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Patent code US10428074

Compile Data Set for Download or QSAR
Found 130 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM260459
PNG
(US10428074, Example 17 | US9527851, 17 | US9527851...)
Show SMILES C[C@H](O)C(=O)N1C[C@@H]2C[C@H](C[C@@H]2C1)N(C)c1ncnc2[nH]ccc12
PDB

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n/an/a 0.200n/an/an/an/an/an/a



Jiangsu Hengrui Medicine Co., Ltd.

US Patent


Assay Description
JAK1: In vitro kinase assays described below can be used to determine the activity of a test compound for inhibiting the activity of JAK1 kinase. The...


US Patent US10428074 (2019)


BindingDB Entry DOI: 10.7270/Q26D5WC6
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM260478
PNG
(US10428074, Example 125 | US9527851, 125 | US95278...)
Show SMILES CN([C@@H]1C[C@H]2CN(C[C@H]2C1)C(=O)Nc1nc(ns1)C1CC1)c1ncnc2[nH]ccc12
PDB

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Jiangsu Hengrui Medicine Co., Ltd.

US Patent


Assay Description
JAK1: In vitro kinase assays described below can be used to determine the activity of a test compound for inhibiting the activity of JAK1 kinase. The...


US Patent US10428074 (2019)


BindingDB Entry DOI: 10.7270/Q26D5WC6
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM260478
PNG
(US10428074, Example 125 | US9527851, 125 | US95278...)
Show SMILES CN([C@@H]1C[C@H]2CN(C[C@H]2C1)C(=O)Nc1nc(ns1)C1CC1)c1ncnc2[nH]ccc12
PDB

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n/an/a 0.200n/an/an/an/an/an/a



Jiangsu Hengrui Medicine Co., Ltd.

US Patent


Assay Description
JAK1: In vitro kinase assays described below can be used to determine the activity of a test compound for inhibiting the activity of JAK1 kinase. The...


US Patent US10428074 (2019)


BindingDB Entry DOI: 10.7270/Q26D5WC6
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM415495
PNG
(US10428074, Example 99)
Show SMILES CN([C@@H]1C[C@H]2CN(C[C@H]2C1)C(=O)Nc1nc(OCC(C)(C)O)ns1)c1ncnc2[nH]ccc12
PDB

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Jiangsu Hengrui Medicine Co., Ltd.

US Patent


Assay Description
JAK1: In vitro kinase assays described below can be used to determine the activity of a test compound for inhibiting the activity of JAK1 kinase. The...


US Patent US10428074 (2019)


BindingDB Entry DOI: 10.7270/Q26D5WC6
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))
BDBM260459
PNG
(US10428074, Example 17 | US9527851, 17 | US9527851...)
Show SMILES C[C@H](O)C(=O)N1C[C@@H]2C[C@H](C[C@@H]2C1)N(C)c1ncnc2[nH]ccc12
PDB

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n/an/a 0.300n/an/an/an/an/an/a



Jiangsu Hengrui Medicine Co., Ltd.

US Patent


Assay Description
JAK3: In vitro kinase assays described below can be used to determine the activity of a test compound for inhibiting the activity of JAK3 kinase. The...


US Patent US10428074 (2019)


BindingDB Entry DOI: 10.7270/Q26D5WC6
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM415473
PNG
((3aR,5S,6aS)?N-(3-(Hydroxymethyl)-1,2,4-thiadiazol...)
Show SMILES CN([C@@H]1C[C@H]2CN(C[C@H]2C1)C(=O)Nc1nc(CO)ns1)c1ncnc2[nH]ccc12
PDB

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n/an/a 0.5n/an/an/an/an/an/a



Jiangsu Hengrui Medicine Co., Ltd.

US Patent


Assay Description
JAK1: In vitro kinase assays described below can be used to determine the activity of a test compound for inhibiting the activity of JAK1 kinase. The...


US Patent US10428074 (2019)


BindingDB Entry DOI: 10.7270/Q26D5WC6
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM260475
PNG
(US10428074, Example 147 | US9527851, 147 | US95278...)
Show SMILES CN([C@H]1C[C@H]2CNC(=O)C[C@H]2C1)c1ncnc2[nH]ccc12
PDB

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Jiangsu Hengrui Medicine Co., Ltd.

US Patent


Assay Description
JAK1: In vitro kinase assays described below can be used to determine the activity of a test compound for inhibiting the activity of JAK1 kinase. The...


US Patent US10428074 (2019)


BindingDB Entry DOI: 10.7270/Q26D5WC6
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM260477
PNG
(US10428074, Example 121 | US9527851, 121 | US95278...)
Show SMILES CCc1nsc(NC(=O)N2C[C@@H]3C[C@H](C[C@@H]3C2)N(C)c2ncnc3[nH]ccc23)n1
PDB

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Jiangsu Hengrui Medicine Co., Ltd.

US Patent


Assay Description
JAK1: In vitro kinase assays described below can be used to determine the activity of a test compound for inhibiting the activity of JAK1 kinase. The...


US Patent US10428074 (2019)


BindingDB Entry DOI: 10.7270/Q26D5WC6
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM260477
PNG
(US10428074, Example 121 | US9527851, 121 | US95278...)
Show SMILES CCc1nsc(NC(=O)N2C[C@@H]3C[C@H](C[C@@H]3C2)N(C)c2ncnc3[nH]ccc23)n1
PDB

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Jiangsu Hengrui Medicine Co., Ltd.

US Patent


Assay Description
JAK1: In vitro kinase assays described below can be used to determine the activity of a test compound for inhibiting the activity of JAK1 kinase. The...


US Patent US10428074 (2019)


BindingDB Entry DOI: 10.7270/Q26D5WC6
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM260518
PNG
(US10428074, Example 135 | US9527851, 135 | US95278...)
Show SMILES CN(C[C@H]1[C@@H]2CN(C[C@H]12)C(=O)C1CC1)c1ncnc2[nH]ccc12
PDB

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Jiangsu Hengrui Medicine Co., Ltd.

US Patent


Assay Description
JAK2: In vitro kinase assays described below can be used to determine the activity of a test compound for inhibiting the activity of JAK2 kinase. The...


US Patent US10428074 (2019)


BindingDB Entry DOI: 10.7270/Q26D5WC6
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM260508
PNG
(US10428074, Example 114 | US9527851, 114 | US95278...)
Show SMILES CN([C@@H]1C[C@H]2CN(C[C@H]2C1)C(=O)Nc1nc(C)ns1)c1ccnc2[nH]ccc12
PDB

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Jiangsu Hengrui Medicine Co., Ltd.

US Patent


Assay Description
JAK1: In vitro kinase assays described below can be used to determine the activity of a test compound for inhibiting the activity of JAK1 kinase. The...


US Patent US10428074 (2019)


BindingDB Entry DOI: 10.7270/Q26D5WC6
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM260469
PNG
(US10428074, Example 34 | US9527851, 34 | US9527851...)
Show SMILES COc1nsc(NC(=O)N2C[C@@H]3C[C@H](C[C@@H]3C2)N(C)c2ncnc3[nH]ccc23)n1
PDB

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Jiangsu Hengrui Medicine Co., Ltd.

US Patent


Assay Description
JAK1: In vitro kinase assays described below can be used to determine the activity of a test compound for inhibiting the activity of JAK1 kinase. The...


US Patent US10428074 (2019)


BindingDB Entry DOI: 10.7270/Q26D5WC6
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM260459
PNG
(US10428074, Example 17 | US9527851, 17 | US9527851...)
Show SMILES C[C@H](O)C(=O)N1C[C@@H]2C[C@H](C[C@@H]2C1)N(C)c1ncnc2[nH]ccc12
PDB

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Jiangsu Hengrui Medicine Co., Ltd.

US Patent


Assay Description
JAK2: In vitro kinase assays described below can be used to determine the activity of a test compound for inhibiting the activity of JAK2 kinase. The...


US Patent US10428074 (2019)


BindingDB Entry DOI: 10.7270/Q26D5WC6
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM260470
PNG
(US10428074, Example 35 | US9527851, 35)
Show SMILES CN(C1C[C@@H]2CCN(C[C@@H]2C1)C(C)=O)c1ncnc2[nH]ccc12
PDB

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Jiangsu Hengrui Medicine Co., Ltd.

US Patent


Assay Description
JAK1: In vitro kinase assays described below can be used to determine the activity of a test compound for inhibiting the activity of JAK1 kinase. The...


US Patent US10428074 (2019)


BindingDB Entry DOI: 10.7270/Q26D5WC6
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM260485
PNG
(US10428074, Example 69 | US9527851, 69 | US9527851...)
Show SMILES CN([C@H]1C[C@H]2CN(CC#N)C[C@H]2C1)c1ncnc2[nH]ccc12
PDB

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Jiangsu Hengrui Medicine Co., Ltd.

US Patent


Assay Description
JAK2: In vitro kinase assays described below can be used to determine the activity of a test compound for inhibiting the activity of JAK2 kinase. The...


US Patent US10428074 (2019)


BindingDB Entry DOI: 10.7270/Q26D5WC6
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))
BDBM415507
PNG
(US10428074, Example 128)
Show SMILES CN([C@@H]1C[C@H]2CN(C[C@H]2C1)C(=O)CO)c1ncnc2[nH]cc(F)c12
PDB

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Jiangsu Hengrui Medicine Co., Ltd.

US Patent


Assay Description
JAK3: In vitro kinase assays described below can be used to determine the activity of a test compound for inhibiting the activity of JAK3 kinase. The...


US Patent US10428074 (2019)


BindingDB Entry DOI: 10.7270/Q26D5WC6
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM415513
PNG
(US10428074, Example 155)
Show SMILES COc1nnc(NC(=O)N2C[C@@H]3C[C@H](C[C@@H]3C2)N(C)c2ncnc3[nH]ccc23)s1
PDB

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Jiangsu Hengrui Medicine Co., Ltd.

