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Patent code US10428108

Compile Data Set for Download or QSAR
Found 98 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Serine protease HTRA1


(Homo sapiens (Human))
BDBM415679
PNG
(US10428108, Example 88)
Show SMILES CC(C)[C@H](NC(=O)[C@@H](NC(=O)CC(Oc1cccc(Cl)c1)c1ccc(Cl)c(Cl)c1)c1ccccc1)C(=O)C(F)(F)C(=O)NCC(F)(F)F
Show InChI InChI=1S/C32H29Cl3F5N3O5/c1-17(2)26(28(45)32(39,40)30(47)41-16-31(36,37)38)43-29(46)27(18-7-4-3-5-8-18)42-25(44)15-24(19-11-12-22(34)23(35)13-19)48-21-10-6-9-20(33)14-21/h3-14,17,24,26-27H,15-16H2,1-2H3,(H,41,47)(H,42,44)(H,43,46)/t24?,26-,27-/m0/s1
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n/an/a 2n/an/an/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore, w...


US Patent US10428108 (2019)


BindingDB Entry DOI: 10.7270/Q2JQ13DT
More data for this
Ligand-Target Pair
Serine protease HTRA1


(Homo sapiens (Human))
BDBM415662
PNG
(US10428108, Example 72 | US10428108, Example 93)
Show SMILES CC(C)[C@H](NC(=O)[C@@H](NC(=O)CC(Oc1ccc(Cl)cc1)c1ccc(Cl)c(Cl)c1)c1ccccc1)C(=O)C(F)(F)C(=O)NCC(F)(F)F
Show InChI InChI=1S/C32H29Cl3F5N3O5/c1-17(2)26(28(45)32(39,40)30(47)41-16-31(36,37)38)43-29(46)27(18-6-4-3-5-7-18)42-25(44)15-24(19-8-13-22(34)23(35)14-19)48-21-11-9-20(33)10-12-21/h3-14,17,24,26-27H,15-16H2,1-2H3,(H,41,47)(H,42,44)(H,43,46)/t24?,26-,27-/m0/s1
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Hoffmann-La Roche Inc.

US Patent


Assay Description
Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore, w...


US Patent US10428108 (2019)


BindingDB Entry DOI: 10.7270/Q2JQ13DT
More data for this
Ligand-Target Pair
Serine protease HTRA1


(Homo sapiens (Human))
BDBM415659
PNG
(US10428108, Example 69)
Show SMILES CC(C)[C@H](NC(=O)[C@@H](NC(=O)\C=C\c1ccc(Cl)cc1)c1ccc(Cl)cc1)C(=O)C(F)(F)C(=O)NCC(F)(F)F
Show InChI InChI=1S/C26H24Cl2F5N3O4/c1-14(2)20(22(38)26(32,33)24(40)34-13-25(29,30)31)36-23(39)21(16-6-10-18(28)11-7-16)35-19(37)12-5-15-3-8-17(27)9-4-15/h3-12,14,20-21H,13H2,1-2H3,(H,34,40)(H,35,37)(H,36,39)/b12-5+/t20-,21-/m0/s1
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Hoffmann-La Roche Inc.

US Patent


Assay Description
Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore, w...


US Patent US10428108 (2019)


BindingDB Entry DOI: 10.7270/Q2JQ13DT
More data for this
Ligand-Target Pair
Serine protease HTRA1


(Homo sapiens (Human))
BDBM415683
PNG
(US10428108, Example 92)
Show SMILES CC(C)[C@H](NC(=O)[C@@H](NC(=O)C[C@H](Oc1ccc(Cl)cc1)c1ccc(Cl)c(Cl)c1)c1ccc(Cl)cc1)C(=O)C(F)(F)C(=O)NCC(F)(F)F
Show InChI InChI=1S/C32H28Cl4F5N3O5/c1-16(2)26(28(46)32(40,41)30(48)42-15-31(37,38)39)44-29(47)27(17-3-6-19(33)7-4-17)43-25(45)14-24(18-5-12-22(35)23(36)13-18)49-21-10-8-20(34)9-11-21/h3-13,16,24,26-27H,14-15H2,1-2H3,(H,42,48)(H,43,45)(H,44,47)/t24-,26-,27-/m0/s1
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n/an/a 3n/an/an/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore, w...


US Patent US10428108 (2019)


BindingDB Entry DOI: 10.7270/Q2JQ13DT
More data for this
Ligand-Target Pair
Serine protease HTRA1


(Homo sapiens (Human))
BDBM415661
PNG
(US10428108, Example 71)
Show SMILES CC(C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CC(Oc1ccccc1)c1ccc(Cl)c(Cl)c1)C(=O)C(F)(F)C(=O)NCC(F)(F)F
Show InChI InChI=1S/C33H32Cl2F5N3O5/c1-19(2)28(29(45)33(39,40)31(47)41-18-32(36,37)38)43-30(46)25(15-20-9-5-3-6-10-20)42-27(44)17-26(48-22-11-7-4-8-12-22)21-13-14-23(34)24(35)16-21/h3-14,16,19,25-26,28H,15,17-18H2,1-2H3,(H,41,47)(H,42,44)(H,43,46)/t25-,26?,28-/m0/s1
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Hoffmann-La Roche Inc.

