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Patent code US10407446

Compile Data Set for Download or QSAR
Found 78 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Dual specificity protein kinase TTK


(Homo sapiens (Human))
BDBM413460
PNG
(9-cyclohexyl-7-methyl-2-((7-methyl-[1,2,4]triazolo...)
Show SMILES Cc1cc2ncnn2cc1Nc1ncc2n(C)c(=O)n(C3CCCCC3)c2n1
Show InChI InChI=1S/C19H22N8O/c1-12-8-16-21-11-22-26(16)10-14(12)23-18-20-9-15-17(24-18)27(19(28)25(15)2)13-6-4-3-5-7-13/h8-11,13H,3-7H2,1-2H3,(H,20,23,24)
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n/an/a 501n/an/an/an/an/an/a



AstraZeneca AB

US Patent


Assay Description
The inhibitory activity of compounds against AURKA, AURKB, JAK1, JAK2 and JAK3 was determined in Z′-LYTEŽ assays run by ThermoFisher Scientific...


US Patent US10407446 (2019)


BindingDB Entry DOI: 10.7270/Q2MS3W4T
More data for this
Ligand-Target Pair
Dual specificity protein kinase TTK


(Homo sapiens (Human))
BDBM413457
PNG
(9-((1s,4s)-4-hydroxy-4-methylcyclohexyl)-7-methyl-...)
Show SMILES Cc1cc2ncnn2cc1Nc1ncc2n(C)c(=O)n([C@H]3CC[C@@](C)(O)CC3)c2n1
Show InChI InChI=1S/C20H24N8O2/c1-12-8-16-22-11-23-27(16)10-14(12)24-18-21-9-15-17(25-18)28(19(29)26(15)3)13-4-6-20(2,30)7-5-13/h8-11,13,30H,4-7H2,1-3H3,(H,21,24,25)/t13-,20+
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n/an/a 501n/an/an/an/an/an/a



AstraZeneca AB

US Patent


Assay Description
The inhibitory activity of compounds against AURKA, AURKB, JAK1, JAK2 and JAK3 was determined in Z′-LYTEŽ assays run by ThermoFisher Scientific...


US Patent US10407446 (2019)


BindingDB Entry DOI: 10.7270/Q2MS3W4T
More data for this
Ligand-Target Pair
Dual specificity protein kinase TTK


(Homo sapiens (Human))
BDBM413449
PNG
(9-((1s,4s)-4-hydroxycyclohexyl)-7-methyl-2-((7-met...)
Show SMILES Cc1cc2ncnn2cc1Nc1ncc2n(C)c(=O)n([C@@H]3CC[C@H](O)CC3)c2n1
Show InChI InChI=1S/C19H22N8O2/c1-11-7-16-21-10-22-26(16)9-14(11)23-18-20-8-15-17(24-18)27(19(29)25(15)2)12-3-5-13(28)6-4-12/h7-10,12-13,28H,3-6H2,1-2H3,(H,20,23,24)/t12-,13+
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n/an/a 794n/an/an/an/an/an/a



AstraZeneca AB

US Patent


Assay Description
The inhibitory activity of compounds against AURKA, AURKB, JAK1, JAK2 and JAK3 was determined in Z′-LYTEŽ assays run by ThermoFisher Scientific...


US Patent US10407446 (2019)


BindingDB Entry DOI: 10.7270/Q2MS3W4T
More data for this
Ligand-Target Pair
Dual specificity protein kinase TTK


(Homo sapiens (Human))
BDBM413453
PNG
(9-((1r,4r)-methoxycyclohexyl)-7-methyl-2-((7-methy...)
Show SMILES CO[C@H]1CC[C@@H](CC1)n1c2nc(Nc3cn4ncnc4cc3C)ncc2n(C)c1=O
Show InChI InChI=1S/C20H24N8O2/c1-12-8-17-22-11-23-27(17)10-15(12)24-19-21-9-16-18(25-19)28(20(29)26(16)2)13-4-6-14(30-3)7-5-13/h8-11,13-14H,4-7H2,1-3H3,(H,21,24,25)/t13-,14-
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n/an/a 1.26E+3n/an/an/an/an/an/a



AstraZeneca AB

US Patent


Assay Description
The inhibitory activity of compounds against AURKA, AURKB, JAK1, JAK2 and JAK3 was determined in Z′-LYTEŽ assays run by ThermoFisher Scientific...


US Patent US10407446 (2019)


BindingDB Entry DOI: 10.7270/Q2MS3W4T
More data for this
Ligand-Target Pair
Dual specificity protein kinase TTK


(Homo sapiens (Human))
BDBM413459
PNG
(9-((1s,4s)-4-hydroxy-1-methylcyclohexyl)-7-methyl-...)
Show SMILES Cc1cc2ncnn2cc1Nc1ncc2n(C)c(=O)n(c2n1)[C@]1(C)CC[C@H](O)CC1
Show InChI InChI=1S/C20H24N8O2/c1-12-8-16-22-11-23-27(16)10-14(12)24-18-21-9-15-17(25-18)28(19(30)26(15)3)20(2)6-4-13(29)5-7-20/h8-11,13,29H,4-7H2,1-3H3,(H,21,24,25)/t13-,20+
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n/an/a 1.59E+3n/an/an/an/an/an/a



AstraZeneca AB

US Patent


Assay Description
The inhibitory activity of compounds against AURKA, AURKB, JAK1, JAK2 and JAK3 was determined in Z′-LYTEŽ assays run by ThermoFisher Scientific...


US Patent US10407446 (2019)


BindingDB Entry DOI: 10.7270/Q2MS3W4T
More data for this
Ligand-Target Pair
Dual specificity protein kinase TTK


(Homo sapiens (Human))
BDBM413448
PNG
(9-((1r,4r)-4-hydroxycyclohexyl)-7-methyl-2-((7-met...)
Show SMILES Cc1cc2ncnn2cc1Nc1ncc2n(C)c(=O)n([C@H]3CC[C@H](O)CC3)c2n1
Show InChI InChI=1S/C19H22N8O2/c1-11-7-16-21-10-22-26(16)9-14(11)23-18-20-8-15-17(24-18)27(19(29)25(15)2)12-3-5-13(28)6-4-12/h7-10,12-13,28H,3-6H2,1-2H3,(H,20,23,24)/t12-,13-
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n/an/a 3.16E+3n/an/an/an/an/an/a



AstraZeneca AB

US Patent


Assay Description
The inhibitory activity of compounds against AURKA, AURKB, JAK1, JAK2 and JAK3 was determined in Z′-LYTEŽ assays run by ThermoFisher Scientific...


US Patent US10407446 (2019)


BindingDB Entry DOI: 10.7270/Q2MS3W4T
More data for this
Ligand-Target Pair
Dual specificity protein kinase TTK


(Homo sapiens (Human))
BDBM413456
PNG
(9-((1r,4r)-4-hydroxy-4-methylcyclohexyl)-7-methyl-...)
Show SMILES Cc1cc2ncnn2cc1Nc1ncc2n(C)c(=O)n([C@H]3CC[C@](C)(O)CC3)c2n1
Show InChI InChI=1S/C20H24N8O2/c1-12-8-16-22-11-23-27(16)10-14(12)24-18-21-9-15-17(25-18)28(19(29)26(15)3)13-4-6-20(2,30)7-5-13/h8-11,13,30H,4-7H2,1-3H3,(H,21,24,25)/t13-,20-
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n/an/a 3.98E+3n/an/an/an/an/an/a



AstraZeneca AB

US Patent


Assay Description
The inhibitory activity of compounds against AURKA, AURKB, JAK1, JAK2 and JAK3 was determined in Z′-LYTEŽ assays run by ThermoFisher Scientific...


US Patent US10407446 (2019)


BindingDB Entry DOI: 10.7270/Q2MS3W4T
More data for this
Ligand-Target Pair
Aurora kinase A/Targeting protein for Xklp2


(Homo sapiens (Human))
BDBM413460
PNG
(9-cyclohexyl-7-methyl-2-((7-methyl-[1,2,4]triazolo...)
Show SMILES Cc1cc2ncnn2cc1Nc1ncc2n(C)c(=O)n(C3CCCCC3)c2n1
Show InChI InChI=1S/C19H22N8O/c1-12-8-16-21-11-22-26(16)10-14(12)23-18-20-9-15-17(24-18)27(19(28)25(15)2)13-6-4-3-5-7-13/h8-11,13H,3-7H2,1-2H3,(H,20,23,24)
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n/an/a 3.98E+3n/an/an/an/an/an/a



AstraZeneca AB

US Patent


Assay Description
The inhibitory activity of compounds against AURKA, AURKB, JAK1, JAK2 and JAK3 was determined in Z′-LYTEŽ assays run by ThermoFisher Scientific...


US Patent US10407446 (2019)


BindingDB Entry DOI: 10.7270/Q2MS3W4T
More data for this
Ligand-Target Pair
Dual specificity protein kinase TTK


(Homo sapiens (Human))
BDBM413450
PNG
(7-methyl-2-((7-methyl-[1,2,4]triazolo[1,5-a]pyridi...)
Show SMILES Cc1cc2ncnn2cc1Nc1ncc2n(C)c(=O)n(C3CCOCC3)c2n1
Show InChI InChI=1S/C18H20N8O2/c1-11-7-15-20-10-21-25(15)9-13(11)22-17-19-8-14-16(23-17)26(18(27)24(14)2)12-3-5-28-6-4-12/h7-10,12H,3-6H2,1-2H3,(H,19,22,23)
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n/an/a 5.01E+3n/an/an/an/an/an/a



AstraZeneca AB

US Patent


Assay Description
The inhibitory activity of compounds against AURKA, AURKB, JAK1, JAK2 and JAK3 was determined in Z′-LYTEŽ assays run by ThermoFisher Scientific...