US Patent


Assay Description
JAK1: In vitro kinase assays described below can be used to determine the activity of a test compound for inhibiting the activity of JAK1 kinase. The...


US Patent US10428074 (2019)


BindingDB Entry DOI: 10.7270/Q26D5WC6
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM260489
PNG
(US10428074, Example 74 | US9527851, 74 | US9527851...)
Show SMILES COc1nsc(NC(=O)N2C[C@@H]3C[C@@H](C[C@@H]3C2)N(C)c2ncnc3[nH]ccc23)n1
PDB

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Jiangsu Hengrui Medicine Co., Ltd.

US Patent


Assay Description
JAK1: In vitro kinase assays described below can be used to determine the activity of a test compound for inhibiting the activity of JAK1 kinase. The...


US Patent US10428074 (2019)


BindingDB Entry DOI: 10.7270/Q26D5WC6
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM260453
PNG
(US10428074, Example 6 | US9527851, 6 | US9527851, ...)
Show SMILES CN([C@@H]1C[C@H]2CN(C[C@H]2C1)C(=O)CO)c1ncnc2[nH]ccc12
PDB

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Jiangsu Hengrui Medicine Co., Ltd.

US Patent


Assay Description
JAK1: In vitro kinase assays described below can be used to determine the activity of a test compound for inhibiting the activity of JAK1 kinase. The...


US Patent US10428074 (2019)


BindingDB Entry DOI: 10.7270/Q26D5WC6
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM260475
PNG
(US10428074, Example 147 | US9527851, 147 | US95278...)
Show SMILES CN([C@H]1C[C@H]2CNC(=O)C[C@H]2C1)c1ncnc2[nH]ccc12
PDB

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Jiangsu Hengrui Medicine Co., Ltd.

US Patent


Assay Description
JAK2: In vitro kinase assays described below can be used to determine the activity of a test compound for inhibiting the activity of JAK2 kinase. The...


US Patent US10428074 (2019)


BindingDB Entry DOI: 10.7270/Q26D5WC6
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM415495
PNG
(US10428074, Example 99)
Show SMILES CN([C@@H]1C[C@H]2CN(C[C@H]2C1)C(=O)Nc1nc(OCC(C)(C)O)ns1)c1ncnc2[nH]ccc12
PDB

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Jiangsu Hengrui Medicine Co., Ltd.

US Patent


Assay Description
JAK2: In vitro kinase assays described below can be used to determine the activity of a test compound for inhibiting the activity of JAK2 kinase. The...


US Patent US10428074 (2019)


BindingDB Entry DOI: 10.7270/Q26D5WC6
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM260485
PNG
(US10428074, Example 69 | US9527851, 69 | US9527851...)
Show SMILES CN([C@H]1C[C@H]2CN(CC#N)C[C@H]2C1)c1ncnc2[nH]ccc12
PDB

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Jiangsu Hengrui Medicine Co., Ltd.

US Patent


Assay Description
JAK1: In vitro kinase assays described below can be used to determine the activity of a test compound for inhibiting the activity of JAK1 kinase. The...


US Patent US10428074 (2019)


BindingDB Entry DOI: 10.7270/Q26D5WC6
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM260469
PNG
(US10428074, Example 34 | US9527851, 34 | US9527851...)
Show SMILES COc1nsc(NC(=O)N2C[C@@H]3C[C@H](C[C@@H]3C2)N(C)c2ncnc3[nH]ccc23)n1
PDB

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Jiangsu Hengrui Medicine Co., Ltd.

US Patent


Assay Description
JAK2: In vitro kinase assays described below can be used to determine the activity of a test compound for inhibiting the activity of JAK2 kinase. The...


US Patent US10428074 (2019)


BindingDB Entry DOI: 10.7270/Q26D5WC6
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM260473
PNG
(US10428074, Example 38 | US9527851, 38 | US9527851...)
Show SMILES COc1nsc(NC(=O)N2CC[C@H]3CC(C[C@H]3C2)N(C)c2ncnc3[nH]ccc23)n1
PDB

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Jiangsu Hengrui Medicine Co., Ltd.

US Patent


Assay Description
JAK2: In vitro kinase assays described below can be used to determine the activity of a test compound for inhibiting the activity of JAK2 kinase. The...


US Patent US10428074 (2019)


BindingDB Entry DOI: 10.7270/Q26D5WC6
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM415473
PNG
((3aR,5S,6aS)?N-(3-(Hydroxymethyl)-1,2,4-thiadiazol...)
Show SMILES CN([C@@H]1C[C@H]2CN(C[C@H]2C1)C(=O)Nc1nc(CO)ns1)c1ncnc2[nH]ccc12
PDB

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Jiangsu Hengrui Medicine Co., Ltd.

US Patent


Assay Description
JAK2: In vitro kinase assays described below can be used to determine the activity of a test compound for inhibiting the activity of JAK2 kinase. The...


US Patent US10428074 (2019)


BindingDB Entry DOI: 10.7270/Q26D5WC6
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM415510
PNG
(US10428074, Example 148)
Show SMILES CN([C@H]1CC2CNC(=O)CC2C1)c1ncnc2[nH]ccc12
PDB

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Jiangsu Hengrui Medicine Co., Ltd.

US Patent


Assay Description
JAK1: In vitro kinase assays described below can be used to determine the activity of a test compound for inhibiting the activity of JAK1 kinase. The...


US Patent US10428074 (2019)


BindingDB Entry DOI: 10.7270/Q26D5WC6
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM260497
PNG
(US10428074, Example 86 | US9527851, 86 | US9527851...)
Show SMILES CN([C@@H]1C[C@H]2CN(C[C@H]2C1)C(=O)Nc1nncs1)c1ncnc2[nH]ccc12
PDB

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Jiangsu Hengrui Medicine Co., Ltd.

US Patent


Assay Description
JAK1: In vitro kinase assays described below can be used to determine the activity of a test compound for inhibiting the activity of JAK1 kinase. The...


US Patent US10428074 (2019)


BindingDB Entry DOI: 10.7270/Q26D5WC6
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))
BDBM260453
PNG
(US10428074, Example 6 | US9527851, 6 | US9527851, ...)
Show SMILES CN([C@@H]1C[C@H]2CN(C[C@H]2C1)C(=O)CO)c1ncnc2[nH]ccc12
PDB

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n/an/a 11n/an/an/an/an/an/a



Jiangsu Hengrui Medicine Co., Ltd.

US Patent


Assay Description
JAK3: In vitro kinase assays described below can be used to determine the activity of a test compound for inhibiting the activity of JAK3 kinase. The...


US Patent US10428074 (2019)


BindingDB Entry DOI: 10.7270/Q26D5WC6
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM260481
PNG
(US10428074, Example 56 | US9527851, 56 | US9527851...)
Show SMILES CN([C@@H]1C[C@H]2CN(CC(F)(F)F)C[C@H]2C1)c1ncnc2[nH]ccc12
PDB

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n/an/a 11n/an/an/an/an/an/a



Jiangsu Hengrui Medicine Co., Ltd.

US Patent


Assay Description
JAK1: In vitro kinase assays described below can be used to determine the activity of a test compound for inhibiting the activity of JAK1 kinase. The...


US Patent US10428074 (2019)


BindingDB Entry DOI: 10.7270/Q26D5WC6
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM260465
PNG
(US10428074, Example 24 | US9527851, 24 | US9527851...)
Show SMILES COC(=O)CN1C[C@@H]2C[C@H](C[C@@H]2C1)N(C)c1ncnc2[nH]ccc12
PDB

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n/an/a 13n/an/an/an/an/an/a



Jiangsu Hengrui Medicine Co., Ltd.

US Patent


Assay Description
JAK1: In vitro kinase assays described below can be used to determine the activity of a test compound for inhibiting the activity of JAK1 kinase. The...


US Patent US10428074 (2019)


BindingDB Entry DOI: 10.7270/Q26D5WC6
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM415507
PNG
(US10428074, Example 128)
Show SMILES CN([C@@H]1C[C@H]2CN(C[C@H]2C1)C(=O)CO)c1ncnc2[nH]cc(F)c12
PDB

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n/an/a 13n/an/an/an/an/an/a



Jiangsu Hengrui Medicine Co., Ltd.

US Patent


Assay Description
JAK1: In vitro kinase assays described below can be used to determine the activity of a test compound for inhibiting the activity of JAK1 kinase. The...


US Patent US10428074 (2019)


BindingDB Entry DOI: 10.7270/Q26D5WC6
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM260478
PNG
(US10428074, Example 125 | US9527851, 125 | US95278...)
Show SMILES CN([C@@H]1C[C@H]2CN(C[C@H]2C1)C(=O)Nc1nc(ns1)C1CC1)c1ncnc2[nH]ccc12
PDB

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n/an/a 14n/an/an/an/an/an/a



Jiangsu Hengrui Medicine Co., Ltd.

US Patent


Assay Description
JAK2: In vitro kinase assays described below can be used to determine the activity of a test compound for inhibiting the activity of JAK2 kinase. The...


US Patent US10428074 (2019)


BindingDB Entry DOI: 10.7270/Q26D5WC6
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM260478
PNG
(US10428074, Example 125 | US9527851, 125 | US95278...)
Show SMILES CN([C@@H]1C[C@H]2CN(C[C@H]2C1)C(=O)Nc1nc(ns1)C1CC1)c1ncnc2[nH]ccc12
PDB

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n/an/a 14n/an/an/an/an/an/a



Jiangsu Hengrui Medicine Co., Ltd.

US Patent


Assay Description
JAK2: In vitro kinase assays described below can be used to determine the activity of a test compound for inhibiting the activity of JAK2 kinase. The...


