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Patent code US10421756

Compile Data Set for Download or QSAR
Found 152 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Histone deacetylase 2


(Homo sapiens (Human))
BDBM413916
PNG
(US10421756, Compound 100)
Show SMILES Nc1ccc(cc1NC(=O)N1Cc2cncnc2C1)-c1ccncc1
Show InChI InChI=1S/C18H16N6O/c19-15-2-1-13(12-3-5-20-6-4-12)7-16(15)23-18(25)24-9-14-8-21-11-22-17(14)10-24/h1-8,11H,9-10,19H2,(H,23,25)
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n/an/an/a 0n/an/an/an/an/a



Rodin Therapeutics, Inc.

US Patent


Assay Description
HDAC2 containing a C-terminal HIS-Tag (Proteros) and fluorescently-labeled anti-HIS-antibody are diluted in one vial in assay buffer 50 mM Tris, pH 8...


US Patent US10421756 (2019)


BindingDB Entry DOI: 10.7270/Q2PK0JGK
More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))
BDBM413918
PNG
(US10421756, Compound 102)
Show SMILES Nc1ccc(cc1NC(=O)N1Cc2ccncc2C1)-c1ccncc1
Show InChI InChI=1S/C19H17N5O/c20-17-2-1-14(13-3-6-21-7-4-13)9-18(17)23-19(25)24-11-15-5-8-22-10-16(15)12-24/h1-10H,11-12,20H2,(H,23,25)
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n/an/an/a<100n/an/an/an/an/a



Rodin Therapeutics, Inc.

US Patent


Assay Description
HDAC2 containing a C-terminal HIS-Tag (Proteros) and fluorescently-labeled anti-HIS-antibody are diluted in one vial in assay buffer 50 mM Tris, pH 8...


US Patent US10421756 (2019)


BindingDB Entry DOI: 10.7270/Q2PK0JGK
More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))
BDBM413919
PNG
(US10421756, Compound 103)
Show SMILES Nc1ccc(cc1NC(=O)N1Cc2ccncc2C1)-c1ccncn1
Show InChI InChI=1S/C18H16N6O/c19-15-2-1-12(16-4-6-21-11-22-16)7-17(15)23-18(25)24-9-13-3-5-20-8-14(13)10-24/h1-8,11H,9-10,19H2,(H,23,25)
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n/an/an/a 2.75E+3n/an/an/an/an/a



Rodin Therapeutics, Inc.

US Patent


Assay Description
HDAC2 containing a C-terminal HIS-Tag (Proteros) and fluorescently-labeled anti-HIS-antibody are diluted in one vial in assay buffer 50 mM Tris, pH 8...


US Patent US10421756 (2019)


BindingDB Entry DOI: 10.7270/Q2PK0JGK
More data for this
Ligand-Target Pair
Histone deacetylase 2


(Homo sapiens (Human))
BDBM413920
PNG
(US10421756, Compound 104)
Show SMILES CC(C)(C)OC(=O)N1CC2CC1CN2C(=O)Nc1cc(ccc1N)-c1ccncc1
Show InChI InChI=1S/C22H27N5O3/c1-22(2,3)30-21(29)27-13-16-11-17(27)12-26(16)20(28)25-19-10-15(4-5-18(19)23)14-6-8-24-9-7-14/h4-10,16-17H,11-13,23H2,1-3H3,(H,25,28)
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Rodin Therapeutics, Inc.

US Patent


Assay Description
HDAC2 containing a C-terminal HIS-Tag (Proteros) and fluorescently-labeled anti-HIS-antibody are diluted in one vial in assay buffer 50 mM Tris, pH 8...


US Patent US10421756 (2019)


BindingDB Entry DOI: 10.7270/Q2PK0JGK
More data for this
Ligand-Target Pair
Histone deacetylase 2


(Homo sapiens (Human))
BDBM413924
PNG
(US10421756, Compound 108)
Show SMILES CC(=O)N1CC2CC1CN2C(=O)Nc1cc(ccc1N)-c1ccncc1
Show InChI InChI=1S/C19H21N5O2/c1-12(25)23-10-16-9-15(23)11-24(16)19(26)22-18-8-14(2-3-17(18)20)13-4-6-21-7-5-13/h2-8,15-16H,9-11,20H2,1H3,(H,22,26)
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Rodin Therapeutics, Inc.

US Patent


Assay Description
HDAC2 containing a C-terminal HIS-Tag (Proteros) and fluorescently-labeled anti-HIS-antibody are diluted in one vial in assay buffer 50 mM Tris, pH 8...


US Patent US10421756 (2019)


BindingDB Entry DOI: 10.7270/Q2PK0JGK
More data for this
Ligand-Target Pair
Histone deacetylase 2


(Homo sapiens (Human))
BDBM413922
PNG
(US10421756, Compound 106 | US10421756, Compound 11...)
Show SMILES CC(C)(C)OC(=O)N1C2CCC1CN(C2)C(=O)Nc1cc(ccc1N)-c1ccncc1
Show InChI InChI=1S/C23H29N5O3/c1-23(2,3)31-22(30)28-17-5-6-18(28)14-27(13-17)21(29)26-20-12-16(4-7-19(20)24)15-8-10-25-11-9-15/h4,7-12,17-18H,5-6,13-14,24H2,1-3H3,(H,26,29)
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Rodin Therapeutics, Inc.

US Patent


Assay Description
HDAC2 containing a C-terminal HIS-Tag (Proteros) and fluorescently-labeled anti-HIS-antibody are diluted in one vial in assay buffer 50 mM Tris, pH 8...


US Patent US10421756 (2019)


BindingDB Entry DOI: 10.7270/Q2PK0JGK
More data for this
Ligand-Target Pair
Histone deacetylase 2


(Homo sapiens (Human))
BDBM413933
PNG
(US10421756, Compound 117)
Show SMILES Nc1ccc(cc1NC(=O)N1CC2CCC(C1)N2C=O)-c1ccc(F)cc1
Show InChI InChI=1S/C20H21FN4O2/c21-15-4-1-13(2-5-15)14-3-8-18(22)19(9-14)23-20(27)24-10-16-6-7-17(11-24)25(16)12-26/h1-5,8-9,12,16-17H,6-7,10-11,22H2,(H,23,27)
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n/an/an/a 2.75E+3n/an/an/an/an/a



Rodin Therapeutics, Inc.

US Patent


Assay Description
HDAC2 containing a C-terminal HIS-Tag (Proteros) and fluorescently-labeled anti-HIS-antibody are diluted in one vial in assay buffer 50 mM Tris, pH 8...


US Patent US10421756 (2019)


BindingDB Entry DOI: 10.7270/Q2PK0JGK
More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))
BDBM413934
PNG
(US10421756, Compound 118)
Show SMILES Nc1ccc(cc1NC(=O)N1CCC2(CCNC2)CC1)-c1ccc(F)cc1
Show InChI InChI=1S/C21H25FN4O/c22-17-4-1-15(2-5-17)16-3-6-18(23)19(13-16)25-20(27)26-11-8-21(9-12-26)7-10-24-14-21/h1-6,13,24H,7-12,14,23H2,(H,25,27)
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n/an/an/a<100n/an/an/an/an/a



Rodin Therapeutics, Inc.

US Patent


Assay Description
HDAC2 containing a C-terminal HIS-Tag (Proteros) and fluorescently-labeled anti-HIS-antibody are diluted in one vial in assay buffer 50 mM Tris, pH 8...


US Patent US10421756 (2019)


BindingDB Entry DOI: 10.7270/Q2PK0JGK
More data for this
Ligand-Target Pair
Histone deacetylase 2


(Homo sapiens (Human))
BDBM413946
PNG
(US10421756, Compound 130)
Show SMILES Nc1ccc(cc1NC(=O)N1Cc2ccncc2C1)-c1ccc(Cl)cc1
Show InChI InChI=1S/C20H17ClN4O/c21-17-4-1-13(2-5-17)14-3-6-18(22)19(9-14)24-20(26)25-11-15-7-8-23-10-16(15)12-25/h1-10H,11-12,22H2,(H,24,26)
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Rodin Therapeutics, Inc.

US Patent


Assay Description
HDAC2 containing a C-terminal HIS-Tag (Proteros) and fluorescently-labeled anti-HIS-antibody are diluted in one vial in assay buffer 50 mM Tris, pH 8...


US Patent US10421756 (2019)


BindingDB Entry DOI: 10.7270/Q2PK0JGK
More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))
BDBM413958
PNG
(US10421756, Compound 142)
Show SMILES Nc1ccc(cc1NC(=O)N1Cc2ccncc2C1)-c1cc(F)c(F)c(F)c1
Show InChI InChI=1S/C20H15F3N4O/c21-15-5-13(6-16(22)19(15)23)11-1-2-17(24)18(7-11)26-20(28)27-9-12-3-4-25-8-14(12)10-27/h1-8H,9-10,24H2,(H,26,28)
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n/an/an/a 2.75E+3n/an/an/an/an/a



Rodin Therapeutics, Inc.

US Patent


Assay Description
HDAC2 containing a C-terminal HIS-Tag (Proteros) and fluorescently-labeled anti-HIS-antibody are diluted in one vial in assay buffer 50 mM Tris, pH 8...


US Patent US10421756 (2019)


BindingDB Entry DOI: 10.7270/Q2PK0JGK
More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))
BDBM413967
PNG
(US10421756, Compound 151)
Show SMILES Nc1ccc(cc1NC(=O)N1Cc2ccncc2C1)-c1ccoc1
Show InChI InChI=1S/C18H16N4O2/c19-16-2-1-12(14-4-6-24-11-14)7-17(16)21-18(23)22-9-13-3-5-20-8-15(13)10-22/h1-8,11H,9-10,19H2,(H,21,23)
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Rodin Therapeutics, Inc.

US Patent


Assay Description
HDAC2 containing a C-terminal HIS-Tag (Proteros) and fluorescently-labeled anti-HIS-antibody are diluted in one vial in assay buffer 50 mM Tris, pH 8...


US Patent US10421756 (2019)


BindingDB Entry DOI: 10.7270/Q2PK0JGK
More data for this
Ligand-Target Pair
Histone deacetylase 2


(Homo sapiens (Human))
BDBM413968
PNG
(US10421756, Compound 152)
Show SMILES CNC(=O)N1CCc2nc(sc2C1)C(=O)Nc1cc(ccc1N)-c1ccc(F)cc1
Show InChI InChI=1S/C21H20FN5O2S/c1-24-21(29)27-9-8-16-18(11-27)30-20(26-16)19(28)25-17-10-13(4-7-15(17)23)12-2-5-14(22)6-3-12/h2-7,10H,8-9,11,23H2,1H3,(H,24,29)(H,25,28)
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Rodin Therapeutics, Inc.

US Patent


Assay Description
HDAC2 containing a C-terminal HIS-Tag (Proteros) and fluorescently-labeled anti-HIS-antibody are diluted in one vial in assay buffer 50 mM Tris, pH 8...


US Patent US10421756 (2019)


BindingDB Entry DOI: 10.7270/Q2PK0JGK
More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))
BDBM413969
PNG
(US10421756, Compound 153)
Show SMILES Nc1ccc(cc1NC(=O)N1CC2(C1)CCCCO2)-c1ccc(F)cc1
Show InChI InChI=1S/C20H22FN3O2/c21-16-6-3-14(4-7-16)15-5-8-17(22)18(11-15)23-19(25)24-12-20(13-24)9-1-2-10-26-20/h3-8,11H,1-2,9-10,12-13,22H2,(H,23,25)
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n/an/an/a 300n/an/an/an/an/a



Rodin Therapeutics, Inc.

US Patent


Assay Description
HDAC2 containing a C-terminal HIS-Tag (Proteros) and fluorescently-labeled anti-HIS-antibody are diluted in one vial in assay buffer 50 mM Tris, pH 8...


US Patent US10421756 (2019)


BindingDB Entry DOI: 10.7270/Q2PK0JGK
More data for this
Ligand-Target Pair
Histone deacetylase 2


(Homo sapiens (Human))
BDBM413971
PNG
(US10421756, Compound 155)
Show SMILES CCOC(=O)N1CC2CN(CC2C1)C(=O)Nc1cc(ccc1N)-c1ccc(F)cc1
Show InChI InChI=1S/C22H25FN4O3/c1-2-30-22(29)27-12-16-10-26(11-17(16)13-27)21(28)25-20-9-15(5-8-19(20)24)14-3-6-18(23)7-4-14/h3-9,16-17H,2,10-13,24H2,1H3,(H,25,28)
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n/an/an/a 2.75E+3n/an/an/an/an/a



Rodin Therapeutics, Inc.

US Patent


Assay Description
HDAC2 containing a C-terminal HIS-Tag (Proteros) and fluorescently-labeled anti-HIS-antibody are diluted in one vial in assay buffer 50 mM Tris, pH 8...


US Patent US10421756 (2019)


BindingDB Entry DOI: 10.7270/Q2PK0JGK
More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))
BDBM413971
PNG
(US10421756, Compound 155)
Show SMILES CCOC(=O)N1CC2CN(CC2C1)C(=O)Nc1cc(ccc1N)-c1ccc(F)cc1
Show InChI InChI=1S/C22H25FN4O3/c1-2-30-22(29)27-12-16-10-26(11-17(16)13-27)21(28)25-20-9-15(5-8-19(20)24)14-3-6-18(23)7-4-14/h3-9,16-17H,2,10-13,24H2,1H3,(H,25,28)
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Rodin Therapeutics, Inc.

US Patent


Assay Description
HDAC2 containing a C-terminal HIS-Tag (Proteros) and fluorescently-labeled anti-HIS-antibody are diluted in one vial in assay buffer 50 mM Tris, pH 8...


US Patent US10421756 (2019)


BindingDB Entry DOI: 10.7270/Q2PK0JGK
More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))
BDBM413982
PNG
(US10421756, Compound 166)
Show SMILES CC(C)(C)OC(=O)N1CCC2(CN(C2)C(=O)Nc2cc(ccc2N)-c2ccc(F)cc2)CC1
Show InChI InChI=1S/C25H31FN4O3/c1-24(2,3)33-23(32)29-12-10-25(11-13-29)15-30(16-25)22(31)28-21-14-18(6-9-20(21)27)17-4-7-19(26)8-5-17/h4-9,14H,10-13,15-16,27H2,1-3H3,(H,28,31)
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Rodin Therapeutics, Inc.

US Patent


Assay Description
HDAC2 containing a C-terminal HIS-Tag (Proteros) and fluorescently-labeled anti-HIS-antibody are diluted in one vial in assay buffer 50 mM Tris, pH 8...


US Patent US10421756 (2019)


BindingDB Entry DOI: 10.7270/Q2PK0JGK
More data for this
Ligand-Target Pair
Histone deacetylase 2


(Homo sapiens (Human))
BDBM413989
PNG
(US10421756, Compound 173)
Show SMILES Nc1ccc(cc1NC(=O)N1CCC2(CCOC2)CC1)-c1ccc(F)cc1
Show InChI InChI=1S/C21H24FN3O2/c22-17-4-1-15(2-5-17)16-3-6-18(23)19(13-16)24-20(26)25-10-7-21(8-11-25)9-12-27-14-21/h1-6,13H,7-12,14,23H2,(H,24,26)
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Rodin Therapeutics, Inc.

US Patent


Assay Description
HDAC2 containing a C-terminal HIS-Tag (Proteros) and fluorescently-labeled anti-HIS-antibody are diluted in one vial in assay buffer 50 mM Tris, pH 8...


US Patent US10421756 (2019)


BindingDB Entry DOI: 10.7270/Q2PK0JGK
More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))
BDBM413991
PNG
(US10421756, Compound 175)
Show SMILES Nc1ccc(cc1NC(=O)c1nc2CNCCc2s1)-c1ccc(F)cc1
Show InChI InChI=1S/C19H17FN4OS/c20-13-4-1-11(2-5-13)12-3-6-14(21)15(9-12)23-18(25)19-24-16-10-22-8-7-17(16)26-19/h1-6,9,22H,7-8,10,21H2,(H,23,25)
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n/an/an/a<100n/an/an/an/an/a



Rodin Therapeutics, Inc.

US Patent


Assay Description
HDAC2 containing a C-terminal HIS-Tag (Proteros) and fluorescently-labeled anti-HIS-antibody are diluted in one vial in assay buffer 50 mM Tris, pH 8...


US Patent US10421756 (2019)


BindingDB Entry DOI: 10.7270/Q2PK0JGK
More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))
BDBM413921
PNG
(US10421756, Compound 105)
Show SMILES Nc1ccc(cc1NC(=O)N1CC2CCC(C1)O2)-c1ccncc1
Show InChI InChI=1S/C18H20N4O2/c19-16-4-1-13(12-5-7-20-8-6-12)9-17(16)21-18(23)22-10-14-2-3-15(11-22)24-14/h1,4-9,14-15H,2-3,10-11,19H2,(H,21,23)
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Rodin Therapeutics, Inc.

US Patent


Assay Description
HDAC2 containing a C-terminal HIS-Tag (Proteros) and fluorescently-labeled anti-HIS-antibody are diluted in one vial in assay buffer 50 mM Tris, pH 8...


US Patent US10421756 (2019)


BindingDB Entry DOI: 10.7270/Q2PK0JGK
More data for this
Ligand-Target Pair
Histone deacetylase 2


(Homo sapiens (Human))
BDBM413923
PNG
(US10421756, Compound 107 | US10421756, Compound 10...)
Show SMILES CC(=O)N1C2CCC1CN(C2)C(=O)Nc1cc(ccc1N)-c1ccncc1
Show InChI InChI=1S/C20H23N5O2/c1-13(26)25-16-3-4-17(25)12-24(11-16)20(27)23-19-10-15(2-5-18(19)21)14-6-8-22-9-7-14/h2,5-10,16-17H,3-4,11-12,21H2,1H3,(H,23,27)
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n/an/an/a>5.00E+3n/an/an/an/an/a



Rodin Therapeutics, Inc.

US Patent


Assay Description
HDAC2 containing a C-terminal HIS-Tag (Proteros) and fluorescently-labeled anti-HIS-antibody are diluted in one vial in assay buffer 50 mM Tris, pH 8...


US Patent US10421756 (2019)


BindingDB Entry DOI: 10.7270/Q2PK0JGK
More data for this
Ligand-Target Pair
Histone deacetylase 2


(Homo sapiens (Human))
BDBM413931
PNG
(US10421756, Compound 115)
Show SMILES CN1CC2CN(CC2C1=O)C(=O)Nc1cc(ccc1N)-c1ccncc1
Show InChI InChI=1S/C19H21N5O2/c1-23-9-14-10-24(11-15(14)18(23)25)19(26)22-17-8-13(2-3-16(17)20)12-4-6-21-7-5-12/h2-8,14-15H,9-11,20H2,1H3,(H,22,26)
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n/an/an/a 2.75E+3n/an/an/an/an/a



Rodin Therapeutics, Inc.

US Patent


Assay Description
HDAC2 containing a C-terminal HIS-Tag (Proteros) and fluorescently-labeled anti-HIS-antibody are diluted in one vial in assay buffer 50 mM Tris, pH 8...


US Patent US10421756 (2019)


BindingDB Entry DOI: 10.7270/Q2PK0JGK
More data for this
Ligand-Target Pair
Histone deacetylase 2


(Homo sapiens (Human))
BDBM413935
PNG
(US10421756, Compound 119)
Show SMILES Nc1ccc(cc1NC(=O)N1Cc2nccnc2C1)-c1ccc(F)cc1
Show InChI InChI=1S/C19H16FN5O/c20-14-4-1-12(2-5-14)13-3-6-15(21)16(9-13)24-19(26)25-10-17-18(11-25)23-8-7-22-17/h1-9H,10-11,21H2,(H,24,26)
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Rodin Therapeutics, Inc.

US Patent


Assay Description
HDAC2 containing a C-terminal HIS-Tag (Proteros) and fluorescently-labeled anti-HIS-antibody are diluted in one vial in assay buffer 50 mM Tris, pH 8...


US Patent US10421756 (2019)


BindingDB Entry DOI: 10.7270/Q2PK0JGK
More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))
BDBM413959
PNG
(US10421756, Compound 143)
Show SMILES Nc1ccc(cc1NC(=O)N1CCC2(CCN(CCF)C2)CC1)-c1ccc(F)cc1
Show InChI InChI=1S/C23H28F2N4O/c24-10-14-28-11-7-23(16-28)8-12-29(13-9-23)22(30)27-21-15-18(3-6-20(21)26)17-1-4-19(25)5-2-17/h1-6,15H,7-14,16,26H2,(H,27,30)
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Rodin Therapeutics, Inc.

US Patent


Assay Description
HDAC2 containing a C-terminal HIS-Tag (Proteros) and fluorescently-labeled anti-HIS-antibody are diluted in one vial in assay buffer 50 mM Tris, pH 8...


US Patent US10421756 (2019)


BindingDB Entry DOI: 10.7270/Q2PK0JGK
More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))
BDBM413963
PNG
(US10421756, Compound 147)
Show SMILES Nc1ccc(cc1NC(=O)c1nc2CCNCc2s1)-c1ccc(F)cc1
Show InChI InChI=1S/C19H17FN4OS/c20-13-4-1-11(2-5-13)12-3-6-14(21)16(9-12)23-18(25)19-24-15-7-8-22-10-17(15)26-19/h1-6,9,22H,7-8,10,21H2,(H,23,25)
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Rodin Therapeutics, Inc.

US Patent


Assay Description
HDAC2 containing a C-terminal HIS-Tag (Proteros) and fluorescently-labeled anti-HIS-antibody are diluted in one vial in assay buffer 50 mM Tris, pH 8...


US Patent US10421756 (2019)


BindingDB Entry DOI: 10.7270/Q2PK0JGK
More data for this
Ligand-Target Pair
Histone deacetylase 2


(Homo sapiens (Human))
BDBM413964
PNG
(US10421756, Compound 148)
Show SMILES Nc1ccc(cc1NC(=O)N1CC2(C1)CCOCC2)-c1ccc(F)cc1
Show InChI InChI=1S/C20H22FN3O2/c21-16-4-1-14(2-5-16)15-3-6-17(22)18(11-15)23-19(25)24-12-20(13-24)7-9-26-10-8-20/h1-6,11H,7-10,12-13,22H2,(H,23,25)
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Rodin Therapeutics, Inc.

US Patent


Assay Description
HDAC2 containing a C-terminal HIS-Tag (Proteros) and fluorescently-labeled anti-HIS-antibody are diluted in one vial in assay buffer 50 mM Tris, pH 8...


US Patent US10421756 (2019)


BindingDB Entry DOI: 10.7270/Q2PK0JGK
More data for this
Ligand-Target Pair
Histone deacetylase 2


(Homo sapiens (Human))
BDBM413967
PNG
(US10421756, Compound 151)
Show SMILES Nc1ccc(cc1NC(=O)N1Cc2ccncc2C1)-c1ccoc1
Show InChI InChI=1S/C18H16N4O2/c19-16-2-1-12(14-4-6-24-11-14)7-17(16)21-18(23)22-9-13-3-5-20-8-15(13)10-22/h1-8,11H,9-10,19H2,(H,21,23)
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Rodin Therapeutics, Inc.

US Patent


Assay Description
HDAC2 containing a C-terminal HIS-Tag (Proteros) and fluorescently-labeled anti-HIS-antibody are diluted in one vial in assay buffer 50 mM Tris, pH 8...


US Patent US10421756 (2019)


BindingDB Entry DOI: 10.7270/Q2PK0JGK
More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))
BDBM413970
PNG
(US10421756, Compound 154)
Show SMILES COC(=O)N1CC2CN(CC2C1)C(=O)Nc1cc(ccc1N)-c1ccc(F)cc1
Show InChI InChI=1S/C21H23FN4O3/c1-29-21(28)26-11-15-9-25(10-16(15)12-26)20(27)24-19-8-14(4-7-18(19)23)13-2-5-17(22)6-3-13/h2-8,15-16H,9-12,23H2,1H3,(H,24,27)
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Rodin Therapeutics, Inc.

US Patent


Assay Description
HDAC2 containing a C-terminal HIS-Tag (Proteros) and fluorescently-labeled anti-HIS-antibody are diluted in one vial in assay buffer 50 mM Tris, pH 8...


US Patent US10421756 (2019)


BindingDB Entry DOI: 10.7270/Q2PK0JGK
More data for this
Ligand-Target Pair
Histone deacetylase 2


(Homo sapiens (Human))
BDBM413980
PNG
(US10421756, Compound 164)
Show SMILES Nc1ccc(cc1NC(=O)N1CCC2(CCN(C2)C2COC2)CC1)-c1ccc(F)cc1
Show InChI InChI=1S/C24H29FN4O2/c25-19-4-1-17(2-5-19)18-3-6-21(26)22(13-18)27-23(30)28-10-7-24(8-11-28)9-12-29(16-24)20-14-31-15-20/h1-6,13,20H,7-12,14-16,26H2,(H,27,30)
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Rodin Therapeutics, Inc.

US Patent


Assay Description
HDAC2 containing a C-terminal HIS-Tag (Proteros) and fluorescently-labeled anti-HIS-antibody are diluted in one vial in assay buffer 50 mM Tris, pH 8...


US Patent US10421756 (2019)


BindingDB Entry DOI: 10.7270/Q2PK0JGK
More data for this
Ligand-Target Pair
Histone deacetylase 2


(Homo sapiens (Human))
BDBM413988
PNG
(US10421756, Compound 172)
Show SMILES Nc1ccc(cc1NC(=O)N1CCC2(C1)CCOCC2)-c1ccc(F)cc1
Show InChI InChI=1S/C21H24FN3O2/c22-17-4-1-15(2-5-17)16-3-6-18(23)19(13-16)24-20(26)25-10-7-21(14-25)8-11-27-12-9-21/h1-6,13H,7-12,14,23H2,(H,24,26)
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Rodin Therapeutics, Inc.

US Patent


Assay Description
HDAC2 containing a C-terminal HIS-Tag (Proteros) and fluorescently-labeled anti-HIS-antibody are diluted in one vial in assay buffer 50 mM Tris, pH 8...


US Patent US10421756 (2019)


BindingDB Entry DOI: 10.7270/Q2PK0JGK
More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))
BDBM413927
PNG
(US10421756, Compound 111)
Show SMILES Nc1ccc(cc1NC(=O)N1CC2CCC(C1)O2)-c1ccc(F)cc1
Show InChI InChI=1S/C19H20FN3O2/c20-14-4-1-12(2-5-14)13-3-8-17(21)18(9-13)22-19(24)23-10-15-6-7-16(11-23)25-15/h1-5,8-9,15-16H,6-7,10-11,21H2,(H,22,24)
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Rodin Therapeutics, Inc.

US Patent


Assay Description
HDAC2 containing a C-terminal HIS-Tag (Proteros) and fluorescently-labeled anti-HIS-antibody are diluted in one vial in assay buffer 50 mM Tris, pH 8...


US Patent US10421756 (2019)


BindingDB Entry DOI: 10.7270/Q2PK0JGK
More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))
BDBM413932
PNG
(US10421756, Compound 116)
Show SMILES CC(=O)N1C2CCC1CN(C2)C(=O)Nc1cc(ccc1N)-c1ccc(F)cc1
Show InChI InChI=1S/C21H23FN4O2/c1-13(27)26-17-7-8-18(26)12-25(11-17)21(28)24-20-10-15(4-9-19(20)23)14-2-5-16(22)6-3-14/h2-6,9-10,17-18H,7-8,11-12,23H2,1H3,(H,24,28)
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Rodin Therapeutics, Inc.

US Patent


Assay Description
HDAC2 containing a C-terminal HIS-Tag (Proteros) and fluorescently-labeled anti-HIS-antibody are diluted in one vial in assay buffer 50 mM Tris, pH 8...


US Patent US10421756 (2019)


BindingDB Entry DOI: 10.7270/Q2PK0JGK
More data for this
Ligand-Target Pair
Histone deacetylase 2


(Homo sapiens (Human))
BDBM413934
PNG
(US10421756, Compound 118)
Show SMILES Nc1ccc(cc1NC(=O)N1CCC2(CCNC2)CC1)-c1ccc(F)cc1
Show InChI InChI=1S/C21H25FN4O/c22-17-4-1-15(2-5-17)16-3-6-18(23)19(13-16)25-20(27)26-11-8-21(9-12-26)7-10-24-14-21/h1-6,13,24H,7-12,14,23H2,(H,25,27)
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Rodin Therapeutics, Inc.

US Patent


Assay Description
HDAC2 containing a C-terminal HIS-Tag (Proteros) and fluorescently-labeled anti-HIS-antibody are diluted in one vial in assay buffer 50 mM Tris, pH 8...


US Patent US10421756 (2019)


BindingDB Entry DOI: 10.7270/Q2PK0JGK
More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))
BDBM413937
PNG
(US10421756, Compound 121)
Show SMILES NCC(=O)N1CC2CN(CC2C1)C(=O)Nc1cc(ccc1N)-c1ccc(F)cc1
Show InChI InChI=1S/C21H24FN5O2/c22-17-4-1-13(2-5-17)14-3-6-18(24)19(7-14)25-21(29)27-11-15-9-26(20(28)8-23)10-16(15)12-27/h1-7,15-16H,8-12,23-24H2,(H,25,29)
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Rodin Therapeutics, Inc.

US Patent


Assay Description
HDAC2 containing a C-terminal HIS-Tag (Proteros) and fluorescently-labeled anti-HIS-antibody are diluted in one vial in assay buffer 50 mM Tris, pH 8...


US Patent US10421756 (2019)


BindingDB Entry DOI: 10.7270/Q2PK0JGK
More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))
BDBM413938
PNG
(US10421756, Compound 122)
Show SMILES Nc1ccc(cc1NC(=O)c1cn2CCNCc2n1)-c1ccc(F)cc1
Show InChI InChI=1S/C19H18FN5O/c20-14-4-1-12(2-5-14)13-3-6-15(21)16(9-13)24-19(26)17-11-25-8-7-22-10-18(25)23-17/h1-6,9,11,22H,7-8,10,21H2,(H,24,26)
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Rodin Therapeutics, Inc.

US Patent


Assay Description
HDAC2 containing a C-terminal HIS-Tag (Proteros) and fluorescently-labeled anti-HIS-antibody are diluted in one vial in assay buffer 50 mM Tris, pH 8...


US Patent US10421756 (2019)


BindingDB Entry DOI: 10.7270/Q2PK0JGK
More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))
BDBM413939
PNG
(US10421756, Compound 123)
Show SMILES Nc1ccc(cc1NC(=O)c1cn2CCNCc2n1)-c1ccncc1
Show InChI InChI=1S/C18H18N6O/c19-14-2-1-13(12-3-5-20-6-4-12)9-15(14)23-18(25)16-11-24-8-7-21-10-17(24)22-16/h1-6,9,11,21H,7-8,10,19H2,(H,23,25)
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Rodin Therapeutics, Inc.

US Patent


Assay Description
HDAC2 containing a C-terminal HIS-Tag (Proteros) and fluorescently-labeled anti-HIS-antibody are diluted in one vial in assay buffer 50 mM Tris, pH 8...


US Patent US10421756 (2019)


BindingDB Entry DOI: 10.7270/Q2PK0JGK
More data for this
Ligand-Target Pair
Histone deacetylase 2


(Homo sapiens (Human))
BDBM413951
PNG
(US10421756, Compound 135)
Show SMILES Nc1ccc(cc1NC(=O)N1Cc2ccncc2C1)-c1ccc(F)c(F)c1
Show InChI InChI=1S/C20H16F2N4O/c21-16-3-1-12(7-17(16)22)13-2-4-18(23)19(8-13)25-20(27)26-10-14-5-6-24-9-15(14)11-26/h1-9H,10-11,23H2,(H,25,27)
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Rodin Therapeutics, Inc.

US Patent


Assay Description
HDAC2 containing a C-terminal HIS-Tag (Proteros) and fluorescently-labeled anti-HIS-antibody are diluted in one vial in assay buffer 50 mM Tris, pH 8...


US Patent US10421756 (2019)


BindingDB Entry DOI: 10.7270/Q2PK0JGK
More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))
BDBM413954
PNG
(US10421756, Compound 138)
Show SMILES COCCN1CCC2(C1)CCN(CC2)C(=O)Nc1cc(ccc1N)-c1ccc(F)cc1
Show InChI InChI=1S/C24H31FN4O2/c1-31-15-14-28-11-8-24(17-28)9-12-29(13-10-24)23(30)27-22-16-19(4-7-21(22)26)18-2-5-20(25)6-3-18/h2-7,16H,8-15,17,26H2,1H3,(H,27,30)
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Rodin Therapeutics, Inc.

US Patent


Assay Description
HDAC2 containing a C-terminal HIS-Tag (Proteros) and fluorescently-labeled anti-HIS-antibody are diluted in one vial in assay buffer 50 mM Tris, pH 8...


US Patent US10421756 (2019)


BindingDB Entry DOI: 10.7270/Q2PK0JGK
More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))
BDBM413957
PNG
(US10421756, Compound 141)
Show SMILES Cc1cc(F)ccc1-c1ccc(N)c(NC(=O)N2Cc3ccncc3C2)c1
Show InChI InChI=1S/C21H19FN4O/c1-13-8-17(22)3-4-18(13)14-2-5-19(23)20(9-14)25-21(27)26-11-15-6-7-24-10-16(15)12-26/h2-10H,11-12,23H2,1H3,(H,25,27)
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Rodin Therapeutics, Inc.

US Patent


Assay Description
HDAC2 containing a C-terminal HIS-Tag (Proteros) and fluorescently-labeled anti-HIS-antibody are diluted in one vial in assay buffer 50 mM Tris, pH 8...


US Patent US10421756 (2019)


BindingDB Entry DOI: 10.7270/Q2PK0JGK
More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))
BDBM413960
PNG
(US10421756, Compound 144)
Show SMILES Nc1ccc(cc1NC(=O)N1CCC2(CCN(CCF)C2)CC1)-c1ccncc1
Show InChI InChI=1S/C22H28FN5O/c23-8-14-27-11-5-22(16-27)6-12-28(13-7-22)21(29)26-20-15-18(1-2-19(20)24)17-3-9-25-10-4-17/h1-4,9-10,15H,5-8,11-14,16,24H2,(H,26,29)
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Rodin Therapeutics, Inc.

US Patent


Assay Description
HDAC2 containing a C-terminal HIS-Tag (Proteros) and fluorescently-labeled anti-HIS-antibody are diluted in one vial in assay buffer 50 mM Tris, pH 8...


US Patent US10421756 (2019)


BindingDB Entry DOI: 10.7270/Q2PK0JGK
More data for this
Ligand-Target Pair
Histone deacetylase 2


(Homo sapiens (Human))
BDBM413965
PNG
(US10421756, Compound 149)
Show SMILES Nc1ccc(cc1NC(=O)N1Cc2ccncc2C1)-c1ccc(cc1)C#N
Show InChI InChI=1S/C21H17N5O/c22-10-14-1-3-15(4-2-14)16-5-6-19(23)20(9-16)25-21(27)26-12-17-7-8-24-11-18(17)13-26/h1-9,11H,12-13,23H2,(H,25,27)
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Rodin Therapeutics, Inc.

US Patent


Assay Description
HDAC2 containing a C-terminal HIS-Tag (Proteros) and fluorescently-labeled anti-HIS-antibody are diluted in one vial in assay buffer 50 mM Tris, pH 8...


US Patent US10421756 (2019)


BindingDB Entry DOI: 10.7270/Q2PK0JGK
More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))
BDBM413966
PNG
(US10421756, Compound 150)
Show SMILES Nc1ccc(cc1NC(=O)c1cn2CCCCc2n1)-c1ccc(F)cc1
Show InChI InChI=1S/C20H19FN4O/c21-15-7-4-13(5-8-15)14-6-9-16(22)17(11-14)24-20(26)18-12-25-10-2-1-3-19(25)23-18/h4-9,11-12H,1-3,10,22H2,(H,24,26)
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n/an/an/a 300n/an/an/an/an/a



Rodin Therapeutics, Inc.

US Patent


Assay Description
HDAC2 containing a C-terminal HIS-Tag (Proteros) and fluorescently-labeled anti-HIS-antibody are diluted in one vial in assay buffer 50 mM Tris, pH 8...


US Patent US10421756 (2019)


BindingDB Entry DOI: 10.7270/Q2PK0JGK
More data for this
Ligand-Target Pair
Histone deacetylase 2


(Homo sapiens (Human))
BDBM413974
PNG
(US10421756, Compound 158)
Show SMILES Nc1ccc(cc1NC(=O)N1CC2CN(CC2C1)C(=O)OC1CC1)-c1ccc(F)cc1
Show InChI InChI=1S/C23H25FN4O3/c24-18-4-1-14(2-5-18)15-3-8-20(25)21(9-15)26-22(29)27-10-16-12-28(13-17(16)11-27)23(30)31-19-6-7-19/h1-5,8-9,16-17,19H,6-7,10-13,25H2,(H,26,29)
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Rodin Therapeutics, Inc.

US Patent


Assay Description
HDAC2 containing a C-terminal HIS-Tag (Proteros) and fluorescently-labeled anti-HIS-antibody are diluted in one vial in assay buffer 50 mM Tris, pH 8...


US Patent US10421756 (2019)


BindingDB Entry DOI: 10.7270/Q2PK0JGK
More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))
BDBM413978
PNG
(US10421756, Compound 162)
Show SMILES Nc1ccc(cc1NC(=O)N1Cc2ccncc2C1)-c1ccc(OC(F)F)cc1
Show InChI InChI=1S/C21H18F2N4O2/c22-20(23)29-17-4-1-13(2-5-17)14-3-6-18(24)19(9-14)26-21(28)27-11-15-7-8-25-10-16(15)12-27/h1-10,20H,11-12,24H2,(H,26,28)
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Rodin Therapeutics, Inc.

US Patent


Assay Description
HDAC2 containing a C-terminal HIS-Tag (Proteros) and fluorescently-labeled anti-HIS-antibody are diluted in one vial in assay buffer 50 mM Tris, pH 8...


US Patent US10421756 (2019)


BindingDB Entry DOI: 10.7270/Q2PK0JGK
More data for this
Ligand-Target Pair
Histone deacetylase 2


(Homo sapiens (Human))
BDBM413987
PNG
(US10421756, Compound 171)
Show SMILES CC(C)(C)OC(=O)N1CCC2CN(CC2C1)C(=O)Nc1cc(ccc1N)-c1ccc(F)cc1
Show InChI InChI=1S/C25H31FN4O3/c1-25(2,3)33-24(32)29-11-10-18-13-30(15-19(18)14-29)23(31)28-22-12-17(6-9-21(22)27)16-4-7-20(26)8-5-16/h4-9,12,18-19H,10-11,13-15,27H2,1-3H3,(H,28,31)
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Rodin Therapeutics, Inc.

US Patent


Assay Description
HDAC2 containing a C-terminal HIS-Tag (Proteros) and fluorescently-labeled anti-HIS-antibody are diluted in one vial in assay buffer 50 mM Tris, pH 8...


US Patent US10421756 (2019)


BindingDB Entry DOI: 10.7270/Q2PK0JGK
More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))
BDBM413920
PNG
(US10421756, Compound 104)
Show SMILES CC(C)(C)OC(=O)N1CC2CC1CN2C(=O)Nc1cc(ccc1N)-c1ccncc1
Show InChI InChI=1S/C22H27N5O3/c1-22(2,3)30-21(29)27-13-16-11-17(27)12-26(16)20(28)25-19-10-15(4-5-18(19)23)14-6-8-24-9-7-14/h4-10,16-17H,11-13,23H2,1-3H3,(H,25,28)
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Rodin Therapeutics, Inc.

US Patent


Assay Description
HDAC2 containing a C-terminal HIS-Tag (Proteros) and fluorescently-labeled anti-HIS-antibody are diluted in one vial in assay buffer 50 mM Tris, pH 8...


US Patent US10421756 (2019)


BindingDB Entry DOI: 10.7270/Q2PK0JGK
More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))
BDBM413930
PNG
(US10421756, Compound 114)
Show SMILES Nc1ccc(cc1NC(=O)N1CC2CNCC2C1)-c1ccc(F)cc1
Show InChI InChI=1S/C19H21FN4O/c20-16-4-1-12(2-5-16)13-3-6-17(21)18(7-13)23-19(25)24-10-14-8-22-9-15(14)11-24/h1-7,14-15,22H,8-11,21H2,(H,23,25)
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Rodin Therapeutics, Inc.

US Patent


Assay Description
HDAC2 containing a C-terminal HIS-Tag (Proteros) and fluorescently-labeled anti-HIS-antibody are diluted in one vial in assay buffer 50 mM Tris, pH 8...


US Patent US10421756 (2019)


BindingDB Entry DOI: 10.7270/Q2PK0JGK
More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))
BDBM413931
PNG
(US10421756, Compound 115)
Show SMILES CN1CC2CN(CC2C1=O)C(=O)Nc1cc(ccc1N)-c1ccncc1
Show InChI InChI=1S/C19H21N5O2/c1-23-9-14-10-24(11-15(14)18(23)25)19(26)22-17-8-13(2-3-16(17)20)12-4-6-21-7-5-12/h2-8,14-15H,9-11,20H2,1H3,(H,22,26)
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Rodin Therapeutics, Inc.

US Patent


Assay Description
HDAC2 containing a C-terminal HIS-Tag (Proteros) and fluorescently-labeled anti-HIS-antibody are diluted in one vial in assay buffer 50 mM Tris, pH 8...


US Patent US10421756 (2019)


BindingDB Entry DOI: 10.7270/Q2PK0JGK
More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))
BDBM413936
PNG
(US10421756, Compound 120)
Show SMILES CNC(=O)N1CC2CN(CC2C1)C(=O)Nc1cc(ccc1N)-c1ccc(F)cc1
Show InChI InChI=1S/C21H24FN5O2/c1-24-20(28)26-9-15-11-27(12-16(15)10-26)21(29)25-19-8-14(4-7-18(19)23)13-2-5-17(22)6-3-13/h2-8,15-16H,9-12,23H2,1H3,(H,24,28)(H,25,29)
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Rodin Therapeutics, Inc.

US Patent


Assay Description
HDAC2 containing a C-terminal HIS-Tag (Proteros) and fluorescently-labeled anti-HIS-antibody are diluted in one vial in assay buffer 50 mM Tris, pH 8...


US Patent US10421756 (2019)


BindingDB Entry DOI: 10.7270/Q2PK0JGK
More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))
BDBM413940
PNG
(US10421756, Compound 124)
Show SMILES CC(C)(C)OC(=O)N1CC2CN(CC2C1)C(=O)Nc1cc(ccc1N)-c1ccc(F)cc1
Show InChI InChI=1S/C24H29FN4O3/c1-24(2,3)32-23(31)29-13-17-11-28(12-18(17)14-29)22(30)27-21-10-16(6-9-20(21)26)15-4-7-19(25)8-5-15/h4-10,17-18H,11-14,26H2,1-3H3,(H,27,30)
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Rodin Therapeutics, Inc.

US Patent


Assay Description
HDAC2 containing a C-terminal HIS-Tag (Proteros) and fluorescently-labeled anti-HIS-antibody are diluted in one vial in assay buffer 50 mM Tris, pH 8...


US Patent US10421756 (2019)


BindingDB Entry DOI: 10.7270/Q2PK0JGK
More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))
BDBM413941
PNG
(US10421756, Compound 125)
Show SMILES Nc1ccc(cc1NC(=O)N1CC2CN(CC2C1)C(=O)C1CC1)-c1ccc(F)cc1
Show InChI InChI=1S/C23H25FN4O2/c24-19-6-3-14(4-7-19)16-5-8-20(25)21(9-16)26-23(30)28-12-17-10-27(11-18(17)13-28)22(29)15-1-2-15/h3-9,15,17-18H,1-2,10-13,25H2,(H,26,30)
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Rodin Therapeutics, Inc.

US Patent


Assay Description
HDAC2 containing a C-terminal HIS-Tag (Proteros) and fluorescently-labeled anti-HIS-antibody are diluted in one vial in assay buffer 50 mM Tris, pH 8...


US Patent US10421756 (2019)


BindingDB Entry DOI: 10.7270/Q2PK0JGK
More data for this
Ligand-Target Pair
Histone deacetylase 2


(Homo sapiens (Human))
BDBM413943
PNG
(US10421756, Compound 127)
Show SMILES Nc1ccc(cc1NC(=O)N1CCC2(COC2)CC1)-c1ccc(F)cc1
Show InChI InChI=1S/C20H22FN3O2/c21-16-4-1-14(2-5-16)15-3-6-17(22)18(11-15)23-19(25)24-9-7-20(8-10-24)12-26-13-20/h1-6,11H,7-10,12-13,22H2,(H,23,25)
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Rodin Therapeutics, Inc.

US Patent


Assay Description
HDAC2 containing a C-terminal HIS-Tag (Proteros) and fluorescently-labeled anti-HIS-antibody are diluted in one vial in assay buffer 50 mM Tris, pH 8...


US Patent US10421756 (2019)


BindingDB Entry DOI: 10.7270/Q2PK0JGK
More data for this
Ligand-Target Pair
Histone deacetylase 2


(Homo sapiens (Human))
BDBM413950
PNG
(US10421756, Compound 134)
Show SMILES Nc1ccc(cc1NC(=O)N1Cc2ccncc2C1)-c1cccnc1
Show InChI InChI=1S/C19H17N5O/c20-17-4-3-13(14-2-1-6-21-9-14)8-18(17)23-19(25)24-11-15-5-7-22-10-16(15)12-24/h1-10H,11-12,20H2,(H,23,25)
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Rodin Therapeutics, Inc.

US Patent


Assay Description
HDAC2 containing a C-terminal HIS-Tag (Proteros) and fluorescently-labeled anti-HIS-antibody are diluted in one vial in assay buffer 50 mM Tris, pH 8...


US Patent US10421756 (2019)


BindingDB Entry DOI: 10.7270/Q2PK0JGK
More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))
BDBM413950
PNG
(US10421756, Compound 134)
Show SMILES Nc1ccc(cc1NC(=O)N1Cc2ccncc2C1)-c1cccnc1
Show InChI InChI=1S/C19H17N5O/c20-17-4-3-13(14-2-1-6-21-9-14)8-18(17)23-19(25)24-11-15-5-7-22-10-16(15)12-24/h1-10H,11-12,20H2,(H,23,25)
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Rodin Therapeutics, Inc.

US Patent


Assay Description
HDAC2 containing a C-terminal HIS-Tag (Proteros) and fluorescently-labeled anti-HIS-antibody are diluted in one vial in assay buffer 50 mM Tris, pH 8...


US Patent US10421756 (2019)


BindingDB Entry DOI: 10.7270/Q2PK0JGK
More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))
BDBM413952
PNG
(US10421756, Compound 136)
Show SMILES COCCN1CCC2(C1)CCN(CC2)C(=O)Nc1cc(ccc1N)-c1ccncc1
Show InChI InChI=1S/C23H31N5O2/c1-30-15-14-27-11-6-23(17-27)7-12-28(13-8-23)22(29)26-21-16-19(2-3-20(21)24)18-4-9-25-10-5-18/h2-5,9-10,16H,6-8,11-15,17,24H2,1H3,(H,26,29)
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Rodin Therapeutics, Inc.

US Patent


Assay Description
HDAC2 containing a C-terminal HIS-Tag (Proteros) and fluorescently-labeled anti-HIS-antibody are diluted in one vial in assay buffer 50 mM Tris, pH 8...


US Patent US10421756 (2019)


BindingDB Entry DOI: 10.7270/Q2PK0JGK
More data for this
Ligand-Target Pair
Histone deacetylase 2


(Homo sapiens (Human))
BDBM413955
PNG
(US10421756, Compound 139)
Show SMILES COc1ccc(cc1)-c1ccc(N)c(NC(=O)N2Cc3ccncc3C2)c1
Show InChI InChI=1S/C21H20N4O2/c1-27-18-5-2-14(3-6-18)15-4-7-19(22)20(10-15)24-21(26)25-12-16-8-9-23-11-17(16)13-25/h2-11H,12-13,22H2,1H3,(H,24,26)
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Rodin Therapeutics, Inc.

US Patent


Assay Description
HDAC2 containing a C-terminal HIS-Tag (Proteros) and fluorescently-labeled anti-HIS-antibody are diluted in one vial in assay buffer 50 mM Tris, pH 8...


US Patent US10421756 (2019)


BindingDB Entry DOI: 10.7270/Q2PK0JGK
More data for this
Ligand-Target Pair
Histone deacetylase 2


(Homo sapiens (Human))
BDBM413956
PNG
(US10421756, Compound 140)
Show SMILES Nc1ccc(cc1NC(=O)N1Cc2ccncc2C1)-c1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C21H17F3N4O/c22-21(23,24)17-4-1-13(2-5-17)14-3-6-18(25)19(9-14)27-20(29)28-11-15-7-8-26-10-16(15)12-28/h1-10H,11-12,25H2,(H,27,29)
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Rodin Therapeutics, Inc.

US Patent


Assay Description
HDAC2 containing a C-terminal HIS-Tag (Proteros) and fluorescently-labeled anti-HIS-antibody are diluted in one vial in assay buffer 50 mM Tris, pH 8...


US Patent US10421756 (2019)


BindingDB Entry DOI: 10.7270/Q2PK0JGK
More data for this
Ligand-Target Pair
Histone deacetylase 2


(Homo sapiens (Human))
BDBM413958
PNG
(US10421756, Compound 142)
Show SMILES Nc1ccc(cc1NC(=O)N1Cc2ccncc2C1)-c1cc(F)c(F)c(F)c1
Show InChI InChI=1S/C20H15F3N4O/c21-15-5-13(6-16(22)19(15)23)11-1-2-17(24)18(7-11)26-20(28)27-9-12-3-4-25-8-14(12)10-27/h1-8H,9-10,24H2,(H,26,28)
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Rodin Therapeutics, Inc.

US Patent


Assay Description
HDAC2 containing a C-terminal HIS-Tag (Proteros) and fluorescently-labeled anti-HIS-antibody are diluted in one vial in assay buffer 50 mM Tris, pH 8...


US Patent US10421756 (2019)


BindingDB Entry DOI: 10.7270/Q2PK0JGK
More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))
BDBM413961
PNG
(US10421756, Compound 145)
Show SMILES Cn1cc(cn1)-c1ccc(N)c(NC(=O)N2Cc3ccncc3C2)c1
Show InChI InChI=1S/C18H18N6O/c1-23-9-15(8-21-23)12-2-3-16(19)17(6-12)22-18(25)24-10-13-4-5-20-7-14(13)11-24/h2-9H,10-11,19H2,1H3,(H,22,25)
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Rodin Therapeutics, Inc.

US Patent


Assay Description
HDAC2 containing a C-terminal HIS-Tag (Proteros) and fluorescently-labeled anti-HIS-antibody are diluted in one vial in assay buffer 50 mM Tris, pH 8...


US Patent US10421756 (2019)


BindingDB Entry DOI: 10.7270/Q2PK0JGK
More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))
BDBM413965
PNG
(US10421756, Compound 149)
Show SMILES Nc1ccc(cc1NC(=O)N1Cc2ccncc2C1)-c1ccc(cc1)C#N
Show InChI InChI=1S/C21H17N5O/c22-10-14-1-3-15(4-2-14)16-5-6-19(23)20(9-16)25-21(27)26-12-17-7-8-24-11-18(17)13-26/h1-9,11H,12-13,23H2,(H,25,27)
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Rodin Therapeutics, Inc.

US Patent


Assay Description
HDAC2 containing a C-terminal HIS-Tag (Proteros) and fluorescently-labeled anti-HIS-antibody are diluted in one vial in assay buffer 50 mM Tris, pH 8...


US Patent US10421756 (2019)


BindingDB Entry DOI: 10.7270/Q2PK0JGK
More data for this
Ligand-Target Pair
Histone deacetylase 2


(Homo sapiens (Human))
BDBM413966
PNG
(US10421756, Compound 150)
Show SMILES Nc1ccc(cc1NC(=O)c1cn2CCCCc2n1)-c1ccc(F)cc1
Show InChI InChI=1S/C20H19FN4O/c21-15-7-4-13(5-8-15)14-6-9-16(22)17(11-14)24-20(26)18-12-25-10-2-1-3-19(25)23-18/h4-9,11-12H,1-3,10,22H2,(H,24,26)
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n/an/an/a 2.75E+3n/an/an/an/an/a



Rodin Therapeutics, Inc.

US Patent


Assay Description
HDAC2 containing a C-terminal HIS-Tag (Proteros) and fluorescently-labeled anti-HIS-antibody are diluted in one vial in assay buffer 50 mM Tris, pH 8...


US Patent US10421756 (2019)


BindingDB Entry DOI: 10.7270/Q2PK0JGK
More data for this
Ligand-Target Pair
Histone deacetylase 2


(Homo sapiens (Human))
BDBM413972
PNG
(US10421756, Compound 156)
Show SMILES CC(C)OC(=O)N1CC2CN(CC2C1)C(=O)Nc1cc(ccc1N)-c1ccc(F)cc1
Show InChI InChI=1S/C23H27FN4O3/c1-14(2)31-23(30)28-12-17-10-27(11-18(17)13-28)22(29)26-21-9-16(5-8-20(21)25)15-3-6-19(24)7-4-15/h3-9,14,17-18H,10-13,25H2,1-2H3,(H,26,29)
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Rodin Therapeutics, Inc.

US Patent


Assay Description
HDAC2 containing a C-terminal HIS-Tag (Proteros) and fluorescently-labeled anti-HIS-antibody are diluted in one vial in assay buffer 50 mM Tris, pH 8...


US Patent US10421756 (2019)


BindingDB Entry DOI: 10.7270/Q2PK0JGK
More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))
BDBM413973
PNG
(US10421756, Compound 157)
Show SMILES CC(C)COC(=O)N1CC2CN(CC2C1)C(=O)Nc1cc(ccc1N)-c1ccc(F)cc1
Show InChI InChI=1S/C24H29FN4O3/c1-15(2)14-32-24(31)29-12-18-10-28(11-19(18)13-29)23(30)27-22-9-17(5-8-21(22)26)16-3-6-20(25)7-4-16/h3-9,15,18-19H,10-14,26H2,1-2H3,(H,27,30)
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Rodin Therapeutics, Inc.

US Patent


Assay Description
HDAC2 containing a C-terminal HIS-Tag (Proteros) and fluorescently-labeled anti-HIS-antibody are diluted in one vial in assay buffer 50 mM Tris, pH 8...


US Patent US10421756 (2019)


BindingDB Entry DOI: 10.7270/Q2PK0JGK
More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))
BDBM413976
PNG
(US10421756, Compound 160)
Show SMILES CC(C)CC(=O)N1CC2CN(CC2C1)C(=O)Nc1cc(ccc1N)-c1ccc(F)cc1
Show InChI InChI=1S/C24H29FN4O2/c1-15(2)9-23(30)28-11-18-13-29(14-19(18)12-28)24(31)27-22-10-17(5-8-21(22)26)16-3-6-20(25)7-4-16/h3-8,10,15,18-19H,9,11-14,26H2,1-2H3,(H,27,31)
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Rodin Therapeutics, Inc.

US Patent


Assay Description
HDAC2 containing a C-terminal HIS-Tag (Proteros) and fluorescently-labeled anti-HIS-antibody are diluted in one vial in assay buffer 50 mM Tris, pH 8...


US Patent US10421756 (2019)


BindingDB Entry DOI: 10.7270/Q2PK0JGK
More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))
BDBM413977
PNG
(US10421756, Compound 161)
Show SMILES CC(C)(C)OC(=O)N1CCC2(C1)CCN(CC2)C(=O)Nc1cc(ccc1N)-c1ccc(F)cc1
Show InChI InChI=1S/C26H33FN4O3/c1-25(2,3)34-24(33)31-15-12-26(17-31)10-13-30(14-11-26)23(32)29-22-16-19(6-9-21(22)28)18-4-7-20(27)8-5-18/h4-9,16H,10-15,17,28H2,1-3H3,(H,29,32)
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Rodin Therapeutics, Inc.

US Patent


Assay Description
HDAC2 containing a C-terminal HIS-Tag (Proteros) and fluorescently-labeled anti-HIS-antibody are diluted in one vial in assay buffer 50 mM Tris, pH 8...


US Patent US10421756 (2019)


BindingDB Entry DOI: 10.7270/Q2PK0JGK
More data for this
Ligand-Target Pair
Histone deacetylase 2


(Homo sapiens (Human))
BDBM413981
PNG
(US10421756, Compound 165)
Show SMILES Nc1ccc(cc1NC(=O)N1CCC2(CCN(C2)C2COC2)CC1)-c1ccncc1
Show InChI InChI=1S/C23H29N5O2/c24-20-2-1-18(17-3-8-25-9-4-17)13-21(20)26-22(29)27-10-5-23(6-11-27)7-12-28(16-23)19-14-30-15-19/h1-4,8-9,13,19H,5-7,10-12,14-16,24H2,(H,26,29)
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Rodin Therapeutics, Inc.

US Patent


Assay Description
HDAC2 containing a C-terminal HIS-Tag (Proteros) and fluorescently-labeled anti-HIS-antibody are diluted in one vial in assay buffer 50 mM Tris, pH 8...


US Patent US10421756 (2019)


BindingDB Entry DOI: 10.7270/Q2PK0JGK
More data for this
Ligand-Target Pair
Histone deacetylase 2


(Homo sapiens (Human))
BDBM413917
PNG
(US10421756, Compound 101)
Show SMILES Nc1ccc(cc1NC(=O)N1Cc2nccnc2C1)-c1ccncc1
Show InChI InChI=1S/C18H16N6O/c19-14-2-1-13(12-3-5-20-6-4-12)9-15(14)23-18(25)24-10-16-17(11-24)22-8-7-21-16/h1-9H,10-11,19H2,(H,23,25)
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Rodin Therapeutics, Inc.

US Patent


Assay Description
HDAC2 containing a C-terminal HIS-Tag (Proteros) and fluorescently-labeled anti-HIS-antibody are diluted in one vial in assay buffer 50 mM Tris, pH 8...


US Patent US10421756 (2019)


BindingDB Entry DOI: 10.7270/Q2PK0JGK
More data for this
Ligand-Target Pair
Histone deacetylase 2


(Homo sapiens (Human))
BDBM413919
PNG
(US10421756, Compound 103)
Show SMILES Nc1ccc(cc1NC(=O)N1Cc2ccncc2C1)-c1ccncn1
Show InChI InChI=1S/C18H16N6O/c19-15-2-1-12(16-4-6-21-11-22-16)7-17(15)23-18(25)24-9-13-3-5-20-8-14(13)10-24/h1-8,11H,9-10,19H2,(H,23,25)
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Rodin Therapeutics, Inc.

US Patent


Assay Description
HDAC2 containing a C-terminal HIS-Tag (Proteros) and fluorescently-labeled anti-HIS-antibody are diluted in one vial in assay buffer 50 mM Tris, pH 8...


US Patent US10421756 (2019)


BindingDB Entry DOI: 10.7270/Q2PK0JGK
More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))
BDBM413923
PNG
(US10421756, Compound 107 | US10421756, Compound 10...)
Show SMILES CC(=O)N1C2CCC1CN(C2)C(=O)Nc1cc(ccc1N)-c1ccncc1
Show InChI InChI=1S/C20H23N5O2/c1-13(26)25-16-3-4-17(25)12-24(11-16)20(27)23-19-10-15(2-5-18(19)21)14-6-8-22-9-7-14/h2,5-10,16-17H,3-4,11-12,21H2,1H3,(H,23,27)
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Rodin Therapeutics, Inc.

US Patent


Assay Description
HDAC2 containing a C-terminal HIS-Tag (Proteros) and fluorescently-labeled anti-HIS-antibody are diluted in one vial in assay buffer 50 mM Tris, pH 8...


US Patent US10421756 (2019)


BindingDB Entry DOI: 10.7270/Q2PK0JGK
More data for this
Ligand-Target Pair
Histone deacetylase 2


(Homo sapiens (Human))
BDBM413923
PNG
(US10421756, Compound 107 | US10421756, Compound 10...)
Show SMILES CC(=O)N1C2CCC1CN(C2)C(=O)Nc1cc(ccc1N)-c1ccncc1
Show InChI InChI=1S/C20H23N5O2/c1-13(26)25-16-3-4-17(25)12-24(11-16)20(27)23-19-10-15(2-5-18(19)21)14-6-8-22-9-7-14/h2,5-10,16-17H,3-4,11-12,21H2,1H3,(H,23,27)
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Rodin Therapeutics, Inc.

US Patent


Assay Description
HDAC2 containing a C-terminal HIS-Tag (Proteros) and fluorescently-labeled anti-HIS-antibody are diluted in one vial in assay buffer 50 mM Tris, pH 8...


US Patent US10421756 (2019)


BindingDB Entry DOI: 10.7270/Q2PK0JGK
More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))
BDBM413923
PNG
(US10421756, Compound 107 | US10421756, Compound 10...)
Show SMILES CC(=O)N1C2CCC1CN(C2)C(=O)Nc1cc(ccc1N)-c1ccncc1
Show InChI InChI=1S/C20H23N5O2/c1-13(26)25-16-3-4-17(25)12-24(11-16)20(27)23-19-10-15(2-5-18(19)21)14-6-8-22-9-7-14/h2,5-10,16-17H,3-4,11-12,21H2,1H3,(H,23,27)
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Rodin Therapeutics, Inc.

US Patent


Assay Description
HDAC2 containing a C-terminal HIS-Tag (Proteros) and fluorescently-labeled anti-HIS-antibody are diluted in one vial in assay buffer 50 mM Tris, pH 8...


US Patent US10421756 (2019)


BindingDB Entry DOI: 10.7270/Q2PK0JGK
More data for this
Ligand-Target Pair
Histone deacetylase 2


(Homo sapiens (Human))
BDBM413927
PNG
(US10421756, Compound 111)
Show SMILES Nc1ccc(cc1NC(=O)N1CC2CCC(C1)O2)-c1ccc(F)cc1
Show InChI InChI=1S/C19H20FN3O2/c20-14-4-1-12(2-5-14)13-3-8-17(21)18(9-13)22-19(24)23-10-15-6-7-16(11-23)25-15/h1-5,8-9,15-16H,6-7,10-11,21H2,(H,22,24)
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Rodin Therapeutics, Inc.

US Patent


Assay Description
HDAC2 containing a C-terminal HIS-Tag (Proteros) and fluorescently-labeled anti-HIS-antibody are diluted in one vial in assay buffer 50 mM Tris, pH 8...


US Patent US10421756 (2019)


BindingDB Entry DOI: 10.7270/Q2PK0JGK
More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))
BDBM413928
PNG
(US10421756, Compound 112)
Show SMILES CC(C)(C)OC(=O)N1C2CCC1CN(C2)C(=O)Nc1cc(ccc1N)-c1ccc(F)cc1
Show InChI InChI=1S/C24H29FN4O3/c1-24(2,3)32-23(31)29-18-9-10-19(29)14-28(13-18)22(30)27-21-12-16(6-11-20(21)26)15-4-7-17(25)8-5-15/h4-8,11-12,18-19H,9-10,13-14,26H2,1-3H3,(H,27,30)
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Rodin Therapeutics, Inc.

US Patent


Assay Description
HDAC2 containing a C-terminal HIS-Tag (Proteros) and fluorescently-labeled anti-HIS-antibody are diluted in one vial in assay buffer 50 mM Tris, pH 8...


US Patent US10421756 (2019)


BindingDB Entry DOI: 10.7270/Q2PK0JGK
More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))
BDBM413929
PNG
(US10421756, Compound 113)
Show SMILES Nc1ccc(cc1NC(=O)N1CC2CCC(C1)N2)-c1ccc(F)cc1
Show InChI InChI=1S/C19H21FN4O/c20-14-4-1-12(2-5-14)13-3-8-17(21)18(9-13)23-19(25)24-10-15-6-7-16(11-24)22-15/h1-5,8-9,15-16,22H,6-7,10-11,21H2,(H,23,25)
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Rodin Therapeutics, Inc.

US Patent


Assay Description
HDAC2 containing a C-terminal HIS-Tag (Proteros) and fluorescently-labeled anti-HIS-antibody are diluted in one vial in assay buffer 50 mM Tris, pH 8...


US Patent US10421756 (2019)


BindingDB Entry DOI: 10.7270/Q2PK0JGK
More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))
BDBM413933
PNG
(US10421756, Compound 117)
Show SMILES Nc1ccc(cc1NC(=O)N1CC2CCC(C1)N2C=O)-c1ccc(F)cc1
Show InChI InChI=1S/C20H21FN4O2/c21-15-4-1-13(2-5-15)14-3-8-18(22)19(9-14)23-20(27)24-10-16-6-7-17(11-24)25(16)12-26/h1-5,8-9,12,16-17H,6-7,10-11,22H2,(H,23,27)
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Rodin Therapeutics, Inc.

US Patent


Assay Description
HDAC2 containing a C-terminal HIS-Tag (Proteros) and fluorescently-labeled anti-HIS-antibody are diluted in one vial in assay buffer 50 mM Tris, pH 8...


US Patent US10421756 (2019)


BindingDB Entry DOI: 10.7270/Q2PK0JGK
More data for this
Ligand-Target Pair
Histone deacetylase 2


(Homo sapiens (Human))
BDBM413936
PNG
(US10421756, Compound 120)
Show SMILES CNC(=O)N1CC2CN(CC2C1)C(=O)Nc1cc(ccc1N)-c1ccc(F)cc1
Show InChI InChI=1S/C21H24FN5O2/c1-24-20(28)26-9-15-11-27(12-16(15)10-26)21(29)25-19-8-14(4-7-18(19)23)13-2-5-17(22)6-3-13/h2-8,15-16H,9-12,23H2,1H3,(H,24,28)(H,25,29)
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Rodin Therapeutics, Inc.

US Patent


Assay Description
HDAC2 containing a C-terminal HIS-Tag (Proteros) and fluorescently-labeled anti-HIS-antibody are diluted in one vial in assay buffer 50 mM Tris, pH 8...


US Patent US10421756 (2019)


BindingDB Entry DOI: 10.7270/Q2PK0JGK
More data for this
Ligand-Target Pair
Histone deacetylase 2


(Homo sapiens (Human))
BDBM413937
PNG
(US10421756, Compound 121)
Show SMILES NCC(=O)N1CC2CN(CC2C1)C(=O)Nc1cc(ccc1N)-c1ccc(F)cc1
Show InChI InChI=1S/C21H24FN5O2/c22-17-4-1-13(2-5-17)14-3-6-18(24)19(7-14)25-21(29)27-11-15-9-26(20(28)8-23)10-16(15)12-27/h1-7,15-16H,8-12,23-24H2,(H,25,29)
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Rodin Therapeutics, Inc.

US Patent


Assay Description
HDAC2 containing a C-terminal HIS-Tag (Proteros) and fluorescently-labeled anti-HIS-antibody are diluted in one vial in assay buffer 50 mM Tris, pH 8...


US Patent US10421756 (2019)


BindingDB Entry DOI: 10.7270/Q2PK0JGK
More data for this
Ligand-Target Pair
Histone deacetylase 2


(Homo sapiens (Human))
BDBM413939
PNG
(US10421756, Compound 123)
Show SMILES Nc1ccc(cc1NC(=O)c1cn2CCNCc2n1)-c1ccncc1
Show InChI InChI=1S/C18H18N6O/c19-14-2-1-13(12-3-5-20-6-4-12)9-15(14)23-18(25)16-11-24-8-7-21-10-17(24)22-16/h1-6,9,11,21H,7-8,10,19H2,(H,23,25)
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Rodin Therapeutics, Inc.

US Patent


Assay Description
HDAC2 containing a C-terminal HIS-Tag (Proteros) and fluorescently-labeled anti-HIS-antibody are diluted in one vial in assay buffer 50 mM Tris, pH 8...


US Patent US10421756 (2019)


BindingDB Entry DOI: 10.7270/Q2PK0JGK
More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))
BDBM413942
PNG
(US10421756, Compound 126)
Show SMILES Nc1ccc(cc1NC(=O)N1CC2CN(CC2C1)C1COC1)-c1ccc(F)cc1
Show InChI InChI=1S/C22H25FN4O2/c23-18-4-1-14(2-5-18)15-3-6-20(24)21(7-15)25-22(28)27-10-16-8-26(9-17(16)11-27)19-12-29-13-19/h1-7,16-17,19H,8-13,24H2,(H,25,28)
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Rodin Therapeutics, Inc.

US Patent


Assay Description
HDAC2 containing a C-terminal HIS-Tag (Proteros) and fluorescently-labeled anti-HIS-antibody are diluted in one vial in assay buffer 50 mM Tris, pH 8...


US Patent US10421756 (2019)


BindingDB Entry DOI: 10.7270/Q2PK0JGK
More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))
BDBM413946
PNG
(US10421756, Compound 130)
Show SMILES Nc1ccc(cc1NC(=O)N1Cc2ccncc2C1)-c1ccc(Cl)cc1
Show InChI InChI=1S/C20H17ClN4O/c21-17-4-1-13(2-5-17)14-3-6-18(22)19(9-14)24-20(26)25-11-15-7-8-23-10-16(15)12-25/h1-10H,11-12,22H2,(H,24,26)
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Rodin Therapeutics, Inc.

US Patent


Assay Description
HDAC2 containing a C-terminal HIS-Tag (Proteros) and fluorescently-labeled anti-HIS-antibody are diluted in one vial in assay buffer 50 mM Tris, pH 8...


US Patent US10421756 (2019)


BindingDB Entry DOI: 10.7270/Q2PK0JGK
More data for this
Ligand-Target Pair
Histone deacetylase 2


(Homo sapiens (Human))
BDBM413948
PNG
(US10421756, Compound 132)
Show SMILES Nc1ccc(cc1NC(=O)N1Cc2ccncc2C1)-c1ccc(cc1F)C(F)(F)F
Show InChI InChI=1S/C21H16F4N4O/c22-17-8-15(21(23,24)25)2-3-16(17)12-1-4-18(26)19(7-12)28-20(30)29-10-13-5-6-27-9-14(13)11-29/h1-9H,10-11,26H2,(H,28,30)
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n/an/an/a 2.75E+3n/an/an/an/an/a



Rodin Therapeutics, Inc.

US Patent


Assay Description
HDAC2 containing a C-terminal HIS-Tag (Proteros) and fluorescently-labeled anti-HIS-antibody are diluted in one vial in assay buffer 50 mM Tris, pH 8...


US Patent US10421756 (2019)


BindingDB Entry DOI: 10.7270/Q2PK0JGK
More data for this
Ligand-Target Pair
Histone deacetylase 2


(Homo sapiens (Human))
BDBM413959
PNG
(US10421756, Compound 143)
Show SMILES Nc1ccc(cc1NC(=O)N1CCC2(CCN(CCF)C2)CC1)-c1ccc(F)cc1
Show InChI InChI=1S/C23H28F2N4O/c24-10-14-28-11-7-23(16-28)8-12-29(13-9-23)22(30)27-21-15-18(3-6-20(21)26)17-1-4-19(25)5-2-17/h1-6,15H,7-14,16,26H2,(H,27,30)
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Rodin Therapeutics, Inc.

US Patent


Assay Description
HDAC2 containing a C-terminal HIS-Tag (Proteros) and fluorescently-labeled anti-HIS-antibody are diluted in one vial in assay buffer 50 mM Tris, pH 8...


US Patent US10421756 (2019)


BindingDB Entry DOI: 10.7270/Q2PK0JGK
More data for this
Ligand-Target Pair
Histone deacetylase 2


(Homo sapiens (Human))
BDBM413960
PNG
(US10421756, Compound 144)
Show SMILES Nc1ccc(cc1NC(=O)N1CCC2(CCN(CCF)C2)CC1)-c1ccncc1
Show InChI InChI=1S/C22H28FN5O/c23-8-14-27-11-5-22(16-27)6-12-28(13-7-22)21(29)26-20-15-18(1-2-19(20)24)17-3-9-25-10-4-17/h1-4,9-10,15H,5-8,11-14,16,24H2,(H,26,29)
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Rodin Therapeutics, Inc.

US Patent


Assay Description
HDAC2 containing a C-terminal HIS-Tag (Proteros) and fluorescently-labeled anti-HIS-antibody are diluted in one vial in assay buffer 50 mM Tris, pH 8...


US Patent US10421756 (2019)


BindingDB Entry DOI: 10.7270/Q2PK0JGK
More data for this
Ligand-Target Pair
Histone deacetylase 2


(Homo sapiens (Human))
BDBM413961
PNG
(US10421756, Compound 145)
Show SMILES Cn1cc(cn1)-c1ccc(N)c(NC(=O)N2Cc3ccncc3C2)c1
Show InChI InChI=1S/C18H18N6O/c1-23-9-15(8-21-23)12-2-3-16(19)17(6-12)22-18(25)24-10-13-4-5-20-7-14(13)11-24/h2-9H,10-11,19H2,1H3,(H,22,25)
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Rodin Therapeutics, Inc.

US Patent


Assay Description
HDAC2 containing a C-terminal HIS-Tag (Proteros) and fluorescently-labeled anti-HIS-antibody are diluted in one vial in assay buffer 50 mM Tris, pH 8...


US Patent US10421756 (2019)


BindingDB Entry DOI: 10.7270/Q2PK0JGK
More data for this
Ligand-Target Pair
Histone deacetylase 2


(Homo sapiens (Human))
BDBM413962
PNG
(US10421756, Compound 146)
Show SMILES Nc1ccc(cc1NC(=O)N1Cc2ccncc2C1)-c1ccccn1
Show InChI InChI=1S/C19H17N5O/c20-16-5-4-13(17-3-1-2-7-22-17)9-18(16)23-19(25)24-11-14-6-8-21-10-15(14)12-24/h1-10H,11-12,20H2,(H,23,25)
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Rodin Therapeutics, Inc.

US Patent


Assay Description
HDAC2 containing a C-terminal HIS-Tag (Proteros) and fluorescently-labeled anti-HIS-antibody are diluted in one vial in assay buffer 50 mM Tris, pH 8...


US Patent US10421756 (2019)


BindingDB Entry DOI: 10.7270/Q2PK0JGK
More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))
BDBM413962
PNG
(US10421756, Compound 146)
Show SMILES Nc1ccc(cc1NC(=O)N1Cc2ccncc2C1)-c1ccccn1
Show InChI InChI=1S/C19H17N5O/c20-16-5-4-13(17-3-1-2-7-22-17)9-18(16)23-19(25)24-11-14-6-8-21-10-15(14)12-24/h1-10H,11-12,20H2,(H,23,25)
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Rodin Therapeutics, Inc.

US Patent


Assay Description
HDAC2 containing a C-terminal HIS-Tag (Proteros) and fluorescently-labeled anti-HIS-antibody are diluted in one vial in assay buffer 50 mM Tris, pH 8...


US Patent US10421756 (2019)


BindingDB Entry DOI: 10.7270/Q2PK0JGK
More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))
BDBM413968
PNG
(US10421756, Compound 152)
Show SMILES CNC(=O)N1CCc2nc(sc2C1)C(=O)Nc1cc(ccc1N)-c1ccc(F)cc1
Show InChI InChI=1S/C21H20FN5O2S/c1-24-21(29)27-9-8-16-18(11-27)30-20(26-16)19(28)25-17-10-13(4-7-15(17)23)12-2-5-14(22)6-3-12/h2-7,10H,8-9,11,23H2,1H3,(H,24,29)(H,25,28)
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Rodin Therapeutics, Inc.

US Patent


Assay Description
HDAC2 containing a C-terminal HIS-Tag (Proteros) and fluorescently-labeled anti-HIS-antibody are diluted in one vial in assay buffer 50 mM Tris, pH 8...


US Patent US10421756 (2019)


BindingDB Entry DOI: 10.7270/Q2PK0JGK
More data for this
Ligand-Target Pair
Histone deacetylase 2


(Homo sapiens (Human))
BDBM413970
PNG
(US10421756, Compound 154)
Show SMILES COC(=O)N1CC2CN(CC2C1)C(=O)Nc1cc(ccc1N)-c1ccc(F)cc1
Show InChI InChI=1S/C21H23FN4O3/c1-29-21(28)26-11-15-9-25(10-16(15)12-26)20(27)24-19-8-14(4-7-18(19)23)13-2-5-17(22)6-3-13/h2-8,15-16H,9-12,23H2,1H3,(H,24,27)
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Rodin Therapeutics, Inc.

US Patent


Assay Description
HDAC2 containing a C-terminal HIS-Tag (Proteros) and fluorescently-labeled anti-HIS-antibody are diluted in one vial in assay buffer 50 mM Tris, pH 8...


US Patent US10421756 (2019)


BindingDB Entry DOI: 10.7270/Q2PK0JGK
More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))
BDBM413972
PNG
(US10421756, Compound 156)
Show SMILES CC(C)OC(=O)N1CC2CN(CC2C1)C(=O)Nc1cc(ccc1N)-c1ccc(F)cc1
Show InChI InChI=1S/C23H27FN4O3/c1-14(2)31-23(30)28-12-17-10-27(11-18(17)13-28)22(29)26-21-9-16(5-8-20(21)25)15-3-6-19(24)7-4-15/h3-9,14,17-18H,10-13,25H2,1-2H3,(H,26,29)
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Rodin Therapeutics, Inc.

US Patent


Assay Description
HDAC2 containing a C-terminal HIS-Tag (Proteros) and fluorescently-labeled anti-HIS-antibody are diluted in one vial in assay buffer 50 mM Tris, pH 8...


US Patent US10421756 (2019)


BindingDB Entry DOI: 10.7270/Q2PK0JGK
More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))
BDBM413975
PNG
(US10421756, Compound 159)
Show SMILES Nc1ccc(cc1NC(=O)N1CC2CN(CC2C1)C(=O)OC1CCC1)-c1ccc(F)cc1
Show InChI InChI=1S/C24H27FN4O3/c25-19-7-4-15(5-8-19)16-6-9-21(26)22(10-16)27-23(30)28-11-17-13-29(14-18(17)12-28)24(31)32-20-2-1-3-20/h4-10,17-18,20H,1-3,11-14,26H2,(H,27,30)
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Rodin Therapeutics, Inc.

US Patent


Assay Description
HDAC2 containing a C-terminal HIS-Tag (Proteros) and fluorescently-labeled anti-HIS-antibody are diluted in one vial in assay buffer 50 mM Tris, pH 8...


US Patent US10421756 (2019)


BindingDB Entry DOI: 10.7270/Q2PK0JGK
More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))
BDBM413980
PNG
(US10421756, Compound 164)
Show SMILES Nc1ccc(cc1NC(=O)N1CCC2(CCN(C2)C2COC2)CC1)-c1ccc(F)cc1
Show InChI InChI=1S/C24H29FN4O2/c25-19-4-1-17(2-5-19)18-3-6-21(26)22(13-18)27-23(30)28-10-7-24(8-11-28)9-12-29(16-24)20-14-31-15-20/h1-6,13,20H,7-12,14-16,26H2,(H,27,30)
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Rodin Therapeutics, Inc.

US Patent


Assay Description
HDAC2 containing a C-terminal HIS-Tag (Proteros) and fluorescently-labeled anti-HIS-antibody are diluted in one vial in assay buffer 50 mM Tris, pH 8...


US Patent US10421756 (2019)


BindingDB Entry DOI: 10.7270/Q2PK0JGK
More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))
BDBM413981
PNG
(US10421756, Compound 165)
Show SMILES Nc1ccc(cc1NC(=O)N1CCC2(CCN(C2)C2COC2)CC1)-c1ccncc1
Show InChI InChI=1S/C23H29N5O2/c24-20-2-1-18(17-3-8-25-9-4-17)13-21(20)26-22(29)27-10-5-23(6-11-27)7-12-28(16-23)19-14-30-15-19/h1-4,8-9,13,19H,5-7,10-12,14-16,24H2,(H,26,29)
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Rodin Therapeutics, Inc.

US Patent


Assay Description
HDAC2 containing a C-terminal HIS-Tag (Proteros) and fluorescently-labeled anti-HIS-antibody are diluted in one vial in assay buffer 50 mM Tris, pH 8...


US Patent US10421756 (2019)


BindingDB Entry DOI: 10.7270/Q2PK0JGK
More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))
BDBM413983
PNG
(US10421756, Compound 167)
Show SMILES Nc1ccc(cc1NC(=O)N1Cc2ccncc2C1)-c1ccc(cn1)C(F)(F)F
Show InChI InChI=1S/C20H16F3N5O/c21-20(22,23)15-2-4-17(26-9-15)12-1-3-16(24)18(7-12)27-19(29)28-10-13-5-6-25-8-14(13)11-28/h1-9H,10-11,24H2,(H,27,29)
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Rodin Therapeutics, Inc.

US Patent


Assay Description
HDAC2 containing a C-terminal HIS-Tag (Proteros) and fluorescently-labeled anti-HIS-antibody are diluted in one vial in assay buffer 50 mM Tris, pH 8...


US Patent US10421756 (2019)


BindingDB Entry DOI: 10.7270/Q2PK0JGK
More data for this
Ligand-Target Pair
Histone deacetylase 2


(Homo sapiens (Human))
BDBM413984
PNG
(US10421756, Compound 168)
Show SMILES Nc1ccc(cc1NC(=O)N1Cc2ccncc2C1)-c1ccco1
Show InChI InChI=1S/C18H16N4O2/c19-15-4-3-12(17-2-1-7-24-17)8-16(15)21-18(23)22-10-13-5-6-20-9-14(13)11-22/h1-9H,10-11,19H2,(H,21,23)
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Rodin Therapeutics, Inc.

US Patent


Assay Description
HDAC2 containing a C-terminal HIS-Tag (Proteros) and fluorescently-labeled anti-HIS-antibody are diluted in one vial in assay buffer 50 mM Tris, pH 8...


US Patent US10421756 (2019)


BindingDB Entry DOI: 10.7270/Q2PK0JGK
More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))
BDBM413985
PNG
(US10421756, Compound 169)
Show SMILES Nc1ccc(cc1NC(=O)N1CC2(C1)CCNCC2)-c1ccc(F)cc1
Show InChI InChI=1S/C20H23FN4O/c21-16-4-1-14(2-5-16)15-3-6-17(22)18(11-15)24-19(26)25-12-20(13-25)7-9-23-10-8-20/h1-6,11,23H,7-10,12-13,22H2,(H,24,26)
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Rodin Therapeutics, Inc.

US Patent


Assay Description
HDAC2 containing a C-terminal HIS-Tag (Proteros) and fluorescently-labeled anti-HIS-antibody are diluted in one vial in assay buffer 50 mM Tris, pH 8...


US Patent US10421756 (2019)


BindingDB Entry DOI: 10.7270/Q2PK0JGK
More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))
BDBM413988
PNG
(US10421756, Compound 172)
Show SMILES Nc1ccc(cc1NC(=O)N1CCC2(C1)CCOCC2)-c1ccc(F)cc1
Show InChI InChI=1S/C21H24FN3O2/c22-17-4-1-15(2-5-17)16-3-6-18(23)19(13-16)24-20(26)25-10-7-21(14-25)8-11-27-12-9-21/h1-6,13H,7-12,14,23H2,(H,24,26)
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Rodin Therapeutics, Inc.

US Patent


Assay Description
HDAC2 containing a C-terminal HIS-Tag (Proteros) and fluorescently-labeled anti-HIS-antibody are diluted in one vial in assay buffer 50 mM Tris, pH 8...


US Patent US10421756 (2019)


BindingDB Entry DOI: 10.7270/Q2PK0JGK
More data for this
Ligand-Target Pair
Histone deacetylase 2


(Homo sapiens (Human))
BDBM413991
PNG
(US10421756, Compound 175)
Show SMILES Nc1ccc(cc1NC(=O)c1nc2CNCCc2s1)-c1ccc(F)cc1
Show InChI InChI=1S/C19H17FN4OS/c20-13-4-1-11(2-5-13)12-3-6-14(21)15(9-12)23-18(25)19-24-16-10-22-8-7-17(16)26-19/h1-6,9,22H,7-8,10,21H2,(H,23,25)
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Rodin Therapeutics, Inc.

US Patent


Assay Description
HDAC2 containing a C-terminal HIS-Tag (Proteros) and fluorescently-labeled anti-HIS-antibody are diluted in one vial in assay buffer 50 mM Tris, pH 8...


US Patent US10421756 (2019)


BindingDB Entry DOI: 10.7270/Q2PK0JGK
More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))
BDBM413916
PNG
(US10421756, Compound 100)
Show SMILES Nc1ccc(cc1NC(=O)N1Cc2cncnc2C1)-c1ccncc1
Show InChI InChI=1S/C18H16N6O/c19-15-2-1-13(12-3-5-20-6-4-12)7-16(15)23-18(25)24-9-14-8-21-11-22-17(14)10-24/h1-8,11H,9-10,19H2,(H,23,25)
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Rodin Therapeutics, Inc.

US Patent


Assay Description
HDAC2 containing a C-terminal HIS-Tag (Proteros) and fluorescently-labeled anti-HIS-antibody are diluted in one vial in assay buffer 50 mM Tris, pH 8...


US Patent US10421756 (2019)


BindingDB Entry DOI: 10.7270/Q2PK0JGK
More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))
BDBM413917
PNG
(US10421756, Compound 101)
Show SMILES Nc1ccc(cc1NC(=O)N1Cc2nccnc2C1)-c1ccncc1
Show InChI InChI=1S/C18H16N6O/c19-14-2-1-13(12-3-5-20-6-4-12)9-15(14)23-18(25)24-10-16-17(11-24)22-8-7-21-16/h1-9H,10-11,19H2,(H,23,25)
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Rodin Therapeutics, Inc.

US Patent


Assay Description
HDAC2 containing a C-terminal HIS-Tag (Proteros) and fluorescently-labeled anti-HIS-antibody are diluted in one vial in assay buffer 50 mM Tris, pH 8...


US Patent US10421756 (2019)


BindingDB Entry DOI: 10.7270/Q2PK0JGK
More data for this
Ligand-Target Pair
Histone deacetylase 2


(Homo sapiens (Human))
BDBM413918
PNG
(US10421756, Compound 102)
Show SMILES Nc1ccc(cc1NC(=O)N1Cc2ccncc2C1)-c1ccncc1
Show InChI InChI=1S/C19H17N5O/c20-17-2-1-14(13-3-6-21-7-4-13)9-18(17)23-19(25)24-11-15-5-8-22-10-16(15)12-24/h1-10H,11-12,20H2,(H,23,25)
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Rodin Therapeutics, Inc.

US Patent


Assay Description
HDAC2 containing a C-terminal HIS-Tag (Proteros) and fluorescently-labeled anti-HIS-antibody are diluted in one vial in assay buffer 50 mM Tris, pH 8...


US Patent US10421756 (2019)


BindingDB Entry DOI: 10.7270/Q2PK0JGK
More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))
BDBM413924
PNG
(US10421756, Compound 108)
Show SMILES CC(=O)N1CC2CC1CN2C(=O)Nc1cc(ccc1N)-c1ccncc1
Show InChI InChI=1S/C19H21N5O2/c1-12(25)23-10-16-9-15(23)11-24(16)19(26)22-18-8-14(2-3-17(18)20)13-4-6-21-7-5-13/h2-8,15-16H,9-11,20H2,1H3,(H,22,26)
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Rodin Therapeutics, Inc.

US Patent


Assay Description
HDAC2 containing a C-terminal HIS-Tag (Proteros) and fluorescently-labeled anti-HIS-antibody are diluted in one vial in assay buffer 50 mM Tris, pH 8...


US Patent US10421756 (2019)


BindingDB Entry DOI: 10.7270/Q2PK0JGK
More data for this
Ligand-Target Pair
Histone deacetylase 2


(Homo sapiens (Human))
BDBM413928
PNG
(US10421756, Compound 112)
Show SMILES CC(C)(C)OC(=O)N1C2CCC1CN(C2)C(=O)Nc1cc(ccc1N)-c1ccc(F)cc1
Show InChI InChI=1S/C24H29FN4O3/c1-24(2,3)32-23(31)29-18-9-10-19(29)14-28(13-18)22(30)27-21-12-16(6-11-20(21)26)15-4-7-17(25)8-5-15/h4-8,11-12,18-19H,9-10,13-14,26H2,1-3H3,(H,27,30)
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Rodin Therapeutics, Inc.

US Patent


Assay Description
HDAC2 containing a C-terminal HIS-Tag (Proteros) and fluorescently-labeled anti-HIS-antibody are diluted in one vial in assay buffer 50 mM Tris, pH 8...


US Patent US10421756 (2019)


BindingDB Entry DOI: 10.7270/Q2PK0JGK
More data for this
Ligand-Target Pair
Histone deacetylase 2


(Homo sapiens (Human))
BDBM413930
PNG
(US10421756, Compound 114)
Show SMILES Nc1ccc(cc1NC(=O)N1CC2CNCC2C1)-c1ccc(F)cc1
Show InChI InChI=1S/C19H21FN4O/c20-16-4-1-12(2-5-16)13-3-6-17(21)18(7-13)23-19(25)24-10-14-8-22-9-15(14)11-24/h1-7,14-15,22H,8-11,21H2,(H,23,25)
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Rodin Therapeutics, Inc.

US Patent


Assay Description
HDAC2 containing a C-terminal HIS-Tag (Proteros) and fluorescently-labeled anti-HIS-antibody are diluted in one vial in assay buffer 50 mM Tris, pH 8...


US Patent US10421756 (2019)


BindingDB Entry DOI: 10.7270/Q2PK0JGK
More data for this
Ligand-Target Pair
Histone deacetylase 2


(Homo sapiens (Human))
BDBM413932
PNG
(US10421756, Compound 116)
Show SMILES CC(=O)N1C2CCC1CN(C2)C(=O)Nc1cc(ccc1N)-c1ccc(F)cc1
Show InChI InChI=1S/C21H23FN4O2/c1-13(27)26-17-7-8-18(26)12-25(11-17)21(28)24-20-10-15(4-9-19(20)23)14-2-5-16(22)6-3-14/h2-6,9-10,17-18H,7-8,11-12,23H2,1H3,(H,24,28)
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Rodin Therapeutics, Inc.

US Patent


Assay Description
HDAC2 containing a C-terminal HIS-Tag (Proteros) and fluorescently-labeled anti-HIS-antibody are diluted in one vial in assay buffer 50 mM Tris, pH 8...


US Patent US10421756 (2019)


BindingDB Entry DOI: 10.7270/Q2PK0JGK
More data for this
Ligand-Target Pair
Histone deacetylase 2


(Homo sapiens (Human))
BDBM413942
PNG
(US10421756, Compound 126)
Show SMILES Nc1ccc(cc1NC(=O)N1CC2CN(CC2C1)C1COC1)-c1ccc(F)cc1
Show InChI InChI=1S/C22H25FN4O2/c23-18-4-1-14(2-5-18)15-3-6-20(24)21(7-15)25-22(28)27-10-16-8-26(9-17(16)11-27)19-12-29-13-19/h1-7,16-17,19H,8-13,24H2,(H,25,28)
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Rodin Therapeutics, Inc.

US Patent


Assay Description
HDAC2 containing a C-terminal HIS-Tag (Proteros) and fluorescently-labeled anti-HIS-antibody are diluted in one vial in assay buffer 50 mM Tris, pH 8...


US Patent US10421756 (2019)


BindingDB Entry DOI: 10.7270/Q2PK0JGK
More data for this
Ligand-Target Pair
Histone deacetylase 2


(Homo sapiens (Human))
BDBM413944
PNG
(US10421756, Compound 128)
Show SMILES Nc1ccc(cc1NC(=O)c1cn2CC(CCc2n1)C#N)-c1ccc(F)cc1
Show InChI InChI=1S/C21H18FN5O/c22-16-5-2-14(3-6-16)15-4-7-17(24)18(9-15)26-21(28)19-12-27-11-13(10-23)1-8-20(27)25-19/h2-7,9,12-13H,1,8,11,24H2,(H,26,28)
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Rodin Therapeutics, Inc.

US Patent


Assay Description
HDAC2 containing a C-terminal HIS-Tag (Proteros) and fluorescently-labeled anti-HIS-antibody are diluted in one vial in assay buffer 50 mM Tris, pH 8...


US Patent US10421756 (2019)


BindingDB Entry DOI: 10.7270/Q2PK0JGK
More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))
BDBM413944
PNG
(US10421756, Compound 128)
Show SMILES Nc1ccc(cc1NC(=O)c1cn2CC(CCc2n1)C#N)-c1ccc(F)cc1
Show InChI InChI=1S/C21H18FN5O/c22-16-5-2-14(3-6-16)15-4-7-17(24)18(9-15)26-21(28)19-12-27-11-13(10-23)1-8-20(27)25-19/h2-7,9,12-13H,1,8,11,24H2,(H,26,28)
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Rodin Therapeutics, Inc.

US Patent


Assay Description
HDAC2 containing a C-terminal HIS-Tag (Proteros) and fluorescently-labeled anti-HIS-antibody are diluted in one vial in assay buffer 50 mM Tris, pH 8...


US Patent US10421756 (2019)


BindingDB Entry DOI: 10.7270/Q2PK0JGK
More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))
BDBM413951
PNG
(US10421756, Compound 135)
Show SMILES Nc1ccc(cc1NC(=O)N1Cc2ccncc2C1)-c1ccc(F)c(F)c1
Show InChI InChI=1S/C20H16F2N4O/c21-16-3-1-12(7-17(16)22)13-2-4-18(23)19(8-13)25-20(27)26-10-14-5-6-24-9-15(14)11-26/h1-9H,10-11,23H2,(H,25,27)
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Rodin Therapeutics, Inc.

US Patent


Assay Description
HDAC2 containing a C-terminal HIS-Tag (Proteros) and fluorescently-labeled anti-HIS-antibody are diluted in one vial in assay buffer 50 mM Tris, pH 8...


US Patent US10421756 (2019)


BindingDB Entry DOI: 10.7270/Q2PK0JGK
More data for this
Ligand-Target Pair
Histone deacetylase 2


(Homo sapiens (Human))
BDBM413953
PNG
(US10421756, Compound 137)
Show SMILES Nc1ccc(cc1NC(=O)N1Cc2nccnc2C1)-c1ccc(F)c(F)c1
Show InChI InChI=1S/C19H15F2N5O/c20-13-3-1-11(7-14(13)21)12-2-4-15(22)16(8-12)25-19(27)26-9-17-18(10-26)24-6-5-23-17/h1-8H,9-10,22H2,(H,25,27)
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Rodin Therapeutics, Inc.

US Patent


Assay Description
HDAC2 containing a C-terminal HIS-Tag (Proteros) and fluorescently-labeled anti-HIS-antibody are diluted in one vial in assay buffer 50 mM Tris, pH 8...


US Patent US10421756 (2019)


BindingDB Entry DOI: 10.7270/Q2PK0JGK
More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))
BDBM413953
PNG
(US10421756, Compound 137)
Show SMILES Nc1ccc(cc1NC(=O)N1Cc2nccnc2C1)-c1ccc(F)c(F)c1
Show InChI InChI=1S/C19H15F2N5O/c20-13-3-1-11(7-14(13)21)12-2-4-15(22)16(8-12)25-19(27)26-9-17-18(10-26)24-6-5-23-17/h1-8H,9-10,22H2,(H,25,27)
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Rodin Therapeutics, Inc.

US Patent


Assay Description
HDAC2 containing a C-terminal HIS-Tag (Proteros) and fluorescently-labeled anti-HIS-antibody are diluted in one vial in assay buffer 50 mM Tris, pH 8...


US Patent US10421756 (2019)


BindingDB Entry DOI: 10.7270/Q2PK0JGK
More data for this
Ligand-Target Pair
Histone deacetylase 2


(Homo sapiens (Human))
BDBM413954
PNG
(US10421756, Compound 138)
Show SMILES COCCN1CCC2(C1)CCN(CC2)C(=O)Nc1cc(ccc1N)-c1ccc(F)cc1
Show InChI InChI=1S/C24H31FN4O2/c1-31-15-14-28-11-8-24(17-28)9-12-29(13-10-24)23(30)27-22-16-19(4-7-21(22)26)18-2-5-20(25)6-3-18/h2-7,16H,8-15,17,26H2,1H3,(H,27,30)
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Rodin Therapeutics, Inc.

US Patent


Assay Description
HDAC2 containing a C-terminal HIS-Tag (Proteros) and fluorescently-labeled anti-HIS-antibody are diluted in one vial in assay buffer 50 mM Tris, pH 8...


US Patent US10421756 (2019)


BindingDB Entry DOI: 10.7270/Q2PK0JGK
More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))
BDBM413956
PNG
(US10421756, Compound 140)
Show SMILES Nc1ccc(cc1NC(=O)N1Cc2ccncc2C1)-c1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C21H17F3N4O/c22-21(23,24)17-4-1-13(2-5-17)14-3-6-18(25)19(9-14)27-20(29)28-11-15-7-8-26-10-16(15)12-28/h1-10H,11-12,25H2,(H,27,29)
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Rodin Therapeutics, Inc.

US Patent


Assay Description
HDAC2 containing a C-terminal HIS-Tag (Proteros) and fluorescently-labeled anti-HIS-antibody are diluted in one vial in assay buffer 50 mM Tris, pH 8...


US Patent US10421756 (2019)


BindingDB Entry DOI: 10.7270/Q2PK0JGK
More data for this
Ligand-Target Pair
Histone deacetylase 2


(Homo sapiens (Human))
BDBM413969
PNG
(US10421756, Compound 153)
Show SMILES Nc1ccc(cc1NC(=O)N1CC2(C1)CCCCO2)-c1ccc(F)cc1
Show InChI InChI=1S/C20H22FN3O2/c21-16-6-3-14(4-7-16)15-5-8-17(22)18(11-15)23-19(25)24-12-20(13-24)9-1-2-10-26-20/h3-8,11H,1-2,9-10,12-13,22H2,(H,23,25)
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Rodin Therapeutics, Inc.

US Patent


Assay Description
HDAC2 containing a C-terminal HIS-Tag (Proteros) and fluorescently-labeled anti-HIS-antibody are diluted in one vial in assay buffer 50 mM Tris, pH 8...


US Patent US10421756 (2019)


BindingDB Entry DOI: 10.7270/Q2PK0JGK
More data for this
Ligand-Target Pair
Histone deacetylase 2


(Homo sapiens (Human))
BDBM413978
PNG
(US10421756, Compound 162)
Show SMILES Nc1ccc(cc1NC(=O)N1Cc2ccncc2C1)-c1ccc(OC(F)F)cc1
Show InChI InChI=1S/C21H18F2N4O2/c22-20(23)29-17-4-1-13(2-5-17)14-3-6-18(24)19(9-14)26-21(28)27-11-15-7-8-25-10-16(15)12-27/h1-10,20H,11-12,24H2,(H,26,28)
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Rodin Therapeutics, Inc.

US Patent


Assay Description
HDAC2 containing a C-terminal HIS-Tag (Proteros) and fluorescently-labeled anti-HIS-antibody are diluted in one vial in assay buffer 50 mM Tris, pH 8...


US Patent US10421756 (2019)


BindingDB Entry DOI: 10.7270/Q2PK0JGK
More data for this
Ligand-Target Pair
Histone deacetylase 2


(Homo sapiens (Human))
BDBM413979
PNG
(US10421756, Compound 163)
Show SMILES Nc1ccc(cc1NC(=O)N1Cc2ccncc2C1)-c1ccc(F)c(Cl)c1
Show InChI InChI=1S/C20H16ClFN4O/c21-16-7-12(1-3-17(16)22)13-2-4-18(23)19(8-13)25-20(27)26-10-14-5-6-24-9-15(14)11-26/h1-9H,10-11,23H2,(H,25,27)
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Rodin Therapeutics, Inc.

US Patent


Assay Description
HDAC2 containing a C-terminal HIS-Tag (Proteros) and fluorescently-labeled anti-HIS-antibody are diluted in one vial in assay buffer 50 mM Tris, pH 8...


US Patent US10421756 (2019)


BindingDB Entry DOI: 10.7270/Q2PK0JGK
More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))
BDBM413979
PNG
(US10421756, Compound 163)
Show SMILES Nc1ccc(cc1NC(=O)N1Cc2ccncc2C1)-c1ccc(F)c(Cl)c1
Show InChI InChI=1S/C20H16ClFN4O/c21-16-7-12(1-3-17(16)22)13-2-4-18(23)19(8-13)25-20(27)26-10-14-5-6-24-9-15(14)11-26/h1-9H,10-11,23H2,(H,25,27)
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Rodin Therapeutics, Inc.

US Patent


Assay Description
HDAC2 containing a C-terminal HIS-Tag (Proteros) and fluorescently-labeled anti-HIS-antibody are diluted in one vial in assay buffer 50 mM Tris, pH 8...


