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Patent code US10421760

Compile Data Set for Download or QSAR
Found 61 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))
BDBM153227
PNG
(US10421760, Comparative Example 12 | US8993756, 20...)
Show SMILES C=CC(=O)Nc1cccc(c1)-c1ncnc2[nH]cc(-c3ccccc3)c12
Show InChI InChI=1S/C21H16N4O/c1-2-18(26)25-16-10-6-9-15(11-16)20-19-17(14-7-4-3-5-8-14)12-22-21(19)24-13-23-20/h2-13H,1H2,(H,25,26)(H,22,23,24)
PDB

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Similars

US Patent
n/an/a 0.0900n/an/an/an/an/an/a



TAIHO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
JAK3: Among materials for the measurement of this inhibiting activity, a substrate peptide and a kinase protein were acquired as follows. As such a s...


US Patent US10421760 (2019)


BindingDB Entry DOI: 10.7270/Q2JS9SSR
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))
BDBM414003
PNG
(US10421760, Compound 14)
Show SMILES C=CC(=O)NC1CCCC(=C1)c1ncnc2[nH]cc(-c3ccsc3)c12
PDB

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n/an/a<0.300n/an/an/an/an/an/a



TAIHO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
JAK3: Among materials for the measurement of this inhibiting activity, a substrate peptide and a kinase protein were acquired as follows. As such a s...


US Patent US10421760 (2019)


BindingDB Entry DOI: 10.7270/Q2JS9SSR
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))
BDBM413998
PNG
(US10421760, Compound 8)
Show SMILES C=CC(=O)NC1CC=C(C1)c1ncnc2[nH]cc(-c3ccco3)c12
PDB

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n/an/a<0.300n/an/an/an/an/an/a



TAIHO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
JAK3: Among materials for the measurement of this inhibiting activity, a substrate peptide and a kinase protein were acquired as follows. As such a s...


US Patent US10421760 (2019)


BindingDB Entry DOI: 10.7270/Q2JS9SSR
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))
BDBM413993
PNG
(US10421760, Compound 2)
Show SMILES C=CC(=O)NC1CCC=C(C1)c1ncnc2[nH]cc(-c3cccs3)c12
PDB

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n/an/a<0.300n/an/an/an/an/an/a



TAIHO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
JAK3: Among materials for the measurement of this inhibiting activity, a substrate peptide and a kinase protein were acquired as follows. As such a s...


US Patent US10421760 (2019)


BindingDB Entry DOI: 10.7270/Q2JS9SSR
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))
BDBM413992
PNG
(US10421760, Compound 1)
Show SMILES C=CC(=O)NC1CCC=C(C1)c1ncnc2[nH]cc(-c3ccccc3)c12
PDB

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n/an/a<0.300n/an/an/an/an/an/a



TAIHO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
JAK3: Among materials for the measurement of this inhibiting activity, a substrate peptide and a kinase protein were acquired as follows. As such a s...


US Patent US10421760 (2019)


BindingDB Entry DOI: 10.7270/Q2JS9SSR
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))
BDBM413994
PNG
(US10421760, Compound 3)
Show SMILES C=CC(=O)NC1CCC=C(C1)c1ncnc2[nH]cc(-c3ccsc3)c12
PDB

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n/an/a<0.300n/an/an/an/an/an/a



TAIHO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
JAK3: Among materials for the measurement of this inhibiting activity, a substrate peptide and a kinase protein were acquired as follows. As such a s...


US Patent US10421760 (2019)


BindingDB Entry DOI: 10.7270/Q2JS9SSR
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))
BDBM413997
PNG
(US10421760, Compound 7)
Show SMILES C=CC(=O)N[C@H]1CCC=C(C1)c1ncnc2[nH]cc(-c3ccco3)c12
PDB

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n/an/a<0.300n/an/an/an/an/an/a



TAIHO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
JAK3: Among materials for the measurement of this inhibiting activity, a substrate peptide and a kinase protein were acquired as follows. As such a s...