US Patent


Assay Description
Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore, w...


US Patent US10428108 (2019)


BindingDB Entry DOI: 10.7270/Q2JQ13DT
More data for this
Ligand-Target Pair
Serine protease HTRA1


(Homo sapiens (Human))
BDBM415671
PNG
(US10428108, Example 81)
Show SMILES CC(C)[C@H](NC(=O)[C@@H](NC(=O)C[C@H](Oc1cccc(Cl)c1)c1ccccc1)c1ccccc1)C(=O)C(F)(F)C(=O)NCC(F)(F)F
Show InChI InChI=1S/C32H31ClF5N3O5/c1-19(2)26(28(43)32(37,38)30(45)39-18-31(34,35)36)41-29(44)27(21-12-7-4-8-13-21)40-25(42)17-24(20-10-5-3-6-11-20)46-23-15-9-14-22(33)16-23/h3-16,19,24,26-27H,17-18H2,1-2H3,(H,39,45)(H,40,42)(H,41,44)/t24-,26-,27-/m0/s1
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Hoffmann-La Roche Inc.

US Patent


Assay Description
Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore, w...


US Patent US10428108 (2019)


BindingDB Entry DOI: 10.7270/Q2JQ13DT
More data for this
Ligand-Target Pair
Serine protease HTRA1


(Homo sapiens (Human))
BDBM415680
PNG
(US10428108, Example 89)
Show SMILES CC(C)[C@H](NC(=O)[C@@H](NC(=O)CC(Oc1cccc(Cl)c1)c1ccc(Cl)c(Cl)c1)c1ccc(Cl)cc1)C(=O)C(F)(F)C(=O)NCC(F)(F)F
Show InChI InChI=1S/C32H28Cl4F5N3O5/c1-16(2)26(28(46)32(40,41)30(48)42-15-31(37,38)39)44-29(47)27(17-6-9-19(33)10-7-17)43-25(45)14-24(18-8-11-22(35)23(36)12-18)49-21-5-3-4-20(34)13-21/h3-13,16,24,26-27H,14-15H2,1-2H3,(H,42,48)(H,43,45)(H,44,47)/t24?,26-,27-/m0/s1
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Hoffmann-La Roche Inc.

US Patent


Assay Description
Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore, w...


US Patent US10428108 (2019)


BindingDB Entry DOI: 10.7270/Q2JQ13DT
More data for this
Ligand-Target Pair
Serine protease HTRA1


(Homo sapiens (Human))
BDBM415665
PNG
(US10428108, Example 75)
Show SMILES COc1ccc(cc1)C(CC(=O)N[C@H](C(=O)N[C@@H](C(C)C)C(=O)C(F)(F)C(=O)NCC(F)(F)F)c1ccccc1)c1cc(F)cc(F)c1
Show InChI InChI=1S/C33H32F7N3O5/c1-18(2)27(29(45)33(39,40)31(47)41-17-32(36,37)38)43-30(46)28(20-7-5-4-6-8-20)42-26(44)16-25(19-9-11-24(48-3)12-10-19)21-13-22(34)15-23(35)14-21/h4-15,18,25,27-28H,16-17H2,1-3H3,(H,41,47)(H,42,44)(H,43,46)/t25?,27-,28-/m0/s1
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Hoffmann-La Roche Inc.

US Patent


Assay Description
Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore, w...


US Patent US10428108 (2019)


BindingDB Entry DOI: 10.7270/Q2JQ13DT
More data for this
Ligand-Target Pair
Serine protease HTRA1


(Homo sapiens (Human))
BDBM415690
PNG
(US10428108, Example 98)
Show SMILES COc1ccc(cc1)[C@H](NC(=O)CC(Oc1cncc(Cl)c1)c1cccc(Cl)c1)C(=O)N[C@@H](C(C)C)C(=O)C(F)(F)C(=O)NCC(F)(F)F
Show InChI InChI=1S/C32H31Cl2F5N4O6/c1-17(2)26(28(45)32(38,39)30(47)41-16-31(35,36)37)43-29(46)27(18-7-9-22(48-3)10-8-18)42-25(44)13-24(19-5-4-6-20(33)11-19)49-23-12-21(34)14-40-15-23/h4-12,14-15,17,24,26-27H,13,16H2,1-3H3,(H,41,47)(H,42,44)(H,43,46)/t24?,26-,27-/m0/s1
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Hoffmann-La Roche Inc.

US Patent


Assay Description
Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore, w...


