Compile Data Set for Download or QSAR
maximum 50k data
Found 34 Enz. Inhib. hit(s) with all data for entry = 8690
TargetToll-like receptor 7(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM413414( methyl 4-((2-amino-4-(pentylamino)-5H-pyrrolo[3,2...)
Affinity DataEC50:  10nMAssay Description:Human embryonic kidney 293 (HEK 293) cells were stably transfected with human TLR7 and an NF-kB-driven luciferase reporter vector (pNifty-Luciferase)...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetToll-like receptor 7(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM413447(5-(5-amino-2-methoxybenzyl)-N4-pentyl-5H-pyrrolo[3...)
Affinity DataEC50:  1nMAssay Description:Human embryonic kidney 293 (HEK 293) cells were stably transfected with human TLR7 and an NF-kB-driven luciferase reporter vector (pNifty-Luciferase)...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetToll-like receptor 7(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM413416(2-(2-(dimethylamino)ethoxy)ethyl 4-((2-amino-4-(pe...)
Affinity DataEC50:  20nMAssay Description:Human embryonic kidney 293 (HEK 293) cells were stably transfected with human TLR7 and an NF-kB-driven luciferase reporter vector (pNifty-Luciferase)...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetToll-like receptor 7(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM413417(US10407431, Example 4 | methyl 3-((2-amino-4-(pent...)
Affinity DataEC50: <5nMAssay Description:Human embryonic kidney 293 (HEK 293) cells were stably transfected with human TLR7 and an NF-kB-driven luciferase reporter vector (pNifty-Luciferase)...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetToll-like receptor 7(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM413418(US10407431, Example 5 | methyl 2-(3-((2-amino-4-(p...)
Affinity DataEC50:  10nMAssay Description:Human embryonic kidney 293 (HEK 293) cells were stably transfected with human TLR7 and an NF-kB-driven luciferase reporter vector (pNifty-Luciferase)...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetToll-like receptor 7(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM413419(US10407431, Example 6 | ethyl 3-(3-((2-amino-4-(pe...)
Affinity DataEC50:  30nMAssay Description:Human embryonic kidney 293 (HEK 293) cells were stably transfected with human TLR7 and an NF-kB-driven luciferase reporter vector (pNifty-Luciferase)...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetToll-like receptor 7(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM413420(US10407431, Example 7 | methyl 2-(3-((2-amino-4-(p...)
Affinity DataEC50:  100nMAssay Description:Human embryonic kidney 293 (HEK 293) cells were stably transfected with human TLR7 and an NF-kB-driven luciferase reporter vector (pNifty-Luciferase)...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetToll-like receptor 7(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM413421(2-morpholino-2-oxoethyl 2-(3-((2-amino-4-(pentylam...)
Affinity DataEC50:  40nMAssay Description:Human embryonic kidney 293 (HEK 293) cells were stably transfected with human TLR7 and an NF-kB-driven luciferase reporter vector (pNifty-Luciferase)...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetToll-like receptor 7(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM413422(2-morpholino-2-oxoethyl 2-(3-((2-amino-4-(pentylam...)
Affinity DataEC50:  10nMAssay Description:Human embryonic kidney 293 (HEK 293) cells were stably transfected with human TLR7 and an NF-kB-driven luciferase reporter vector (pNifty-Luciferase)...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetToll-like receptor 7(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM413423(2-morpholino-2-oxoethyl 2-(4-((2-amino-4-(pentylam...)
Affinity DataEC50:  6nMAssay Description:Human embryonic kidney 293 (HEK 293) cells were stably transfected with human TLR7 and an NF-kB-driven luciferase reporter vector (pNifty-Luciferase)...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetToll-like receptor 7(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM413424(2-(morpholin-4-yl)-2-oxoethyl 3-(4-{[2-amino-4-(pe...)
Affinity DataEC50:  20nMAssay Description:Human embryonic kidney 293 (HEK 293) cells were stably transfected with human TLR7 and an NF-kB-driven luciferase reporter vector (pNifty-Luciferase)...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetToll-like receptor 7(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM413425((S)-2-morpholino-2-oxoethyl 3-(3-((2-amino-4-((1-h...)