US Patent US10407446 (2019)


BindingDB Entry DOI: 10.7270/Q2MS3W4T
More data for this
Ligand-Target Pair
Dual specificity protein kinase TTK


(Homo sapiens (Human))
BDBM413452
PNG
(9-((1s,4s)-4-methoxycyclohexyl)-7-methyl-2-((7-met...)
Show SMILES CO[C@H]1CC[C@H](CC1)n1c2nc(Nc3cn4ncnc4cc3C)ncc2n(C)c1=O
Show InChI InChI=1S/C20H24N8O2/c1-12-8-17-22-11-23-27(17)10-15(12)24-19-21-9-16-18(25-19)28(20(29)26(16)2)13-4-6-14(30-3)7-5-13/h8-11,13-14H,4-7H2,1-3H3,(H,21,24,25)/t13-,14+
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n/an/a 5.01E+3n/an/an/an/an/an/a



AstraZeneca AB

US Patent


Assay Description
The inhibitory activity of compounds against AURKA, AURKB, JAK1, JAK2 and JAK3 was determined in Z′-LYTEŽ assays run by ThermoFisher Scientific...


US Patent US10407446 (2019)


BindingDB Entry DOI: 10.7270/Q2MS3W4T
More data for this
Ligand-Target Pair
Dual specificity protein kinase TTK


(Homo sapiens (Human))
BDBM413455
PNG
((R)-7-methyl-2-((7-methyl-[1,2,4]triazolo[1,5-a]py...)
Show SMILES Cc1cc2ncnn2cc1Nc1ncc2n(C)c(=O)n([C@@H]3CCCOC3)c2n1
Show InChI InChI=1S/C18H20N8O2/c1-11-6-15-20-10-21-25(15)8-13(11)22-17-19-7-14-16(23-17)26(18(27)24(14)2)12-4-3-5-28-9-12/h6-8,10,12H,3-5,9H2,1-2H3,(H,19,22,23)/t12-/m1/s1
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n/an/a 6.31E+3n/an/an/an/an/an/a



AstraZeneca AB

US Patent


Assay Description
The inhibitory activity of compounds against AURKA, AURKB, JAK1, JAK2 and JAK3 was determined in Z′-LYTEŽ assays run by ThermoFisher Scientific...


US Patent US10407446 (2019)


BindingDB Entry DOI: 10.7270/Q2MS3W4T
More data for this
Ligand-Target Pair
Dual specificity protein kinase TTK


(Homo sapiens (Human))
BDBM413454
PNG
((S)-7-methyl-2-((7-methyl-[1,2,4]triazolo[1,5-a]py...)
Show SMILES Cc1cc2ncnn2cc1Nc1ncc2n(C)c(=O)n([C@H]3CCCOC3)c2n1
Show InChI InChI=1S/C18H20N8O2/c1-11-6-15-20-10-21-25(15)8-13(11)22-17-19-7-14-16(23-17)26(18(27)24(14)2)12-4-3-5-28-9-12/h6-8,10,12H,3-5,9H2,1-2H3,(H,19,22,23)/t12-/m0/s1
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n/an/a 6.31E+3n/an/an/an/an/an/a



AstraZeneca AB

US Patent


Assay Description
The inhibitory activity of compounds against AURKA, AURKB, JAK1, JAK2 and JAK3 was determined in Z′-LYTEŽ assays run by ThermoFisher Scientific...


US Patent US10407446 (2019)


BindingDB Entry DOI: 10.7270/Q2MS3W4T
More data for this
Ligand-Target Pair
Dual specificity protein kinase TTK


(Homo sapiens (Human))
BDBM413458
PNG
((S)-7-methyl-2-((7-methyl-[1,2,4]triazolo[1,5-a]py...)
Show SMILES Cc1cc2ncnn2cc1Nc1ncc2n(C)c(=O)n([C@H]3CCOC3)c2n1
Show InChI InChI=1S/C17H18N8O2/c1-10-5-14-19-9-20-24(14)7-12(10)21-16-18-6-13-15(22-16)25(17(26)23(13)2)11-3-4-27-8-11/h5-7,9,11H,3-4,8H2,1-2H3,(H,18,21,22)/t11-/m0/s1
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n/an/a<7.94E+3n/an/an/an/an/an/a



AstraZeneca AB

US Patent


Assay Description
The inhibitory activity of compounds against AURKA, AURKB, JAK1, JAK2 and JAK3 was determined in Z′-LYTEŽ assays run by ThermoFisher Scientific...


US Patent US10407446 (2019)


BindingDB Entry DOI: 10.7270/Q2MS3W4T
More data for this
Ligand-Target Pair
Dual specificity protein kinase TTK


(Homo sapiens (Human))
BDBM413451
PNG
(2-((2,7-dimethyl-[1,2,4]triazolo[1,5-a]pyridin-6-y...)
Show SMILES Cc1nc2cc(C)c(Nc3ncc4n(C)c(=O)n(C5CCOCC5)c4n3)cn2n1
Show InChI InChI=1S/C19H22N8O2/c1-11-8-16-21-12(2)24-26(16)10-14(11)22-18-20-9-15-17(23-18)27(19(28)25(15)3)13-4-6-29-7-5-13/h8-10,13H,4-7H2,1-3H3,(H,20,22,23)
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n/an/a 7.94E+3n/an/an/an/an/an/a



AstraZeneca AB

US Patent


Assay Description
The inhibitory activity of compounds against AURKA, AURKB, JAK1, JAK2 and JAK3 was determined in Z′-LYTEŽ assays run by ThermoFisher Scientific...


US Patent US10407446 (2019)


BindingDB Entry DOI: 10.7270/Q2MS3W4T
More data for this
Ligand-Target Pair
Aurora kinase B


(Homo sapiens (Human))
BDBM413448
PNG
(9-((1r,4r)-4-hydroxycyclohexyl)-7-methyl-2-((7-met...)
Show SMILES Cc1cc2ncnn2cc1Nc1ncc2n(C)c(=O)n([C@H]3CC[C@H](O)CC3)c2n1
Show InChI InChI=1S/C19H22N8O2/c1-11-7-16-21-10-22-26(16)9-14(11)23-18-20-8-15-17(24-18)27(19(29)25(15)2)12-3-5-13(28)6-4-12/h7-10,12-13,28H,3-6H2,1-2H3,(H,20,23,24)/t12-,13-
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AstraZeneca AB

US Patent


Assay Description
The inhibitory activity of compounds against AURKA, AURKB, JAK1, JAK2 and JAK3 was determined in Z′-LYTEŽ assays run by ThermoFisher Scientific...


US Patent US10407446 (2019)


BindingDB Entry DOI: 10.7270/Q2MS3W4T
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))
BDBM413449
PNG
(9-((1s,4s)-4-hydroxycyclohexyl)-7-methyl-2-((7-met...)
Show SMILES Cc1cc2ncnn2cc1Nc1ncc2n(C)c(=O)n([C@@H]3CC[C@H](O)CC3)c2n1
Show InChI InChI=1S/C19H22N8O2/c1-11-7-16-21-10-22-26(16)9-14(11)23-18-20-8-15-17(24-18)27(19(29)25(15)2)12-3-5-13(28)6-4-12/h7-10,12-13,28H,3-6H2,1-2H3,(H,20,23,24)/t12-,13+
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AstraZeneca AB

US Patent


Assay Description
The inhibitory activity of compounds against AURKA, AURKB, JAK1, JAK2 and JAK3 was determined in Z′-LYTEŽ assays run by ThermoFisher Scientific...


US Patent US10407446 (2019)


BindingDB Entry DOI: 10.7270/Q2MS3W4T
More data for this
Ligand-Target Pair
Aurora kinase A/Targeting protein for Xklp2


(Homo sapiens (Human))
BDBM413450
PNG
(7-methyl-2-((7-methyl-[1,2,4]triazolo[1,5-a]pyridi...)
Show SMILES Cc1cc2ncnn2cc1Nc1ncc2n(C)c(=O)n(C3CCOCC3)c2n1
Show InChI InChI=1S/C18H20N8O2/c1-11-7-15-20-10-21-25(15)9-13(11)22-17-19-8-14-16(23-17)26(18(27)24(14)2)12-3-5-28-6-4-12/h7-10,12H,3-6H2,1-2H3,(H,19,22,23)
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AstraZeneca AB

US Patent


Assay Description
The inhibitory activity of compounds against AURKA, AURKB, JAK1, JAK2 and JAK3 was determined in Z′-LYTEŽ assays run by ThermoFisher Scientific...


US Patent US10407446 (2019)


BindingDB Entry DOI: 10.7270/Q2MS3W4T
More data for this
Ligand-Target Pair
Aurora kinase B


(Homo sapiens (Human))
BDBM413450
PNG
(7-methyl-2-((7-methyl-[1,2,4]triazolo[1,5-a]pyridi...)
Show SMILES Cc1cc2ncnn2cc1Nc1ncc2n(C)c(=O)n(C3CCOCC3)c2n1
Show InChI InChI=1S/C18H20N8O2/c1-11-7-15-20-10-21-25(15)9-13(11)22-17-19-8-14-16(23-17)26(18(27)24(14)2)12-3-5-28-6-4-12/h7-10,12H,3-6H2,1-2H3,(H,19,22,23)
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n/an/a<1.00E+4n/an/an/an/an/an/a



AstraZeneca AB

US Patent


Assay Description
The inhibitory activity of compounds against AURKA, AURKB, JAK1, JAK2 and JAK3 was determined in Z′-LYTEŽ assays run by ThermoFisher Scientific...