US Patent US10428108 (2019)


BindingDB Entry DOI: 10.7270/Q2JQ13DT
More data for this
Ligand-Target Pair
Serine protease HTRA1


(Homo sapiens (Human))
BDBM415663
PNG
(US10428108, Example 73)
Show SMILES CC(C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CC(Oc1ccc(Cl)cc1)c1ccc(Cl)c(Cl)c1)C(=O)C(F)(F)C(=O)NCC(F)(F)F
Show InChI InChI=1S/C33H31Cl3F5N3O5/c1-18(2)28(29(46)33(40,41)31(48)42-17-32(37,38)39)44-30(47)25(14-19-6-4-3-5-7-19)43-27(45)16-26(20-8-13-23(35)24(36)15-20)49-22-11-9-21(34)10-12-22/h3-13,15,18,25-26,28H,14,16-17H2,1-2H3,(H,42,48)(H,43,45)(H,44,47)/t25-,26?,28-/m0/s1
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Hoffmann-La Roche Inc.

US Patent


Assay Description
Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore, w...


US Patent US10428108 (2019)


BindingDB Entry DOI: 10.7270/Q2JQ13DT
More data for this
Ligand-Target Pair
Serine protease HTRA1


(Homo sapiens (Human))
BDBM415655
PNG
(US10428108, Example 65 | US10428108, Example 74 | ...)
Show SMILES CC(C)[C@H](NC(=O)[C@@H](NC(=O)CC(c1ccccc1)c1cc(Cl)cc(Cl)c1)c1ccccc1)C(=O)C(F)(F)C(=O)NCC(F)(F)F
Show InChI InChI=1S/C32H30Cl2F5N3O4/c1-18(2)26(28(44)32(38,39)30(46)40-17-31(35,36)37)42-29(45)27(20-11-7-4-8-12-20)41-25(43)16-24(19-9-5-3-6-10-19)21-13-22(33)15-23(34)14-21/h3-15,18,24,26-27H,16-17H2,1-2H3,(H,40,46)(H,41,43)(H,42,45)/t24?,26-,27-/m0/s1
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Hoffmann-La Roche Inc.

US Patent


Assay Description
Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore, w...


US Patent US10428108 (2019)


BindingDB Entry DOI: 10.7270/Q2JQ13DT
More data for this
Ligand-Target Pair
Serine protease HTRA1


(Homo sapiens (Human))
BDBM415667
PNG
(US10428108, Example 77 | US10428108, Example 79)
Show SMILES CC(C)[C@H](NC(=O)[C@@H](NC(=O)CC(c1ccccc1)c1cc(Cl)cc(Cl)c1)c1ccc(Cl)cc1)C(=O)C(F)(F)C(=O)NCC(F)(F)F
Show InChI InChI=1S/C32H29Cl3F5N3O4/c1-17(2)26(28(45)32(39,40)30(47)41-16-31(36,37)38)43-29(46)27(19-8-10-21(33)11-9-19)42-25(44)15-24(18-6-4-3-5-7-18)20-12-22(34)14-23(35)13-20/h3-14,17,24,26-27H,15-16H2,1-2H3,(H,41,47)(H,42,44)(H,43,46)/t24?,26-,27-/m0/s1
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Hoffmann-La Roche Inc.

US Patent


Assay Description
Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore, w...


US Patent US10428108 (2019)


BindingDB Entry DOI: 10.7270/Q2JQ13DT
More data for this
Ligand-Target Pair
Serine protease HTRA1


(Homo sapiens (Human))
BDBM415670
PNG
(US10428108, Example 80)
Show SMILES CC(C)[C@H](NC(=O)[C@@H](NC(=O)C[C@H](Oc1cccc(Cl)c1)c1ccccc1)c1ccc(Cl)cc1)C(=O)C(F)(F)C(=O)NCC(F)(F)F
Show InChI InChI=1S/C32H30Cl2F5N3O5/c1-18(2)26(28(44)32(38,39)30(46)40-17-31(35,36)37)42-29(45)27(20-11-13-21(33)14-12-20)41-25(43)16-24(19-7-4-3-5-8-19)47-23-10-6-9-22(34)15-23/h3-15,18,24,26-27H,16-17H2,1-2H3,(H,40,46)(H,41,43)(H,42,45)/t24-,26-,27-/m0/s1
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Hoffmann-La Roche Inc.

US Patent


Assay Description
Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore, w...


US Patent US10428108 (2019)


BindingDB Entry DOI: 10.7270/Q2JQ13DT
More data for this
Ligand-Target Pair
Serine protease HTRA1


(Homo sapiens (Human))
BDBM415646
PNG
(US10428108, Example 56)
Show SMILES CC(C)[C@H](NC(=O)[C@@H](NC(=O)COc1cc(Cl)cc(Cl)c1)c1ccc(F)cc1)C(=O)C(F)(F)C(=O)NCC(F)(F)F
Show InChI InChI=1S/C25H23Cl2F6N3O5/c1-12(2)19(21(38)25(32,33)23(40)34-11-24(29,30)31)36-22(39)20(13-3-5-16(28)6-4-13)35-18(37)10-41-17-8-14(26)7-15(27)9-17/h3-9,12,19-20H,10-11H2,1-2H3,(H,34,40)(H,35,37)(H,36,39)/t19-,20-/m0/s1
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Hoffmann-La Roche Inc.

