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Patent code US10407423

Compile Data Set for Download or QSAR
Found 40 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Protein G9a (G9a)


(Homo sapiens (Human))
BDBM413401
PNG
(US10407423, Compound 2-08)
Show SMILES COc1cc2c3NC(CC4CCN(CC4)C(C)C)CCc3c(nc2cc1OCCCN1CCCC1)-c1ccc(C)o1
Show InChI InChI=1S/C34H48N4O3/c1-23(2)38-17-12-25(13-18-38)20-26-9-10-27-33(35-26)28-21-31(39-4)32(40-19-7-16-37-14-5-6-15-37)22-29(28)36-34(27)30-11-8-24(3)41-30/h8,11,21-23,25-26,35H,5-7,9-10,12-20H2,1-4H3
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n/an/a<100n/an/an/an/an/an/a



FUNDACIÓN PARA LA INVESTIGACIÓN MÉDICA APLICADA

US Patent


Assay Description
The biochemical assay to measure G9a enzyme activity relies on time-resolved fluorescence energy transfer (TR-FRET) between europium cryptate (donor)...


US Patent US10407423 (2019)


BindingDB Entry DOI: 10.7270/Q24T6MRQ
More data for this
Ligand-Target Pair
Protein G9a (G9a)


(Homo sapiens (Human))
BDBM413405
PNG
(US10407423, Compound 2-12)
Show SMILES COc1cc2c3NC(CC4CCN(CC4)C4CCCCC4)CCc3c(nc2cc1OCCCN1CCCC1)-c1ccc(C)o1
Show InChI InChI=1S/C37H52N4O3/c1-26-11-14-33(44-26)37-30-13-12-28(23-27-15-20-41(21-16-27)29-9-4-3-5-10-29)38-36(30)31-24-34(42-2)35(25-32(31)39-37)43-22-8-19-40-17-6-7-18-40/h11,14,24-25,27-29,38H,3-10,12-13,15-23H2,1-2H3
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n/an/a<100n/an/an/an/an/an/a



FUNDACIÓN PARA LA INVESTIGACIÓN MÉDICA APLICADA

US Patent


Assay Description
The biochemical assay to measure G9a enzyme activity relies on time-resolved fluorescence energy transfer (TR-FRET) between europium cryptate (donor)...


US Patent US10407423 (2019)


BindingDB Entry DOI: 10.7270/Q24T6MRQ
More data for this
Ligand-Target Pair
Protein G9a (G9a)


(Homo sapiens (Human))
BDBM413402
PNG
(US10407423, Compound 2-09)
Show SMILES COc1cc2c3N[C@@H](CC4CCN(C)CC4)CCc3c(nc2cc1OCCCN1CCCC1)-c1ccc(C)o1
Show InChI InChI=1S/C32H44N4O3/c1-22-7-10-28(39-22)32-25-9-8-24(19-23-11-16-35(2)17-12-23)33-31(25)26-20-29(37-3)30(21-27(26)34-32)38-18-6-15-36-13-4-5-14-36/h7,10,20-21,23-24,33H,4-6,8-9,11-19H2,1-3H3/t24-/m1/s1
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FUNDACIÓN PARA LA INVESTIGACIÓN MÉDICA APLICADA

US Patent


Assay Description
The biochemical assay to measure G9a enzyme activity relies on time-resolved fluorescence energy transfer (TR-FRET) between europium cryptate (donor)...


US Patent US10407423 (2019)


BindingDB Entry DOI: 10.7270/Q24T6MRQ
More data for this
Ligand-Target Pair
Protein G9a (G9a)


(Homo sapiens (Human))
BDBM413409
PNG
(US10407423, Compound 3-03)
Show SMILES COc1cc2c(cc1OCCCN1CCCC1)nc(-c1ccc(C)o1)c1ccc(CC3CCN(C)CC3)nc21
Show InChI InChI=1S/C32H40N4O3/c1-22-7-10-28(39-22)32-25-9-8-24(19-23-11-16-35(2)17-12-23)33-31(25)26-20-29(37-3)30(21-27(26)34-32)38-18-6-15-36-13-4-5-14-36/h7-10,20-21,23H,4-6,11-19H2,1-3H3
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FUNDACIÓN PARA LA INVESTIGACIÓN MÉDICA APLICADA

US Patent


Assay Description
The biochemical assay to measure G9a enzyme activity relies on time-resolved fluorescence energy transfer (TR-FRET) between europium cryptate (donor)...


US Patent US10407423 (2019)


BindingDB Entry DOI: 10.7270/Q24T6MRQ
More data for this
Ligand-Target Pair
Protein G9a (G9a)


(Homo sapiens (Human))
BDBM413406
PNG
(US10407423, Compound 2-13)
Show SMILES COc1cc2c3NC(CC4CCN(C)CC4)CCc3c(nc2cc1OCCCN1CCCC1)-c1cc(C)oc1C
Show InChI InChI=1S/C33H46N4O3/c1-22-18-27(23(2)40-22)32-26-9-8-25(19-24-10-15-36(3)16-11-24)34-33(26)28-20-30(38-4)31(21-29(28)35-32)39-17-7-14-37-12-5-6-13-37/h18,20-21,24-25,34H,5-17,19H2,1-4H3
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FUNDACIÓN PARA LA INVESTIGACIÓN MÉDICA APLICADA

US Patent


Assay Description
The biochemical assay to measure G9a enzyme activity relies on time-resolved fluorescence energy transfer (TR-FRET) between europium cryptate (donor)...


