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Patent code US10399991

Compile Data Set for Download or QSAR
Found 64 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Voltage-gated potassium channel


(Homo sapiens (Human))
BDBM412926
PNG
(US10399991, Example 43 | US10822345, Ex 43)
Show SMILES Cc1csc2c(C)c3oc(=O)c(C)c(-c4ccccc4)c3cc12
Show InChI InChI=1S/C20H16O2S/c1-11-10-23-19-13(3)18-16(9-15(11)19)17(12(2)20(21)22-18)14-7-5-4-6-8-14/h4-10H,1-3H3
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4SC AG

US Patent


Assay Description
For a description of a Kv1.3 patch-clamp assay, see Grissmer et al., Mol. Pharmacol. 1994, 45, 1227; whole cell patch-clamp recording was performed w...


US Patent US10399991 (2019)


BindingDB Entry DOI: 10.7270/Q2SJ1P0X
More data for this
Ligand-Target Pair
Voltage-gated potassium channel


(Homo sapiens (Human))
BDBM412944
PNG
(US10399991, Example 61 | US10822345, Ex 61)
Show SMILES Cc1coc2c(C)c3n(C)c(=O)c(C)c(-c4ccccc4F)c3cc12
Show InChI InChI=1S/C21H18FNO2/c1-11-10-25-20-13(3)19-16(9-15(11)20)18(12(2)21(24)23(19)4)14-7-5-6-8-17(14)22/h5-10H,1-4H3
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4SC AG

US Patent


Assay Description
For a description of a Kv1.3 patch-clamp assay, see Grissmer et al., Mol. Pharmacol. 1994, 45, 1227; whole cell patch-clamp recording was performed w...


US Patent US10399991 (2019)


BindingDB Entry DOI: 10.7270/Q2SJ1P0X
More data for this
Ligand-Target Pair
Voltage-gated potassium channel


(Homo sapiens (Human))
BDBM412909
PNG
(US10399991, Example 26 | US10822345, Ex 26)
Show SMILES Cc1coc2c(C)c3[nH]c(=O)c(Br)c(-c4ccccc4)c3cc12
Show InChI InChI=1S/C19H14BrNO2/c1-10-9-23-18-11(2)17-14(8-13(10)18)15(16(20)19(22)21-17)12-6-4-3-5-7-12/h3-9H,1-2H3,(H,21,22)
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4SC AG

US Patent


Assay Description
For a description of a Kv1.3 patch-clamp assay, see Grissmer et al., Mol. Pharmacol. 1994, 45, 1227; whole cell patch-clamp recording was performed w...


US Patent US10399991 (2019)


BindingDB Entry DOI: 10.7270/Q2SJ1P0X
More data for this
Ligand-Target Pair
Voltage-gated potassium channel


(Homo sapiens (Human))
BDBM412893
PNG
(US10399991, Example 10 | US10822345, Ex 10)
Show SMILES CCOc1ccccc1-c1c(C)c(=O)oc2c(C)c3occ(C)c3cc12
Show InChI InChI=1S/C22H20O4/c1-5-24-18-9-7-6-8-15(18)19-13(3)22(23)26-21-14(4)20-16(10-17(19)21)12(2)11-25-20/h6-11H,5H2,1-4H3
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4SC AG

US Patent


Assay Description
For a description of a Kv1.3 patch-clamp assay, see Grissmer et al., Mol. Pharmacol. 1994, 45, 1227; whole cell patch-clamp recording was performed w...


US Patent US10399991 (2019)


BindingDB Entry DOI: 10.7270/Q2SJ1P0X
More data for this
Ligand-Target Pair
Voltage-gated potassium channel


(Homo sapiens (Human))
BDBM412890
PNG
(US10399991, Example 7 | US10822345, Ex 7)
Show SMILES COc1ccccc1-c1c(C)c(=O)oc2c(C)c3occ(C)c3cc12
Show InChI InChI=1S/C21H18O4/c1-11-10-24-19-13(3)20-16(9-15(11)19)18(12(2)21(22)25-20)14-7-5-6-8-17(14)23-4/h5-10H,1-4H3
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4SC AG

US Patent


Assay Description
For a description of a Kv1.3 patch-clamp assay, see Grissmer et al., Mol. Pharmacol. 1994, 45, 1227; whole cell patch-clamp recording was performed w...


US Patent US10399991 (2019)


BindingDB Entry DOI: 10.7270/Q2SJ1P0X
More data for this
Ligand-Target Pair
Voltage-gated potassium channel


(Homo sapiens (Human))
BDBM412888
PNG
(US10399991, Example 5 | US10822345, Ex 5)
Show SMILES Cc1coc2c(C)c3oc(=O)c(C)c(-c4ccccc4F)c3cc12
Show InChI InChI=1S/C20H15FO3/c1-10-9-23-18-12(3)19-15(8-14(10)18)17(11(2)20(22)24-19)13-6-4-5-7-16(13)21/h4-9H,1-3H3
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4SC AG

US Patent


Assay Description
For a description of a Kv1.3 patch-clamp assay, see Grissmer et al., Mol. Pharmacol. 1994, 45, 1227; whole cell patch-clamp recording was performed w...


US Patent US10399991 (2019)


BindingDB Entry DOI: 10.7270/Q2SJ1P0X
More data for this
Ligand-Target Pair
Voltage-gated potassium channel


(Homo sapiens (Human))
BDBM412936
PNG
(US10399991, Example 53 | US10822345, Ex 53)
Show SMILES Cc1coc2c(C)c3oc(=O)c(C)c(-c4cccnc4)c3cc12
Show InChI InChI=1S/C19H15NO3/c1-10-9-22-17-12(3)18-15(7-14(10)17)16(11(2)19(21)23-18)13-5-4-6-20-8-13/h4-9H,1-3H3
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4SC AG

US Patent


Assay Description
For a description of a Kv1.3 patch-clamp assay, see Grissmer et al., Mol. Pharmacol. 1994, 45, 1227; whole cell patch-clamp recording was performed w...


US Patent US10399991 (2019)


BindingDB Entry DOI: 10.7270/Q2SJ1P0X
More data for this
Ligand-Target Pair
Voltage-gated potassium channel


(Homo sapiens (Human))
BDBM412923
PNG
(US10399991, Example 40 | US10822345, Ex 40)
Show SMILES Cc1coc2c(C)c3[nH]c(=O)c(C)c(-c4ccccc4Cl)c3cc12
Show InChI InChI=1S/C20H16ClNO2/c1-10-9-24-19-12(3)18-15(8-14(10)19)17(11(2)20(23)22-18)13-6-4-5-7-16(13)21/h4-9H,1-3H3,(H,22,23)
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4SC AG

US Patent


Assay Description
For a description of a Kv1.3 patch-clamp assay, see Grissmer et al., Mol. Pharmacol. 1994, 45, 1227; whole cell patch-clamp recording was performed w...