Affinity DataEC50:  30nMAssay Description:Human embryonic kidney 293 (HEK 293) cells were stably transfected with human TLR7 and an NF-kB-driven luciferase reporter vector (pNifty-Luciferase)...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetToll-like receptor 7(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM413426((S)-2-morpholino-2-oxoethyl 2-(4-((2-amino-4-((1-h...)
Affinity DataEC50:  10nMAssay Description:Human embryonic kidney 293 (HEK 293) cells were stably transfected with human TLR7 and an NF-kB-driven luciferase reporter vector (pNifty-Luciferase)...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetToll-like receptor 7(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM413427((S)-2-morpholino-2-oxoethyl 2-(3-((2-amino-4-((1-h...)
Affinity DataEC50:  10nMAssay Description:Human embryonic kidney 293 (HEK 293) cells were stably transfected with human TLR7 and an NF-kB-driven luciferase reporter vector (pNifty-Luciferase)...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetToll-like receptor 7(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM413428((S)-2-morpholino-2-oxoethyl 3-(4-((2-amino-4-((1-h...)
Affinity DataEC50:  20nMAssay Description:Human embryonic kidney 293 (HEK 293) cells were stably transfected with human TLR7 and an NF-kB-driven luciferase reporter vector (pNifty-Luciferase)...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetToll-like receptor 7(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM413429(2-(morpholin-4-yl)-2-oxoethyl (2E)-3-(3-{[2-amino-...)
Affinity DataEC50: <5nMAssay Description:Human embryonic kidney 293 (HEK 293) cells were stably transfected with human TLR7 and an NF-kB-driven luciferase reporter vector (pNifty-Luciferase)...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetToll-like receptor 7(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM413430(2-(morpholin-4-yl)-2-oxoethyl 3-(3-{[2-amino-4-(pe...)
Affinity DataEC50:  50nMAssay Description:Human embryonic kidney 293 (HEK 293) cells were stably transfected with human TLR7 and an NF-kB-driven luciferase reporter vector (pNifty-Luciferase)...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetToll-like receptor 7(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM413431(2-(benzyloxy)-2-oxoethyl 2-(4-{[2-amino-4-(pentyla...)
Affinity DataEC50:  200nMAssay Description:Human embryonic kidney 293 (HEK 293) cells were stably transfected with human TLR7 and an NF-kB-driven luciferase reporter vector (pNifty-Luciferase)...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetToll-like receptor 7(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM413432(2-(dipropylcarbamoyl)methyl 2-(4-{[2-amino-4-(pent...)
Affinity DataEC50:  200nMAssay Description:Human embryonic kidney 293 (HEK 293) cells were stably transfected with human TLR7 and an NF-kB-driven luciferase reporter vector (pNifty-Luciferase)...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetToll-like receptor 7(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM413433(2-(dimethylamino)-2-oxoethyl 2-(4-((2-amino-4-(pen...)
Affinity DataEC50:  80nMAssay Description:Human embryonic kidney 293 (HEK 293) cells were stably transfected with human TLR7 and an NF-kB-driven luciferase reporter vector (pNifty-Luciferase)...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetToll-like receptor 7(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM413434(2-(4-methylpiperazin-1-yl)ethyl 2-(4-{[2-amino-4-(...)
Affinity DataEC50: <5nMAssay Description:Human embryonic kidney 293 (HEK 293) cells were stably transfected with human TLR7 and an NF-kB-driven luciferase reporter vector (pNifty-Luciferase)...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetToll-like receptor 7(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM413435(2-hydroxyethyl 2-(4-{[2-amino-4-(pentylamino)-5H-p...)
Affinity DataEC50: <6nMAssay Description:Human embryonic kidney 293 (HEK 293) cells were stably transfected with human TLR7 and an NF-kB-driven luciferase reporter vector (pNifty-Luciferase)...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetToll-like receptor 7(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM413436(4-(dimethylamino)butyl 2-(4-{[2-amino-4-(pentylami...)