US Patent US10407423 (2019)


BindingDB Entry DOI: 10.7270/Q24T6MRQ
More data for this
Ligand-Target Pair
Protein G9a (G9a)


(Homo sapiens (Human))
BDBM413400
PNG
(US10407423, Compound 2-07)
Show SMILES COc1cc2c3NC(CC4CCN(CC4)C4CC4)CCc3c(nc2cc1OCCCN1CCCC1)-c1ccc(C)o1
Show InChI InChI=1S/C34H46N4O3/c1-23-6-11-30(41-23)34-27-10-7-25(20-24-12-17-38(18-13-24)26-8-9-26)35-33(27)28-21-31(39-2)32(22-29(28)36-34)40-19-5-16-37-14-3-4-15-37/h6,11,21-22,24-26,35H,3-5,7-10,12-20H2,1-2H3
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FUNDACIÓN PARA LA INVESTIGACIÓN MÉDICA APLICADA

US Patent


Assay Description
The biochemical assay to measure G9a enzyme activity relies on time-resolved fluorescence energy transfer (TR-FRET) between europium cryptate (donor)...


US Patent US10407423 (2019)


BindingDB Entry DOI: 10.7270/Q24T6MRQ
More data for this
Ligand-Target Pair
Protein G9a (G9a)


(Homo sapiens (Human))
BDBM413399
PNG
(US10407423, Compound 2-06)
Show SMILES COc1cc2c3NC(CC4CCN(C)CC4)CCc3c(nc2cc1OCCCN1CCCC1)-c1ccc(C)o1
Show InChI InChI=1S/C32H44N4O3/c1-22-7-10-28(39-22)32-25-9-8-24(19-23-11-16-35(2)17-12-23)33-31(25)26-20-29(37-3)30(21-27(26)34-32)38-18-6-15-36-13-4-5-14-36/h7,10,20-21,23-24,33H,4-6,8-9,11-19H2,1-3H3
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FUNDACIÓN PARA LA INVESTIGACIÓN MÉDICA APLICADA

US Patent


Assay Description
The biochemical assay to measure G9a enzyme activity relies on time-resolved fluorescence energy transfer (TR-FRET) between europium cryptate (donor)...


US Patent US10407423 (2019)


BindingDB Entry DOI: 10.7270/Q24T6MRQ
More data for this
Ligand-Target Pair
Protein G9a (G9a)


(Homo sapiens (Human))
BDBM413396
PNG
(US10407423, Compound 2-03)
Show SMILES COc1cc2c3NCCCc3c(nc2cc1OCCCN1CCCC1)-c1ccc(C)o1
Show InChI InChI=1S/C25H31N3O3/c1-17-8-9-21(31-17)25-18-7-5-10-26-24(18)19-15-22(29-2)23(16-20(19)27-25)30-14-6-13-28-11-3-4-12-28/h8-9,15-16,26H,3-7,10-14H2,1-2H3
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FUNDACIÓN PARA LA INVESTIGACIÓN MÉDICA APLICADA

US Patent


Assay Description
The biochemical assay to measure G9a enzyme activity relies on time-resolved fluorescence energy transfer (TR-FRET) between europium cryptate (donor)...


US Patent US10407423 (2019)


BindingDB Entry DOI: 10.7270/Q24T6MRQ
More data for this
Ligand-Target Pair
Protein G9a (G9a)


(Homo sapiens (Human))
BDBM413403
PNG
(US10407423, Compound 2-10)
Show SMILES COc1cc2c3N[C@H](CC4CCN(C)CC4)CCc3c(nc2cc1OCCCN1CCCC1)-c1ccc(C)o1
Show InChI InChI=1S/C32H44N4O3/c1-22-7-10-28(39-22)32-25-9-8-24(19-23-11-16-35(2)17-12-23)33-31(25)26-20-29(37-3)30(21-27(26)34-32)38-18-6-15-36-13-4-5-14-36/h7,10,20-21,23-24,33H,4-6,8-9,11-19H2,1-3H3/t24-/m0/s1
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FUNDACIÓN PARA LA INVESTIGACIÓN MÉDICA APLICADA

US Patent


Assay Description
The biochemical assay to measure G9a enzyme activity relies on time-resolved fluorescence energy transfer (TR-FRET) between europium cryptate (donor)...


US Patent US10407423 (2019)


BindingDB Entry DOI: 10.7270/Q24T6MRQ
More data for this
Ligand-Target Pair
Protein G9a (G9a)


(Homo sapiens (Human))
BDBM413398
PNG
(US10407423, Compound 2-05)
Show SMILES COc1cc2c3NC(CC4CCNCC4)CCc3c(nc2cc1OCCCN1CCCC1)-c1ccc(C)o1
Show InChI InChI=1S/C31H42N4O3/c1-21-6-9-27(38-21)31-24-8-7-23(18-22-10-12-32-13-11-22)33-30(24)25-19-28(36-2)29(20-26(25)34-31)37-17-5-16-35-14-3-4-15-35/h6,9,19-20,22-23,32-33H,3-5,7-8,10-18H2,1-2H3
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FUNDACIÓN PARA LA INVESTIGACIÓN MÉDICA APLICADA

US Patent


Assay Description
The biochemical assay to measure G9a enzyme activity relies on time-resolved fluorescence energy transfer (TR-FRET) between europium cryptate (donor)...


US Patent US10407423 (2019)


BindingDB Entry DOI: 10.7270/Q24T6MRQ
More data for this
Ligand-Target Pair
Protein G9a (G9a)


(Homo sapiens (Human))
BDBM413404
PNG
(US10407423, Compound 2-11)
Show SMILES COc1cc2c3NC(CC4CCN(CC4)C(C)=O)CCc3c(nc2cc1OCCCN1CCCC1)-c1ccc(C)o1
Show InChI InChI=1S/C33H44N4O4/c1-22-7-10-29(41-22)33-26-9-8-25(19-24-11-16-37(17-12-24)23(2)38)34-32(26)27-20-30(39-3)31(21-28(27)35-33)40-18-6-15-36-13-4-5-14-36/h7,10,20-21,24-25,34H,4-6,8-9,11-19H2,1-3H3
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FUNDACIÓN PARA LA INVESTIGACIÓN MÉDICA APLICADA

US Patent


Assay Description
The biochemical assay to measure G9a enzyme activity relies on time-resolved fluorescence energy transfer (TR-FRET) between europium cryptate (donor)...


US Patent US10407423 (2019)


BindingDB Entry DOI: 10.7270/Q24T6MRQ
More data for this
Ligand-Target Pair
Protein G9a (G9a)


(Homo sapiens (Human))
BDBM413410
PNG
(US10407423, Compound 3-04)
Show SMILES COc1cc2c(cc1OCCCN1CCCC1)nc(-c1cc(C)oc1C)c1ccc(CC3CCN(C)CC3)nc21
Show InChI InChI=1S/C33H42N4O3/c1-22-18-27(23(2)40-22)32-26-9-8-25(19-24-10-15-36(3)16-11-24)34-33(26)28-20-30(38-4)31(21-29(28)35-32)39-17-7-14-37-12-5-6-13-37/h8-9,18,20-21,24H,5-7,10-17,19H2,1-4H3
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FUNDACIÓN PARA LA INVESTIGACIÓN MÉDICA APLICADA

US Patent


Assay Description
The biochemical assay to measure G9a enzyme activity relies on time-resolved fluorescence energy transfer (TR-FRET) between europium cryptate (donor)...


US Patent US10407423 (2019)


BindingDB Entry DOI: 10.7270/Q24T6MRQ
More data for this
Ligand-Target Pair
Protein G9a (G9a)


(Homo sapiens (Human))
BDBM413391
PNG
(US10407423, Compound 1-02)
Show SMILES COc1cc2c3[nH]c(CC4CCN(C)CC4)cc3c(nc2cc1OCCCN1CCCC1)-c1ccc(C)o1
Show InChI InChI=1S/C31H40N4O3/c1-21-7-8-27(38-21)31-25-18-23(17-22-9-14-34(2)15-10-22)32-30(25)24-19-28(36-3)29(20-26(24)33-31)37-16-6-13-35-11-4-5-12-35/h7-8,18-20,22,32H,4-6,9-17H2,1-3H3
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FUNDACIÓN PARA LA INVESTIGACIÓN MÉDICA APLICADA

US Patent


Assay Description
The biochemical assay to measure G9a enzyme activity relies on time-resolved fluorescence energy transfer (TR-FRET) between europium cryptate (donor)...


US Patent US10407423 (2019)


BindingDB Entry DOI: 10.7270/Q24T6MRQ
More data for this
Ligand-Target Pair
DNA (cytosine-5)-methyltransferase 1


(Homo sapiens (Human))
BDBM413391
PNG
(US10407423, Compound 1-02)
Show SMILES COc1cc2c3[nH]c(CC4CCN(C)CC4)cc3c(nc2cc1OCCCN1CCCC1)-c1ccc(C)o1
Show InChI InChI=1S/C31H40N4O3/c1-21-7-8-27(38-21)31-25-18-23(17-22-9-14-34(2)15-10-22)32-30(25)24-19-28(36-3)29(20-26(24)33-31)37-16-6-13-35-11-4-5-12-35/h7-8,18-20,22,32H,4-6,9-17H2,1-3H3
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FUNDACIÓN PARA LA INVESTIGACIÓN MÉDICA APLICADA

US Patent


Assay Description
The biochemical assay to measure DNMT1 enzyme activity relies on time-resolved fluorescence energy transfer (TR-FRET) between lumi4-Tb (donor) and d2...


US Patent US10407423 (2019)


BindingDB Entry DOI: 10.7270/Q24T6MRQ
More data for this
Ligand-Target Pair
Protein G9a (G9a)


(Homo sapiens (Human))
BDBM413408
PNG
(US10407423, Compound 3-02)
Show SMILES COc1cc2c(cc1OCCCN1CCCC1)nc(-c1ccc(C)o1)c1ccc(CC3CCNCC3)nc21
Show InChI InChI=1S/C31H38N4O3/c1-21-6-9-27(38-21)31-24-8-7-23(18-22-10-12-32-13-11-22)33-30(24)25-19-28(36-2)29(20-26(25)34-31)37-17-5-16-35-14-3-4-15-35/h6-9,19-20,22,32H,3-5,10-18H2,1-2H3
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FUNDACIÓN PARA LA INVESTIGACIÓN MÉDICA APLICADA

US Patent


Assay Description
The biochemical assay to measure G9a enzyme activity relies on time-resolved fluorescence energy transfer (TR-FRET) between europium cryptate (donor)...