US Patent US10399991 (2019)


BindingDB Entry DOI: 10.7270/Q2SJ1P0X
More data for this
Ligand-Target Pair
Voltage-gated potassium channel


(Homo sapiens (Human))
BDBM412917
PNG
(US10399991, Example 34 | US10822345, Ex 34)
Show SMILES Cc1coc2c(C)c3n(C)c(=O)c(C)c(-c4ccccc4)c3cc12
Show InChI InChI=1S/C21H19NO2/c1-12-11-24-20-14(3)19-17(10-16(12)20)18(13(2)21(23)22(19)4)15-8-6-5-7-9-15/h5-11H,1-4H3
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4SC AG

US Patent


Assay Description
For a description of a Kv1.3 patch-clamp assay, see Grissmer et al., Mol. Pharmacol. 1994, 45, 1227; whole cell patch-clamp recording was performed w...


US Patent US10399991 (2019)


BindingDB Entry DOI: 10.7270/Q2SJ1P0X
More data for this
Ligand-Target Pair
Voltage-gated potassium channel


(Homo sapiens (Human))
BDBM412937
PNG
(US10399991, Example 54 | US10822345, Ex 54)
Show SMILES Cc1coc2c(C)c3[nH]c(=O)c(C)c(-c4cccnc4)c3cc12
Show InChI InChI=1S/C19H16N2O2/c1-10-9-23-18-12(3)17-15(7-14(10)18)16(11(2)19(22)21-17)13-5-4-6-20-8-13/h4-9H,1-3H3,(H,21,22)
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4SC AG

US Patent


Assay Description
For a description of a Kv1.3 patch-clamp assay, see Grissmer et al., Mol. Pharmacol. 1994, 45, 1227; whole cell patch-clamp recording was performed w...


US Patent US10399991 (2019)


BindingDB Entry DOI: 10.7270/Q2SJ1P0X
More data for this
Ligand-Target Pair
Voltage-gated potassium channel


(Homo sapiens (Human))
BDBM412919
PNG
(US10399991, Example 36 | US10822345, Ex 36)
Show SMILES Cc1noc2c(C)c3[nH]c(=O)c(C)c(-c4ccccc4)c3cc12
Show InChI InChI=1S/C19H16N2O2/c1-10-16(13-7-5-4-6-8-13)15-9-14-12(3)21-23-18(14)11(2)17(15)20-19(10)22/h4-9H,1-3H3,(H,20,22)
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4SC AG

US Patent


Assay Description
For a description of a Kv1.3 patch-clamp assay, see Grissmer et al., Mol. Pharmacol. 1994, 45, 1227; whole cell patch-clamp recording was performed w...


US Patent US10399991 (2019)


BindingDB Entry DOI: 10.7270/Q2SJ1P0X
More data for this
Ligand-Target Pair
Voltage-gated potassium channel


(Homo sapiens (Human))
BDBM412908
PNG
(US10399991, Example 25 | US10822345, Ex 25)
Show SMILES Cc1coc2nc3oc(=O)c(C)c(-c4ccccc4)c3cc12
Show InChI InChI=1S/C18H13NO3/c1-10-9-21-16-13(10)8-14-15(12-6-4-3-5-7-12)11(2)18(20)22-17(14)19-16/h3-9H,1-2H3
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4SC AG

US Patent


Assay Description
For a description of a Kv1.3 patch-clamp assay, see Grissmer et al., Mol. Pharmacol. 1994, 45, 1227; whole cell patch-clamp recording was performed w...


US Patent US10399991 (2019)


BindingDB Entry DOI: 10.7270/Q2SJ1P0X
More data for this
Ligand-Target Pair
Voltage-gated potassium channel


(Homo sapiens (Human))
BDBM412943
PNG
(US10399991, Example 60 | US10822345, Ex 60)
Show SMILES Cc1coc2c(C)c3n(C)c(=O)c(C)c(-c4ccccc4Cl)c3cc12
Show InChI InChI=1S/C21H18ClNO2/c1-11-10-25-20-13(3)19-16(9-15(11)20)18(12(2)21(24)23(19)4)14-7-5-6-8-17(14)22/h5-10H,1-4H3
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4SC AG

US Patent


Assay Description
For a description of a Kv1.3 patch-clamp assay, see Grissmer et al., Mol. Pharmacol. 1994, 45, 1227; whole cell patch-clamp recording was performed w...


US Patent US10399991 (2019)


BindingDB Entry DOI: 10.7270/Q2SJ1P0X
More data for this
Ligand-Target Pair
Voltage-gated potassium channel


(Homo sapiens (Human))
BDBM412884
PNG
(US10399991, Example 1 | US10822345, Ex 1)
Show SMILES COc1ccccc1-c1cc(=O)oc2c(C)c3occ(C)c3cc12
Show InChI InChI=1S/C20H16O4/c1-11-10-23-19-12(2)20-16(8-14(11)19)15(9-18(21)24-20)13-6-4-5-7-17(13)22-3/h4-10H,1-3H3
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4SC AG

US Patent


Assay Description
For a description of a Kv1.3 patch-clamp assay, see Grissmer et al., Mol. Pharmacol. 1994, 45, 1227; whole cell patch-clamp recording was performed w...


US Patent US10399991 (2019)


BindingDB Entry DOI: 10.7270/Q2SJ1P0X
More data for this
Ligand-Target Pair
Voltage-gated potassium channel


(Homo sapiens (Human))
BDBM412913
PNG
(US10399991, Example 30 | US10822345, Ex 30)
Show SMILES Cc1coc2c(C)c3[nH]c(=O)c(C)c(-c4ccccc4F)c3cc12
Show InChI InChI=1S/C20H16FNO2/c1-10-9-24-19-12(3)18-15(8-14(10)19)17(11(2)20(23)22-18)13-6-4-5-7-16(13)21/h4-9H,1-3H3,(H,22,23)
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4SC AG

US Patent


Assay Description
For a description of a Kv1.3 patch-clamp assay, see Grissmer et al., Mol. Pharmacol. 1994, 45, 1227; whole cell patch-clamp recording was performed w...


US Patent US10399991 (2019)


BindingDB Entry DOI: 10.7270/Q2SJ1P0X
More data for this
Ligand-Target Pair
Voltage-gated potassium channel


(Homo sapiens (Human))
BDBM412899
PNG
(US10399991, Example 16 | US10822345, Ex 16)
Show SMILES CCc1coc2c(C)c3oc(=O)c(C)c(-c4ccccc4)c3cc12
Show InChI InChI=1S/C21H18O3/c1-4-14-11-23-19-13(3)20-17(10-16(14)19)18(12(2)21(22)24-20)15-8-6-5-7-9-15/h5-11H,4H2,1-3H3
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Assay Description
For a description of a Kv1.3 patch-clamp assay, see Grissmer et al., Mol. Pharmacol. 1994, 45, 1227; whole cell patch-clamp recording was performed w...