US Patent US10421760 (2019)


BindingDB Entry DOI: 10.7270/Q2JS9SSR
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))
BDBM413999
PNG
(US10421760, Compound 9)
Show SMILES C=CC(=O)NC1CC=C(C1)c1ncnc2[nH]cc(-c3ccccc3)c12
PDB

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n/an/a<0.300n/an/an/an/an/an/a



TAIHO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
JAK3: Among materials for the measurement of this inhibiting activity, a substrate peptide and a kinase protein were acquired as follows. As such a s...


US Patent US10421760 (2019)


BindingDB Entry DOI: 10.7270/Q2JS9SSR
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))
BDBM414002
PNG
(US10421760, Compound 13)
Show SMILES C=CC(=O)NC1CCCC(=C1)c1ncnc2[nH]cc(-c3cccs3)c12
PDB

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n/an/a<0.300n/an/an/an/an/an/a



TAIHO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
JAK3: Among materials for the measurement of this inhibiting activity, a substrate peptide and a kinase protein were acquired as follows. As such a s...


US Patent US10421760 (2019)


BindingDB Entry DOI: 10.7270/Q2JS9SSR
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))
BDBM413996
PNG
(US10421760, Compound 5)
Show SMILES C=CC(=O)NC1CCC=C(C1)c1ncnc2[nH]cc(-c3ccco3)c12
PDB

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n/an/a<0.300n/an/an/an/an/an/a



TAIHO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
JAK3: Among materials for the measurement of this inhibiting activity, a substrate peptide and a kinase protein were acquired as follows. As such a s...


US Patent US10421760 (2019)


BindingDB Entry DOI: 10.7270/Q2JS9SSR
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))
BDBM414004
PNG
(US10421760, Compound 15)
Show SMILES C=CC(=O)NC1CCCC(=C1)c1ncnc2[nH]cc(-c3ccco3)c12
PDB

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n/an/a 0.330n/an/an/an/an/an/a



TAIHO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
JAK3: Among materials for the measurement of this inhibiting activity, a substrate peptide and a kinase protein were acquired as follows. As such a s...


US Patent US10421760 (2019)


BindingDB Entry DOI: 10.7270/Q2JS9SSR
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))
BDBM414001
PNG
(US10421760, Compound 12)
Show SMILES C=CC(=O)NC1CCCC(=C1)c1ncnc2[nH]cc(-c3ccccc3)c12
PDB

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n/an/a 0.350n/an/an/an/an/an/a



TAIHO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
JAK3: Among materials for the measurement of this inhibiting activity, a substrate peptide and a kinase protein were acquired as follows. As such a s...


US Patent US10421760 (2019)


BindingDB Entry DOI: 10.7270/Q2JS9SSR
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))
BDBM413995
PNG
(US10421760, Compound 4)
Show SMILES C=CC(=O)NC1CCC=C(C1)c1ncnc2[nH]cc(-c3ccoc3)c12
PDB

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n/an/a 0.420n/an/an/an/an/an/a



TAIHO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
JAK3: Among materials for the measurement of this inhibiting activity, a substrate peptide and a kinase protein were acquired as follows. As such a s...


US Patent US10421760 (2019)


BindingDB Entry DOI: 10.7270/Q2JS9SSR
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))
BDBM414000
PNG
(US10421760, Compound 10)
Show SMILES C=CC(=O)NC1CCC(=C1)c1ncnc2[nH]cc(-c3ccccc3)c12
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n/an/a 0.680n/an/an/an/an/an/a



TAIHO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
JAK3: Among materials for the measurement of this inhibiting activity, a substrate peptide and a kinase protein were acquired as follows. As such a s...


US Patent US10421760 (2019)


BindingDB Entry DOI: 10.7270/Q2JS9SSR
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))
BDBM414005
PNG
(US10421760, Compound 16)
Show SMILES C=CC(=O)NC1CCCC(=C1)c1ncnc2[nH]cc(-c3ccoc3)c12
PDB

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n/an/a 0.770n/an/an/an/an/an/a



TAIHO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
JAK3: Among materials for the measurement of this inhibiting activity, a substrate peptide and a kinase protein were acquired as follows. As such a s...