US Patent


Assay Description
Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore, w...


US Patent US10428108 (2019)


BindingDB Entry DOI: 10.7270/Q2JQ13DT
More data for this
Ligand-Target Pair
Serine protease HTRA1


(Homo sapiens (Human))
BDBM415645
PNG
(US10428108, Example 55)
Show SMILES CC(C)[C@H](NC(=O)[C@@H](NC(=O)COc1cc(Cl)cc(Cl)c1)c1ccccc1)C(=O)C(F)(F)C(=O)NCC(F)(F)F
Show InChI InChI=1S/C25H24Cl2F5N3O5/c1-13(2)19(21(37)25(31,32)23(39)33-12-24(28,29)30)35-22(38)20(14-6-4-3-5-7-14)34-18(36)11-40-17-9-15(26)8-16(27)10-17/h3-10,13,19-20H,11-12H2,1-2H3,(H,33,39)(H,34,36)(H,35,38)/t19-,20-/m0/s1
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Hoffmann-La Roche Inc.

US Patent


Assay Description
Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore, w...


US Patent US10428108 (2019)


BindingDB Entry DOI: 10.7270/Q2JQ13DT
More data for this
Ligand-Target Pair
Serine protease HTRA1


(Homo sapiens (Human))
BDBM415660
PNG
(US10428108, Example 70)
Show SMILES CC(C)[C@H](NC(=O)[C@@H](NC(=O)CC(Oc1ccccc1)c1ccc(Cl)c(Cl)c1)c1ccccc1)C(=O)C(F)(F)C(=O)NCC(F)(F)F
Show InChI InChI=1S/C32H30Cl2F5N3O5/c1-18(2)26(28(44)32(38,39)30(46)40-17-31(35,36)37)42-29(45)27(19-9-5-3-6-10-19)41-25(43)16-24(47-21-11-7-4-8-12-21)20-13-14-22(33)23(34)15-20/h3-15,18,24,26-27H,16-17H2,1-2H3,(H,40,46)(H,41,43)(H,42,45)/t24?,26-,27-/m0/s1
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Hoffmann-La Roche Inc.

US Patent


Assay Description
Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore, w...


US Patent US10428108 (2019)


BindingDB Entry DOI: 10.7270/Q2JQ13DT
More data for this
Ligand-Target Pair
Serine protease HTRA1


(Homo sapiens (Human))
BDBM415652
PNG
(US10428108, Example 62 | US10428108, Example 94)
Show SMILES CC(C)[C@H](NC(=O)[C@@H](NC(=O)\C=C\c1ccc(Cl)c(Cl)c1)c1ccccc1)C(=O)C(F)(F)C(=O)NCC(F)(F)F
Show InChI InChI=1S/C26H24Cl2F5N3O4/c1-14(2)20(22(38)26(32,33)24(40)34-13-25(29,30)31)36-23(39)21(16-6-4-3-5-7-16)35-19(37)11-9-15-8-10-17(27)18(28)12-15/h3-12,14,20-21H,13H2,1-2H3,(H,34,40)(H,35,37)(H,36,39)/b11-9+/t20-,21-/m0/s1
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Hoffmann-La Roche Inc.

US Patent


Assay Description
Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore, w...


US Patent US10428108 (2019)


BindingDB Entry DOI: 10.7270/Q2JQ13DT
More data for this
Ligand-Target Pair
Serine protease HTRA1


(Homo sapiens (Human))
BDBM415648
PNG
(US10428108, Example 58)
Show SMILES CC(C)[C@H](NC(=O)[C@@H](NC(=O)CC(c1ccccc1)c1ccc(Cl)c(Cl)c1)c1ccc(Cl)cc1)C(=O)C(F)(F)C(=O)NCC(F)(F)F
Show InChI InChI=1S/C32H29Cl3F5N3O4/c1-17(2)26(28(45)32(39,40)30(47)41-16-31(36,37)38)43-29(46)27(19-8-11-21(33)12-9-19)42-25(44)15-22(18-6-4-3-5-7-18)20-10-13-23(34)24(35)14-20/h3-14,17,22,26-27H,15-16H2,1-2H3,(H,41,47)(H,42,44)(H,43,46)/t22?,26-,27-/m0/s1
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Hoffmann-La Roche Inc.

US Patent


Assay Description
Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore, w...