US Patent US10399991 (2019)


BindingDB Entry DOI: 10.7270/Q2SJ1P0X
More data for this
Ligand-Target Pair
Voltage-gated potassium channel


(Homo sapiens (Human))
BDBM412916
PNG
(US10399991, Example 33 | US10822345, Ex 33)
Show SMILES Cc1coc2c(C)c3n(C)c(=O)c(Br)c(-c4ccccc4)c3cc12
Show InChI InChI=1S/C20H16BrNO2/c1-11-10-24-19-12(2)18-15(9-14(11)19)16(13-7-5-4-6-8-13)17(21)20(23)22(18)3/h4-10H,1-3H3
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4SC AG

US Patent


Assay Description
For a description of a Kv1.3 patch-clamp assay, see Grissmer et al., Mol. Pharmacol. 1994, 45, 1227; whole cell patch-clamp recording was performed w...


US Patent US10399991 (2019)


BindingDB Entry DOI: 10.7270/Q2SJ1P0X
More data for this
Ligand-Target Pair
Voltage-gated potassium channel


(Homo sapiens (Human))
BDBM412891
PNG
(US10399991, Example 8 | US10822345, Ex 8)
Show SMILES Cc1coc2c(C)c3oc(=O)cc(-c4ccccc4F)c3cc12
Show InChI InChI=1S/C19H13FO3/c1-10-9-22-18-11(2)19-15(7-13(10)18)14(8-17(21)23-19)12-5-3-4-6-16(12)20/h3-9H,1-2H3
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4SC AG

US Patent


Assay Description
For a description of a Kv1.3 patch-clamp assay, see Grissmer et al., Mol. Pharmacol. 1994, 45, 1227; whole cell patch-clamp recording was performed w...


US Patent US10399991 (2019)


BindingDB Entry DOI: 10.7270/Q2SJ1P0X
More data for this
Ligand-Target Pair
Voltage-gated potassium channel


(Homo sapiens (Human))
BDBM412932
PNG
(US10399991, Example 49 | US10822345, Ex 49)
Show SMILES Cc1coc2nc3n(C)c(=O)c(C)c(-c4ccccc4)c3cc12
Show InChI InChI=1S/C19H16N2O2/c1-11-10-23-18-14(11)9-15-16(13-7-5-4-6-8-13)12(2)19(22)21(3)17(15)20-18/h4-10H,1-3H3
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4SC AG

US Patent


Assay Description
For a description of a Kv1.3 patch-clamp assay, see Grissmer et al., Mol. Pharmacol. 1994, 45, 1227; whole cell patch-clamp recording was performed w...


US Patent US10399991 (2019)


BindingDB Entry DOI: 10.7270/Q2SJ1P0X
More data for this
Ligand-Target Pair
Voltage-gated potassium channel


(Homo sapiens (Human))
BDBM412892
PNG
(US10399991, Example 9 | US10822345, Ex 9)
Show SMILES Cc1coc2c(C)c3oc(=O)c(C)c(-c4ccccc4)c3cc12
Show InChI InChI=1S/C20H16O3/c1-11-10-22-18-13(3)19-16(9-15(11)18)17(12(2)20(21)23-19)14-7-5-4-6-8-14/h4-10H,1-3H3
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4SC AG

US Patent


Assay Description
For a description of a Kv1.3 patch-clamp assay, see Grissmer et al., Mol. Pharmacol. 1994, 45, 1227; whole cell patch-clamp recording was performed w...


US Patent US10399991 (2019)


BindingDB Entry DOI: 10.7270/Q2SJ1P0X
More data for this
Ligand-Target Pair
Voltage-gated potassium channel


(Homo sapiens (Human))
BDBM412894
PNG
(US10399991, Example 11 | US10822345, Ex 11)
Show SMILES Cc1coc2c(C)c3oc(=O)c(C)c(-c4ccccc4Cl)c3cc12
Show InChI InChI=1S/C20H15ClO3/c1-10-9-23-18-12(3)19-15(8-14(10)18)17(11(2)20(22)24-19)13-6-4-5-7-16(13)21/h4-9H,1-3H3
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4SC AG

US Patent


Assay Description
For a description of a Kv1.3 patch-clamp assay, see Grissmer et al., Mol. Pharmacol. 1994, 45, 1227; whole cell patch-clamp recording was performed w...


US Patent US10399991 (2019)


BindingDB Entry DOI: 10.7270/Q2SJ1P0X
More data for this
Ligand-Target Pair
Voltage-gated potassium channel


(Homo sapiens (Human))
BDBM412914
PNG
(US10399991, Example 31 | US10822345, Ex 31)
Show SMILES Cc1coc2c(C)c3[nH]c(=O)c(C)c(-c4ccccc4)c3cc12
Show InChI InChI=1S/C20H17NO2/c1-11-10-23-19-13(3)18-16(9-15(11)19)17(12(2)20(22)21-18)14-7-5-4-6-8-14/h4-10H,1-3H3,(H,21,22)
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4SC AG

US Patent


Assay Description
For a description of a Kv1.3 patch-clamp assay, see Grissmer et al., Mol. Pharmacol. 1994, 45, 1227; whole cell patch-clamp recording was performed w...


US Patent US10399991 (2019)


BindingDB Entry DOI: 10.7270/Q2SJ1P0X
More data for this
Ligand-Target Pair
Voltage-gated potassium channel


(Homo sapiens (Human))
BDBM412924
PNG
(US10399991, Example 41 | US10822345, Ex 41)
Show SMILES Cc1c2occ(C3CC3)c2cc2c(cc(=O)oc12)-c1ccccc1
Show InChI InChI=1S/C21H16O3/c1-12-20-17(18(11-23-20)14-7-8-14)9-16-15(10-19(22)24-21(12)16)13-5-3-2-4-6-13/h2-6,9-11,14H,7-8H2,1H3
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US Patent


Assay Description
For a description of a Kv1.3 patch-clamp assay, see Grissmer et al., Mol. Pharmacol. 1994, 45, 1227; whole cell patch-clamp recording was performed w...


US Patent US10399991 (2019)


BindingDB Entry DOI: 10.7270/Q2SJ1P0X
More data for this
Ligand-Target Pair
Voltage-gated potassium channel


(Homo sapiens (Human))
BDBM412942
PNG
(US10399991, Example 59 | US10822345, Ex 59)
Show SMILES Cc1coc2c(C)c3n(C)c(=O)c(C)c(-c4ccccc4C)c3cc12
Show InChI InChI=1S/C22H21NO2/c1-12-8-6-7-9-16(12)19-14(3)22(24)23(5)20-15(4)21-17(10-18(19)20)13(2)11-25-21/h6-11H,1-5H3
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US Patent


Assay Description
For a description of a Kv1.3 patch-clamp assay, see Grissmer et al., Mol. Pharmacol. 1994, 45, 1227; whole cell patch-clamp recording was performed w...


US Patent US10399991 (2019)


BindingDB Entry DOI: 10.7270/Q2SJ1P0X
More data for this
Ligand-Target Pair
Voltage-gated potassium channel


(Homo sapiens (Human))
BDBM412945
PNG
(US10399991, Example 62 | US10822345, Ex 64)
Show SMILES COc1ncccc1-c1c(C)c(=O)oc2c(C)c3occ(C)c3cc12
Show InChI InChI=1S/C20H17NO4/c1-10-9-24-17-12(3)18-15(8-14(10)17)16(11(2)20(22)25-18)13-6-5-7-21-19(13)23-4/h5-9H,1-4H3
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4SC AG

US Patent


Assay Description
For a description of a Kv1.3 patch-clamp assay, see Grissmer et al., Mol. Pharmacol. 1994, 45, 1227; whole cell patch-clamp recording was performed w...


US Patent US10399991 (2019)


BindingDB Entry DOI: 10.7270/Q2SJ1P0X
More data for this
Ligand-Target Pair
Voltage-gated potassium channel


(Homo sapiens (Human))
BDBM412904
PNG
(US10399991, Example 21 | US10822345, Ex 21)
Show SMILES Cc1coc2cc3oc(=O)cc(-c4ccccc4Cl)c3cc12
Show InChI InChI=1S/C18H11ClO3/c1-10-9-21-16-8-17-14(6-12(10)16)13(7-18(20)22-17)11-4-2-3-5-15(11)19/h2-9H,1H3
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4SC AG

US Patent


Assay Description
For a description of a Kv1.3 patch-clamp assay, see Grissmer et al., Mol. Pharmacol. 1994, 45, 1227; whole cell patch-clamp recording was performed w...


US Patent US10399991 (2019)


BindingDB Entry DOI: 10.7270/Q2SJ1P0X
More data for this
Ligand-Target Pair
Voltage-gated potassium channel


(Homo sapiens (Human))
BDBM412900
PNG
(US10399991, Example 17 | US10822345, Ex 17)
Show SMILES Cc1coc2cc3oc(=O)cc(-c4ccccc4C)c3cc12
Show InChI InChI=1S/C19H14O3/c1-11-5-3-4-6-13(11)15-8-19(20)22-18-9-17-14(7-16(15)18)12(2)10-21-17/h3-10H,1-2H3
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US Patent


Assay Description
For a description of a Kv1.3 patch-clamp assay, see Grissmer et al., Mol. Pharmacol. 1994, 45, 1227; whole cell patch-clamp recording was performed w...


US Patent US10399991 (2019)


BindingDB Entry DOI: 10.7270/Q2SJ1P0X
More data for this
Ligand-Target Pair
Voltage-gated potassium channel


(Homo sapiens (Human))
BDBM412918
PNG
(US10399991, Example 35 | US10822345, Ex 35)
Show SMILES Cc1noc2c(C)c3oc(=O)c(C)c(-c4ccccc4)c3cc12
Show InChI InChI=1S/C19H15NO3/c1-10-16(13-7-5-4-6-8-13)15-9-14-12(3)20-23-18(14)11(2)17(15)22-19(10)21/h4-9H,1-3H3
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US Patent


Assay Description
For a description of a Kv1.3 patch-clamp assay, see Grissmer et al., Mol. Pharmacol. 1994, 45, 1227; whole cell patch-clamp recording was performed w...


US Patent US10399991 (2019)


BindingDB Entry DOI: 10.7270/Q2SJ1P0X
More data for this
Ligand-Target Pair
Voltage-gated potassium channel


(Homo sapiens (Human))
BDBM412903
PNG
(US10399991, Example 20 | US10822345, Ex 20)
Show SMILES COc1cccc(c1)-c1cc(=O)oc2cc3occ(C)c3cc12
Show InChI InChI=1S/C19H14O4/c1-11-10-22-17-9-18-16(7-14(11)17)15(8-19(20)23-18)12-4-3-5-13(6-12)21-2/h3-10H,1-2H3
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US Patent


Assay Description
For a description of a Kv1.3 patch-clamp assay, see Grissmer et al., Mol. Pharmacol. 1994, 45, 1227; whole cell patch-clamp recording was performed w...


US Patent US10399991 (2019)


BindingDB Entry DOI: 10.7270/Q2SJ1P0X
More data for this
Ligand-Target Pair
Voltage-gated potassium channel


(Homo sapiens (Human))
BDBM412911
PNG
(US10399991, Example 28 | US10822345, Ex 28)
Show SMILES Cc1coc2c(C)c3[nH]c(=O)c(Br)c(-c4ccccc4C)c3cc12
Show InChI InChI=1S/C20H16BrNO2/c1-10-6-4-5-7-13(10)16-15-8-14-11(2)9-24-19(14)12(3)18(15)22-20(23)17(16)21/h4-9H,1-3H3,(H,22,23)
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US Patent


Assay Description
For a description of a Kv1.3 patch-clamp assay, see Grissmer et al., Mol. Pharmacol. 1994, 45, 1227; whole cell patch-clamp recording was performed w...


US Patent US10399991 (2019)


BindingDB Entry DOI: 10.7270/Q2SJ1P0X
More data for this
Ligand-Target Pair
Voltage-gated potassium channel


(Homo sapiens (Human))
BDBM412920
PNG
(US10399991, Example 37 | US10822345, Ex 37)
Show SMILES Cc1csc2c(C)c3oc(=O)cc(-c4ccccc4)c3cc12
Show InChI InChI=1S/C19H14O2S/c1-11-10-22-19-12(2)18-16(8-14(11)19)15(9-17(20)21-18)13-6-4-3-5-7-13/h3-10H,1-2H3
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US Patent


Assay Description
For a description of a Kv1.3 patch-clamp assay, see Grissmer et al., Mol. Pharmacol. 1994, 45, 1227; whole cell patch-clamp recording was performed w...


US Patent US10399991 (2019)


BindingDB Entry DOI: 10.7270/Q2SJ1P0X
More data for this
Ligand-Target Pair
Voltage-gated potassium channel


(Homo sapiens (Human))
BDBM412921
PNG
(US10399991, Example 38 | US10822345, Ex 38)
Show SMILES Cc1nc2cc3c(cc(=O)oc3c(C)c2o1)-c1ccccc1
Show InChI InChI=1S/C18H13NO3/c1-10-17-14(8-15-18(10)21-11(2)19-15)13(9-16(20)22-17)12-6-4-3-5-7-12/h3-9H,1-2H3
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US Patent


Assay Description
For a description of a Kv1.3 patch-clamp assay, see Grissmer et al., Mol. Pharmacol. 1994, 45, 1227; whole cell patch-clamp recording was performed w...


US Patent US10399991 (2019)


BindingDB Entry DOI: 10.7270/Q2SJ1P0X
More data for this
Ligand-Target Pair
Voltage-gated potassium channel


(Homo sapiens (Human))
BDBM412907
PNG
(US10399991, Example 24 | US10822345, Ex 24)
Show SMILES Cc1coc2nc3oc(=O)cc(-c4ccccc4)c3cc12
Show InChI InChI=1S/C17H11NO3/c1-10-9-20-16-12(10)7-14-13(11-5-3-2-4-6-11)8-15(19)21-17(14)18-16/h2-9H,1H3
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US Patent


Assay Description
For a description of a Kv1.3 patch-clamp assay, see Grissmer et al., Mol. Pharmacol. 1994, 45, 1227; whole cell patch-clamp recording was performed w...


US Patent US10399991 (2019)


BindingDB Entry DOI: 10.7270/Q2SJ1P0X
More data for this
Ligand-Target Pair
Voltage-gated potassium channel


(Homo sapiens (Human))
BDBM412889
PNG
(US10399991, Example 6 | US10822345, Ex 6)
Show SMILES COc1cccc(c1)-c1c(C)c(=O)oc2c(C)c3occ(C)c3cc12
Show InChI InChI=1S/C21H18O4/c1-11-10-24-19-13(3)20-17(9-16(11)19)18(12(2)21(22)25-20)14-6-5-7-15(8-14)23-4/h5-10H,1-4H3
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US Patent


Assay Description
For a description of a Kv1.3 patch-clamp assay, see Grissmer et al., Mol. Pharmacol. 1994, 45, 1227; whole cell patch-clamp recording was performed w...


US Patent US10399991 (2019)


BindingDB Entry DOI: 10.7270/Q2SJ1P0X
More data for this
Ligand-Target Pair
Voltage-gated potassium channel


(Homo sapiens (Human))
BDBM412931
PNG
(US10399991, Example 48 | US10822345, Ex 48)
Show SMILES Cc1nc2cc3c(-c4ccccc4)c(C)c(=O)oc3c(C)c2o1
Show InChI InChI=1S/C19H15NO3/c1-10-16(13-7-5-4-6-8-13)14-9-15-18(22-12(3)20-15)11(2)17(14)23-19(10)21/h4-9H,1-3H3
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US Patent


Assay Description
For a description of a Kv1.3 patch-clamp assay, see Grissmer et al., Mol. Pharmacol. 1994, 45, 1227; whole cell patch-clamp recording was performed w...


US Patent US10399991 (2019)


BindingDB Entry DOI: 10.7270/Q2SJ1P0X
More data for this
Ligand-Target Pair
Voltage-gated potassium channel


(Homo sapiens (Human))
BDBM412938
PNG
(US10399991, Example 55 | US10822345, Ex 55)
Show SMILES Cc1coc2c(C)c3n(C)c(=O)c(C)c(-c4cccnc4)c3cc12
Show InChI InChI=1S/C20H18N2O2/c1-11-10-24-19-13(3)18-16(8-15(11)19)17(12(2)20(23)22(18)4)14-6-5-7-21-9-14/h5-10H,1-4H3
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US Patent


Assay Description
For a description of a Kv1.3 patch-clamp assay, see Grissmer et al., Mol. Pharmacol. 1994, 45, 1227; whole cell patch-clamp recording was performed w...


US Patent US10399991 (2019)


BindingDB Entry DOI: 10.7270/Q2SJ1P0X
More data for this
Ligand-Target Pair
Voltage-gated potassium channel


(Homo sapiens (Human))
BDBM412941
PNG
(US10399991, Example 58 | US10822345, Ex 58)
Show SMILES Cc1coc2c(C)c3oc(=O)cc(-c4ccccc4C)c3cc12
Show InChI InChI=1S/C20H16O3/c1-11-6-4-5-7-14(11)16-9-18(21)23-20-13(3)19-15(8-17(16)20)12(2)10-22-19/h4-10H,1-3H3
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US Patent


Assay Description
For a description of a Kv1.3 patch-clamp assay, see Grissmer et al., Mol. Pharmacol. 1994, 45, 1227; whole cell patch-clamp recording was performed w...


US Patent US10399991 (2019)


BindingDB Entry DOI: 10.7270/Q2SJ1P0X
More data for this
Ligand-Target Pair
Voltage-gated potassium channel


(Homo sapiens (Human))
BDBM412925
PNG
(US10399991, Example 42 | US10822345, Ex 42)
Show SMILES Cc1c(-c2ccccc2)c2cc3c(coc3c(C)c2oc1=O)C1CC1
Show InChI InChI=1S/C22H18O3/c1-12-19(15-6-4-3-5-7-15)17-10-16-18(14-8-9-14)11-24-20(16)13(2)21(17)25-22(12)23/h3-7,10-11,14H,8-9H2,1-2H3
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US Patent


Assay Description
For a description of a Kv1.3 patch-clamp assay, see Grissmer et al., Mol. Pharmacol. 1994, 45, 1227; whole cell patch-clamp recording was performed w...


US Patent US10399991 (2019)


BindingDB Entry DOI: 10.7270/Q2SJ1P0X
More data for this
Ligand-Target Pair
Voltage-gated potassium channel


(Homo sapiens (Human))
BDBM412901
PNG
(US10399991, Example 18 | US10822345, Ex 18)
Show SMILES Cc1coc2cc3oc(=O)cc(-c4cccc(C)c4)c3cc12
Show InChI InChI=1S/C19H14O3/c1-11-4-3-5-13(6-11)15-8-19(20)22-18-9-17-14(7-16(15)18)12(2)10-21-17/h3-10H,1-2H3
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US Patent


Assay Description
For a description of a Kv1.3 patch-clamp assay, see Grissmer et al., Mol. Pharmacol. 1994, 45, 1227; whole cell patch-clamp recording was performed w...


US Patent US10399991 (2019)


BindingDB Entry DOI: 10.7270/Q2SJ1P0X
More data for this
Ligand-Target Pair
Voltage-gated potassium channel


(Homo sapiens (Human))
BDBM412902
PNG
(US10399991, Example 19 | US10822345, Ex 19)
Show SMILES COc1ccccc1-c1cc(=O)oc2cc3occ(C)c3cc12
Show InChI InChI=1S/C19H14O4/c1-11-10-22-17-9-18-15(7-13(11)17)14(8-19(20)23-18)12-5-3-4-6-16(12)21-2/h3-10H,1-2H3
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US Patent


Assay Description
For a description of a Kv1.3 patch-clamp assay, see Grissmer et al., Mol. Pharmacol. 1994, 45, 1227; whole cell patch-clamp recording was performed w...


