31/h1,3-4,6-9,11,18H,2,5,10H2,(H2,24,25,26,28,29)
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n/an/a 5.80n/an/an/an/an/an/a



Bristol-Myer Squibb Company

US Patent


Assay Description
Assays are conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGFβR1 T204D or HIS-TGFβR2 WT, anti-HIS detec...


US Patent US10399987 (2019)


BindingDB Entry DOI: 10.7270/Q2222X4N
More data for this
Ligand-Target Pair
TGF-beta receptor type II


(Homo sapiens (Human))
BDBM412782
PNG
(N-(4-{[2-(5-fluoro-6-methylpyridin-2-yl)-7H-pyrrol...)
Show SMILES Cc1nc(ccc1F)-c1nc(Nc2ccnc(NC(=O)C3CC3)c2)c2cc[nH]c2n1
Show InChI InChI=1S/C21H18FN7O/c1-11-15(22)4-5-16(25-11)20-28-18-14(7-9-24-18)19(29-20)26-13-6-8-23-17(10-13)27-21(30)12-2-3-12/h4-10,12H,2-3H2,1H3,(H3,23,24,26,27,28,29,30)
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n/an/a 26n/an/an/an/an/an/a



Bristol-Myer Squibb Company

US Patent


Assay Description
Assays are conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGFβR1 T204D or HIS-TGFβR2 WT, anti-HIS detec...


US Patent US10399987 (2019)


BindingDB Entry DOI: 10.7270/Q2222X4N
More data for this
Ligand-Target Pair
TGF-beta receptor type II


(Homo sapiens (Human))
BDBM412756
PNG
(N-(4-((2-(pyridin-2-yl)-7H-pyrrolo[2,3-d]pyrimidin...)
Show SMILES CC(=O)Nc1cc(Nc2nc(nc3[nH]ccc23)-c2ccccn2)ccn1
Show InChI InChI=1S/C18H15N7O/c1-11(26)22-15-10-12(5-8-20-15)23-17-13-6-9-21-16(13)24-18(25-17)14-4-2-3-7-19-14/h2-10H,1H3,(H3,20,21,22,23,24,25,26)
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n/an/a 50n/an/an/an/an/an/a



Bristol-Myer Squibb Company

US Patent


Assay Description
Assays are conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGFβR1 T204D or HIS-TGFβR2 WT, anti-HIS detec...


US Patent US10399987 (2019)


BindingDB Entry DOI: 10.7270/Q2222X4N
More data for this
Ligand-Target Pair
TGF-beta receptor type II


(Homo sapiens (Human))
BDBM412752
PNG
(US10399987, Example 17 | methyl (4-((2-(6-(difluor...)
Show SMILES COC(=O)Nc1cc(Nc2nc(nc3[nH]ccc23)-c2cccc(n2)C(F)F)ccn1
Show InChI InChI=1S/C19H15F2N7O2/c1-30-19(29)26-14-9-10(5-7-22-14)24-17-11-6-8-23-16(11)27-18(28-17)13-4-2-3-12(25-13)15(20)21/h2-9,15H,1H3,(H3,22,23,24,26,27,28,29)
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n/an/a 100n/an/an/an/an/an/a



Bristol-Myer Squibb Company

US Patent


Assay Description
Assays are conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGFβR1 T204D or HIS-TGFβR2 WT, anti-HIS detec...


US Patent US10399987 (2019)


BindingDB Entry DOI: 10.7270/Q2222X4N
More data for this
Ligand-Target Pair
TGF-beta receptor type II


(Homo sapiens (Human))
BDBM412743
PNG
(N-(3-fluoropyridin-4-yl)-2-(pyridin-2-yl)-7H-pyrro...)
Show SMILES Fc1cnccc1Nc1nc(nc2[nH]ccc12)-c1ccccn1
Show InChI InChI=1S/C16H11FN6/c17-11-9-18-7-5-12(11)21-15-10-4-8-20-14(10)22-16(23-15)13-3-1-2-6-19-13/h1-9H,(H2,18,20,21,22,23)
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n/an/a 150n/an/an/an/an/an/a



Bristol-Myer Squibb Company

US Patent


Assay Description
Assays are conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGFβR1 T204D or HIS-TGFβR2 WT, anti-HIS detec...


US Patent US10399987 (2019)


BindingDB Entry DOI: 10.7270/Q2222X4N
More data for this
Ligand-Target Pair
TGF-beta receptor type II


(Homo sapiens (Human))
BDBM412744
PNG
(2-(pyridin-2-yl)-4-(1H-pyrrolo[3,2-c]pyridin-1-yl)...)
Show SMILES c1cc2c(nc(nc2[nH]1)-c1ccccn1)-n1ccc2cnccc12
Show InChI InChI=1S/C18H12N6/c1-2-7-20-14(3-1)17-22-16-13(4-9-21-16)18(23-17)24-10-6-12-11-19-8-5-15(12)24/h1-11H,(H,21,22,23)
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n/an/a 150n/an/an/an/an/an/a



Bristol-Myer Squibb Company

US Patent


Assay Description
Assays are conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGFβR1 T204D or HIS-TGFβR2 WT, anti-HIS detec...


US Patent US10399987 (2019)


BindingDB Entry DOI: 10.7270/Q2222X4N
More data for this
Ligand-Target Pair
TGF-beta receptor type-1 T204D


(Homo sapiens (Human))
BDBM412750
PNG
(N-(2-chloropyrimidin-4-yl)-2-(6-(difluoromethyl)py...)
Show SMILES FC(F)c1cccc(n1)-c1nc(Nc2ccnc(Cl)n2)c2cc[nH]c2n1
Show InChI InChI=1S/C16H10ClF2N7/c17-16-21-7-5-11(24-16)23-14-8-4-6-20-13(8)25-15(26-14)10-3-1-2-9(22-10)12(18)19/h1-7,12H,(H2,20,21,23,24,25,26)
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n/an/a 160n/an/an/an/an/an/a



Bristol-Myer Squibb Company

US Patent


Assay Description
Assays are conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGFβR1 T204D or HIS-TGFβR2 WT, anti-HIS detec...