US Patent US10407423 (2019)


BindingDB Entry DOI: 10.7270/Q24T6MRQ
More data for this
Ligand-Target Pair
Protein G9a (G9a)


(Homo sapiens (Human))
BDBM413393
PNG
(US10407423, Compound 1-05)
Show SMILES CCc1ccc(o1)-c1cc(Cl)c2cc(OC)c(OCCCN3CCCC3)cc2n1
Show InChI InChI=1S/C23H27ClN2O3/c1-3-16-7-8-21(29-16)20-14-18(24)17-13-22(27-2)23(15-19(17)25-20)28-12-6-11-26-9-4-5-10-26/h7-8,13-15H,3-6,9-12H2,1-2H3
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FUNDACIÓN PARA LA INVESTIGACIÓN MÉDICA APLICADA

US Patent


Assay Description
The biochemical assay to measure G9a enzyme activity relies on time-resolved fluorescence energy transfer (TR-FRET) between europium cryptate (donor)...


US Patent US10407423 (2019)


BindingDB Entry DOI: 10.7270/Q24T6MRQ
More data for this
Ligand-Target Pair
DNA (cytosine-5)-methyltransferase 1


(Homo sapiens (Human))
BDBM413399
PNG
(US10407423, Compound 2-06)
Show SMILES COc1cc2c3NC(CC4CCN(C)CC4)CCc3c(nc2cc1OCCCN1CCCC1)-c1ccc(C)o1
Show InChI InChI=1S/C32H44N4O3/c1-22-7-10-28(39-22)32-25-9-8-24(19-23-11-16-35(2)17-12-23)33-31(25)26-20-29(37-3)30(21-27(26)34-32)38-18-6-15-36-13-4-5-14-36/h7,10,20-21,23-24,33H,4-6,8-9,11-19H2,1-3H3
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FUNDACIÓN PARA LA INVESTIGACIÓN MÉDICA APLICADA

US Patent


Assay Description
The biochemical assay to measure DNMT1 enzyme activity relies on time-resolved fluorescence energy transfer (TR-FRET) between lumi4-Tb (donor) and d2...


US Patent US10407423 (2019)


BindingDB Entry DOI: 10.7270/Q24T6MRQ
More data for this
Ligand-Target Pair
Protein G9a (G9a)


(Homo sapiens (Human))
BDBM413392
PNG
(US10407423, Compound 1-03)
Show SMILES COc1cc2c3[nH]c(CC4CCN(CC4)C(C)C)cc3c(nc2cc1OCCCN1CCCC1)-c1ccc(C)o1
Show InChI InChI=1S/C33H44N4O3/c1-22(2)37-15-10-24(11-16-37)18-25-19-27-32(34-25)26-20-30(38-4)31(39-17-7-14-36-12-5-6-13-36)21-28(26)35-33(27)29-9-8-23(3)40-29/h8-9,19-22,24,34H,5-7,10-18H2,1-4H3
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FUNDACIÓN PARA LA INVESTIGACIÓN MÉDICA APLICADA

US Patent


Assay Description
The biochemical assay to measure G9a enzyme activity relies on time-resolved fluorescence energy transfer (TR-FRET) between europium cryptate (donor)...


US Patent US10407423 (2019)


BindingDB Entry DOI: 10.7270/Q24T6MRQ
More data for this
Ligand-Target Pair
DNA (cytosine-5)-methyltransferase 1


(Homo sapiens (Human))
BDBM413405
PNG
(US10407423, Compound 2-12)
Show SMILES COc1cc2c3NC(CC4CCN(CC4)C4CCCCC4)CCc3c(nc2cc1OCCCN1CCCC1)-c1ccc(C)o1
Show InChI InChI=1S/C37H52N4O3/c1-26-11-14-33(44-26)37-30-13-12-28(23-27-15-20-41(21-16-27)29-9-4-3-5-10-29)38-36(30)31-24-34(42-2)35(25-32(31)39-37)43-22-8-19-40-17-6-7-18-40/h11,14,24-25,27-29,38H,3-10,12-13,15-23H2,1-2H3
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FUNDACIÓN PARA LA INVESTIGACIÓN MÉDICA APLICADA

US Patent


Assay Description
The biochemical assay to measure DNMT1 enzyme activity relies on time-resolved fluorescence energy transfer (TR-FRET) between lumi4-Tb (donor) and d2...


US Patent US10407423 (2019)


BindingDB Entry DOI: 10.7270/Q24T6MRQ
More data for this
Ligand-Target Pair
DNA (cytosine-5)-methyltransferase 1


(Homo sapiens (Human))
BDBM413402
PNG
(US10407423, Compound 2-09)
Show SMILES COc1cc2c3N[C@@H](CC4CCN(C)CC4)CCc3c(nc2cc1OCCCN1CCCC1)-c1ccc(C)o1
Show InChI InChI=1S/C32H44N4O3/c1-22-7-10-28(39-22)32-25-9-8-24(19-23-11-16-35(2)17-12-23)33-31(25)26-20-29(37-3)30(21-27(26)34-32)38-18-6-15-36-13-4-5-14-36/h7,10,20-21,23-24,33H,4-6,8-9,11-19H2,1-3H3/t24-/m1/s1
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n/an/a 750n/an/an/an/an/an/a



FUNDACIÓN PARA LA INVESTIGACIÓN MÉDICA APLICADA

US Patent


Assay Description
The biochemical assay to measure DNMT1 enzyme activity relies on time-resolved fluorescence energy transfer (TR-FRET) between lumi4-Tb (donor) and d2...