US Patent US10421756 (2019)


BindingDB Entry DOI: 10.7270/Q2PK0JGK
More data for this
Ligand-Target Pair
Histone deacetylase 2


(Homo sapiens (Human))
BDBM413921
PNG
(US10421756, Compound 105)
Show SMILES Nc1ccc(cc1NC(=O)N1CC2CCC(C1)O2)-c1ccncc1
Show InChI InChI=1S/C18H20N4O2/c19-16-4-1-13(12-5-7-20-8-6-12)9-17(16)21-18(23)22-10-14-2-3-15(11-22)24-14/h1,4-9,14-15H,2-3,10-11,19H2,(H,21,23)
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Rodin Therapeutics, Inc.

US Patent


Assay Description
HDAC2 containing a C-terminal HIS-Tag (Proteros) and fluorescently-labeled anti-HIS-antibody are diluted in one vial in assay buffer 50 mM Tris, pH 8...


US Patent US10421756 (2019)


BindingDB Entry DOI: 10.7270/Q2PK0JGK
More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))
BDBM413922
PNG
(US10421756, Compound 106 | US10421756, Compound 11...)
Show SMILES CC(C)(C)OC(=O)N1C2CCC1CN(C2)C(=O)Nc1cc(ccc1N)-c1ccncc1
Show InChI InChI=1S/C23H29N5O3/c1-23(2,3)31-22(30)28-17-5-6-18(28)14-27(13-17)21(29)26-20-12-16(4-7-19(20)24)15-8-10-25-11-9-15/h4,7-12,17-18H,5-6,13-14,24H2,1-3H3,(H,26,29)
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Rodin Therapeutics, Inc.

US Patent


Assay Description
HDAC2 containing a C-terminal HIS-Tag (Proteros) and fluorescently-labeled anti-HIS-antibody are diluted in one vial in assay buffer 50 mM Tris, pH 8...


US Patent US10421756 (2019)


BindingDB Entry DOI: 10.7270/Q2PK0JGK
More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))
BDBM413922
PNG
(US10421756, Compound 106 | US10421756, Compound 11...)
Show SMILES CC(C)(C)OC(=O)N1C2CCC1CN(C2)C(=O)Nc1cc(ccc1N)-c1ccncc1
Show InChI InChI=1S/C23H29N5O3/c1-23(2,3)31-22(30)28-17-5-6-18(28)14-27(13-17)21(29)26-20-12-16(4-7-19(20)24)15-8-10-25-11-9-15/h4,7-12,17-18H,5-6,13-14,24H2,1-3H3,(H,26,29)
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Rodin Therapeutics, Inc.

US Patent


Assay Description
HDAC2 containing a C-terminal HIS-Tag (Proteros) and fluorescently-labeled anti-HIS-antibody are diluted in one vial in assay buffer 50 mM Tris, pH 8...


US Patent US10421756 (2019)


BindingDB Entry DOI: 10.7270/Q2PK0JGK
More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))
BDBM413935
PNG
(US10421756, Compound 119)
Show SMILES Nc1ccc(cc1NC(=O)N1Cc2nccnc2C1)-c1ccc(F)cc1
Show InChI InChI=1S/C19H16FN5O/c20-14-4-1-12(2-5-14)13-3-6-15(21)16(9-13)24-19(26)25-10-17-18(11-25)23-8-7-22-17/h1-9H,10-11,21H2,(H,24,26)
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Rodin Therapeutics, Inc.

US Patent


Assay Description
HDAC2 containing a C-terminal HIS-Tag (Proteros) and fluorescently-labeled anti-HIS-antibody are diluted in one vial in assay buffer 50 mM Tris, pH 8...


US Patent US10421756 (2019)


BindingDB Entry DOI: 10.7270/Q2PK0JGK
More data for this
Ligand-Target Pair
Histone deacetylase 2


(Homo sapiens (Human))
BDBM413941
PNG
(US10421756, Compound 125)
Show SMILES Nc1ccc(cc1NC(=O)N1CC2CN(CC2C1)C(=O)C1CC1)-c1ccc(F)cc1
Show InChI InChI=1S/C23H25FN4O2/c24-19-6-3-14(4-7-19)16-5-8-20(25)21(9-16)26-23(30)28-12-17-10-27(11-18(17)13-28)22(29)15-1-2-15/h3-9,15,17-18H,1-2,10-13,25H2,(H,26,30)
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n/an/an/a 300n/an/an/an/an/a



Rodin Therapeutics, Inc.

US Patent


Assay Description
HDAC2 containing a C-terminal HIS-Tag (Proteros) and fluorescently-labeled anti-HIS-antibody are diluted in one vial in assay buffer 50 mM Tris, pH 8...


US Patent US10421756 (2019)


BindingDB Entry DOI: 10.7270/Q2PK0JGK
More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))
BDBM413943
PNG
(US10421756, Compound 127)
Show SMILES Nc1ccc(cc1NC(=O)N1CCC2(COC2)CC1)-c1ccc(F)cc1
Show InChI InChI=1S/C20H22FN3O2/c21-16-4-1-14(2-5-16)15-3-6-17(22)18(11-15)23-19(25)24-9-7-20(8-10-24)12-26-13-20/h1-6,11H,7-10,12-13,22H2,(H,23,25)
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n/an/an/a<100n/an/an/an/an/a



Rodin Therapeutics, Inc.

US Patent


Assay Description
HDAC2 containing a C-terminal HIS-Tag (Proteros) and fluorescently-labeled anti-HIS-antibody are diluted in one vial in assay buffer 50 mM Tris, pH 8...


US Patent US10421756 (2019)


BindingDB Entry DOI: 10.7270/Q2PK0JGK
More data for this
Ligand-Target Pair
Histone deacetylase 2


(Homo sapiens (Human))
BDBM413945
PNG
(US10421756, Compound 129)
Show SMILES Nc1ccc(cc1NC(=O)N1CC2CN(CC2C1)C1COC1)-c1ccncc1
Show InChI InChI=1S/C21H25N5O2/c22-19-2-1-15(14-3-5-23-6-4-14)7-20(19)24-21(27)26-10-16-8-25(9-17(16)11-26)18-12-28-13-18/h1-7,16-18H,8-13,22H2,(H,24,27)
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Rodin Therapeutics, Inc.

US Patent


Assay Description
HDAC2 containing a C-terminal HIS-Tag (Proteros) and fluorescently-labeled anti-HIS-antibody are diluted in one vial in assay buffer 50 mM Tris, pH 8...


US Patent US10421756 (2019)


BindingDB Entry DOI: 10.7270/Q2PK0JGK
More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))
BDBM413945
PNG
(US10421756, Compound 129)
Show SMILES Nc1ccc(cc1NC(=O)N1CC2CN(CC2C1)C1COC1)-c1ccncc1
Show InChI InChI=1S/C21H25N5O2/c22-19-2-1-15(14-3-5-23-6-4-14)7-20(19)24-21(27)26-10-16-8-25(9-17(16)11-26)18-12-28-13-18/h1-7,16-18H,8-13,22H2,(H,24,27)
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Rodin Therapeutics, Inc.

US Patent


Assay Description
HDAC2 containing a C-terminal HIS-Tag (Proteros) and fluorescently-labeled anti-HIS-antibody are diluted in one vial in assay buffer 50 mM Tris, pH 8...


US Patent US10421756 (2019)


BindingDB Entry DOI: 10.7270/Q2PK0JGK
More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))
BDBM413947
PNG
(US10421756, Compound 131)
Show SMILES Nc1ccc(cc1NC(=O)c1cn2CCNCc2n1)-c1ccc(F)c(F)c1
Show InChI InChI=1S/C19H17F2N5O/c20-13-3-1-11(7-14(13)21)12-2-4-15(22)16(8-12)25-19(27)17-10-26-6-5-23-9-18(26)24-17/h1-4,7-8,10,23H,5-6,9,22H2,(H,25,27)
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Rodin Therapeutics, Inc.

US Patent


Assay Description
HDAC2 containing a C-terminal HIS-Tag (Proteros) and fluorescently-labeled anti-HIS-antibody are diluted in one vial in assay buffer 50 mM Tris, pH 8...


US Patent US10421756 (2019)


BindingDB Entry DOI: 10.7270/Q2PK0JGK
More data for this
Ligand-Target Pair
Histone deacetylase 2


(Homo sapiens (Human))
BDBM413952
PNG
(US10421756, Compound 136)
Show SMILES COCCN1CCC2(C1)CCN(CC2)C(=O)Nc1cc(ccc1N)-c1ccncc1
Show InChI InChI=1S/C23H31N5O2/c1-30-15-14-27-11-6-23(17-27)7-12-28(13-8-23)22(29)26-21-16-19(2-3-20(21)24)18-4-9-25-10-5-18/h2-5,9-10,16H,6-8,11-15,17,24H2,1H3,(H,26,29)
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Rodin Therapeutics, Inc.

US Patent


Assay Description
HDAC2 containing a C-terminal HIS-Tag (Proteros) and fluorescently-labeled anti-HIS-antibody are diluted in one vial in assay buffer 50 mM Tris, pH 8...


US Patent US10421756 (2019)


BindingDB Entry DOI: 10.7270/Q2PK0JGK
More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))
BDBM413955
PNG
(US10421756, Compound 139)
Show SMILES COc1ccc(cc1)-c1ccc(N)c(NC(=O)N2Cc3ccncc3C2)c1
Show InChI InChI=1S/C21H20N4O2/c1-27-18-5-2-14(3-6-18)15-4-7-19(22)20(10-15)24-21(26)25-12-16-8-9-23-11-17(16)13-25/h2-11H,12-13,22H2,1H3,(H,24,26)
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Rodin Therapeutics, Inc.

US Patent


Assay Description
HDAC2 containing a C-terminal HIS-Tag (Proteros) and fluorescently-labeled anti-HIS-antibody are diluted in one vial in assay buffer 50 mM Tris, pH 8...


US Patent US10421756 (2019)


BindingDB Entry DOI: 10.7270/Q2PK0JGK
More data for this
Ligand-Target Pair
Histone deacetylase 2


(Homo sapiens (Human))
BDBM413963
PNG
(US10421756, Compound 147)
Show SMILES Nc1ccc(cc1NC(=O)c1nc2CCNCc2s1)-c1ccc(F)cc1
Show InChI InChI=1S/C19H17FN4OS/c20-13-4-1-11(2-5-13)12-3-6-14(21)16(9-12)23-18(25)19-24-15-7-8-22-10-17(15)26-19/h1-6,9,22H,7-8,10,21H2,(H,23,25)
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Rodin Therapeutics, Inc.

US Patent


Assay Description
HDAC2 containing a C-terminal HIS-Tag (Proteros) and fluorescently-labeled anti-HIS-antibody are diluted in one vial in assay buffer 50 mM Tris, pH 8...


US Patent US10421756 (2019)


BindingDB Entry DOI: 10.7270/Q2PK0JGK
More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))
BDBM413964
PNG
(US10421756, Compound 148)
Show SMILES Nc1ccc(cc1NC(=O)N1CC2(C1)CCOCC2)-c1ccc(F)cc1
Show InChI InChI=1S/C20H22FN3O2/c21-16-4-1-14(2-5-16)15-3-6-17(22)18(11-15)23-19(25)24-12-20(13-24)7-9-26-10-8-20/h1-6,11H,7-10,12-13,22H2,(H,23,25)
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n/an/an/a 2.75E+3n/an/an/an/an/a



Rodin Therapeutics, Inc.

US Patent


Assay Description
HDAC2 containing a C-terminal HIS-Tag (Proteros) and fluorescently-labeled anti-HIS-antibody are diluted in one vial in assay buffer 50 mM Tris, pH 8...


US Patent US10421756 (2019)


BindingDB Entry DOI: 10.7270/Q2PK0JGK
More data for this
Ligand-Target Pair
Histone deacetylase 2


(Homo sapiens (Human))
BDBM413973
PNG
(US10421756, Compound 157)
Show SMILES CC(C)COC(=O)N1CC2CN(CC2C1)C(=O)Nc1cc(ccc1N)-c1ccc(F)cc1
Show InChI InChI=1S/C24H29FN4O3/c1-15(2)14-32-24(31)29-12-18-10-28(11-19(18)13-29)23(30)27-22-9-17(5-8-21(22)26)16-3-6-20(25)7-4-16/h3-9,15,18-19H,10-14,26H2,1-2H3,(H,27,30)
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Rodin Therapeutics, Inc.

US Patent


Assay Description
HDAC2 containing a C-terminal HIS-Tag (Proteros) and fluorescently-labeled anti-HIS-antibody are diluted in one vial in assay buffer 50 mM Tris, pH 8...


US Patent US10421756 (2019)


BindingDB Entry DOI: 10.7270/Q2PK0JGK
More data for this
Ligand-Target Pair
Histone deacetylase 2


(Homo sapiens (Human))
BDBM413975
PNG
(US10421756, Compound 159)
Show SMILES Nc1ccc(cc1NC(=O)N1CC2CN(CC2C1)C(=O)OC1CCC1)-c1ccc(F)cc1
Show InChI InChI=1S/C24H27FN4O3/c25-19-7-4-15(5-8-19)16-6-9-21(26)22(10-16)27-23(30)28-11-17-13-29(14-18(17)12-28)24(31)32-20-2-1-3-20/h4-10,17-18,20H,1-3,11-14,26H2,(H,27,30)
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Rodin Therapeutics, Inc.

US Patent


Assay Description
HDAC2 containing a C-terminal HIS-Tag (Proteros) and fluorescently-labeled anti-HIS-antibody are diluted in one vial in assay buffer 50 mM Tris, pH 8...


US Patent US10421756 (2019)


BindingDB Entry DOI: 10.7270/Q2PK0JGK
More data for this
Ligand-Target Pair
Histone deacetylase 2


(Homo sapiens (Human))
BDBM413977
PNG
(US10421756, Compound 161)
Show SMILES CC(C)(C)OC(=O)N1CCC2(C1)CCN(CC2)C(=O)Nc1cc(ccc1N)-c1ccc(F)cc1
Show InChI InChI=1S/C26H33FN4O3/c1-25(2,3)34-24(33)31-15-12-26(17-31)10-13-30(14-11-26)23(32)29-22-16-19(6-9-21(22)28)18-4-7-20(27)8-5-18/h4-9,16H,10-15,17,28H2,1-3H3,(H,29,32)
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Rodin Therapeutics, Inc.

US Patent


Assay Description
HDAC2 containing a C-terminal HIS-Tag (Proteros) and fluorescently-labeled anti-HIS-antibody are diluted in one vial in assay buffer 50 mM Tris, pH 8...


US Patent US10421756 (2019)


BindingDB Entry DOI: 10.7270/Q2PK0JGK
More data for this
Ligand-Target Pair
Histone deacetylase 2


(Homo sapiens (Human))
BDBM413986
PNG
(US10421756, Compound 170)
Show SMILES Nc1ccc(cc1NC(=O)N1CC2CCNCC2C1)-c1ccc(F)cc1
Show InChI InChI=1S/C20H23FN4O/c21-17-4-1-13(2-5-17)14-3-6-18(22)19(9-14)24-20(26)25-11-15-7-8-23-10-16(15)12-25/h1-6,9,15-16,23H,7-8,10-12,22H2,(H,24,26)
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n/an/an/a 2.75E+3n/an/an/an/an/a



Rodin Therapeutics, Inc.

US Patent


Assay Description
HDAC2 containing a C-terminal HIS-Tag (Proteros) and fluorescently-labeled anti-HIS-antibody are diluted in one vial in assay buffer 50 mM Tris, pH 8...


US Patent US10421756 (2019)


BindingDB Entry DOI: 10.7270/Q2PK0JGK
More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))
BDBM413986
PNG
(US10421756, Compound 170)
Show SMILES Nc1ccc(cc1NC(=O)N1CC2CCNCC2C1)-c1ccc(F)cc1
Show InChI InChI=1S/C20H23FN4O/c21-17-4-1-13(2-5-17)14-3-6-18(22)19(9-14)24-20(26)25-11-15-7-8-23-10-16(15)12-25/h1-6,9,15-16,23H,7-8,10-12,22H2,(H,24,26)
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Rodin Therapeutics, Inc.

US Patent


Assay Description
HDAC2 containing a C-terminal HIS-Tag (Proteros) and fluorescently-labeled anti-HIS-antibody are diluted in one vial in assay buffer 50 mM Tris, pH 8...


US Patent US10421756 (2019)


BindingDB Entry DOI: 10.7270/Q2PK0JGK
More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))
BDBM413990
PNG
(US10421756, Compound 174)
Show SMILES Nc1ccc(cc1NC(=O)c1nc2CNCCc2s1)-c1ccncc1
Show InChI InChI=1S/C18H17N5OS/c19-13-2-1-12(11-3-6-20-7-4-11)9-14(13)22-17(24)18-23-15-10-21-8-5-16(15)25-18/h1-4,6-7,9,21H,5,8,10,19H2,(H,22,24)
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Rodin Therapeutics, Inc.

US Patent


Assay Description
HDAC2 containing a C-terminal HIS-Tag (Proteros) and fluorescently-labeled anti-HIS-antibody are diluted in one vial in assay buffer 50 mM Tris, pH 8...