US Patent US10399987 (2019)


BindingDB Entry DOI: 10.7270/Q2222X4N
More data for this
Ligand-Target Pair
TGF-beta receptor type II


(Homo sapiens (Human))
BDBM412746
PNG
(2-(5-fluoro-6-methylpyridin-2-yl)-N-(3-fluoropyrid...)
Show SMILES Cc1nc(ccc1F)-c1nc(Nc2ccncc2F)c2cc[nH]c2n1
Show InChI InChI=1S/C17H12F2N6/c1-9-11(18)2-3-14(22-9)17-24-15-10(4-7-21-15)16(25-17)23-13-5-6-20-8-12(13)19/h2-8H,1H3,(H2,20,21,23,24,25)
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n/an/a 170n/an/an/an/an/an/a



Bristol-Myer Squibb Company

US Patent


Assay Description
Assays are conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGFβR1 T204D or HIS-TGFβR2 WT, anti-HIS detec...


US Patent US10399987 (2019)


BindingDB Entry DOI: 10.7270/Q2222X4N
More data for this
Ligand-Target Pair
TGF-beta receptor type II


(Homo sapiens (Human))
BDBM412764
PNG
(N-(4-((2-(5-fluoro-6-methylpyridin-2-yl)-7H-pyrrol...)
Show SMILES CC(=O)Nc1cc(Nc2nc(nc3[nH]ccc23)-c2ccc(F)c(C)n2)ccn1
Show InChI InChI=1S/C19H16FN7O/c1-10-14(20)3-4-15(23-10)19-26-17-13(6-8-22-17)18(27-19)25-12-5-7-21-16(9-12)24-11(2)28/h3-9H,1-2H3,(H3,21,22,24,25,26,27,28)
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n/an/a 190n/an/an/an/an/an/a



Bristol-Myer Squibb Company

US Patent


Assay Description
Assays are conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGFβR1 T204D or HIS-TGFβR2 WT, anti-HIS detec...


US Patent US10399987 (2019)


BindingDB Entry DOI: 10.7270/Q2222X4N
More data for this
Ligand-Target Pair
TGF-beta receptor type II


(Homo sapiens (Human))
BDBM412736
PNG
(N-(4-((2-(6-(difluoromethyl)pyridin-2-yl)-7H-pyrro...)
Show SMILES CC(=O)Nc1cc(Nc2nc(nc3[nH]ccc23)-c2cccc(n2)C(F)F)ccn1
Show InChI InChI=1S/C19H15F2N7O/c1-10(29)24-15-9-11(5-7-22-15)25-18-12-6-8-23-17(12)27-19(28-18)14-4-2-3-13(26-14)16(20)21/h2-9,16H,1H3,(H3,22,23,24,25,27,28,29)
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n/an/a 190n/an/an/an/an/an/a



Bristol-Myer Squibb Company

US Patent


Assay Description
Assays are conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGFβR1 T204D or HIS-TGFβR2 WT, anti-HIS detec...


US Patent US10399987 (2019)


BindingDB Entry DOI: 10.7270/Q2222X4N
More data for this
Ligand-Target Pair
TGF-beta receptor type II


(Homo sapiens (Human))
BDBM412757
PNG
(N-(4-((2-(6-methylpyridin-2-yl)-7H-pyrrolo[2,3-d]p...)
Show SMILES CC(=O)Nc1cc(Nc2nc(nc3[nH]ccc23)-c2cccc(C)n2)ccn1
Show InChI InChI=1S/C19H17N7O/c1-11-4-3-5-15(22-11)19-25-17-14(7-9-21-17)18(26-19)24-13-6-8-20-16(10-13)23-12(2)27/h3-10H,1-2H3,(H3,20,21,23,24,25,26,27)
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n/an/a 230n/an/an/an/an/an/a



Bristol-Myer Squibb Company

US Patent


Assay Description
Assays are conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGFβR1 T204D or HIS-TGFβR2 WT, anti-HIS detec...


US Patent US10399987 (2019)


BindingDB Entry DOI: 10.7270/Q2222X4N
More data for this
Ligand-Target Pair
TGF-beta receptor type II


(Homo sapiens (Human))
BDBM412776
PNG
(N-[4-({2-[6-(trifluoromethyl)pyridin-2-yl]-7H-pyrr...)
Show SMILES FC(F)(F)c1cccc(n1)-c1nc(Nc2ccnc(NC(=O)C3CC3)c2)c2cc[nH]c2n1
Show InChI InChI=1S/C21H16F3N7O/c22-21(23,24)15-3-1-2-14(28-15)19-30-17-13(7-9-26-17)18(31-19)27-12-6-8-25-16(10-12)29-20(32)11-4-5-11/h1-3,6-11H,4-5H2,(H3,25,26,27,29,30,31,32)
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n/an/a 230n/an/an/an/an/an/a



Bristol-Myer Squibb Company

US Patent


Assay Description
Assays are conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGFβR1 T204D or HIS-TGFβR2 WT, anti-HIS detec...


US Patent US10399987 (2019)


BindingDB Entry DOI: 10.7270/Q2222X4N
More data for this
Ligand-Target Pair
TGF-beta receptor type II


(Homo sapiens (Human))
BDBM412749
PNG
(2-(5-fluoropyridin-2-yl)-N-(3-fluoropyridin-4-yl)-...)
Show SMILES Fc1ccc(nc1)-c1nc(Nc2ccncc2F)c2cc[nH]c2n1
Show InChI InChI=1S/C16H10F2N6/c17-9-1-2-13(21-7-9)16-23-14-10(3-6-20-14)15(24-16)22-12-4-5-19-8-11(12)18/h1-8H,(H2,19,20,22,23,24)
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n/an/a 240n/an/an/an/an/an/a



Bristol-Myer Squibb Company

US Patent


Assay Description
Assays are conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGFβR1 T204D or HIS-TGFβR2 WT, anti-HIS detec...


US Patent US10399987 (2019)


BindingDB Entry DOI: 10.7270/Q2222X4N
More data for this
Ligand-Target Pair
TGF-beta receptor type II


(Homo sapiens (Human))
BDBM412734
PNG
(N-(3-fluoropyridin-4-yl)-2-(6-methylpyridin-2-yl)-...)
Show SMILES Cc1cccc(n1)-c1nc(Nc2ccncc2F)c2cc[nH]c2n1
Show InChI InChI=1S/C17H13FN6/c1-10-3-2-4-14(21-10)17-23-15-11(5-8-20-15)16(24-17)22-13-6-7-19-9-12(13)18/h2-9H,1H3,(H2,19,20,22,23,24)
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n/an/a 500n/an/an/an/an/an/a



Bristol-Myer Squibb Company

US Patent


Assay Description
Assays are conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGFβR1 T204D or HIS-TGFβR2 WT, anti-HIS detec...