US Patent US10421760 (2019)


BindingDB Entry DOI: 10.7270/Q2JS9SSR
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))
BDBM414010
PNG
(US10421760, Comparative Example 11(a) | US10421760...)
Show SMILES C=CC(=O)N[C@H]1CCCC(C1)c1ncnc2[nH]cc(-c3ccco3)c12
PDB

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n/an/a 19n/an/an/an/an/an/a



TAIHO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
JAK3: Among materials for the measurement of this inhibiting activity, a substrate peptide and a kinase protein were acquired as follows. As such a s...


US Patent US10421760 (2019)


BindingDB Entry DOI: 10.7270/Q2JS9SSR
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))
BDBM414010
PNG
(US10421760, Comparative Example 11(a) | US10421760...)
Show SMILES C=CC(=O)N[C@H]1CCCC(C1)c1ncnc2[nH]cc(-c3ccco3)c12
PDB

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n/an/a 21n/an/an/an/an/an/a



TAIHO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
JAK3: Among materials for the measurement of this inhibiting activity, a substrate peptide and a kinase protein were acquired as follows. As such a s...


US Patent US10421760 (2019)


BindingDB Entry DOI: 10.7270/Q2JS9SSR
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))
BDBM414008
PNG
(US10421760, Comparative Example 8)
Show SMILES C=CC(=O)NC1CCC=C(C1)c1ncnc2[nH]cc(-c3ncccn3)c12
PDB

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n/an/a 21.4n/an/an/an/an/an/a



TAIHO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
JAK3: Among materials for the measurement of this inhibiting activity, a substrate peptide and a kinase protein were acquired as follows. As such a s...


US Patent US10421760 (2019)


BindingDB Entry DOI: 10.7270/Q2JS9SSR
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))
BDBM414007
PNG
(US10421760, Comparative Example 2)
Show SMILES C\C=C\C(=O)NC1CCC=C(C1)c1ncnc2[nH]cc(-c3ccccc3)c12
PDB

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n/an/a 27n/an/an/an/an/an/a



TAIHO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
JAK3: Among materials for the measurement of this inhibiting activity, a substrate peptide and a kinase protein were acquired as follows. As such a s...


US Patent US10421760 (2019)


BindingDB Entry DOI: 10.7270/Q2JS9SSR
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))
BDBM414006
PNG
(US10421760, Comparative Example 1)
Show SMILES CC(=C)C(=O)NC1CCC=C(C1)c1ncnc2[nH]cc(-c3ccccc3)c12
PDB

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n/an/a 44n/an/an/an/an/an/a



TAIHO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
JAK3: Among materials for the measurement of this inhibiting activity, a substrate peptide and a kinase protein were acquired as follows. As such a s...


US Patent US10421760 (2019)


BindingDB Entry DOI: 10.7270/Q2JS9SSR
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))
BDBM414009
PNG
(US10421760, Comparative Example 10)
Show SMILES C1CCC(=CC1)c1ncnc2[nH]ccc12
Show InChI InChI=1S/C12H13N3/c1-2-4-9(5-3-1)11-10-6-7-13-12(10)15-8-14-11/h4,6-8H,1-3,5H2,(H,13,14,15)
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n/an/a 125n/an/an/an/an/an/a



TAIHO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
JAK3: Among materials for the measurement of this inhibiting activity, a substrate peptide and a kinase protein were acquired as follows. As such a s...


US Patent US10421760 (2019)


BindingDB Entry DOI: 10.7270/Q2JS9SSR
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM414009
PNG
(US10421760, Comparative Example 10)
Show SMILES C1CCC(=CC1)c1ncnc2[nH]ccc12
Show InChI InChI=1S/C12H13N3/c1-2-4-9(5-3-1)11-10-6-7-13-12(10)15-8-14-11/h4,6-8H,1-3,5H2,(H,13,14,15)
PDB

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n/an/a 166n/an/an/an/an/an/a



TAIHO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
JAK 2: Among materials for the measurement of this inhibiting activity, a substrate peptide and a kinase protein were acquired as follows. As such a ...


US Patent US10421760 (2019)


BindingDB Entry DOI: 10.7270/Q2JS9SSR
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM413997
PNG
(US10421760, Compound 7)
Show SMILES C=CC(=O)N[C@H]1CCC=C(C1)c1ncnc2[nH]cc(-c3ccco3)c12
PDB

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n/an/a 330n/an/an/an/an/an/a



TAIHO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
JAK 2: Among materials for the measurement of this inhibiting activity, a substrate peptide and a kinase protein were acquired as follows. As such a ...