US Patent US10407446 (2019)


BindingDB Entry DOI: 10.7270/Q2MS3W4T
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM413451
PNG
(2-((2,7-dimethyl-[1,2,4]triazolo[1,5-a]pyridin-6-y...)
Show SMILES Cc1nc2cc(C)c(Nc3ncc4n(C)c(=O)n(C5CCOCC5)c4n3)cn2n1
Show InChI InChI=1S/C19H22N8O2/c1-11-8-16-21-12(2)24-26(16)10-14(11)22-18-20-9-15-17(23-18)27(19(28)25(15)3)13-4-6-29-7-5-13/h8-10,13H,4-7H2,1-3H3,(H,20,22,23)
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n/an/a<1.00E+4n/an/an/an/an/an/a



AstraZeneca AB

US Patent


Assay Description
The inhibitory activity of compounds against AURKA, AURKB, JAK1, JAK2 and JAK3 was determined in Z′-LYTEŽ assays run by ThermoFisher Scientific...


US Patent US10407446 (2019)


BindingDB Entry DOI: 10.7270/Q2MS3W4T
More data for this
Ligand-Target Pair
Aurora kinase B


(Homo sapiens (Human))
BDBM413452
PNG
(9-((1s,4s)-4-methoxycyclohexyl)-7-methyl-2-((7-met...)
Show SMILES CO[C@H]1CC[C@H](CC1)n1c2nc(Nc3cn4ncnc4cc3C)ncc2n(C)c1=O
Show InChI InChI=1S/C20H24N8O2/c1-12-8-17-22-11-23-27(17)10-15(12)24-19-21-9-16-18(25-19)28(20(29)26(16)2)13-4-6-14(30-3)7-5-13/h8-11,13-14H,4-7H2,1-3H3,(H,21,24,25)/t13-,14+
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AstraZeneca AB

US Patent


Assay Description
The inhibitory activity of compounds against AURKA, AURKB, JAK1, JAK2 and JAK3 was determined in Z′-LYTEŽ assays run by ThermoFisher Scientific...


US Patent US10407446 (2019)


BindingDB Entry DOI: 10.7270/Q2MS3W4T
More data for this
Ligand-Target Pair
Aurora kinase B


(Homo sapiens (Human))
BDBM413454
PNG
((S)-7-methyl-2-((7-methyl-[1,2,4]triazolo[1,5-a]py...)
Show SMILES Cc1cc2ncnn2cc1Nc1ncc2n(C)c(=O)n([C@H]3CCCOC3)c2n1
Show InChI InChI=1S/C18H20N8O2/c1-11-6-15-20-10-21-25(15)8-13(11)22-17-19-7-14-16(23-17)26(18(27)24(14)2)12-4-3-5-28-9-12/h6-8,10,12H,3-5,9H2,1-2H3,(H,19,22,23)/t12-/m0/s1
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AstraZeneca AB

US Patent


Assay Description
The inhibitory activity of compounds against AURKA, AURKB, JAK1, JAK2 and JAK3 was determined in Z′-LYTEŽ assays run by ThermoFisher Scientific...


US Patent US10407446 (2019)


BindingDB Entry DOI: 10.7270/Q2MS3W4T
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM413455
PNG
((R)-7-methyl-2-((7-methyl-[1,2,4]triazolo[1,5-a]py...)
Show SMILES Cc1cc2ncnn2cc1Nc1ncc2n(C)c(=O)n([C@@H]3CCCOC3)c2n1
Show InChI InChI=1S/C18H20N8O2/c1-11-6-15-20-10-21-25(15)8-13(11)22-17-19-7-14-16(23-17)26(18(27)24(14)2)12-4-3-5-28-9-12/h6-8,10,12H,3-5,9H2,1-2H3,(H,19,22,23)/t12-/m1/s1
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AstraZeneca AB

US Patent


Assay Description
The inhibitory activity of compounds against AURKA, AURKB, JAK1, JAK2 and JAK3 was determined in Z′-LYTEŽ assays run by ThermoFisher Scientific...


US Patent US10407446 (2019)


BindingDB Entry DOI: 10.7270/Q2MS3W4T
More data for this
Ligand-Target Pair
Aurora kinase A/Targeting protein for Xklp2


(Homo sapiens (Human))
BDBM413455
PNG
((R)-7-methyl-2-((7-methyl-[1,2,4]triazolo[1,5-a]py...)
Show SMILES Cc1cc2ncnn2cc1Nc1ncc2n(C)c(=O)n([C@@H]3CCCOC3)c2n1
Show InChI InChI=1S/C18H20N8O2/c1-11-6-15-20-10-21-25(15)8-13(11)22-17-19-7-14-16(23-17)26(18(27)24(14)2)12-4-3-5-28-9-12/h6-8,10,12H,3-5,9H2,1-2H3,(H,19,22,23)/t12-/m1/s1
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AstraZeneca AB

US Patent


Assay Description
The inhibitory activity of compounds against AURKA, AURKB, JAK1, JAK2 and JAK3 was determined in Z′-LYTEŽ assays run by ThermoFisher Scientific...


US Patent US10407446 (2019)


BindingDB Entry DOI: 10.7270/Q2MS3W4T
More data for this
Ligand-Target Pair
Aurora kinase B


(Homo sapiens (Human))
BDBM413455
PNG
((R)-7-methyl-2-((7-methyl-[1,2,4]triazolo[1,5-a]py...)
Show SMILES Cc1cc2ncnn2cc1Nc1ncc2n(C)c(=O)n([C@@H]3CCCOC3)c2n1
Show InChI InChI=1S/C18H20N8O2/c1-11-6-15-20-10-21-25(15)8-13(11)22-17-19-7-14-16(23-17)26(18(27)24(14)2)12-4-3-5-28-9-12/h6-8,10,12H,3-5,9H2,1-2H3,(H,19,22,23)/t12-/m1/s1
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AstraZeneca AB

US Patent


Assay Description
The inhibitory activity of compounds against AURKA, AURKB, JAK1, JAK2 and JAK3 was determined in Z′-LYTEŽ assays run by ThermoFisher Scientific...


US Patent US10407446 (2019)


BindingDB Entry DOI: 10.7270/Q2MS3W4T
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM413456
PNG
(9-((1r,4r)-4-hydroxy-4-methylcyclohexyl)-7-methyl-...)
Show SMILES Cc1cc2ncnn2cc1Nc1ncc2n(C)c(=O)n([C@H]3CC[C@](C)(O)CC3)c2n1
Show InChI InChI=1S/C20H24N8O2/c1-12-8-16-22-11-23-27(16)10-14(12)24-18-21-9-15-17(25-18)28(19(29)26(15)3)13-4-6-20(2,30)7-5-13/h8-11,13,30H,4-7H2,1-3H3,(H,21,24,25)/t13-,20-
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AstraZeneca AB

US Patent


Assay Description
The inhibitory activity of compounds against AURKA, AURKB, JAK1, JAK2 and JAK3 was determined in Z′-LYTEŽ assays run by ThermoFisher Scientific...


US Patent US10407446 (2019)


BindingDB Entry DOI: 10.7270/Q2MS3W4T
More data for this
Ligand-Target Pair
Aurora kinase A/Targeting protein for Xklp2


(Homo sapiens (Human))
BDBM413457
PNG
(9-((1s,4s)-4-hydroxy-4-methylcyclohexyl)-7-methyl-...)
Show SMILES Cc1cc2ncnn2cc1Nc1ncc2n(C)c(=O)n([C@H]3CC[C@@](C)(O)CC3)c2n1
Show InChI InChI=1S/C20H24N8O2/c1-12-8-16-22-11-23-27(16)10-14(12)24-18-21-9-15-17(25-18)28(19(29)26(15)3)13-4-6-20(2,30)7-5-13/h8-11,13,30H,4-7H2,1-3H3,(H,21,24,25)/t13-,20+
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AstraZeneca AB

US Patent


Assay Description
The inhibitory activity of compounds against AURKA, AURKB, JAK1, JAK2 and JAK3 was determined in Z′-LYTEŽ assays run by ThermoFisher Scientific...


US Patent US10407446 (2019)


BindingDB Entry DOI: 10.7270/Q2MS3W4T
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM413448
PNG
(9-((1r,4r)-4-hydroxycyclohexyl)-7-methyl-2-((7-met...)
Show SMILES Cc1cc2ncnn2cc1Nc1ncc2n(C)c(=O)n([C@H]3CC[C@H](O)CC3)c2n1
Show InChI InChI=1S/C19H22N8O2/c1-11-7-16-21-10-22-26(16)9-14(11)23-18-20-8-15-17(24-18)27(19(29)25(15)2)12-3-5-13(28)6-4-12/h7-10,12-13,28H,3-6H2,1-2H3,(H,20,23,24)/t12-,13-
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AstraZeneca AB

US Patent


Assay Description
The inhibitory activity of compounds against AURKA, AURKB, JAK1, JAK2 and JAK3 was determined in Z′-LYTEŽ assays run by ThermoFisher Scientific...


US Patent US10407446 (2019)


BindingDB Entry DOI: 10.7270/Q2MS3W4T
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM413450
PNG
(7-methyl-2-((7-methyl-[1,2,4]triazolo[1,5-a]pyridi...)
Show SMILES Cc1cc2ncnn2cc1Nc1ncc2n(C)c(=O)n(C3CCOCC3)c2n1
Show InChI InChI=1S/C18H20N8O2/c1-11-7-15-20-10-21-25(15)9-13(11)22-17-19-8-14-16(23-17)26(18(27)24(14)2)12-3-5-28-6-4-12/h7-10,12H,3-6H2,1-2H3,(H,19,22,23)
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AstraZeneca AB

US Patent


Assay Description
The inhibitory activity of compounds against AURKA, AURKB, JAK1, JAK2 and JAK3 was determined in Z′-LYTEŽ assays run by ThermoFisher Scientific...