US Patent US10399991 (2019)


BindingDB Entry DOI: 10.7270/Q2SJ1P0X
More data for this
Ligand-Target Pair
Voltage-gated potassium channel


(Homo sapiens (Human))
BDBM412905
PNG
(US10399991, Example 22 | US10822345, Ex 22)
Show SMILES Cc1coc2cc3oc(=O)cc(-c4cccc(Cl)c4)c3cc12
Show InChI InChI=1S/C18H11ClO3/c1-10-9-21-16-8-17-15(6-13(10)16)14(7-18(20)22-17)11-3-2-4-12(19)5-11/h2-9H,1H3
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US Patent


Assay Description
For a description of a Kv1.3 patch-clamp assay, see Grissmer et al., Mol. Pharmacol. 1994, 45, 1227; whole cell patch-clamp recording was performed w...


US Patent US10399991 (2019)


BindingDB Entry DOI: 10.7270/Q2SJ1P0X
More data for this
Ligand-Target Pair
Voltage-gated potassium channel


(Homo sapiens (Human))
BDBM412935
PNG
(US10399991, Example 52 | US10822345, Ex 52)
Show SMILES Cc1noc2c(C)c3n(C)c(=O)c(C)c(-c4ccccc4)c3cc12
Show InChI InChI=1S/C20H18N2O2/c1-11-17(14-8-6-5-7-9-14)16-10-15-13(3)21-24-19(15)12(2)18(16)22(4)20(11)23/h5-10H,1-4H3
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US Patent


Assay Description
For a description of a Kv1.3 patch-clamp assay, see Grissmer et al., Mol. Pharmacol. 1994, 45, 1227; whole cell patch-clamp recording was performed w...


US Patent US10399991 (2019)


BindingDB Entry DOI: 10.7270/Q2SJ1P0X
More data for this
Ligand-Target Pair
Voltage-gated potassium channel


(Homo sapiens (Human))
BDBM412934
PNG
(US10399991, Example 51 | US10822345, Ex 51)
Show SMILES Cc1noc2c(C)c3[nH]c(=O)cc(-c4ccccc4)c3cc12
Show InChI InChI=1S/C18H14N2O2/c1-10-17-15(8-13-11(2)20-22-18(10)13)14(9-16(21)19-17)12-6-4-3-5-7-12/h3-9H,1-2H3,(H,19,21)
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US Patent


Assay Description
For a description of a Kv1.3 patch-clamp assay, see Grissmer et al., Mol. Pharmacol. 1994, 45, 1227; whole cell patch-clamp recording was performed w...


US Patent US10399991 (2019)


BindingDB Entry DOI: 10.7270/Q2SJ1P0X
More data for this
Ligand-Target Pair
Voltage-gated potassium channel


(Homo sapiens (Human))
BDBM412910
PNG
(US10399991, Example 27 | US10822345, Ex 27)
Show SMILES Cc1coc2c(C)c3[nH]c(=O)c(Br)c(-c4ccccc4F)c3cc12
Show InChI InChI=1S/C19H13BrFNO2/c1-9-8-24-18-10(2)17-13(7-12(9)18)15(16(20)19(23)22-17)11-5-3-4-6-14(11)21/h3-8H,1-2H3,(H,22,23)
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US Patent


Assay Description
For a description of a Kv1.3 patch-clamp assay, see Grissmer et al., Mol. Pharmacol. 1994, 45, 1227; whole cell patch-clamp recording was performed w...


US Patent US10399991 (2019)


BindingDB Entry DOI: 10.7270/Q2SJ1P0X
More data for this
Ligand-Target Pair
Voltage-gated potassium channel


(Homo sapiens (Human))
BDBM412947
PNG
(US10399991, Example 64)
Show SMILES COc1ncccc1-c1c(C)c(=O)n(C)c2c(C)c3occ(C)c3cc12
Show InChI InChI=1S/C21H20N2O3/c1-11-10-26-19-13(3)18-16(9-15(11)19)17(12(2)21(24)23(18)4)14-7-6-8-22-20(14)25-5/h6-10H,1-5H3
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US Patent


Assay Description
For a description of a Kv1.3 patch-clamp assay, see Grissmer et al., Mol. Pharmacol. 1994, 45, 1227; whole cell patch-clamp recording was performed w...


US Patent US10399991 (2019)


BindingDB Entry DOI: 10.7270/Q2SJ1P0X
More data for this
Ligand-Target Pair
Voltage-gated potassium channel


(Homo sapiens (Human))
BDBM412933
PNG
(US10399991, Example 50 | US10822345, Ex 50)
Show SMILES Cc1noc2c(C)c3oc(=O)cc(-c4ccccc4)c3cc12
Show InChI InChI=1S/C18H13NO3/c1-10-17-15(8-13-11(2)19-22-18(10)13)14(9-16(20)21-17)12-6-4-3-5-7-12/h3-9H,1-2H3
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Assay Description
For a description of a Kv1.3 patch-clamp assay, see Grissmer et al., Mol. Pharmacol. 1994, 45, 1227; whole cell patch-clamp recording was performed w...


US Patent US10399991 (2019)


BindingDB Entry DOI: 10.7270/Q2SJ1P0X
More data for this
Ligand-Target Pair
Voltage-gated potassium channel


(Homo sapiens (Human))
BDBM412927
PNG
(US10399991, Example 44 | US10822345, Ex 44)
Show SMILES Cc1coc2c(C)c3oc(=O)cc(-c4cccnc4)c3cc12
Show InChI InChI=1S/C18H13NO3/c1-10-9-21-17-11(2)18-15(6-13(10)17)14(7-16(20)22-18)12-4-3-5-19-8-12/h3-9H,1-2H3
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Assay Description
For a description of a Kv1.3 patch-clamp assay, see Grissmer et al., Mol. Pharmacol. 1994, 45, 1227; whole cell patch-clamp recording was performed w...


US Patent US10399991 (2019)


BindingDB Entry DOI: 10.7270/Q2SJ1P0X
More data for this
Ligand-Target Pair
Voltage-gated potassium channel


(Homo sapiens (Human))
BDBM412896
PNG
(US10399991, Example 13 | US10822345, Ex 13)
Show SMILES Cc1c(oc2c(C)c3oc(=O)cc(-c4ccccc4)c3cc12)C#N
Show InChI InChI=1S/C20H13NO3/c1-11-14-8-16-15(13-6-4-3-5-7-13)9-18(22)24-20(16)12(2)19(14)23-17(11)10-21/h3-9H,1-2H3
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4SC AG

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Assay Description
For a description of a Kv1.3 patch-clamp assay, see Grissmer et al., Mol. Pharmacol. 1994, 45, 1227; whole cell patch-clamp recording was performed w...


US Patent US10399991 (2019)


BindingDB Entry DOI: 10.7270/Q2SJ1P0X
More data for this
Ligand-Target Pair
Voltage-gated potassium channel


(Homo sapiens (Human))
BDBM412929
PNG
(US10399991, Example 46 | US10822345, Ex 46)
Show SMILES CN(C)Cc1oc2c(C)c3oc(=O)c(C)c(-c4ccccc4)c3cc2c1C
Show InChI InChI=1S/C23H23NO3/c1-13-17-11-18-20(16-9-7-6-8-10-16)14(2)23(25)27-22(18)15(3)21(17)26-19(13)12-24(4)5/h6-11H,12H2,1-5H3
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Assay Description
For a description of a Kv1.3 patch-clamp assay, see Grissmer et al., Mol. Pharmacol. 1994, 45, 1227; whole cell patch-clamp recording was performed w...


US Patent US10399991 (2019)


BindingDB Entry DOI: 10.7270/Q2SJ1P0X
More data for this
Ligand-Target Pair
Voltage-gated potassium channel


(Homo sapiens (Human))
BDBM412928
PNG
(US10399991, Example 45 | US10822345, Ex 45)
Show SMILES Cc1c(oc2c(C)c3oc(=O)c(C)c(-c4ccccc4)c3cc12)C#N
Show InChI InChI=1S/C21H15NO3/c1-11-15-9-16-18(14-7-5-4-6-8-14)12(2)21(23)25-20(16)13(3)19(15)24-17(11)10-22/h4-9H,1-3H3
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Assay Description
For a description of a Kv1.3 patch-clamp assay, see Grissmer et al., Mol. Pharmacol. 1994, 45, 1227; whole cell patch-clamp recording was performed w...


US Patent US10399991 (2019)


BindingDB Entry DOI: 10.7270/Q2SJ1P0X
More data for this
Ligand-Target Pair
Voltage-gated potassium channel


(Homo sapiens (Human))
BDBM412887
PNG
(US10399991, Example 4 | US10822345, Ex 4)
Show SMILES Cc1coc2c(C)c3oc(=O)cc(-c4cccc(c4)C(F)(F)F)c3cc12
Show InChI InChI=1S/C20H13F3O3/c1-10-9-25-18-11(2)19-16(7-14(10)18)15(8-17(24)26-19)12-4-3-5-13(6-12)20(21,22)23/h3-9H,1-2H3
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Assay Description
For a description of a Kv1.3 patch-clamp assay, see Grissmer et al., Mol. Pharmacol. 1994, 45, 1227; whole cell patch-clamp recording was performed w...


US Patent US10399991 (2019)


BindingDB Entry DOI: 10.7270/Q2SJ1P0X
More data for this
Ligand-Target Pair
Voltage-gated potassium channel


(Homo sapiens (Human))
BDBM412946
PNG
(US10399991, Example 63 | US10822345, Ex 63)
Show SMILES COc1ccncc1-c1c(C)c(=O)oc2c(C)c3occ(C)c3cc12
Show InChI InChI=1S/C20H17NO4/c1-10-9-24-18-12(3)19-14(7-13(10)18)17(11(2)20(22)25-19)15-8-21-6-5-16(15)23-4/h5-9H,1-4H3
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Assay Description
For a description of a Kv1.3 patch-clamp assay, see Grissmer et al., Mol. Pharmacol. 1994, 45, 1227; whole cell patch-clamp recording was performed w...


US Patent US10399991 (2019)


BindingDB Entry DOI: 10.7270/Q2SJ1P0X
More data for this
Ligand-Target Pair
Voltage-gated potassium channel


(Homo sapiens (Human))
BDBM412930
PNG
(US10399991, Example 47 | US10822345, Ex 47)
Show SMILES Cc1c2ocnc2cc2c(cc(=O)oc12)-c1ccccc1
Show InChI InChI=1S/C17H11NO3/c1-10-16-13(7-14-17(10)20-9-18-14)12(8-15(19)21-16)11-5-3-2-4-6-11/h2-9H,1H3
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Assay Description
For a description of a Kv1.3 patch-clamp assay, see Grissmer et al., Mol. Pharmacol. 1994, 45, 1227; whole cell patch-clamp recording was performed w...


US Patent US10399991 (2019)


BindingDB Entry DOI: 10.7270/Q2SJ1P0X
More data for this
Ligand-Target Pair
Voltage-gated potassium channel


(Homo sapiens (Human))
BDBM412922
PNG
(US10399991, Example 39 | US10822345, Ex 39)
Show SMILES CNCc1nc2cc3c(cc(=O)oc3c(C)c2o1)-c1ccccc1
Show InChI InChI=1S/C19H16N2O3/c1-11-18-14(8-15-19(11)23-16(21-15)10-20-2)13(9-17(22)24-18)12-6-4-3-5-7-12/h3-9,20H,10H2,1-2H3
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Assay Description
For a description of a Kv1.3 patch-clamp assay, see Grissmer et al., Mol. Pharmacol. 1994, 45, 1227; whole cell patch-clamp recording was performed w...


US Patent US10399991 (2019)


BindingDB Entry DOI: 10.7270/Q2SJ1P0X
More data for this
Ligand-Target Pair
Voltage-gated potassium channel


(Homo sapiens (Human))
BDBM412912
PNG
(US10399991, Example 29 | US10822345, Ex 29)
Show SMILES Cc1coc2c(C)c3[nH]c(=O)cc(-c4ccccc4C)c3cc12
Show InChI InChI=1S/C20H17NO2/c1-11-6-4-5-7-14(11)16-9-18(22)21-19-13(3)20-15(8-17(16)19)12(2)10-23-20/h4-10H,1-3H3,(H,21,22)
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Assay Description
For a description of a Kv1.3 patch-clamp assay, see Grissmer et al., Mol. Pharmacol. 1994, 45, 1227; whole cell patch-clamp recording was performed w...


US Patent US10399991 (2019)


BindingDB Entry DOI: 10.7270/Q2SJ1P0X
More data for this
Ligand-Target Pair
Voltage-gated potassium channel


(Homo sapiens (Human))
BDBM412940
PNG
(US10399991, Example 57 | US10822345, Ex 57)
Show SMILES Cc1coc2c(C)c3oc(=O)cc(-c4ccccn4)c3cc12
Show InChI InChI=1S/C18H13NO3/c1-10-9-21-17-11(2)18-14(7-12(10)17)13(8-16(20)22-18)15-5-3-4-6-19-15/h3-9H,1-2H3
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Assay Description
For a description of a Kv1.3 patch-clamp assay, see Grissmer et al., Mol. Pharmacol. 1994, 45, 1227; whole cell patch-clamp recording was performed w...