US Patent US10428074 (2019)


BindingDB Entry DOI: 10.7270/Q26D5WC6
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM260504
PNG
(US10428074, Example 109 | US9527851, 109 | US95278...)
Show SMILES COc1cncc(NC(=O)N2C[C@@H]3C[C@H](C[C@@H]3C2)N(C)c2ncnc3[nH]ccc23)c1
PDB

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n/an/a 15n/an/an/an/an/an/a



Jiangsu Hengrui Medicine Co., Ltd.

US Patent


Assay Description
JAK1: In vitro kinase assays described below can be used to determine the activity of a test compound for inhibiting the activity of JAK1 kinase. The...


US Patent US10428074 (2019)


BindingDB Entry DOI: 10.7270/Q26D5WC6
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM260470
PNG
(US10428074, Example 35 | US9527851, 35)
Show SMILES CN(C1C[C@@H]2CCN(C[C@@H]2C1)C(C)=O)c1ncnc2[nH]ccc12
PDB

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n/an/a 16n/an/an/an/an/an/a



Jiangsu Hengrui Medicine Co., Ltd.

US Patent


Assay Description
JAK2: In vitro kinase assays described below can be used to determine the activity of a test compound for inhibiting the activity of JAK2 kinase. The...


US Patent US10428074 (2019)


BindingDB Entry DOI: 10.7270/Q26D5WC6
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM260463
PNG
(US10428074, Example 22 | US9527851, 22 | US9527851...)
Show SMILES CN([C@@H]1C[C@H]2CN(C[C@H]2C1)C(=O)CCC#N)c1ncnc2[nH]ccc12
PDB

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n/an/a 16n/an/an/an/an/an/a



Jiangsu Hengrui Medicine Co., Ltd.

US Patent


Assay Description
JAK1: In vitro kinase assays described below can be used to determine the activity of a test compound for inhibiting the activity of JAK1 kinase. The...


US Patent US10428074 (2019)


BindingDB Entry DOI: 10.7270/Q26D5WC6
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))
BDBM260515
PNG
(US10428074, Example 129 | US9527851, 129 | US95278...)
Show SMILES CN([C@@H]1C[C@H]2CN(C[C@H]2C1)C(=O)CO)c1ncnc2[nH]c(F)cc12
PDB

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n/an/a 17n/an/an/an/an/an/a



Jiangsu Hengrui Medicine Co., Ltd.

US Patent


Assay Description
JAK3: In vitro kinase assays described below can be used to determine the activity of a test compound for inhibiting the activity of JAK3 kinase. The...


US Patent US10428074 (2019)


BindingDB Entry DOI: 10.7270/Q26D5WC6
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM260462
PNG
(US10428074, Example 21 | US9527851, 21 | US9527851...)
Show SMILES CN([C@@H]1C[C@H]2CN(C[C@H]2C1)C(=O)CNS(C)(=O)=O)c1ncnc2[nH]ccc12
PDB

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n/an/a 17n/an/an/an/an/an/a



Jiangsu Hengrui Medicine Co., Ltd.

US Patent


Assay Description
JAK1: In vitro kinase assays described below can be used to determine the activity of a test compound for inhibiting the activity of JAK1 kinase. The...


US Patent US10428074 (2019)


BindingDB Entry DOI: 10.7270/Q26D5WC6
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM260484
PNG
(US10428074, Example 68 | US9527851, 68 | US9527851...)
Show SMILES CN([C@H]1C[C@H]2CN(CCC#N)C[C@H]2C1)c1ncnc2[nH]ccc12
PDB

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n/an/a 17n/an/an/an/an/an/a



Jiangsu Hengrui Medicine Co., Ltd.

US Patent


Assay Description
JAK1: In vitro kinase assays described below can be used to determine the activity of a test compound for inhibiting the activity of JAK1 kinase. The...


US Patent US10428074 (2019)


BindingDB Entry DOI: 10.7270/Q26D5WC6
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM260484
PNG
(US10428074, Example 68 | US9527851, 68 | US9527851...)
Show SMILES CN([C@H]1C[C@H]2CN(CCC#N)C[C@H]2C1)c1ncnc2[nH]ccc12
PDB

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n/an/a 18n/an/an/an/an/an/a



Jiangsu Hengrui Medicine Co., Ltd.

US Patent


Assay Description
JAK2: In vitro kinase assays described below can be used to determine the activity of a test compound for inhibiting the activity of JAK2 kinase. The...


US Patent US10428074 (2019)


BindingDB Entry DOI: 10.7270/Q26D5WC6
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))
BDBM260485
PNG
(US10428074, Example 69 | US9527851, 69 | US9527851...)
Show SMILES CN([C@H]1C[C@H]2CN(CC#N)C[C@H]2C1)c1ncnc2[nH]ccc12
PDB

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n/an/a 20n/an/an/an/an/an/a



Jiangsu Hengrui Medicine Co., Ltd.

US Patent


Assay Description
JAK3: In vitro kinase assays described below can be used to determine the activity of a test compound for inhibiting the activity of JAK3 kinase. The...


US Patent US10428074 (2019)


BindingDB Entry DOI: 10.7270/Q26D5WC6
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM260464
PNG
(US10428074, Example 23 | US9527851, 23)
Show SMILES CN([C@H]1C[C@H]2CN(C[C@H]2C1)C(=O)CO)c1ncnc2[nH]ccc12
PDB

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n/an/a 21n/an/an/an/an/an/a



Jiangsu Hengrui Medicine Co., Ltd.

US Patent


Assay Description
JAK1: In vitro kinase assays described below can be used to determine the activity of a test compound for inhibiting the activity of JAK1 kinase. The...


US Patent US10428074 (2019)


BindingDB Entry DOI: 10.7270/Q26D5WC6
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM260475
PNG
(US10428074, Example 147 | US9527851, 147 | US95278...)
Show SMILES CN([C@H]1C[C@H]2CNC(=O)C[C@H]2C1)c1ncnc2[nH]ccc12
PDB

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n/an/a 23n/an/an/an/an/an/a



Jiangsu Hengrui Medicine Co., Ltd.

US Patent


Assay Description
JAK2: In vitro kinase assays described below can be used to determine the activity of a test compound for inhibiting the activity of JAK2 kinase. The...


US Patent US10428074 (2019)


BindingDB Entry DOI: 10.7270/Q26D5WC6
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM415500
PNG
(US10428074, Example 113)
Show SMILES COc1nsc(CC(=O)N2C[C@@H]3C[C@H](C[C@@H]3C2)N(C)c2ccnc3[nH]ccc23)n1
PDB

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n/an/a 23n/an/an/an/an/an/a



Jiangsu Hengrui Medicine Co., Ltd.

US Patent


Assay Description
JAK1: In vitro kinase assays described below can be used to determine the activity of a test compound for inhibiting the activity of JAK1 kinase. The...


US Patent US10428074 (2019)


BindingDB Entry DOI: 10.7270/Q26D5WC6
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM415510
PNG
(US10428074, Example 148)
Show SMILES CN([C@H]1CC2CNC(=O)CC2C1)c1ncnc2[nH]ccc12
PDB

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n/an/a 23n/an/an/an/an/an/a



Jiangsu Hengrui Medicine Co., Ltd.

US Patent


Assay Description
JAK2: In vitro kinase assays described below can be used to determine the activity of a test compound for inhibiting the activity of JAK2 kinase. The...


US Patent US10428074 (2019)


BindingDB Entry DOI: 10.7270/Q26D5WC6
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM260521
PNG
(US10428074, Example 150 | US9527851, 150 | US95278...)
Show SMILES CN([C@@H]1C[C@@H]2CCN(C[C@@H]2C1)C(=O)Nc1nncs1)c1ncnc2[nH]ccc12
PDB

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n/an/a 23n/an/an/an/an/an/a



Jiangsu Hengrui Medicine Co., Ltd.

US Patent


Assay Description
JAK2: In vitro kinase assays described below can be used to determine the activity of a test compound for inhibiting the activity of JAK2 kinase. The...


US Patent US10428074 (2019)


BindingDB Entry DOI: 10.7270/Q26D5WC6
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM260471
PNG
(US10428074, Example 36 | US9527851, 36)
Show SMILES COC(=O)N1CC[C@H]2CC(C[C@H]2C1)N(C)c1ncnc2[nH]ccc12
PDB

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n/an/a 25n/an/an/an/an/an/a



Jiangsu Hengrui Medicine Co., Ltd.

US Patent


Assay Description
JAK1: In vitro kinase assays described below can be used to determine the activity of a test compound for inhibiting the activity of JAK1 kinase. The...


US Patent US10428074 (2019)


BindingDB Entry DOI: 10.7270/Q26D5WC6
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM260482
PNG
(US10428074, Example 61 | US9527851, 61 | US9527851...)
Show SMILES CN([C@@H]1C[C@H]2CN(C[C@H]2C1)c1nc(C)no1)c1ncnc2[nH]ccc12
PDB

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n/an/a 25n/an/an/an/an/an/a



Jiangsu Hengrui Medicine Co., Ltd.

US Patent


Assay Description
JAK2: In vitro kinase assays described below can be used to determine the activity of a test compound for inhibiting the activity of JAK2 kinase. The...


US Patent US10428074 (2019)


BindingDB Entry DOI: 10.7270/Q26D5WC6
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM260456
PNG
(US10428074, Example 13 | US9527851, 13 | US9527851...)
Show SMILES CN([C@@H]1C[C@H]2CN(C[C@H]2C1)C(=O)C1CC1)c1ncnc2[nH]ccc12
PDB

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n/an/a 30n/an/an/an/an/an/a



Jiangsu Hengrui Medicine Co., Ltd.

US Patent


Assay Description
JAK1: In vitro kinase assays described below can be used to determine the activity of a test compound for inhibiting the activity of JAK1 kinase. The...