US Patent US10421760 (2019)


BindingDB Entry DOI: 10.7270/Q2JS9SSR
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM414009
PNG
(US10421760, Comparative Example 10)
Show SMILES C1CCC(=CC1)c1ncnc2[nH]ccc12
Show InChI InChI=1S/C12H13N3/c1-2-4-9(5-3-1)11-10-6-7-13-12(10)15-8-14-11/h4,6-8H,1-3,5H2,(H,13,14,15)
PDB

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n/an/a 414n/an/an/an/an/an/a



TAIHO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
JAK 1: Among materials for the measurement of this inhibiting activity, a substrate peptide and a kinase protein were acquired as follows. As such a ...


US Patent US10421760 (2019)


BindingDB Entry DOI: 10.7270/Q2JS9SSR
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM413998
PNG
(US10421760, Compound 8)
Show SMILES C=CC(=O)NC1CC=C(C1)c1ncnc2[nH]cc(-c3ccco3)c12
PDB

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n/an/a 430n/an/an/an/an/an/a



TAIHO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
JAK 2: Among materials for the measurement of this inhibiting activity, a substrate peptide and a kinase protein were acquired as follows. As such a ...


US Patent US10421760 (2019)


BindingDB Entry DOI: 10.7270/Q2JS9SSR
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM413996
PNG
(US10421760, Compound 5)
Show SMILES C=CC(=O)NC1CCC=C(C1)c1ncnc2[nH]cc(-c3ccco3)c12
PDB

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n/an/a 430n/an/an/an/an/an/a



TAIHO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
JAK 2: Among materials for the measurement of this inhibiting activity, a substrate peptide and a kinase protein were acquired as follows. As such a ...


US Patent US10421760 (2019)


BindingDB Entry DOI: 10.7270/Q2JS9SSR
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM413997
PNG
(US10421760, Compound 7)
Show SMILES C=CC(=O)N[C@H]1CCC=C(C1)c1ncnc2[nH]cc(-c3ccco3)c12
PDB

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n/an/a 440n/an/an/an/an/an/a



TAIHO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
JAK 1: Among materials for the measurement of this inhibiting activity, a substrate peptide and a kinase protein were acquired as follows. As such a ...


US Patent US10421760 (2019)


BindingDB Entry DOI: 10.7270/Q2JS9SSR
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM414004
PNG
(US10421760, Compound 15)
Show SMILES C=CC(=O)NC1CCCC(=C1)c1ncnc2[nH]cc(-c3ccco3)c12
PDB

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n/an/a 450n/an/an/an/an/an/a



TAIHO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
JAK 2: Among materials for the measurement of this inhibiting activity, a substrate peptide and a kinase protein were acquired as follows. As such a ...


US Patent US10421760 (2019)


BindingDB Entry DOI: 10.7270/Q2JS9SSR
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM413992
PNG
(US10421760, Compound 1)
Show SMILES C=CC(=O)NC1CCC=C(C1)c1ncnc2[nH]cc(-c3ccccc3)c12
PDB

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n/an/a 470n/an/an/an/an/an/a



TAIHO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
JAK 2: Among materials for the measurement of this inhibiting activity, a substrate peptide and a kinase protein were acquired as follows. As such a ...


US Patent US10421760 (2019)


BindingDB Entry DOI: 10.7270/Q2JS9SSR
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM413993
PNG
(US10421760, Compound 2)
Show SMILES C=CC(=O)NC1CCC=C(C1)c1ncnc2[nH]cc(-c3cccs3)c12
PDB

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n/an/a 480n/an/an/an/an/an/a



TAIHO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
JAK 2: Among materials for the measurement of this inhibiting activity, a substrate peptide and a kinase protein were acquired as follows. As such a ...


US Patent US10421760 (2019)


BindingDB Entry DOI: 10.7270/Q2JS9SSR
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM414002
PNG
(US10421760, Compound 13)
Show SMILES C=CC(=O)NC1CCCC(=C1)c1ncnc2[nH]cc(-c3cccs3)c12
PDB

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n/an/a 490n/an/an/an/an/an/a



TAIHO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
JAK 2: Among materials for the measurement of this inhibiting activity, a substrate peptide and a kinase protein were acquired as follows. As such a ...


US Patent US10421760 (2019)


BindingDB Entry DOI: 10.7270/Q2JS9SSR
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM414007
PNG
(US10421760, Comparative Example 2)
Show SMILES C\C=C\C(=O)NC1CCC=C(C1)c1ncnc2[nH]cc(-c3ccccc3)c12
PDB

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n/an/a 600n/an/an/an/an/an/a



TAIHO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
JAK 2: Among materials for the measurement of this inhibiting activity, a substrate peptide and a kinase protein were acquired as follows. As such a ...


US Patent US10421760 (2019)


BindingDB Entry DOI: 10.7270/Q2JS9SSR
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM414000
PNG
(US10421760, Compound 10)
Show SMILES C=CC(=O)NC1CCC(=C1)c1ncnc2[nH]cc(-c3ccccc3)c12
PDB

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n/an/a 660n/an/an/an/an/an/a



TAIHO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
JAK 2: Among materials for the measurement of this inhibiting activity, a substrate peptide and a kinase protein were acquired as follows. As such a ...


US Patent US10421760 (2019)


BindingDB Entry DOI: 10.7270/Q2JS9SSR
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM413996
PNG
(US10421760, Compound 5)
Show SMILES C=CC(=O)NC1CCC=C(C1)c1ncnc2[nH]cc(-c3ccco3)c12
PDB

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n/an/a 720n/an/an/an/an/an/a



TAIHO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
JAK 1: Among materials for the measurement of this inhibiting activity, a substrate peptide and a kinase protein were acquired as follows. As such a ...


US Patent US10421760 (2019)


BindingDB Entry DOI: 10.7270/Q2JS9SSR
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM414007
PNG
(US10421760, Comparative Example 2)
Show SMILES C\C=C\C(=O)NC1CCC=C(C1)c1ncnc2[nH]cc(-c3ccccc3)c12
PDB

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n/an/a 730n/an/an/an/an/an/a



TAIHO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
JAK 1: Among materials for the measurement of this inhibiting activity, a substrate peptide and a kinase protein were acquired as follows. As such a ...


US Patent US10421760 (2019)


BindingDB Entry DOI: 10.7270/Q2JS9SSR
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM413994
PNG
(US10421760, Compound 3)
Show SMILES C=CC(=O)NC1CCC=C(C1)c1ncnc2[nH]cc(-c3ccsc3)c12
PDB

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n/an/a 850n/an/an/an/an/an/a



TAIHO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
JAK 2: Among materials for the measurement of this inhibiting activity, a substrate peptide and a kinase protein were acquired as follows. As such a ...


US Patent US10421760 (2019)


BindingDB Entry DOI: 10.7270/Q2JS9SSR
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM414001
PNG
(US10421760, Compound 12)
Show SMILES C=CC(=O)NC1CCCC(=C1)c1ncnc2[nH]cc(-c3ccccc3)c12
PDB

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n/an/a 870n/an/an/an/an/an/a



TAIHO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
JAK 2: Among materials for the measurement of this inhibiting activity, a substrate peptide and a kinase protein were acquired as follows. As such a ...


US Patent US10421760 (2019)


BindingDB Entry DOI: 10.7270/Q2JS9SSR
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM414006
PNG
(US10421760, Comparative Example 1)
Show SMILES CC(=C)C(=O)NC1CCC=C(C1)c1ncnc2[nH]cc(-c3ccccc3)c12
PDB

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n/an/a 880n/an/an/an/an/an/a



TAIHO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
JAK 1: Among materials for the measurement of this inhibiting activity, a substrate peptide and a kinase protein were acquired as follows. As such a ...


US Patent US10421760 (2019)


BindingDB Entry DOI: 10.7270/Q2JS9SSR
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM414010
PNG
(US10421760, Comparative Example 11(a) | US10421760...)
Show SMILES C=CC(=O)N[C@H]1CCCC(C1)c1ncnc2[nH]cc(-c3ccco3)c12
PDB

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n/an/a 880n/an/an/an/an/an/a



TAIHO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
JAK 2: Among materials for the measurement of this inhibiting activity, a substrate peptide and a kinase protein were acquired as follows. As such a ...