US Patent US10399987 (2019)


BindingDB Entry DOI: 10.7270/Q2222X4N
More data for this
Ligand-Target Pair
TGF-beta receptor type II


(Homo sapiens (Human))
BDBM412747
PNG
(2-(6-(difluoromethyl)pyridin-2-yl)-4-(1H-pyrrolo[3...)
Show SMILES FC(F)c1cccc(n1)-c1nc(-n2ccc3cnccc23)c2cc[nH]c2n1
Show InChI InChI=1S/C19H12F2N6/c20-16(21)13-2-1-3-14(24-13)18-25-17-12(4-8-23-17)19(26-18)27-9-6-11-10-22-7-5-15(11)27/h1-10,16H,(H,23,25,26)
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n/an/a 590n/an/an/an/an/an/a



Bristol-Myer Squibb Company

US Patent


Assay Description
Assays are conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGFβR1 T204D or HIS-TGFβR2 WT, anti-HIS detec...


US Patent US10399987 (2019)


BindingDB Entry DOI: 10.7270/Q2222X4N
More data for this
Ligand-Target Pair
TGF-beta receptor type II


(Homo sapiens (Human))
BDBM412735
PNG
(2-(6-(difluoromethyl)pyridin-2-yl)-N-(3-fluoropyri...)
Show SMILES FC(F)c1cccc(n1)-c1nc(Nc2ccncc2F)c2cc[nH]c2n1
Show InChI InChI=1S/C17H11F3N6/c18-10-8-21-6-5-11(10)24-16-9-4-7-22-15(9)25-17(26-16)13-3-1-2-12(23-13)14(19)20/h1-8,14H,(H2,21,22,24,25,26)
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n/an/a 740n/an/an/an/an/an/a



Bristol-Myer Squibb Company

US Patent


Assay Description
Assays are conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGFβR1 T204D or HIS-TGFβR2 WT, anti-HIS detec...


US Patent US10399987 (2019)


BindingDB Entry DOI: 10.7270/Q2222X4N
More data for this
Ligand-Target Pair
TGF-beta receptor type II


(Homo sapiens (Human))
BDBM412778
PNG
(N-[4-({2-[6-(difluoromethyl)pyridin-2-yl]-5-{[(2-h...)
Show SMILES CC(=O)Nc1cc(Nc2nc(nc3[nH]cc(CNCC(C)(C)O)c23)-c2cccc(n2)C(F)F)ccn1
Show InChI InChI=1S/C24H26F2N8O2/c1-13(35)30-18-9-15(7-8-28-18)31-23-19-14(10-27-12-24(2,3)36)11-29-22(19)33-21(34-23)17-6-4-5-16(32-17)20(25)26/h4-9,11,20,27,36H,10,12H2,1-3H3,(H3,28,29,30,31,33,34,35)
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n/an/a 810n/an/an/an/an/an/a



Bristol-Myer Squibb Company

US Patent


Assay Description
Assays are conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGFβR1 T204D or HIS-TGFβR2 WT, anti-HIS detec...


US Patent US10399987 (2019)


BindingDB Entry DOI: 10.7270/Q2222X4N
More data for this
Ligand-Target Pair
TGF-beta receptor type-1 T204D


(Homo sapiens (Human))
BDBM412763
PNG
(N-(4-((2-(6-(trifluoromethyl)pyridin-2-yl)-7H-pyrr...)
Show SMILES CS(=O)(=O)Nc1cc(Nc2nc(nc3[nH]ccc23)-c2cccc(n2)C(F)(F)F)ccn1
Show InChI InChI=1S/C18H14F3N7O2S/c1-31(29,30)28-14-9-10(5-7-22-14)24-16-11-6-8-23-15(11)26-17(27-16)12-3-2-4-13(25-12)18(19,20)21/h2-9H,1H3,(H3,22,23,24,26,27,28)
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n/an/a 970n/an/an/an/an/an/a



Bristol-Myer Squibb Company

US Patent


Assay Description
Assays are conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGFβR1 T204D or HIS-TGFβR2 WT, anti-HIS detec...


US Patent US10399987 (2019)


BindingDB Entry DOI: 10.7270/Q2222X4N
More data for this
Ligand-Target Pair
TGF-beta receptor type II


(Homo sapiens (Human))
BDBM412768
PNG
(N-(3-fluoropyridin-4-yl)-5-methyl-2-(6-methylpyrid...)
Show SMILES Cc1c[nH]c2nc(nc(Nc3ccncc3F)c12)-c1cccc(C)n1
Show InChI InChI=1S/C18H15FN6/c1-10-8-21-17-15(10)18(23-13-6-7-20-9-12(13)19)25-16(24-17)14-5-3-4-11(2)22-14/h3-9H,1-2H3,(H2,20,21,23,24,25)
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n/an/a 1.20E+3n/an/an/an/an/an/a



Bristol-Myer Squibb Company

US Patent


Assay Description
Assays are conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGFβR1 T204D or HIS-TGFβR2 WT, anti-HIS detec...


US Patent US10399987 (2019)


BindingDB Entry DOI: 10.7270/Q2222X4N
More data for this
Ligand-Target Pair
TGF-beta receptor type II


(Homo sapiens (Human))
BDBM412766
PNG
(N-(4-((2-(6-(difluoromethyl)pyridin-2-yl)-7H-pyrro...)
Show SMILES CC(=O)Nc1nccc(Nc2nc(nc3[nH]ccc23)-c2cccc(n2)C(F)F)c1F
Show InChI InChI=1S/C19H14F3N7O/c1-9(30)25-19-14(20)11(6-8-24-19)27-17-10-5-7-23-16(10)28-18(29-17)13-4-2-3-12(26-13)15(21)22/h2-8,15H,1H3,(H3,23,24,25,27,28,29,30)
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n/an/a 1.20E+3n/an/an/an/an/an/a



Bristol-Myer Squibb Company

US Patent


Assay Description
Assays are conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGFβR1 T204D or HIS-TGFβR2 WT, anti-HIS detec...


US Patent US10399987 (2019)


BindingDB Entry DOI: 10.7270/Q2222X4N
More data for this
Ligand-Target Pair
TGF-beta receptor type II


(Homo sapiens (Human))
BDBM412781
PNG
(N-[2-(5-fluoro-6-methylpyridin-2-yl)-7H-pyrrolo[2,...)
Show SMILES COc1cnccc1Nc1nc(nc2[nH]ccc12)-c1ccc(F)c(C)n1
Show InChI InChI=1S/C18H15FN6O/c1-10-12(19)3-4-14(22-10)18-24-16-11(5-8-21-16)17(25-18)23-13-6-7-20-9-15(13)26-2/h3-9H,1-2H3,(H2,20,21,23,24,25)
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n/an/a 1.80E+3n/an/an/an/an/an/a



Bristol-Myer Squibb Company

US Patent


Assay Description
Assays are conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGFβR1 T204D or HIS-TGFβR2 WT, anti-HIS detec...


US Patent US10399987 (2019)


BindingDB Entry DOI: 10.7270/Q2222X4N
More data for this
Ligand-Target Pair
TGF-beta receptor type II


(Homo sapiens (Human))
BDBM412780
PNG
(N-[2-(5-fluoro-6-methylpyridin-2-yl)-7H-pyrrolo[2,...)
Show SMILES Cc1cnccc1Nc1nc(nc2[nH]ccc12)-c1ccc(F)c(C)n1
Show InChI InChI=1S/C18H15FN6/c1-10-9-20-7-6-14(10)23-17-12-5-8-21-16(12)24-18(25-17)15-4-3-13(19)11(2)22-15/h3-9H,1-2H3,(H2,20,21,23,24,25)
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n/an/a 3.40E+3n/an/an/an/an/an/a



Bristol-Myer Squibb Company

US Patent


Assay Description
Assays are conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGFβR1 T204D or HIS-TGFβR2 WT, anti-HIS detec...


US Patent US10399987 (2019)


BindingDB Entry DOI: 10.7270/Q2222X4N
More data for this
Ligand-Target Pair
TGF-beta receptor type II


(Homo sapiens (Human))
BDBM412760
PNG
(N-(4-((2-(6-(difluoromethyl)pyridin-2-yl)-5-methyl...)
Show SMILES CC(=O)Nc1cc(Nc2nc(nc3[nH]cc(C)c23)-c2cccc(n2)C(F)F)ccn1
Show InChI InChI=1S/C20H17F2N7O/c1-10-9-24-19-16(10)20(26-12-6-7-23-15(8-12)25-11(2)30)29-18(28-19)14-5-3-4-13(27-14)17(21)22/h3-9,17H,1-2H3,(H3,23,24,25,26,28,29,30)
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n/an/a 4.10E+3n/an/an/an/an/an/a



Bristol-Myer Squibb Company

US Patent


Assay Description
Assays are conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGFβR1 T204D or HIS-TGFβR2 WT, anti-HIS detec...


US Patent US10399987 (2019)


BindingDB Entry DOI: 10.7270/Q2222X4N
More data for this
Ligand-Target Pair
TGF-beta receptor type II


(Homo sapiens (Human))
BDBM412759
PNG
(N-(4-((2-(6-(trifluoromethyl)pyridin-2-yl)-7H-pyrr...)
Show SMILES CCC(=O)Nc1cc(Nc2nc(nc3[nH]ccc23)-c2cccc(n2)C(F)(F)F)ccn1
Show InChI InChI=1S/C20H16F3N7O/c1-2-16(31)28-15-10-11(6-8-24-15)26-18-12-7-9-25-17(12)29-19(30-18)13-4-3-5-14(27-13)20(21,22)23/h3-10H,2H2,1H3,(H3,24,25,26,28,29,30,31)
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n/an/a 4.80E+3n/an/an/an/an/an/a



Bristol-Myer Squibb Company

US Patent


Assay Description
Assays are conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGFβR1 T204D or HIS-TGFβR2 WT, anti-HIS detec...


US Patent US10399987 (2019)


BindingDB Entry DOI: 10.7270/Q2222X4N
More data for this
Ligand-Target Pair
TGF-beta receptor type II


(Homo sapiens (Human))
BDBM412755
PNG
(N-(4-((2-(6-(trifluoromethyl)pyridin-2-yl)-7H-pyrr...)
Show SMILES CC(=O)Nc1cc(Nc2nc(nc3[nH]ccc23)-c2cccc(n2)C(F)(F)F)ccn1
Show InChI InChI=1S/C19H14F3N7O/c1-10(30)25-15-9-11(5-7-23-15)26-17-12-6-8-24-16(12)28-18(29-17)13-3-2-4-14(27-13)19(20,21)22/h2-9H,1H3,(H3,23,24,25,26,28,29,30)
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n/an/a 5.00E+3n/an/an/an/an/an/a



Bristol-Myer Squibb Company

US Patent


Assay Description
Assays are conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGFβR1 T204D or HIS-TGFβR2 WT, anti-HIS detec...


US Patent US10399987 (2019)


BindingDB Entry DOI: 10.7270/Q2222X4N
More data for this
Ligand-Target Pair
TGF-beta receptor type II


(Homo sapiens (Human))
BDBM412770
PNG
(1-(((2-(6-(difluoromethyl)pyridin-2-yl)-4-((3-fluo...)
Show SMILES CC(C)(O)CNCc1c[nH]c2nc(nc(Nc3ccncc3F)c12)-c1cccc(n1)C(F)F
Show InChI InChI=1S/C22H22F3N7O/c1-22(2,33)11-27-8-12-9-28-20-17(12)21(30-14-6-7-26-10-13(14)23)32-19(31-20)16-5-3-4-15(29-16)18(24)25/h3-7,9-10,18,27,33H,8,11H2,1-2H3,(H2,26,28,30,31,32)
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n/an/a 5.20E+3n/an/an/an/an/an/a



Bristol-Myer Squibb Company

US Patent


Assay Description
Assays are conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGFβR1 T204D or HIS-TGFβR2 WT, anti-HIS detec...