US Patent US10428108 (2019)


BindingDB Entry DOI: 10.7270/Q2JQ13DT
More data for this
Ligand-Target Pair
Serine protease HTRA1


(Homo sapiens (Human))
BDBM415674
PNG
((4S)-4-[[(2S)-2-[[2-(3,5-Dichlorophenoxy)acetyl]am...)
Show SMILES COc1ccc(cc1)[C@H](NC(=O)COc1cc(Cl)cc(Cl)c1)C(=O)N[C@@H](C(C)C)C(=O)C(F)(F)C(=O)NCC(F)(F)F
Show InChI InChI=1S/C26H26Cl2F5N3O6/c1-13(2)20(22(38)26(32,33)24(40)34-12-25(29,30)31)36-23(39)21(14-4-6-17(41-3)7-5-14)35-19(37)11-42-18-9-15(27)8-16(28)10-18/h4-10,13,20-21H,11-12H2,1-3H3,(H,34,40)(H,35,37)(H,36,39)/t20-,21-/m0/s1
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Hoffmann-La Roche Inc.

US Patent


Assay Description
Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore, w...


US Patent US10428108 (2019)


BindingDB Entry DOI: 10.7270/Q2JQ13DT
More data for this
Ligand-Target Pair
Serine protease HTRA1


(Homo sapiens (Human))
BDBM415649
PNG
(US10428108, Example 59)
Show SMILES CC(C)[C@H](NC(=O)[C@@H](NC(=O)CCc1ccc(Cl)c(Cl)c1)c1ccccc1)C(=O)C(F)(F)C(=O)NCC(F)(F)F
Show InChI InChI=1S/C26H26Cl2F5N3O4/c1-14(2)20(22(38)26(32,33)24(40)34-13-25(29,30)31)36-23(39)21(16-6-4-3-5-7-16)35-19(37)11-9-15-8-10-17(27)18(28)12-15/h3-8,10,12,14,20-21H,9,11,13H2,1-2H3,(H,34,40)(H,35,37)(H,36,39)/t20-,21-/m0/s1
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Hoffmann-La Roche Inc.

US Patent


Assay Description
Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore, w...


US Patent US10428108 (2019)


BindingDB Entry DOI: 10.7270/Q2JQ13DT
More data for this
Ligand-Target Pair
Serine protease HTRA1


(Homo sapiens (Human))
BDBM415639
PNG
(US10428108, Example 50)
Show SMILES CC(C)[C@H](NC(=O)[C@@H](NC(=O)COc1cc(Cl)cc(Cl)c1)c1ccc(Cl)cc1)C(=O)C(F)(F)C(=O)NCC(F)(F)F
Show InChI InChI=1S/C25H23Cl3F5N3O5/c1-12(2)19(21(38)25(32,33)23(40)34-11-24(29,30)31)36-22(39)20(13-3-5-14(26)6-4-13)35-18(37)10-41-17-8-15(27)7-16(28)9-17/h3-9,12,19-20H,10-11H2,1-2H3,(H,34,40)(H,35,37)(H,36,39)/t19-,20-/m0/s1
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Hoffmann-La Roche Inc.

US Patent


Assay Description
Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore, w...


US Patent US10428108 (2019)


BindingDB Entry DOI: 10.7270/Q2JQ13DT
More data for this
Ligand-Target Pair
Serine protease HTRA1


(Homo sapiens (Human))
BDBM415667
PNG
(US10428108, Example 77 | US10428108, Example 79)
Show SMILES CC(C)[C@H](NC(=O)[C@@H](NC(=O)CC(c1ccccc1)c1cc(Cl)cc(Cl)c1)c1ccc(Cl)cc1)C(=O)C(F)(F)C(=O)NCC(F)(F)F
Show InChI InChI=1S/C32H29Cl3F5N3O4/c1-17(2)26(28(45)32(39,40)30(47)41-16-31(36,37)38)43-29(46)27(19-8-10-21(33)11-9-19)42-25(44)15-24(18-6-4-3-5-7-18)20-12-22(34)14-23(35)13-20/h3-14,17,24,26-27H,15-16H2,1-2H3,(H,41,47)(H,42,44)(H,43,46)/t24?,26-,27-/m0/s1
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Hoffmann-La Roche Inc.

US Patent


Assay Description
Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore, w...


US Patent US10428108 (2019)


BindingDB Entry DOI: 10.7270/Q2JQ13DT
More data for this
Ligand-Target Pair
Serine protease HTRA1


(Homo sapiens (Human))
BDBM415644
PNG
(US10428108, Example 54)
Show SMILES COc1ccc(C[C@H](NC(=O)CC(c2ccccc2)c2ccc(Cl)c(Cl)c2)C(=O)N[C@@H](C(C)C)C(=O)C(F)(F)C(=O)NCC(F)(F)F)cc1
Show InChI InChI=1S/C34H34Cl2F5N3O5/c1-19(2)29(30(46)34(40,41)32(48)42-18-33(37,38)39)44-31(47)27(15-20-9-12-23(49-3)13-10-20)43-28(45)17-24(21-7-5-4-6-8-21)22-11-14-25(35)26(36)16-22/h4-14,16,19,24,27,29H,15,17-18H2,1-3H3,(H,42,48)(H,43,45)(H,44,47)/t24?,27-,29-/m0/s1
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Hoffmann-La Roche Inc.

US Patent


Assay Description
Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore, w...