US Patent US10421760 (2019)


BindingDB Entry DOI: 10.7270/Q2JS9SSR
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM413999
PNG
(US10421760, Compound 9)
Show SMILES C=CC(=O)NC1CC=C(C1)c1ncnc2[nH]cc(-c3ccccc3)c12
PDB

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n/an/a 880n/an/an/an/an/an/a



TAIHO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
JAK 2: Among materials for the measurement of this inhibiting activity, a substrate peptide and a kinase protein were acquired as follows. As such a ...


US Patent US10421760 (2019)


BindingDB Entry DOI: 10.7270/Q2JS9SSR
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM413992
PNG
(US10421760, Compound 1)
Show SMILES C=CC(=O)NC1CCC=C(C1)c1ncnc2[nH]cc(-c3ccccc3)c12
PDB

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n/an/a 880n/an/an/an/an/an/a



TAIHO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
JAK 1: Among materials for the measurement of this inhibiting activity, a substrate peptide and a kinase protein were acquired as follows. As such a ...


US Patent US10421760 (2019)


BindingDB Entry DOI: 10.7270/Q2JS9SSR
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM413993
PNG
(US10421760, Compound 2)
Show SMILES C=CC(=O)NC1CCC=C(C1)c1ncnc2[nH]cc(-c3cccs3)c12
PDB

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n/an/a 900n/an/an/an/an/an/a



TAIHO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
JAK 1: Among materials for the measurement of this inhibiting activity, a substrate peptide and a kinase protein were acquired as follows. As such a ...


US Patent US10421760 (2019)


BindingDB Entry DOI: 10.7270/Q2JS9SSR
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM414005
PNG
(US10421760, Compound 16)
Show SMILES C=CC(=O)NC1CCCC(=C1)c1ncnc2[nH]cc(-c3ccoc3)c12
PDB

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n/an/a 1.00E+3n/an/an/an/an/an/a



TAIHO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
JAK 2: Among materials for the measurement of this inhibiting activity, a substrate peptide and a kinase protein were acquired as follows. As such a ...


US Patent US10421760 (2019)


BindingDB Entry DOI: 10.7270/Q2JS9SSR
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM153227
PNG
(US10421760, Comparative Example 12 | US8993756, 20...)
Show SMILES C=CC(=O)Nc1cccc(c1)-c1ncnc2[nH]cc(-c3ccccc3)c12
Show InChI InChI=1S/C21H16N4O/c1-2-18(26)25-16-10-6-9-15(11-16)20-19-17(14-7-4-3-5-8-14)12-22-21(19)24-13-23-20/h2-13H,1H2,(H,25,26)(H,22,23,24)
PDB

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n/an/a>1.00E+3n/an/an/an/an/an/a



TAIHO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
JAK 1: Among materials for the measurement of this inhibiting activity, a substrate peptide and a kinase protein were acquired as follows. As such a ...


US Patent US10421760 (2019)


BindingDB Entry DOI: 10.7270/Q2JS9SSR
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM153227
PNG
(US10421760, Comparative Example 12 | US8993756, 20...)
Show SMILES C=CC(=O)Nc1cccc(c1)-c1ncnc2[nH]cc(-c3ccccc3)c12
Show InChI InChI=1S/C21H16N4O/c1-2-18(26)25-16-10-6-9-15(11-16)20-19-17(14-7-4-3-5-8-14)12-22-21(19)24-13-23-20/h2-13H,1H2,(H,25,26)(H,22,23,24)
PDB

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n/an/a>1.00E+3n/an/an/an/an/an/a



TAIHO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
JAK 2: Among materials for the measurement of this inhibiting activity, a substrate peptide and a kinase protein were acquired as follows. As such a ...