US Patent US10428074 (2019)


BindingDB Entry DOI: 10.7270/Q26D5WC6
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM260467
PNG
(US10428074, Example 27 | US9527851, 27 | US9527851...)
Show SMILES CN([C@@H]1C[C@H]2CN(CCC#N)C[C@H]2C1)c1ncnc2[nH]ccc12
PDB

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n/an/a 30n/an/an/an/an/an/a



Jiangsu Hengrui Medicine Co., Ltd.

US Patent


Assay Description
JAK1: In vitro kinase assays described below can be used to determine the activity of a test compound for inhibiting the activity of JAK1 kinase. The...


US Patent US10428074 (2019)


BindingDB Entry DOI: 10.7270/Q26D5WC6
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM260452
PNG
(US10428074, Example 5 | US9527851, 5 | US9527851, ...)
Show SMILES CN([C@@H]1C[C@H]2CN(C[C@H]2C1)C(=O)OC(C)(C)C)c1ncnc2[nH]ccc12
PDB

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Jiangsu Hengrui Medicine Co., Ltd.

US Patent


Assay Description
JAK1: In vitro kinase assays described below can be used to determine the activity of a test compound for inhibiting the activity of JAK1 kinase. The...


US Patent US10428074 (2019)


BindingDB Entry DOI: 10.7270/Q26D5WC6
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM260453
PNG
(US10428074, Example 6 | US9527851, 6 | US9527851, ...)
Show SMILES CN([C@@H]1C[C@H]2CN(C[C@H]2C1)C(=O)CO)c1ncnc2[nH]ccc12
PDB

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Jiangsu Hengrui Medicine Co., Ltd.

US Patent


Assay Description
JAK1: In vitro kinase assays described below can be used to determine the activity of a test compound for inhibiting the activity of JAK1 kinase. The...


US Patent US10428074 (2019)


BindingDB Entry DOI: 10.7270/Q26D5WC6
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM260477
PNG
(US10428074, Example 121 | US9527851, 121 | US95278...)
Show SMILES CCc1nsc(NC(=O)N2C[C@@H]3C[C@H](C[C@@H]3C2)N(C)c2ncnc3[nH]ccc23)n1
PDB

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n/an/a 31n/an/an/an/an/an/a



Jiangsu Hengrui Medicine Co., Ltd.

US Patent


Assay Description
JAK2: In vitro kinase assays described below can be used to determine the activity of a test compound for inhibiting the activity of JAK2 kinase. The...


US Patent US10428074 (2019)


BindingDB Entry DOI: 10.7270/Q26D5WC6
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM260477
PNG
(US10428074, Example 121 | US9527851, 121 | US95278...)
Show SMILES CCc1nsc(NC(=O)N2C[C@@H]3C[C@H](C[C@@H]3C2)N(C)c2ncnc3[nH]ccc23)n1
PDB

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n/an/a 31n/an/an/an/an/an/a



Jiangsu Hengrui Medicine Co., Ltd.

US Patent


Assay Description
JAK2: In vitro kinase assays described below can be used to determine the activity of a test compound for inhibiting the activity of JAK2 kinase. The...


US Patent US10428074 (2019)


BindingDB Entry DOI: 10.7270/Q26D5WC6
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))
BDBM260475
PNG
(US10428074, Example 147 | US9527851, 147 | US95278...)
Show SMILES CN([C@H]1C[C@H]2CNC(=O)C[C@H]2C1)c1ncnc2[nH]ccc12
PDB

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n/an/a 31n/an/an/an/an/an/a



Jiangsu Hengrui Medicine Co., Ltd.

US Patent


Assay Description
JAK3: In vitro kinase assays described below can be used to determine the activity of a test compound for inhibiting the activity of JAK3 kinase. The...


US Patent US10428074 (2019)


BindingDB Entry DOI: 10.7270/Q26D5WC6
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM260454
PNG
(US10428074, Example 8 | US9527851, 8 | US9527851, ...)
Show SMILES CN([C@@H]1C[C@H]2CN(C[C@H]2C1)C(=O)CC#N)c1ncnc2[nH]ccc12
PDB

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n/an/a 32n/an/an/an/an/an/a



Jiangsu Hengrui Medicine Co., Ltd.

US Patent


Assay Description
JAK1: In vitro kinase assays described below can be used to determine the activity of a test compound for inhibiting the activity of JAK1 kinase. The...


US Patent US10428074 (2019)


BindingDB Entry DOI: 10.7270/Q26D5WC6
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM260481
PNG
(US10428074, Example 56 | US9527851, 56 | US9527851...)
Show SMILES CN([C@@H]1C[C@H]2CN(CC(F)(F)F)C[C@H]2C1)c1ncnc2[nH]ccc12
PDB

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n/an/a 32n/an/an/an/an/an/a



Jiangsu Hengrui Medicine Co., Ltd.

US Patent


Assay Description
JAK2: In vitro kinase assays described below can be used to determine the activity of a test compound for inhibiting the activity of JAK2 kinase. The...


US Patent US10428074 (2019)


BindingDB Entry DOI: 10.7270/Q26D5WC6
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM260455
PNG
(US10428074, Example 11 | US9527851, 11 | US9527851...)
Show SMILES CN([C@@H]1C[C@H]2CN(C[C@H]2C1)C(C)=O)c1ncnc2[nH]ccc12
PDB

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Jiangsu Hengrui Medicine Co., Ltd.

US Patent


Assay Description
JAK1: In vitro kinase assays described below can be used to determine the activity of a test compound for inhibiting the activity of JAK1 kinase. The...


US Patent US10428074 (2019)


BindingDB Entry DOI: 10.7270/Q26D5WC6
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM260474
PNG
(US10428074, Example 39 | US9527851, 39 | US9527851...)
Show SMILES CN(C1C[C@@H]2CCN(C[C@@H]2C1)C(=O)CC#N)c1ncnc2[nH]ccc12
PDB

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Jiangsu Hengrui Medicine Co., Ltd.

US Patent


Assay Description
JAK1: In vitro kinase assays described below can be used to determine the activity of a test compound for inhibiting the activity of JAK1 kinase. The...


US Patent US10428074 (2019)


BindingDB Entry DOI: 10.7270/Q26D5WC6
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM260515
PNG
(US10428074, Example 129 | US9527851, 129 | US95278...)
Show SMILES CN([C@@H]1C[C@H]2CN(C[C@H]2C1)C(=O)CO)c1ncnc2[nH]c(F)cc12
PDB

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Jiangsu Hengrui Medicine Co., Ltd.

US Patent


Assay Description
JAK1: In vitro kinase assays described below can be used to determine the activity of a test compound for inhibiting the activity of JAK1 kinase. The...


US Patent US10428074 (2019)


BindingDB Entry DOI: 10.7270/Q26D5WC6
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM260486
PNG
(US10428074, Example 71 | US9527851, 71 | US9527851...)
Show SMILES C[C@H](O)C(=O)N1C[C@@H]2C[C@@H](C[C@@H]2C1)N(C)c1ncnc2[nH]ccc12
PDB

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Jiangsu Hengrui Medicine Co., Ltd.

US Patent


Assay Description
JAK1: In vitro kinase assays described below can be used to determine the activity of a test compound for inhibiting the activity of JAK1 kinase. The...


US Patent US10428074 (2019)


BindingDB Entry DOI: 10.7270/Q26D5WC6
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))
BDBM260478
PNG
(US10428074, Example 125 | US9527851, 125 | US95278...)
Show SMILES CN([C@@H]1C[C@H]2CN(C[C@H]2C1)C(=O)Nc1nc(ns1)C1CC1)c1ncnc2[nH]ccc12
PDB

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n/an/a 39n/an/an/an/an/an/a



Jiangsu Hengrui Medicine Co., Ltd.

US Patent


Assay Description
JAK3: In vitro kinase assays described below can be used to determine the activity of a test compound for inhibiting the activity of JAK3 kinase. The...


US Patent US10428074 (2019)


BindingDB Entry DOI: 10.7270/Q26D5WC6
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))
BDBM260478
PNG
(US10428074, Example 125 | US9527851, 125 | US95278...)
Show SMILES CN([C@@H]1C[C@H]2CN(C[C@H]2C1)C(=O)Nc1nc(ns1)C1CC1)c1ncnc2[nH]ccc12
PDB

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Jiangsu Hengrui Medicine Co., Ltd.

US Patent


Assay Description
JAK3: In vitro kinase assays described below can be used to determine the activity of a test compound for inhibiting the activity of JAK3 kinase. The...


US Patent US10428074 (2019)


BindingDB Entry DOI: 10.7270/Q26D5WC6
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM260521
PNG
(US10428074, Example 150 | US9527851, 150 | US95278...)
Show SMILES CN([C@@H]1C[C@@H]2CCN(C[C@@H]2C1)C(=O)Nc1nncs1)c1ncnc2[nH]ccc12
PDB

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Jiangsu Hengrui Medicine Co., Ltd.

US Patent


Assay Description
JAK1: In vitro kinase assays described below can be used to determine the activity of a test compound for inhibiting the activity of JAK1 kinase. The...


US Patent US10428074 (2019)


BindingDB Entry DOI: 10.7270/Q26D5WC6
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))
BDBM260473
PNG
(US10428074, Example 38 | US9527851, 38 | US9527851...)
Show SMILES COc1nsc(NC(=O)N2CC[C@H]3CC(C[C@H]3C2)N(C)c2ncnc3[nH]ccc23)n1
PDB

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Jiangsu Hengrui Medicine Co., Ltd.

US Patent


Assay Description
JAK3: In vitro kinase assays described below can be used to determine the activity of a test compound for inhibiting the activity of JAK3 kinase. The...


US Patent US10428074 (2019)


BindingDB Entry DOI: 10.7270/Q26D5WC6
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM415513
PNG
(US10428074, Example 155)
Show SMILES COc1nnc(NC(=O)N2C[C@@H]3C[C@H](C[C@@H]3C2)N(C)c2ncnc3[nH]ccc23)s1
PDB

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Jiangsu Hengrui Medicine Co., Ltd.