US Patent US10399987 (2019)


BindingDB Entry DOI: 10.7270/Q2222X4N
More data for this
Ligand-Target Pair
TGF-beta receptor type II


(Homo sapiens (Human))
BDBM412758
PNG
(N-(4-((2-(5-(trifluoromethyl)pyridin-2-yl)-7H-pyrr...)
Show SMILES CC(=O)Nc1cc(Nc2nc(nc3[nH]ccc23)-c2ccc(cn2)C(F)(F)F)ccn1
Show InChI InChI=1S/C19H14F3N7O/c1-10(30)26-15-8-12(4-6-23-15)27-17-13-5-7-24-16(13)28-18(29-17)14-3-2-11(9-25-14)19(20,21)22/h2-9H,1H3,(H3,23,24,26,27,28,29,30)
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n/an/a>1.50E+4n/an/an/an/an/an/a



Bristol-Myer Squibb Company

US Patent


Assay Description
Assays are conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGFβR1 T204D or HIS-TGFβR2 WT, anti-HIS detec...


US Patent US10399987 (2019)


BindingDB Entry DOI: 10.7270/Q2222X4N
More data for this
Ligand-Target Pair
TGF-beta receptor type II


(Homo sapiens (Human))
BDBM412769
PNG
(N-(3-fluoropyridin-4-yl)-5-methyl-2-(6-(trifluorom...)
Show SMILES Cc1c[nH]c2nc(nc(Nc3ccncc3F)c12)-c1cccc(n1)C(F)(F)F
Show InChI InChI=1S/C18H12F4N6/c1-9-7-24-16-14(9)17(26-11-5-6-23-8-10(11)19)28-15(27-16)12-3-2-4-13(25-12)18(20,21)22/h2-8H,1H3,(H2,23,24,26,27,28)
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n/an/a>1.50E+4n/an/an/an/an/an/a



Bristol-Myer Squibb Company

US Patent


Assay Description
Assays are conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGFβR1 T204D or HIS-TGFβR2 WT, anti-HIS detec...


US Patent US10399987 (2019)


BindingDB Entry DOI: 10.7270/Q2222X4N
More data for this
Ligand-Target Pair
TGF-beta receptor type II


(Homo sapiens (Human))
BDBM412775
PNG
(3-chloro-N-{2-[6-(trifluoromethyl)pyridin-2-yl]-7H...)
Show SMILES FC(F)(F)c1cccc(n1)-c1nc(Nc2ccncc2Cl)c2cc[nH]c2n1
Show InChI InChI=1S/C17H10ClF3N6/c18-10-8-22-6-5-11(10)25-15-9-4-7-23-14(9)26-16(27-15)12-2-1-3-13(24-12)17(19,20)21/h1-8H,(H2,22,23,25,26,27)
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n/an/a>1.50E+4n/an/an/an/an/an/a



Bristol-Myer Squibb Company

US Patent


Assay Description
Assays are conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGFβR1 T204D or HIS-TGFβR2 WT, anti-HIS detec...


US Patent US10399987 (2019)


BindingDB Entry DOI: 10.7270/Q2222X4N
More data for this
Ligand-Target Pair
TGF-beta receptor type II


(Homo sapiens (Human))
BDBM412742
PNG
(2-(6-(difluoromethyl)pyridin-2-yl)-N-(3-fluoropyri...)
Show SMILES CN1CCN(Cc2c[nH]c3nc(nc(Nc4ccncc4F)c23)-c2cccc(n2)C(F)F)CC1
Show InChI InChI=1S/C23H23F3N8/c1-33-7-9-34(10-8-33)13-14-11-28-22-19(14)23(30-16-5-6-27-12-15(16)24)32-21(31-22)18-4-2-3-17(29-18)20(25)26/h2-6,11-12,20H,7-10,13H2,1H3,(H2,27,28,30,31,32)
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n/an/a>1.50E+4n/an/an/an/an/an/a



Bristol-Myer Squibb Company

US Patent


Assay Description
Assays are conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGFβR1 T204D or HIS-TGFβR2 WT, anti-HIS detec...


US Patent US10399987 (2019)


BindingDB Entry DOI: 10.7270/Q2222X4N
More data for this
Ligand-Target Pair
TGF-beta receptor type II


(Homo sapiens (Human))
BDBM412748
PNG
(N-(2-chloro-5-fluoropyridin-4-yl)-2-(5-fluoro-6-me...)
Show SMILES Cc1nc(ccc1F)-c1nc(Nc2cc(Cl)ncc2F)c2cc[nH]c2n1
Show InChI InChI=1S/C17H11ClF2N6/c1-8-10(19)2-3-12(23-8)17-25-15-9(4-5-21-15)16(26-17)24-13-6-14(18)22-7-11(13)20/h2-7H,1H3,(H2,21,22,24,25,26)
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n/an/a>1.50E+4n/an/an/an/an/an/a



Bristol-Myer Squibb Company

US Patent


Assay Description
Assays are conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGFβR1 T204D or HIS-TGFβR2 WT, anti-HIS detec...


US Patent US10399987 (2019)


BindingDB Entry DOI: 10.7270/Q2222X4N
More data for this
Ligand-Target Pair
TGF-beta receptor type II


(Homo sapiens (Human))
BDBM412762
PNG
(3-methyl-N-(4-((2-(6-(trifluoromethyl)pyridin-2-yl...)
Show SMILES CC(C)CC(=O)Nc1cc(Nc2nc(nc3[nH]ccc23)-c2cccc(n2)C(F)(F)F)ccn1
Show InChI InChI=1S/C22H20F3N7O/c1-12(2)10-18(33)30-17-11-13(6-8-26-17)28-20-14-7-9-27-19(14)31-21(32-20)15-4-3-5-16(29-15)22(23,24)25/h3-9,11-12H,10H2,1-2H3,(H3,26,27,28,30,31,32,33)
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n/an/a>1.50E+4n/an/an/an/an/an/a



Bristol-Myer Squibb Company

US Patent


Assay Description
Assays are conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGFβR1 T204D or HIS-TGFβR2 WT, anti-HIS detec...


US Patent US10399987 (2019)


BindingDB Entry DOI: 10.7270/Q2222X4N
More data for this
Ligand-Target Pair
TGF-beta receptor type II


(Homo sapiens (Human))
BDBM412763
PNG
(N-(4-((2-(6-(trifluoromethyl)pyridin-2-yl)-7H-pyrr...)
Show SMILES CS(=O)(=O)Nc1cc(Nc2nc(nc3[nH]ccc23)-c2cccc(n2)C(F)(F)F)ccn1
Show InChI InChI=1S/C18H14F3N7O2S/c1-31(29,30)28-14-9-10(5-7-22-14)24-16-11-6-8-23-15(11)26-17(27-16)12-3-2-4-13(25-12)18(19,20)21/h2-9H,1H3,(H3,22,23,24,26,27,28)
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n/an/a>1.50E+4n/an/an/an/an/an/a



Bristol-Myer Squibb Company

US Patent


Assay Description
Assays are conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGFβR1 T204D or HIS-TGFβR2 WT, anti-HIS detec...