US Patent US10421760 (2019)


BindingDB Entry DOI: 10.7270/Q2JS9SSR
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM414006
PNG
(US10421760, Comparative Example 1)
Show SMILES CC(=C)C(=O)NC1CCC=C(C1)c1ncnc2[nH]cc(-c3ccccc3)c12
PDB

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n/an/a 1.10E+3n/an/an/an/an/an/a



TAIHO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
JAK 2: Among materials for the measurement of this inhibiting activity, a substrate peptide and a kinase protein were acquired as follows. As such a ...


US Patent US10421760 (2019)


BindingDB Entry DOI: 10.7270/Q2JS9SSR
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM414003
PNG
(US10421760, Compound 14)
Show SMILES C=CC(=O)NC1CCCC(=C1)c1ncnc2[nH]cc(-c3ccsc3)c12
PDB

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n/an/a 1.20E+3n/an/an/an/an/an/a



TAIHO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
JAK 2: Among materials for the measurement of this inhibiting activity, a substrate peptide and a kinase protein were acquired as follows. As such a ...


US Patent US10421760 (2019)


BindingDB Entry DOI: 10.7270/Q2JS9SSR
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM413995
PNG
(US10421760, Compound 4)
Show SMILES C=CC(=O)NC1CCC=C(C1)c1ncnc2[nH]cc(-c3ccoc3)c12
PDB

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n/an/a 1.30E+3n/an/an/an/an/an/a



TAIHO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
JAK 2: Among materials for the measurement of this inhibiting activity, a substrate peptide and a kinase protein were acquired as follows. As such a ...


US Patent US10421760 (2019)


BindingDB Entry DOI: 10.7270/Q2JS9SSR
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM413998
PNG
(US10421760, Compound 8)
Show SMILES C=CC(=O)NC1CC=C(C1)c1ncnc2[nH]cc(-c3ccco3)c12
PDB

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n/an/a 1.40E+3n/an/an/an/an/an/a



TAIHO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
JAK 1: Among materials for the measurement of this inhibiting activity, a substrate peptide and a kinase protein were acquired as follows. As such a ...


US Patent US10421760 (2019)


BindingDB Entry DOI: 10.7270/Q2JS9SSR
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM413994
PNG
(US10421760, Compound 3)
Show SMILES C=CC(=O)NC1CCC=C(C1)c1ncnc2[nH]cc(-c3ccsc3)c12
PDB

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n/an/a 1.50E+3n/an/an/an/an/an/a



TAIHO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
JAK 1: Among materials for the measurement of this inhibiting activity, a substrate peptide and a kinase protein were acquired as follows. As such a ...


US Patent US10421760 (2019)


BindingDB Entry DOI: 10.7270/Q2JS9SSR
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM413999
PNG
(US10421760, Compound 9)
Show SMILES C=CC(=O)NC1CC=C(C1)c1ncnc2[nH]cc(-c3ccccc3)c12
PDB

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n/an/a 2.10E+3n/an/an/an/an/an/a



TAIHO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
JAK 1: Among materials for the measurement of this inhibiting activity, a substrate peptide and a kinase protein were acquired as follows. As such a ...


US Patent US10421760 (2019)


BindingDB Entry DOI: 10.7270/Q2JS9SSR
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM414010
PNG
(US10421760, Comparative Example 11(a) | US10421760...)
Show SMILES C=CC(=O)N[C@H]1CCCC(C1)c1ncnc2[nH]cc(-c3ccco3)c12
PDB

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n/an/a 2.44E+3n/an/an/an/an/an/a



TAIHO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
JAK 2: Among materials for the measurement of this inhibiting activity, a substrate peptide and a kinase protein were acquired as follows. As such a ...


US Patent US10421760 (2019)


BindingDB Entry DOI: 10.7270/Q2JS9SSR
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM414004
PNG
(US10421760, Compound 15)
Show SMILES C=CC(=O)NC1CCCC(=C1)c1ncnc2[nH]cc(-c3ccco3)c12
PDB

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n/an/a 2.60E+3n/an/an/an/an/an/a



TAIHO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
JAK 1: Among materials for the measurement of this inhibiting activity, a substrate peptide and a kinase protein were acquired as follows. As such a ...