US Patent


Assay Description
JAK2: In vitro kinase assays described below can be used to determine the activity of a test compound for inhibiting the activity of JAK2 kinase. The...


US Patent US10428074 (2019)


BindingDB Entry DOI: 10.7270/Q26D5WC6
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM260487
PNG
(US10428074, Example 72 | US9527851, 72 | US9527851...)
Show SMILES C[C@@H](O)C(=O)N1C[C@@H]2C[C@@H](C[C@@H]2C1)N(C)c1ncnc2[nH]ccc12
PDB

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Jiangsu Hengrui Medicine Co., Ltd.

US Patent


Assay Description
JAK1: In vitro kinase assays described below can be used to determine the activity of a test compound for inhibiting the activity of JAK1 kinase. The...


US Patent US10428074 (2019)


BindingDB Entry DOI: 10.7270/Q26D5WC6
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))
BDBM260484
PNG
(US10428074, Example 68 | US9527851, 68 | US9527851...)
Show SMILES CN([C@H]1C[C@H]2CN(CCC#N)C[C@H]2C1)c1ncnc2[nH]ccc12
PDB

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Jiangsu Hengrui Medicine Co., Ltd.

US Patent


Assay Description
JAK3: In vitro kinase assays described below can be used to determine the activity of a test compound for inhibiting the activity of JAK3 kinase. The...


US Patent US10428074 (2019)


BindingDB Entry DOI: 10.7270/Q26D5WC6
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM260500
PNG
(US10428074, Example 94 | US9527851, 94 | US9527851...)
Show SMILES CN([C@@H]1C[C@H]2CN(C[C@H]2C1)C(=O)[C@H](O)C(F)(F)F)c1ncnc2[nH]ccc12
PDB

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n/an/a 45n/an/an/an/an/an/a



Jiangsu Hengrui Medicine Co., Ltd.

US Patent


Assay Description
JAK1: In vitro kinase assays described below can be used to determine the activity of a test compound for inhibiting the activity of JAK1 kinase. The...


US Patent US10428074 (2019)


BindingDB Entry DOI: 10.7270/Q26D5WC6
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM260453
PNG
(US10428074, Example 6 | US9527851, 6 | US9527851, ...)
Show SMILES CN([C@@H]1C[C@H]2CN(C[C@H]2C1)C(=O)CO)c1ncnc2[nH]ccc12
PDB

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Jiangsu Hengrui Medicine Co., Ltd.

US Patent


Assay Description
JAK2: In vitro kinase assays described below can be used to determine the activity of a test compound for inhibiting the activity of JAK2 kinase. The...


US Patent US10428074 (2019)


BindingDB Entry DOI: 10.7270/Q26D5WC6
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM260490
PNG
(US10428074, Example 75 | US9527851, 75 | US9527851...)
Show SMILES CN([C@H]1C[C@H]2CN(C[C@H]2C1)C(=O)CCC#N)c1ncnc2[nH]ccc12
PDB

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Jiangsu Hengrui Medicine Co., Ltd.

US Patent


Assay Description
JAK1: In vitro kinase assays described below can be used to determine the activity of a test compound for inhibiting the activity of JAK1 kinase. The...


US Patent US10428074 (2019)


BindingDB Entry DOI: 10.7270/Q26D5WC6
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM260466
PNG
(US10428074, Example 26 | US9527851, 26 | US9527851...)
Show SMILES CN([C@@H]1C[C@H]2CN(CC#N)C[C@H]2C1)c1ncnc2[nH]ccc12
PDB

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Jiangsu Hengrui Medicine Co., Ltd.

US Patent


Assay Description
JAK1: In vitro kinase assays described below can be used to determine the activity of a test compound for inhibiting the activity of JAK1 kinase. The...


US Patent US10428074 (2019)


BindingDB Entry DOI: 10.7270/Q26D5WC6
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM260488
PNG
(US10428074, Example 73 | US9527851, 73 | US9527851...)
Show SMILES CN([C@H]1C[C@H]2CN(C[C@H]2C1)C(=O)Nc1nncs1)c1ncnc2[nH]ccc12
PDB

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Jiangsu Hengrui Medicine Co., Ltd.

US Patent


Assay Description
JAK2: In vitro kinase assays described below can be used to determine the activity of a test compound for inhibiting the activity of JAK2 kinase. The...


US Patent US10428074 (2019)


BindingDB Entry DOI: 10.7270/Q26D5WC6
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM260510
PNG
(US10428074, Example 119 | US9527851, 119 | US95278...)
Show SMILES CN([C@@H]1C[C@H]2CN(C[C@H]2C1)C(=O)Nc1cc(C)ns1)c1ncnc2[nH]ccc12
PDB

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Jiangsu Hengrui Medicine Co., Ltd.

US Patent


Assay Description
JAK1: In vitro kinase assays described below can be used to determine the activity of a test compound for inhibiting the activity of JAK1 kinase. The...


US Patent US10428074 (2019)


BindingDB Entry DOI: 10.7270/Q26D5WC6
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM260461
PNG
(US10428074, Example 19 | US9527851, 19 | US9527851...)
Show SMILES C[C@@H](O)C(=O)N1C[C@@H]2C[C@H](C[C@@H]2C1)N(C)c1ncnc2[nH]ccc12
PDB

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n/an/a 48n/an/an/an/an/an/a



Jiangsu Hengrui Medicine Co., Ltd.

US Patent


Assay Description
JAK1: In vitro kinase assays described below can be used to determine the activity of a test compound for inhibiting the activity of JAK1 kinase. The...


US Patent US10428074 (2019)


BindingDB Entry DOI: 10.7270/Q26D5WC6
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM260493
PNG
(US10428074, Example 82 | US9527851, 82 | US9527851...)
Show SMILES CC(C#N)C(=O)N1C[C@@H]2C[C@H](C[C@@H]2C1)N(C)c1ncnc2[nH]ccc12
PDB

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n/an/a 49n/an/an/an/an/an/a



Jiangsu Hengrui Medicine Co., Ltd.

US Patent


Assay Description
JAK1: In vitro kinase assays described below can be used to determine the activity of a test compound for inhibiting the activity of JAK1 kinase. The...


US Patent US10428074 (2019)


BindingDB Entry DOI: 10.7270/Q26D5WC6
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM260460
PNG
(US10428074, Example 18 | US9527851, 18 | US9527851...)
Show SMILES COCC(=O)N1C[C@@H]2C[C@H](C[C@@H]2C1)N(C)c1ncnc2[nH]ccc12
PDB

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Jiangsu Hengrui Medicine Co., Ltd.

US Patent


Assay Description
JAK1: In vitro kinase assays described below can be used to determine the activity of a test compound for inhibiting the activity of JAK1 kinase. The...


US Patent US10428074 (2019)


BindingDB Entry DOI: 10.7270/Q26D5WC6
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM260494
PNG
(US10428074, Example 83 | US9527851, 83 | US9527851...)
Show SMILES CN([C@@H]1C[C@H]2CN(C[C@H]2C1)C(=O)C(C)(C)O)c1ncnc2[nH]ccc12
PDB

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Jiangsu Hengrui Medicine Co., Ltd.

US Patent


Assay Description
JAK1: In vitro kinase assays described below can be used to determine the activity of a test compound for inhibiting the activity of JAK1 kinase. The...


US Patent US10428074 (2019)


BindingDB Entry DOI: 10.7270/Q26D5WC6
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM260472
PNG
(US10428074, Example 37 | US9527851, 37 | US9527851...)
Show SMILES CN(C1C[C@@H]2CCN(C[C@@H]2C1)C(=O)CO)c1ncnc2[nH]ccc12
PDB

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Jiangsu Hengrui Medicine Co., Ltd.

US Patent


Assay Description
JAK1: In vitro kinase assays described below can be used to determine the activity of a test compound for inhibiting the activity of JAK1 kinase. The...


US Patent US10428074 (2019)


BindingDB Entry DOI: 10.7270/Q26D5WC6
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM202344
PNG
(US10428074, Example 65 | US9527851, example 65)
Show SMILES CN([C@@H]1C[C@H]2CN(C[C@H]2C1)c1nc(C)ns1)c1ncnc2[nH]ccc12
PDB

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Jiangsu Hengrui Medicine Co., Ltd.

US Patent


Assay Description
JAK1: In vitro kinase assays described below can be used to determine the activity of a test compound for inhibiting the activity of JAK1 kinase. The...


US Patent US10428074 (2019)


BindingDB Entry DOI: 10.7270/Q26D5WC6
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM260497
PNG
(US10428074, Example 86 | US9527851, 86 | US9527851...)
Show SMILES CN([C@@H]1C[C@H]2CN(C[C@H]2C1)C(=O)Nc1nncs1)c1ncnc2[nH]ccc12
PDB

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n/an/a 52n/an/an/an/an/an/a



Jiangsu Hengrui Medicine Co., Ltd.

US Patent


Assay Description
JAK2: In vitro kinase assays described below can be used to determine the activity of a test compound for inhibiting the activity of JAK2 kinase. The...


US Patent US10428074 (2019)


BindingDB Entry DOI: 10.7270/Q26D5WC6
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM260463
PNG
(US10428074, Example 22 | US9527851, 22 | US9527851...)
Show SMILES CN([C@@H]1C[C@H]2CN(C[C@H]2C1)C(=O)CCC#N)c1ncnc2[nH]ccc12
PDB

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n/an/a 54n/an/an/an/an/an/a



Jiangsu Hengrui Medicine Co., Ltd.

US Patent


Assay Description
JAK2: In vitro kinase assays described below can be used to determine the activity of a test compound for inhibiting the activity of JAK2 kinase. The...


US Patent US10428074 (2019)


BindingDB Entry DOI: 10.7270/Q26D5WC6
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM260489
PNG
(US10428074, Example 74 | US9527851, 74 | US9527851...)
Show SMILES COc1nsc(NC(=O)N2C[C@@H]3C[C@@H](C[C@@H]3C2)N(C)c2ncnc3[nH]ccc23)n1
PDB

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n/an/a 56n/an/an/an/an/an/a



Jiangsu Hengrui Medicine Co., Ltd.