US Patent US10399987 (2019)


BindingDB Entry DOI: 10.7270/Q2222X4N
More data for this
Ligand-Target Pair
TGF-beta receptor type II


(Homo sapiens (Human))
BDBM412771
PNG
(N-[3-fluoro-4-({2-[6-(trifluoromethyl)pyridin-2-yl...)
Show SMILES CC(=O)Nc1nccc(Nc2nc(nc3[nH]ccc23)-c2cccc(n2)C(F)(F)F)c1F
Show InChI InChI=1S/C19H13F4N7O/c1-9(31)26-18-14(20)11(6-8-25-18)28-16-10-5-7-24-15(10)29-17(30-16)12-3-2-4-13(27-12)19(21,22)23/h2-8H,1H3,(H3,24,25,26,28,29,30,31)
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n/an/a>1.50E+4n/an/an/an/an/an/a



Bristol-Myer Squibb Company

US Patent


Assay Description
Assays are conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGFβR1 T204D or HIS-TGFβR2 WT, anti-HIS detec...


US Patent US10399987 (2019)


BindingDB Entry DOI: 10.7270/Q2222X4N
More data for this
Ligand-Target Pair
TGF-beta receptor type II


(Homo sapiens (Human))
BDBM412773
PNG
(N-methyl-N-{2-[6-(trifluoromethyl)pyridin-2-yl]-7H...)
Show SMILES CN(c1ccncc1)c1nc(nc2[nH]ccc12)-c1cccc(n1)C(F)(F)F
Show InChI InChI=1S/C18H13F3N6/c1-27(11-5-8-22-9-6-11)17-12-7-10-23-15(12)25-16(26-17)13-3-2-4-14(24-13)18(19,20)21/h2-10H,1H3,(H,23,25,26)
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n/an/a>1.50E+4n/an/an/an/an/an/a



Bristol-Myer Squibb Company

US Patent


Assay Description
Assays are conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGFβR1 T204D or HIS-TGFβR2 WT, anti-HIS detec...


US Patent US10399987 (2019)


BindingDB Entry DOI: 10.7270/Q2222X4N
More data for this
Ligand-Target Pair
TGF-beta receptor type II


(Homo sapiens (Human))
BDBM412738
PNG
(2-(pyrrolidin-1-yl)-N-(4-((2-(6-(trifluoromethyl)p...)
Show SMILES FC(F)(F)c1cccc(n1)-c1nc(Nc2ccnc(NC(=O)CN3CCCC3)c2)c2cc[nH]c2n1
Show InChI InChI=1S/C23H21F3N8O/c24-23(25,26)17-5-3-4-16(30-17)22-32-20-15(7-9-28-20)21(33-22)29-14-6-8-27-18(12-14)31-19(35)13-34-10-1-2-11-34/h3-9,12H,1-2,10-11,13H2,(H3,27,28,29,31,32,33,35)
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Bristol-Myer Squibb Company

US Patent


Assay Description
Assays are conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGFβR1 T204D or HIS-TGFβR2 WT, anti-HIS detec...


US Patent US10399987 (2019)


BindingDB Entry DOI: 10.7270/Q2222X4N
More data for this
Ligand-Target Pair
TGF-beta receptor type II


(Homo sapiens (Human))
BDBM412754
PNG
(1-(4-((2-(6-(difluoromethyl)pyridin-2-yl)-7H-pyrro...)
Show SMILES FC(F)c1cccc(n1)-c1nc(Nc2ccnc(c2)N2CCCC2=O)c2cc[nH]c2n1
Show InChI InChI=1S/C21H17F2N7O/c22-18(23)14-3-1-4-15(27-14)21-28-19-13(7-9-25-19)20(29-21)26-12-6-8-24-16(11-12)30-10-2-5-17(30)31/h1,3-4,6-9,11,18H,2,5,10H2,(H2,24,25,26,28,29)
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Bristol-Myer Squibb Company

US Patent


Assay Description
Assays are conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGFβR1 T204D or HIS-TGFβR2 WT, anti-HIS detec...


US Patent US10399987 (2019)


BindingDB Entry DOI: 10.7270/Q2222X4N
More data for this
Ligand-Target Pair
TGF-beta receptor type II


(Homo sapiens (Human))
BDBM412784
PNG
(N-(6-{4-[(3-chloropyridin-4-yl)amino]-7H-pyrrolo[2...)
Show SMILES CS(=O)(=O)Nc1cccc(n1)-c1nc(Nc2ccncc2Cl)c2cc[nH]c2n1
Show InChI InChI=1S/C17H14ClN7O2S/c1-28(26,27)25-14-4-2-3-13(21-14)17-23-15-10(5-8-20-15)16(24-17)22-12-6-7-19-9-11(12)18/h2-9H,1H3,(H,21,25)(H2,19,20,22,23,24)
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Bristol-Myer Squibb Company

US Patent


Assay Description
Assays are conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGFβR1 T204D or HIS-TGFβR2 WT, anti-HIS detec...


US Patent US10399987 (2019)


BindingDB Entry DOI: 10.7270/Q2222X4N
More data for this
Ligand-Target Pair
TGF-beta receptor type II


(Homo sapiens (Human))
BDBM412739
PNG
(2-(4-methylpiperazin-1-yl)-N-(4-((2-(6-(trifluorom...)
Show SMILES CN1CCN(CC(=O)Nc2cc(Nc3nc(nc4[nH]ccc34)-c3cccc(n3)C(F)(F)F)ccn2)CC1
Show InChI InChI=1S/C24H24F3N9O/c1-35-9-11-36(12-10-35)14-20(37)32-19-13-15(5-7-28-19)30-22-16-6-8-29-21(16)33-23(34-22)17-3-2-4-18(31-17)24(25,26)27/h2-8,13H,9-12,14H2,1H3,(H3,28,29,30,32,33,34,37)
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Bristol-Myer Squibb Company

US Patent


Assay Description
Assays are conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGFβR1 T204D or HIS-TGFβR2 WT, anti-HIS detec...