US Patent US10428108 (2019)


BindingDB Entry DOI: 10.7270/Q2JQ13DT
More data for this
Ligand-Target Pair
Serine protease HTRA1


(Homo sapiens (Human))
BDBM415655
PNG
(US10428108, Example 65 | US10428108, Example 74 | ...)
Show SMILES CC(C)[C@H](NC(=O)[C@@H](NC(=O)CC(c1ccccc1)c1cc(Cl)cc(Cl)c1)c1ccccc1)C(=O)C(F)(F)C(=O)NCC(F)(F)F
Show InChI InChI=1S/C32H30Cl2F5N3O4/c1-18(2)26(28(44)32(38,39)30(46)40-17-31(35,36)37)42-29(45)27(20-11-7-4-8-12-20)41-25(43)16-24(19-9-5-3-6-10-19)21-13-22(33)15-23(34)14-21/h3-15,18,24,26-27H,16-17H2,1-2H3,(H,40,46)(H,41,43)(H,42,45)/t24?,26-,27-/m0/s1
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Hoffmann-La Roche Inc.

US Patent


Assay Description
Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore, w...


US Patent US10428108 (2019)


BindingDB Entry DOI: 10.7270/Q2JQ13DT
More data for this
Ligand-Target Pair
Serine protease HTRA1


(Homo sapiens (Human))
BDBM415678
PNG
(US10428108, Example 87)
Show SMILES COc1ccc(cc1)[C@H](NC(=O)CC(c1ccccc1)c1ccc(Cl)c(Cl)c1)C(=O)N[C@@H](C(C)C)C(=O)C(F)(F)C(=O)NCC(F)(F)F
Show InChI InChI=1S/C33H32Cl2F5N3O5/c1-18(2)27(29(45)33(39,40)31(47)41-17-32(36,37)38)43-30(46)28(20-9-12-22(48-3)13-10-20)42-26(44)16-23(19-7-5-4-6-8-19)21-11-14-24(34)25(35)15-21/h4-15,18,23,27-28H,16-17H2,1-3H3,(H,41,47)(H,42,44)(H,43,46)/t23?,27-,28-/m0/s1
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Hoffmann-La Roche Inc.

US Patent


Assay Description
Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore, w...


US Patent US10428108 (2019)


BindingDB Entry DOI: 10.7270/Q2JQ13DT
More data for this
Ligand-Target Pair
Serine protease HTRA1


(Homo sapiens (Human))
BDBM415688
PNG
(US10428108, Example 96)
Show SMILES CC(C)[C@H](NC(=O)[C@@H](NC(=O)CC(Oc1cccc(Cl)c1)c1cncc(Cl)c1)c1ccccc1)C(=O)C(F)(F)C(=O)NCC(F)(F)F
Show InChI InChI=1S/C31H29Cl2F5N4O5/c1-17(2)25(27(44)31(37,38)29(46)40-16-30(34,35)36)42-28(45)26(18-7-4-3-5-8-18)41-24(43)13-23(19-11-21(33)15-39-14-19)47-22-10-6-9-20(32)12-22/h3-12,14-15,17,23,25-26H,13,16H2,1-2H3,(H,40,46)(H,41,43)(H,42,45)/t23?,25-,26-/m0/s1
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Hoffmann-La Roche Inc.

US Patent


Assay Description
Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore, w...


US Patent US10428108 (2019)


BindingDB Entry DOI: 10.7270/Q2JQ13DT
More data for this
Ligand-Target Pair
Serine protease HTRA1


(Homo sapiens (Human))
BDBM415655
PNG
(US10428108, Example 65 | US10428108, Example 74 | ...)
Show SMILES CC(C)[C@H](NC(=O)[C@@H](NC(=O)CC(c1ccccc1)c1cc(Cl)cc(Cl)c1)c1ccccc1)C(=O)C(F)(F)C(=O)NCC(F)(F)F
Show InChI InChI=1S/C32H30Cl2F5N3O4/c1-18(2)26(28(44)32(38,39)30(46)40-17-31(35,36)37)42-29(45)27(20-11-7-4-8-12-20)41-25(43)16-24(19-9-5-3-6-10-19)21-13-22(33)15-23(34)14-21/h3-15,18,24,26-27H,16-17H2,1-2H3,(H,40,46)(H,41,43)(H,42,45)/t24?,26-,27-/m0/s1
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Hoffmann-La Roche Inc.

US Patent


Assay Description
Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore, w...


US Patent US10428108 (2019)


BindingDB Entry DOI: 10.7270/Q2JQ13DT
More data for this
Ligand-Target Pair
Serine protease HTRA1


(Homo sapiens (Human))
BDBM415647
PNG
(US10428108, Example 57)
Show SMILES CC(C)[C@H](NC(=O)[C@@H](NC(=O)CC(c1ccccc1)c1ccc(Cl)c(Cl)c1)c1ccccc1)C(=O)C(F)(F)C(=O)NCC(F)(F)F
Show InChI InChI=1S/C32H30Cl2F5N3O4/c1-18(2)26(28(44)32(38,39)30(46)40-17-31(35,36)37)42-29(45)27(20-11-7-4-8-12-20)41-25(43)16-22(19-9-5-3-6-10-19)21-13-14-23(33)24(34)15-21/h3-15,18,22,26-27H,16-17H2,1-2H3,(H,40,46)(H,41,43)(H,42,45)/t22?,26-,27-/m0/s1
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Hoffmann-La Roche Inc.