US Patent


Assay Description
JAK2: In vitro kinase assays described below can be used to determine the activity of a test compound for inhibiting the activity of JAK2 kinase. The...


US Patent US10428074 (2019)


BindingDB Entry DOI: 10.7270/Q26D5WC6
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM260517
PNG
(US10428074, Example 134 | US9527851, 134 | US95278...)
Show SMILES COC(=O)CN1C[C@H]2[C@H](CN(C)c3ncnc4[nH]ccc34)[C@H]2C1
PDB

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n/an/a 60n/an/an/an/an/an/a



Jiangsu Hengrui Medicine Co., Ltd.

US Patent


Assay Description
JAK2: In vitro kinase assays described below can be used to determine the activity of a test compound for inhibiting the activity of JAK2 kinase. The...


US Patent US10428074 (2019)


BindingDB Entry DOI: 10.7270/Q26D5WC6
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))
BDBM260454
PNG
(US10428074, Example 8 | US9527851, 8 | US9527851, ...)
Show SMILES CN([C@@H]1C[C@H]2CN(C[C@H]2C1)C(=O)CC#N)c1ncnc2[nH]ccc12
PDB

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n/an/a 67n/an/an/an/an/an/a



Jiangsu Hengrui Medicine Co., Ltd.

US Patent


Assay Description
JAK3: In vitro kinase assays described below can be used to determine the activity of a test compound for inhibiting the activity of JAK3 kinase. The...


US Patent US10428074 (2019)


BindingDB Entry DOI: 10.7270/Q26D5WC6
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))
BDBM260495
PNG
(US10428074, Example 84 | US9527851, 84 | US9527851...)
Show SMILES CCC(=O)N1C[C@@H]2C[C@H](C[C@@H]2C1)N(C)c1ncnc2[nH]ccc12
PDB

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n/an/a 70n/an/an/an/an/an/a



Jiangsu Hengrui Medicine Co., Ltd.

US Patent


Assay Description
JAK3: In vitro kinase assays described below can be used to determine the activity of a test compound for inhibiting the activity of JAK3 kinase. The...


US Patent US10428074 (2019)


BindingDB Entry DOI: 10.7270/Q26D5WC6
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM260499
PNG
(US10428074, Example 93 | US9527851, 93 | US9527851...)
Show SMILES CC[C@H](O)C(=O)N1C[C@@H]2C[C@H](C[C@@H]2C1)N(C)c1ncnc2[nH]ccc12
PDB

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n/an/a 70n/an/an/an/an/an/a



Jiangsu Hengrui Medicine Co., Ltd.

US Patent


Assay Description
JAK1: In vitro kinase assays described below can be used to determine the activity of a test compound for inhibiting the activity of JAK1 kinase. The...


US Patent US10428074 (2019)


BindingDB Entry DOI: 10.7270/Q26D5WC6
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))
BDBM415510
PNG
(US10428074, Example 148)
Show SMILES CN([C@H]1CC2CNC(=O)CC2C1)c1ncnc2[nH]ccc12
PDB

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n/an/a 71n/an/an/an/an/an/a



Jiangsu Hengrui Medicine Co., Ltd.

US Patent


Assay Description
JAK3: In vitro kinase assays described below can be used to determine the activity of a test compound for inhibiting the activity of JAK3 kinase. The...


US Patent US10428074 (2019)


BindingDB Entry DOI: 10.7270/Q26D5WC6
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))
BDBM260475
PNG
(US10428074, Example 147 | US9527851, 147 | US95278...)
Show SMILES CN([C@H]1C[C@H]2CNC(=O)C[C@H]2C1)c1ncnc2[nH]ccc12
PDB

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n/an/a 71n/an/an/an/an/an/a



Jiangsu Hengrui Medicine Co., Ltd.

US Patent


Assay Description
JAK3: In vitro kinase assays described below can be used to determine the activity of a test compound for inhibiting the activity of JAK3 kinase. The...


US Patent US10428074 (2019)


BindingDB Entry DOI: 10.7270/Q26D5WC6
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM260472
PNG
(US10428074, Example 37 | US9527851, 37 | US9527851...)
Show SMILES CN(C1C[C@@H]2CCN(C[C@@H]2C1)C(=O)CO)c1ncnc2[nH]ccc12
PDB

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Jiangsu Hengrui Medicine Co., Ltd.

US Patent


Assay Description
JAK2: In vitro kinase assays described below can be used to determine the activity of a test compound for inhibiting the activity of JAK2 kinase. The...


US Patent US10428074 (2019)


BindingDB Entry DOI: 10.7270/Q26D5WC6
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM260495
PNG
(US10428074, Example 84 | US9527851, 84 | US9527851...)
Show SMILES CCC(=O)N1C[C@@H]2C[C@H](C[C@@H]2C1)N(C)c1ncnc2[nH]ccc12
PDB

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Jiangsu Hengrui Medicine Co., Ltd.

US Patent


Assay Description
JAK1: In vitro kinase assays described below can be used to determine the activity of a test compound for inhibiting the activity of JAK1 kinase. The...


US Patent US10428074 (2019)


BindingDB Entry DOI: 10.7270/Q26D5WC6
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))
BDBM260481
PNG
(US10428074, Example 56 | US9527851, 56 | US9527851...)
Show SMILES CN([C@@H]1C[C@H]2CN(CC(F)(F)F)C[C@H]2C1)c1ncnc2[nH]ccc12
PDB

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n/an/a 75n/an/an/an/an/an/a



Jiangsu Hengrui Medicine Co., Ltd.

US Patent


Assay Description
JAK3: In vitro kinase assays described below can be used to determine the activity of a test compound for inhibiting the activity of JAK3 kinase. The...


US Patent US10428074 (2019)


BindingDB Entry DOI: 10.7270/Q26D5WC6
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM260471
PNG
(US10428074, Example 36 | US9527851, 36)
Show SMILES COC(=O)N1CC[C@H]2CC(C[C@H]2C1)N(C)c1ncnc2[nH]ccc12
PDB

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Jiangsu Hengrui Medicine Co., Ltd.

US Patent


Assay Description
JAK2: In vitro kinase assays described below can be used to determine the activity of a test compound for inhibiting the activity of JAK2 kinase. The...


US Patent US10428074 (2019)


BindingDB Entry DOI: 10.7270/Q26D5WC6
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM260488
PNG
(US10428074, Example 73 | US9527851, 73 | US9527851...)
Show SMILES CN([C@H]1C[C@H]2CN(C[C@H]2C1)C(=O)Nc1nncs1)c1ncnc2[nH]ccc12
PDB

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Jiangsu Hengrui Medicine Co., Ltd.

US Patent


Assay Description
JAK1: In vitro kinase assays described below can be used to determine the activity of a test compound for inhibiting the activity of JAK1 kinase. The...


US Patent US10428074 (2019)


BindingDB Entry DOI: 10.7270/Q26D5WC6
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM260465
PNG
(US10428074, Example 24 | US9527851, 24 | US9527851...)
Show SMILES COC(=O)CN1C[C@@H]2C[C@H](C[C@@H]2C1)N(C)c1ncnc2[nH]ccc12
PDB

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Jiangsu Hengrui Medicine Co., Ltd.

US Patent


Assay Description
JAK2: In vitro kinase assays described below can be used to determine the activity of a test compound for inhibiting the activity of JAK2 kinase. The...


US Patent US10428074 (2019)


BindingDB Entry DOI: 10.7270/Q26D5WC6
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM260458
PNG
(US10428074, Example 15 | US9527851, 15 | US9527851...)
Show SMILES CN([C@@H]1C[C@H]2CN(C[C@H]2C1)S(=O)(=O)C1CC1)c1ncnc2[nH]ccc12
PDB

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Jiangsu Hengrui Medicine Co., Ltd.

US Patent


Assay Description
JAK1: In vitro kinase assays described below can be used to determine the activity of a test compound for inhibiting the activity of JAK1 kinase. The...


US Patent US10428074 (2019)


BindingDB Entry DOI: 10.7270/Q26D5WC6
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM260496
PNG
(US10428074, Example 85 | US9527851, 85 | US9527851...)
Show SMILES CN([C@@H]1C[C@H]2CN(C[C@H]2C1)C(=O)Cc1nn[nH]n1)c1ncnc2[nH]ccc12
PDB

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n/an/a 80n/an/an/an/an/an/a



Jiangsu Hengrui Medicine Co., Ltd.

US Patent


Assay Description
JAK1: In vitro kinase assays described below can be used to determine the activity of a test compound for inhibiting the activity of JAK1 kinase. The...


US Patent US10428074 (2019)


BindingDB Entry DOI: 10.7270/Q26D5WC6
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM260476
PNG
(US10428074, Example 41 | US9527851, 41 | US9527851...)
Show SMILES CN([C@@H]1C[C@H]2CNC(=O)C[C@H]2C1)c1ncnc2[nH]ccc12
PDB

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n/an/a 80n/an/an/an/an/an/a



Jiangsu Hengrui Medicine Co., Ltd.

US Patent


Assay Description
JAK1: In vitro kinase assays described below can be used to determine the activity of a test compound for inhibiting the activity of JAK1 kinase. The...


US Patent US10428074 (2019)


BindingDB Entry DOI: 10.7270/Q26D5WC6
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))
BDBM260516
PNG
(US10428074, Example 133 | US9527851, 133 | US95278...)
Show SMILES CN(C[C@H]1[C@@H]2CN(C[C@H]12)C(=O)OC(C)(C)C)c1ncnc2[nH]ccc12
PDB

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n/an/a 90n/an/an/an/an/an/a



Jiangsu Hengrui Medicine Co., Ltd.