US Patent US10407423 (2019)


BindingDB Entry DOI: 10.7270/Q24T6MRQ
More data for this
Ligand-Target Pair
DNA (cytosine-5)-methyltransferase 1


(Homo sapiens (Human))
BDBM413395
PNG
(US10407423, Compound 2-02)
Show SMILES Cc1ccc(o1)-c1nc2cc(OCCCN3CCCC3)ccc2c2NCCCc12
Show InChI InChI=1S/C24H29N3O2/c1-17-7-10-22(29-17)24-20-6-4-11-25-23(20)19-9-8-18(16-21(19)26-24)28-15-5-14-27-12-2-3-13-27/h7-10,16,25H,2-6,11-15H2,1H3
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n/an/a 750n/an/an/an/an/an/a



FUNDACIÓN PARA LA INVESTIGACIÓN MÉDICA APLICADA

US Patent


Assay Description
The biochemical assay to measure DNMT1 enzyme activity relies on time-resolved fluorescence energy transfer (TR-FRET) between lumi4-Tb (donor) and d2...


US Patent US10407423 (2019)


BindingDB Entry DOI: 10.7270/Q24T6MRQ
More data for this
Ligand-Target Pair
DNA (cytosine-5)-methyltransferase 1


(Homo sapiens (Human))
BDBM413403
PNG
(US10407423, Compound 2-10)
Show SMILES COc1cc2c3N[C@H](CC4CCN(C)CC4)CCc3c(nc2cc1OCCCN1CCCC1)-c1ccc(C)o1
Show InChI InChI=1S/C32H44N4O3/c1-22-7-10-28(39-22)32-25-9-8-24(19-23-11-16-35(2)17-12-23)33-31(25)26-20-29(37-3)30(21-27(26)34-32)38-18-6-15-36-13-4-5-14-36/h7,10,20-21,23-24,33H,4-6,8-9,11-19H2,1-3H3/t24-/m0/s1
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n/an/a 750n/an/an/an/an/an/a



FUNDACIÓN PARA LA INVESTIGACIÓN MÉDICA APLICADA

US Patent


Assay Description
The biochemical assay to measure DNMT1 enzyme activity relies on time-resolved fluorescence energy transfer (TR-FRET) between lumi4-Tb (donor) and d2...


US Patent US10407423 (2019)


BindingDB Entry DOI: 10.7270/Q24T6MRQ
More data for this
Ligand-Target Pair
DNA (cytosine-5)-methyltransferase 1


(Homo sapiens (Human))
BDBM413397
PNG
(US10407423, Compound 2-04)
Show SMILES COc1cc2c3N(CCCN4CCCC4)CCCc3c(nc2cc1OCCCN1CCCC1)-c1ccc(C)o1
Show InChI InChI=1S/C32H44N4O3/c1-24-11-12-28(39-24)31-25-10-7-19-36(20-8-17-34-13-3-4-14-34)32(25)26-22-29(37-2)30(23-27(26)33-31)38-21-9-18-35-15-5-6-16-35/h11-12,22-23H,3-10,13-21H2,1-2H3
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n/an/a 750n/an/an/an/an/an/a



FUNDACIÓN PARA LA INVESTIGACIÓN MÉDICA APLICADA

US Patent


Assay Description
The biochemical assay to measure DNMT1 enzyme activity relies on time-resolved fluorescence energy transfer (TR-FRET) between lumi4-Tb (donor) and d2...


US Patent US10407423 (2019)


BindingDB Entry DOI: 10.7270/Q24T6MRQ
More data for this
Ligand-Target Pair
DNA (cytosine-5)-methyltransferase 1


(Homo sapiens (Human))
BDBM413398
PNG
(US10407423, Compound 2-05)
Show SMILES COc1cc2c3NC(CC4CCNCC4)CCc3c(nc2cc1OCCCN1CCCC1)-c1ccc(C)o1
Show InChI InChI=1S/C31H42N4O3/c1-21-6-9-27(38-21)31-24-8-7-23(18-22-10-12-32-13-11-22)33-30(24)25-19-28(36-2)29(20-26(25)34-31)37-17-5-16-35-14-3-4-15-35/h6,9,19-20,22-23,32-33H,3-5,7-8,10-18H2,1-2H3
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n/an/a 750n/an/an/an/an/an/a



FUNDACIÓN PARA LA INVESTIGACIÓN MÉDICA APLICADA

US Patent


Assay Description
The biochemical assay to measure DNMT1 enzyme activity relies on time-resolved fluorescence energy transfer (TR-FRET) between lumi4-Tb (donor) and d2...


US Patent US10407423 (2019)


BindingDB Entry DOI: 10.7270/Q24T6MRQ
More data for this
Ligand-Target Pair
DNA (cytosine-5)-methyltransferase 1


(Homo sapiens (Human))
BDBM413392
PNG
(US10407423, Compound 1-03)
Show SMILES COc1cc2c3[nH]c(CC4CCN(CC4)C(C)C)cc3c(nc2cc1OCCCN1CCCC1)-c1ccc(C)o1
Show InChI InChI=1S/C33H44N4O3/c1-22(2)37-15-10-24(11-16-37)18-25-19-27-32(34-25)26-20-30(38-4)31(39-17-7-14-36-12-5-6-13-36)21-28(26)35-33(27)29-9-8-23(3)40-29/h8-9,19-22,24,34H,5-7,10-18H2,1-4H3
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n/an/a 750n/an/an/an/an/an/a



FUNDACIÓN PARA LA INVESTIGACIÓN MÉDICA APLICADA

US Patent


Assay Description
The biochemical assay to measure DNMT1 enzyme activity relies on time-resolved fluorescence energy transfer (TR-FRET) between lumi4-Tb (donor) and d2...