US Patent US10399991 (2019)


BindingDB Entry DOI: 10.7270/Q2SJ1P0X
More data for this
Ligand-Target Pair
Voltage-gated potassium channel


(Homo sapiens (Human))
BDBM412915
PNG
(US10399991, Example 32 | US10822345, Ex 32)
Show SMILES Cc1coc2c(C)c3n(C)c(=O)cc(-c4ccccc4)c3cc12
Show InChI InChI=1S/C20H17NO2/c1-12-11-23-20-13(2)19-17(9-15(12)20)16(10-18(22)21(19)3)14-7-5-4-6-8-14/h4-11H,1-3H3
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US Patent


Assay Description
For a description of a Kv1.3 patch-clamp assay, see Grissmer et al., Mol. Pharmacol. 1994, 45, 1227; whole cell patch-clamp recording was performed w...


US Patent US10399991 (2019)


BindingDB Entry DOI: 10.7270/Q2SJ1P0X
More data for this
Ligand-Target Pair
Voltage-gated potassium channel


(Homo sapiens (Human))
BDBM412897
PNG
(US10399991, Example 14 | US10822345, Ex 14)
Show SMILES Cc1c(CN2CCOCC2)oc2c(C)c3oc(=O)cc(-c4ccccc4)c3cc12
Show InChI InChI=1S/C24H23NO4/c1-15-18-12-20-19(17-6-4-3-5-7-17)13-22(26)29-24(20)16(2)23(18)28-21(15)14-25-8-10-27-11-9-25/h3-7,12-13H,8-11,14H2,1-2H3
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Assay Description
For a description of a Kv1.3 patch-clamp assay, see Grissmer et al., Mol. Pharmacol. 1994, 45, 1227; whole cell patch-clamp recording was performed w...


US Patent US10399991 (2019)


BindingDB Entry DOI: 10.7270/Q2SJ1P0X
More data for this
Ligand-Target Pair
Voltage-gated potassium channel


(Homo sapiens (Human))
BDBM412895
PNG
(US10399991, Example 12 | US10822345, Ex 12)
Show SMILES Cc1c(oc2c(C)c3oc(=O)cc(-c4ccccc4)c3cc12)N1CCOCC1
Show InChI InChI=1S/C23H21NO4/c1-14-17-12-19-18(16-6-4-3-5-7-16)13-20(25)27-22(19)15(2)21(17)28-23(14)24-8-10-26-11-9-24/h3-7,12-13H,8-11H2,1-2H3
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Assay Description
For a description of a Kv1.3 patch-clamp assay, see Grissmer et al., Mol. Pharmacol. 1994, 45, 1227; whole cell patch-clamp recording was performed w...


US Patent US10399991 (2019)


BindingDB Entry DOI: 10.7270/Q2SJ1P0X
More data for this
Ligand-Target Pair
Voltage-gated potassium channel


(Homo sapiens (Human))
BDBM412886
PNG
(US10399991, Example 3 | US10822345, Ex 3)
Show SMILES Cc1coc2c(C)c3oc(=O)cc(-c4ccccc4Cl)c3cc12
Show InChI InChI=1S/C19H13ClO3/c1-10-9-22-18-11(2)19-15(7-13(10)18)14(8-17(21)23-19)12-5-3-4-6-16(12)20/h3-9H,1-2H3
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Assay Description
For a description of a Kv1.3 patch-clamp assay, see Grissmer et al., Mol. Pharmacol. 1994, 45, 1227; whole cell patch-clamp recording was performed w...


US Patent US10399991 (2019)


BindingDB Entry DOI: 10.7270/Q2SJ1P0X
More data for this
Ligand-Target Pair
Voltage-gated potassium channel


(Homo sapiens (Human))
BDBM412885
PNG
(US10399991, Example 2 | US10822345, Ex 2)
Show SMILES COc1cccc(c1)-c1cc(=O)oc2c(C)c3occ(C)c3cc12
Show InChI InChI=1S/C20H16O4/c1-11-10-23-19-12(2)20-17(8-15(11)19)16(9-18(21)24-20)13-5-4-6-14(7-13)22-3/h4-10H,1-3H3
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Assay Description
For a description of a Kv1.3 patch-clamp assay, see Grissmer et al., Mol. Pharmacol. 1994, 45, 1227; whole cell patch-clamp recording was performed w...


US Patent US10399991 (2019)


BindingDB Entry DOI: 10.7270/Q2SJ1P0X
More data for this
Ligand-Target Pair
Voltage-gated potassium channel


(Homo sapiens (Human))
BDBM412939
PNG
(US10399991, Example 56 | US10822345, Ex 56)
Show SMILES Cc1noc2c(C)c3n(C)c(=O)c(C)c(-c4cccnc4)c3cc12
Show InChI InChI=1S/C19H17N3O2/c1-10-16(13-6-5-7-20-9-13)15-8-14-12(3)21-24-18(14)11(2)17(15)22(4)19(10)23/h5-9H,1-4H3
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Assay Description
For a description of a Kv1.3 patch-clamp assay, see Grissmer et al., Mol. Pharmacol. 1994, 45, 1227; whole cell patch-clamp recording was performed w...


US Patent US10399991 (2019)


BindingDB Entry DOI: 10.7270/Q2SJ1P0X
More data for this
Ligand-Target Pair
Voltage-gated potassium channel


(Homo sapiens (Human))
BDBM412906
PNG
(US10399991, Example 23 | US10822345, Ex 23)
Show SMILES COc1c2occ(C)c2cc2c(cc(=O)oc12)-c1ccccc1
Show InChI InChI=1S/C19H14O4/c1-11-10-22-17-13(11)8-15-14(12-6-4-3-5-7-12)9-16(20)23-18(15)19(17)21-2/h3-10H,1-2H3
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Assay Description
For a description of a Kv1.3 patch-clamp assay, see Grissmer et al., Mol. Pharmacol. 1994, 45, 1227; whole cell patch-clamp recording was performed w...


US Patent US10399991 (2019)


BindingDB Entry DOI: 10.7270/Q2SJ1P0X
More data for this
Ligand-Target Pair
Voltage-gated potassium channel


(Homo sapiens (Human))
BDBM412898
PNG
(US10399991, Example 15 | US10822345, Ex 15)
Show SMILES CN(C)Cc1oc2c(C)c3oc(=O)cc(-c4ccccc4)c3cc2c1C
Show InChI InChI=1S/C22H21NO3/c1-13-16-10-18-17(15-8-6-5-7-9-15)11-20(24)26-22(18)14(2)21(16)25-19(13)12-23(3)4/h5-11H,12H2,1-4H3
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Assay Description
For a description of a Kv1.3 patch-clamp assay, see Grissmer et al., Mol. Pharmacol. 1994, 45, 1227; whole cell patch-clamp recording was performed w...


US Patent US10399991 (2019)


BindingDB Entry DOI: 10.7270/Q2SJ1P0X
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%