US Patent


Assay Description
JAK3: In vitro kinase assays described below can be used to determine the activity of a test compound for inhibiting the activity of JAK3 kinase. The...


US Patent US10428074 (2019)


BindingDB Entry DOI: 10.7270/Q26D5WC6
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))
BDBM260468
PNG
(US10428074, Example 31 | US9527851, 31 | US9527851...)
Show SMILES CN(C[C@H]1[C@@H]2CN(C[C@H]12)C(=O)CO)c1ncnc2[nH]ccc12
PDB

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n/an/a 93n/an/an/an/an/an/a



Jiangsu Hengrui Medicine Co., Ltd.

US Patent


Assay Description
JAK3: In vitro kinase assays described below can be used to determine the activity of a test compound for inhibiting the activity of JAK3 kinase. The...


US Patent US10428074 (2019)


BindingDB Entry DOI: 10.7270/Q26D5WC6
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM260509
PNG
(US10428074, Example 117 | US9527851, 117 | US95278...)
Show SMILES CN([C@@H]1C[C@H]2CN(C[C@H]2C1)C(=O)Nc1ncc(C)s1)c1ncnc2[nH]ccc12
PDB

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n/an/a 95n/an/an/an/an/an/a



Jiangsu Hengrui Medicine Co., Ltd.

US Patent


Assay Description
JAK1: In vitro kinase assays described below can be used to determine the activity of a test compound for inhibiting the activity of JAK1 kinase. The...


US Patent US10428074 (2019)


BindingDB Entry DOI: 10.7270/Q26D5WC6
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM260506
PNG
(US10428074, Example 112 | US9527851, 112)
Show SMILES CN([C@@H]1C[C@H]2CN(C[C@H]2C1)C(=O)CO)c1ccnc2[nH]ccc12
PDB

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n/an/a 96n/an/an/an/an/an/a



Jiangsu Hengrui Medicine Co., Ltd.

US Patent


Assay Description
JAK1: In vitro kinase assays described below can be used to determine the activity of a test compound for inhibiting the activity of JAK1 kinase. The...


US Patent US10428074 (2019)


BindingDB Entry DOI: 10.7270/Q26D5WC6
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM260505
PNG
(US10428074, Example 111 | US9527851, 111 | US95278...)
Show SMILES CN([C@@H]1C[C@H]2CN(C[C@H]2C1)C(=O)OCC(F)(F)F)c1ncnc2[nH]ccc12
PDB

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n/an/a 96n/an/an/an/an/an/a



Jiangsu Hengrui Medicine Co., Ltd.

US Patent


Assay Description
JAK1: In vitro kinase assays described below can be used to determine the activity of a test compound for inhibiting the activity of JAK1 kinase. The...


US Patent US10428074 (2019)


BindingDB Entry DOI: 10.7270/Q26D5WC6
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM260475
PNG
(US10428074, Example 147 | US9527851, 147 | US95278...)
Show SMILES CN([C@H]1C[C@H]2CNC(=O)C[C@H]2C1)c1ncnc2[nH]ccc12
PDB

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n/an/a 98n/an/an/an/an/an/a



Jiangsu Hengrui Medicine Co., Ltd.

US Patent


Assay Description
JAK1: In vitro kinase assays described below can be used to determine the activity of a test compound for inhibiting the activity of JAK1 kinase. The...


US Patent US10428074 (2019)


BindingDB Entry DOI: 10.7270/Q26D5WC6
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM415474
PNG
(US10428074, Example 51)
Show SMILES CN([C@@H]1C[C@H]2CN(C[C@H]2C1)S(C)(=O)=O)c1ncnc2[nH]ccc12
PDB

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Jiangsu Hengrui Medicine Co., Ltd.

US Patent


Assay Description
JAK1: In vitro kinase assays described below can be used to determine the activity of a test compound for inhibiting the activity of JAK1 kinase. The...


US Patent US10428074 (2019)


BindingDB Entry DOI: 10.7270/Q26D5WC6
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))
BDBM260505
PNG
(US10428074, Example 111 | US9527851, 111 | US95278...)
Show SMILES CN([C@@H]1C[C@H]2CN(C[C@H]2C1)C(=O)OCC(F)(F)F)c1ncnc2[nH]ccc12
PDB

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n/an/a 101n/an/an/an/an/an/a



Jiangsu Hengrui Medicine Co., Ltd.

US Patent


Assay Description
JAK3: In vitro kinase assays described below can be used to determine the activity of a test compound for inhibiting the activity of JAK3 kinase. The...


US Patent US10428074 (2019)


BindingDB Entry DOI: 10.7270/Q26D5WC6
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM260522
PNG
(US10428074, Example 151 | US9527851, 151 | US95278...)
Show SMILES CC(C)C(=O)N1CC[C@H]2C[C@H](C[C@H]2C1)N(C)c1ncnc2[nH]ccc12
PDB

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n/an/a 106n/an/an/an/an/an/a



Jiangsu Hengrui Medicine Co., Ltd.

US Patent


Assay Description
JAK1: In vitro kinase assays described below can be used to determine the activity of a test compound for inhibiting the activity of JAK1 kinase. The...


US Patent US10428074 (2019)


BindingDB Entry DOI: 10.7270/Q26D5WC6
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM260503
PNG
(US10428074, Example 104 | US9527851, 104 | US95278...)
Show SMILES CN([C@@H]1C[C@H]2CN(C[C@H]2C1)C(=O)Nc1ccn(C)n1)c1ncnc2[nH]ccc12
PDB

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n/an/a 109n/an/an/an/an/an/a



Jiangsu Hengrui Medicine Co., Ltd.

US Patent


Assay Description
JAK1: In vitro kinase assays described below can be used to determine the activity of a test compound for inhibiting the activity of JAK1 kinase. The...


US Patent US10428074 (2019)


BindingDB Entry DOI: 10.7270/Q26D5WC6
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))
BDBM260501
PNG
(US10428074, Example 97 | US9527851, 97 | US9527851...)
Show SMILES CN([C@@H]1C[C@H]2CN(C[C@H]2C1)C(=O)C(O)C(F)(F)F)c1ncnc2[nH]ccc12
PDB

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n/an/a 110n/an/an/an/an/an/a



Jiangsu Hengrui Medicine Co., Ltd.

US Patent


Assay Description
JAK3: In vitro kinase assays described below can be used to determine the activity of a test compound for inhibiting the activity of JAK3 kinase. The...


US Patent US10428074 (2019)


BindingDB Entry DOI: 10.7270/Q26D5WC6
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))
BDBM415495
PNG
(US10428074, Example 99)
Show SMILES CN([C@@H]1C[C@H]2CN(C[C@H]2C1)C(=O)Nc1nc(OCC(C)(C)O)ns1)c1ncnc2[nH]ccc12
PDB

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n/an/a 110n/an/an/an/an/an/a



Jiangsu Hengrui Medicine Co., Ltd.

US Patent


Assay Description
JAK3: In vitro kinase assays described below can be used to determine the activity of a test compound for inhibiting the activity of JAK3 kinase. The...


US Patent US10428074 (2019)


BindingDB Entry DOI: 10.7270/Q26D5WC6
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM260474
PNG
(US10428074, Example 39 | US9527851, 39 | US9527851...)
Show SMILES CN(C1C[C@@H]2CCN(C[C@@H]2C1)C(=O)CC#N)c1ncnc2[nH]ccc12
PDB

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n/an/a 113n/an/an/an/an/an/a



Jiangsu Hengrui Medicine Co., Ltd.

US Patent


Assay Description
JAK2: In vitro kinase assays described below can be used to determine the activity of a test compound for inhibiting the activity of JAK2 kinase. The...


US Patent US10428074 (2019)


BindingDB Entry DOI: 10.7270/Q26D5WC6
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM260492
PNG
(US10428074, Example 81 | US9527851, 81 | US9527851...)
Show SMILES CN([C@@H]1C[C@H]2CN(C[C@H]2C1)C(=O)[C@H](O)c1ccccc1)c1ncnc2[nH]ccc12
PDB

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n/an/a 113n/an/an/an/an/an/a



Jiangsu Hengrui Medicine Co., Ltd.

US Patent


Assay Description
JAK1: In vitro kinase assays described below can be used to determine the activity of a test compound for inhibiting the activity of JAK1 kinase. The...


US Patent US10428074 (2019)


BindingDB Entry DOI: 10.7270/Q26D5WC6
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM260512
PNG
(US10428074, Example 124 | US9527851, 124 | US95278...)
Show SMILES CN([C@@H]1C[C@H]2CN(C[C@H]2C1)C(=O)Nc1cnc(C)s1)c1ncnc2[nH]ccc12
PDB

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n/an/a 119n/an/an/an/an/an/a



Jiangsu Hengrui Medicine Co., Ltd.

US Patent


Assay Description
JAK1: In vitro kinase assays described below can be used to determine the activity of a test compound for inhibiting the activity of JAK1 kinase. The...


US Patent US10428074 (2019)


BindingDB Entry DOI: 10.7270/Q26D5WC6
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM260522
PNG
(US10428074, Example 151 | US9527851, 151 | US95278...)
Show SMILES CC(C)C(=O)N1CC[C@H]2C[C@H](C[C@H]2C1)N(C)c1ncnc2[nH]ccc12
PDB

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n/an/a 127n/an/an/an/an/an/a



Jiangsu Hengrui Medicine Co., Ltd.

US Patent


Assay Description
JAK2: In vitro kinase assays described below can be used to determine the activity of a test compound for inhibiting the activity of JAK2 kinase. The...


US Patent US10428074 (2019)


BindingDB Entry DOI: 10.7270/Q26D5WC6
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM260491
PNG
(US10428074, Example 80 | US9527851, 80 | US9527851...)
Show SMILES CNC(=O)N1C[C@@H]2C[C@H](C[C@@H]2C1)N(C)c1ncnc2[nH]ccc12
PDB

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n/an/a 127n/an/an/an/an/an/a



Jiangsu Hengrui Medicine Co., Ltd.

US Patent


Assay Description
JAK1: In vitro kinase assays described below can be used to determine the activity of a test compound for inhibiting the activity of JAK1 kinase. The...


US Patent US10428074 (2019)


BindingDB Entry DOI: 10.7270/Q26D5WC6
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM260482
PNG
(US10428074, Example 61 | US9527851, 61 | US9527851...)
Show SMILES CN([C@@H]1C[C@H]2CN(C[C@H]2C1)c1nc(C)no1)c1ncnc2[nH]ccc12
PDB

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n/an/a 128n/an/an/an/an/an/a



Jiangsu Hengrui Medicine Co., Ltd.

US Patent


Assay Description
JAK1: In vitro kinase assays described below can be used to determine the activity of a test compound for inhibiting the activity of JAK1 kinase. The...


US Patent US10428074 (2019)


BindingDB Entry DOI: 10.7270/Q26D5WC6
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM260498
PNG
(US10428074, Example 92 | US9527851, 92 | US9527851...)
Show SMILES CN([C@@H]1C[C@H]2CN(C[C@H]2C1)C(=O)[C@H](O)CO)c1ncnc2[nH]ccc12
PDB

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n/an/a 131n/an/an/an/an/an/a



Jiangsu Hengrui Medicine Co., Ltd.

US Patent


Assay Description
JAK1: In vitro kinase assays described below can be used to determine the activity of a test compound for inhibiting the activity of JAK1 kinase. The...


US Patent US10428074 (2019)


BindingDB Entry DOI: 10.7270/Q26D5WC6
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM260508
PNG
(US10428074, Example 114 | US9527851, 114 | US95278...)
Show SMILES CN([C@@H]1C[C@H]2CN(C[C@H]2C1)C(=O)Nc1nc(C)ns1)c1ccnc2[nH]ccc12
PDB

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n/an/a 140n/an/an/an/an/an/a



Jiangsu Hengrui Medicine Co., Ltd.

US Patent


Assay Description
JAK2: In vitro kinase assays described below can be used to determine the activity of a test compound for inhibiting the activity of JAK2 kinase. The...


US Patent US10428074 (2019)


BindingDB Entry DOI: 10.7270/Q26D5WC6
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM260505
PNG
(US10428074, Example 111 | US9527851, 111 | US95278...)
Show SMILES CN([C@@H]1C[C@H]2CN(C[C@H]2C1)C(=O)OCC(F)(F)F)c1ncnc2[nH]ccc12
PDB

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n/an/a 146n/an/an/an/an/an/a



Jiangsu Hengrui Medicine Co., Ltd.

US Patent


Assay Description
JAK2: In vitro kinase assays described below can be used to determine the activity of a test compound for inhibiting the activity of JAK2 kinase. The...


US Patent US10428074 (2019)


BindingDB Entry DOI: 10.7270/Q26D5WC6
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))
BDBM260521
PNG
(US10428074, Example 150 | US9527851, 150 | US95278...)
Show SMILES CN([C@@H]1C[C@@H]2CCN(C[C@@H]2C1)C(=O)Nc1nncs1)c1ncnc2[nH]ccc12
PDB

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n/an/a 148n/an/an/an/an/an/a



Jiangsu Hengrui Medicine Co., Ltd.

US Patent


Assay Description
JAK3: In vitro kinase assays described below can be used to determine the activity of a test compound for inhibiting the activity of JAK3 kinase. The...


US Patent US10428074 (2019)


BindingDB Entry DOI: 10.7270/Q26D5WC6
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM260490
PNG
(US10428074, Example 75 | US9527851, 75 | US9527851...)
Show SMILES CN([C@H]1C[C@H]2CN(C[C@H]2C1)C(=O)CCC#N)c1ncnc2[nH]ccc12
PDB

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n/an/a 156n/an/an/an/an/an/a



Jiangsu Hengrui Medicine Co., Ltd.

US Patent


Assay Description
JAK2: In vitro kinase assays described below can be used to determine the activity of a test compound for inhibiting the activity of JAK2 kinase. The...


US Patent US10428074 (2019)


BindingDB Entry DOI: 10.7270/Q26D5WC6
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))
BDBM260517
PNG
(US10428074, Example 134 | US9527851, 134 | US95278...)
Show SMILES COC(=O)CN1C[C@H]2[C@H](CN(C)c3ncnc4[nH]ccc34)[C@H]2C1
PDB

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n/an/a 164n/an/an/an/an/an/a



Jiangsu Hengrui Medicine Co., Ltd.

US Patent


Assay Description
JAK3: In vitro kinase assays described below can be used to determine the activity of a test compound for inhibiting the activity of JAK3 kinase. The...


US Patent US10428074 (2019)


BindingDB Entry DOI: 10.7270/Q26D5WC6
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM415514
PNG
(US10428074, Example 156)
Show SMILES CN([C@@H]1C[C@H]2CN(C[C@H]2C1)C(=O)Nc1nc(O)ns1)c1ncnc2[nH]ccc12
PDB

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n/an/a 171n/an/an/an/an/an/a



Jiangsu Hengrui Medicine Co., Ltd.

US Patent


Assay Description
JAK1: In vitro kinase assays described below can be used to determine the activity of a test compound for inhibiting the activity of JAK1 kinase. The...


US Patent US10428074 (2019)


BindingDB Entry DOI: 10.7270/Q26D5WC6
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM415500
PNG
(US10428074, Example 113)
Show SMILES COc1nsc(CC(=O)N2C[C@@H]3C[C@H](C[C@@H]3C2)N(C)c2ccnc3[nH]ccc23)n1
PDB

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n/an/a 178n/an/an/an/an/an/a



Jiangsu Hengrui Medicine Co., Ltd.

US Patent


Assay Description
JAK2: In vitro kinase assays described below can be used to determine the activity of a test compound for inhibiting the activity of JAK2 kinase. The...


US Patent US10428074 (2019)


BindingDB Entry DOI: 10.7270/Q26D5WC6
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM202344
PNG
(US10428074, Example 65 | US9527851, example 65)
Show SMILES CN([C@@H]1C[C@H]2CN(C[C@H]2C1)c1nc(C)ns1)c1ncnc2[nH]ccc12
PDB

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n/an/a 179n/an/an/an/an/an/a



Jiangsu Hengrui Medicine Co., Ltd.

US Patent


Assay Description
JAK2: In vitro kinase assays described below can be used to determine the activity of a test compound for inhibiting the activity of JAK2 kinase. The...


US Patent US10428074 (2019)


BindingDB Entry DOI: 10.7270/Q26D5WC6
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))
BDBM260488
PNG
(US10428074, Example 73 | US9527851, 73 | US9527851...)
Show SMILES CN([C@H]1C[C@H]2CN(C[C@H]2C1)C(=O)Nc1nncs1)c1ncnc2[nH]ccc12
PDB

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n/an/a 191n/an/an/an/an/an/a



Jiangsu Hengrui Medicine Co., Ltd.

US Patent


Assay Description
JAK3: In vitro kinase assays described below can be used to determine the activity of a test compound for inhibiting the activity of JAK3 kinase. The...


US Patent US10428074 (2019)


BindingDB Entry DOI: 10.7270/Q26D5WC6
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM415507
PNG
(US10428074, Example 128)
Show SMILES CN([C@@H]1C[C@H]2CN(C[C@H]2C1)C(=O)CO)c1ncnc2[nH]cc(F)c12
PDB

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n/an/a 196n/an/an/an/an/an/a



Jiangsu Hengrui Medicine Co., Ltd.

US Patent


Assay Description
JAK2: In vitro kinase assays described below can be used to determine the activity of a test compound for inhibiting the activity of JAK2 kinase. The...


US Patent US10428074 (2019)


BindingDB Entry DOI: 10.7270/Q26D5WC6
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))
BDBM415473
PNG
((3aR,5S,6aS)?N-(3-(Hydroxymethyl)-1,2,4-thiadiazol...)
Show SMILES CN([C@@H]1C[C@H]2CN(C[C@H]2C1)C(=O)Nc1nc(CO)ns1)c1ncnc2[nH]ccc12
PDB

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n/an/a 201n/an/an/an/an/an/a



Jiangsu Hengrui Medicine Co., Ltd.

US Patent


Assay Description
JAK3: In vitro kinase assays described below can be used to determine the activity of a test compound for inhibiting the activity of JAK3 kinase. The...


US Patent US10428074 (2019)


BindingDB Entry DOI: 10.7270/Q26D5WC6
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))
BDBM260522
PNG
(US10428074, Example 151 | US9527851, 151 | US95278...)
Show SMILES CC(C)C(=O)N1CC[C@H]2C[C@H](C[C@H]2C1)N(C)c1ncnc2[nH]ccc12
PDB

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n/an/a 203n/an/an/an/an/an/a



Jiangsu Hengrui Medicine Co., Ltd.

US Patent


Assay Description
JAK3: In vitro kinase assays described below can be used to determine the activity of a test compound for inhibiting the activity of JAK3 kinase. The...


US Patent US10428074 (2019)


BindingDB Entry DOI: 10.7270/Q26D5WC6
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM260498
PNG
(US10428074, Example 92 | US9527851, 92 | US9527851...)
Show SMILES CN([C@@H]1C[C@H]2CN(C[C@H]2C1)C(=O)[C@H](O)CO)c1ncnc2[nH]ccc12
PDB

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n/an/a 203n/an/an/an/an/an/a



Jiangsu Hengrui Medicine Co., Ltd.

US Patent


Assay Description
JAK2: In vitro kinase assays described below can be used to determine the activity of a test compound for inhibiting the activity of JAK2 kinase. The...


US Patent US10428074 (2019)


BindingDB Entry DOI: 10.7270/Q26D5WC6
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%