US Patent US10421760 (2019)


BindingDB Entry DOI: 10.7270/Q2JS9SSR
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM413995
PNG
(US10421760, Compound 4)
Show SMILES C=CC(=O)NC1CCC=C(C1)c1ncnc2[nH]cc(-c3ccoc3)c12
PDB

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n/an/a 2.90E+3n/an/an/an/an/an/a



TAIHO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
JAK 1: Among materials for the measurement of this inhibiting activity, a substrate peptide and a kinase protein were acquired as follows. As such a ...


US Patent US10421760 (2019)


BindingDB Entry DOI: 10.7270/Q2JS9SSR
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM414002
PNG
(US10421760, Compound 13)
Show SMILES C=CC(=O)NC1CCCC(=C1)c1ncnc2[nH]cc(-c3cccs3)c12
PDB

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n/an/a 3.20E+3n/an/an/an/an/an/a



TAIHO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
JAK 1: Among materials for the measurement of this inhibiting activity, a substrate peptide and a kinase protein were acquired as follows. As such a ...


US Patent US10421760 (2019)


BindingDB Entry DOI: 10.7270/Q2JS9SSR
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM414001
PNG
(US10421760, Compound 12)
Show SMILES C=CC(=O)NC1CCCC(=C1)c1ncnc2[nH]cc(-c3ccccc3)c12
PDB

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n/an/a 3.20E+3n/an/an/an/an/an/a



TAIHO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
JAK 1: Among materials for the measurement of this inhibiting activity, a substrate peptide and a kinase protein were acquired as follows. As such a ...


US Patent US10421760 (2019)


BindingDB Entry DOI: 10.7270/Q2JS9SSR
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM414005
PNG
(US10421760, Compound 16)
Show SMILES C=CC(=O)NC1CCCC(=C1)c1ncnc2[nH]cc(-c3ccoc3)c12
PDB

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n/an/a 4.90E+3n/an/an/an/an/an/a



TAIHO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
JAK 1: Among materials for the measurement of this inhibiting activity, a substrate peptide and a kinase protein were acquired as follows. As such a ...


US Patent US10421760 (2019)


BindingDB Entry DOI: 10.7270/Q2JS9SSR
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM414003
PNG
(US10421760, Compound 14)
Show SMILES C=CC(=O)NC1CCCC(=C1)c1ncnc2[nH]cc(-c3ccsc3)c12
PDB

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UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 5.60E+3n/an/an/an/an/an/a



TAIHO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
JAK 1: Among materials for the measurement of this inhibiting activity, a substrate peptide and a kinase protein were acquired as follows. As such a ...


US Patent US10421760 (2019)


BindingDB Entry DOI: 10.7270/Q2JS9SSR
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM414008
PNG
(US10421760, Comparative Example 8)
Show SMILES C=CC(=O)NC1CCC=C(C1)c1ncnc2[nH]cc(-c3ncccn3)c12
PDB

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UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a>1.00E+4n/an/an/an/an/an/a



TAIHO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
JAK 2: Among materials for the measurement of this inhibiting activity, a substrate peptide and a kinase protein were acquired as follows. As such a ...


US Patent US10421760 (2019)


BindingDB Entry DOI: 10.7270/Q2JS9SSR
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM414010
PNG
(US10421760, Comparative Example 11(a) | US10421760...)
Show SMILES C=CC(=O)N[C@H]1CCCC(C1)c1ncnc2[nH]cc(-c3ccco3)c12
PDB

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KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a>1.00E+4n/an/an/an/an/an/a



TAIHO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
JAK 1: Among materials for the measurement of this inhibiting activity, a substrate peptide and a kinase protein were acquired as follows. As such a ...


US Patent US10421760 (2019)


BindingDB Entry DOI: 10.7270/Q2JS9SSR
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM414010
PNG
(US10421760, Comparative Example 11(a) | US10421760...)
Show SMILES C=CC(=O)N[C@H]1CCCC(C1)c1ncnc2[nH]cc(-c3ccco3)c12
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a>1.00E+4n/an/an/an/an/an/a



TAIHO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
JAK 1: Among materials for the measurement of this inhibiting activity, a substrate peptide and a kinase protein were acquired as follows. As such a ...


US Patent US10421760 (2019)


BindingDB Entry DOI: 10.7270/Q2JS9SSR
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%