US Patent US10421756 (2019)


BindingDB Entry DOI: 10.7270/Q2PK0JGK
More data for this
Ligand-Target Pair
Histone deacetylase 2


(Homo sapiens (Human))
BDBM413922
PNG
(US10421756, Compound 106 | US10421756, Compound 11...)
Show SMILES CC(C)(C)OC(=O)N1C2CCC1CN(C2)C(=O)Nc1cc(ccc1N)-c1ccncc1
Show InChI InChI=1S/C23H29N5O3/c1-23(2,3)31-22(30)28-17-5-6-18(28)14-27(13-17)21(29)26-20-12-16(4-7-19(20)24)15-8-10-25-11-9-15/h4,7-12,17-18H,5-6,13-14,24H2,1-3H3,(H,26,29)
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Rodin Therapeutics, Inc.

US Patent


Assay Description
HDAC2 containing a C-terminal HIS-Tag (Proteros) and fluorescently-labeled anti-HIS-antibody are diluted in one vial in assay buffer 50 mM Tris, pH 8...


US Patent US10421756 (2019)


BindingDB Entry DOI: 10.7270/Q2PK0JGK
More data for this
Ligand-Target Pair
Histone deacetylase 2


(Homo sapiens (Human))
BDBM413929
PNG
(US10421756, Compound 113)
Show SMILES Nc1ccc(cc1NC(=O)N1CC2CCC(C1)N2)-c1ccc(F)cc1
Show InChI InChI=1S/C19H21FN4O/c20-14-4-1-12(2-5-14)13-3-8-17(21)18(9-13)23-19(25)24-10-15-6-7-16(11-24)22-15/h1-5,8-9,15-16,22H,6-7,10-11,21H2,(H,23,25)
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Rodin Therapeutics, Inc.

US Patent


Assay Description
HDAC2 containing a C-terminal HIS-Tag (Proteros) and fluorescently-labeled anti-HIS-antibody are diluted in one vial in assay buffer 50 mM Tris, pH 8...


US Patent US10421756 (2019)


BindingDB Entry DOI: 10.7270/Q2PK0JGK
More data for this
Ligand-Target Pair
Histone deacetylase 2


(Homo sapiens (Human))
BDBM413938
PNG
(US10421756, Compound 122)
Show SMILES Nc1ccc(cc1NC(=O)c1cn2CCNCc2n1)-c1ccc(F)cc1
Show InChI InChI=1S/C19H18FN5O/c20-14-4-1-12(2-5-14)13-3-6-15(21)16(9-13)24-19(26)17-11-25-8-7-22-10-18(25)23-17/h1-6,9,11,22H,7-8,10,21H2,(H,24,26)
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Rodin Therapeutics, Inc.

US Patent


Assay Description
HDAC2 containing a C-terminal HIS-Tag (Proteros) and fluorescently-labeled anti-HIS-antibody are diluted in one vial in assay buffer 50 mM Tris, pH 8...


US Patent US10421756 (2019)


BindingDB Entry DOI: 10.7270/Q2PK0JGK
More data for this
Ligand-Target Pair
Histone deacetylase 2


(Homo sapiens (Human))
BDBM413940
PNG
(US10421756, Compound 124)
Show SMILES CC(C)(C)OC(=O)N1CC2CN(CC2C1)C(=O)Nc1cc(ccc1N)-c1ccc(F)cc1
Show InChI InChI=1S/C24H29FN4O3/c1-24(2,3)32-23(31)29-13-17-11-28(12-18(17)14-29)22(30)27-21-10-16(6-9-20(21)26)15-4-7-19(25)8-5-15/h4-10,17-18H,11-14,26H2,1-3H3,(H,27,30)
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Rodin Therapeutics, Inc.

US Patent


Assay Description
HDAC2 containing a C-terminal HIS-Tag (Proteros) and fluorescently-labeled anti-HIS-antibody are diluted in one vial in assay buffer 50 mM Tris, pH 8...


US Patent US10421756 (2019)


BindingDB Entry DOI: 10.7270/Q2PK0JGK
More data for this
Ligand-Target Pair
Histone deacetylase 2


(Homo sapiens (Human))
BDBM413947
PNG
(US10421756, Compound 131)
Show SMILES Nc1ccc(cc1NC(=O)c1cn2CCNCc2n1)-c1ccc(F)c(F)c1
Show InChI InChI=1S/C19H17F2N5O/c20-13-3-1-11(7-14(13)21)12-2-4-15(22)16(8-12)25-19(27)17-10-26-6-5-23-9-18(26)24-17/h1-4,7-8,10,23H,5-6,9,22H2,(H,25,27)
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Rodin Therapeutics, Inc.

US Patent


Assay Description
HDAC2 containing a C-terminal HIS-Tag (Proteros) and fluorescently-labeled anti-HIS-antibody are diluted in one vial in assay buffer 50 mM Tris, pH 8...


US Patent US10421756 (2019)


BindingDB Entry DOI: 10.7270/Q2PK0JGK
More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))
BDBM413948
PNG
(US10421756, Compound 132)
Show SMILES Nc1ccc(cc1NC(=O)N1Cc2ccncc2C1)-c1ccc(cc1F)C(F)(F)F
Show InChI InChI=1S/C21H16F4N4O/c22-17-8-15(21(23,24)25)2-3-16(17)12-1-4-18(26)19(7-12)28-20(30)29-10-13-5-6-27-9-14(13)11-29/h1-9H,10-11,26H2,(H,28,30)
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n/an/an/a 2.75E+3n/an/an/an/an/a



Rodin Therapeutics, Inc.

US Patent


Assay Description
HDAC2 containing a C-terminal HIS-Tag (Proteros) and fluorescently-labeled anti-HIS-antibody are diluted in one vial in assay buffer 50 mM Tris, pH 8...


US Patent US10421756 (2019)


BindingDB Entry DOI: 10.7270/Q2PK0JGK
More data for this
Ligand-Target Pair
Histone deacetylase 2


(Homo sapiens (Human))
BDBM413949
PNG
(US10421756, Compound 133)
Show SMILES Nc1ccc(cc1NC(=O)N1Cc2ccncc2C1)-c1ccc(F)cc1F
Show InChI InChI=1S/C20H16F2N4O/c21-15-2-3-16(17(22)8-15)12-1-4-18(23)19(7-12)25-20(27)26-10-13-5-6-24-9-14(13)11-26/h1-9H,10-11,23H2,(H,25,27)
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n/an/an/a 300n/an/an/an/an/a



Rodin Therapeutics, Inc.

US Patent


Assay Description
HDAC2 containing a C-terminal HIS-Tag (Proteros) and fluorescently-labeled anti-HIS-antibody are diluted in one vial in assay buffer 50 mM Tris, pH 8...


US Patent US10421756 (2019)


BindingDB Entry DOI: 10.7270/Q2PK0JGK
More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))
BDBM413949
PNG
(US10421756, Compound 133)
Show SMILES Nc1ccc(cc1NC(=O)N1Cc2ccncc2C1)-c1ccc(F)cc1F
Show InChI InChI=1S/C20H16F2N4O/c21-15-2-3-16(17(22)8-15)12-1-4-18(23)19(7-12)25-20(27)26-10-13-5-6-24-9-14(13)11-26/h1-9H,10-11,23H2,(H,25,27)
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n/an/an/a<100n/an/an/an/an/a



Rodin Therapeutics, Inc.

US Patent


Assay Description
HDAC2 containing a C-terminal HIS-Tag (Proteros) and fluorescently-labeled anti-HIS-antibody are diluted in one vial in assay buffer 50 mM Tris, pH 8...


US Patent US10421756 (2019)


BindingDB Entry DOI: 10.7270/Q2PK0JGK
More data for this
Ligand-Target Pair
Histone deacetylase 2


(Homo sapiens (Human))
BDBM413957
PNG
(US10421756, Compound 141)
Show SMILES Cc1cc(F)ccc1-c1ccc(N)c(NC(=O)N2Cc3ccncc3C2)c1
Show InChI InChI=1S/C21H19FN4O/c1-13-8-17(22)3-4-18(13)14-2-5-19(23)20(9-14)25-21(27)26-11-15-6-7-24-10-16(15)12-26/h2-10H,11-12,23H2,1H3,(H,25,27)
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n/an/an/a>5.00E+3n/an/an/an/an/a



Rodin Therapeutics, Inc.

US Patent


Assay Description
HDAC2 containing a C-terminal HIS-Tag (Proteros) and fluorescently-labeled anti-HIS-antibody are diluted in one vial in assay buffer 50 mM Tris, pH 8...


US Patent US10421756 (2019)


BindingDB Entry DOI: 10.7270/Q2PK0JGK
More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))
BDBM413974
PNG
(US10421756, Compound 158)
Show SMILES Nc1ccc(cc1NC(=O)N1CC2CN(CC2C1)C(=O)OC1CC1)-c1ccc(F)cc1
Show InChI InChI=1S/C23H25FN4O3/c24-18-4-1-14(2-5-18)15-3-8-20(25)21(9-15)26-22(29)27-10-16-12-28(13-17(16)11-27)23(30)31-19-6-7-19/h1-5,8-9,16-17,19H,6-7,10-13,25H2,(H,26,29)
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n/an/an/a<100n/an/an/an/an/a



Rodin Therapeutics, Inc.

US Patent


Assay Description
HDAC2 containing a C-terminal HIS-Tag (Proteros) and fluorescently-labeled anti-HIS-antibody are diluted in one vial in assay buffer 50 mM Tris, pH 8...


US Patent US10421756 (2019)


BindingDB Entry DOI: 10.7270/Q2PK0JGK
More data for this
Ligand-Target Pair
Histone deacetylase 2


(Homo sapiens (Human))
BDBM413976
PNG
(US10421756, Compound 160)
Show SMILES CC(C)CC(=O)N1CC2CN(CC2C1)C(=O)Nc1cc(ccc1N)-c1ccc(F)cc1
Show InChI InChI=1S/C24H29FN4O2/c1-15(2)9-23(30)28-11-18-13-29(14-19(18)12-28)24(31)27-22-10-17(5-8-21(22)26)16-3-6-20(25)7-4-16/h3-8,10,15,18-19H,9,11-14,26H2,1-2H3,(H,27,31)
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n/an/an/a 300n/an/an/an/an/a



Rodin Therapeutics, Inc.

US Patent


Assay Description
HDAC2 containing a C-terminal HIS-Tag (Proteros) and fluorescently-labeled anti-HIS-antibody are diluted in one vial in assay buffer 50 mM Tris, pH 8...


US Patent US10421756 (2019)


BindingDB Entry DOI: 10.7270/Q2PK0JGK
More data for this
Ligand-Target Pair
Histone deacetylase 2


(Homo sapiens (Human))
BDBM413982
PNG
(US10421756, Compound 166)
Show SMILES CC(C)(C)OC(=O)N1CCC2(CN(C2)C(=O)Nc2cc(ccc2N)-c2ccc(F)cc2)CC1
Show InChI InChI=1S/C25H31FN4O3/c1-24(2,3)33-23(32)29-12-10-25(11-13-29)15-30(16-25)22(31)28-21-14-18(6-9-20(21)27)17-4-7-19(26)8-5-17/h4-9,14H,10-13,15-16,27H2,1-3H3,(H,28,31)
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n/an/an/a 2.75E+3n/an/an/an/an/a



Rodin Therapeutics, Inc.

US Patent


Assay Description
HDAC2 containing a C-terminal HIS-Tag (Proteros) and fluorescently-labeled anti-HIS-antibody are diluted in one vial in assay buffer 50 mM Tris, pH 8...


US Patent US10421756 (2019)


BindingDB Entry DOI: 10.7270/Q2PK0JGK
More data for this
Ligand-Target Pair
Histone deacetylase 2


(Homo sapiens (Human))
BDBM413983
PNG
(US10421756, Compound 167)
Show SMILES Nc1ccc(cc1NC(=O)N1Cc2ccncc2C1)-c1ccc(cn1)C(F)(F)F
Show InChI InChI=1S/C20H16F3N5O/c21-20(22,23)15-2-4-17(26-9-15)12-1-3-16(24)18(7-12)27-19(29)28-10-13-5-6-25-8-14(13)11-28/h1-9H,10-11,24H2,(H,27,29)
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n/an/an/a 2.75E+3n/an/an/an/an/a



Rodin Therapeutics, Inc.

US Patent


Assay Description
HDAC2 containing a C-terminal HIS-Tag (Proteros) and fluorescently-labeled anti-HIS-antibody are diluted in one vial in assay buffer 50 mM Tris, pH 8...


US Patent US10421756 (2019)


BindingDB Entry DOI: 10.7270/Q2PK0JGK
More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))
BDBM413984
PNG
(US10421756, Compound 168)
Show SMILES Nc1ccc(cc1NC(=O)N1Cc2ccncc2C1)-c1ccco1
Show InChI InChI=1S/C18H16N4O2/c19-15-4-3-12(17-2-1-7-24-17)8-16(15)21-18(23)22-10-13-5-6-20-9-14(13)11-22/h1-9H,10-11,19H2,(H,21,23)
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n/an/an/a<100n/an/an/an/an/a



Rodin Therapeutics, Inc.

US Patent


Assay Description
HDAC2 containing a C-terminal HIS-Tag (Proteros) and fluorescently-labeled anti-HIS-antibody are diluted in one vial in assay buffer 50 mM Tris, pH 8...


US Patent US10421756 (2019)


BindingDB Entry DOI: 10.7270/Q2PK0JGK
More data for this
Ligand-Target Pair
Histone deacetylase 2


(Homo sapiens (Human))
BDBM413985
PNG
(US10421756, Compound 169)
Show SMILES Nc1ccc(cc1NC(=O)N1CC2(C1)CCNCC2)-c1ccc(F)cc1
Show InChI InChI=1S/C20H23FN4O/c21-16-4-1-14(2-5-16)15-3-6-17(22)18(11-15)24-19(26)25-12-20(13-25)7-9-23-10-8-20/h1-6,11,23H,7-10,12-13,22H2,(H,24,26)
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n/an/an/a 2.75E+3n/an/an/an/an/a



Rodin Therapeutics, Inc.

US Patent


Assay Description
HDAC2 containing a C-terminal HIS-Tag (Proteros) and fluorescently-labeled anti-HIS-antibody are diluted in one vial in assay buffer 50 mM Tris, pH 8...


US Patent US10421756 (2019)


BindingDB Entry DOI: 10.7270/Q2PK0JGK
More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))
BDBM413987
PNG
(US10421756, Compound 171)
Show SMILES CC(C)(C)OC(=O)N1CCC2CN(CC2C1)C(=O)Nc1cc(ccc1N)-c1ccc(F)cc1
Show InChI InChI=1S/C25H31FN4O3/c1-25(2,3)33-24(32)29-11-10-18-13-30(15-19(18)14-29)23(31)28-22-12-17(6-9-21(22)27)16-4-7-20(26)8-5-16/h4-9,12,18-19H,10-11,13-15,27H2,1-3H3,(H,28,31)
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n/an/an/a 300n/an/an/an/an/a



Rodin Therapeutics, Inc.

US Patent


Assay Description
HDAC2 containing a C-terminal HIS-Tag (Proteros) and fluorescently-labeled anti-HIS-antibody are diluted in one vial in assay buffer 50 mM Tris, pH 8...


US Patent US10421756 (2019)


BindingDB Entry DOI: 10.7270/Q2PK0JGK
More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))
BDBM413989
PNG
(US10421756, Compound 173)
Show SMILES Nc1ccc(cc1NC(=O)N1CCC2(CCOC2)CC1)-c1ccc(F)cc1
Show InChI InChI=1S/C21H24FN3O2/c22-17-4-1-15(2-5-17)16-3-6-18(23)19(13-16)24-20(26)25-10-7-21(8-11-25)9-12-27-14-21/h1-6,13H,7-12,14,23H2,(H,24,26)
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n/an/an/a<100n/an/an/an/an/a



Rodin Therapeutics, Inc.

US Patent


Assay Description
HDAC2 containing a C-terminal HIS-Tag (Proteros) and fluorescently-labeled anti-HIS-antibody are diluted in one vial in assay buffer 50 mM Tris, pH 8...


US Patent US10421756 (2019)


BindingDB Entry DOI: 10.7270/Q2PK0JGK
More data for this
Ligand-Target Pair
Histone deacetylase 2


(Homo sapiens (Human))
BDBM413990
PNG
(US10421756, Compound 174)
Show SMILES Nc1ccc(cc1NC(=O)c1nc2CNCCc2s1)-c1ccncc1
Show InChI InChI=1S/C18H17N5OS/c19-13-2-1-12(11-3-6-20-7-4-11)9-14(13)22-17(24)18-23-15-10-21-8-5-16(15)25-18/h1-4,6-7,9,21H,5,8,10,19H2,(H,22,24)
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n/an/an/a<100n/an/an/an/an/a



Rodin Therapeutics, Inc.

US Patent


Assay Description
HDAC2 containing a C-terminal HIS-Tag (Proteros) and fluorescently-labeled anti-HIS-antibody are diluted in one vial in assay buffer 50 mM Tris, pH 8...


US Patent US10421756 (2019)


BindingDB Entry DOI: 10.7270/Q2PK0JGK
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%