US Patent


Assay Description
Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore, w...


US Patent US10428108 (2019)


BindingDB Entry DOI: 10.7270/Q2JQ13DT
More data for this
Ligand-Target Pair
Serine protease HTRA1


(Homo sapiens (Human))
BDBM415642
PNG
(US10428108, Example 53)
Show SMILES CC(C)[C@H](NC(=O)[C@H](Cc1ccc(Cl)cc1)NC(=O)CC(c1ccccc1)c1ccc(Cl)c(Cl)c1)C(=O)C(F)(F)C(=O)NCC(F)(F)F
Show InChI InChI=1S/C33H31Cl3F5N3O4/c1-18(2)28(29(46)33(40,41)31(48)42-17-32(37,38)39)44-30(47)26(14-19-8-11-22(34)12-9-19)43-27(45)16-23(20-6-4-3-5-7-20)21-10-13-24(35)25(36)15-21/h3-13,15,18,23,26,28H,14,16-17H2,1-2H3,(H,42,48)(H,43,45)(H,44,47)/t23?,26-,28-/m0/s1
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Hoffmann-La Roche Inc.

US Patent


Assay Description
Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore, w...


US Patent US10428108 (2019)


BindingDB Entry DOI: 10.7270/Q2JQ13DT
More data for this
Ligand-Target Pair
Serine protease HTRA1


(Homo sapiens (Human))
BDBM415616
PNG
(US10428108, Example 27)
Show SMILES CC(C)[C@H](NC(=O)[C@H](Cc1ccc(Cl)cc1)NC(=O)COc1cc(Cl)cc(Cl)c1)C(=O)C(F)(F)C(=O)NCC(F)(F)F
Show InChI InChI=1S/C26H25Cl3F5N3O5/c1-13(2)21(22(39)26(33,34)24(41)35-12-25(30,31)32)37-23(40)19(7-14-3-5-15(27)6-4-14)36-20(38)11-42-18-9-16(28)8-17(29)10-18/h3-6,8-10,13,19,21H,7,11-12H2,1-2H3,(H,35,41)(H,36,38)(H,37,40)/t19-,21-/m0/s1
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Hoffmann-La Roche Inc.

US Patent


Assay Description
Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore, w...


US Patent US10428108 (2019)


BindingDB Entry DOI: 10.7270/Q2JQ13DT
More data for this
Ligand-Target Pair
Serine protease HTRA1


(Homo sapiens (Human))
BDBM415654
PNG
(US10428108, Example 64)
Show SMILES CC(C)[C@H](NC(=O)[C@@H](NC(=O)\C=C\c1ccc(Cl)cc1)c1ccccc1)C(=O)C(F)(F)C(=O)NCC(F)(F)F
Show InChI InChI=1S/C26H25ClF5N3O4/c1-15(2)20(22(37)26(31,32)24(39)33-14-25(28,29)30)35-23(38)21(17-6-4-3-5-7-17)34-19(36)13-10-16-8-11-18(27)12-9-16/h3-13,15,20-21H,14H2,1-2H3,(H,33,39)(H,34,36)(H,35,38)/b13-10+/t20-,21-/m0/s1
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Hoffmann-La Roche Inc.

US Patent


Assay Description
Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore, w...


US Patent US10428108 (2019)


BindingDB Entry DOI: 10.7270/Q2JQ13DT
More data for this
Ligand-Target Pair
Serine protease HTRA1


(Homo sapiens (Human))
BDBM415677
PNG
(US10428108, Example 86)
Show SMILES COc1ccc(cc1)[C@H](NC(=O)\C=C\c1ccc(Cl)cc1)C(=O)N[C@@H](C(C)C)C(=O)C(F)(F)C(=O)NCC(F)(F)F
Show InChI InChI=1S/C27H27ClF5N3O5/c1-15(2)21(23(38)27(32,33)25(40)34-14-26(29,30)31)36-24(39)22(17-7-11-19(41-3)12-8-17)35-20(37)13-6-16-4-9-18(28)10-5-16/h4-13,15,21-22H,14H2,1-3H3,(H,34,40)(H,35,37)(H,36,39)/b13-6+/t21-,22-/m0/s1
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Hoffmann-La Roche Inc.

US Patent


Assay Description
Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore, w...