US Patent US10407423 (2019)


BindingDB Entry DOI: 10.7270/Q24T6MRQ
More data for this
Ligand-Target Pair
DNA (cytosine-5)-methyltransferase 1


(Homo sapiens (Human))
BDBM413400
PNG
(US10407423, Compound 2-07)
Show SMILES COc1cc2c3NC(CC4CCN(CC4)C4CC4)CCc3c(nc2cc1OCCCN1CCCC1)-c1ccc(C)o1
Show InChI InChI=1S/C34H46N4O3/c1-23-6-11-30(41-23)34-27-10-7-25(20-24-12-17-38(18-13-24)26-8-9-26)35-33(27)28-21-31(39-2)32(22-29(28)36-34)40-19-5-16-37-14-3-4-15-37/h6,11,21-22,24-26,35H,3-5,7-10,12-20H2,1-2H3
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n/an/a 750n/an/an/an/an/an/a



FUNDACIÓN PARA LA INVESTIGACIÓN MÉDICA APLICADA

US Patent


Assay Description
The biochemical assay to measure DNMT1 enzyme activity relies on time-resolved fluorescence energy transfer (TR-FRET) between lumi4-Tb (donor) and d2...


US Patent US10407423 (2019)


BindingDB Entry DOI: 10.7270/Q24T6MRQ
More data for this
Ligand-Target Pair
DNA (cytosine-5)-methyltransferase 1


(Homo sapiens (Human))
BDBM413401
PNG
(US10407423, Compound 2-08)
Show SMILES COc1cc2c3NC(CC4CCN(CC4)C(C)C)CCc3c(nc2cc1OCCCN1CCCC1)-c1ccc(C)o1
Show InChI InChI=1S/C34H48N4O3/c1-23(2)38-17-12-25(13-18-38)20-26-9-10-27-33(35-26)28-21-31(39-4)32(40-19-7-16-37-14-5-6-15-37)22-29(28)36-34(27)30-11-8-24(3)41-30/h8,11,21-23,25-26,35H,5-7,9-10,12-20H2,1-4H3
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n/an/a 750n/an/an/an/an/an/a



FUNDACIÓN PARA LA INVESTIGACIÓN MÉDICA APLICADA

US Patent


Assay Description
The biochemical assay to measure DNMT1 enzyme activity relies on time-resolved fluorescence energy transfer (TR-FRET) between lumi4-Tb (donor) and d2...


US Patent US10407423 (2019)


BindingDB Entry DOI: 10.7270/Q24T6MRQ
More data for this
Ligand-Target Pair
DNA (cytosine-5)-methyltransferase 1


(Homo sapiens (Human))
BDBM413408
PNG
(US10407423, Compound 3-02)
Show SMILES COc1cc2c(cc1OCCCN1CCCC1)nc(-c1ccc(C)o1)c1ccc(CC3CCNCC3)nc21
Show InChI InChI=1S/C31H38N4O3/c1-21-6-9-27(38-21)31-24-8-7-23(18-22-10-12-32-13-11-22)33-30(24)25-19-28(36-2)29(20-26(25)34-31)37-17-5-16-35-14-3-4-15-35/h6-9,19-20,22,32H,3-5,10-18H2,1-2H3
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n/an/a 750n/an/an/an/an/an/a



FUNDACIÓN PARA LA INVESTIGACIÓN MÉDICA APLICADA

US Patent


Assay Description
The biochemical assay to measure DNMT1 enzyme activity relies on time-resolved fluorescence energy transfer (TR-FRET) between lumi4-Tb (donor) and d2...


US Patent US10407423 (2019)


BindingDB Entry DOI: 10.7270/Q24T6MRQ
More data for this
Ligand-Target Pair
DNA (cytosine-5)-methyltransferase 1


(Homo sapiens (Human))
BDBM413393
PNG
(US10407423, Compound 1-05)
Show SMILES CCc1ccc(o1)-c1cc(Cl)c2cc(OC)c(OCCCN3CCCC3)cc2n1
Show InChI InChI=1S/C23H27ClN2O3/c1-3-16-7-8-21(29-16)20-14-18(24)17-13-22(27-2)23(15-19(17)25-20)28-12-6-11-26-9-4-5-10-26/h7-8,13-15H,3-6,9-12H2,1-2H3
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n/an/a 750n/an/an/an/an/an/a



FUNDACIÓN PARA LA INVESTIGACIÓN MÉDICA APLICADA

US Patent


Assay Description
The biochemical assay to measure DNMT1 enzyme activity relies on time-resolved fluorescence energy transfer (TR-FRET) between lumi4-Tb (donor) and d2...


US Patent US10407423 (2019)


BindingDB Entry DOI: 10.7270/Q24T6MRQ
More data for this
Ligand-Target Pair
DNA (cytosine-5)-methyltransferase 1


(Homo sapiens (Human))
BDBM413409
PNG
(US10407423, Compound 3-03)
Show SMILES COc1cc2c(cc1OCCCN1CCCC1)nc(-c1ccc(C)o1)c1ccc(CC3CCN(C)CC3)nc21
Show InChI InChI=1S/C32H40N4O3/c1-22-7-10-28(39-22)32-25-9-8-24(19-23-11-16-35(2)17-12-23)33-31(25)26-20-29(37-3)30(21-27(26)34-32)38-18-6-15-36-13-4-5-14-36/h7-10,20-21,23H,4-6,11-19H2,1-3H3
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n/an/a 5.50E+3n/an/an/an/an/an/a



FUNDACIÓN PARA LA INVESTIGACIÓN MÉDICA APLICADA

US Patent


Assay Description
The biochemical assay to measure DNMT1 enzyme activity relies on time-resolved fluorescence energy transfer (TR-FRET) between lumi4-Tb (donor) and d2...