US Patent US10407446 (2019)


BindingDB Entry DOI: 10.7270/Q2MS3W4T
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM413449
PNG
(9-((1s,4s)-4-hydroxycyclohexyl)-7-methyl-2-((7-met...)
Show SMILES Cc1cc2ncnn2cc1Nc1ncc2n(C)c(=O)n([C@@H]3CC[C@H](O)CC3)c2n1
Show InChI InChI=1S/C19H22N8O2/c1-11-7-16-21-10-22-26(16)9-14(11)23-18-20-8-15-17(24-18)27(19(29)25(15)2)12-3-5-13(28)6-4-12/h7-10,12-13,28H,3-6H2,1-2H3,(H,20,23,24)/t12-,13+
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AstraZeneca AB

US Patent


Assay Description
The inhibitory activity of compounds against AURKA, AURKB, JAK1, JAK2 and JAK3 was determined in Z′-LYTEŽ assays run by ThermoFisher Scientific...


US Patent US10407446 (2019)


BindingDB Entry DOI: 10.7270/Q2MS3W4T
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM413453
PNG
(9-((1r,4r)-methoxycyclohexyl)-7-methyl-2-((7-methy...)
Show SMILES CO[C@H]1CC[C@@H](CC1)n1c2nc(Nc3cn4ncnc4cc3C)ncc2n(C)c1=O
Show InChI InChI=1S/C20H24N8O2/c1-12-8-17-22-11-23-27(17)10-15(12)24-19-21-9-16-18(25-19)28(20(29)26(16)2)13-4-6-14(30-3)7-5-13/h8-11,13-14H,4-7H2,1-3H3,(H,21,24,25)/t13-,14-
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AstraZeneca AB

US Patent


Assay Description
The inhibitory activity of compounds against AURKA, AURKB, JAK1, JAK2 and JAK3 was determined in Z′-LYTEŽ assays run by ThermoFisher Scientific...


US Patent US10407446 (2019)


BindingDB Entry DOI: 10.7270/Q2MS3W4T
More data for this
Ligand-Target Pair
Aurora kinase B


(Homo sapiens (Human))
BDBM413453
PNG
(9-((1r,4r)-methoxycyclohexyl)-7-methyl-2-((7-methy...)
Show SMILES CO[C@H]1CC[C@@H](CC1)n1c2nc(Nc3cn4ncnc4cc3C)ncc2n(C)c1=O
Show InChI InChI=1S/C20H24N8O2/c1-12-8-17-22-11-23-27(17)10-15(12)24-19-21-9-16-18(25-19)28(20(29)26(16)2)13-4-6-14(30-3)7-5-13/h8-11,13-14H,4-7H2,1-3H3,(H,21,24,25)/t13-,14-
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AstraZeneca AB

US Patent


Assay Description
The inhibitory activity of compounds against AURKA, AURKB, JAK1, JAK2 and JAK3 was determined in Z′-LYTEŽ assays run by ThermoFisher Scientific...


US Patent US10407446 (2019)


BindingDB Entry DOI: 10.7270/Q2MS3W4T
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM413456
PNG
(9-((1r,4r)-4-hydroxy-4-methylcyclohexyl)-7-methyl-...)
Show SMILES Cc1cc2ncnn2cc1Nc1ncc2n(C)c(=O)n([C@H]3CC[C@](C)(O)CC3)c2n1
Show InChI InChI=1S/C20H24N8O2/c1-12-8-16-22-11-23-27(16)10-14(12)24-18-21-9-15-17(25-18)28(19(29)26(15)3)13-4-6-20(2,30)7-5-13/h8-11,13,30H,4-7H2,1-3H3,(H,21,24,25)/t13-,20-
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AstraZeneca AB

US Patent


Assay Description
The inhibitory activity of compounds against AURKA, AURKB, JAK1, JAK2 and JAK3 was determined in Z′-LYTEŽ assays run by ThermoFisher Scientific...


US Patent US10407446 (2019)


BindingDB Entry DOI: 10.7270/Q2MS3W4T
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM413457
PNG
(9-((1s,4s)-4-hydroxy-4-methylcyclohexyl)-7-methyl-...)
Show SMILES Cc1cc2ncnn2cc1Nc1ncc2n(C)c(=O)n([C@H]3CC[C@@](C)(O)CC3)c2n1
Show InChI InChI=1S/C20H24N8O2/c1-12-8-16-22-11-23-27(16)10-14(12)24-18-21-9-15-17(25-18)28(19(29)26(15)3)13-4-6-20(2,30)7-5-13/h8-11,13,30H,4-7H2,1-3H3,(H,21,24,25)/t13-,20+
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AstraZeneca AB

US Patent


Assay Description
The inhibitory activity of compounds against AURKA, AURKB, JAK1, JAK2 and JAK3 was determined in Z′-LYTEŽ assays run by ThermoFisher Scientific...


US Patent US10407446 (2019)


BindingDB Entry DOI: 10.7270/Q2MS3W4T
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM413457
PNG
(9-((1s,4s)-4-hydroxy-4-methylcyclohexyl)-7-methyl-...)
Show SMILES Cc1cc2ncnn2cc1Nc1ncc2n(C)c(=O)n([C@H]3CC[C@@](C)(O)CC3)c2n1
Show InChI InChI=1S/C20H24N8O2/c1-12-8-16-22-11-23-27(16)10-14(12)24-18-21-9-15-17(25-18)28(19(29)26(15)3)13-4-6-20(2,30)7-5-13/h8-11,13,30H,4-7H2,1-3H3,(H,21,24,25)/t13-,20+
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AstraZeneca AB

US Patent


Assay Description
The inhibitory activity of compounds against AURKA, AURKB, JAK1, JAK2 and JAK3 was determined in Z′-LYTEŽ assays run by ThermoFisher Scientific...


US Patent US10407446 (2019)


BindingDB Entry DOI: 10.7270/Q2MS3W4T
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM413458
PNG
((S)-7-methyl-2-((7-methyl-[1,2,4]triazolo[1,5-a]py...)
Show SMILES Cc1cc2ncnn2cc1Nc1ncc2n(C)c(=O)n([C@H]3CCOC3)c2n1
Show InChI InChI=1S/C17H18N8O2/c1-10-5-14-19-9-20-24(14)7-12(10)21-16-18-6-13-15(22-16)25(17(26)23(13)2)11-3-4-27-8-11/h5-7,9,11H,3-4,8H2,1-2H3,(H,18,21,22)/t11-/m0/s1
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AstraZeneca AB

US Patent


Assay Description
The inhibitory activity of compounds against AURKA, AURKB, JAK1, JAK2 and JAK3 was determined in Z′-LYTEŽ assays run by ThermoFisher Scientific...


US Patent US10407446 (2019)


BindingDB Entry DOI: 10.7270/Q2MS3W4T
More data for this
Ligand-Target Pair
Aurora kinase A/Targeting protein for Xklp2


(Homo sapiens (Human))
BDBM413458
PNG
((S)-7-methyl-2-((7-methyl-[1,2,4]triazolo[1,5-a]py...)
Show SMILES Cc1cc2ncnn2cc1Nc1ncc2n(C)c(=O)n([C@H]3CCOC3)c2n1
Show InChI InChI=1S/C17H18N8O2/c1-10-5-14-19-9-20-24(14)7-12(10)21-16-18-6-13-15(22-16)25(17(26)23(13)2)11-3-4-27-8-11/h5-7,9,11H,3-4,8H2,1-2H3,(H,18,21,22)/t11-/m0/s1
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AstraZeneca AB

US Patent


Assay Description
The inhibitory activity of compounds against AURKA, AURKB, JAK1, JAK2 and JAK3 was determined in Z′-LYTEŽ assays run by ThermoFisher Scientific...


US Patent US10407446 (2019)


BindingDB Entry DOI: 10.7270/Q2MS3W4T
More data for this
Ligand-Target Pair
Aurora kinase B


(Homo sapiens (Human))
BDBM413458
PNG
((S)-7-methyl-2-((7-methyl-[1,2,4]triazolo[1,5-a]py...)
Show SMILES Cc1cc2ncnn2cc1Nc1ncc2n(C)c(=O)n([C@H]3CCOC3)c2n1
Show InChI InChI=1S/C17H18N8O2/c1-10-5-14-19-9-20-24(14)7-12(10)21-16-18-6-13-15(22-16)25(17(26)23(13)2)11-3-4-27-8-11/h5-7,9,11H,3-4,8H2,1-2H3,(H,18,21,22)/t11-/m0/s1
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AstraZeneca AB

US Patent


Assay Description
The inhibitory activity of compounds against AURKA, AURKB, JAK1, JAK2 and JAK3 was determined in Z′-LYTEŽ assays run by ThermoFisher Scientific...


US Patent US10407446 (2019)


BindingDB Entry DOI: 10.7270/Q2MS3W4T
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM413459
PNG
(9-((1s,4s)-4-hydroxy-1-methylcyclohexyl)-7-methyl-...)
Show SMILES Cc1cc2ncnn2cc1Nc1ncc2n(C)c(=O)n(c2n1)[C@]1(C)CC[C@H](O)CC1
Show InChI InChI=1S/C20H24N8O2/c1-12-8-16-22-11-23-27(16)10-14(12)24-18-21-9-15-17(25-18)28(19(30)26(15)3)20(2)6-4-13(29)5-7-20/h8-11,13,29H,4-7H2,1-3H3,(H,21,24,25)/t13-,20+
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AstraZeneca AB

US Patent


Assay Description
The inhibitory activity of compounds against AURKA, AURKB, JAK1, JAK2 and JAK3 was determined in Z′-LYTEŽ assays run by ThermoFisher Scientific...


