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Patent code US10414797

Compile Data Set for Download or QSAR
Found 100 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Metalloproteinase inhibitor 2


(Cricetulus longicaudatus (Long-tailed dwarf hamste...)
BDBM413584
PNG
((2S,4R)—N-[(1S)-1-[[(1S)-3-benzamido-1-(hydro...)
Show SMILES CCCCCC(=O)N1C[C@H](F)C[C@H]1C(=O)N(C)[C@@H](C(C)CC)C(=O)N[C@@H](CCNC(=O)c1ccccc1)C(=O)NO
Show InChI InChI=1S/C29H44FN5O6/c1-5-7-9-14-24(36)35-18-21(30)17-23(35)29(40)34(4)25(19(3)6-2)28(39)32-22(27(38)33-41)15-16-31-26(37)20-12-10-8-11-13-20/h8,10-13,19,21-23,25,41H,5-7,9,14-18H2,1-4H3,(H,31,37)(H,32,39)(H,33,38)/t19?,21-,22+,23+,25+/m1/s1
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n/an/a<1n/an/an/an/an/an/a



Iproteos S.L

US Patent


Assay Description
MMP-2: Recombinant MMP-2 expressed in Chinese hamster ovary (CHO) cells was obtained from Merck-Millipore (catalog number PF023-5UG). DQ gelatin from...


US Patent US10414797 (2019)


BindingDB Entry DOI: 10.7270/Q2KS6TWP
More data for this
Ligand-Target Pair
Matrix metalloproteinase-9


(Homo sapiens (Human))
BDBM413584
PNG
((2S,4R)—N-[(1S)-1-[[(1S)-3-benzamido-1-(hydro...)
Show SMILES CCCCCC(=O)N1C[C@H](F)C[C@H]1C(=O)N(C)[C@@H](C(C)CC)C(=O)N[C@@H](CCNC(=O)c1ccccc1)C(=O)NO
Show InChI InChI=1S/C29H44FN5O6/c1-5-7-9-14-24(36)35-18-21(30)17-23(35)29(40)34(4)25(19(3)6-2)28(39)32-22(27(38)33-41)15-16-31-26(37)20-12-10-8-11-13-20/h8,10-13,19,21-23,25,41H,5-7,9,14-18H2,1-4H3,(H,31,37)(H,32,39)(H,33,38)/t19?,21-,22+,23+,25+/m1/s1
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Iproteos S.L

US Patent


Assay Description
MMP-9: Recombinant MMP-9 expressed was obtained from Merck-Millipore (catalog number PF140-5UG, used in examples 1 to 9 and comparative examples) and...


US Patent US10414797 (2019)


BindingDB Entry DOI: 10.7270/Q2KS6TWP
More data for this
Ligand-Target Pair
Metalloproteinase inhibitor 2


(Cricetulus longicaudatus (Long-tailed dwarf hamste...)
BDBM413580
PNG
((2 S)-1-[(2S)-2-[acetyl(methyl)amino]propanoyl]-N-...)
Show SMILES CCC(C)[C@H](N(C)C(=O)[C@@H]1CCCN1C(=O)[C@H](C)N(C)C(C)=O)C(=O)N[C@@H](CCNC(=O)c1cc(F)cc(F)c1)C(=O)NO
Show InChI InChI=1S/C29H42F2N6O7/c1-7-16(2)24(36(6)29(43)23-9-8-12-37(23)28(42)17(3)35(5)18(4)38)27(41)33-22(26(40)34-44)10-11-32-25(39)19-13-20(30)15-21(31)14-19/h13-17,22-24,44H,7-12H2,1-6H3,(H,32,39)(H,33,41)(H,34,40)/t16?,17-,22-,23-,24-/m0/s1
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n/an/a 21n/an/an/an/an/an/a



Iproteos S.L

US Patent


Assay Description
MMP-2: Recombinant MMP-2 expressed in Chinese hamster ovary (CHO) cells was obtained from Merck-Millipore (catalog number PF023-5UG). DQ gelatin from...


US Patent US10414797 (2019)


BindingDB Entry DOI: 10.7270/Q2KS6TWP
More data for this
Ligand-Target Pair
Metalloproteinase inhibitor 2


(Cricetulus longicaudatus (Long-tailed dwarf hamste...)
BDBM413577
PNG
((2S)—N-[(1S)-1-[[(1S)-3-[(3,5-difluorobenzoyl...)
Show SMILES CCC(C)[C@H](N(C)C(=O)[C@@H]1CC(F)(F)CN1C(=O)CCCOc1ccccc1)C(=O)N[C@@H](CCNC(=O)c1cc(F)cc(F)c1)C(=O)NO
Show InChI InChI=1S/C33H41F4N5O7/c1-4-20(2)28(31(46)39-25(30(45)40-48)12-13-38-29(44)21-15-22(34)17-23(35)16-21)41(3)32(47)26-18-33(36,37)19-42(26)27(43)11-8-14-49-24-9-6-5-7-10-24/h5-7,9-10,15-17,20,25-26,28,48H,4,8,11-14,18-19H2,1-3H3,(H,38,44)(H,39,46)(H,40,45)/t20?,25-,26-,28-/m0/s1
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n/an/a 37n/an/an/an/an/an/a



Iproteos S.L

US Patent


Assay Description
MMP-2: Recombinant MMP-2 expressed in Chinese hamster ovary (CHO) cells was obtained from Merck-Millipore (catalog number PF023-5UG). DQ gelatin from...


US Patent US10414797 (2019)


BindingDB Entry DOI: 10.7270/Q2KS6TWP
More data for this
Ligand-Target Pair
Matrix metalloproteinase-9


(Homo sapiens (Human))
BDBM413582
PNG
((2S)-1-[(2S)-2-[[(2S)-2-[butanoyl(methyl)amino]-3-...)
Show SMILES CCCC(=O)N(C)[C@@H](Cc1c[nH]c2ccccc12)C(=O)N(C)[C@@H](CC(C)C)C(=O)N1CCC[C@H]1C(=O)N(C)[C@@H](C(C)CC)C(=O)N[C@@H](CCNC(=O)c1cc(F)cc(F)c1)C(=O)NO
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Iproteos S.L

US Patent


Assay Description
MMP-9: Recombinant MMP-9 expressed was obtained from Merck-Millipore (catalog number PF140-5UG, used in examples 1 to 9 and comparative examples) and...


US Patent US10414797 (2019)


BindingDB Entry DOI: 10.7270/Q2KS6TWP
More data for this
Ligand-Target Pair
Metalloproteinase inhibitor 2


(Cricetulus longicaudatus (Long-tailed dwarf hamste...)
BDBM413571
PNG
((2S)-1-butanoyl-N-[(1S)-1-[[(1S)-3-[(3,5-difluorob...)
Show SMILES CCCC(=O)N1CCC[C@H]1C(=O)N(C)[C@@H](C(C)CC)C(=O)N[C@@H](CCNC(=O)c1cc(F)cc(F)c1)C(=O)NO
Show InChI InChI=1S/C27H39F2N5O6/c1-5-8-22(35)34-12-7-9-21(34)27(39)33(4)23(16(3)6-2)26(38)31-20(25(37)32-40)10-11-30-24(36)17-13-18(28)15-19(29)14-17/h13-16,20-21,23,40H,5-12H2,1-4H3,(H,30,36)(H,31,38)(H,32,37)/t16?,20-,21-,23-/m0/s1
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n/an/a 62n/an/an/an/an/an/a



Iproteos S.L

US Patent


Assay Description
MMP-2: Recombinant MMP-2 expressed in Chinese hamster ovary (CHO) cells was obtained from Merck-Millipore (catalog number PF023-5UG). DQ gelatin from...


US Patent US10414797 (2019)


BindingDB Entry DOI: 10.7270/Q2KS6TWP
More data for this
Ligand-Target Pair
Matrix metalloproteinase-9


(Homo sapiens (Human))
BDBM413579
PNG
((2 S)-1-[(2S)-2-[acetyl(methyl)amino]-3-phenyl-pro...)
Show SMILES CCC(C)[C@H](N(C)C(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccccc1)N(C)C(C)=O)C(=O)N[C@@H](CCNC(=O)c1cc(F)cc(F)c1)C(=O)NO
Show InChI InChI=1S/C35H46F2N6O7/c1-6-21(2)30(33(47)39-27(32(46)40-50)14-15-38-31(45)24-18-25(36)20-26(37)19-24)42(5)34(48)28-13-10-16-43(28)35(49)29(41(4)22(3)44)17-23-11-8-7-9-12-23/h7-9,11-12,18-21,27-30,50H,6,10,13-17H2,1-5H3,(H,38,45)(H,39,47)(H,40,46)/t21?,27-,28-,29-,30-/m0/s1
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Iproteos S.L

US Patent


Assay Description
MMP-9: Recombinant MMP-9 expressed was obtained from Merck-Millipore (catalog number PF140-5UG, used in examples 1 to 9 and comparative examples) and...


US Patent US10414797 (2019)


BindingDB Entry DOI: 10.7270/Q2KS6TWP
More data for this
Ligand-Target Pair
Metalloproteinase inhibitor 2


(Cricetulus longicaudatus (Long-tailed dwarf hamste...)
BDBM413570
PNG
((2S)—N-[(1S)-1-[[(1S)-3-[(3,5-difluorobenzoyl...)
Show SMILES CCCCCC(=O)N1CCC[C@H]1C(=O)N(C)[C@@H](C(C)CC)C(=O)N[C@@H](CCNC(=O)c1cc(F)cc(F)c1)C(=O)NO
Show InChI InChI=1S/C29H43F2N5O6/c1-5-7-8-11-24(37)36-14-9-10-23(36)29(41)35(4)25(18(3)6-2)28(40)33-22(27(39)34-42)12-13-32-26(38)19-15-20(30)17-21(31)16-19/h15-18,22-23,25,42H,5-14H2,1-4H3,(H,32,38)(H,33,40)(H,34,39)/t18?,22-,23-,25-/m0/s1
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n/an/a 81n/an/an/an/an/an/a



Iproteos S.L

US Patent


Assay Description
MMP-2: Recombinant MMP-2 expressed in Chinese hamster ovary (CHO) cells was obtained from Merck-Millipore (catalog number PF023-5UG). DQ gelatin from...


US Patent US10414797 (2019)


BindingDB Entry DOI: 10.7270/Q2KS6TWP
More data for this
Ligand-Target Pair
Metalloproteinase inhibitor 2


(Cricetulus longicaudatus (Long-tailed dwarf hamste...)
BDBM413572
PNG
((2S)—N-[(1S)-1-[[(1S)-3-[(3,5-difluorobenzoyl...)
Show SMILES CCC(C)[C@H](N(C)C(=O)[C@@H]1CCCN1C(=O)CC(C)C)C(=O)N[C@@H](CCNC(=O)c1cc(F)cc(F)c1)C(=O)NO
Show InChI InChI=1S/C28H41F2N5O6/c1-6-17(4)24(34(5)28(40)22-8-7-11-35(22)23(36)12-16(2)3)27(39)32-21(26(38)33-41)9-10-31-25(37)18-13-19(29)15-20(30)14-18/h13-17,21-22,24,41H,6-12H2,1-5H3,(H,31,37)(H,32,39)(H,33,38)/t17?,21-,22-,24-/m0/s1
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n/an/a 116n/an/an/an/an/an/a



Iproteos S.L

US Patent


Assay Description
MMP-2: Recombinant MMP-2 expressed in Chinese hamster ovary (CHO) cells was obtained from Merck-Millipore (catalog number PF023-5UG). DQ gelatin from...


US Patent US10414797 (2019)


BindingDB Entry DOI: 10.7270/Q2KS6TWP
More data for this
Ligand-Target Pair
Metalloproteinase inhibitor 2


(Cricetulus longicaudatus (Long-tailed dwarf hamste...)
BDBM413582
PNG
((2S)-1-[(2S)-2-[[(2S)-2-[butanoyl(methyl)amino]-3-...)
Show SMILES CCCC(=O)N(C)[C@@H](Cc1c[nH]c2ccccc12)C(=O)N(C)[C@@H](CC(C)C)C(=O)N1CCC[C@H]1C(=O)N(C)[C@@H](C(C)CC)C(=O)N[C@@H](CCNC(=O)c1cc(F)cc(F)c1)C(=O)NO
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n/an/a 116n/an/an/an/an/an/a



Iproteos S.L

US Patent


Assay Description
MMP-2: Recombinant MMP-2 expressed in Chinese hamster ovary (CHO) cells was obtained from Merck-Millipore (catalog number PF023-5UG). DQ gelatin from...


US Patent US10414797 (2019)


BindingDB Entry DOI: 10.7270/Q2KS6TWP
More data for this
Ligand-Target Pair
Matrix metalloproteinase-9


(Homo sapiens (Human))
BDBM413580
PNG
((2 S)-1-[(2S)-2-[acetyl(methyl)amino]propanoyl]-N-...)
Show SMILES CCC(C)[C@H](N(C)C(=O)[C@@H]1CCCN1C(=O)[C@H](C)N(C)C(C)=O)C(=O)N[C@@H](CCNC(=O)c1cc(F)cc(F)c1)C(=O)NO
Show InChI InChI=1S/C29H42F2N6O7/c1-7-16(2)24(36(6)29(43)23-9-8-12-37(23)28(42)17(3)35(5)18(4)38)27(41)33-22(26(40)34-44)10-11-32-25(39)19-13-20(30)15-21(31)14-19/h13-17,22-24,44H,7-12H2,1-6H3,(H,32,39)(H,33,41)(H,34,40)/t16?,17-,22-,23-,24-/m0/s1
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Iproteos S.L

US Patent


Assay Description
MMP-9: Recombinant MMP-9 expressed was obtained from Merck-Millipore (catalog number PF140-5UG, used in examples 1 to 9 and comparative examples) and...


US Patent US10414797 (2019)


BindingDB Entry DOI: 10.7270/Q2KS6TWP
More data for this
Ligand-Target Pair
Metalloproteinase inhibitor 2


(Cricetulus longicaudatus (Long-tailed dwarf hamste...)
BDBM413574
PNG
((2S)—N-[(1S)-1-[[(1S)-3-[(3,5-difluorobenzoyl...)
Show SMILES CCCCCC(=O)N1CC(F)(F)C[C@H]1C(=O)N(C)[C@@H](C(C)CC)C(=O)N[C@@H](CCNC(=O)c1cc(F)cc(F)c1)C(=O)NO
Show InChI InChI=1S/C29H41F4N5O6/c1-5-7-8-9-23(39)38-16-29(32,33)15-22(38)28(43)37(4)24(17(3)6-2)27(42)35-21(26(41)36-44)10-11-34-25(40)18-12-19(30)14-20(31)13-18/h12-14,17,21-22,24,44H,5-11,15-16H2,1-4H3,(H,34,40)(H,35,42)(H,36,41)/t17?,21-,22-,24-/m0/s1
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n/an/a 159n/an/an/an/an/an/a



Iproteos S.L

US Patent


Assay Description
MMP-2: Recombinant MMP-2 expressed in Chinese hamster ovary (CHO) cells was obtained from Merck-Millipore (catalog number PF023-5UG). DQ gelatin from...


US Patent US10414797 (2019)


BindingDB Entry DOI: 10.7270/Q2KS6TWP
More data for this
Ligand-Target Pair
Metalloproteinase inhibitor 2


(Cricetulus longicaudatus (Long-tailed dwarf hamste...)
BDBM413579
PNG
((2 S)-1-[(2S)-2-[acetyl(methyl)amino]-3-phenyl-pro...)
Show SMILES CCC(C)[C@H](N(C)C(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccccc1)N(C)C(C)=O)C(=O)N[C@@H](CCNC(=O)c1cc(F)cc(F)c1)C(=O)NO
Show InChI InChI=1S/C35H46F2N6O7/c1-6-21(2)30(33(47)39-27(32(46)40-50)14-15-38-31(45)24-18-25(36)20-26(37)19-24)42(5)34(48)28-13-10-16-43(28)35(49)29(41(4)22(3)44)17-23-11-8-7-9-12-23/h7-9,11-12,18-21,27-30,50H,6,10,13-17H2,1-5H3,(H,38,45)(H,39,47)(H,40,46)/t21?,27-,28-,29-,30-/m0/s1
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n/an/a 174n/an/an/an/an/an/a



Iproteos S.L

US Patent


Assay Description
MMP-2: Recombinant MMP-2 expressed in Chinese hamster ovary (CHO) cells was obtained from Merck-Millipore (catalog number PF023-5UG). DQ gelatin from...


US Patent US10414797 (2019)


BindingDB Entry DOI: 10.7270/Q2KS6TWP
More data for this
Ligand-Target Pair
Metalloproteinase inhibitor 2


(Cricetulus longicaudatus (Long-tailed dwarf hamste...)
BDBM413568
PNG
((2S)-1-acetyl-N-[(1S)-1-[[(1S)-3-[(4-fluorobenzoyl...)
Show SMILES CCC(C)[C@H](N(C)C(=O)[C@@H]1CCCN1C(C)=O)C(=O)N[C@@H](CCNC(=O)c1ccc(F)cc1)C(=O)NO
Show InChI InChI=1S/C25H36FN5O6/c1-5-15(2)21(30(4)25(36)20-7-6-14-31(20)16(3)32)24(35)28-19(23(34)29-37)12-13-27-22(33)17-8-10-18(26)11-9-17/h8-11,15,19-21,37H,5-7,12-14H2,1-4H3,(H,27,33)(H,28,35)(H,29,34)/t15?,19-,20-,21-/m0/s1
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n/an/a 202n/an/an/an/an/an/a



Iproteos S.L

US Patent


Assay Description
MMP-2: Recombinant MMP-2 expressed in Chinese hamster ovary (CHO) cells was obtained from Merck-Millipore (catalog number PF023-5UG). DQ gelatin from...


US Patent US10414797 (2019)


BindingDB Entry DOI: 10.7270/Q2KS6TWP
More data for this
Ligand-Target Pair
Matrix metalloproteinase-9


(Homo sapiens (Human))
BDBM413577
PNG
((2S)—N-[(1S)-1-[[(1S)-3-[(3,5-difluorobenzoyl...)
Show SMILES CCC(C)[C@H](N(C)C(=O)[C@@H]1CC(F)(F)CN1C(=O)CCCOc1ccccc1)C(=O)N[C@@H](CCNC(=O)c1cc(F)cc(F)c1)C(=O)NO
Show InChI InChI=1S/C33H41F4N5O7/c1-4-20(2)28(31(46)39-25(30(45)40-48)12-13-38-29(44)21-15-22(34)17-23(35)16-21)41(3)32(47)26-18-33(36,37)19-42(26)27(43)11-8-14-49-24-9-6-5-7-10-24/h5-7,9-10,15-17,20,25-26,28,48H,4,8,11-14,18-19H2,1-3H3,(H,38,44)(H,39,46)(H,40,45)/t20?,25-,26-,28-/m0/s1
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Iproteos S.L

US Patent


Assay Description
MMP-9: Recombinant MMP-9 expressed was obtained from Merck-Millipore (catalog number PF140-5UG, used in examples 1 to 9 and comparative examples) and...


US Patent US10414797 (2019)


BindingDB Entry DOI: 10.7270/Q2KS6TWP
More data for this
Ligand-Target Pair
Matrix metalloproteinase-9


(Homo sapiens (Human))
BDBM413571
PNG
((2S)-1-butanoyl-N-[(1S)-1-[[(1S)-3-[(3,5-difluorob...)
Show SMILES CCCC(=O)N1CCC[C@H]1C(=O)N(C)[C@@H](C(C)CC)C(=O)N[C@@H](CCNC(=O)c1cc(F)cc(F)c1)C(=O)NO
Show InChI InChI=1S/C27H39F2N5O6/c1-5-8-22(35)34-12-7-9-21(34)27(39)33(4)23(16(3)6-2)26(38)31-20(25(37)32-40)10-11-30-24(36)17-13-18(28)15-19(29)14-17/h13-16,20-21,23,40H,5-12H2,1-4H3,(H,30,36)(H,31,38)(H,32,37)/t16?,20-,21-,23-/m0/s1
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n/an/a 235n/an/an/an/an/an/a



Iproteos S.L

US Patent


Assay Description
MMP-9: Recombinant MMP-9 expressed was obtained from Merck-Millipore (catalog number PF140-5UG, used in examples 1 to 9 and comparative examples) and...


US Patent US10414797 (2019)


BindingDB Entry DOI: 10.7270/Q2KS6TWP
More data for this
Ligand-Target Pair
Metalloproteinase inhibitor 2


(Cricetulus longicaudatus (Long-tailed dwarf hamste...)
BDBM413569
PNG
((2S)-1-acetyl-N-[(1S)-1-[[(1S)-3-[(3,5-difluoroben...)
Show SMILES CCC(C)[C@H](N(C)C(=O)[C@@H]1CCCN1C(C)=O)C(=O)N[C@@H](CCNC(=O)c1cc(F)cc(F)c1)C(=O)NO
Show InChI InChI=1S/C25H35F2N5O6/c1-5-14(2)21(31(4)25(37)20-7-6-10-32(20)15(3)33)24(36)29-19(23(35)30-38)8-9-28-22(34)16-11-17(26)13-18(27)12-16/h11-14,19-21,38H,5-10H2,1-4H3,(H,28,34)(H,29,36)(H,30,35)/t14?,19-,20-,21-/m0/s1
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n/an/a 242n/an/an/an/an/an/a



Iproteos S.L

US Patent


Assay Description
MMP-2: Recombinant MMP-2 expressed in Chinese hamster ovary (CHO) cells was obtained from Merck-Millipore (catalog number PF023-5UG). DQ gelatin from...


US Patent US10414797 (2019)


BindingDB Entry DOI: 10.7270/Q2KS6TWP
More data for this
Ligand-Target Pair
Matrix metalloproteinase-9


(Homo sapiens (Human))
BDBM413575
PNG
((2S)—N-[(1S)-1-[[(1S)-3-[(3,5-difluorobenzoyl...)
Show SMILES CCCC(CCC)C(=O)N1CCC[C@H]1C(=O)N(C)[C@@H](C(C)CC)C(=O)N[C@@H](CCNC(=O)c1cc(F)cc(F)c1)C(=O)NO
Show InChI InChI=1S/C31H47F2N5O6/c1-6-10-20(11-7-2)30(42)38-15-9-12-25(38)31(43)37(5)26(19(4)8-3)29(41)35-24(28(40)36-44)13-14-34-27(39)21-16-22(32)18-23(33)17-21/h16-20,24-26,44H,6-15H2,1-5H3,(H,34,39)(H,35,41)(H,36,40)/t19?,24-,25-,26-/m0/s1
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n/an/a 263n/an/an/an/an/an/a



Iproteos S.L

US Patent


Assay Description
MMP-9: Recombinant MMP-9 expressed was obtained from Merck-Millipore (catalog number PF140-5UG, used in examples 1 to 9 and comparative examples) and...


US Patent US10414797 (2019)


BindingDB Entry DOI: 10.7270/Q2KS6TWP
More data for this
Ligand-Target Pair
Metalloproteinase inhibitor 2


(Cricetulus longicaudatus (Long-tailed dwarf hamste...)
BDBM413583
PNG
((2S)—N-[(1S)-1-[[(1S)-3-benzamido-1-(hydroxyc...)
Show SMILES CCCCCC(=O)N1CCC[C@H]1C(=O)N(C)[C@@H](C(C)CC)C(=O)N[C@@H](CCNC(=O)c1ccccc1)C(=O)NO
Show InChI InChI=1S/C29H45N5O6/c1-5-7-9-16-24(35)34-19-12-15-23(34)29(39)33(4)25(20(3)6-2)28(38)31-22(27(37)32-40)17-18-30-26(36)21-13-10-8-11-14-21/h8,10-11,13-14,20,22-23,25,40H,5-7,9,12,15-19H2,1-4H3,(H,30,36)(H,31,38)(H,32,37)/t20?,22-,23-,25-/m0/s1
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n/an/a 285n/an/an/an/an/an/a



Iproteos S.L

US Patent


Assay Description
MMP-2: Recombinant MMP-2 expressed in Chinese hamster ovary (CHO) cells was obtained from Merck-Millipore (catalog number PF023-5UG). DQ gelatin from...


US Patent US10414797 (2019)


BindingDB Entry DOI: 10.7270/Q2KS6TWP
More data for this
Ligand-Target Pair
Matrix metalloproteinase-9


(Homo sapiens (Human))
BDBM413569
PNG
((2S)-1-acetyl-N-[(1S)-1-[[(1S)-3-[(3,5-difluoroben...)
Show SMILES CCC(C)[C@H](N(C)C(=O)[C@@H]1CCCN1C(C)=O)C(=O)N[C@@H](CCNC(=O)c1cc(F)cc(F)c1)C(=O)NO
Show InChI InChI=1S/C25H35F2N5O6/c1-5-14(2)21(31(4)25(37)20-7-6-10-32(20)15(3)33)24(36)29-19(23(35)30-38)8-9-28-22(34)16-11-17(26)13-18(27)12-16/h11-14,19-21,38H,5-10H2,1-4H3,(H,28,34)(H,29,36)(H,30,35)/t14?,19-,20-,21-/m0/s1
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n/an/a 301n/an/an/an/an/an/a



Iproteos S.L

US Patent


Assay Description
MMP-9: Recombinant MMP-9 expressed was obtained from Merck-Millipore (catalog number PF140-5UG, used in examples 1 to 9 and comparative examples) and...


US Patent US10414797 (2019)


BindingDB Entry DOI: 10.7270/Q2KS6TWP
More data for this
Ligand-Target Pair
Matrix metalloproteinase-9


(Homo sapiens (Human))
BDBM413581
PNG
((2S)-1-[3-[acetyl(methyl)amino]propanoyl]-N-[(1S)-...)
Show SMILES CCC(C)[C@H](N(C)C(=O)[C@@H]1CCCN1C(=O)CCN(C)C(C)=O)C(=O)N[C@@H](CCNC(=O)c1cc(F)cc(F)c1)C(=O)NO
Show InChI InChI=1S/C29H42F2N6O7/c1-6-17(2)25(36(5)29(43)23-8-7-12-37(23)24(39)10-13-35(4)18(3)38)28(42)33-22(27(41)34-44)9-11-32-26(40)19-14-20(30)16-21(31)15-19/h14-17,22-23,25,44H,6-13H2,1-5H3,(H,32,40)(H,33,42)(H,34,41)/t17?,22-,23-,25-/m0/s1
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n/an/a 339n/an/an/an/an/an/a



Iproteos S.L

US Patent


Assay Description
MMP-9: Recombinant MMP-9 expressed was obtained from Merck-Millipore (catalog number PF140-5UG, used in examples 1 to 9 and comparative examples) and...


US Patent US10414797 (2019)


BindingDB Entry DOI: 10.7270/Q2KS6TWP
More data for this
Ligand-Target Pair
Metalloproteinase inhibitor 2


(Cricetulus longicaudatus (Long-tailed dwarf hamste...)
BDBM413576
PNG
((2S)—N-[(1S)-1-[[(1S)-3-[(3,5-difluorobenzoyl...)
Show SMILES CCC(C)[C@H](N(C)C(=O)[C@@H]1CCCN1C(=O)CCCOc1ccccc1)C(=O)N[C@@H](CCNC(=O)c1cc(F)cc(F)c1)C(=O)NO
Show InChI InChI=1S/C33H43F2N5O7/c1-4-21(2)29(32(44)37-26(31(43)38-46)14-15-36-30(42)22-18-23(34)20-24(35)19-22)39(3)33(45)27-12-8-16-40(27)28(41)13-9-17-47-25-10-6-5-7-11-25/h5-7,10-11,18-21,26-27,29,46H,4,8-9,12-17H2,1-3H3,(H,36,42)(H,37,44)(H,38,43)/t21?,26-,27-,29-/m0/s1
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n/an/a 362n/an/an/an/an/an/a



Iproteos S.L

US Patent


Assay Description
MMP-2: Recombinant MMP-2 expressed in Chinese hamster ovary (CHO) cells was obtained from Merck-Millipore (catalog number PF023-5UG). DQ gelatin from...


US Patent US10414797 (2019)


BindingDB Entry DOI: 10.7270/Q2KS6TWP
More data for this
Ligand-Target Pair
Matrix metalloproteinase-9


(Homo sapiens (Human))
BDBM413570
PNG
((2S)—N-[(1S)-1-[[(1S)-3-[(3,5-difluorobenzoyl...)
Show SMILES CCCCCC(=O)N1CCC[C@H]1C(=O)N(C)[C@@H](C(C)CC)C(=O)N[C@@H](CCNC(=O)c1cc(F)cc(F)c1)C(=O)NO
Show InChI InChI=1S/C29H43F2N5O6/c1-5-7-8-11-24(37)36-14-9-10-23(36)29(41)35(4)25(18(3)6-2)28(40)33-22(27(39)34-42)12-13-32-26(38)19-15-20(30)17-21(31)16-19/h15-18,22-23,25,42H,5-14H2,1-4H3,(H,32,38)(H,33,40)(H,34,39)/t18?,22-,23-,25-/m0/s1
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n/an/a 395n/an/an/an/an/an/a



Iproteos S.L

US Patent


Assay Description
MMP-9: Recombinant MMP-9 expressed was obtained from Merck-Millipore (catalog number PF140-5UG, used in examples 1 to 9 and comparative examples) and...


US Patent US10414797 (2019)


BindingDB Entry DOI: 10.7270/Q2KS6TWP
More data for this
Ligand-Target Pair
Metalloproteinase inhibitor 2


(Cricetulus longicaudatus (Long-tailed dwarf hamste...)
BDBM413573
PNG
((2S)—N-[(1S)-1-[[(1S)-3-[(3,5-difluorobenzoyl...)
Show SMILES CCCCCCCC(=O)N1CCC[C@H]1C(=O)N(C)[C@@H](C(C)CC)C(=O)N[C@@H](CCNC(=O)c1cc(F)cc(F)c1)C(=O)NO
Show InChI InChI=1S/C31H47F2N5O6/c1-5-7-8-9-10-13-26(39)38-16-11-12-25(38)31(43)37(4)27(20(3)6-2)30(42)35-24(29(41)36-44)14-15-34-28(40)21-17-22(32)19-23(33)18-21/h17-20,24-25,27,44H,5-16H2,1-4H3,(H,34,40)(H,35,42)(H,36,41)/t20?,24-,25-,27-/m0/s1
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n/an/a 400n/an/an/an/an/an/a



Iproteos S.L

US Patent


Assay Description
MMP-2: Recombinant MMP-2 expressed in Chinese hamster ovary (CHO) cells was obtained from Merck-Millipore (catalog number PF023-5UG). DQ gelatin from...


US Patent US10414797 (2019)


BindingDB Entry DOI: 10.7270/Q2KS6TWP
More data for this
Ligand-Target Pair
Matrix metalloproteinase-9


(Homo sapiens (Human))
BDBM413576
PNG
((2S)—N-[(1S)-1-[[(1S)-3-[(3,5-difluorobenzoyl...)
Show SMILES CCC(C)[C@H](N(C)C(=O)[C@@H]1CCCN1C(=O)CCCOc1ccccc1)C(=O)N[C@@H](CCNC(=O)c1cc(F)cc(F)c1)C(=O)NO
Show InChI InChI=1S/C33H43F2N5O7/c1-4-21(2)29(32(44)37-26(31(43)38-46)14-15-36-30(42)22-18-23(34)20-24(35)19-22)39(3)33(45)27-12-8-16-40(27)28(41)13-9-17-47-25-10-6-5-7-11-25/h5-7,10-11,18-21,26-27,29,46H,4,8-9,12-17H2,1-3H3,(H,36,42)(H,37,44)(H,38,43)/t21?,26-,27-,29-/m0/s1
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n/an/a 506n/an/an/an/an/an/a



Iproteos S.L

US Patent


Assay Description
MMP-9: Recombinant MMP-9 expressed was obtained from Merck-Millipore (catalog number PF140-5UG, used in examples 1 to 9 and comparative examples) and...


US Patent US10414797 (2019)


BindingDB Entry DOI: 10.7270/Q2KS6TWP
More data for this
Ligand-Target Pair
Matrix metalloproteinase-9


(Homo sapiens (Human))
BDBM413572
PNG
((2S)—N-[(1S)-1-[[(1S)-3-[(3,5-difluorobenzoyl...)
Show SMILES CCC(C)[C@H](N(C)C(=O)[C@@H]1CCCN1C(=O)CC(C)C)C(=O)N[C@@H](CCNC(=O)c1cc(F)cc(F)c1)C(=O)NO
Show InChI InChI=1S/C28H41F2N5O6/c1-6-17(4)24(34(5)28(40)22-8-7-11-35(22)23(36)12-16(2)3)27(39)32-21(26(38)33-41)9-10-31-25(37)18-13-19(29)15-20(30)14-18/h13-17,21-22,24,41H,6-12H2,1-5H3,(H,31,37)(H,32,39)(H,33,38)/t17?,21-,22-,24-/m0/s1
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n/an/a 601n/an/an/an/an/an/a



Iproteos S.L

US Patent


Assay Description
MMP-9: Recombinant MMP-9 expressed was obtained from Merck-Millipore (catalog number PF140-5UG, used in examples 1 to 9 and comparative examples) and...


US Patent US10414797 (2019)


BindingDB Entry DOI: 10.7270/Q2KS6TWP
More data for this
Ligand-Target Pair
Matrix metalloproteinase-9


(Homo sapiens (Human))
BDBM413583
PNG
((2S)—N-[(1S)-1-[[(1S)-3-benzamido-1-(hydroxyc...)
Show SMILES CCCCCC(=O)N1CCC[C@H]1C(=O)N(C)[C@@H](C(C)CC)C(=O)N[C@@H](CCNC(=O)c1ccccc1)C(=O)NO
Show InChI InChI=1S/C29H45N5O6/c1-5-7-9-16-24(35)34-19-12-15-23(34)29(39)33(4)25(20(3)6-2)28(38)31-22(27(37)32-40)17-18-30-26(36)21-13-10-8-11-14-21/h8,10-11,13-14,20,22-23,25,40H,5-7,9,12,15-19H2,1-4H3,(H,30,36)(H,31,38)(H,32,37)/t20?,22-,23-,25-/m0/s1
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n/an/a 702n/an/an/an/an/an/a



Iproteos S.L

US Patent


Assay Description
MMP-9: Recombinant MMP-9 expressed was obtained from Merck-Millipore (catalog number PF140-5UG, used in examples 1 to 9 and comparative examples) and...


US Patent US10414797 (2019)


BindingDB Entry DOI: 10.7270/Q2KS6TWP
More data for this
Ligand-Target Pair
Matrix metalloproteinase-9


(Homo sapiens (Human))
BDBM413574
PNG
((2S)—N-[(1S)-1-[[(1S)-3-[(3,5-difluorobenzoyl...)
Show SMILES CCCCCC(=O)N1CC(F)(F)C[C@H]1C(=O)N(C)[C@@H](C(C)CC)C(=O)N[C@@H](CCNC(=O)c1cc(F)cc(F)c1)C(=O)NO
Show InChI InChI=1S/C29H41F4N5O6/c1-5-7-8-9-23(39)38-16-29(32,33)15-22(38)28(43)37(4)24(17(3)6-2)27(42)35-21(26(41)36-44)10-11-34-25(40)18-12-19(30)14-20(31)13-18/h12-14,17,21-22,24,44H,5-11,15-16H2,1-4H3,(H,34,40)(H,35,42)(H,36,41)/t17?,21-,22-,24-/m0/s1
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n/an/a 713n/an/an/an/an/an/a



Iproteos S.L

US Patent


Assay Description
MMP-9: Recombinant MMP-9 expressed was obtained from Merck-Millipore (catalog number PF140-5UG, used in examples 1 to 9 and comparative examples) and...


US Patent US10414797 (2019)


BindingDB Entry DOI: 10.7270/Q2KS6TWP
More data for this
Ligand-Target Pair
Matrix metalloproteinase-9


(Homo sapiens (Human))
BDBM413573
PNG
((2S)—N-[(1S)-1-[[(1S)-3-[(3,5-difluorobenzoyl...)
Show SMILES CCCCCCCC(=O)N1CCC[C@H]1C(=O)N(C)[C@@H](C(C)CC)C(=O)N[C@@H](CCNC(=O)c1cc(F)cc(F)c1)C(=O)NO
Show InChI InChI=1S/C31H47F2N5O6/c1-5-7-8-9-10-13-26(39)38-16-11-12-25(38)31(43)37(4)27(20(3)6-2)30(42)35-24(29(41)36-44)14-15-34-28(40)21-17-22(32)19-23(33)18-21/h17-20,24-25,27,44H,5-16H2,1-4H3,(H,34,40)(H,35,42)(H,36,41)/t20?,24-,25-,27-/m0/s1
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n/an/a 733n/an/an/an/an/an/a



Iproteos S.L

US Patent


Assay Description
MMP-9: Recombinant MMP-9 expressed was obtained from Merck-Millipore (catalog number PF140-5UG, used in examples 1 to 9 and comparative examples) and...


US Patent US10414797 (2019)


BindingDB Entry DOI: 10.7270/Q2KS6TWP
More data for this
Ligand-Target Pair
Metalloproteinase inhibitor 2


(Cricetulus longicaudatus (Long-tailed dwarf hamste...)
BDBM413575
PNG
((2S)—N-[(1S)-1-[[(1S)-3-[(3,5-difluorobenzoyl...)
Show SMILES CCCC(CCC)C(=O)N1CCC[C@H]1C(=O)N(C)[C@@H](C(C)CC)C(=O)N[C@@H](CCNC(=O)c1cc(F)cc(F)c1)C(=O)NO
Show InChI InChI=1S/C31H47F2N5O6/c1-6-10-20(11-7-2)30(42)38-15-9-12-25(38)31(43)37(5)26(19(4)8-3)29(41)35-24(28(40)36-44)13-14-34-27(39)21-16-22(32)18-23(33)17-21/h16-20,24-26,44H,6-15H2,1-5H3,(H,34,39)(H,35,41)(H,36,40)/t19?,24-,25-,26-/m0/s1
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n/an/a 974n/an/an/an/an/an/a



Iproteos S.L

US Patent


Assay Description
MMP-2: Recombinant MMP-2 expressed in Chinese hamster ovary (CHO) cells was obtained from Merck-Millipore (catalog number PF023-5UG). DQ gelatin from...


US Patent US10414797 (2019)


BindingDB Entry DOI: 10.7270/Q2KS6TWP
More data for this
Ligand-Target Pair
Interstitial collagenase


(Homo sapiens (Human))
BDBM413584
PNG
((2S,4R)—N-[(1S)-1-[[(1S)-3-benzamido-1-(hydro...)
Show SMILES CCCCCC(=O)N1C[C@H](F)C[C@H]1C(=O)N(C)[C@@H](C(C)CC)C(=O)N[C@@H](CCNC(=O)c1ccccc1)C(=O)NO
Show InChI InChI=1S/C29H44FN5O6/c1-5-7-9-14-24(36)35-18-21(30)17-23(35)29(40)34(4)25(19(3)6-2)28(39)32-22(27(38)33-41)15-16-31-26(37)20-12-10-8-11-13-20/h8,10-13,19,21-23,25,41H,5-7,9,14-18H2,1-4H3,(H,31,37)(H,32,39)(H,33,38)/t19?,21-,22+,23+,25+/m1/s1
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n/an/a<1.00E+3n/an/an/an/an/an/a



Iproteos S.L

US Patent


Assay Description
MMP-1:MMP-1 peptide substrate was provided as a stock solution in DMSO (6 mM). For the assay, the substrate was diluted 1◊ reaction buffer to a conce...


US Patent US10414797 (2019)


BindingDB Entry DOI: 10.7270/Q2KS6TWP
More data for this
Ligand-Target Pair
Stromelysin-1


(Homo sapiens (Human))
BDBM413582
PNG
((2S)-1-[(2S)-2-[[(2S)-2-[butanoyl(methyl)amino]-3-...)
Show SMILES CCCC(=O)N(C)[C@@H](Cc1c[nH]c2ccccc12)C(=O)N(C)[C@@H](CC(C)C)C(=O)N1CCC[C@H]1C(=O)N(C)[C@@H](C(C)CC)C(=O)N[C@@H](CCNC(=O)c1cc(F)cc(F)c1)C(=O)NO
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n/an/a<1.00E+3n/an/an/an/an/an/a



Iproteos S.L

US Patent


Assay Description
MMP-3: Preparation of the MMP-3 for the activity assay: MMP-3 was provided as a stock solution (0.1 mg/mL). The enzyme was diluted in water to a fina...


US Patent US10414797 (2019)


BindingDB Entry DOI: 10.7270/Q2KS6TWP
More data for this
Ligand-Target Pair
Interstitial collagenase


(Homo sapiens (Human))
BDBM413568
PNG
((2S)-1-acetyl-N-[(1S)-1-[[(1S)-3-[(4-fluorobenzoyl...)
Show SMILES CCC(C)[C@H](N(C)C(=O)[C@@H]1CCCN1C(C)=O)C(=O)N[C@@H](CCNC(=O)c1ccc(F)cc1)C(=O)NO
Show InChI InChI=1S/C25H36FN5O6/c1-5-15(2)21(30(4)25(36)20-7-6-14-31(20)16(3)32)24(35)28-19(23(34)29-37)12-13-27-22(33)17-8-10-18(26)11-9-17/h8-11,15,19-21,37H,5-7,12-14H2,1-4H3,(H,27,33)(H,28,35)(H,29,34)/t15?,19-,20-,21-/m0/s1
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n/an/a<1.00E+3n/an/an/an/an/an/a



Iproteos S.L

US Patent


Assay Description
MMP-1:MMP-1 peptide substrate was provided as a stock solution in DMSO (6 mM). For the assay, the substrate was diluted 1◊ reaction buffer to a conce...


US Patent US10414797 (2019)


BindingDB Entry DOI: 10.7270/Q2KS6TWP
More data for this
Ligand-Target Pair
Stromelysin-1


(Homo sapiens (Human))
BDBM413584
PNG
((2S,4R)—N-[(1S)-1-[[(1S)-3-benzamido-1-(hydro...)
Show SMILES CCCCCC(=O)N1C[C@H](F)C[C@H]1C(=O)N(C)[C@@H](C(C)CC)C(=O)N[C@@H](CCNC(=O)c1ccccc1)C(=O)NO
Show InChI InChI=1S/C29H44FN5O6/c1-5-7-9-14-24(36)35-18-21(30)17-23(35)29(40)34(4)25(19(3)6-2)28(39)32-22(27(38)33-41)15-16-31-26(37)20-12-10-8-11-13-20/h8,10-13,19,21-23,25,41H,5-7,9,14-18H2,1-4H3,(H,31,37)(H,32,39)(H,33,38)/t19?,21-,22+,23+,25+/m1/s1
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n/an/a<1.00E+3n/an/an/an/an/an/a



Iproteos S.L

US Patent


Assay Description
MMP-3: Preparation of the MMP-3 for the activity assay: MMP-3 was provided as a stock solution (0.1 mg/mL). The enzyme was diluted in water to a fina...


US Patent US10414797 (2019)


BindingDB Entry DOI: 10.7270/Q2KS6TWP
More data for this
Ligand-Target Pair
Metalloproteinase inhibitor 2


(Cricetulus longicaudatus (Long-tailed dwarf hamste...)
BDBM413581
PNG
((2S)-1-[3-[acetyl(methyl)amino]propanoyl]-N-[(1S)-...)
Show SMILES CCC(C)[C@H](N(C)C(=O)[C@@H]1CCCN1C(=O)CCN(C)C(C)=O)C(=O)N[C@@H](CCNC(=O)c1cc(F)cc(F)c1)C(=O)NO
Show InChI InChI=1S/C29H42F2N6O7/c1-6-17(2)25(36(5)29(43)23-8-7-12-37(23)24(39)10-13-35(4)18(3)38)28(42)33-22(27(41)34-44)9-11-32-26(40)19-14-20(30)16-21(31)15-19/h14-17,22-23,25,44H,6-13H2,1-5H3,(H,32,40)(H,33,42)(H,34,41)/t17?,22-,23-,25-/m0/s1
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n/an/a 1.15E+3n/an/an/an/an/an/a



Iproteos S.L

US Patent


Assay Description
MMP-2: Recombinant MMP-2 expressed in Chinese hamster ovary (CHO) cells was obtained from Merck-Millipore (catalog number PF023-5UG). DQ gelatin from...


US Patent US10414797 (2019)


BindingDB Entry DOI: 10.7270/Q2KS6TWP
More data for this
Ligand-Target Pair
Matrix metalloproteinase-9


(Homo sapiens (Human))
BDBM413592
PNG
((2S)óN-[(1S)-1-[[(1S)-2-(hydroxyamino)-1-(1H-indol...)
Show SMILES CCCCCCCCCCCCCC(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NO
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n/an/a 1.20E+3n/an/an/an/an/an/a



Iproteos S.L

US Patent


Assay Description
MMP-9: Recombinant MMP-9 expressed was obtained from Merck-Millipore (catalog number PF140-5UG, used in examples 1 to 9 and comparative examples) and...


US Patent US10414797 (2019)


BindingDB Entry DOI: 10.7270/Q2KS6TWP
More data for this
Ligand-Target Pair
Matrix metalloproteinase-9


(Homo sapiens (Human))
BDBM413568
PNG
((2S)-1-acetyl-N-[(1S)-1-[[(1S)-3-[(4-fluorobenzoyl...)
Show SMILES CCC(C)[C@H](N(C)C(=O)[C@@H]1CCCN1C(C)=O)C(=O)N[C@@H](CCNC(=O)c1ccc(F)cc1)C(=O)NO
Show InChI InChI=1S/C25H36FN5O6/c1-5-15(2)21(30(4)25(36)20-7-6-14-31(20)16(3)32)24(35)28-19(23(34)29-37)12-13-27-22(33)17-8-10-18(26)11-9-17/h8-11,15,19-21,37H,5-7,12-14H2,1-4H3,(H,27,33)(H,28,35)(H,29,34)/t15?,19-,20-,21-/m0/s1
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n/an/a 1.26E+3n/an/an/an/an/an/a



Iproteos S.L

US Patent


Assay Description
MMP-9: Recombinant MMP-9 expressed was obtained from Merck-Millipore (catalog number PF140-5UG, used in examples 1 to 9 and comparative examples) and...


US Patent US10414797 (2019)


BindingDB Entry DOI: 10.7270/Q2KS6TWP
More data for this
Ligand-Target Pair
Stromelysin-1


(Homo sapiens (Human))
BDBM413585
PNG
((2S)-2-[[(2S)-1-acetylpyrrolidine-2-carbonyl)amino...)
Show SMILES CC(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NO
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n/an/a 3.10E+3n/an/an/an/an/an/a



Iproteos S.L

US Patent


Assay Description
MMP-3: Preparation of the MMP-3 for the activity assay: MMP-3 was provided as a stock solution (0.1 mg/mL). The enzyme was diluted in water to a fina...


US Patent US10414797 (2019)


BindingDB Entry DOI: 10.7270/Q2KS6TWP
More data for this
Ligand-Target Pair
Metalloproteinase inhibitor 2


(Cricetulus longicaudatus (Long-tailed dwarf hamste...)
BDBM413592
PNG
((2S)óN-[(1S)-1-[[(1S)-2-(hydroxyamino)-1-(1H-indol...)
Show SMILES CCCCCCCCCCCCCC(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NO
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n/an/a 4.80E+3n/an/an/an/an/an/a



Iproteos S.L

US Patent


Assay Description
MMP-2: Recombinant MMP-2 expressed in Chinese hamster ovary (CHO) cells was obtained from Merck-Millipore (catalog number PF023-5UG). DQ gelatin from...


US Patent US10414797 (2019)


BindingDB Entry DOI: 10.7270/Q2KS6TWP
More data for this
Ligand-Target Pair
Interstitial collagenase


(Homo sapiens (Human))
BDBM413585
PNG
((2S)-2-[[(2S)-1-acetylpyrrolidine-2-carbonyl)amino...)
Show SMILES CC(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NO
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n/an/a 6.10E+3n/an/an/an/an/an/a



Iproteos S.L

US Patent


Assay Description
MMP-1:MMP-1 peptide substrate was provided as a stock solution in DMSO (6 mM). For the assay, the substrate was diluted 1◊ reaction buffer to a conce...


US Patent US10414797 (2019)


BindingDB Entry DOI: 10.7270/Q2KS6TWP
More data for this
Ligand-Target Pair
Matrix metalloproteinase-9


(Homo sapiens (Human))
BDBM413591
PNG
(US10414797, Comparative Example 21 | US10414797, E...)
Show SMILES CCC(C)[C@H](N(C)C(=O)[C@@H]1CCCN1C(C)=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NO
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n/an/a 1.60E+4n/an/an/an/an/an/a



Iproteos S.L

US Patent


Assay Description
MMP-9: Recombinant MMP-9 expressed was obtained from Merck-Millipore (catalog number PF140-5UG, used in examples 1 to 9 and comparative examples) and...


US Patent US10414797 (2019)


BindingDB Entry DOI: 10.7270/Q2KS6TWP
More data for this
Ligand-Target Pair
Matrix metalloproteinase-9


(Homo sapiens (Human))
BDBM413590
PNG
((2S)-2-[[(2S)-1-acetylpyrrolidine-2-carbonyl]-meth...)
Show SMILES CN([C@@H](CCC(N)=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NO)C(=O)[C@@H]1CCCN1C(C)=O
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n/an/a 2.20E+4n/an/an/an/an/an/a



Iproteos S.L

US Patent


Assay Description
MMP-9: Recombinant MMP-9 expressed was obtained from Merck-Millipore (catalog number PF140-5UG, used in examples 1 to 9 and comparative examples) and...


US Patent US10414797 (2019)


BindingDB Entry DOI: 10.7270/Q2KS6TWP
More data for this
Ligand-Target Pair
Metalloproteinase inhibitor 2


(Cricetulus longicaudatus (Long-tailed dwarf hamste...)
BDBM413590
PNG
((2S)-2-[[(2S)-1-acetylpyrrolidine-2-carbonyl]-meth...)
Show SMILES CN([C@@H](CCC(N)=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NO)C(=O)[C@@H]1CCCN1C(C)=O
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n/an/a 5.30E+4n/an/an/an/an/an/a



Iproteos S.L

US Patent


Assay Description
MMP-2: Recombinant MMP-2 expressed in Chinese hamster ovary (CHO) cells was obtained from Merck-Millipore (catalog number PF023-5UG). DQ gelatin from...


US Patent US10414797 (2019)


BindingDB Entry DOI: 10.7270/Q2KS6TWP
More data for this
Ligand-Target Pair
Metalloproteinase inhibitor 2


(Cricetulus longicaudatus (Long-tailed dwarf hamste...)
BDBM413585
PNG
((2S)-2-[[(2S)-1-acetylpyrrolidine-2-carbonyl)amino...)
Show SMILES CC(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NO
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n/an/a 1.10E+5n/an/an/an/an/an/a



Iproteos S.L

US Patent


Assay Description
MMP-2: Recombinant MMP-2 expressed in Chinese hamster ovary (CHO) cells was obtained from Merck-Millipore (catalog number PF023-5UG). DQ gelatin from...


US Patent US10414797 (2019)


BindingDB Entry DOI: 10.7270/Q2KS6TWP
More data for this
Ligand-Target Pair
Metalloproteinase inhibitor 2


(Cricetulus longicaudatus (Long-tailed dwarf hamste...)
BDBM413591
PNG
(US10414797, Comparative Example 21 | US10414797, E...)
Show SMILES CCC(C)[C@H](N(C)C(=O)[C@@H]1CCCN1C(C)=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NO
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n/an/a 1.10E+5n/an/an/an/an/an/a



Iproteos S.L

US Patent


Assay Description
MMP-2: Recombinant MMP-2 expressed in Chinese hamster ovary (CHO) cells was obtained from Merck-Millipore (catalog number PF023-5UG). DQ gelatin from...


US Patent US10414797 (2019)


BindingDB Entry DOI: 10.7270/Q2KS6TWP
More data for this
Ligand-Target Pair
Matrix metalloproteinase-9


(Homo sapiens (Human))
BDBM413586
PNG
((2 S)-2-acetamido-N-[(1S)-2-[[(1S)-1-(hydroxycarba...)
Show SMILES CCC(C)[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(C)=O)C(=O)NO
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n/an/a 2.40E+5n/an/an/an/an/an/a



Iproteos S.L

US Patent


Assay Description
MMP-9: Recombinant MMP-9 expressed was obtained from Merck-Millipore (catalog number PF140-5UG, used in examples 1 to 9 and comparative examples) and...


US Patent US10414797 (2019)


BindingDB Entry DOI: 10.7270/Q2KS6TWP
More data for this
Ligand-Target Pair
Metalloproteinase inhibitor 2


(Cricetulus longicaudatus (Long-tailed dwarf hamste...)
BDBM413586
PNG
((2 S)-2-acetamido-N-[(1S)-2-[[(1S)-1-(hydroxycarba...)
Show SMILES CCC(C)[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(C)=O)C(=O)NO
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n/an/a 7.10E+5n/an/an/an/an/an/a



Iproteos S.L

US Patent


Assay Description
MMP-2: Recombinant MMP-2 expressed in Chinese hamster ovary (CHO) cells was obtained from Merck-Millipore (catalog number PF023-5UG). DQ gelatin from...


US Patent US10414797 (2019)


BindingDB Entry DOI: 10.7270/Q2KS6TWP
More data for this
Ligand-Target Pair
Matrix metalloproteinase 7


(Homo sapiens (Human))
BDBM413584
PNG
((2S,4R)—N-[(1S)-1-[[(1S)-3-benzamido-1-(hydro...)
Show SMILES CCCCCC(=O)N1C[C@H](F)C[C@H]1C(=O)N(C)[C@@H](C(C)CC)C(=O)N[C@@H](CCNC(=O)c1ccccc1)C(=O)NO
Show InChI InChI=1S/C29H44FN5O6/c1-5-7-9-14-24(36)35-18-21(30)17-23(35)29(40)34(4)25(19(3)6-2)28(39)32-22(27(38)33-41)15-16-31-26(37)20-12-10-8-11-13-20/h8,10-13,19,21-23,25,41H,5-7,9,14-18H2,1-4H3,(H,31,37)(H,32,39)(H,33,38)/t19?,21-,22+,23+,25+/m1/s1
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n/an/a 1.00E+6n/an/an/an/an/an/a



Iproteos S.L

US Patent


Assay Description
MMP-7: Recombinant MMP-7 expressed in E. Coli was obtained from Merck-Millipore (catalog number 44270). Mca-PLGL-Dpa-AR-NH2 (fluorogenic peptide subs...


US Patent US10414797 (2019)


BindingDB Entry DOI: 10.7270/Q2KS6TWP
More data for this
Ligand-Target Pair
Matrix metalloproteinase-9


(Homo sapiens (Human))
BDBM413593
PNG
((2S)-2-[[(SS)-1-hexanoylpyrrolidine-2-carbonyl)-me...)
Show SMILES CCCCCC(=O)N1CCC[C@H]1C(=O)N(C)[C@@H](CCC(N)=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NO
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n/an/a>1.00E+6n/an/an/an/an/an/a



Iproteos S.L

US Patent


Assay Description
MMP-9: Recombinant MMP-9 expressed was obtained from Merck-Millipore (catalog number PF140-5UG, used in examples 1 to 9 and comparative examples) and...


US Patent US10414797 (2019)


BindingDB Entry DOI: 10.7270/Q2KS6TWP
More data for this
Ligand-Target Pair
Metalloproteinase inhibitor 2


(Cricetulus longicaudatus (Long-tailed dwarf hamste...)
BDBM413587
PNG
((2S)-1-[(2S)-2-acetamido-5-amino-5-oxo-pentanoyl]-...)
Show SMILES CCC(C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCC(N)=O)NC(C)=O)C(=O)NO
Show InChI InChI=1S/C18H31N5O6/c1-4-10(2)15(17(27)22-29)21-16(26)13-6-5-9-23(13)18(28)12(20-11(3)24)7-8-14(19)25/h10,12-13,15,29H,4-9H2,1-3H3,(H2,19,25)(H,20,24)(H,21,26)(H,22,27)/t10?,12-,13-,15-/m0/s1
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n/an/a>2.00E+6n/an/an/an/an/an/a



Iproteos S.L

US Patent


Assay Description
MMP-2: Recombinant MMP-2 expressed in Chinese hamster ovary (CHO) cells was obtained from Merck-Millipore (catalog number PF023-5UG). DQ gelatin from...


US Patent US10414797 (2019)


BindingDB Entry DOI: 10.7270/Q2KS6TWP
More data for this
Ligand-Target Pair
Interstitial collagenase


(Homo sapiens (Human))
BDBM413590
PNG
((2S)-2-[[(2S)-1-acetylpyrrolidine-2-carbonyl]-meth...)
Show SMILES CN([C@@H](CCC(N)=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NO)C(=O)[C@@H]1CCCN1C(C)=O
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n/an/a>2.00E+6n/an/an/an/an/an/a



Iproteos S.L

US Patent


Assay Description
MMP-1:MMP-1 peptide substrate was provided as a stock solution in DMSO (6 mM). For the assay, the substrate was diluted 1◊ reaction buffer to a conce...


US Patent US10414797 (2019)


BindingDB Entry DOI: 10.7270/Q2KS6TWP
More data for this
Ligand-Target Pair
Matrix metalloproteinase 7


(Homo sapiens (Human))
BDBM413585
PNG
((2S)-2-[[(2S)-1-acetylpyrrolidine-2-carbonyl)amino...)
Show SMILES CC(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NO
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n/an/a>2.00E+6n/an/an/an/an/an/a



Iproteos S.L

US Patent


Assay Description
MMP-7: Recombinant MMP-7 expressed in E. Coli was obtained from Merck-Millipore (catalog number 44270). Mca-PLGL-Dpa-AR-NH2 (fluorogenic peptide subs...


US Patent US10414797 (2019)


BindingDB Entry DOI: 10.7270/Q2KS6TWP
More data for this
Ligand-Target Pair
Metalloproteinase inhibitor 2


(Cricetulus longicaudatus (Long-tailed dwarf hamste...)
BDBM413593
PNG
((2S)-2-[[(SS)-1-hexanoylpyrrolidine-2-carbonyl)-me...)
Show SMILES CCCCCC(=O)N1CCC[C@H]1C(=O)N(C)[C@@H](CCC(N)=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NO
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n/an/a>2.00E+6n/an/an/an/an/an/a



Iproteos S.L

US Patent


Assay Description
MMP-2: Recombinant MMP-2 expressed in Chinese hamster ovary (CHO) cells was obtained from Merck-Millipore (catalog number PF023-5UG). DQ gelatin from...


US Patent US10414797 (2019)


BindingDB Entry DOI: 10.7270/Q2KS6TWP
More data for this
Ligand-Target Pair
Matrix metalloproteinase-9


(Homo sapiens (Human))
BDBM413587
PNG
((2S)-1-[(2S)-2-acetamido-5-amino-5-oxo-pentanoyl]-...)
Show SMILES CCC(C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCC(N)=O)NC(C)=O)C(=O)NO
Show InChI InChI=1S/C18H31N5O6/c1-4-10(2)15(17(27)22-29)21-16(26)13-6-5-9-23(13)18(28)12(20-11(3)24)7-8-14(19)25/h10,12-13,15,29H,4-9H2,1-3H3,(H2,19,25)(H,20,24)(H,21,26)(H,22,27)/t10?,12-,13-,15-/m0/s1
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n/an/a>2.00E+6n/an/an/an/an/an/a



Iproteos S.L

US Patent


Assay Description
MMP-9: Recombinant MMP-9 expressed was obtained from Merck-Millipore (catalog number PF140-5UG, used in examples 1 to 9 and comparative examples) and...


US Patent US10414797 (2019)


BindingDB Entry DOI: 10.7270/Q2KS6TWP
More data for this
Ligand-Target Pair
Stromelysin-1


(Homo sapiens (Human))
BDBM413590
PNG
((2S)-2-[[(2S)-1-acetylpyrrolidine-2-carbonyl]-meth...)
Show SMILES CN([C@@H](CCC(N)=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NO)C(=O)[C@@H]1CCCN1C(C)=O
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n/an/a>2.00E+6n/an/an/an/an/an/a



Iproteos S.L

US Patent


Assay Description
MMP-3: Preparation of the MMP-3 for the activity assay: MMP-3 was provided as a stock solution (0.1 mg/mL). The enzyme was diluted in water to a fina...


US Patent US10414797 (2019)


BindingDB Entry DOI: 10.7270/Q2KS6TWP
More data for this
Ligand-Target Pair
Matrix metalloproteinase 7


(Homo sapiens (Human))
BDBM413590
PNG
((2S)-2-[[(2S)-1-acetylpyrrolidine-2-carbonyl]-meth...)
Show SMILES CN([C@@H](CCC(N)=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NO)C(=O)[C@@H]1CCCN1C(C)=O
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n/an/a>2.00E+6n/an/an/an/an/an/a



Iproteos S.L

US Patent


Assay Description
MMP-7: Recombinant MMP-7 expressed in E. Coli was obtained from Merck-Millipore (catalog number 44270). Mca-PLGL-Dpa-AR-NH2 (fluorogenic peptide subs...


US Patent US10414797 (2019)


BindingDB Entry DOI: 10.7270/Q2KS6TWP
More data for this
Ligand-Target Pair
Stromelysin-1


(Homo sapiens (Human))
BDBM413576
PNG
((2S)—N-[(1S)-1-[[(1S)-3-[(3,5-difluorobenzoyl...)
Show SMILES CCC(C)[C@H](N(C)C(=O)[C@@H]1CCCN1C(=O)CCCOc1ccccc1)C(=O)N[C@@H](CCNC(=O)c1cc(F)cc(F)c1)C(=O)NO
Show InChI InChI=1S/C33H43F2N5O7/c1-4-21(2)29(32(44)37-26(31(43)38-46)14-15-36-30(42)22-18-23(34)20-24(35)19-22)39(3)33(45)27-12-8-16-40(27)28(41)13-9-17-47-25-10-6-5-7-11-25/h5-7,10-11,18-21,26-27,29,46H,4,8-9,12-17H2,1-3H3,(H,36,42)(H,37,44)(H,38,43)/t21?,26-,27-,29-/m0/s1
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n/an/a 3.20E+6n/an/an/an/an/an/a



Iproteos S.L

US Patent


Assay Description
MMP-3: Preparation of the MMP-3 for the activity assay: MMP-3 was provided as a stock solution (0.1 mg/mL). The enzyme was diluted in water to a fina...


US Patent US10414797 (2019)


BindingDB Entry DOI: 10.7270/Q2KS6TWP
More data for this
Ligand-Target Pair
Matrix metalloproteinase 7


(Homo sapiens (Human))
BDBM413572
PNG
((2S)—N-[(1S)-1-[[(1S)-3-[(3,5-difluorobenzoyl...)
Show SMILES CCC(C)[C@H](N(C)C(=O)[C@@H]1CCCN1C(=O)CC(C)C)C(=O)N[C@@H](CCNC(=O)c1cc(F)cc(F)c1)C(=O)NO
Show InChI InChI=1S/C28H41F2N5O6/c1-6-17(4)24(34(5)28(40)22-8-7-11-35(22)23(36)12-16(2)3)27(39)32-21(26(38)33-41)9-10-31-25(37)18-13-19(29)15-20(30)14-18/h13-17,21-22,24,41H,6-12H2,1-5H3,(H,31,37)(H,32,39)(H,33,38)/t17?,21-,22-,24-/m0/s1
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n/an/a 3.48E+6n/an/an/an/an/an/a



Iproteos S.L

US Patent


Assay Description
MMP-7: Recombinant MMP-7 expressed in E. Coli was obtained from Merck-Millipore (catalog number 44270). Mca-PLGL-Dpa-AR-NH2 (fluorogenic peptide subs...


US Patent US10414797 (2019)


BindingDB Entry DOI: 10.7270/Q2KS6TWP
More data for this
Ligand-Target Pair
Matrix metalloproteinase-9


(Homo sapiens (Human))
BDBM413585
PNG
((2S)-2-[[(2S)-1-acetylpyrrolidine-2-carbonyl)amino...)
Show SMILES CC(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NO
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n/an/a 3.50E+6n/an/an/an/an/an/a



Iproteos S.L

US Patent


Assay Description
MMP-9: Recombinant MMP-9 expressed was obtained from Merck-Millipore (catalog number PF140-5UG, used in examples 1 to 9 and comparative examples) and...


US Patent US10414797 (2019)


BindingDB Entry DOI: 10.7270/Q2KS6TWP
More data for this
Ligand-Target Pair
Interstitial collagenase


(Homo sapiens (Human))
BDBM413575
PNG
((2S)—N-[(1S)-1-[[(1S)-3-[(3,5-difluorobenzoyl...)
Show SMILES CCCC(CCC)C(=O)N1CCC[C@H]1C(=O)N(C)[C@@H](C(C)CC)C(=O)N[C@@H](CCNC(=O)c1cc(F)cc(F)c1)C(=O)NO
Show InChI InChI=1S/C31H47F2N5O6/c1-6-10-20(11-7-2)30(42)38-15-9-12-25(38)31(43)37(5)26(19(4)8-3)29(41)35-24(28(40)36-44)13-14-34-27(39)21-16-22(32)18-23(33)17-21/h16-20,24-26,44H,6-15H2,1-5H3,(H,34,39)(H,35,41)(H,36,40)/t19?,24-,25-,26-/m0/s1
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n/an/a 3.65E+6n/an/an/an/an/an/a



Iproteos S.L

US Patent


Assay Description
MMP-1:MMP-1 peptide substrate was provided as a stock solution in DMSO (6 mM). For the assay, the substrate was diluted 1◊ reaction buffer to a conce...


US Patent US10414797 (2019)


BindingDB Entry DOI: 10.7270/Q2KS6TWP
More data for this
Ligand-Target Pair
Stromelysin-1


(Homo sapiens (Human))
BDBM413575
PNG
((2S)—N-[(1S)-1-[[(1S)-3-[(3,5-difluorobenzoyl...)
Show SMILES CCCC(CCC)C(=O)N1CCC[C@H]1C(=O)N(C)[C@@H](C(C)CC)C(=O)N[C@@H](CCNC(=O)c1cc(F)cc(F)c1)C(=O)NO
Show InChI InChI=1S/C31H47F2N5O6/c1-6-10-20(11-7-2)30(42)38-15-9-12-25(38)31(43)37(5)26(19(4)8-3)29(41)35-24(28(40)36-44)13-14-34-27(39)21-16-22(32)18-23(33)17-21/h16-20,24-26,44H,6-15H2,1-5H3,(H,34,39)(H,35,41)(H,36,40)/t19?,24-,25-,26-/m0/s1
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n/an/a 3.81E+6n/an/an/an/an/an/a



Iproteos S.L

US Patent


Assay Description
MMP-3: Preparation of the MMP-3 for the activity assay: MMP-3 was provided as a stock solution (0.1 mg/mL). The enzyme was diluted in water to a fina...


US Patent US10414797 (2019)


BindingDB Entry DOI: 10.7270/Q2KS6TWP
More data for this
Ligand-Target Pair
Matrix metalloproteinase 7


(Homo sapiens (Human))
BDBM413575
PNG
((2S)—N-[(1S)-1-[[(1S)-3-[(3,5-difluorobenzoyl...)
Show SMILES CCCC(CCC)C(=O)N1CCC[C@H]1C(=O)N(C)[C@@H](C(C)CC)C(=O)N[C@@H](CCNC(=O)c1cc(F)cc(F)c1)C(=O)NO
Show InChI InChI=1S/C31H47F2N5O6/c1-6-10-20(11-7-2)30(42)38-15-9-12-25(38)31(43)37(5)26(19(4)8-3)29(41)35-24(28(40)36-44)13-14-34-27(39)21-16-22(32)18-23(33)17-21/h16-20,24-26,44H,6-15H2,1-5H3,(H,34,39)(H,35,41)(H,36,40)/t19?,24-,25-,26-/m0/s1
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n/an/a 4.10E+6n/an/an/an/an/an/a



Iproteos S.L

US Patent


Assay Description
MMP-7: Recombinant MMP-7 expressed in E. Coli was obtained from Merck-Millipore (catalog number 44270). Mca-PLGL-Dpa-AR-NH2 (fluorogenic peptide subs...


US Patent US10414797 (2019)


BindingDB Entry DOI: 10.7270/Q2KS6TWP
More data for this
Ligand-Target Pair
Matrix metalloproteinase 7


(Homo sapiens (Human))
BDBM413571
PNG
((2S)-1-butanoyl-N-[(1S)-1-[[(1S)-3-[(3,5-difluorob...)
Show SMILES CCCC(=O)N1CCC[C@H]1C(=O)N(C)[C@@H](C(C)CC)C(=O)N[C@@H](CCNC(=O)c1cc(F)cc(F)c1)C(=O)NO
Show InChI InChI=1S/C27H39F2N5O6/c1-5-8-22(35)34-12-7-9-21(34)27(39)33(4)23(16(3)6-2)26(38)31-20(25(37)32-40)10-11-30-24(36)17-13-18(28)15-19(29)14-17/h13-16,20-21,23,40H,5-12H2,1-4H3,(H,30,36)(H,31,38)(H,32,37)/t16?,20-,21-,23-/m0/s1
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n/an/a 4.42E+6n/an/an/an/an/an/a



Iproteos S.L

US Patent


Assay Description
MMP-7: Recombinant MMP-7 expressed in E. Coli was obtained from Merck-Millipore (catalog number 44270). Mca-PLGL-Dpa-AR-NH2 (fluorogenic peptide subs...


US Patent US10414797 (2019)


BindingDB Entry DOI: 10.7270/Q2KS6TWP
More data for this
Ligand-Target Pair
Interstitial collagenase


(Homo sapiens (Human))
BDBM413571
PNG
((2S)-1-butanoyl-N-[(1S)-1-[[(1S)-3-[(3,5-difluorob...)
Show SMILES CCCC(=O)N1CCC[C@H]1C(=O)N(C)[C@@H](C(C)CC)C(=O)N[C@@H](CCNC(=O)c1cc(F)cc(F)c1)C(=O)NO
Show InChI InChI=1S/C27H39F2N5O6/c1-5-8-22(35)34-12-7-9-21(34)27(39)33(4)23(16(3)6-2)26(38)31-20(25(37)32-40)10-11-30-24(36)17-13-18(28)15-19(29)14-17/h13-16,20-21,23,40H,5-12H2,1-4H3,(H,30,36)(H,31,38)(H,32,37)/t16?,20-,21-,23-/m0/s1
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n/an/a 4.73E+6n/an/an/an/an/an/a



Iproteos S.L

US Patent


Assay Description
MMP-1:MMP-1 peptide substrate was provided as a stock solution in DMSO (6 mM). For the assay, the substrate was diluted 1◊ reaction buffer to a conce...


US Patent US10414797 (2019)


BindingDB Entry DOI: 10.7270/Q2KS6TWP
More data for this
Ligand-Target Pair
Interstitial collagenase


(Homo sapiens (Human))
BDBM413569
PNG
((2S)-1-acetyl-N-[(1S)-1-[[(1S)-3-[(3,5-difluoroben...)
Show SMILES CCC(C)[C@H](N(C)C(=O)[C@@H]1CCCN1C(C)=O)C(=O)N[C@@H](CCNC(=O)c1cc(F)cc(F)c1)C(=O)NO
Show InChI InChI=1S/C25H35F2N5O6/c1-5-14(2)21(31(4)25(37)20-7-6-10-32(20)15(3)33)24(36)29-19(23(35)30-38)8-9-28-22(34)16-11-17(26)13-18(27)12-16/h11-14,19-21,38H,5-10H2,1-4H3,(H,28,34)(H,29,36)(H,30,35)/t14?,19-,20-,21-/m0/s1
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n/an/a 4.94E+6n/an/an/an/an/an/a



Iproteos S.L

US Patent


Assay Description
MMP-1:MMP-1 peptide substrate was provided as a stock solution in DMSO (6 mM). For the assay, the substrate was diluted 1◊ reaction buffer to a conce...


US Patent US10414797 (2019)


BindingDB Entry DOI: 10.7270/Q2KS6TWP
More data for this
Ligand-Target Pair
Interstitial collagenase


(Homo sapiens (Human))
BDBM413582
PNG
((2S)-1-[(2S)-2-[[(2S)-2-[butanoyl(methyl)amino]-3-...)
Show SMILES CCCC(=O)N(C)[C@@H](Cc1c[nH]c2ccccc12)C(=O)N(C)[C@@H](CC(C)C)C(=O)N1CCC[C@H]1C(=O)N(C)[C@@H](C(C)CC)C(=O)N[C@@H](CCNC(=O)c1cc(F)cc(F)c1)C(=O)NO
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n/an/a 6.07E+6n/an/an/an/an/an/a



Iproteos S.L

US Patent


Assay Description
MMP-1:MMP-1 peptide substrate was provided as a stock solution in DMSO (6 mM). For the assay, the substrate was diluted 1◊ reaction buffer to a conce...


US Patent US10414797 (2019)


BindingDB Entry DOI: 10.7270/Q2KS6TWP
More data for this
Ligand-Target Pair
Interstitial collagenase


(Homo sapiens (Human))
BDBM413577
PNG
((2S)—N-[(1S)-1-[[(1S)-3-[(3,5-difluorobenzoyl...)
Show SMILES CCC(C)[C@H](N(C)C(=O)[C@@H]1CC(F)(F)CN1C(=O)CCCOc1ccccc1)C(=O)N[C@@H](CCNC(=O)c1cc(F)cc(F)c1)C(=O)NO
Show InChI InChI=1S/C33H41F4N5O7/c1-4-20(2)28(31(46)39-25(30(45)40-48)12-13-38-29(44)21-15-22(34)17-23(35)16-21)41(3)32(47)26-18-33(36,37)19-42(26)27(43)11-8-14-49-24-9-6-5-7-10-24/h5-7,9-10,15-17,20,25-26,28,48H,4,8,11-14,18-19H2,1-3H3,(H,38,44)(H,39,46)(H,40,45)/t20?,25-,26-,28-/m0/s1
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n/an/a 6.61E+6n/an/an/an/an/an/a



Iproteos S.L

US Patent


Assay Description
MMP-1:MMP-1 peptide substrate was provided as a stock solution in DMSO (6 mM). For the assay, the substrate was diluted 1◊ reaction buffer to a conce...


US Patent US10414797 (2019)


BindingDB Entry DOI: 10.7270/Q2KS6TWP
More data for this
Ligand-Target Pair
Matrix metalloproteinase 7


(Homo sapiens (Human))
BDBM413570
PNG
((2S)—N-[(1S)-1-[[(1S)-3-[(3,5-difluorobenzoyl...)
Show SMILES CCCCCC(=O)N1CCC[C@H]1C(=O)N(C)[C@@H](C(C)CC)C(=O)N[C@@H](CCNC(=O)c1cc(F)cc(F)c1)C(=O)NO
Show InChI InChI=1S/C29H43F2N5O6/c1-5-7-8-11-24(37)36-14-9-10-23(36)29(41)35(4)25(18(3)6-2)28(40)33-22(27(39)34-42)12-13-32-26(38)19-15-20(30)17-21(31)16-19/h15-18,22-23,25,42H,5-14H2,1-4H3,(H,32,38)(H,33,40)(H,34,39)/t18?,22-,23-,25-/m0/s1
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n/an/a 6.61E+6n/an/an/an/an/an/a



Iproteos S.L

US Patent


Assay Description
MMP-7: Recombinant MMP-7 expressed in E. Coli was obtained from Merck-Millipore (catalog number 44270). Mca-PLGL-Dpa-AR-NH2 (fluorogenic peptide subs...


US Patent US10414797 (2019)


BindingDB Entry DOI: 10.7270/Q2KS6TWP
More data for this
Ligand-Target Pair
Interstitial collagenase


(Homo sapiens (Human))
BDBM413572
PNG
((2S)—N-[(1S)-1-[[(1S)-3-[(3,5-difluorobenzoyl...)
Show SMILES CCC(C)[C@H](N(C)C(=O)[C@@H]1CCCN1C(=O)CC(C)C)C(=O)N[C@@H](CCNC(=O)c1cc(F)cc(F)c1)C(=O)NO
Show InChI InChI=1S/C28H41F2N5O6/c1-6-17(4)24(34(5)28(40)22-8-7-11-35(22)23(36)12-16(2)3)27(39)32-21(26(38)33-41)9-10-31-25(37)18-13-19(29)15-20(30)14-18/h13-17,21-22,24,41H,6-12H2,1-5H3,(H,31,37)(H,32,39)(H,33,38)/t17?,21-,22-,24-/m0/s1
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n/an/a 6.68E+6n/an/an/an/an/an/a



Iproteos S.L

US Patent


Assay Description
MMP-1:MMP-1 peptide substrate was provided as a stock solution in DMSO (6 mM). For the assay, the substrate was diluted 1◊ reaction buffer to a conce...


US Patent US10414797 (2019)


BindingDB Entry DOI: 10.7270/Q2KS6TWP
More data for this
Ligand-Target Pair
Interstitial collagenase


(Homo sapiens (Human))
BDBM413570
PNG
((2S)—N-[(1S)-1-[[(1S)-3-[(3,5-difluorobenzoyl...)
Show SMILES CCCCCC(=O)N1CCC[C@H]1C(=O)N(C)[C@@H](C(C)CC)C(=O)N[C@@H](CCNC(=O)c1cc(F)cc(F)c1)C(=O)NO
Show InChI InChI=1S/C29H43F2N5O6/c1-5-7-8-11-24(37)36-14-9-10-23(36)29(41)35(4)25(18(3)6-2)28(40)33-22(27(39)34-42)12-13-32-26(38)19-15-20(30)17-21(31)16-19/h15-18,22-23,25,42H,5-14H2,1-4H3,(H,32,38)(H,33,40)(H,34,39)/t18?,22-,23-,25-/m0/s1
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n/an/a 6.82E+6n/an/an/an/an/an/a



Iproteos S.L

US Patent


Assay Description
MMP-1:MMP-1 peptide substrate was provided as a stock solution in DMSO (6 mM). For the assay, the substrate was diluted 1◊ reaction buffer to a conce...


US Patent US10414797 (2019)


BindingDB Entry DOI: 10.7270/Q2KS6TWP
More data for this
Ligand-Target Pair
Matrix metalloproteinase 7


(Homo sapiens (Human))
BDBM413574
PNG
((2S)—N-[(1S)-1-[[(1S)-3-[(3,5-difluorobenzoyl...)
Show SMILES CCCCCC(=O)N1CC(F)(F)C[C@H]1C(=O)N(C)[C@@H](C(C)CC)C(=O)N[C@@H](CCNC(=O)c1cc(F)cc(F)c1)C(=O)NO
Show InChI InChI=1S/C29H41F4N5O6/c1-5-7-8-9-23(39)38-16-29(32,33)15-22(38)28(43)37(4)24(17(3)6-2)27(42)35-21(26(41)36-44)10-11-34-25(40)18-12-19(30)14-20(31)13-18/h12-14,17,21-22,24,44H,5-11,15-16H2,1-4H3,(H,34,40)(H,35,42)(H,36,41)/t17?,21-,22-,24-/m0/s1
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n/an/a 7.71E+6n/an/an/an/an/an/a



Iproteos S.L

US Patent


Assay Description
MMP-7: Recombinant MMP-7 expressed in E. Coli was obtained from Merck-Millipore (catalog number 44270). Mca-PLGL-Dpa-AR-NH2 (fluorogenic peptide subs...


US Patent US10414797 (2019)


BindingDB Entry DOI: 10.7270/Q2KS6TWP
More data for this
Ligand-Target Pair
Matrix metalloproteinase 7


(Homo sapiens (Human))
BDBM413577
PNG
((2S)—N-[(1S)-1-[[(1S)-3-[(3,5-difluorobenzoyl...)
Show SMILES CCC(C)[C@H](N(C)C(=O)[C@@H]1CC(F)(F)CN1C(=O)CCCOc1ccccc1)C(=O)N[C@@H](CCNC(=O)c1cc(F)cc(F)c1)C(=O)NO
Show InChI InChI=1S/C33H41F4N5O7/c1-4-20(2)28(31(46)39-25(30(45)40-48)12-13-38-29(44)21-15-22(34)17-23(35)16-21)41(3)32(47)26-18-33(36,37)19-42(26)27(43)11-8-14-49-24-9-6-5-7-10-24/h5-7,9-10,15-17,20,25-26,28,48H,4,8,11-14,18-19H2,1-3H3,(H,38,44)(H,39,46)(H,40,45)/t20?,25-,26-,28-/m0/s1
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n/an/a 8.08E+6n/an/an/an/an/an/a



Iproteos S.L

US Patent


Assay Description
MMP-7: Recombinant MMP-7 expressed in E. Coli was obtained from Merck-Millipore (catalog number 44270). Mca-PLGL-Dpa-AR-NH2 (fluorogenic peptide subs...


US Patent US10414797 (2019)


BindingDB Entry DOI: 10.7270/Q2KS6TWP
More data for this
Ligand-Target Pair
Interstitial collagenase


(Homo sapiens (Human))
BDBM413579
PNG
((2 S)-1-[(2S)-2-[acetyl(methyl)amino]-3-phenyl-pro...)
Show SMILES CCC(C)[C@H](N(C)C(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccccc1)N(C)C(C)=O)C(=O)N[C@@H](CCNC(=O)c1cc(F)cc(F)c1)C(=O)NO
Show InChI InChI=1S/C35H46F2N6O7/c1-6-21(2)30(33(47)39-27(32(46)40-50)14-15-38-31(45)24-18-25(36)20-26(37)19-24)42(5)34(48)28-13-10-16-43(28)35(49)29(41(4)22(3)44)17-23-11-8-7-9-12-23/h7-9,11-12,18-21,27-30,50H,6,10,13-17H2,1-5H3,(H,38,45)(H,39,47)(H,40,46)/t21?,27-,28-,29-,30-/m0/s1
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n/an/a 9.13E+6n/an/an/an/an/an/a



Iproteos S.L

US Patent


Assay Description
MMP-1:MMP-1 peptide substrate was provided as a stock solution in DMSO (6 mM). For the assay, the substrate was diluted 1◊ reaction buffer to a conce...


US Patent US10414797 (2019)


BindingDB Entry DOI: 10.7270/Q2KS6TWP
More data for this
Ligand-Target Pair
Stromelysin-1


(Homo sapiens (Human))
BDBM413583
PNG
((2S)—N-[(1S)-1-[[(1S)-3-benzamido-1-(hydroxyc...)
Show SMILES CCCCCC(=O)N1CCC[C@H]1C(=O)N(C)[C@@H](C(C)CC)C(=O)N[C@@H](CCNC(=O)c1ccccc1)C(=O)NO
Show InChI InChI=1S/C29H45N5O6/c1-5-7-9-16-24(35)34-19-12-15-23(34)29(39)33(4)25(20(3)6-2)28(38)31-22(27(37)32-40)17-18-30-26(36)21-13-10-8-11-14-21/h8,10-11,13-14,20,22-23,25,40H,5-7,9,12,15-19H2,1-4H3,(H,30,36)(H,31,38)(H,32,37)/t20?,22-,23-,25-/m0/s1
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n/an/a 9.89E+6n/an/an/an/an/an/a



Iproteos S.L

US Patent


Assay Description
MMP-3: Preparation of the MMP-3 for the activity assay: MMP-3 was provided as a stock solution (0.1 mg/mL). The enzyme was diluted in water to a fina...


US Patent US10414797 (2019)


BindingDB Entry DOI: 10.7270/Q2KS6TWP
More data for this
Ligand-Target Pair
Interstitial collagenase


(Homo sapiens (Human))
BDBM413583
PNG
((2S)—N-[(1S)-1-[[(1S)-3-benzamido-1-(hydroxyc...)
Show SMILES CCCCCC(=O)N1CCC[C@H]1C(=O)N(C)[C@@H](C(C)CC)C(=O)N[C@@H](CCNC(=O)c1ccccc1)C(=O)NO
Show InChI InChI=1S/C29H45N5O6/c1-5-7-9-16-24(35)34-19-12-15-23(34)29(39)33(4)25(20(3)6-2)28(38)31-22(27(37)32-40)17-18-30-26(36)21-13-10-8-11-14-21/h8,10-11,13-14,20,22-23,25,40H,5-7,9,12,15-19H2,1-4H3,(H,30,36)(H,31,38)(H,32,37)/t20?,22-,23-,25-/m0/s1
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n/an/a 1.08E+7n/an/an/an/an/an/a



Iproteos S.L

US Patent


Assay Description
MMP-1:MMP-1 peptide substrate was provided as a stock solution in DMSO (6 mM). For the assay, the substrate was diluted 1◊ reaction buffer to a conce...


US Patent US10414797 (2019)


BindingDB Entry DOI: 10.7270/Q2KS6TWP
More data for this
Ligand-Target Pair
Interstitial collagenase


(Homo sapiens (Human))
BDBM413576
PNG
((2S)—N-[(1S)-1-[[(1S)-3-[(3,5-difluorobenzoyl...)
Show SMILES CCC(C)[C@H](N(C)C(=O)[C@@H]1CCCN1C(=O)CCCOc1ccccc1)C(=O)N[C@@H](CCNC(=O)c1cc(F)cc(F)c1)C(=O)NO
Show InChI InChI=1S/C33H43F2N5O7/c1-4-21(2)29(32(44)37-26(31(43)38-46)14-15-36-30(42)22-18-23(34)20-24(35)19-22)39(3)33(45)27-12-8-16-40(27)28(41)13-9-17-47-25-10-6-5-7-11-25/h5-7,10-11,18-21,26-27,29,46H,4,8-9,12-17H2,1-3H3,(H,36,42)(H,37,44)(H,38,43)/t21?,26-,27-,29-/m0/s1
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n/an/a 1.14E+7n/an/an/an/an/an/a



Iproteos S.L

US Patent


Assay Description
MMP-1:MMP-1 peptide substrate was provided as a stock solution in DMSO (6 mM). For the assay, the substrate was diluted 1◊ reaction buffer to a conce...


US Patent US10414797 (2019)


BindingDB Entry DOI: 10.7270/Q2KS6TWP
More data for this
Ligand-Target Pair
Stromelysin-1


(Homo sapiens (Human))
BDBM413571
PNG
((2S)-1-butanoyl-N-[(1S)-1-[[(1S)-3-[(3,5-difluorob...)
Show SMILES CCCC(=O)N1CCC[C@H]1C(=O)N(C)[C@@H](C(C)CC)C(=O)N[C@@H](CCNC(=O)c1cc(F)cc(F)c1)C(=O)NO
Show InChI InChI=1S/C27H39F2N5O6/c1-5-8-22(35)34-12-7-9-21(34)27(39)33(4)23(16(3)6-2)26(38)31-20(25(37)32-40)10-11-30-24(36)17-13-18(28)15-19(29)14-17/h13-16,20-21,23,40H,5-12H2,1-4H3,(H,30,36)(H,31,38)(H,32,37)/t16?,20-,21-,23-/m0/s1
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n/an/a 1.33E+7n/an/an/an/an/an/a



Iproteos S.L

US Patent


Assay Description
MMP-3: Preparation of the MMP-3 for the activity assay: MMP-3 was provided as a stock solution (0.1 mg/mL). The enzyme was diluted in water to a fina...


US Patent US10414797 (2019)


BindingDB Entry DOI: 10.7270/Q2KS6TWP
More data for this
Ligand-Target Pair
Matrix metalloproteinase 7


(Homo sapiens (Human))
BDBM413580
PNG
((2 S)-1-[(2S)-2-[acetyl(methyl)amino]propanoyl]-N-...)
Show SMILES CCC(C)[C@H](N(C)C(=O)[C@@H]1CCCN1C(=O)[C@H](C)N(C)C(C)=O)C(=O)N[C@@H](CCNC(=O)c1cc(F)cc(F)c1)C(=O)NO
Show InChI InChI=1S/C29H42F2N6O7/c1-7-16(2)24(36(6)29(43)23-9-8-12-37(23)28(42)17(3)35(5)18(4)38)27(41)33-22(26(40)34-44)10-11-32-25(39)19-13-20(30)15-21(31)14-19/h13-17,22-24,44H,7-12H2,1-6H3,(H,32,39)(H,33,41)(H,34,40)/t16?,17-,22-,23-,24-/m0/s1
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n/an/a 1.41E+7n/an/an/an/an/an/a



Iproteos S.L

US Patent


Assay Description
MMP-7: Recombinant MMP-7 expressed in E. Coli was obtained from Merck-Millipore (catalog number 44270). Mca-PLGL-Dpa-AR-NH2 (fluorogenic peptide subs...


US Patent US10414797 (2019)


BindingDB Entry DOI: 10.7270/Q2KS6TWP
More data for this
Ligand-Target Pair
Interstitial collagenase


(Homo sapiens (Human))
BDBM413580
PNG
((2 S)-1-[(2S)-2-[acetyl(methyl)amino]propanoyl]-N-...)
Show SMILES CCC(C)[C@H](N(C)C(=O)[C@@H]1CCCN1C(=O)[C@H](C)N(C)C(C)=O)C(=O)N[C@@H](CCNC(=O)c1cc(F)cc(F)c1)C(=O)NO
Show InChI InChI=1S/C29H42F2N6O7/c1-7-16(2)24(36(6)29(43)23-9-8-12-37(23)28(42)17(3)35(5)18(4)38)27(41)33-22(26(40)34-44)10-11-32-25(39)19-13-20(30)15-21(31)14-19/h13-17,22-24,44H,7-12H2,1-6H3,(H,32,39)(H,33,41)(H,34,40)/t16?,17-,22-,23-,24-/m0/s1
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n/an/a 1.49E+7n/an/an/an/an/an/a



Iproteos S.L

US Patent


Assay Description
MMP-1:MMP-1 peptide substrate was provided as a stock solution in DMSO (6 mM). For the assay, the substrate was diluted 1◊ reaction buffer to a conce...


US Patent US10414797 (2019)


BindingDB Entry DOI: 10.7270/Q2KS6TWP
More data for this
Ligand-Target Pair
Stromelysin-1


(Homo sapiens (Human))
BDBM413569
PNG
((2S)-1-acetyl-N-[(1S)-1-[[(1S)-3-[(3,5-difluoroben...)
Show SMILES CCC(C)[C@H](N(C)C(=O)[C@@H]1CCCN1C(C)=O)C(=O)N[C@@H](CCNC(=O)c1cc(F)cc(F)c1)C(=O)NO
Show InChI InChI=1S/C25H35F2N5O6/c1-5-14(2)21(31(4)25(37)20-7-6-10-32(20)15(3)33)24(36)29-19(23(35)30-38)8-9-28-22(34)16-11-17(26)13-18(27)12-16/h11-14,19-21,38H,5-10H2,1-4H3,(H,28,34)(H,29,36)(H,30,35)/t14?,19-,20-,21-/m0/s1
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n/an/a 1.92E+7n/an/an/an/an/an/a



Iproteos S.L

US Patent


Assay Description
MMP-3: Preparation of the MMP-3 for the activity assay: MMP-3 was provided as a stock solution (0.1 mg/mL). The enzyme was diluted in water to a fina...


US Patent US10414797 (2019)


BindingDB Entry DOI: 10.7270/Q2KS6TWP
More data for this
Ligand-Target Pair
Matrix metalloproteinase 7


(Homo sapiens (Human))
BDBM413579
PNG
((2 S)-1-[(2S)-2-[acetyl(methyl)amino]-3-phenyl-pro...)
Show SMILES CCC(C)[C@H](N(C)C(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccccc1)N(C)C(C)=O)C(=O)N[C@@H](CCNC(=O)c1cc(F)cc(F)c1)C(=O)NO
Show InChI InChI=1S/C35H46F2N6O7/c1-6-21(2)30(33(47)39-27(32(46)40-50)14-15-38-31(45)24-18-25(36)20-26(37)19-24)42(5)34(48)28-13-10-16-43(28)35(49)29(41(4)22(3)44)17-23-11-8-7-9-12-23/h7-9,11-12,18-21,27-30,50H,6,10,13-17H2,1-5H3,(H,38,45)(H,39,47)(H,40,46)/t21?,27-,28-,29-,30-/m0/s1
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n/an/a 2.01E+7n/an/an/an/an/an/a



Iproteos S.L

US Patent


Assay Description
MMP-7: Recombinant MMP-7 expressed in E. Coli was obtained from Merck-Millipore (catalog number 44270). Mca-PLGL-Dpa-AR-NH2 (fluorogenic peptide subs...


US Patent US10414797 (2019)


BindingDB Entry DOI: 10.7270/Q2KS6TWP
More data for this
Ligand-Target Pair
Stromelysin-1


(Homo sapiens (Human))
BDBM413574
PNG
((2S)—N-[(1S)-1-[[(1S)-3-[(3,5-difluorobenzoyl...)
Show SMILES CCCCCC(=O)N1CC(F)(F)C[C@H]1C(=O)N(C)[C@@H](C(C)CC)C(=O)N[C@@H](CCNC(=O)c1cc(F)cc(F)c1)C(=O)NO
Show InChI InChI=1S/C29H41F4N5O6/c1-5-7-8-9-23(39)38-16-29(32,33)15-22(38)28(43)37(4)24(17(3)6-2)27(42)35-21(26(41)36-44)10-11-34-25(40)18-12-19(30)14-20(31)13-18/h12-14,17,21-22,24,44H,5-11,15-16H2,1-4H3,(H,34,40)(H,35,42)(H,36,41)/t17?,21-,22-,24-/m0/s1
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n/an/a 2.25E+7n/an/an/an/an/an/a



Iproteos S.L

US Patent


Assay Description
MMP-3: Preparation of the MMP-3 for the activity assay: MMP-3 was provided as a stock solution (0.1 mg/mL). The enzyme was diluted in water to a fina...


US Patent US10414797 (2019)


BindingDB Entry DOI: 10.7270/Q2KS6TWP
More data for this
Ligand-Target Pair
Matrix metalloproteinase 7


(Homo sapiens (Human))
BDBM413568
PNG
((2S)-1-acetyl-N-[(1S)-1-[[(1S)-3-[(4-fluorobenzoyl...)
Show SMILES CCC(C)[C@H](N(C)C(=O)[C@@H]1CCCN1C(C)=O)C(=O)N[C@@H](CCNC(=O)c1ccc(F)cc1)C(=O)NO
Show InChI InChI=1S/C25H36FN5O6/c1-5-15(2)21(30(4)25(36)20-7-6-14-31(20)16(3)32)24(35)28-19(23(34)29-37)12-13-27-22(33)17-8-10-18(26)11-9-17/h8-11,15,19-21,37H,5-7,12-14H2,1-4H3,(H,27,33)(H,28,35)(H,29,34)/t15?,19-,20-,21-/m0/s1
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n/an/a 2.30E+7n/an/an/an/an/an/a



Iproteos S.L

US Patent


Assay Description
MMP-7: Recombinant MMP-7 expressed in E. Coli was obtained from Merck-Millipore (catalog number 44270). Mca-PLGL-Dpa-AR-NH2 (fluorogenic peptide subs...


US Patent US10414797 (2019)


BindingDB Entry DOI: 10.7270/Q2KS6TWP
More data for this
Ligand-Target Pair
Interstitial collagenase


(Homo sapiens (Human))
BDBM413574
PNG
((2S)—N-[(1S)-1-[[(1S)-3-[(3,5-difluorobenzoyl...)
Show SMILES CCCCCC(=O)N1CC(F)(F)C[C@H]1C(=O)N(C)[C@@H](C(C)CC)C(=O)N[C@@H](CCNC(=O)c1cc(F)cc(F)c1)C(=O)NO
Show InChI InChI=1S/C29H41F4N5O6/c1-5-7-8-9-23(39)38-16-29(32,33)15-22(38)28(43)37(4)24(17(3)6-2)27(42)35-21(26(41)36-44)10-11-34-25(40)18-12-19(30)14-20(31)13-18/h12-14,17,21-22,24,44H,5-11,15-16H2,1-4H3,(H,34,40)(H,35,42)(H,36,41)/t17?,21-,22-,24-/m0/s1
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n/an/a 2.47E+7n/an/an/an/an/an/a



Iproteos S.L

US Patent


Assay Description
MMP-1:MMP-1 peptide substrate was provided as a stock solution in DMSO (6 mM). For the assay, the substrate was diluted 1◊ reaction buffer to a conce...


US Patent US10414797 (2019)


BindingDB Entry DOI: 10.7270/Q2KS6TWP
More data for this
Ligand-Target Pair
Stromelysin-1


(Homo sapiens (Human))
BDBM413570
PNG
((2S)—N-[(1S)-1-[[(1S)-3-[(3,5-difluorobenzoyl...)
Show SMILES CCCCCC(=O)N1CCC[C@H]1C(=O)N(C)[C@@H](C(C)CC)C(=O)N[C@@H](CCNC(=O)c1cc(F)cc(F)c1)C(=O)NO
Show InChI InChI=1S/C29H43F2N5O6/c1-5-7-8-11-24(37)36-14-9-10-23(36)29(41)35(4)25(18(3)6-2)28(40)33-22(27(39)34-42)12-13-32-26(38)19-15-20(30)17-21(31)16-19/h15-18,22-23,25,42H,5-14H2,1-4H3,(H,32,38)(H,33,40)(H,34,39)/t18?,22-,23-,25-/m0/s1
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n/an/a 2.54E+7n/an/an/an/an/an/a



Iproteos S.L

US Patent


Assay Description
MMP-3: Preparation of the MMP-3 for the activity assay: MMP-3 was provided as a stock solution (0.1 mg/mL). The enzyme was diluted in water to a fina...


US Patent US10414797 (2019)


BindingDB Entry DOI: 10.7270/Q2KS6TWP
More data for this
Ligand-Target Pair
Interstitial collagenase


(Homo sapiens (Human))
BDBM413573
PNG
((2S)—N-[(1S)-1-[[(1S)-3-[(3,5-difluorobenzoyl...)
Show SMILES CCCCCCCC(=O)N1CCC[C@H]1C(=O)N(C)[C@@H](C(C)CC)C(=O)N[C@@H](CCNC(=O)c1cc(F)cc(F)c1)C(=O)NO
Show InChI InChI=1S/C31H47F2N5O6/c1-5-7-8-9-10-13-26(39)38-16-11-12-25(38)31(43)37(4)27(20(3)6-2)30(42)35-24(29(41)36-44)14-15-34-28(40)21-17-22(32)19-23(33)18-21/h17-20,24-25,27,44H,5-16H2,1-4H3,(H,34,40)(H,35,42)(H,36,41)/t20?,24-,25-,27-/m0/s1
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n/an/a 2.56E+7n/an/an/an/an/an/a



Iproteos S.L

US Patent


Assay Description
MMP-1:MMP-1 peptide substrate was provided as a stock solution in DMSO (6 mM). For the assay, the substrate was diluted 1◊ reaction buffer to a conce...


US Patent US10414797 (2019)


BindingDB Entry DOI: 10.7270/Q2KS6TWP
More data for this
Ligand-Target Pair
Stromelysin-1


(Homo sapiens (Human))
BDBM413572
PNG
((2S)—N-[(1S)-1-[[(1S)-3-[(3,5-difluorobenzoyl...)
Show SMILES CCC(C)[C@H](N(C)C(=O)[C@@H]1CCCN1C(=O)CC(C)C)C(=O)N[C@@H](CCNC(=O)c1cc(F)cc(F)c1)C(=O)NO
Show InChI InChI=1S/C28H41F2N5O6/c1-6-17(4)24(34(5)28(40)22-8-7-11-35(22)23(36)12-16(2)3)27(39)32-21(26(38)33-41)9-10-31-25(37)18-13-19(29)15-20(30)14-18/h13-17,21-22,24,41H,6-12H2,1-5H3,(H,31,37)(H,32,39)(H,33,38)/t17?,21-,22-,24-/m0/s1
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n/an/a 2.57E+7n/an/an/an/an/an/a



Iproteos S.L

US Patent


Assay Description
MMP-3: Preparation of the MMP-3 for the activity assay: MMP-3 was provided as a stock solution (0.1 mg/mL). The enzyme was diluted in water to a fina...


US Patent US10414797 (2019)


BindingDB Entry DOI: 10.7270/Q2KS6TWP
More data for this
Ligand-Target Pair
Stromelysin-1


(Homo sapiens (Human))
BDBM413568
PNG
((2S)-1-acetyl-N-[(1S)-1-[[(1S)-3-[(4-fluorobenzoyl...)
Show SMILES CCC(C)[C@H](N(C)C(=O)[C@@H]1CCCN1C(C)=O)C(=O)N[C@@H](CCNC(=O)c1ccc(F)cc1)C(=O)NO
Show InChI InChI=1S/C25H36FN5O6/c1-5-15(2)21(30(4)25(36)20-7-6-14-31(20)16(3)32)24(35)28-19(23(34)29-37)12-13-27-22(33)17-8-10-18(26)11-9-17/h8-11,15,19-21,37H,5-7,12-14H2,1-4H3,(H,27,33)(H,28,35)(H,29,34)/t15?,19-,20-,21-/m0/s1
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n/an/a 3.01E+7n/an/an/an/an/an/a



Iproteos S.L

US Patent


Assay Description
MMP-3: Preparation of the MMP-3 for the activity assay: MMP-3 was provided as a stock solution (0.1 mg/mL). The enzyme was diluted in water to a fina...


US Patent US10414797 (2019)


BindingDB Entry DOI: 10.7270/Q2KS6TWP
More data for this
Ligand-Target Pair
Matrix metalloproteinase 7


(Homo sapiens (Human))
BDBM413569
PNG
((2S)-1-acetyl-N-[(1S)-1-[[(1S)-3-[(3,5-difluoroben...)
Show SMILES CCC(C)[C@H](N(C)C(=O)[C@@H]1CCCN1C(C)=O)C(=O)N[C@@H](CCNC(=O)c1cc(F)cc(F)c1)C(=O)NO
Show InChI InChI=1S/C25H35F2N5O6/c1-5-14(2)21(31(4)25(37)20-7-6-10-32(20)15(3)33)24(36)29-19(23(35)30-38)8-9-28-22(34)16-11-17(26)13-18(27)12-16/h11-14,19-21,38H,5-10H2,1-4H3,(H,28,34)(H,29,36)(H,30,35)/t14?,19-,20-,21-/m0/s1
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n/an/a 3.14E+7n/an/an/an/an/an/a



Iproteos S.L

US Patent


Assay Description
MMP-7: Recombinant MMP-7 expressed in E. Coli was obtained from Merck-Millipore (catalog number 44270). Mca-PLGL-Dpa-AR-NH2 (fluorogenic peptide subs...


US Patent US10414797 (2019)


BindingDB Entry DOI: 10.7270/Q2KS6TWP
More data for this
Ligand-Target Pair
Matrix metalloproteinase 7


(Homo sapiens (Human))
BDBM413576
PNG
((2S)—N-[(1S)-1-[[(1S)-3-[(3,5-difluorobenzoyl...)
Show SMILES CCC(C)[C@H](N(C)C(=O)[C@@H]1CCCN1C(=O)CCCOc1ccccc1)C(=O)N[C@@H](CCNC(=O)c1cc(F)cc(F)c1)C(=O)NO
Show InChI InChI=1S/C33H43F2N5O7/c1-4-21(2)29(32(44)37-26(31(43)38-46)14-15-36-30(42)22-18-23(34)20-24(35)19-22)39(3)33(45)27-12-8-16-40(27)28(41)13-9-17-47-25-10-6-5-7-11-25/h5-7,10-11,18-21,26-27,29,46H,4,8-9,12-17H2,1-3H3,(H,36,42)(H,37,44)(H,38,43)/t21?,26-,27-,29-/m0/s1
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n/an/a 4.03E+7n/an/an/an/an/an/a



Iproteos S.L

US Patent


Assay Description
MMP-7: Recombinant MMP-7 expressed in E. Coli was obtained from Merck-Millipore (catalog number 44270). Mca-PLGL-Dpa-AR-NH2 (fluorogenic peptide subs...


US Patent US10414797 (2019)


BindingDB Entry DOI: 10.7270/Q2KS6TWP
More data for this
Ligand-Target Pair
Matrix metalloproteinase 7


(Homo sapiens (Human))
BDBM413583
PNG
((2S)—N-[(1S)-1-[[(1S)-3-benzamido-1-(hydroxyc...)
Show SMILES CCCCCC(=O)N1CCC[C@H]1C(=O)N(C)[C@@H](C(C)CC)C(=O)N[C@@H](CCNC(=O)c1ccccc1)C(=O)NO
Show InChI InChI=1S/C29H45N5O6/c1-5-7-9-16-24(35)34-19-12-15-23(34)29(39)33(4)25(20(3)6-2)28(38)31-22(27(37)32-40)17-18-30-26(36)21-13-10-8-11-14-21/h8,10-11,13-14,20,22-23,25,40H,5-7,9,12,15-19H2,1-4H3,(H,30,36)(H,31,38)(H,32,37)/t20?,22-,23-,25-/m0/s1
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n/an/a 4.12E+7n/an/an/an/an/an/a



Iproteos S.L

US Patent


Assay Description
MMP-7: Recombinant MMP-7 expressed in E. Coli was obtained from Merck-Millipore (catalog number 44270). Mca-PLGL-Dpa-AR-NH2 (fluorogenic peptide subs...


US Patent US10414797 (2019)


BindingDB Entry DOI: 10.7270/Q2KS6TWP
More data for this
Ligand-Target Pair
Matrix metalloproteinase 7


(Homo sapiens (Human))
BDBM413581
PNG
((2S)-1-[3-[acetyl(methyl)amino]propanoyl]-N-[(1S)-...)
Show SMILES CCC(C)[C@H](N(C)C(=O)[C@@H]1CCCN1C(=O)CCN(C)C(C)=O)C(=O)N[C@@H](CCNC(=O)c1cc(F)cc(F)c1)C(=O)NO
Show InChI InChI=1S/C29H42F2N6O7/c1-6-17(2)25(36(5)29(43)23-8-7-12-37(23)24(39)10-13-35(4)18(3)38)28(42)33-22(27(41)34-44)9-11-32-26(40)19-14-20(30)16-21(31)15-19/h14-17,22-23,25,44H,6-13H2,1-5H3,(H,32,40)(H,33,42)(H,34,41)/t17?,22-,23-,25-/m0/s1
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n/an/a 5.04E+7n/an/an/an/an/an/a



Iproteos S.L

US Patent


Assay Description
MMP-7: Recombinant MMP-7 expressed in E. Coli was obtained from Merck-Millipore (catalog number 44270). Mca-PLGL-Dpa-AR-NH2 (fluorogenic peptide subs...


US Patent US10414797 (2019)


BindingDB Entry DOI: 10.7270/Q2KS6TWP
More data for this
Ligand-Target Pair
Matrix metalloproteinase 7


(Homo sapiens (Human))
BDBM413573
PNG
((2S)—N-[(1S)-1-[[(1S)-3-[(3,5-difluorobenzoyl...)
Show SMILES CCCCCCCC(=O)N1CCC[C@H]1C(=O)N(C)[C@@H](C(C)CC)C(=O)N[C@@H](CCNC(=O)c1cc(F)cc(F)c1)C(=O)NO
Show InChI InChI=1S/C31H47F2N5O6/c1-5-7-8-9-10-13-26(39)38-16-11-12-25(38)31(43)37(4)27(20(3)6-2)30(42)35-24(29(41)36-44)14-15-34-28(40)21-17-22(32)19-23(33)18-21/h17-20,24-25,27,44H,5-16H2,1-4H3,(H,34,40)(H,35,42)(H,36,41)/t20?,24-,25-,27-/m0/s1
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n/an/a 5.26E+7n/an/an/an/an/an/a



Iproteos S.L

US Patent


Assay Description
MMP-7: Recombinant MMP-7 expressed in E. Coli was obtained from Merck-Millipore (catalog number 44270). Mca-PLGL-Dpa-AR-NH2 (fluorogenic peptide subs...


US Patent US10414797 (2019)


BindingDB Entry DOI: 10.7270/Q2KS6TWP
More data for this
Ligand-Target Pair
Stromelysin-1


(Homo sapiens (Human))
BDBM413573
PNG
((2S)—N-[(1S)-1-[[(1S)-3-[(3,5-difluorobenzoyl...)
Show SMILES CCCCCCCC(=O)N1CCC[C@H]1C(=O)N(C)[C@@H](C(C)CC)C(=O)N[C@@H](CCNC(=O)c1cc(F)cc(F)c1)C(=O)NO
Show InChI InChI=1S/C31H47F2N5O6/c1-5-7-8-9-10-13-26(39)38-16-11-12-25(38)31(43)37(4)27(20(3)6-2)30(42)35-24(29(41)36-44)14-15-34-28(40)21-17-22(32)19-23(33)18-21/h17-20,24-25,27,44H,5-16H2,1-4H3,(H,34,40)(H,35,42)(H,36,41)/t20?,24-,25-,27-/m0/s1
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n/an/a 5.34E+7n/an/an/an/an/an/a



Iproteos S.L

US Patent


Assay Description
MMP-3: Preparation of the MMP-3 for the activity assay: MMP-3 was provided as a stock solution (0.1 mg/mL). The enzyme was diluted in water to a fina...


US Patent US10414797 (2019)


BindingDB Entry DOI: 10.7270/Q2KS6TWP
More data for this
Ligand-Target Pair
Matrix metalloproteinase 7


(Homo sapiens (Human))
BDBM413582
PNG
((2S)-1-[(2S)-2-[[(2S)-2-[butanoyl(methyl)amino]-3-...)
Show SMILES CCCC(=O)N(C)[C@@H](Cc1c[nH]c2ccccc12)C(=O)N(C)[C@@H](CC(C)C)C(=O)N1CCC[C@H]1C(=O)N(C)[C@@H](C(C)CC)C(=O)N[C@@H](CCNC(=O)c1cc(F)cc(F)c1)C(=O)NO
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n/an/a 6.10E+7n/an/an/an/an/an/a



Iproteos S.L

US Patent


Assay Description
MMP-7: Recombinant MMP-7 expressed in E. Coli was obtained from Merck-Millipore (catalog number 44270). Mca-PLGL-Dpa-AR-NH2 (fluorogenic peptide subs...


US Patent US10414797 (2019)


BindingDB Entry DOI: 10.7270/Q2KS6TWP
More data for this
Ligand-Target Pair
Stromelysin-1


(Homo sapiens (Human))
BDBM413580
PNG
((2 S)-1-[(2S)-2-[acetyl(methyl)amino]propanoyl]-N-...)
Show SMILES CCC(C)[C@H](N(C)C(=O)[C@@H]1CCCN1C(=O)[C@H](C)N(C)C(C)=O)C(=O)N[C@@H](CCNC(=O)c1cc(F)cc(F)c1)C(=O)NO
Show InChI InChI=1S/C29H42F2N6O7/c1-7-16(2)24(36(6)29(43)23-9-8-12-37(23)28(42)17(3)35(5)18(4)38)27(41)33-22(26(40)34-44)10-11-32-25(39)19-13-20(30)15-21(31)14-19/h13-17,22-24,44H,7-12H2,1-6H3,(H,32,39)(H,33,41)(H,34,40)/t16?,17-,22-,23-,24-/m0/s1
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n/an/a 1.57E+8n/an/an/an/an/an/a



Iproteos S.L

US Patent


Assay Description
MMP-3: Preparation of the MMP-3 for the activity assay: MMP-3 was provided as a stock solution (0.1 mg/mL). The enzyme was diluted in water to a fina...


US Patent US10414797 (2019)


BindingDB Entry DOI: 10.7270/Q2KS6TWP
More data for this
Ligand-Target Pair
Stromelysin-1


(Homo sapiens (Human))
BDBM413577
PNG
((2S)—N-[(1S)-1-[[(1S)-3-[(3,5-difluorobenzoyl...)
Show SMILES CCC(C)[C@H](N(C)C(=O)[C@@H]1CC(F)(F)CN1C(=O)CCCOc1ccccc1)C(=O)N[C@@H](CCNC(=O)c1cc(F)cc(F)c1)C(=O)NO
Show InChI InChI=1S/C33H41F4N5O7/c1-4-20(2)28(31(46)39-25(30(45)40-48)12-13-38-29(44)21-15-22(34)17-23(35)16-21)41(3)32(47)26-18-33(36,37)19-42(26)27(43)11-8-14-49-24-9-6-5-7-10-24/h5-7,9-10,15-17,20,25-26,28,48H,4,8,11-14,18-19H2,1-3H3,(H,38,44)(H,39,46)(H,40,45)/t20?,25-,26-,28-/m0/s1
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n/an/a 1.60E+8n/an/an/an/an/an/a



Iproteos S.L

US Patent


Assay Description
MMP-3: Preparation of the MMP-3 for the activity assay: MMP-3 was provided as a stock solution (0.1 mg/mL). The enzyme was diluted in water to a fina...


US Patent US10414797 (2019)


BindingDB Entry DOI: 10.7270/Q2KS6TWP
More data for this
Ligand-Target Pair
Stromelysin-1


(Homo sapiens (Human))
BDBM413579
PNG
((2 S)-1-[(2S)-2-[acetyl(methyl)amino]-3-phenyl-pro...)
Show SMILES CCC(C)[C@H](N(C)C(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccccc1)N(C)C(C)=O)C(=O)N[C@@H](CCNC(=O)c1cc(F)cc(F)c1)C(=O)NO
Show InChI InChI=1S/C35H46F2N6O7/c1-6-21(2)30(33(47)39-27(32(46)40-50)14-15-38-31(45)24-18-25(36)20-26(37)19-24)42(5)34(48)28-13-10-16-43(28)35(49)29(41(4)22(3)44)17-23-11-8-7-9-12-23/h7-9,11-12,18-21,27-30,50H,6,10,13-17H2,1-5H3,(H,38,45)(H,39,47)(H,40,46)/t21?,27-,28-,29-,30-/m0/s1
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n/an/a 2.00E+8n/an/an/an/an/an/a



Iproteos S.L

US Patent


Assay Description
MMP-3: Preparation of the MMP-3 for the activity assay: MMP-3 was provided as a stock solution (0.1 mg/mL). The enzyme was diluted in water to a fina...


US Patent US10414797 (2019)


BindingDB Entry DOI: 10.7270/Q2KS6TWP
More data for this
Ligand-Target Pair
Interstitial collagenase


(Homo sapiens (Human))
BDBM413581
PNG
((2S)-1-[3-[acetyl(methyl)amino]propanoyl]-N-[(1S)-...)
Show SMILES CCC(C)[C@H](N(C)C(=O)[C@@H]1CCCN1C(=O)CCN(C)C(C)=O)C(=O)N[C@@H](CCNC(=O)c1cc(F)cc(F)c1)C(=O)NO
Show InChI InChI=1S/C29H42F2N6O7/c1-6-17(2)25(36(5)29(43)23-8-7-12-37(23)24(39)10-13-35(4)18(3)38)28(42)33-22(27(41)34-44)9-11-32-26(40)19-14-20(30)16-21(31)15-19/h14-17,22-23,25,44H,6-13H2,1-5H3,(H,32,40)(H,33,42)(H,34,41)/t17?,22-,23-,25-/m0/s1
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n/an/a 2.00E+8n/an/an/an/an/an/a



Iproteos S.L

US Patent


Assay Description
MMP-1:MMP-1 peptide substrate was provided as a stock solution in DMSO (6 mM). For the assay, the substrate was diluted 1◊ reaction buffer to a conce...


US Patent US10414797 (2019)


BindingDB Entry DOI: 10.7270/Q2KS6TWP
More data for this
Ligand-Target Pair
Stromelysin-1


(Homo sapiens (Human))
BDBM413581
PNG
((2S)-1-[3-[acetyl(methyl)amino]propanoyl]-N-[(1S)-...)
Show SMILES CCC(C)[C@H](N(C)C(=O)[C@@H]1CCCN1C(=O)CCN(C)C(C)=O)C(=O)N[C@@H](CCNC(=O)c1cc(F)cc(F)c1)C(=O)NO
Show InChI InChI=1S/C29H42F2N6O7/c1-6-17(2)25(36(5)29(43)23-8-7-12-37(23)24(39)10-13-35(4)18(3)38)28(42)33-22(27(41)34-44)9-11-32-26(40)19-14-20(30)16-21(31)15-19/h14-17,22-23,25,44H,6-13H2,1-5H3,(H,32,40)(H,33,42)(H,34,41)/t17?,22-,23-,25-/m0/s1
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n/an/a 2.00E+8n/an/an/an/an/an/a



Iproteos S.L

US Patent


Assay Description
MMP-3: Preparation of the MMP-3 for the activity assay: MMP-3 was provided as a stock solution (0.1 mg/mL). The enzyme was diluted in water to a fina...


US Patent US10414797 (2019)


BindingDB Entry DOI: 10.7270/Q2KS6TWP
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%