US Patent US10399987 (2019)


BindingDB Entry DOI: 10.7270/Q2222X4N
More data for this
Ligand-Target Pair
TGF-beta receptor type II


(Homo sapiens (Human))
BDBM412767
PNG
(2-morpholino-N-(4-((2-(6-(trifluoromethyl)pyridin-...)
Show SMILES FC(F)(F)c1cccc(n1)-c1nc(Nc2ccnc(NC(=O)CN3CCOCC3)c2)c2cc[nH]c2n1
Show InChI InChI=1S/C23H21F3N8O2/c24-23(25,26)17-3-1-2-16(30-17)22-32-20-15(5-7-28-20)21(33-22)29-14-4-6-27-18(12-14)31-19(35)13-34-8-10-36-11-9-34/h1-7,12H,8-11,13H2,(H3,27,28,29,31,32,33,35)
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Bristol-Myer Squibb Company

US Patent


Assay Description
Assays are conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGFβR1 T204D or HIS-TGFβR2 WT, anti-HIS detec...


US Patent US10399987 (2019)


BindingDB Entry DOI: 10.7270/Q2222X4N
More data for this
Ligand-Target Pair
TGF-beta receptor type II


(Homo sapiens (Human))
BDBM412774
PNG
(3-(trifluoromethyl)-N-{2-[6-(trifluoromethyl)pyrid...)
Show SMILES FC(F)(F)c1cccc(n1)-c1nc(Nc2ccncc2C(F)(F)F)c2cc[nH]c2n1
Show InChI InChI=1S/C18H10F6N6/c19-17(20,21)10-8-25-6-5-11(10)28-15-9-4-7-26-14(9)29-16(30-15)12-2-1-3-13(27-12)18(22,23)24/h1-8H,(H2,25,26,28,29,30)
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Bristol-Myer Squibb Company

US Patent


Assay Description
Assays are conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGFβR1 T204D or HIS-TGFβR2 WT, anti-HIS detec...


US Patent US10399987 (2019)


BindingDB Entry DOI: 10.7270/Q2222X4N
More data for this
Ligand-Target Pair
TGF-beta receptor type II


(Homo sapiens (Human))
BDBM412750
PNG
(N-(2-chloropyrimidin-4-yl)-2-(6-(difluoromethyl)py...)
Show SMILES FC(F)c1cccc(n1)-c1nc(Nc2ccnc(Cl)n2)c2cc[nH]c2n1
Show InChI InChI=1S/C16H10ClF2N7/c17-16-21-7-5-11(24-16)23-14-8-4-6-20-13(8)25-15(26-14)10-3-1-2-9(22-10)12(18)19/h1-7,12H,(H2,20,21,23,24,25,26)
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Bristol-Myer Squibb Company

US Patent


Assay Description
Assays are conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGFβR1 T204D or HIS-TGFβR2 WT, anti-HIS detec...


US Patent US10399987 (2019)


BindingDB Entry DOI: 10.7270/Q2222X4N
More data for this
Ligand-Target Pair
TGF-beta receptor type II


(Homo sapiens (Human))
BDBM412745
PNG
(N-(3-fluoropyridin-4-yl)-2-(6-(trifluoromethyl)pyr...)
Show SMILES Fc1cnccc1Nc1nc(nc2[nH]ccc12)-c1cccc(n1)C(F)(F)F
Show InChI InChI=1S/C17H10F4N6/c18-10-8-22-6-5-11(10)25-15-9-4-7-23-14(9)26-16(27-15)12-2-1-3-13(24-12)17(19,20)21/h1-8H,(H2,22,23,25,26,27)
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Bristol-Myer Squibb Company

US Patent


Assay Description
Assays are conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGFβR1 T204D or HIS-TGFβR2 WT, anti-HIS detec...


US Patent US10399987 (2019)


BindingDB Entry DOI: 10.7270/Q2222X4N
More data for this
Ligand-Target Pair
TGF-beta receptor type II


(Homo sapiens (Human))
BDBM412741
PNG
(2-(6-(difluoromethyl)pyridin-2-yl)-N-(3-fluoropyri...)
Show SMILES Cc1c[nH]c2nc(nc(Nc3ccncc3F)c12)-c1cccc(n1)C(F)F
Show InChI InChI=1S/C18H13F3N6/c1-9-7-23-17-14(9)18(25-11-5-6-22-8-10(11)19)27-16(26-17)13-4-2-3-12(24-13)15(20)21/h2-8,15H,1H3,(H2,22,23,25,26,27)
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Bristol-Myer Squibb Company

US Patent


Assay Description
Assays are conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGFβR1 T204D or HIS-TGFβR2 WT, anti-HIS detec...


US Patent US10399987 (2019)


BindingDB Entry DOI: 10.7270/Q2222X4N
More data for this
Ligand-Target Pair
TGF-beta receptor type II


(Homo sapiens (Human))
BDBM412772
PNG
(3-methyl-N-{2-[6-(trifluoromethyl)pyridin-2-yl]-7H...)
Show SMILES Cc1cnccc1Nc1nc(nc2[nH]ccc12)-c1cccc(n1)C(F)(F)F
Show InChI InChI=1S/C18H13F3N6/c1-10-9-22-7-6-12(10)25-16-11-5-8-23-15(11)26-17(27-16)13-3-2-4-14(24-13)18(19,20)21/h2-9H,1H3,(H2,22,23,25,26,27)
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Bristol-Myer Squibb Company

US Patent


Assay Description
Assays are conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGFβR1 T204D or HIS-TGFβR2 WT, anti-HIS detec...


US Patent US10399987 (2019)


BindingDB Entry DOI: 10.7270/Q2222X4N
More data for this
Ligand-Target Pair
TGF-beta receptor type II


(Homo sapiens (Human))
BDBM412761
PNG
(3,3-dimethyl-N-(4-((2-(6-(trifluoromethyl)pyridin-...)
Show SMILES CC(C)(C)CC(=O)Nc1cc(Nc2nc(nc3[nH]ccc23)-c2cccc(n2)C(F)(F)F)ccn1
Show InChI InChI=1S/C23H22F3N7O/c1-22(2,3)12-18(34)31-17-11-13(7-9-27-17)29-20-14-8-10-28-19(14)32-21(33-20)15-5-4-6-16(30-15)23(24,25)26/h4-11H,12H2,1-3H3,(H3,27,28,29,31,32,33,34)
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Bristol-Myer Squibb Company

US Patent


Assay Description
Assays are conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGFβR1 T204D or HIS-TGFβR2 WT, anti-HIS detec...


US Patent US10399987 (2019)


BindingDB Entry DOI: 10.7270/Q2222X4N
More data for this
Ligand-Target Pair
TGF-beta receptor type II


(Homo sapiens (Human))
BDBM412779
PNG
(N-[4-({2-[6-(difluoromethyl)pyridin-2-yl]-5-{[(2-h...)
Show SMILES CC(=O)Nc1cc(Nc2nc(nc3[nH]cc(CNCC(C)(C)O)c23)-c2cccc(n2)C(F)F)c(F)cn1
Show InChI InChI=1S/C24H25F3N8O2/c1-12(36)31-18-7-17(14(25)10-29-18)33-23-19-13(8-28-11-24(2,3)37)9-30-22(19)34-21(35-23)16-6-4-5-15(32-16)20(26)27/h4-7,9-10,20,28,37H,8,11H2,1-3H3,(H3,29,30,31,33,34,35,36)
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Bristol-Myer Squibb Company

US Patent


Assay Description
Assays are conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGFβR1 T204D or HIS-TGFβR2 WT, anti-HIS detec...


US Patent US10399987 (2019)


BindingDB Entry DOI: 10.7270/Q2222X4N
More data for this
Ligand-Target Pair
TGF-beta receptor type II


(Homo sapiens (Human))
BDBM412777
PNG
(3-methoxy-N-{2-[6-(trifluoromethyl)pyridin-2-yl]-7...)
Show SMILES COc1cnccc1Nc1nc(nc2[nH]ccc12)-c1cccc(n1)C(F)(F)F
Show InChI InChI=1S/C18H13F3N6O/c1-28-13-9-22-7-6-11(13)25-16-10-5-8-23-15(10)26-17(27-16)12-3-2-4-14(24-12)18(19,20)21/h2-9H,1H3,(H2,22,23,25,26,27)
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Bristol-Myer Squibb Company

US Patent


Assay Description
Assays are conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGFβR1 T204D or HIS-TGFβR2 WT, anti-HIS detec...


US Patent US10399987 (2019)


BindingDB Entry DOI: 10.7270/Q2222X4N
More data for this
Ligand-Target Pair
TGF-beta receptor type II


(Homo sapiens (Human))
BDBM412765
PNG
(US10399987, Example 30 | methyl (4-((2-(6-(trifluo...)
Show SMILES COC(=O)Nc1cc(Nc2nc(nc3[nH]ccc23)-c2cccc(n2)C(F)(F)F)ccn1
Show InChI InChI=1S/C19H14F3N7O2/c1-31-18(30)27-14-9-10(5-7-23-14)25-16-11-6-8-24-15(11)28-17(29-16)12-3-2-4-13(26-12)19(20,21)22/h2-9H,1H3,(H3,23,24,25,27,28,29,30)
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Bristol-Myer Squibb Company

US Patent


Assay Description
Assays are conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGFβR1 T204D or HIS-TGFβR2 WT, anti-HIS detec...


US Patent US10399987 (2019)


BindingDB Entry DOI: 10.7270/Q2222X4N
More data for this
Ligand-Target Pair
TGF-beta receptor type II


(Homo sapiens (Human))
BDBM412783
PNG
(N-(6-{4-[methyl(pyridin-4-yl)amino]-7H-pyrrolo[2,3...)
Show SMILES CN(c1ccncc1)c1nc(nc2[nH]ccc12)-c1cccc(NS(C)(=O)=O)n1
Show InChI InChI=1S/C18H17N7O2S/c1-25(12-6-9-19-10-7-12)18-13-8-11-20-16(13)22-17(23-18)14-4-3-5-15(21-14)24-28(2,26)27/h3-11H,1-2H3,(H,21,24)(H,20,22,23)
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Bristol-Myer Squibb Company

US Patent


Assay Description
Assays are conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGFβR1 T204D or HIS-TGFβR2 WT, anti-HIS detec...


US Patent US10399987 (2019)


BindingDB Entry DOI: 10.7270/Q2222X4N
More data for this
Ligand-Target Pair
TGF-beta receptor type II


(Homo sapiens (Human))
BDBM412751
PNG
(N-(4-((2-(6-(difluoromethyl)pyridin-2-yl)-7H-pyrro...)
Show SMILES CC(=O)Nc1cc(Nc2nc(nc3[nH]ccc23)-c2cccc(n2)C(F)F)c(F)cn1
Show InChI InChI=1S/C19H14F3N7O/c1-9(30)25-15-7-14(11(20)8-24-15)27-18-10-5-6-23-17(10)28-19(29-18)13-4-2-3-12(26-13)16(21)22/h2-8,16H,1H3,(H3,23,24,25,27,28,29,30)
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n/an/a>1.50E+4n/an/an/an/an/an/a



Bristol-Myer Squibb Company

US Patent


Assay Description
Assays are conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGFβR1 T204D or HIS-TGFβR2 WT, anti-HIS detec...


US Patent US10399987 (2019)


BindingDB Entry DOI: 10.7270/Q2222X4N
More data for this
Ligand-Target Pair
TGF-beta receptor type II


(Homo sapiens (Human))
BDBM412753
PNG
(N-(5-fluoro-4-((2-(5-fluoro-6-methylpyridin-2-yl)-...)
Show SMILES CC(=O)Nc1cc(Nc2nc(nc3[nH]ccc23)-c2ccc(F)c(n2)C(F)F)c(F)cn1
Show InChI InChI=1S/C19H13F4N7O/c1-8(31)26-14-6-13(11(21)7-25-14)28-18-9-4-5-24-17(9)29-19(30-18)12-3-2-10(20)15(27-12)16(22)23/h2-7,16H,1H3,(H3,24,25,26,28,29,30,31)
PDB
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UniProtKB/SwissProt
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antibodypedia
GoogleScholar
UniChem
US Patent
n/an/a>1.50E+4n/an/an/an/an/an/a



Bristol-Myer Squibb Company

US Patent


Assay Description
Assays are conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGFβR1 T204D or HIS-TGFβR2 WT, anti-HIS detec...


US Patent US10399987 (2019)


BindingDB Entry DOI: 10.7270/Q2222X4N
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%