US Patent US10407446 (2019)


BindingDB Entry DOI: 10.7270/Q2MS3W4T
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))
BDBM413459
PNG
(9-((1s,4s)-4-hydroxy-1-methylcyclohexyl)-7-methyl-...)
Show SMILES Cc1cc2ncnn2cc1Nc1ncc2n(C)c(=O)n(c2n1)[C@]1(C)CC[C@H](O)CC1
Show InChI InChI=1S/C20H24N8O2/c1-12-8-16-22-11-23-27(16)10-14(12)24-18-21-9-15-17(25-18)28(19(30)26(15)3)20(2)6-4-13(29)5-7-20/h8-11,13,29H,4-7H2,1-3H3,(H,21,24,25)/t13-,20+
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AstraZeneca AB

US Patent


Assay Description
The inhibitory activity of compounds against AURKA, AURKB, JAK1, JAK2 and JAK3 was determined in Z′-LYTEŽ assays run by ThermoFisher Scientific...


US Patent US10407446 (2019)


BindingDB Entry DOI: 10.7270/Q2MS3W4T
More data for this
Ligand-Target Pair
Aurora kinase B


(Homo sapiens (Human))
BDBM413459
PNG
(9-((1s,4s)-4-hydroxy-1-methylcyclohexyl)-7-methyl-...)
Show SMILES Cc1cc2ncnn2cc1Nc1ncc2n(C)c(=O)n(c2n1)[C@]1(C)CC[C@H](O)CC1
Show InChI InChI=1S/C20H24N8O2/c1-12-8-16-22-11-23-27(16)10-14(12)24-18-21-9-15-17(25-18)28(19(30)26(15)3)20(2)6-4-13(29)5-7-20/h8-11,13,29H,4-7H2,1-3H3,(H,21,24,25)/t13-,20+
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AstraZeneca AB

US Patent


Assay Description
The inhibitory activity of compounds against AURKA, AURKB, JAK1, JAK2 and JAK3 was determined in Z′-LYTEŽ assays run by ThermoFisher Scientific...


US Patent US10407446 (2019)


BindingDB Entry DOI: 10.7270/Q2MS3W4T
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM413460
PNG
(9-cyclohexyl-7-methyl-2-((7-methyl-[1,2,4]triazolo...)
Show SMILES Cc1cc2ncnn2cc1Nc1ncc2n(C)c(=O)n(C3CCCCC3)c2n1
Show InChI InChI=1S/C19H22N8O/c1-12-8-16-21-11-22-26(16)10-14(12)23-18-20-9-15-17(24-18)27(19(28)25(15)2)13-6-4-3-5-7-13/h8-11,13H,3-7H2,1-2H3,(H,20,23,24)
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AstraZeneca AB

US Patent


Assay Description
The inhibitory activity of compounds against AURKA, AURKB, JAK1, JAK2 and JAK3 was determined in Z′-LYTEŽ assays run by ThermoFisher Scientific...


US Patent US10407446 (2019)


BindingDB Entry DOI: 10.7270/Q2MS3W4T
More data for this
Ligand-Target Pair
Aurora kinase B


(Homo sapiens (Human))
BDBM413460
PNG
(9-cyclohexyl-7-methyl-2-((7-methyl-[1,2,4]triazolo...)
Show SMILES Cc1cc2ncnn2cc1Nc1ncc2n(C)c(=O)n(C3CCCCC3)c2n1
Show InChI InChI=1S/C19H22N8O/c1-12-8-16-21-11-22-26(16)10-14(12)23-18-20-9-15-17(24-18)27(19(28)25(15)2)13-6-4-3-5-7-13/h8-11,13H,3-7H2,1-2H3,(H,20,23,24)
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AstraZeneca AB

US Patent


Assay Description
The inhibitory activity of compounds against AURKA, AURKB, JAK1, JAK2 and JAK3 was determined in Z′-LYTEŽ assays run by ThermoFisher Scientific...


US Patent US10407446 (2019)


BindingDB Entry DOI: 10.7270/Q2MS3W4T
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))
BDBM413450
PNG
(7-methyl-2-((7-methyl-[1,2,4]triazolo[1,5-a]pyridi...)
Show SMILES Cc1cc2ncnn2cc1Nc1ncc2n(C)c(=O)n(C3CCOCC3)c2n1
Show InChI InChI=1S/C18H20N8O2/c1-11-7-15-20-10-21-25(15)9-13(11)22-17-19-8-14-16(23-17)26(18(27)24(14)2)12-3-5-28-6-4-12/h7-10,12H,3-6H2,1-2H3,(H,19,22,23)
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AstraZeneca AB

US Patent


Assay Description
The inhibitory activity of compounds against AURKA, AURKB, JAK1, JAK2 and JAK3 was determined in Z′-LYTEŽ assays run by ThermoFisher Scientific...


US Patent US10407446 (2019)


BindingDB Entry DOI: 10.7270/Q2MS3W4T
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))
BDBM413451
PNG
(2-((2,7-dimethyl-[1,2,4]triazolo[1,5-a]pyridin-6-y...)
Show SMILES Cc1nc2cc(C)c(Nc3ncc4n(C)c(=O)n(C5CCOCC5)c4n3)cn2n1
Show InChI InChI=1S/C19H22N8O2/c1-11-8-16-21-12(2)24-26(16)10-14(11)22-18-20-9-15-17(23-18)27(19(28)25(15)3)13-4-6-29-7-5-13/h8-10,13H,4-7H2,1-3H3,(H,20,22,23)
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AstraZeneca AB

US Patent


Assay Description
The inhibitory activity of compounds against AURKA, AURKB, JAK1, JAK2 and JAK3 was determined in Z′-LYTEŽ assays run by ThermoFisher Scientific...


US Patent US10407446 (2019)


BindingDB Entry DOI: 10.7270/Q2MS3W4T
More data for this
Ligand-Target Pair
Aurora kinase A/Targeting protein for Xklp2


(Homo sapiens (Human))
BDBM413452
PNG
(9-((1s,4s)-4-methoxycyclohexyl)-7-methyl-2-((7-met...)
Show SMILES CO[C@H]1CC[C@H](CC1)n1c2nc(Nc3cn4ncnc4cc3C)ncc2n(C)c1=O
Show InChI InChI=1S/C20H24N8O2/c1-12-8-17-22-11-23-27(17)10-15(12)24-19-21-9-16-18(25-19)28(20(29)26(16)2)13-4-6-14(30-3)7-5-13/h8-11,13-14H,4-7H2,1-3H3,(H,21,24,25)/t13-,14+
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AstraZeneca AB

US Patent


Assay Description
The inhibitory activity of compounds against AURKA, AURKB, JAK1, JAK2 and JAK3 was determined in Z′-LYTEŽ assays run by ThermoFisher Scientific...


US Patent US10407446 (2019)


BindingDB Entry DOI: 10.7270/Q2MS3W4T
More data for this
Ligand-Target Pair
Aurora kinase A/Targeting protein for Xklp2


(Homo sapiens (Human))
BDBM413454
PNG
((S)-7-methyl-2-((7-methyl-[1,2,4]triazolo[1,5-a]py...)
Show SMILES Cc1cc2ncnn2cc1Nc1ncc2n(C)c(=O)n([C@H]3CCCOC3)c2n1
Show InChI InChI=1S/C18H20N8O2/c1-11-6-15-20-10-21-25(15)8-13(11)22-17-19-7-14-16(23-17)26(18(27)24(14)2)12-4-3-5-28-9-12/h6-8,10,12H,3-5,9H2,1-2H3,(H,19,22,23)/t12-/m0/s1
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AstraZeneca AB

US Patent


Assay Description
The inhibitory activity of compounds against AURKA, AURKB, JAK1, JAK2 and JAK3 was determined in Z′-LYTEŽ assays run by ThermoFisher Scientific...


US Patent US10407446 (2019)


BindingDB Entry DOI: 10.7270/Q2MS3W4T
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM413455
PNG
((R)-7-methyl-2-((7-methyl-[1,2,4]triazolo[1,5-a]py...)
Show SMILES Cc1cc2ncnn2cc1Nc1ncc2n(C)c(=O)n([C@@H]3CCCOC3)c2n1
Show InChI InChI=1S/C18H20N8O2/c1-11-6-15-20-10-21-25(15)8-13(11)22-17-19-7-14-16(23-17)26(18(27)24(14)2)12-4-3-5-28-9-12/h6-8,10,12H,3-5,9H2,1-2H3,(H,19,22,23)/t12-/m1/s1
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AstraZeneca AB

US Patent


Assay Description
The inhibitory activity of compounds against AURKA, AURKB, JAK1, JAK2 and JAK3 was determined in Z′-LYTEŽ assays run by ThermoFisher Scientific...


US Patent US10407446 (2019)


BindingDB Entry DOI: 10.7270/Q2MS3W4T
More data for this
Ligand-Target Pair
Aurora kinase A/Targeting protein for Xklp2


(Homo sapiens (Human))
BDBM413456
PNG
(9-((1r,4r)-4-hydroxy-4-methylcyclohexyl)-7-methyl-...)
Show SMILES Cc1cc2ncnn2cc1Nc1ncc2n(C)c(=O)n([C@H]3CC[C@](C)(O)CC3)c2n1
Show InChI InChI=1S/C20H24N8O2/c1-12-8-16-22-11-23-27(16)10-14(12)24-18-21-9-15-17(25-18)28(19(29)26(15)3)13-4-6-20(2,30)7-5-13/h8-11,13,30H,4-7H2,1-3H3,(H,21,24,25)/t13-,20-
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AstraZeneca AB

US Patent


Assay Description
The inhibitory activity of compounds against AURKA, AURKB, JAK1, JAK2 and JAK3 was determined in Z′-LYTEŽ assays run by ThermoFisher Scientific...


US Patent US10407446 (2019)


BindingDB Entry DOI: 10.7270/Q2MS3W4T
More data for this
Ligand-Target Pair
Aurora kinase B


(Homo sapiens (Human))
BDBM413456
PNG
(9-((1r,4r)-4-hydroxy-4-methylcyclohexyl)-7-methyl-...)
Show SMILES Cc1cc2ncnn2cc1Nc1ncc2n(C)c(=O)n([C@H]3CC[C@](C)(O)CC3)c2n1
Show InChI InChI=1S/C20H24N8O2/c1-12-8-16-22-11-23-27(16)10-14(12)24-18-21-9-15-17(25-18)28(19(29)26(15)3)13-4-6-20(2,30)7-5-13/h8-11,13,30H,4-7H2,1-3H3,(H,21,24,25)/t13-,20-
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AstraZeneca AB

US Patent


Assay Description
The inhibitory activity of compounds against AURKA, AURKB, JAK1, JAK2 and JAK3 was determined in Z′-LYTEŽ assays run by ThermoFisher Scientific...


US Patent US10407446 (2019)


BindingDB Entry DOI: 10.7270/Q2MS3W4T
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM413458
PNG
((S)-7-methyl-2-((7-methyl-[1,2,4]triazolo[1,5-a]py...)
Show SMILES Cc1cc2ncnn2cc1Nc1ncc2n(C)c(=O)n([C@H]3CCOC3)c2n1
Show InChI InChI=1S/C17H18N8O2/c1-10-5-14-19-9-20-24(14)7-12(10)21-16-18-6-13-15(22-16)25(17(26)23(13)2)11-3-4-27-8-11/h5-7,9,11H,3-4,8H2,1-2H3,(H,18,21,22)/t11-/m0/s1
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AstraZeneca AB

US Patent


Assay Description
The inhibitory activity of compounds against AURKA, AURKB, JAK1, JAK2 and JAK3 was determined in Z′-LYTEŽ assays run by ThermoFisher Scientific...


US Patent US10407446 (2019)


BindingDB Entry DOI: 10.7270/Q2MS3W4T
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM413459
PNG
(9-((1s,4s)-4-hydroxy-1-methylcyclohexyl)-7-methyl-...)
Show SMILES Cc1cc2ncnn2cc1Nc1ncc2n(C)c(=O)n(c2n1)[C@]1(C)CC[C@H](O)CC1
Show InChI InChI=1S/C20H24N8O2/c1-12-8-16-22-11-23-27(16)10-14(12)24-18-21-9-15-17(25-18)28(19(30)26(15)3)20(2)6-4-13(29)5-7-20/h8-11,13,29H,4-7H2,1-3H3,(H,21,24,25)/t13-,20+
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AstraZeneca AB

US Patent


Assay Description
The inhibitory activity of compounds against AURKA, AURKB, JAK1, JAK2 and JAK3 was determined in Z′-LYTEŽ assays run by ThermoFisher Scientific...


US Patent US10407446 (2019)


BindingDB Entry DOI: 10.7270/Q2MS3W4T
More data for this
Ligand-Target Pair
Aurora kinase A/Targeting protein for Xklp2


(Homo sapiens (Human))
BDBM413459
PNG
(9-((1s,4s)-4-hydroxy-1-methylcyclohexyl)-7-methyl-...)
Show SMILES Cc1cc2ncnn2cc1Nc1ncc2n(C)c(=O)n(c2n1)[C@]1(C)CC[C@H](O)CC1
Show InChI InChI=1S/C20H24N8O2/c1-12-8-16-22-11-23-27(16)10-14(12)24-18-21-9-15-17(25-18)28(19(30)26(15)3)20(2)6-4-13(29)5-7-20/h8-11,13,29H,4-7H2,1-3H3,(H,21,24,25)/t13-,20+
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AstraZeneca AB

US Patent


Assay Description
The inhibitory activity of compounds against AURKA, AURKB, JAK1, JAK2 and JAK3 was determined in Z′-LYTEŽ assays run by ThermoFisher Scientific...


US Patent US10407446 (2019)


BindingDB Entry DOI: 10.7270/Q2MS3W4T
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM413460
PNG
(9-cyclohexyl-7-methyl-2-((7-methyl-[1,2,4]triazolo...)
Show SMILES Cc1cc2ncnn2cc1Nc1ncc2n(C)c(=O)n(C3CCCCC3)c2n1
Show InChI InChI=1S/C19H22N8O/c1-12-8-16-21-11-22-26(16)10-14(12)23-18-20-9-15-17(24-18)27(19(28)25(15)2)13-6-4-3-5-7-13/h8-11,13H,3-7H2,1-2H3,(H,20,23,24)
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AstraZeneca AB

US Patent


Assay Description
The inhibitory activity of compounds against AURKA, AURKB, JAK1, JAK2 and JAK3 was determined in Z′-LYTEŽ assays run by ThermoFisher Scientific...


US Patent US10407446 (2019)


BindingDB Entry DOI: 10.7270/Q2MS3W4T
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))
BDBM413460
PNG
(9-cyclohexyl-7-methyl-2-((7-methyl-[1,2,4]triazolo...)
Show SMILES Cc1cc2ncnn2cc1Nc1ncc2n(C)c(=O)n(C3CCCCC3)c2n1
Show InChI InChI=1S/C19H22N8O/c1-12-8-16-21-11-22-26(16)10-14(12)23-18-20-9-15-17(24-18)27(19(28)25(15)2)13-6-4-3-5-7-13/h8-11,13H,3-7H2,1-2H3,(H,20,23,24)
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AstraZeneca AB

US Patent


Assay Description
The inhibitory activity of compounds against AURKA, AURKB, JAK1, JAK2 and JAK3 was determined in Z′-LYTEŽ assays run by ThermoFisher Scientific...


US Patent US10407446 (2019)


BindingDB Entry DOI: 10.7270/Q2MS3W4T
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM413452
PNG
(9-((1s,4s)-4-methoxycyclohexyl)-7-methyl-2-((7-met...)
Show SMILES CO[C@H]1CC[C@H](CC1)n1c2nc(Nc3cn4ncnc4cc3C)ncc2n(C)c1=O
Show InChI InChI=1S/C20H24N8O2/c1-12-8-17-22-11-23-27(17)10-15(12)24-19-21-9-16-18(25-19)28(20(29)26(16)2)13-4-6-14(30-3)7-5-13/h8-11,13-14H,4-7H2,1-3H3,(H,21,24,25)/t13-,14+
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AstraZeneca AB

US Patent


Assay Description
The inhibitory activity of compounds against AURKA, AURKB, JAK1, JAK2 and JAK3 was determined in Z′-LYTEŽ assays run by ThermoFisher Scientific...


US Patent US10407446 (2019)


BindingDB Entry DOI: 10.7270/Q2MS3W4T
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))
BDBM413452
PNG
(9-((1s,4s)-4-methoxycyclohexyl)-7-methyl-2-((7-met...)
Show SMILES CO[C@H]1CC[C@H](CC1)n1c2nc(Nc3cn4ncnc4cc3C)ncc2n(C)c1=O
Show InChI InChI=1S/C20H24N8O2/c1-12-8-17-22-11-23-27(17)10-15(12)24-19-21-9-16-18(25-19)28(20(29)26(16)2)13-4-6-14(30-3)7-5-13/h8-11,13-14H,4-7H2,1-3H3,(H,21,24,25)/t13-,14+
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AstraZeneca AB

US Patent


Assay Description
The inhibitory activity of compounds against AURKA, AURKB, JAK1, JAK2 and JAK3 was determined in Z′-LYTEŽ assays run by ThermoFisher Scientific...


US Patent US10407446 (2019)


BindingDB Entry DOI: 10.7270/Q2MS3W4T
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM413448
PNG
(9-((1r,4r)-4-hydroxycyclohexyl)-7-methyl-2-((7-met...)
Show SMILES Cc1cc2ncnn2cc1Nc1ncc2n(C)c(=O)n([C@H]3CC[C@H](O)CC3)c2n1
Show InChI InChI=1S/C19H22N8O2/c1-11-7-16-21-10-22-26(16)9-14(11)23-18-20-8-15-17(24-18)27(19(29)25(15)2)12-3-5-13(28)6-4-12/h7-10,12-13,28H,3-6H2,1-2H3,(H,20,23,24)/t12-,13-
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AstraZeneca AB

US Patent


Assay Description
The inhibitory activity of compounds against AURKA, AURKB, JAK1, JAK2 and JAK3 was determined in Z′-LYTEŽ assays run by ThermoFisher Scientific...


US Patent US10407446 (2019)


BindingDB Entry DOI: 10.7270/Q2MS3W4T
More data for this
Ligand-Target Pair
Aurora kinase A/Targeting protein for Xklp2


(Homo sapiens (Human))
BDBM413449
PNG
(9-((1s,4s)-4-hydroxycyclohexyl)-7-methyl-2-((7-met...)
Show SMILES Cc1cc2ncnn2cc1Nc1ncc2n(C)c(=O)n([C@@H]3CC[C@H](O)CC3)c2n1
Show InChI InChI=1S/C19H22N8O2/c1-11-7-16-21-10-22-26(16)9-14(11)23-18-20-8-15-17(24-18)27(19(29)25(15)2)12-3-5-13(28)6-4-12/h7-10,12-13,28H,3-6H2,1-2H3,(H,20,23,24)/t12-,13+
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AstraZeneca AB

US Patent


Assay Description
The inhibitory activity of compounds against AURKA, AURKB, JAK1, JAK2 and JAK3 was determined in Z′-LYTEŽ assays run by ThermoFisher Scientific...


US Patent US10407446 (2019)


BindingDB Entry DOI: 10.7270/Q2MS3W4T
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM413450
PNG
(7-methyl-2-((7-methyl-[1,2,4]triazolo[1,5-a]pyridi...)
Show SMILES Cc1cc2ncnn2cc1Nc1ncc2n(C)c(=O)n(C3CCOCC3)c2n1
Show InChI InChI=1S/C18H20N8O2/c1-11-7-15-20-10-21-25(15)9-13(11)22-17-19-8-14-16(23-17)26(18(27)24(14)2)12-3-5-28-6-4-12/h7-10,12H,3-6H2,1-2H3,(H,19,22,23)
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n/an/a<1.00E+4n/an/an/an/an/an/a



AstraZeneca AB

US Patent


Assay Description
The inhibitory activity of compounds against AURKA, AURKB, JAK1, JAK2 and JAK3 was determined in Z′-LYTEŽ assays run by ThermoFisher Scientific...


US Patent US10407446 (2019)


BindingDB Entry DOI: 10.7270/Q2MS3W4T
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))
BDBM413453
PNG
(9-((1r,4r)-methoxycyclohexyl)-7-methyl-2-((7-methy...)
Show SMILES CO[C@H]1CC[C@@H](CC1)n1c2nc(Nc3cn4ncnc4cc3C)ncc2n(C)c1=O
Show InChI InChI=1S/C20H24N8O2/c1-12-8-17-22-11-23-27(17)10-15(12)24-19-21-9-16-18(25-19)28(20(29)26(16)2)13-4-6-14(30-3)7-5-13/h8-11,13-14H,4-7H2,1-3H3,(H,21,24,25)/t13-,14-
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AstraZeneca AB

US Patent


Assay Description
The inhibitory activity of compounds against AURKA, AURKB, JAK1, JAK2 and JAK3 was determined in Z′-LYTEŽ assays run by ThermoFisher Scientific...


US Patent US10407446 (2019)


BindingDB Entry DOI: 10.7270/Q2MS3W4T
More data for this
Ligand-Target Pair
Aurora kinase A/Targeting protein for Xklp2


(Homo sapiens (Human))
BDBM413453
PNG
(9-((1r,4r)-methoxycyclohexyl)-7-methyl-2-((7-methy...)
Show SMILES CO[C@H]1CC[C@@H](CC1)n1c2nc(Nc3cn4ncnc4cc3C)ncc2n(C)c1=O
Show InChI InChI=1S/C20H24N8O2/c1-12-8-17-22-11-23-27(17)10-15(12)24-19-21-9-16-18(25-19)28(20(29)26(16)2)13-4-6-14(30-3)7-5-13/h8-11,13-14H,4-7H2,1-3H3,(H,21,24,25)/t13-,14-
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AstraZeneca AB

US Patent


Assay Description
The inhibitory activity of compounds against AURKA, AURKB, JAK1, JAK2 and JAK3 was determined in Z′-LYTEŽ assays run by ThermoFisher Scientific...


US Patent US10407446 (2019)


BindingDB Entry DOI: 10.7270/Q2MS3W4T
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))
BDBM413454
PNG
((S)-7-methyl-2-((7-methyl-[1,2,4]triazolo[1,5-a]py...)
Show SMILES Cc1cc2ncnn2cc1Nc1ncc2n(C)c(=O)n([C@H]3CCCOC3)c2n1
Show InChI InChI=1S/C18H20N8O2/c1-11-6-15-20-10-21-25(15)8-13(11)22-17-19-7-14-16(23-17)26(18(27)24(14)2)12-4-3-5-28-9-12/h6-8,10,12H,3-5,9H2,1-2H3,(H,19,22,23)/t12-/m0/s1
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AstraZeneca AB

US Patent


Assay Description
The inhibitory activity of compounds against AURKA, AURKB, JAK1, JAK2 and JAK3 was determined in Z′-LYTEŽ assays run by ThermoFisher Scientific...


US Patent US10407446 (2019)


BindingDB Entry DOI: 10.7270/Q2MS3W4T
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))
BDBM413455
PNG
((R)-7-methyl-2-((7-methyl-[1,2,4]triazolo[1,5-a]py...)
Show SMILES Cc1cc2ncnn2cc1Nc1ncc2n(C)c(=O)n([C@@H]3CCCOC3)c2n1
Show InChI InChI=1S/C18H20N8O2/c1-11-6-15-20-10-21-25(15)8-13(11)22-17-19-7-14-16(23-17)26(18(27)24(14)2)12-4-3-5-28-9-12/h6-8,10,12H,3-5,9H2,1-2H3,(H,19,22,23)/t12-/m1/s1
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AstraZeneca AB

US Patent


Assay Description
The inhibitory activity of compounds against AURKA, AURKB, JAK1, JAK2 and JAK3 was determined in Z′-LYTEŽ assays run by ThermoFisher Scientific...


US Patent US10407446 (2019)


BindingDB Entry DOI: 10.7270/Q2MS3W4T
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))
BDBM413456
PNG
(9-((1r,4r)-4-hydroxy-4-methylcyclohexyl)-7-methyl-...)
Show SMILES Cc1cc2ncnn2cc1Nc1ncc2n(C)c(=O)n([C@H]3CC[C@](C)(O)CC3)c2n1
Show InChI InChI=1S/C20H24N8O2/c1-12-8-16-22-11-23-27(16)10-14(12)24-18-21-9-15-17(25-18)28(19(29)26(15)3)13-4-6-20(2,30)7-5-13/h8-11,13,30H,4-7H2,1-3H3,(H,21,24,25)/t13-,20-
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AstraZeneca AB

US Patent


Assay Description
The inhibitory activity of compounds against AURKA, AURKB, JAK1, JAK2 and JAK3 was determined in Z′-LYTEŽ assays run by ThermoFisher Scientific...


US Patent US10407446 (2019)


BindingDB Entry DOI: 10.7270/Q2MS3W4T
More data for this
Ligand-Target Pair
Aurora kinase A/Targeting protein for Xklp2


(Homo sapiens (Human))
BDBM413448
PNG
(9-((1r,4r)-4-hydroxycyclohexyl)-7-methyl-2-((7-met...)
Show SMILES Cc1cc2ncnn2cc1Nc1ncc2n(C)c(=O)n([C@H]3CC[C@H](O)CC3)c2n1
Show InChI InChI=1S/C19H22N8O2/c1-11-7-16-21-10-22-26(16)9-14(11)23-18-20-8-15-17(24-18)27(19(29)25(15)2)12-3-5-13(28)6-4-12/h7-10,12-13,28H,3-6H2,1-2H3,(H,20,23,24)/t12-,13-
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AstraZeneca AB

US Patent


Assay Description
The inhibitory activity of compounds against AURKA, AURKB, JAK1, JAK2 and JAK3 was determined in Z′-LYTEŽ assays run by ThermoFisher Scientific...


US Patent US10407446 (2019)


BindingDB Entry DOI: 10.7270/Q2MS3W4T
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM413449
PNG
(9-((1s,4s)-4-hydroxycyclohexyl)-7-methyl-2-((7-met...)
Show SMILES Cc1cc2ncnn2cc1Nc1ncc2n(C)c(=O)n([C@@H]3CC[C@H](O)CC3)c2n1
Show InChI InChI=1S/C19H22N8O2/c1-11-7-16-21-10-22-26(16)9-14(11)23-18-20-8-15-17(24-18)27(19(29)25(15)2)12-3-5-13(28)6-4-12/h7-10,12-13,28H,3-6H2,1-2H3,(H,20,23,24)/t12-,13+
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AstraZeneca AB

US Patent


Assay Description
The inhibitory activity of compounds against AURKA, AURKB, JAK1, JAK2 and JAK3 was determined in Z′-LYTEŽ assays run by ThermoFisher Scientific...


US Patent US10407446 (2019)


BindingDB Entry DOI: 10.7270/Q2MS3W4T
More data for this
Ligand-Target Pair
Aurora kinase B


(Homo sapiens (Human))
BDBM413451
PNG
(2-((2,7-dimethyl-[1,2,4]triazolo[1,5-a]pyridin-6-y...)
Show SMILES Cc1nc2cc(C)c(Nc3ncc4n(C)c(=O)n(C5CCOCC5)c4n3)cn2n1
Show InChI InChI=1S/C19H22N8O2/c1-11-8-16-21-12(2)24-26(16)10-14(11)22-18-20-9-15-17(23-18)27(19(28)25(15)3)13-4-6-29-7-5-13/h8-10,13H,4-7H2,1-3H3,(H,20,22,23)
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AstraZeneca AB

US Patent


Assay Description
The inhibitory activity of compounds against AURKA, AURKB, JAK1, JAK2 and JAK3 was determined in Z′-LYTEŽ assays run by ThermoFisher Scientific...


US Patent US10407446 (2019)


BindingDB Entry DOI: 10.7270/Q2MS3W4T
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM413452
PNG
(9-((1s,4s)-4-methoxycyclohexyl)-7-methyl-2-((7-met...)
Show SMILES CO[C@H]1CC[C@H](CC1)n1c2nc(Nc3cn4ncnc4cc3C)ncc2n(C)c1=O
Show InChI InChI=1S/C20H24N8O2/c1-12-8-17-22-11-23-27(17)10-15(12)24-19-21-9-16-18(25-19)28(20(29)26(16)2)13-4-6-14(30-3)7-5-13/h8-11,13-14H,4-7H2,1-3H3,(H,21,24,25)/t13-,14+
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AstraZeneca AB

US Patent


Assay Description
The inhibitory activity of compounds against AURKA, AURKB, JAK1, JAK2 and JAK3 was determined in Z′-LYTEŽ assays run by ThermoFisher Scientific...


US Patent US10407446 (2019)


BindingDB Entry DOI: 10.7270/Q2MS3W4T
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM413454
PNG
((S)-7-methyl-2-((7-methyl-[1,2,4]triazolo[1,5-a]py...)
Show SMILES Cc1cc2ncnn2cc1Nc1ncc2n(C)c(=O)n([C@H]3CCCOC3)c2n1
Show InChI InChI=1S/C18H20N8O2/c1-11-6-15-20-10-21-25(15)8-13(11)22-17-19-7-14-16(23-17)26(18(27)24(14)2)12-4-3-5-28-9-12/h6-8,10,12H,3-5,9H2,1-2H3,(H,19,22,23)/t12-/m0/s1
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AstraZeneca AB

US Patent


Assay Description
The inhibitory activity of compounds against AURKA, AURKB, JAK1, JAK2 and JAK3 was determined in Z′-LYTEŽ assays run by ThermoFisher Scientific...


US Patent US10407446 (2019)


BindingDB Entry DOI: 10.7270/Q2MS3W4T
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM413454
PNG
((S)-7-methyl-2-((7-methyl-[1,2,4]triazolo[1,5-a]py...)
Show SMILES Cc1cc2ncnn2cc1Nc1ncc2n(C)c(=O)n([C@H]3CCCOC3)c2n1
Show InChI InChI=1S/C18H20N8O2/c1-11-6-15-20-10-21-25(15)8-13(11)22-17-19-7-14-16(23-17)26(18(27)24(14)2)12-4-3-5-28-9-12/h6-8,10,12H,3-5,9H2,1-2H3,(H,19,22,23)/t12-/m0/s1
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AstraZeneca AB

US Patent


Assay Description
The inhibitory activity of compounds against AURKA, AURKB, JAK1, JAK2 and JAK3 was determined in Z′-LYTEŽ assays run by ThermoFisher Scientific...


US Patent US10407446 (2019)


BindingDB Entry DOI: 10.7270/Q2MS3W4T
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))
BDBM413457
PNG
(9-((1s,4s)-4-hydroxy-4-methylcyclohexyl)-7-methyl-...)
Show SMILES Cc1cc2ncnn2cc1Nc1ncc2n(C)c(=O)n([C@H]3CC[C@@](C)(O)CC3)c2n1
Show InChI InChI=1S/C20H24N8O2/c1-12-8-16-22-11-23-27(16)10-14(12)24-18-21-9-15-17(25-18)28(19(29)26(15)3)13-4-6-20(2,30)7-5-13/h8-11,13,30H,4-7H2,1-3H3,(H,21,24,25)/t13-,20+
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AstraZeneca AB

US Patent


Assay Description
The inhibitory activity of compounds against AURKA, AURKB, JAK1, JAK2 and JAK3 was determined in Z′-LYTEŽ assays run by ThermoFisher Scientific...


US Patent US10407446 (2019)


BindingDB Entry DOI: 10.7270/Q2MS3W4T
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))
BDBM413458
PNG
((S)-7-methyl-2-((7-methyl-[1,2,4]triazolo[1,5-a]py...)
Show SMILES Cc1cc2ncnn2cc1Nc1ncc2n(C)c(=O)n([C@H]3CCOC3)c2n1
Show InChI InChI=1S/C17H18N8O2/c1-10-5-14-19-9-20-24(14)7-12(10)21-16-18-6-13-15(22-16)25(17(26)23(13)2)11-3-4-27-8-11/h5-7,9,11H,3-4,8H2,1-2H3,(H,18,21,22)/t11-/m0/s1
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AstraZeneca AB

US Patent


Assay Description
The inhibitory activity of compounds against AURKA, AURKB, JAK1, JAK2 and JAK3 was determined in Z′-LYTEŽ assays run by ThermoFisher Scientific...


US Patent US10407446 (2019)


BindingDB Entry DOI: 10.7270/Q2MS3W4T
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))
BDBM413448
PNG
(9-((1r,4r)-4-hydroxycyclohexyl)-7-methyl-2-((7-met...)
Show SMILES Cc1cc2ncnn2cc1Nc1ncc2n(C)c(=O)n([C@H]3CC[C@H](O)CC3)c2n1
Show InChI InChI=1S/C19H22N8O2/c1-11-7-16-21-10-22-26(16)9-14(11)23-18-20-8-15-17(24-18)27(19(29)25(15)2)12-3-5-13(28)6-4-12/h7-10,12-13,28H,3-6H2,1-2H3,(H,20,23,24)/t12-,13-
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AstraZeneca AB

US Patent


Assay Description
The inhibitory activity of compounds against AURKA, AURKB, JAK1, JAK2 and JAK3 was determined in Z′-LYTEŽ assays run by ThermoFisher Scientific...


US Patent US10407446 (2019)


BindingDB Entry DOI: 10.7270/Q2MS3W4T
More data for this
Ligand-Target Pair
Aurora kinase B


(Homo sapiens (Human))
BDBM413449
PNG
(9-((1s,4s)-4-hydroxycyclohexyl)-7-methyl-2-((7-met...)
Show SMILES Cc1cc2ncnn2cc1Nc1ncc2n(C)c(=O)n([C@@H]3CC[C@H](O)CC3)c2n1
Show InChI InChI=1S/C19H22N8O2/c1-11-7-16-21-10-22-26(16)9-14(11)23-18-20-8-15-17(24-18)27(19(29)25(15)2)12-3-5-13(28)6-4-12/h7-10,12-13,28H,3-6H2,1-2H3,(H,20,23,24)/t12-,13+
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AstraZeneca AB

US Patent


Assay Description
The inhibitory activity of compounds against AURKA, AURKB, JAK1, JAK2 and JAK3 was determined in Z′-LYTEŽ assays run by ThermoFisher Scientific...


US Patent US10407446 (2019)


BindingDB Entry DOI: 10.7270/Q2MS3W4T
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM413451
PNG
(2-((2,7-dimethyl-[1,2,4]triazolo[1,5-a]pyridin-6-y...)
Show SMILES Cc1nc2cc(C)c(Nc3ncc4n(C)c(=O)n(C5CCOCC5)c4n3)cn2n1
Show InChI InChI=1S/C19H22N8O2/c1-11-8-16-21-12(2)24-26(16)10-14(11)22-18-20-9-15-17(23-18)27(19(28)25(15)3)13-4-6-29-7-5-13/h8-10,13H,4-7H2,1-3H3,(H,20,22,23)
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AstraZeneca AB

US Patent


Assay Description
The inhibitory activity of compounds against AURKA, AURKB, JAK1, JAK2 and JAK3 was determined in Z′-LYTEŽ assays run by ThermoFisher Scientific...


US Patent US10407446 (2019)


BindingDB Entry DOI: 10.7270/Q2MS3W4T
More data for this
Ligand-Target Pair
Aurora kinase A/Targeting protein for Xklp2


(Homo sapiens (Human))
BDBM413451
PNG
(2-((2,7-dimethyl-[1,2,4]triazolo[1,5-a]pyridin-6-y...)
Show SMILES Cc1nc2cc(C)c(Nc3ncc4n(C)c(=O)n(C5CCOCC5)c4n3)cn2n1
Show InChI InChI=1S/C19H22N8O2/c1-11-8-16-21-12(2)24-26(16)10-14(11)22-18-20-9-15-17(23-18)27(19(28)25(15)3)13-4-6-29-7-5-13/h8-10,13H,4-7H2,1-3H3,(H,20,22,23)
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AstraZeneca AB

US Patent


Assay Description
The inhibitory activity of compounds against AURKA, AURKB, JAK1, JAK2 and JAK3 was determined in Z′-LYTEŽ assays run by ThermoFisher Scientific...


US Patent US10407446 (2019)


BindingDB Entry DOI: 10.7270/Q2MS3W4T
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM413453
PNG
(9-((1r,4r)-methoxycyclohexyl)-7-methyl-2-((7-methy...)
Show SMILES CO[C@H]1CC[C@@H](CC1)n1c2nc(Nc3cn4ncnc4cc3C)ncc2n(C)c1=O
Show InChI InChI=1S/C20H24N8O2/c1-12-8-17-22-11-23-27(17)10-15(12)24-19-21-9-16-18(25-19)28(20(29)26(16)2)13-4-6-14(30-3)7-5-13/h8-11,13-14H,4-7H2,1-3H3,(H,21,24,25)/t13-,14-
PDB

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n/an/a<1.00E+4n/an/an/an/an/an/a



AstraZeneca AB

US Patent


Assay Description
The inhibitory activity of compounds against AURKA, AURKB, JAK1, JAK2 and JAK3 was determined in Z′-LYTEŽ assays run by ThermoFisher Scientific...


US Patent US10407446 (2019)


BindingDB Entry DOI: 10.7270/Q2MS3W4T
More data for this
Ligand-Target Pair
Aurora kinase B


(Homo sapiens (Human))
BDBM413457
PNG
(9-((1s,4s)-4-hydroxy-4-methylcyclohexyl)-7-methyl-...)
Show SMILES Cc1cc2ncnn2cc1Nc1ncc2n(C)c(=O)n([C@H]3CC[C@@](C)(O)CC3)c2n1
Show InChI InChI=1S/C20H24N8O2/c1-12-8-16-22-11-23-27(16)10-14(12)24-18-21-9-15-17(25-18)28(19(29)26(15)3)13-4-6-20(2,30)7-5-13/h8-11,13,30H,4-7H2,1-3H3,(H,21,24,25)/t13-,20+
PDB

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UniProtKB/SwissProt

antibodypedia
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US Patent
n/an/a<1.00E+4n/an/an/an/an/an/a



AstraZeneca AB

US Patent


Assay Description
The inhibitory activity of compounds against AURKA, AURKB, JAK1, JAK2 and JAK3 was determined in Z′-LYTEŽ assays run by ThermoFisher Scientific...


US Patent US10407446 (2019)


BindingDB Entry DOI: 10.7270/Q2MS3W4T
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%