Affinity DataEC50:  7nMAssay Description:Human embryonic kidney 293 (HEK 293) cells were stably transfected with human TLR7 and an NF-kB-driven luciferase reporter vector (pNifty-Luciferase)...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetToll-like receptor 7(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM413437(2-(morpholin-4-yl)ethyl 2-(4-{[2-amino-4-(pentylam...)
Affinity DataEC50:  8nMAssay Description:Human embryonic kidney 293 (HEK 293) cells were stably transfected with human TLR7 and an NF-kB-driven luciferase reporter vector (pNifty-Luciferase)...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetToll-like receptor 7(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM413438(2-(piperazin-1-yl)ethyl 2-(4-{[2-amino-4-(pentylam...)
Affinity DataEC50:  30nMAssay Description:Human embryonic kidney 293 (HEK 293) cells were stably transfected with human TLR7 and an NF-kB-driven luciferase reporter vector (pNifty-Luciferase)...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetToll-like receptor 7(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM413439(2-(dimethylamino)ethyl 2-(3-{[2-amino-4-(pentylami...)
Affinity DataEC50:  300nMAssay Description:Human embryonic kidney 293 (HEK 293) cells were stably transfected with human TLR7 and an NF-kB-driven luciferase reporter vector (pNifty-Luciferase)...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetToll-like receptor 7(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM413440(2-(piperazin-1-yl)ethyl 2-(3-{[2-amino-4-(pentylam...)
Affinity DataEC50:  500nMAssay Description:Human embryonic kidney 293 (HEK 293) cells were stably transfected with human TLR7 and an NF-kB-driven luciferase reporter vector (pNifty-Luciferase)...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetToll-like receptor 7(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM413441(2-(morpholin-4-yl)ethyl 2-(3-{[2-amino-4-(pentylam...)
Affinity DataEC50:  400nMAssay Description:Human embryonic kidney 293 (HEK 293) cells were stably transfected with human TLR7 and an NF-kB-driven luciferase reporter vector (pNifty-Luciferase)...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetToll-like receptor 7(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM413442(2-(4-methylpiperazin-1-yl)ethyl 2-(3-{[2-amino-4-(...)
Affinity DataEC50:  200nMAssay Description:Human embryonic kidney 293 (HEK 293) cells were stably transfected with human TLR7 and an NF-kB-driven luciferase reporter vector (pNifty-Luciferase)...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetToll-like receptor 7(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM413443(S)-2-((2-amino-5-(2-methoxy-5-(piperazin-1-ylmethy...)
Affinity DataEC50:  80nMAssay Description:Human embryonic kidney 293 (HEK 293) cells were stably transfected with human TLR7 and an NF-kB-driven luciferase reporter vector (pNifty-Luciferase)...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetToll-like receptor 7(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM413444(5-(2-methoxy-5-(piperazin-1-ylmethyl)benzyl)-N4-pe...)
Affinity DataEC50:  20nMAssay Description:Human embryonic kidney 293 (HEK 293) cells were stably transfected with human TLR7 and an NF-kB-driven luciferase reporter vector (pNifty-Luciferase)...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetToll-like receptor 7(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM413445(5-(2-methoxy-4-(piperazin-1-ylmethyl)benzyl)-N4-pe...)
Affinity DataEC50: <5nMAssay Description:Human embryonic kidney 293 (HEK 293) cells were stably transfected with human TLR7 and an NF-kB-driven luciferase reporter vector (pNifty-Luciferase)...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetToll-like receptor 7(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM413446((S)-2-((2-amino-5-(2-methoxy-4-(piperazin-1-ylmeth...)
Affinity DataEC50:  7nMAssay Description:Human embryonic kidney 293 (HEK 293) cells were stably transfected with human TLR7 and an NF-kB-driven luciferase reporter vector (pNifty-Luciferase)...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetToll-like receptor 7(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM413415(2-(dimethylamino)ethyl 4-((2-amino-4-(pentylamino)...)
Affinity DataEC50: <5nMAssay Description:Human embryonic kidney 293 (HEK 293) cells were stably transfected with human TLR7 and an NF-kB-driven luciferase reporter vector (pNifty-Luciferase)...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent