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Patent code US10414765

Compile Data Set for Download or QSAR
Found 104 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Potassium channel subfamily K member 9


(Homo sapiens (Human))
BDBM413565
PNG
(US10414765, Example 49)
Show SMILES COc1ccc(C)c(n1)C(=O)N1CC2CN(Cc3c(nc4ccccn34)-c3ccc(Cl)cc3)CC2C1
Show InChI InChI=1S/C28H28ClN5O2/c1-18-6-11-25(36-2)31-26(18)28(35)33-15-20-13-32(14-21(20)16-33)17-23-27(19-7-9-22(29)10-8-19)30-24-5-3-4-12-34(23)24/h3-12,20-21H,13-17H2,1-2H3
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n/an/a 4.60n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
In Vitro Electrophysiological Analysis of the Human TASK-1 and TASK-3 Channels Via Two-Electrode Voltage Clamp Technique in Xenopus laevis OocytesSub...


US Patent US10414765 (2019)


BindingDB Entry DOI: 10.7270/Q2QJ7KNV
More data for this
Ligand-Target Pair
Potassium channel protein TASK-1


(Homo sapiens (Human))
BDBM413514
PNG
(US10414765, Example 17)
Show SMILES COc1cccc(c1)C(=O)N1CC2CN(Cc3c(nc4ccccn34)-c3ccc(Cl)cc3)CC2C1
Show InChI InChI=1S/C28H27ClN4O2/c1-35-24-6-4-5-20(13-24)28(34)32-16-21-14-31(15-22(21)17-32)18-25-27(19-8-10-23(29)11-9-19)30-26-7-2-3-12-33(25)26/h2-13,21-22H,14-18H2,1H3
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n/an/a 9.30n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
In Vitro Electrophysiological Analysis of the Human TASK-1 and TASK-3 Channels Via Two-Electrode Voltage Clamp Technique in Xenopus laevis OocytesSub...


US Patent US10414765 (2019)


BindingDB Entry DOI: 10.7270/Q2QJ7KNV
More data for this
Ligand-Target Pair
Potassium channel subfamily K member 9


(Homo sapiens (Human))
BDBM413514
PNG
(US10414765, Example 17)
Show SMILES COc1cccc(c1)C(=O)N1CC2CN(Cc3c(nc4ccccn34)-c3ccc(Cl)cc3)CC2C1
Show InChI InChI=1S/C28H27ClN4O2/c1-35-24-6-4-5-20(13-24)28(34)32-16-21-14-31(15-22(21)17-32)18-25-27(19-8-10-23(29)11-9-19)30-26-7-2-3-12-33(25)26/h2-13,21-22H,14-18H2,1H3
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n/an/a 21.8n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
In Vitro Electrophysiological Analysis of the Human TASK-1 and TASK-3 Channels Via Two-Electrode Voltage Clamp Technique in Xenopus laevis OocytesSub...


US Patent US10414765 (2019)


BindingDB Entry DOI: 10.7270/Q2QJ7KNV
More data for this
Ligand-Target Pair
Potassium channel protein TASK-1


(Homo sapiens (Human))
BDBM413513
PNG
(US10414765, Example 10)
Show SMILES COc1cccc(c1)C(=O)N1CC2CN(Cc3c(nc4ccccn34)-c3ccc(Br)cc3)CC2C1
Show InChI InChI=1S/C28H27BrN4O2/c1-35-24-6-4-5-20(13-24)28(34)32-16-21-14-31(15-22(21)17-32)18-25-27(19-8-10-23(29)11-9-19)30-26-7-2-3-12-33(25)26/h2-13,21-22H,14-18H2,1H3
PDB

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n/an/a 31.2n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
In Vitro Electrophysiological Analysis of the Human TASK-1 and TASK-3 Channels Via Two-Electrode Voltage Clamp Technique in Xenopus laevis OocytesSub...


US Patent US10414765 (2019)


BindingDB Entry DOI: 10.7270/Q2QJ7KNV
More data for this
Ligand-Target Pair
Potassium channel subfamily K member 9


(Homo sapiens (Human))
BDBM413516
PNG
(US10414765, Example 25)
Show SMILES COc1cccc(n1)C(=O)N1CC2CN(Cc3c(nc4ccccn34)-c3ccc(cc3)C(C)C)CC2C1
Show InChI InChI=1S/C30H33N5O2/c1-20(2)21-10-12-22(13-11-21)29-26(35-14-5-4-8-27(35)32-29)19-33-15-23-17-34(18-24(23)16-33)30(36)25-7-6-9-28(31-25)37-3/h4-14,20,23-24H,15-19H2,1-3H3
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n/an/a 44.1n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
In Vitro Electrophysiological Analysis of the Human TASK-1 and TASK-3 Channels Via Two-Electrode Voltage Clamp Technique in Xenopus laevis OocytesSub...


US Patent US10414765 (2019)


BindingDB Entry DOI: 10.7270/Q2QJ7KNV
More data for this
Ligand-Target Pair
Potassium channel protein TASK-1


(Homo sapiens (Human))
BDBM413512
PNG
(US10414765, Example 4 | [5-{[2-(4-Chlorophenyl)imi...)
Show SMILES COc1cccc(n1)C(=O)N1CC2CN(Cc3c(nc4ccccn34)-c3ccc(Cl)cc3)CC2C1
Show InChI InChI=1S/C27H26ClN5O2/c1-35-25-7-4-5-22(29-25)27(34)32-15-19-13-31(14-20(19)16-32)17-23-26(18-8-10-21(28)11-9-18)30-24-6-2-3-12-33(23)24/h2-12,19-20H,13-17H2,1H3
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n/an/a 59.9n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
In Vitro Electrophysiological Analysis of the Human TASK-1 and TASK-3 Channels Via Two-Electrode Voltage Clamp Technique in Xenopus laevis OocytesSub...


US Patent US10414765 (2019)


BindingDB Entry DOI: 10.7270/Q2QJ7KNV
More data for this
Ligand-Target Pair
Potassium channel protein TASK-1


(Homo sapiens (Human))
BDBM413516
PNG
(US10414765, Example 25)
Show SMILES COc1cccc(n1)C(=O)N1CC2CN(Cc3c(nc4ccccn34)-c3ccc(cc3)C(C)C)CC2C1
Show InChI InChI=1S/C30H33N5O2/c1-20(2)21-10-12-22(13-11-21)29-26(35-14-5-4-8-27(35)32-29)19-33-15-23-17-34(18-24(23)16-33)30(36)25-7-6-9-28(31-25)37-3/h4-14,20,23-24H,15-19H2,1-3H3
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n/an/a 62.2n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
In Vitro Electrophysiological Analysis of the Human TASK-1 and TASK-3 Channels Via Two-Electrode Voltage Clamp Technique in Xenopus laevis OocytesSub...


US Patent US10414765 (2019)


BindingDB Entry DOI: 10.7270/Q2QJ7KNV
More data for this
Ligand-Target Pair
Potassium channel protein TASK-1


(Homo sapiens (Human))
BDBM413564
PNG
(US10414765, Example 48)
Show SMILES COc1ccc(F)c(n1)C(=O)N1CC2CN(Cc3c(nc4ccccn34)-c3ccc(cc3)C(C)C)CC2C1
Show InChI InChI=1S/C30H32FN5O2/c1-19(2)20-7-9-21(10-8-20)28-25(36-13-5-4-6-26(36)32-28)18-34-14-22-16-35(17-23(22)15-34)30(37)29-24(31)11-12-27(33-29)38-3/h4-13,19,22-23H,14-18H2,1-3H3
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n/an/a 78n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
In Vitro Electrophysiological Analysis of the Human TASK-1 and TASK-3 Channels Via Two-Electrode Voltage Clamp Technique in Xenopus laevis OocytesSub...


US Patent US10414765 (2019)


BindingDB Entry DOI: 10.7270/Q2QJ7KNV
More data for this
Ligand-Target Pair
Potassium channel subfamily K member 9


(Homo sapiens (Human))
BDBM413564
PNG
(US10414765, Example 48)
Show SMILES COc1ccc(F)c(n1)C(=O)N1CC2CN(Cc3c(nc4ccccn34)-c3ccc(cc3)C(C)C)CC2C1
Show InChI InChI=1S/C30H32FN5O2/c1-19(2)20-7-9-21(10-8-20)28-25(36-13-5-4-6-26(36)32-28)18-34-14-22-16-35(17-23(22)15-34)30(37)29-24(31)11-12-27(33-29)38-3/h4-13,19,22-23H,14-18H2,1-3H3
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n/an/a 79n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
In Vitro Electrophysiological Analysis of the Human TASK-1 and TASK-3 Channels Via Two-Electrode Voltage Clamp Technique in Xenopus laevis OocytesSub...


US Patent US10414765 (2019)


BindingDB Entry DOI: 10.7270/Q2QJ7KNV
More data for this
Ligand-Target Pair
Potassium channel subfamily K member 9


(Homo sapiens (Human))
BDBM413567
PNG
(US10414765, Example 51)
Show SMILES COc1ccc(Cl)c(n1)C(=O)N1CC2CN(Cc3c(nc4ccccn34)-c3ccc(Cl)cc3)CC2C1
Show InChI InChI=1S/C27H25Cl2N5O2/c1-36-24-10-9-21(29)26(31-24)27(35)33-14-18-12-32(13-19(18)15-33)16-22-25(17-5-7-20(28)8-6-17)30-23-4-2-3-11-34(22)23/h2-11,18-19H,12-16H2,1H3
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n/an/a 80n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
In Vitro Electrophysiological Analysis of the Human TASK-1 and TASK-3 Channels Via Two-Electrode Voltage Clamp Technique in Xenopus laevis OocytesSub...


US Patent US10414765 (2019)


BindingDB Entry DOI: 10.7270/Q2QJ7KNV
More data for this
Ligand-Target Pair
Potassium channel protein TASK-1


(Homo sapiens (Human))
BDBM413565
PNG
(US10414765, Example 49)
Show SMILES COc1ccc(C)c(n1)C(=O)N1CC2CN(Cc3c(nc4ccccn34)-c3ccc(Cl)cc3)CC2C1
Show InChI InChI=1S/C28H28ClN5O2/c1-18-6-11-25(36-2)31-26(18)28(35)33-15-20-13-32(14-21(20)16-33)17-23-27(19-7-9-22(29)10-8-19)30-24-5-3-4-12-34(23)24/h3-12,20-21H,13-17H2,1-2H3
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n/an/a 94n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
In Vitro Electrophysiological Analysis of the Human TASK-1 and TASK-3 Channels Via Two-Electrode Voltage Clamp Technique in Xenopus laevis OocytesSub...


US Patent US10414765 (2019)


BindingDB Entry DOI: 10.7270/Q2QJ7KNV
More data for this
Ligand-Target Pair
Potassium channel subfamily K member 9


(Homo sapiens (Human))
BDBM413542
PNG
(US10414765, Example 23)
Show SMILES FC(F)(F)c1cccc(c1)C(=O)N1CC2CN(Cc3c(nc4ccccn34)-c3ccc(Cl)cc3)CC2C1
Show InChI InChI=1S/C28H24ClF3N4O/c29-23-9-7-18(8-10-23)26-24(36-11-2-1-6-25(36)33-26)17-34-13-20-15-35(16-21(20)14-34)27(37)19-4-3-5-22(12-19)28(30,31)32/h1-12,20-21H,13-17H2
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n/an/a 100n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
In Vitro Electrophysiological Analysis of the Human TASK-1 and TASK-3 Channels Via Two-Electrode Voltage Clamp Technique in Xenopus laevis OocytesSub...


US Patent US10414765 (2019)


BindingDB Entry DOI: 10.7270/Q2QJ7KNV
More data for this
Ligand-Target Pair
Potassium channel subfamily K member 9


(Homo sapiens (Human))
BDBM413566
PNG
(US10414765, Example 50)
Show SMILES COc1ccc(F)c(n1)C(=O)N1CC2CN(Cc3c(nc4ccccn34)-c3ccc(Cl)cc3)CC2C1
Show InChI InChI=1S/C27H25ClFN5O2/c1-36-24-10-9-21(29)26(31-24)27(35)33-14-18-12-32(13-19(18)15-33)16-22-25(17-5-7-20(28)8-6-17)30-23-4-2-3-11-34(22)23/h2-11,18-19H,12-16H2,1H3
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n/an/a 110n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
In Vitro Electrophysiological Analysis of the Human TASK-1 and TASK-3 Channels Via Two-Electrode Voltage Clamp Technique in Xenopus laevis OocytesSub...


US Patent US10414765 (2019)


BindingDB Entry DOI: 10.7270/Q2QJ7KNV
More data for this
Ligand-Target Pair
Potassium channel protein TASK-1


(Homo sapiens (Human))
BDBM413545
PNG
(US10414765, Example 27)
Show SMILES COc1cccc(c1)C(=O)N1CC2CN(Cc3c(nc4ccccn34)-c3ccc(cc3)C(C)C)CC2C1
Show InChI InChI=1S/C31H34N4O2/c1-21(2)22-10-12-23(13-11-22)30-28(35-14-5-4-9-29(35)32-30)20-33-16-25-18-34(19-26(25)17-33)31(36)24-7-6-8-27(15-24)37-3/h4-15,21,25-26H,16-20H2,1-3H3
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n/an/a 170n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
In Vitro Electrophysiological Analysis of the Human TASK-1 and TASK-3 Channels Via Two-Electrode Voltage Clamp Technique in Xenopus laevis OocytesSub...


US Patent US10414765 (2019)


BindingDB Entry DOI: 10.7270/Q2QJ7KNV
More data for this
Ligand-Target Pair
Potassium channel subfamily K member 9


(Homo sapiens (Human))
BDBM413545
PNG
(US10414765, Example 27)
Show SMILES COc1cccc(c1)C(=O)N1CC2CN(Cc3c(nc4ccccn34)-c3ccc(cc3)C(C)C)CC2C1
Show InChI InChI=1S/C31H34N4O2/c1-21(2)22-10-12-23(13-11-22)30-28(35-14-5-4-9-29(35)32-30)20-33-16-25-18-34(19-26(25)17-33)31(36)24-7-6-8-27(15-24)37-3/h4-15,21,25-26H,16-20H2,1-3H3
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n/an/a 170n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
In Vitro Electrophysiological Analysis of the Human TASK-1 and TASK-3 Channels Via Two-Electrode Voltage Clamp Technique in Xenopus laevis OocytesSub...


US Patent US10414765 (2019)


BindingDB Entry DOI: 10.7270/Q2QJ7KNV
More data for this
Ligand-Target Pair
Potassium channel protein TASK-1


(Homo sapiens (Human))
BDBM413554
PNG
(US10414765, Example 36)
Show SMILES FC(F)(F)c1cccc(OC(=O)N2CC3CN(Cc4c(nc5ccccn45)-c4ccc(Br)cc4)CC3C2)c1
Show InChI InChI=1S/C28H24BrF3N4O2/c29-22-9-7-18(8-10-22)26-24(36-11-2-1-6-25(36)33-26)17-34-13-19-15-35(16-20(19)14-34)27(37)38-23-5-3-4-21(12-23)28(30,31)32/h1-12,19-20H,13-17H2
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n/an/a 180n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
In Vitro Electrophysiological Analysis of the Human TASK-1 and TASK-3 Channels Via Two-Electrode Voltage Clamp Technique in Xenopus laevis OocytesSub...


US Patent US10414765 (2019)


BindingDB Entry DOI: 10.7270/Q2QJ7KNV
More data for this
Ligand-Target Pair
Potassium channel subfamily K member 9


(Homo sapiens (Human))
BDBM413546
PNG
(US10414765, Example 28)
Show SMILES CC(C)c1ccc(cc1)-c1nc2ccccn2c1CN1CC2CN(CC2C1)C(=O)C1CCCC1
Show InChI InChI=1S/C29H36N4O/c1-20(2)21-10-12-22(13-11-21)28-26(33-14-6-5-9-27(33)30-28)19-31-15-24-17-32(18-25(24)16-31)29(34)23-7-3-4-8-23/h5-6,9-14,20,23-25H,3-4,7-8,15-19H2,1-2H3
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n/an/a 190n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
In Vitro Electrophysiological Analysis of the Human TASK-1 and TASK-3 Channels Via Two-Electrode Voltage Clamp Technique in Xenopus laevis OocytesSub...


US Patent US10414765 (2019)


BindingDB Entry DOI: 10.7270/Q2QJ7KNV
More data for this
Ligand-Target Pair
Potassium channel protein TASK-1


(Homo sapiens (Human))
BDBM413513
PNG
(US10414765, Example 10)
Show SMILES COc1cccc(c1)C(=O)N1CC2CN(Cc3c(nc4ccccn34)-c3ccc(Br)cc3)CC2C1
Show InChI InChI=1S/C28H27BrN4O2/c1-35-24-6-4-5-20(13-24)28(34)32-16-21-14-31(15-22(21)17-32)18-25-27(19-8-10-23(29)11-9-19)30-26-7-2-3-12-33(25)26/h2-13,21-22H,14-18H2,1H3
PDB

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n/an/a 206n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
In Vitro Electrophysiological Analysis of the Human TASK-1 and TASK-3 Channels Via Two-Electrode Voltage Clamp Technique in Xenopus laevis OocytesSub...


US Patent US10414765 (2019)


BindingDB Entry DOI: 10.7270/Q2QJ7KNV
More data for this
Ligand-Target Pair
Potassium channel protein TASK-1


(Homo sapiens (Human))
BDBM413544
PNG
(US10414765, Example 26)
Show SMILES CC(C)c1ccc(cc1)-c1nc2ccccn2c1CN1CC2CN(CC2C1)C(=O)c1ccccc1F
Show InChI InChI=1S/C30H31FN4O/c1-20(2)21-10-12-22(13-11-21)29-27(35-14-6-5-9-28(35)32-29)19-33-15-23-17-34(18-24(23)16-33)30(36)25-7-3-4-8-26(25)31/h3-14,20,23-24H,15-19H2,1-2H3
PDB

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n/an/a 220n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
In Vitro Electrophysiological Analysis of the Human TASK-1 and TASK-3 Channels Via Two-Electrode Voltage Clamp Technique in Xenopus laevis OocytesSub...


US Patent US10414765 (2019)


BindingDB Entry DOI: 10.7270/Q2QJ7KNV
More data for this
Ligand-Target Pair
Potassium channel protein TASK-1


(Homo sapiens (Human))
BDBM413516
PNG
(US10414765, Example 25)
Show SMILES COc1cccc(n1)C(=O)N1CC2CN(Cc3c(nc4ccccn34)-c3ccc(cc3)C(C)C)CC2C1
Show InChI InChI=1S/C30H33N5O2/c1-20(2)21-10-12-22(13-11-21)29-26(35-14-5-4-8-27(35)32-29)19-33-15-23-17-34(18-24(23)16-33)30(36)25-7-6-9-28(31-25)37-3/h4-14,20,23-24H,15-19H2,1-3H3
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n/an/a 230n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
In Vitro Electrophysiological Analysis of the Human TASK-1 and TASK-3 Channels Via Two-Electrode Voltage Clamp Technique in Xenopus laevis OocytesSub...


US Patent US10414765 (2019)


BindingDB Entry DOI: 10.7270/Q2QJ7KNV
More data for this
Ligand-Target Pair
Potassium channel subfamily K member 9


(Homo sapiens (Human))
BDBM413540
PNG
(US10414765, Example 21)
Show SMILES Cc1ccc(F)cc1C(=O)N1CC2CN(Cc3c(nc4ccccn34)-c3ccc(Cl)cc3)CC2C1
Show InChI InChI=1S/C28H26ClFN4O/c1-18-5-10-23(30)12-24(18)28(35)33-15-20-13-32(14-21(20)16-33)17-25-27(19-6-8-22(29)9-7-19)31-26-4-2-3-11-34(25)26/h2-12,20-21H,13-17H2,1H3
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n/an/a 230n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
In Vitro Electrophysiological Analysis of the Human TASK-1 and TASK-3 Channels Via Two-Electrode Voltage Clamp Technique in Xenopus laevis OocytesSub...


US Patent US10414765 (2019)


BindingDB Entry DOI: 10.7270/Q2QJ7KNV
More data for this
Ligand-Target Pair
Potassium channel subfamily K member 9


(Homo sapiens (Human))
BDBM413563
PNG
(US10414765, Example 47)
Show SMILES Fc1ccc(NC(=O)N2CC3CN(Cc4c(nc5ccccn45)-c4ccc(Br)cc4)CC3C2)cc1
Show InChI InChI=1S/C27H25BrFN5O/c28-21-6-4-18(5-7-21)26-24(34-12-2-1-3-25(34)31-26)17-32-13-19-15-33(16-20(19)14-32)27(35)30-23-10-8-22(29)9-11-23/h1-12,19-20H,13-17H2,(H,30,35)
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n/an/a 240n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
In Vitro Electrophysiological Analysis of the Human TASK-1 and TASK-3 Channels Via Two-Electrode Voltage Clamp Technique in Xenopus laevis OocytesSub...


US Patent US10414765 (2019)


BindingDB Entry DOI: 10.7270/Q2QJ7KNV
More data for this
Ligand-Target Pair
Potassium channel subfamily K member 9


(Homo sapiens (Human))
BDBM413512
PNG
(US10414765, Example 4 | [5-{[2-(4-Chlorophenyl)imi...)
Show SMILES COc1cccc(n1)C(=O)N1CC2CN(Cc3c(nc4ccccn34)-c3ccc(Cl)cc3)CC2C1
Show InChI InChI=1S/C27H26ClN5O2/c1-35-25-7-4-5-22(29-25)27(34)32-15-19-13-31(14-20(19)16-32)17-23-26(18-8-10-21(28)11-9-18)30-24-6-2-3-12-33(23)24/h2-12,19-20H,13-17H2,1H3
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n/an/a 256n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
In Vitro Electrophysiological Analysis of the Human TASK-1 and TASK-3 Channels Via Two-Electrode Voltage Clamp Technique in Xenopus laevis OocytesSub...


US Patent US10414765 (2019)


BindingDB Entry DOI: 10.7270/Q2QJ7KNV
More data for this
Ligand-Target Pair
Potassium channel protein TASK-1


(Homo sapiens (Human))
BDBM413546
PNG
(US10414765, Example 28)
Show SMILES CC(C)c1ccc(cc1)-c1nc2ccccn2c1CN1CC2CN(CC2C1)C(=O)C1CCCC1
Show InChI InChI=1S/C29H36N4O/c1-20(2)21-10-12-22(13-11-21)28-26(33-14-6-5-9-27(33)30-28)19-31-15-24-17-32(18-25(24)16-31)29(34)23-7-3-4-8-23/h5-6,9-14,20,23-25H,3-4,7-8,15-19H2,1-2H3
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n/an/a 300n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
In Vitro Electrophysiological Analysis of the Human TASK-1 and TASK-3 Channels Via Two-Electrode Voltage Clamp Technique in Xenopus laevis OocytesSub...


US Patent US10414765 (2019)


BindingDB Entry DOI: 10.7270/Q2QJ7KNV
More data for this
Ligand-Target Pair
Potassium channel subfamily K member 9


(Homo sapiens (Human))
BDBM413544
PNG
(US10414765, Example 26)
Show SMILES CC(C)c1ccc(cc1)-c1nc2ccccn2c1CN1CC2CN(CC2C1)C(=O)c1ccccc1F
Show InChI InChI=1S/C30H31FN4O/c1-20(2)21-10-12-22(13-11-21)29-27(35-14-6-5-9-28(35)32-29)19-33-15-23-17-34(18-24(23)16-33)30(36)25-7-3-4-8-26(25)31/h3-14,20,23-24H,15-19H2,1-2H3
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n/an/a 310n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
In Vitro Electrophysiological Analysis of the Human TASK-1 and TASK-3 Channels Via Two-Electrode Voltage Clamp Technique in Xenopus laevis OocytesSub...


US Patent US10414765 (2019)


BindingDB Entry DOI: 10.7270/Q2QJ7KNV
More data for this
Ligand-Target Pair
Potassium channel subfamily K member 9


(Homo sapiens (Human))
BDBM413541
PNG
(US10414765, Example 22)
Show SMILES FC(F)(F)Oc1cccc(c1)C(=O)N1CC2CN(Cc3c(nc4ccccn34)-c3ccc(Cl)cc3)CC2C1
Show InChI InChI=1S/C28H24ClF3N4O2/c29-22-9-7-18(8-10-22)26-24(36-11-2-1-6-25(36)33-26)17-34-13-20-15-35(16-21(20)14-34)27(37)19-4-3-5-23(12-19)38-28(30,31)32/h1-12,20-21H,13-17H2
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n/an/a 320n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
In Vitro Electrophysiological Analysis of the Human TASK-1 and TASK-3 Channels Via Two-Electrode Voltage Clamp Technique in Xenopus laevis OocytesSub...


US Patent US10414765 (2019)


BindingDB Entry DOI: 10.7270/Q2QJ7KNV
More data for this
Ligand-Target Pair
Potassium channel protein TASK-1


(Homo sapiens (Human))
BDBM413543
PNG
(US10414765, Example 24)
Show SMILES COc1cccc(n1)C(=O)N1CC2CN(Cc3c(nc4ccccn34)-c3ccc(Br)cc3)CC2C1
Show InChI InChI=1S/C27H26BrN5O2/c1-35-25-7-4-5-22(29-25)27(34)32-15-19-13-31(14-20(19)16-32)17-23-26(18-8-10-21(28)11-9-18)30-24-6-2-3-12-33(23)24/h2-12,19-20H,13-17H2,1H3
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n/an/a 330n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
In Vitro Electrophysiological Analysis of the Human TASK-1 and TASK-3 Channels Via Two-Electrode Voltage Clamp Technique in Xenopus laevis OocytesSub...


US Patent US10414765 (2019)


BindingDB Entry DOI: 10.7270/Q2QJ7KNV
More data for this
Ligand-Target Pair
Potassium channel subfamily K member 9


(Homo sapiens (Human))
BDBM413516
PNG
(US10414765, Example 25)
Show SMILES COc1cccc(n1)C(=O)N1CC2CN(Cc3c(nc4ccccn34)-c3ccc(cc3)C(C)C)CC2C1
Show InChI InChI=1S/C30H33N5O2/c1-20(2)21-10-12-22(13-11-21)29-26(35-14-5-4-8-27(35)32-29)19-33-15-23-17-34(18-24(23)16-33)30(36)25-7-6-9-28(31-25)37-3/h4-14,20,23-24H,15-19H2,1-3H3
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n/an/a 410n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
In Vitro Electrophysiological Analysis of the Human TASK-1 and TASK-3 Channels Via Two-Electrode Voltage Clamp Technique in Xenopus laevis OocytesSub...


US Patent US10414765 (2019)


BindingDB Entry DOI: 10.7270/Q2QJ7KNV
More data for this
Ligand-Target Pair
Potassium channel subfamily K member 9


(Homo sapiens (Human))
BDBM413554
PNG
(US10414765, Example 36)
Show SMILES FC(F)(F)c1cccc(OC(=O)N2CC3CN(Cc4c(nc5ccccn45)-c4ccc(Br)cc4)CC3C2)c1
Show InChI InChI=1S/C28H24BrF3N4O2/c29-22-9-7-18(8-10-22)26-24(36-11-2-1-6-25(36)33-26)17-34-13-19-15-35(16-20(19)14-34)27(37)38-23-5-3-4-21(12-23)28(30,31)32/h1-12,19-20H,13-17H2
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n/an/a 450n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
In Vitro Electrophysiological Analysis of the Human TASK-1 and TASK-3 Channels Via Two-Electrode Voltage Clamp Technique in Xenopus laevis OocytesSub...


US Patent US10414765 (2019)


BindingDB Entry DOI: 10.7270/Q2QJ7KNV
More data for this
Ligand-Target Pair
Potassium channel protein TASK-1


(Homo sapiens (Human))
BDBM413562
PNG
(US10414765, Example 46)
Show SMILES CC(NC(=O)N1CC2CN(Cc3c(nc4ccccn34)-c3ccc(Br)cc3)CC2C1)c1ccccc1
Show InChI InChI=1S/C29H30BrN5O/c1-20(21-7-3-2-4-8-21)31-29(36)34-17-23-15-33(16-24(23)18-34)19-26-28(22-10-12-25(30)13-11-22)32-27-9-5-6-14-35(26)27/h2-14,20,23-24H,15-19H2,1H3,(H,31,36)
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n/an/a 460n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
In Vitro Electrophysiological Analysis of the Human TASK-1 and TASK-3 Channels Via Two-Electrode Voltage Clamp Technique in Xenopus laevis OocytesSub...


US Patent US10414765 (2019)


BindingDB Entry DOI: 10.7270/Q2QJ7KNV
More data for this
Ligand-Target Pair
Potassium channel protein TASK-1


(Homo sapiens (Human))
BDBM413550
PNG
(US10414765, Example 33)
Show SMILES Brc1ccc(cc1)-c1nc2ccccn2c1CN1CC2CN(CC2C1)C(=O)OCc1ccccc1
Show InChI InChI=1S/C28H27BrN4O2/c29-24-11-9-21(10-12-24)27-25(33-13-5-4-8-26(33)30-27)18-31-14-22-16-32(17-23(22)15-31)28(34)35-19-20-6-2-1-3-7-20/h1-13,22-23H,14-19H2
PDB

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n/an/a 460n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
In Vitro Electrophysiological Analysis of the Human TASK-1 and TASK-3 Channels Via Two-Electrode Voltage Clamp Technique in Xenopus laevis OocytesSub...


US Patent US10414765 (2019)


BindingDB Entry DOI: 10.7270/Q2QJ7KNV
More data for this
Ligand-Target Pair
Potassium channel protein TASK-1


(Homo sapiens (Human))
BDBM413548
PNG
(US10414765, Example 30)
Show SMILES Brc1ccc(cc1)-c1nc2ccccn2c1CN1CC2CN(CC2C1)C(=O)N1CCCc2ccccc12
Show InChI InChI=1S/C30H30BrN5O/c31-25-12-10-22(11-13-25)29-27(35-14-4-3-9-28(35)32-29)20-33-16-23-18-34(19-24(23)17-33)30(37)36-15-5-7-21-6-1-2-8-26(21)36/h1-4,6,8-14,23-24H,5,7,15-20H2
PDB

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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
In Vitro Electrophysiological Analysis of the Human TASK-1 and TASK-3 Channels Via Two-Electrode Voltage Clamp Technique in Xenopus laevis OocytesSub...


US Patent US10414765 (2019)


BindingDB Entry DOI: 10.7270/Q2QJ7KNV
More data for this
Ligand-Target Pair
Potassium channel subfamily K member 9


(Homo sapiens (Human))
BDBM413513
PNG
(US10414765, Example 10)
Show SMILES COc1cccc(c1)C(=O)N1CC2CN(Cc3c(nc4ccccn34)-c3ccc(Br)cc3)CC2C1
Show InChI InChI=1S/C28H27BrN4O2/c1-35-24-6-4-5-20(13-24)28(34)32-16-21-14-31(15-22(21)17-32)18-25-27(19-8-10-23(29)11-9-19)30-26-7-2-3-12-33(25)26/h2-13,21-22H,14-18H2,1H3
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
In Vitro Electrophysiological Analysis of the Human TASK-1 and TASK-3 Channels Via Two-Electrode Voltage Clamp Technique in Xenopus laevis OocytesSub...


US Patent US10414765 (2019)


BindingDB Entry DOI: 10.7270/Q2QJ7KNV
More data for this
Ligand-Target Pair
Potassium channel protein TASK-1


(Homo sapiens (Human))
BDBM413551
PNG
(US10414765, Example 34)
Show SMILES Brc1ccc(cc1)-c1nc2ccccn2c1CN1CC2CN(CC2C1)C(=O)OC1CCCC1
Show InChI InChI=1S/C26H29BrN4O2/c27-21-10-8-18(9-11-21)25-23(31-12-4-3-7-24(31)28-25)17-29-13-19-15-30(16-20(19)14-29)26(32)33-22-5-1-2-6-22/h3-4,7-12,19-20,22H,1-2,5-6,13-17H2
PDB

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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
In Vitro Electrophysiological Analysis of the Human TASK-1 and TASK-3 Channels Via Two-Electrode Voltage Clamp Technique in Xenopus laevis OocytesSub...


US Patent US10414765 (2019)


BindingDB Entry DOI: 10.7270/Q2QJ7KNV
More data for this
Ligand-Target Pair
Potassium channel protein TASK-1


(Homo sapiens (Human))
BDBM413557
PNG
(US10414765, Example 41)
Show SMILES Fc1ccccc1NC(=O)N1CC2CN(Cc3c(nc4ccccn34)-c3ccc(Br)cc3)CC2C1
Show InChI InChI=1S/C27H25BrFN5O/c28-21-10-8-18(9-11-21)26-24(34-12-4-3-7-25(34)31-26)17-32-13-19-15-33(16-20(19)14-32)27(35)30-23-6-2-1-5-22(23)29/h1-12,19-20H,13-17H2,(H,30,35)
PDB

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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
In Vitro Electrophysiological Analysis of the Human TASK-1 and TASK-3 Channels Via Two-Electrode Voltage Clamp Technique in Xenopus laevis OocytesSub...


US Patent US10414765 (2019)


BindingDB Entry DOI: 10.7270/Q2QJ7KNV
More data for this
Ligand-Target Pair
Potassium channel protein TASK-1


(Homo sapiens (Human))
BDBM413555
PNG
(US10414765, Example 37)
Show SMILES FCCOC(=O)N1CC2CN(Cc3c(nc4ccccn34)-c3ccc(Br)cc3)CC2C1
Show InChI InChI=1S/C23H24BrFN4O2/c24-19-6-4-16(5-7-19)22-20(29-9-2-1-3-21(29)26-22)15-27-11-17-13-28(14-18(17)12-27)23(30)31-10-8-25/h1-7,9,17-18H,8,10-15H2
PDB

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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
In Vitro Electrophysiological Analysis of the Human TASK-1 and TASK-3 Channels Via Two-Electrode Voltage Clamp Technique in Xenopus laevis OocytesSub...


US Patent US10414765 (2019)


BindingDB Entry DOI: 10.7270/Q2QJ7KNV
More data for this
Ligand-Target Pair
Potassium channel subfamily K member 9


(Homo sapiens (Human))
BDBM413530
PNG
(US10414765, Example 9)
Show SMILES Brc1ccc(cc1)-c1nc2ccccn2c1CN1CC2CN(CC2C1)C(=O)C1CCC1
Show InChI InChI=1S/C25H27BrN4O/c26-21-9-7-17(8-10-21)24-22(30-11-2-1-6-23(30)27-24)16-28-12-19-14-29(15-20(19)13-28)25(31)18-4-3-5-18/h1-2,6-11,18-20H,3-5,12-16H2
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
In Vitro Electrophysiological Analysis of the Human TASK-1 and TASK-3 Channels Via Two-Electrode Voltage Clamp Technique in Xenopus laevis OocytesSub...


US Patent US10414765 (2019)


BindingDB Entry DOI: 10.7270/Q2QJ7KNV
More data for this
Ligand-Target Pair
Potassium channel protein TASK-1


(Homo sapiens (Human))
BDBM413524
PNG
(US10414765, Example 6)
Show SMILES Fc1ccccc1C(=O)N1CC2CN(Cc3c(nc4ccccn34)-c3ccc(Br)cc3)CC2C1
Show InChI InChI=1S/C27H24BrFN4O/c28-21-10-8-18(9-11-21)26-24(33-12-4-3-7-25(33)30-26)17-31-13-19-15-32(16-20(19)14-31)27(34)22-5-1-2-6-23(22)29/h1-12,19-20H,13-17H2
PDB

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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
In Vitro Electrophysiological Analysis of the Human TASK-1 and TASK-3 Channels Via Two-Electrode Voltage Clamp Technique in Xenopus laevis OocytesSub...


US Patent US10414765 (2019)


BindingDB Entry DOI: 10.7270/Q2QJ7KNV
More data for this
Ligand-Target Pair
Potassium channel protein TASK-1


(Homo sapiens (Human))
BDBM413552
PNG
(US10414765, Example 35)
Show SMILES CC(C)OC(=O)N1CC2CN(Cc3c(nc4ccccn34)-c3ccc(Br)cc3)CC2C1
Show InChI InChI=1S/C24H27BrN4O2/c1-16(2)31-24(30)28-13-18-11-27(12-19(18)14-28)15-21-23(17-6-8-20(25)9-7-17)26-22-5-3-4-10-29(21)22/h3-10,16,18-19H,11-15H2,1-2H3
PDB

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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
In Vitro Electrophysiological Analysis of the Human TASK-1 and TASK-3 Channels Via Two-Electrode Voltage Clamp Technique in Xenopus laevis OocytesSub...


US Patent US10414765 (2019)


BindingDB Entry DOI: 10.7270/Q2QJ7KNV
More data for this
Ligand-Target Pair
Potassium channel protein TASK-1


(Homo sapiens (Human))
BDBM413560
PNG
(US10414765, Example 44)
Show SMILES FC(F)(F)c1ccc(Cl)c(NC(=O)N2CC3CN(Cc4c(nc5ccccn45)-c4ccc(Br)cc4)CC3C2)c1
Show InChI InChI=1S/C28H24BrClF3N5O/c29-21-7-4-17(5-8-21)26-24(38-10-2-1-3-25(38)35-26)16-36-12-18-14-37(15-19(18)13-36)27(39)34-23-11-20(28(31,32)33)6-9-22(23)30/h1-11,18-19H,12-16H2,(H,34,39)
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n/an/a 700n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
In Vitro Electrophysiological Analysis of the Human TASK-1 and TASK-3 Channels Via Two-Electrode Voltage Clamp Technique in Xenopus laevis OocytesSub...


US Patent US10414765 (2019)


BindingDB Entry DOI: 10.7270/Q2QJ7KNV
More data for this
Ligand-Target Pair
Potassium channel protein TASK-1


(Homo sapiens (Human))
BDBM413533
PNG
(US10414765, Example 13)
Show SMILES Cc1ccccc1C(=O)N1CC2CN(Cc3c(nc4ccccn34)-c3ccc(Br)cc3)CC2C1
Show InChI InChI=1S/C28H27BrN4O/c1-19-6-2-3-7-24(19)28(34)32-16-21-14-31(15-22(21)17-32)18-25-27(20-9-11-23(29)12-10-20)30-26-8-4-5-13-33(25)26/h2-13,21-22H,14-18H2,1H3
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n/an/a 712n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
In Vitro Electrophysiological Analysis of the Human TASK-1 and TASK-3 Channels Via Two-Electrode Voltage Clamp Technique in Xenopus laevis OocytesSub...


US Patent US10414765 (2019)


BindingDB Entry DOI: 10.7270/Q2QJ7KNV
More data for this
Ligand-Target Pair
Potassium channel protein TASK-1


(Homo sapiens (Human))
BDBM413514
PNG
(US10414765, Example 17)
Show SMILES COc1cccc(c1)C(=O)N1CC2CN(Cc3c(nc4ccccn34)-c3ccc(Cl)cc3)CC2C1
Show InChI InChI=1S/C28H27ClN4O2/c1-35-24-6-4-5-20(13-24)28(34)32-16-21-14-31(15-22(21)17-32)18-25-27(19-8-10-23(29)11-9-19)30-26-7-2-3-12-33(25)26/h2-13,21-22H,14-18H2,1H3
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n/an/a 721n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
In Vitro Electrophysiological Analysis of the Human TASK-1 and TASK-3 Channels Via Two-Electrode Voltage Clamp Technique in Xenopus laevis OocytesSub...


US Patent US10414765 (2019)


BindingDB Entry DOI: 10.7270/Q2QJ7KNV
More data for this
Ligand-Target Pair
Potassium channel protein TASK-1


(Homo sapiens (Human))
BDBM413542
PNG
(US10414765, Example 23)
Show SMILES FC(F)(F)c1cccc(c1)C(=O)N1CC2CN(Cc3c(nc4ccccn34)-c3ccc(Cl)cc3)CC2C1
Show InChI InChI=1S/C28H24ClF3N4O/c29-23-9-7-18(8-10-23)26-24(36-11-2-1-6-25(36)33-26)17-34-13-20-15-35(16-21(20)14-34)27(37)19-4-3-5-22(12-19)28(30,31)32/h1-12,20-21H,13-17H2
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n/an/a 728n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
In Vitro Electrophysiological Analysis of the Human TASK-1 and TASK-3 Channels Via Two-Electrode Voltage Clamp Technique in Xenopus laevis OocytesSub...


US Patent US10414765 (2019)


BindingDB Entry DOI: 10.7270/Q2QJ7KNV
More data for this
Ligand-Target Pair
Potassium channel protein TASK-1


(Homo sapiens (Human))
BDBM413558
PNG
(US10414765, Example 42)
Show SMILES CCOc1ccccc1NC(=O)N1CC2CN(Cc3c(nc4ccccn34)-c3ccc(Br)cc3)CC2C1
Show InChI InChI=1S/C29H30BrN5O2/c1-2-37-26-8-4-3-7-24(26)31-29(36)34-17-21-15-33(16-22(21)18-34)19-25-28(20-10-12-23(30)13-11-20)32-27-9-5-6-14-35(25)27/h3-14,21-22H,2,15-19H2,1H3,(H,31,36)
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n/an/a 740n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
In Vitro Electrophysiological Analysis of the Human TASK-1 and TASK-3 Channels Via Two-Electrode Voltage Clamp Technique in Xenopus laevis OocytesSub...


US Patent US10414765 (2019)


BindingDB Entry DOI: 10.7270/Q2QJ7KNV
More data for this
Ligand-Target Pair
Potassium channel protein TASK-1


(Homo sapiens (Human))
BDBM413530
PNG
(US10414765, Example 9)
Show SMILES Brc1ccc(cc1)-c1nc2ccccn2c1CN1CC2CN(CC2C1)C(=O)C1CCC1
Show InChI InChI=1S/C25H27BrN4O/c26-21-9-7-17(8-10-21)24-22(30-11-2-1-6-23(30)27-24)16-28-12-19-14-29(15-20(19)13-28)25(31)18-4-3-5-18/h1-2,6-11,18-20H,3-5,12-16H2
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n/an/a 749n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
In Vitro Electrophysiological Analysis of the Human TASK-1 and TASK-3 Channels Via Two-Electrode Voltage Clamp Technique in Xenopus laevis OocytesSub...


US Patent US10414765 (2019)


BindingDB Entry DOI: 10.7270/Q2QJ7KNV
More data for this
Ligand-Target Pair
Potassium channel protein TASK-1


(Homo sapiens (Human))
BDBM413525
PNG
(US10414765, Example 7)
Show SMILES Fc1ccc(Cl)c(c1)C(=O)N1CC2CN(Cc3c(nc4ccccn34)-c3ccc(Br)cc3)CC2C1
Show InChI InChI=1S/C27H23BrClFN4O/c28-20-6-4-17(5-7-20)26-24(34-10-2-1-3-25(34)31-26)16-32-12-18-14-33(15-19(18)13-32)27(35)22-11-21(30)8-9-23(22)29/h1-11,18-19H,12-16H2
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n/an/a 787n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
In Vitro Electrophysiological Analysis of the Human TASK-1 and TASK-3 Channels Via Two-Electrode Voltage Clamp Technique in Xenopus laevis OocytesSub...


US Patent US10414765 (2019)


BindingDB Entry DOI: 10.7270/Q2QJ7KNV
More data for this
Ligand-Target Pair
Potassium channel subfamily K member 9


(Homo sapiens (Human))
BDBM413543
PNG
(US10414765, Example 24)
Show SMILES COc1cccc(n1)C(=O)N1CC2CN(Cc3c(nc4ccccn34)-c3ccc(Br)cc3)CC2C1
Show InChI InChI=1S/C27H26BrN5O2/c1-35-25-7-4-5-22(29-25)27(34)32-15-19-13-31(14-20(19)16-32)17-23-26(18-8-10-21(28)11-9-18)30-24-6-2-3-12-33(23)24/h2-12,19-20H,13-17H2,1H3
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n/an/a 800n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
In Vitro Electrophysiological Analysis of the Human TASK-1 and TASK-3 Channels Via Two-Electrode Voltage Clamp Technique in Xenopus laevis OocytesSub...


US Patent US10414765 (2019)


BindingDB Entry DOI: 10.7270/Q2QJ7KNV
More data for this
Ligand-Target Pair
Potassium channel subfamily K member 9


(Homo sapiens (Human))
BDBM413529
PNG
(US10414765, Example 8)
Show SMILES Brc1ccc(cc1)-c1nc2ccccn2c1CN1CC2CN(CC2C1)C(=O)C1CCCCC1
Show InChI InChI=1S/C27H31BrN4O/c28-23-11-9-19(10-12-23)26-24(32-13-5-4-8-25(32)29-26)18-30-14-21-16-31(17-22(21)15-30)27(33)20-6-2-1-3-7-20/h4-5,8-13,20-22H,1-3,6-7,14-18H2
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n/an/a 810n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
In Vitro Electrophysiological Analysis of the Human TASK-1 and TASK-3 Channels Via Two-Electrode Voltage Clamp Technique in Xenopus laevis OocytesSub...


US Patent US10414765 (2019)


BindingDB Entry DOI: 10.7270/Q2QJ7KNV
More data for this
Ligand-Target Pair
Potassium channel protein TASK-1


(Homo sapiens (Human))
BDBM413547
PNG
(5-{[2-(4-Bromophenyl)imidazo[1,2-a]pyridin-3-yl]me...)
Show SMILES CN(C(=O)N1CC2CN(Cc3c(nc4ccccn34)-c3ccc(Br)cc3)CC2C1)c1ccccc1
Show InChI InChI=1S/C28H28BrN5O/c1-31(24-7-3-2-4-8-24)28(35)33-17-21-15-32(16-22(21)18-33)19-25-27(20-10-12-23(29)13-11-20)30-26-9-5-6-14-34(25)26/h2-14,21-22H,15-19H2,1H3
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n/an/a 920n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
In Vitro Electrophysiological Analysis of the Human TASK-1 and TASK-3 Channels Via Two-Electrode Voltage Clamp Technique in Xenopus laevis OocytesSub...


US Patent US10414765 (2019)


BindingDB Entry DOI: 10.7270/Q2QJ7KNV
More data for this
Ligand-Target Pair
Potassium channel protein TASK-1


(Homo sapiens (Human))
BDBM413512
PNG
(US10414765, Example 4 | [5-{[2-(4-Chlorophenyl)imi...)
Show SMILES COc1cccc(n1)C(=O)N1CC2CN(Cc3c(nc4ccccn34)-c3ccc(Cl)cc3)CC2C1
Show InChI InChI=1S/C27H26ClN5O2/c1-35-25-7-4-5-22(29-25)27(34)32-15-19-13-31(14-20(19)16-32)17-23-26(18-8-10-21(28)11-9-18)30-24-6-2-3-12-33(23)24/h2-12,19-20H,13-17H2,1H3
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n/an/a 947n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
In Vitro Electrophysiological Analysis of the Human TASK-1 and TASK-3 Channels Via Two-Electrode Voltage Clamp Technique in Xenopus laevis OocytesSub...


US Patent US10414765 (2019)


BindingDB Entry DOI: 10.7270/Q2QJ7KNV
More data for this
Ligand-Target Pair
Potassium channel subfamily K member 9


(Homo sapiens (Human))
BDBM413532
PNG
(US10414765, Example 12)
Show SMILES COc1ccc(F)cc1C(=O)N1CC2CN(Cc3c(nc4ccccn34)-c3ccc(Br)cc3)CC2C1
Show InChI InChI=1S/C28H26BrFN4O2/c1-36-25-10-9-22(30)12-23(25)28(35)33-15-19-13-32(14-20(19)16-33)17-24-27(18-5-7-21(29)8-6-18)31-26-4-2-3-11-34(24)26/h2-12,19-20H,13-17H2,1H3
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n/an/a 960n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
In Vitro Electrophysiological Analysis of the Human TASK-1 and TASK-3 Channels Via Two-Electrode Voltage Clamp Technique in Xenopus laevis OocytesSub...


US Patent US10414765 (2019)


BindingDB Entry DOI: 10.7270/Q2QJ7KNV
More data for this
Ligand-Target Pair
Potassium channel subfamily K member 9


(Homo sapiens (Human))
BDBM413513
PNG
(US10414765, Example 10)
Show SMILES COc1cccc(c1)C(=O)N1CC2CN(Cc3c(nc4ccccn34)-c3ccc(Br)cc3)CC2C1
Show InChI InChI=1S/C28H27BrN4O2/c1-35-24-6-4-5-20(13-24)28(34)32-16-21-14-31(15-22(21)17-32)18-25-27(19-8-10-23(29)11-9-19)30-26-7-2-3-12-33(25)26/h2-13,21-22H,14-18H2,1H3
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n/an/a 970n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
In Vitro Electrophysiological Analysis of the Human TASK-1 and TASK-3 Channels Via Two-Electrode Voltage Clamp Technique in Xenopus laevis OocytesSub...


US Patent US10414765 (2019)


BindingDB Entry DOI: 10.7270/Q2QJ7KNV
More data for this
Ligand-Target Pair
Potassium channel protein TASK-1


(Homo sapiens (Human))
BDBM413535
PNG
(US10414765, Example 15)
Show SMILES Fc1ccc(Cl)c(c1)C(=O)N1CC2CN(Cc3c(nc4ccccn34)-c3ccc(Cl)cc3)CC2C1
Show InChI InChI=1S/C27H23Cl2FN4O/c28-20-6-4-17(5-7-20)26-24(34-10-2-1-3-25(34)31-26)16-32-12-18-14-33(15-19(18)13-32)27(35)22-11-21(30)8-9-23(22)29/h1-11,18-19H,12-16H2
PDB

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n/an/a 1.00E+3n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
In Vitro Electrophysiological Analysis of the Human TASK-1 and TASK-3 Channels Via Two-Electrode Voltage Clamp Technique in Xenopus laevis OocytesSub...


US Patent US10414765 (2019)


BindingDB Entry DOI: 10.7270/Q2QJ7KNV
More data for this
Ligand-Target Pair
Potassium channel protein TASK-1


(Homo sapiens (Human))
BDBM413563
PNG
(US10414765, Example 47)
Show SMILES Fc1ccc(NC(=O)N2CC3CN(Cc4c(nc5ccccn45)-c4ccc(Br)cc4)CC3C2)cc1
Show InChI InChI=1S/C27H25BrFN5O/c28-21-6-4-18(5-7-21)26-24(34-12-2-1-3-25(34)31-26)17-32-13-19-15-33(16-20(19)14-32)27(35)30-23-10-8-22(29)9-11-23/h1-12,19-20H,13-17H2,(H,30,35)
PDB

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n/an/a 1.00E+3n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
In Vitro Electrophysiological Analysis of the Human TASK-1 and TASK-3 Channels Via Two-Electrode Voltage Clamp Technique in Xenopus laevis OocytesSub...


US Patent US10414765 (2019)


BindingDB Entry DOI: 10.7270/Q2QJ7KNV
More data for this
Ligand-Target Pair
Potassium channel protein TASK-1


(Homo sapiens (Human))
BDBM413539
PNG
(US10414765, Example 20)
Show SMILES Cc1ccccc1C(=O)N1CC2CN(Cc3c(nc4ccccn34)-c3ccc(Cl)cc3)CC2C1
Show InChI InChI=1S/C28H27ClN4O/c1-19-6-2-3-7-24(19)28(34)32-16-21-14-31(15-22(21)17-32)18-25-27(20-9-11-23(29)12-10-20)30-26-8-4-5-13-33(25)26/h2-13,21-22H,14-18H2,1H3
PDB

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n/an/a 1.02E+3n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
In Vitro Electrophysiological Analysis of the Human TASK-1 and TASK-3 Channels Via Two-Electrode Voltage Clamp Technique in Xenopus laevis OocytesSub...


US Patent US10414765 (2019)


BindingDB Entry DOI: 10.7270/Q2QJ7KNV
More data for this
Ligand-Target Pair
Potassium channel protein TASK-1


(Homo sapiens (Human))
BDBM413534
PNG
(US10414765, Example 14)
Show SMILES Fc1ccccc1C(=O)N1CC2CN(Cc3c(nc4ccccn34)-c3ccc(Cl)cc3)CC2C1
Show InChI InChI=1S/C27H24ClFN4O/c28-21-10-8-18(9-11-21)26-24(33-12-4-3-7-25(33)30-26)17-31-13-19-15-32(16-20(19)14-31)27(34)22-5-1-2-6-23(22)29/h1-12,19-20H,13-17H2
PDB

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n/an/a 1.06E+3n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
In Vitro Electrophysiological Analysis of the Human TASK-1 and TASK-3 Channels Via Two-Electrode Voltage Clamp Technique in Xenopus laevis OocytesSub...


US Patent US10414765 (2019)


BindingDB Entry DOI: 10.7270/Q2QJ7KNV
More data for this
Ligand-Target Pair
Potassium channel subfamily K member 9


(Homo sapiens (Human))
BDBM413536
PNG
(US10414765, Example 16)
Show SMILES Clc1ccc(cc1)-c1nc2ccccn2c1CN1CC2CN(CC2C1)C(=O)C1CCCCC1
Show InChI InChI=1S/C27H31ClN4O/c28-23-11-9-19(10-12-23)26-24(32-13-5-4-8-25(32)29-26)18-30-14-21-16-31(17-22(21)15-30)27(33)20-6-2-1-3-7-20/h4-5,8-13,20-22H,1-3,6-7,14-18H2
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n/an/a 1.10E+3n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
In Vitro Electrophysiological Analysis of the Human TASK-1 and TASK-3 Channels Via Two-Electrode Voltage Clamp Technique in Xenopus laevis OocytesSub...


US Patent US10414765 (2019)


BindingDB Entry DOI: 10.7270/Q2QJ7KNV
More data for this
Ligand-Target Pair
Potassium channel protein TASK-1


(Homo sapiens (Human))
BDBM413549
PNG
(US10414765, Example 32)
Show SMILES CC(C)COC(=O)N1CC2CN(Cc3c(nc4ccccn34)-c3ccc(Br)cc3)CC2C1
Show InChI InChI=1S/C25H29BrN4O2/c1-17(2)16-32-25(31)29-13-19-11-28(12-20(19)14-29)15-22-24(18-6-8-21(26)9-7-18)27-23-5-3-4-10-30(22)23/h3-10,17,19-20H,11-16H2,1-2H3
PDB

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n/an/a 1.10E+3n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
In Vitro Electrophysiological Analysis of the Human TASK-1 and TASK-3 Channels Via Two-Electrode Voltage Clamp Technique in Xenopus laevis OocytesSub...


US Patent US10414765 (2019)


BindingDB Entry DOI: 10.7270/Q2QJ7KNV
More data for this
Ligand-Target Pair
Potassium channel protein TASK-1


(Homo sapiens (Human))
BDBM413566
PNG
(US10414765, Example 50)
Show SMILES COc1ccc(F)c(n1)C(=O)N1CC2CN(Cc3c(nc4ccccn34)-c3ccc(Cl)cc3)CC2C1
Show InChI InChI=1S/C27H25ClFN5O2/c1-36-24-10-9-21(29)26(31-24)27(35)33-14-18-12-32(13-19(18)15-33)16-22-25(17-5-7-20(28)8-6-17)30-23-4-2-3-11-34(22)23/h2-11,18-19H,12-16H2,1H3
PDB

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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
In Vitro Electrophysiological Analysis of the Human TASK-1 and TASK-3 Channels Via Two-Electrode Voltage Clamp Technique in Xenopus laevis OocytesSub...


US Patent US10414765 (2019)


BindingDB Entry DOI: 10.7270/Q2QJ7KNV
More data for this
Ligand-Target Pair
Potassium channel protein TASK-1


(Homo sapiens (Human))
BDBM413522
PNG
(US10414765, Example 5 | [5-{[2-(4-Bromophenyl)imid...)
Show SMILES Brc1ccc(cc1)-c1nc2ccccn2c1CN1CC2CN(CC2C1)C(=O)C1CCCC1
Show InChI InChI=1S/C26H29BrN4O/c27-22-10-8-18(9-11-22)25-23(31-12-4-3-7-24(31)28-25)17-29-13-20-15-30(16-21(20)14-29)26(32)19-5-1-2-6-19/h3-4,7-12,19-21H,1-2,5-6,13-17H2
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n/an/a 1.13E+3n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
In Vitro Electrophysiological Analysis of the Human TASK-1 and TASK-3 Channels Via Two-Electrode Voltage Clamp Technique in Xenopus laevis OocytesSub...


US Patent US10414765 (2019)


BindingDB Entry DOI: 10.7270/Q2QJ7KNV
More data for this
Ligand-Target Pair
Potassium channel subfamily K member 9


(Homo sapiens (Human))
BDBM413549
PNG
(US10414765, Example 32)
Show SMILES CC(C)COC(=O)N1CC2CN(Cc3c(nc4ccccn34)-c3ccc(Br)cc3)CC2C1
Show InChI InChI=1S/C25H29BrN4O2/c1-17(2)16-32-25(31)29-13-19-11-28(12-20(19)14-29)15-22-24(18-6-8-21(26)9-7-18)27-23-5-3-4-10-30(22)23/h3-10,17,19-20H,11-16H2,1-2H3
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n/an/a 1.20E+3n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
In Vitro Electrophysiological Analysis of the Human TASK-1 and TASK-3 Channels Via Two-Electrode Voltage Clamp Technique in Xenopus laevis OocytesSub...


US Patent US10414765 (2019)


BindingDB Entry DOI: 10.7270/Q2QJ7KNV
More data for this
Ligand-Target Pair
Potassium channel subfamily K member 9


(Homo sapiens (Human))
BDBM413548
PNG
(US10414765, Example 30)
Show SMILES Brc1ccc(cc1)-c1nc2ccccn2c1CN1CC2CN(CC2C1)C(=O)N1CCCc2ccccc12
Show InChI InChI=1S/C30H30BrN5O/c31-25-12-10-22(11-13-25)29-27(35-14-4-3-9-28(35)32-29)20-33-16-23-18-34(19-24(23)17-33)30(37)36-15-5-7-21-6-1-2-8-26(21)36/h1-4,6,8-14,23-24H,5,7,15-20H2
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
In Vitro Electrophysiological Analysis of the Human TASK-1 and TASK-3 Channels Via Two-Electrode Voltage Clamp Technique in Xenopus laevis OocytesSub...


US Patent US10414765 (2019)


BindingDB Entry DOI: 10.7270/Q2QJ7KNV
More data for this
Ligand-Target Pair
Potassium channel protein TASK-1


(Homo sapiens (Human))
BDBM413532
PNG
(US10414765, Example 12)
Show SMILES COc1ccc(F)cc1C(=O)N1CC2CN(Cc3c(nc4ccccn34)-c3ccc(Br)cc3)CC2C1
Show InChI InChI=1S/C28H26BrFN4O2/c1-36-25-10-9-22(30)12-23(25)28(35)33-15-19-13-32(14-20(19)16-33)17-24-27(18-5-7-21(29)8-6-18)31-26-4-2-3-11-34(24)26/h2-12,19-20H,13-17H2,1H3
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n/an/a 1.20E+3n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
In Vitro Electrophysiological Analysis of the Human TASK-1 and TASK-3 Channels Via Two-Electrode Voltage Clamp Technique in Xenopus laevis OocytesSub...


US Patent US10414765 (2019)


BindingDB Entry DOI: 10.7270/Q2QJ7KNV
More data for this
Ligand-Target Pair
Potassium channel protein TASK-1


(Homo sapiens (Human))
BDBM413531
PNG
(US10414765, Example 11)
Show SMILES COc1ccccc1C(=O)N1CC2CN(Cc3c(nc4ccccn34)-c3ccc(Br)cc3)CC2C1
Show InChI InChI=1S/C28H27BrN4O2/c1-35-25-7-3-2-6-23(25)28(34)32-16-20-14-31(15-21(20)17-32)18-24-27(19-9-11-22(29)12-10-19)30-26-8-4-5-13-33(24)26/h2-13,20-21H,14-18H2,1H3
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n/an/a 1.21E+3n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
In Vitro Electrophysiological Analysis of the Human TASK-1 and TASK-3 Channels Via Two-Electrode Voltage Clamp Technique in Xenopus laevis OocytesSub...


US Patent US10414765 (2019)


BindingDB Entry DOI: 10.7270/Q2QJ7KNV
More data for this
Ligand-Target Pair
Potassium channel protein TASK-1


(Homo sapiens (Human))
BDBM413538
PNG
(US10414765, Example 19)
Show SMILES COc1ccc(F)cc1C(=O)N1CC2CN(Cc3c(nc4ccccn34)-c3ccc(Cl)cc3)CC2C1
Show InChI InChI=1S/C28H26ClFN4O2/c1-36-25-10-9-22(30)12-23(25)28(35)33-15-19-13-32(14-20(19)16-33)17-24-27(18-5-7-21(29)8-6-18)31-26-4-2-3-11-34(24)26/h2-12,19-20H,13-17H2,1H3
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
In Vitro Electrophysiological Analysis of the Human TASK-1 and TASK-3 Channels Via Two-Electrode Voltage Clamp Technique in Xenopus laevis OocytesSub...


US Patent US10414765 (2019)


BindingDB Entry DOI: 10.7270/Q2QJ7KNV
More data for this
Ligand-Target Pair
Potassium channel protein TASK-1


(Homo sapiens (Human))
BDBM413540
PNG
(US10414765, Example 21)
Show SMILES Cc1ccc(F)cc1C(=O)N1CC2CN(Cc3c(nc4ccccn34)-c3ccc(Cl)cc3)CC2C1
Show InChI InChI=1S/C28H26ClFN4O/c1-18-5-10-23(30)12-24(18)28(35)33-15-20-13-32(14-21(20)16-33)17-25-27(19-6-8-22(29)9-7-19)31-26-4-2-3-11-34(25)26/h2-12,20-21H,13-17H2,1H3
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
In Vitro Electrophysiological Analysis of the Human TASK-1 and TASK-3 Channels Via Two-Electrode Voltage Clamp Technique in Xenopus laevis OocytesSub...


US Patent US10414765 (2019)


BindingDB Entry DOI: 10.7270/Q2QJ7KNV
More data for this
Ligand-Target Pair
Potassium channel subfamily K member 9


(Homo sapiens (Human))
BDBM413533
PNG
(US10414765, Example 13)
Show SMILES Cc1ccccc1C(=O)N1CC2CN(Cc3c(nc4ccccn34)-c3ccc(Br)cc3)CC2C1
Show InChI InChI=1S/C28H27BrN4O/c1-19-6-2-3-7-24(19)28(34)32-16-21-14-31(15-22(21)17-32)18-25-27(20-9-11-23(29)12-10-20)30-26-8-4-5-13-33(25)26/h2-13,21-22H,14-18H2,1H3
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n/an/a 1.30E+3n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
In Vitro Electrophysiological Analysis of the Human TASK-1 and TASK-3 Channels Via Two-Electrode Voltage Clamp Technique in Xenopus laevis OocytesSub...


US Patent US10414765 (2019)


BindingDB Entry DOI: 10.7270/Q2QJ7KNV
More data for this
Ligand-Target Pair
Potassium channel subfamily K member 9


(Homo sapiens (Human))
BDBM413524
PNG
(US10414765, Example 6)
Show SMILES Fc1ccccc1C(=O)N1CC2CN(Cc3c(nc4ccccn34)-c3ccc(Br)cc3)CC2C1
Show InChI InChI=1S/C27H24BrFN4O/c28-21-10-8-18(9-11-21)26-24(33-12-4-3-7-25(33)30-26)17-31-13-19-15-32(16-20(19)14-31)27(34)22-5-1-2-6-23(22)29/h1-12,19-20H,13-17H2
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
In Vitro Electrophysiological Analysis of the Human TASK-1 and TASK-3 Channels Via Two-Electrode Voltage Clamp Technique in Xenopus laevis OocytesSub...


US Patent US10414765 (2019)


BindingDB Entry DOI: 10.7270/Q2QJ7KNV
More data for this
Ligand-Target Pair
Potassium channel protein TASK-1


(Homo sapiens (Human))
BDBM413529
PNG
(US10414765, Example 8)
Show SMILES Brc1ccc(cc1)-c1nc2ccccn2c1CN1CC2CN(CC2C1)C(=O)C1CCCCC1
Show InChI InChI=1S/C27H31BrN4O/c28-23-11-9-19(10-12-23)26-24(32-13-5-4-8-25(32)29-26)18-30-14-21-16-31(17-22(21)15-30)27(33)20-6-2-1-3-7-20/h4-5,8-13,20-22H,1-3,6-7,14-18H2
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n/an/a 1.36E+3n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
In Vitro Electrophysiological Analysis of the Human TASK-1 and TASK-3 Channels Via Two-Electrode Voltage Clamp Technique in Xenopus laevis OocytesSub...


US Patent US10414765 (2019)


BindingDB Entry DOI: 10.7270/Q2QJ7KNV
More data for this
Ligand-Target Pair
Potassium channel protein TASK-1


(Homo sapiens (Human))
BDBM413567
PNG
(US10414765, Example 51)
Show SMILES COc1ccc(Cl)c(n1)C(=O)N1CC2CN(Cc3c(nc4ccccn34)-c3ccc(Cl)cc3)CC2C1
Show InChI InChI=1S/C27H25Cl2N5O2/c1-36-24-10-9-21(29)26(31-24)27(35)33-14-18-12-32(13-19(18)15-33)16-22-25(17-5-7-20(28)8-6-17)30-23-4-2-3-11-34(22)23/h2-11,18-19H,12-16H2,1H3
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n/an/a 1.40E+3n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
In Vitro Electrophysiological Analysis of the Human TASK-1 and TASK-3 Channels Via Two-Electrode Voltage Clamp Technique in Xenopus laevis OocytesSub...


US Patent US10414765 (2019)


BindingDB Entry DOI: 10.7270/Q2QJ7KNV
More data for this
Ligand-Target Pair
Potassium channel protein TASK-1


(Homo sapiens (Human))
BDBM413541
PNG
(US10414765, Example 22)
Show SMILES FC(F)(F)Oc1cccc(c1)C(=O)N1CC2CN(Cc3c(nc4ccccn34)-c3ccc(Cl)cc3)CC2C1
Show InChI InChI=1S/C28H24ClF3N4O2/c29-22-9-7-18(8-10-22)26-24(36-11-2-1-6-25(36)33-26)17-34-13-20-15-35(16-21(20)14-34)27(37)19-4-3-5-23(12-19)38-28(30,31)32/h1-12,20-21H,13-17H2
PDB

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n/an/a 1.46E+3n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
In Vitro Electrophysiological Analysis of the Human TASK-1 and TASK-3 Channels Via Two-Electrode Voltage Clamp Technique in Xenopus laevis OocytesSub...


US Patent US10414765 (2019)


BindingDB Entry DOI: 10.7270/Q2QJ7KNV
More data for this
Ligand-Target Pair
Potassium channel subfamily K member 9


(Homo sapiens (Human))
BDBM413538
PNG
(US10414765, Example 19)
Show SMILES COc1ccc(F)cc1C(=O)N1CC2CN(Cc3c(nc4ccccn34)-c3ccc(Cl)cc3)CC2C1
Show InChI InChI=1S/C28H26ClFN4O2/c1-36-25-10-9-22(30)12-23(25)28(35)33-15-19-13-32(14-20(19)16-33)17-24-27(18-5-7-21(29)8-6-18)31-26-4-2-3-11-34(24)26/h2-12,19-20H,13-17H2,1H3
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
In Vitro Electrophysiological Analysis of the Human TASK-1 and TASK-3 Channels Via Two-Electrode Voltage Clamp Technique in Xenopus laevis OocytesSub...


US Patent US10414765 (2019)


BindingDB Entry DOI: 10.7270/Q2QJ7KNV
More data for this
Ligand-Target Pair
Potassium channel protein TASK-1


(Homo sapiens (Human))
BDBM413556
PNG
(5-{[2-(4-Bromophenyl)imidazo[1,2-a]pyridin-3-yl]me...)
Show SMILES Fc1ccc(NC(=O)N2CC3CN(Cc4c(nc5ccccn45)-c4ccc(Br)cc4)CC3C2)c(F)c1
Show InChI InChI=1S/C27H24BrF2N5O/c28-20-6-4-17(5-7-20)26-24(35-10-2-1-3-25(35)32-26)16-33-12-18-14-34(15-19(18)13-33)27(36)31-23-9-8-21(29)11-22(23)30/h1-11,18-19H,12-16H2,(H,31,36)
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n/an/a 1.50E+3n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
In Vitro Electrophysiological Analysis of the Human TASK-1 and TASK-3 Channels Via Two-Electrode Voltage Clamp Technique in Xenopus laevis OocytesSub...


US Patent US10414765 (2019)


BindingDB Entry DOI: 10.7270/Q2QJ7KNV
More data for this
Ligand-Target Pair
Potassium channel subfamily K member 9


(Homo sapiens (Human))
BDBM413522
PNG
(US10414765, Example 5 | [5-{[2-(4-Bromophenyl)imid...)
Show SMILES Brc1ccc(cc1)-c1nc2ccccn2c1CN1CC2CN(CC2C1)C(=O)C1CCCC1
Show InChI InChI=1S/C26H29BrN4O/c27-22-10-8-18(9-11-22)25-23(31-12-4-3-7-24(31)28-25)17-29-13-20-15-30(16-21(20)14-29)26(32)19-5-1-2-6-19/h3-4,7-12,19-21H,1-2,5-6,13-17H2
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n/an/a 1.60E+3n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
In Vitro Electrophysiological Analysis of the Human TASK-1 and TASK-3 Channels Via Two-Electrode Voltage Clamp Technique in Xenopus laevis OocytesSub...


US Patent US10414765 (2019)


BindingDB Entry DOI: 10.7270/Q2QJ7KNV
More data for this
Ligand-Target Pair
Potassium channel protein TASK-1


(Homo sapiens (Human))
BDBM413537
PNG
(US10414765, Example 18)
Show SMILES COc1ccccc1C(=O)N1CC2CN(Cc3c(nc4ccccn34)-c3ccc(Cl)cc3)CC2C1
Show InChI InChI=1S/C28H27ClN4O2/c1-35-25-7-3-2-6-23(25)28(34)32-16-20-14-31(15-21(20)17-32)18-24-27(19-9-11-22(29)12-10-19)30-26-8-4-5-13-33(24)26/h2-13,20-21H,14-18H2,1H3
PDB

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n/an/a 1.68E+3n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
In Vitro Electrophysiological Analysis of the Human TASK-1 and TASK-3 Channels Via Two-Electrode Voltage Clamp Technique in Xenopus laevis OocytesSub...


US Patent US10414765 (2019)


BindingDB Entry DOI: 10.7270/Q2QJ7KNV
More data for this
Ligand-Target Pair
Potassium channel protein TASK-1


(Homo sapiens (Human))
BDBM413559
PNG
(US10414765, Example 43)
Show SMILES FC(F)(F)c1cc(NC(=O)N2CC3CN(Cc4c(nc5ccccn45)-c4ccc(Br)cc4)CC3C2)ccc1Cl
Show InChI InChI=1S/C28H24BrClF3N5O/c29-20-6-4-17(5-7-20)26-24(38-10-2-1-3-25(38)35-26)16-36-12-18-14-37(15-19(18)13-36)27(39)34-21-8-9-23(30)22(11-21)28(31,32)33/h1-11,18-19H,12-16H2,(H,34,39)
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n/an/a 1.70E+3n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
In Vitro Electrophysiological Analysis of the Human TASK-1 and TASK-3 Channels Via Two-Electrode Voltage Clamp Technique in Xenopus laevis OocytesSub...


US Patent US10414765 (2019)


BindingDB Entry DOI: 10.7270/Q2QJ7KNV
More data for this
Ligand-Target Pair
Potassium channel subfamily K member 9


(Homo sapiens (Human))
BDBM413552
PNG
(US10414765, Example 35)
Show SMILES CC(C)OC(=O)N1CC2CN(Cc3c(nc4ccccn34)-c3ccc(Br)cc3)CC2C1
Show InChI InChI=1S/C24H27BrN4O2/c1-16(2)31-24(30)28-13-18-11-27(12-19(18)14-28)15-21-23(17-6-8-20(25)9-7-17)26-22-5-3-4-10-29(21)22/h3-10,16,18-19H,11-15H2,1-2H3
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n/an/a 1.70E+3n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
In Vitro Electrophysiological Analysis of the Human TASK-1 and TASK-3 Channels Via Two-Electrode Voltage Clamp Technique in Xenopus laevis OocytesSub...


US Patent US10414765 (2019)


BindingDB Entry DOI: 10.7270/Q2QJ7KNV
More data for this
Ligand-Target Pair
Potassium channel protein TASK-1


(Homo sapiens (Human))
BDBM413519
PNG
(US10414765, Example 2)
Show SMILES CC(C)(C)OC(=O)N1CC2CN(Cc3c(nc4ccccn34)-c3ccc(Br)cc3)CC2C1
Show InChI InChI=1S/C25H29BrN4O2/c1-25(2,3)32-24(31)29-14-18-12-28(13-19(18)15-29)16-21-23(17-7-9-20(26)10-8-17)27-22-6-4-5-11-30(21)22/h4-11,18-19H,12-16H2,1-3H3
PDB

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n/an/a 1.73E+3n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
In Vitro Electrophysiological Analysis of the Human TASK-1 and TASK-3 Channels Via Two-Electrode Voltage Clamp Technique in Xenopus laevis OocytesSub...


US Patent US10414765 (2019)


BindingDB Entry DOI: 10.7270/Q2QJ7KNV
More data for this
Ligand-Target Pair
Potassium channel subfamily K member 9


(Homo sapiens (Human))
BDBM413555
PNG
(US10414765, Example 37)
Show SMILES FCCOC(=O)N1CC2CN(Cc3c(nc4ccccn34)-c3ccc(Br)cc3)CC2C1
Show InChI InChI=1S/C23H24BrFN4O2/c24-19-6-4-16(5-7-19)22-20(29-9-2-1-3-21(29)26-22)15-27-11-17-13-28(14-18(17)12-27)23(30)31-10-8-25/h1-7,9,17-18H,8,10-15H2
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n/an/a 1.80E+3n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
In Vitro Electrophysiological Analysis of the Human TASK-1 and TASK-3 Channels Via Two-Electrode Voltage Clamp Technique in Xenopus laevis OocytesSub...


US Patent US10414765 (2019)


BindingDB Entry DOI: 10.7270/Q2QJ7KNV
More data for this
Ligand-Target Pair
Potassium channel subfamily K member 9


(Homo sapiens (Human))
BDBM413556
PNG
(5-{[2-(4-Bromophenyl)imidazo[1,2-a]pyridin-3-yl]me...)
Show SMILES Fc1ccc(NC(=O)N2CC3CN(Cc4c(nc5ccccn45)-c4ccc(Br)cc4)CC3C2)c(F)c1
Show InChI InChI=1S/C27H24BrF2N5O/c28-20-6-4-17(5-7-20)26-24(35-10-2-1-3-25(35)32-26)16-33-12-18-14-34(15-19(18)13-33)27(36)31-23-9-8-21(29)11-22(23)30/h1-11,18-19H,12-16H2,(H,31,36)
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n/an/a 1.90E+3n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
In Vitro Electrophysiological Analysis of the Human TASK-1 and TASK-3 Channels Via Two-Electrode Voltage Clamp Technique in Xenopus laevis OocytesSub...


US Patent US10414765 (2019)


BindingDB Entry DOI: 10.7270/Q2QJ7KNV
More data for this
Ligand-Target Pair
Potassium channel subfamily K member 9


(Homo sapiens (Human))
BDBM413514
PNG
(US10414765, Example 17)
Show SMILES COc1cccc(c1)C(=O)N1CC2CN(Cc3c(nc4ccccn34)-c3ccc(Cl)cc3)CC2C1
Show InChI InChI=1S/C28H27ClN4O2/c1-35-24-6-4-5-20(13-24)28(34)32-16-21-14-31(15-22(21)17-32)18-25-27(19-8-10-23(29)11-9-19)30-26-7-2-3-12-33(25)26/h2-13,21-22H,14-18H2,1H3
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n/an/a 1.90E+3n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
In Vitro Electrophysiological Analysis of the Human TASK-1 and TASK-3 Channels Via Two-Electrode Voltage Clamp Technique in Xenopus laevis OocytesSub...


US Patent US10414765 (2019)


BindingDB Entry DOI: 10.7270/Q2QJ7KNV
More data for this
Ligand-Target Pair
Potassium channel protein TASK-1


(Homo sapiens (Human))
BDBM413536
PNG
(US10414765, Example 16)
Show SMILES Clc1ccc(cc1)-c1nc2ccccn2c1CN1CC2CN(CC2C1)C(=O)C1CCCCC1
Show InChI InChI=1S/C27H31ClN4O/c28-23-11-9-19(10-12-23)26-24(32-13-5-4-8-25(32)29-26)18-30-14-21-16-31(17-22(21)15-30)27(33)20-6-2-1-3-7-20/h4-5,8-13,20-22H,1-3,6-7,14-18H2
PDB

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n/an/a 1.94E+3n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
In Vitro Electrophysiological Analysis of the Human TASK-1 and TASK-3 Channels Via Two-Electrode Voltage Clamp Technique in Xenopus laevis OocytesSub...


US Patent US10414765 (2019)


BindingDB Entry DOI: 10.7270/Q2QJ7KNV
More data for this
Ligand-Target Pair
Potassium channel subfamily K member 9


(Homo sapiens (Human))
BDBM413559
PNG
(US10414765, Example 43)
Show SMILES FC(F)(F)c1cc(NC(=O)N2CC3CN(Cc4c(nc5ccccn45)-c4ccc(Br)cc4)CC3C2)ccc1Cl
Show InChI InChI=1S/C28H24BrClF3N5O/c29-20-6-4-17(5-7-20)26-24(38-10-2-1-3-25(38)35-26)16-36-12-18-14-37(15-19(18)13-36)27(39)34-21-8-9-23(30)22(11-21)28(31,32)33/h1-11,18-19H,12-16H2,(H,34,39)
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n/an/a 2.00E+3n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
In Vitro Electrophysiological Analysis of the Human TASK-1 and TASK-3 Channels Via Two-Electrode Voltage Clamp Technique in Xenopus laevis OocytesSub...


US Patent US10414765 (2019)


BindingDB Entry DOI: 10.7270/Q2QJ7KNV
More data for this
Ligand-Target Pair
Potassium channel subfamily K member 9


(Homo sapiens (Human))
BDBM413560
PNG
(US10414765, Example 44)
Show SMILES FC(F)(F)c1ccc(Cl)c(NC(=O)N2CC3CN(Cc4c(nc5ccccn45)-c4ccc(Br)cc4)CC3C2)c1
Show InChI InChI=1S/C28H24BrClF3N5O/c29-21-7-4-17(5-8-21)26-24(38-10-2-1-3-25(38)35-26)16-36-12-18-14-37(15-19(18)13-36)27(39)34-23-11-20(28(31,32)33)6-9-22(23)30/h1-11,18-19H,12-16H2,(H,34,39)
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n/an/a 2.00E+3n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
In Vitro Electrophysiological Analysis of the Human TASK-1 and TASK-3 Channels Via Two-Electrode Voltage Clamp Technique in Xenopus laevis OocytesSub...


US Patent US10414765 (2019)


BindingDB Entry DOI: 10.7270/Q2QJ7KNV
More data for this
Ligand-Target Pair
Potassium channel subfamily K member 9


(Homo sapiens (Human))
BDBM413547
PNG
(5-{[2-(4-Bromophenyl)imidazo[1,2-a]pyridin-3-yl]me...)
Show SMILES CN(C(=O)N1CC2CN(Cc3c(nc4ccccn34)-c3ccc(Br)cc3)CC2C1)c1ccccc1
Show InChI InChI=1S/C28H28BrN5O/c1-31(24-7-3-2-4-8-24)28(35)33-17-21-15-32(16-22(21)18-33)19-25-27(20-10-12-23(29)13-11-20)30-26-9-5-6-14-34(25)26/h2-14,21-22H,15-19H2,1H3
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n/an/a 2.10E+3n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
In Vitro Electrophysiological Analysis of the Human TASK-1 and TASK-3 Channels Via Two-Electrode Voltage Clamp Technique in Xenopus laevis OocytesSub...


US Patent US10414765 (2019)


BindingDB Entry DOI: 10.7270/Q2QJ7KNV
More data for this
Ligand-Target Pair
Potassium channel subfamily K member 9


(Homo sapiens (Human))
BDBM413562
PNG
(US10414765, Example 46)
Show SMILES CC(NC(=O)N1CC2CN(Cc3c(nc4ccccn34)-c3ccc(Br)cc3)CC2C1)c1ccccc1
Show InChI InChI=1S/C29H30BrN5O/c1-20(21-7-3-2-4-8-21)31-29(36)34-17-23-15-33(16-24(23)18-34)19-26-28(22-10-12-25(30)13-11-22)32-27-9-5-6-14-35(26)27/h2-14,20,23-24H,15-19H2,1H3,(H,31,36)
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n/an/a 2.20E+3n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
In Vitro Electrophysiological Analysis of the Human TASK-1 and TASK-3 Channels Via Two-Electrode Voltage Clamp Technique in Xenopus laevis OocytesSub...


US Patent US10414765 (2019)


BindingDB Entry DOI: 10.7270/Q2QJ7KNV
More data for this
Ligand-Target Pair
Potassium channel subfamily K member 9


(Homo sapiens (Human))
BDBM413512
PNG
(US10414765, Example 4 | [5-{[2-(4-Chlorophenyl)imi...)
Show SMILES COc1cccc(n1)C(=O)N1CC2CN(Cc3c(nc4ccccn34)-c3ccc(Cl)cc3)CC2C1
Show InChI InChI=1S/C27H26ClN5O2/c1-35-25-7-4-5-22(29-25)27(34)32-15-19-13-31(14-20(19)16-32)17-23-26(18-8-10-21(28)11-9-18)30-24-6-2-3-12-33(23)24/h2-12,19-20H,13-17H2,1H3
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n/an/a 2.30E+3n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
In Vitro Electrophysiological Analysis of the Human TASK-1 and TASK-3 Channels Via Two-Electrode Voltage Clamp Technique in Xenopus laevis OocytesSub...


US Patent US10414765 (2019)


BindingDB Entry DOI: 10.7270/Q2QJ7KNV
More data for this
Ligand-Target Pair
Potassium channel protein TASK-1


(Homo sapiens (Human))
BDBM413561
PNG
(US10414765, Example 45)
Show SMILES Brc1ccc(cc1)-c1nc2ccccn2c1CN1CC2CN(CC2C1)C(=O)NC1CCCCC1
Show InChI InChI=1S/C27H32BrN5O/c28-22-11-9-19(10-12-22)26-24(33-13-5-4-8-25(33)30-26)18-31-14-20-16-32(17-21(20)15-31)27(34)29-23-6-2-1-3-7-23/h4-5,8-13,20-21,23H,1-3,6-7,14-18H2,(H,29,34)
PDB

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n/an/a 2.30E+3n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
In Vitro Electrophysiological Analysis of the Human TASK-1 and TASK-3 Channels Via Two-Electrode Voltage Clamp Technique in Xenopus laevis OocytesSub...


US Patent US10414765 (2019)


BindingDB Entry DOI: 10.7270/Q2QJ7KNV
More data for this
Ligand-Target Pair
Potassium channel protein TASK-1


(Homo sapiens (Human))
BDBM413518
PNG
(US10414765, Example 1 | tert-butyl 5-{[2-(4-chloro...)
Show SMILES CC(C)(C)OC(=O)N1CC2CN(Cc3c(nc4ccccn34)-c3ccc(Cl)cc3)CC2C1
Show InChI InChI=1S/C25H29ClN4O2/c1-25(2,3)32-24(31)29-14-18-12-28(13-19(18)15-29)16-21-23(17-7-9-20(26)10-8-17)27-22-6-4-5-11-30(21)22/h4-11,18-19H,12-16H2,1-3H3
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n/an/a 2.41E+3n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
In Vitro Electrophysiological Analysis of the Human TASK-1 and TASK-3 Channels Via Two-Electrode Voltage Clamp Technique in Xenopus laevis OocytesSub...


US Patent US10414765 (2019)


BindingDB Entry DOI: 10.7270/Q2QJ7KNV
More data for this
Ligand-Target Pair
Potassium channel subfamily K member 9


(Homo sapiens (Human))
BDBM413539
PNG
(US10414765, Example 20)
Show SMILES Cc1ccccc1C(=O)N1CC2CN(Cc3c(nc4ccccn34)-c3ccc(Cl)cc3)CC2C1
Show InChI InChI=1S/C28H27ClN4O/c1-19-6-2-3-7-24(19)28(34)32-16-21-14-31(15-22(21)17-32)18-25-27(20-9-11-23(29)12-10-20)30-26-8-4-5-13-33(25)26/h2-13,21-22H,14-18H2,1H3
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n/an/a 2.50E+3n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
In Vitro Electrophysiological Analysis of the Human TASK-1 and TASK-3 Channels Via Two-Electrode Voltage Clamp Technique in Xenopus laevis OocytesSub...


US Patent US10414765 (2019)


BindingDB Entry DOI: 10.7270/Q2QJ7KNV
More data for this
Ligand-Target Pair
Potassium channel subfamily K member 9


(Homo sapiens (Human))
BDBM413531
PNG
(US10414765, Example 11)
Show SMILES COc1ccccc1C(=O)N1CC2CN(Cc3c(nc4ccccn34)-c3ccc(Br)cc3)CC2C1
Show InChI InChI=1S/C28H27BrN4O2/c1-35-25-7-3-2-6-23(25)28(34)32-16-20-14-31(15-21(20)17-32)18-24-27(19-9-11-22(29)12-10-19)30-26-8-4-5-13-33(24)26/h2-13,20-21H,14-18H2,1H3
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n/an/a 2.50E+3n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
In Vitro Electrophysiological Analysis of the Human TASK-1 and TASK-3 Channels Via Two-Electrode Voltage Clamp Technique in Xenopus laevis OocytesSub...


US Patent US10414765 (2019)


BindingDB Entry DOI: 10.7270/Q2QJ7KNV
More data for this
Ligand-Target Pair
Potassium channel protein TASK-1


(Homo sapiens (Human))
BDBM413520
PNG
(US10414765, Example 3)
Show SMILES CC(C)c1ccc(cc1)-c1nc2ccccn2c1CN1CC2CN(CC2C1)C(=O)OC(C)(C)C
Show InChI InChI=1S/C28H36N4O2/c1-19(2)20-9-11-21(12-10-20)26-24(32-13-7-6-8-25(32)29-26)18-30-14-22-16-31(17-23(22)15-30)27(33)34-28(3,4)5/h6-13,19,22-23H,14-18H2,1-5H3
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n/an/a 2.50E+3n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
In Vitro Electrophysiological Analysis of the Human TASK-1 and TASK-3 Channels Via Two-Electrode Voltage Clamp Technique in Xenopus laevis OocytesSub...


US Patent US10414765 (2019)


BindingDB Entry DOI: 10.7270/Q2QJ7KNV
More data for this
Ligand-Target Pair
Potassium channel subfamily K member 9


(Homo sapiens (Human))
BDBM413535
PNG
(US10414765, Example 15)
Show SMILES Fc1ccc(Cl)c(c1)C(=O)N1CC2CN(Cc3c(nc4ccccn34)-c3ccc(Cl)cc3)CC2C1
Show InChI InChI=1S/C27H23Cl2FN4O/c28-20-6-4-17(5-7-20)26-24(34-10-2-1-3-25(34)31-26)16-32-12-18-14-33(15-19(18)13-32)27(35)22-11-21(30)8-9-23(22)29/h1-11,18-19H,12-16H2
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n/an/a 2.90E+3n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
In Vitro Electrophysiological Analysis of the Human TASK-1 and TASK-3 Channels Via Two-Electrode Voltage Clamp Technique in Xenopus laevis OocytesSub...


US Patent US10414765 (2019)


BindingDB Entry DOI: 10.7270/Q2QJ7KNV
More data for this
Ligand-Target Pair
Potassium channel subfamily K member 9


(Homo sapiens (Human))
BDBM413557
PNG
(US10414765, Example 41)
Show SMILES Fc1ccccc1NC(=O)N1CC2CN(Cc3c(nc4ccccn34)-c3ccc(Br)cc3)CC2C1
Show InChI InChI=1S/C27H25BrFN5O/c28-21-10-8-18(9-11-21)26-24(34-12-4-3-7-25(34)31-26)17-32-13-19-15-33(16-20(19)14-32)27(35)30-23-6-2-1-5-22(23)29/h1-12,19-20H,13-17H2,(H,30,35)
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n/an/a 2.90E+3n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
In Vitro Electrophysiological Analysis of the Human TASK-1 and TASK-3 Channels Via Two-Electrode Voltage Clamp Technique in Xenopus laevis OocytesSub...


US Patent US10414765 (2019)


BindingDB Entry DOI: 10.7270/Q2QJ7KNV
More data for this
Ligand-Target Pair
Potassium channel subfamily K member 9


(Homo sapiens (Human))
BDBM413551
PNG
(US10414765, Example 34)
Show SMILES Brc1ccc(cc1)-c1nc2ccccn2c1CN1CC2CN(CC2C1)C(=O)OC1CCCC1
Show InChI InChI=1S/C26H29BrN4O2/c27-21-10-8-18(9-11-21)25-23(31-12-4-3-7-24(31)28-25)17-29-13-19-15-30(16-20(19)14-29)26(32)33-22-5-1-2-6-22/h3-4,7-12,19-20,22H,1-2,5-6,13-17H2
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n/an/a 3.30E+3n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
In Vitro Electrophysiological Analysis of the Human TASK-1 and TASK-3 Channels Via Two-Electrode Voltage Clamp Technique in Xenopus laevis OocytesSub...


US Patent US10414765 (2019)


BindingDB Entry DOI: 10.7270/Q2QJ7KNV
More data for this
Ligand-Target Pair
Potassium channel subfamily K member 9


(Homo sapiens (Human))
BDBM413534
PNG
(US10414765, Example 14)
Show SMILES Fc1ccccc1C(=O)N1CC2CN(Cc3c(nc4ccccn34)-c3ccc(Cl)cc3)CC2C1
Show InChI InChI=1S/C27H24ClFN4O/c28-21-10-8-18(9-11-21)26-24(33-12-4-3-7-25(33)30-26)17-31-13-19-15-32(16-20(19)14-31)27(34)22-5-1-2-6-23(22)29/h1-12,19-20H,13-17H2
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n/an/a 3.40E+3n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
In Vitro Electrophysiological Analysis of the Human TASK-1 and TASK-3 Channels Via Two-Electrode Voltage Clamp Technique in Xenopus laevis OocytesSub...


US Patent US10414765 (2019)


BindingDB Entry DOI: 10.7270/Q2QJ7KNV
More data for this
Ligand-Target Pair
Potassium channel subfamily K member 9


(Homo sapiens (Human))
BDBM413558
PNG
(US10414765, Example 42)
Show SMILES CCOc1ccccc1NC(=O)N1CC2CN(Cc3c(nc4ccccn34)-c3ccc(Br)cc3)CC2C1
Show InChI InChI=1S/C29H30BrN5O2/c1-2-37-26-8-4-3-7-24(26)31-29(36)34-17-21-15-33(16-22(21)18-34)19-25-28(20-10-12-23(30)13-11-20)32-27-9-5-6-14-35(25)27/h3-14,21-22H,2,15-19H2,1H3,(H,31,36)
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n/an/a 3.70E+3n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
In Vitro Electrophysiological Analysis of the Human TASK-1 and TASK-3 Channels Via Two-Electrode Voltage Clamp Technique in Xenopus laevis OocytesSub...


US Patent US10414765 (2019)


BindingDB Entry DOI: 10.7270/Q2QJ7KNV
More data for this
Ligand-Target Pair
Potassium channel subfamily K member 9


(Homo sapiens (Human))
BDBM413525
PNG
(US10414765, Example 7)
Show SMILES Fc1ccc(Cl)c(c1)C(=O)N1CC2CN(Cc3c(nc4ccccn34)-c3ccc(Br)cc3)CC2C1
Show InChI InChI=1S/C27H23BrClFN4O/c28-20-6-4-17(5-7-20)26-24(34-10-2-1-3-25(34)31-26)16-32-12-18-14-33(15-19(18)13-32)27(35)22-11-21(30)8-9-23(22)29/h1-11,18-19H,12-16H2
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n/an/a 4.30E+3n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
In Vitro Electrophysiological Analysis of the Human TASK-1 and TASK-3 Channels Via Two-Electrode Voltage Clamp Technique in Xenopus laevis OocytesSub...


US Patent US10414765 (2019)


BindingDB Entry DOI: 10.7270/Q2QJ7KNV
More data for this
Ligand-Target Pair
Potassium channel subfamily K member 9


(Homo sapiens (Human))
BDBM413550
PNG
(US10414765, Example 33)
Show SMILES Brc1ccc(cc1)-c1nc2ccccn2c1CN1CC2CN(CC2C1)C(=O)OCc1ccccc1
Show InChI InChI=1S/C28H27BrN4O2/c29-24-11-9-21(10-12-24)27-25(33-13-5-4-8-26(33)30-27)18-31-14-22-16-32(17-23(22)15-31)28(34)35-19-20-6-2-1-3-7-20/h1-13,22-23H,14-19H2
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n/an/a 4.40E+3n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
In Vitro Electrophysiological Analysis of the Human TASK-1 and TASK-3 Channels Via Two-Electrode Voltage Clamp Technique in Xenopus laevis OocytesSub...


US Patent US10414765 (2019)


BindingDB Entry DOI: 10.7270/Q2QJ7KNV
More data for this
Ligand-Target Pair
Potassium channel subfamily K member 9


(Homo sapiens (Human))
BDBM413537
PNG
(US10414765, Example 18)
Show SMILES COc1ccccc1C(=O)N1CC2CN(Cc3c(nc4ccccn34)-c3ccc(Cl)cc3)CC2C1
Show InChI InChI=1S/C28H27ClN4O2/c1-35-25-7-3-2-6-23(25)28(34)32-16-20-14-31(15-21(20)17-32)18-24-27(19-9-11-22(29)12-10-19)30-26-8-4-5-13-33(24)26/h2-13,20-21H,14-18H2,1H3
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n/an/a 4.90E+3n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
In Vitro Electrophysiological Analysis of the Human TASK-1 and TASK-3 Channels Via Two-Electrode Voltage Clamp Technique in Xenopus laevis OocytesSub...


US Patent US10414765 (2019)


BindingDB Entry DOI: 10.7270/Q2QJ7KNV
More data for this
Ligand-Target Pair
Potassium channel subfamily K member 9


(Homo sapiens (Human))
BDBM413519
PNG
(US10414765, Example 2)
Show SMILES CC(C)(C)OC(=O)N1CC2CN(Cc3c(nc4ccccn34)-c3ccc(Br)cc3)CC2C1
Show InChI InChI=1S/C25H29BrN4O2/c1-25(2,3)32-24(31)29-14-18-12-28(13-19(18)15-29)16-21-23(17-7-9-20(26)10-8-17)27-22-6-4-5-11-30(21)22/h4-11,18-19H,12-16H2,1-3H3
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n/an/a 5.40E+3n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
In Vitro Electrophysiological Analysis of the Human TASK-1 and TASK-3 Channels Via Two-Electrode Voltage Clamp Technique in Xenopus laevis OocytesSub...


US Patent US10414765 (2019)


BindingDB Entry DOI: 10.7270/Q2QJ7KNV
More data for this
Ligand-Target Pair
Potassium channel subfamily K member 9


(Homo sapiens (Human))
BDBM413561
PNG
(US10414765, Example 45)
Show SMILES Brc1ccc(cc1)-c1nc2ccccn2c1CN1CC2CN(CC2C1)C(=O)NC1CCCCC1
Show InChI InChI=1S/C27H32BrN5O/c28-22-11-9-19(10-12-22)26-24(33-13-5-4-8-25(33)30-26)18-31-14-20-16-32(17-21(20)15-31)27(34)29-23-6-2-1-3-7-23/h4-5,8-13,20-21,23H,1-3,6-7,14-18H2,(H,29,34)
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n/an/a 5.80E+3n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
In Vitro Electrophysiological Analysis of the Human TASK-1 and TASK-3 Channels Via Two-Electrode Voltage Clamp Technique in Xenopus laevis OocytesSub...


US Patent US10414765 (2019)


BindingDB Entry DOI: 10.7270/Q2QJ7KNV
More data for this
Ligand-Target Pair
Potassium channel subfamily K member 9


(Homo sapiens (Human))
BDBM413518
PNG
(US10414765, Example 1 | tert-butyl 5-{[2-(4-chloro...)
Show SMILES CC(C)(C)OC(=O)N1CC2CN(Cc3c(nc4ccccn34)-c3ccc(Cl)cc3)CC2C1
Show InChI InChI=1S/C25H29ClN4O2/c1-25(2,3)32-24(31)29-14-18-12-28(13-19(18)15-29)16-21-23(17-7-9-20(26)10-8-17)27-22-6-4-5-11-30(21)22/h4-11,18-19H,12-16H2,1-3H3
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n/an/a 6.10E+3n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
In Vitro Electrophysiological Analysis of the Human TASK-1 and TASK-3 Channels Via Two-Electrode Voltage Clamp Technique in Xenopus laevis OocytesSub...


US Patent US10414765 (2019)


BindingDB Entry DOI: 10.7270/Q2QJ7KNV
More data for this
Ligand-Target Pair
Potassium channel subfamily K member 9


(Homo sapiens (Human))
BDBM413520
PNG
(US10414765, Example 3)
Show SMILES CC(C)c1ccc(cc1)-c1nc2ccccn2c1CN1CC2CN(CC2C1)C(=O)OC(C)(C)C
Show InChI InChI=1S/C28H36N4O2/c1-19(2)20-9-11-21(12-10-20)26-24(32-13-7-6-8-25(32)29-26)18-30-14-22-16-31(17-23(22)15-30)27(33)34-28(3,4)5/h6-13,19,22-23H,14-18H2,1-5H3
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n/an/a 7.40E+3n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
In Vitro Electrophysiological Analysis of the Human TASK-1 and TASK-3 Channels Via Two-Electrode Voltage Clamp Technique in Xenopus laevis OocytesSub...


US Patent US10414765 (2019)


BindingDB Entry DOI: 10.7270/Q2QJ7KNV
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%