US Patent US10407423 (2019)


BindingDB Entry DOI: 10.7270/Q24T6MRQ
More data for this
Ligand-Target Pair
DNA (cytosine-5)-methyltransferase 1


(Homo sapiens (Human))
BDBM413406
PNG
(US10407423, Compound 2-13)
Show SMILES COc1cc2c3NC(CC4CCN(C)CC4)CCc3c(nc2cc1OCCCN1CCCC1)-c1cc(C)oc1C
Show InChI InChI=1S/C33H46N4O3/c1-22-18-27(23(2)40-22)32-26-9-8-25(19-24-10-15-36(3)16-11-24)34-33(26)28-20-30(38-4)31(21-29(28)35-32)39-17-7-14-37-12-5-6-13-37/h18,20-21,24-25,34H,5-17,19H2,1-4H3
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FUNDACIÓN PARA LA INVESTIGACIÓN MÉDICA APLICADA

US Patent


Assay Description
The biochemical assay to measure DNMT1 enzyme activity relies on time-resolved fluorescence energy transfer (TR-FRET) between lumi4-Tb (donor) and d2...


US Patent US10407423 (2019)


BindingDB Entry DOI: 10.7270/Q24T6MRQ
More data for this
Ligand-Target Pair
Protein G9a (G9a)


(Homo sapiens (Human))
BDBM413407
PNG
(US10407423, Compound 3-01)
Show SMILES COc1cc2c(cc1OCCCN1CCCC1)nc(-c1ccc(C)o1)c1cccnc21
Show InChI InChI=1S/C25H27N3O3/c1-17-8-9-21(31-17)25-18-7-5-10-26-24(18)19-15-22(29-2)23(16-20(19)27-25)30-14-6-13-28-11-3-4-12-28/h5,7-10,15-16H,3-4,6,11-14H2,1-2H3
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n/an/a 5.50E+3n/an/an/an/an/an/a



FUNDACIÓN PARA LA INVESTIGACIÓN MÉDICA APLICADA

US Patent


Assay Description
The biochemical assay to measure G9a enzyme activity relies on time-resolved fluorescence energy transfer (TR-FRET) between europium cryptate (donor)...


US Patent US10407423 (2019)


BindingDB Entry DOI: 10.7270/Q24T6MRQ
More data for this
Ligand-Target Pair
DNA (cytosine-5)-methyltransferase 1


(Homo sapiens (Human))
BDBM413412
PNG
(US10407423, Compound 4-04)
Show SMILES COc1cc2c3[nH]n(CC4CCN(C)CC4)c(=O)c3c(nc2cc1OCCCN1CCCC1)-c1ccc(C)o1
Show InChI InChI=1S/C30H39N5O4/c1-20-7-8-24(39-20)29-27-28(32-35(30(27)36)19-21-9-14-33(2)15-10-21)22-17-25(37-3)26(18-23(22)31-29)38-16-6-13-34-11-4-5-12-34/h7-8,17-18,21,32H,4-6,9-16,19H2,1-3H3
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n/an/a 5.50E+3n/an/an/an/an/an/a



FUNDACIÓN PARA LA INVESTIGACIÓN MÉDICA APLICADA

US Patent


Assay Description
The biochemical assay to measure DNMT1 enzyme activity relies on time-resolved fluorescence energy transfer (TR-FRET) between lumi4-Tb (donor) and d2...


US Patent US10407423 (2019)


BindingDB Entry DOI: 10.7270/Q24T6MRQ
More data for this
Ligand-Target Pair
DNA (cytosine-5)-methyltransferase 1


(Homo sapiens (Human))
BDBM413394
PNG
(US10407423, Compound 2-01)
Show SMILES COc1ccc2c3NCCCc3c(nc2c1)-c1ccc(C)o1
Show InChI InChI=1S/C18H18N2O2/c1-11-5-8-16(22-11)18-14-4-3-9-19-17(14)13-7-6-12(21-2)10-15(13)20-18/h5-8,10,19H,3-4,9H2,1-2H3
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n/an/a 5.50E+3n/an/an/an/an/an/a



FUNDACIÓN PARA LA INVESTIGACIÓN MÉDICA APLICADA

US Patent


Assay Description
The biochemical assay to measure DNMT1 enzyme activity relies on time-resolved fluorescence energy transfer (TR-FRET) between lumi4-Tb (donor) and d2...


US Patent US10407423 (2019)


BindingDB Entry DOI: 10.7270/Q24T6MRQ
More data for this
Ligand-Target Pair
DNA (cytosine-5)-methyltransferase 1


(Homo sapiens (Human))
BDBM413411
PNG
(US10407423, Compound 4-03)
Show SMILES COc1cc2c3[nH]n(C4CCN(C)CC4)c(=O)c3c(nc2cc1OCCCN1CCCC1)-c1ccc(C)o1
Show InChI InChI=1S/C29H37N5O4/c1-19-7-8-23(38-19)28-26-27(31-34(29(26)35)20-9-14-32(2)15-10-20)21-17-24(36-3)25(18-22(21)30-28)37-16-6-13-33-11-4-5-12-33/h7-8,17-18,20,31H,4-6,9-16H2,1-3H3
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FUNDACIÓN PARA LA INVESTIGACIÓN MÉDICA APLICADA

US Patent


Assay Description
The biochemical assay to measure DNMT1 enzyme activity relies on time-resolved fluorescence energy transfer (TR-FRET) between lumi4-Tb (donor) and d2...


US Patent US10407423 (2019)


BindingDB Entry DOI: 10.7270/Q24T6MRQ
More data for this
Ligand-Target Pair
DNA (cytosine-5)-methyltransferase 1


(Homo sapiens (Human))
BDBM413413
PNG
(US10407423, Compound 4-05)
Show SMILES COc1cc2c3n(CC4CCN(C)CC4)n(CC4CCN(C)CC4)c(=O)c3c(nc2cc1OCCCN1CCCC1)-c1ccc(C)o1
Show InChI InChI=1S/C37H52N6O4/c1-26-8-9-31(47-26)35-34-36(29-22-32(45-4)33(23-30(29)38-35)46-21-7-16-41-14-5-6-15-41)42(24-27-10-17-39(2)18-11-27)43(37(34)44)25-28-12-19-40(3)20-13-28/h8-9,22-23,27-28H,5-7,10-21,24-25H2,1-4H3
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n/an/a 5.50E+3n/an/an/an/an/an/a



FUNDACIÓN PARA LA INVESTIGACIÓN MÉDICA APLICADA

US Patent


Assay Description
The biochemical assay to measure DNMT1 enzyme activity relies on time-resolved fluorescence energy transfer (TR-FRET) between lumi4-Tb (donor) and d2...


US Patent US10407423 (2019)


BindingDB Entry DOI: 10.7270/Q24T6MRQ
More data for this
Ligand-Target Pair
DNA (cytosine-5)-methyltransferase 1


(Homo sapiens (Human))
BDBM413404
PNG
(US10407423, Compound 2-11)
Show SMILES COc1cc2c3NC(CC4CCN(CC4)C(C)=O)CCc3c(nc2cc1OCCCN1CCCC1)-c1ccc(C)o1
Show InChI InChI=1S/C33H44N4O4/c1-22-7-10-29(41-22)33-26-9-8-25(19-24-11-16-37(17-12-24)23(2)38)34-32(26)27-20-30(39-3)31(21-28(27)35-33)40-18-6-15-36-13-4-5-14-36/h7,10,20-21,24-25,34H,4-6,8-9,11-19H2,1-3H3
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n/an/a 5.50E+3n/an/an/an/an/an/a



FUNDACIÓN PARA LA INVESTIGACIÓN MÉDICA APLICADA

US Patent


Assay Description
The biochemical assay to measure DNMT1 enzyme activity relies on time-resolved fluorescence energy transfer (TR-FRET) between lumi4-Tb (donor) and d2...


US Patent US10407423 (2019)


BindingDB Entry DOI: 10.7270/Q24T6MRQ
More data for this
Ligand-Target Pair
DNA (cytosine-5)-methyltransferase 1


(Homo sapiens (Human))
BDBM413396
PNG
(US10407423, Compound 2-03)
Show SMILES COc1cc2c3NCCCc3c(nc2cc1OCCCN1CCCC1)-c1ccc(C)o1
Show InChI InChI=1S/C25H31N3O3/c1-17-8-9-21(31-17)25-18-7-5-10-26-24(18)19-15-22(29-2)23(16-20(19)27-25)30-14-6-13-28-11-3-4-12-28/h8-9,15-16,26H,3-7,10-14H2,1-2H3
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n/an/a 5.50E+3n/an/an/an/an/an/a



FUNDACIÓN PARA LA INVESTIGACIÓN MÉDICA APLICADA

US Patent


Assay Description
The biochemical assay to measure DNMT1 enzyme activity relies on time-resolved fluorescence energy transfer (TR-FRET) between lumi4-Tb (donor) and d2...


US Patent US10407423 (2019)


BindingDB Entry DOI: 10.7270/Q24T6MRQ
More data for this
Ligand-Target Pair
DNA (cytosine-5)-methyltransferase 1


(Homo sapiens (Human))
BDBM413407
PNG
(US10407423, Compound 3-01)
Show SMILES COc1cc2c(cc1OCCCN1CCCC1)nc(-c1ccc(C)o1)c1cccnc21
Show InChI InChI=1S/C25H27N3O3/c1-17-8-9-21(31-17)25-18-7-5-10-26-24(18)19-15-22(29-2)23(16-20(19)27-25)30-14-6-13-28-11-3-4-12-28/h5,7-10,15-16H,3-4,6,11-14H2,1-2H3
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antibodypedia
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n/an/a 5.50E+3n/an/an/an/an/an/a



FUNDACIÓN PARA LA INVESTIGACIÓN MÉDICA APLICADA

US Patent


Assay Description
The biochemical assay to measure DNMT1 enzyme activity relies on time-resolved fluorescence energy transfer (TR-FRET) between lumi4-Tb (donor) and d2...


US Patent US10407423 (2019)


BindingDB Entry DOI: 10.7270/Q24T6MRQ
More data for this
Ligand-Target Pair
Protein G9a (G9a)


(Homo sapiens (Human))
BDBM413395
PNG
(US10407423, Compound 2-02)
Show SMILES Cc1ccc(o1)-c1nc2cc(OCCCN3CCCC3)ccc2c2NCCCc12
Show InChI InChI=1S/C24H29N3O2/c1-17-7-10-22(29-17)24-20-6-4-11-25-23(20)19-9-8-18(16-21(19)26-24)28-15-5-14-27-12-2-3-13-27/h7-10,16,25H,2-6,11-15H2,1H3
PDB

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n/an/a 5.50E+3n/an/an/an/an/an/a



FUNDACIÓN PARA LA INVESTIGACIÓN MÉDICA APLICADA

US Patent


Assay Description
The biochemical assay to measure G9a enzyme activity relies on time-resolved fluorescence energy transfer (TR-FRET) between europium cryptate (donor)...


US Patent US10407423 (2019)


BindingDB Entry DOI: 10.7270/Q24T6MRQ
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%