US Patent US10428108 (2019)


BindingDB Entry DOI: 10.7270/Q2JQ13DT
More data for this
Ligand-Target Pair
Serine protease HTRA1


(Homo sapiens (Human))
BDBM415689
PNG
(US10428108, Example 97)
Show SMILES CC(C)[C@H](NC(=O)[C@@H](NC(=O)CC(Oc1cccnc1)c1cccc(Cl)c1)c1ccccc1)C(=O)C(F)(F)C(=O)NCC(F)(F)F
Show InChI InChI=1S/C31H30ClF5N4O5/c1-18(2)25(27(43)31(36,37)29(45)39-17-30(33,34)35)41-28(44)26(19-8-4-3-5-9-19)40-24(42)15-23(20-10-6-11-21(32)14-20)46-22-12-7-13-38-16-22/h3-14,16,18,23,25-26H,15,17H2,1-2H3,(H,39,45)(H,40,42)(H,41,44)/t23?,25-,26-/m0/s1
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Hoffmann-La Roche Inc.

US Patent


Assay Description
Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore, w...


US Patent US10428108 (2019)


BindingDB Entry DOI: 10.7270/Q2JQ13DT
More data for this
Ligand-Target Pair
Serine protease HTRA1


(Homo sapiens (Human))
BDBM415617
PNG
(US10428108, Example 28)
Show SMILES CC(C)[C@H](NC(=O)[C@H](Cc1ccc(Cl)c(Cl)c1)NC(=O)COc1cc(Cl)cc(Cl)c1)C(=O)C(F)(F)C(=O)NCC(F)(F)F
Show InChI InChI=1S/C26H24Cl4F5N3O5/c1-12(2)21(22(40)26(34,35)24(42)36-11-25(31,32)33)38-23(41)19(6-13-3-4-17(29)18(30)5-13)37-20(39)10-43-16-8-14(27)7-15(28)9-16/h3-5,7-9,12,19,21H,6,10-11H2,1-2H3,(H,36,42)(H,37,39)(H,38,41)/t19-,21-/m0/s1
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Hoffmann-La Roche Inc.

US Patent


Assay Description
Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore, w...


US Patent US10428108 (2019)


BindingDB Entry DOI: 10.7270/Q2JQ13DT
More data for this
Ligand-Target Pair
Serine protease HTRA1


(Homo sapiens (Human))
BDBM415638
PNG
(US10428108, Example 49)
Show SMILES CC(C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)\C=C\c1cc(Cl)cc(Cl)c1)C(=O)C(F)(F)C(=O)NCC(F)(F)F
Show InChI InChI=1S/C27H26Cl2F5N3O4/c1-15(2)22(23(39)27(33,34)25(41)35-14-26(30,31)32)37-24(40)20(12-16-6-4-3-5-7-16)36-21(38)9-8-17-10-18(28)13-19(29)11-17/h3-11,13,15,20,22H,12,14H2,1-2H3,(H,35,41)(H,36,38)(H,37,40)/b9-8+/t20-,22-/m0/s1
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Hoffmann-La Roche Inc.

US Patent


Assay Description
Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore, w...


US Patent US10428108 (2019)


BindingDB Entry DOI: 10.7270/Q2JQ13DT
More data for this
Ligand-Target Pair
Serine protease HTRA1


(Homo sapiens (Human))
BDBM415641
PNG
(US10428108, Example 52)
Show SMILES COc1ccc(cc1)C(CC(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](C(C)C)C(=O)C(F)(F)C(=O)NCC(F)(F)F)c1cc(Cl)cc(Cl)c1
Show InChI InChI=1S/C34H34Cl2F5N3O5/c1-19(2)29(30(46)34(40,41)32(48)42-18-33(37,38)39)44-31(47)27(13-20-7-5-4-6-8-20)43-28(45)17-26(21-9-11-25(49-3)12-10-21)22-14-23(35)16-24(36)15-22/h4-12,14-16,19,26-27,29H,13,17-18H2,1-3H3,(H,42,48)(H,43,45)(H,44,47)/t26?,27-,29-/m0/s1
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Hoffmann-La Roche Inc.

US Patent


Assay Description
Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore, w...


US Patent US10428108 (2019)


BindingDB Entry DOI: 10.7270/Q2JQ13DT
More data for this
Ligand-Target Pair
Serine protease HTRA1


(Homo sapiens (Human))
BDBM415653
PNG
(US10428108, Example 63)
Show SMILES CC(C)[C@H](NC(=O)[C@@H](NC(=O)\C=C\c1cccc(Cl)c1)c1ccccc1)C(=O)C(F)(F)C(=O)NCC(F)(F)F
Show InChI InChI=1S/C26H25ClF5N3O4/c1-15(2)20(22(37)26(31,32)24(39)33-14-25(28,29)30)35-23(38)21(17-8-4-3-5-9-17)34-19(36)12-11-16-7-6-10-18(27)13-16/h3-13,15,20-21H,14H2,1-2H3,(H,33,39)(H,34,36)(H,35,38)/b12-11+/t20-,21-/m0/s1
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Hoffmann-La Roche Inc.

US Patent


Assay Description
Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore, w...


US Patent US10428108 (2019)


BindingDB Entry DOI: 10.7270/Q2JQ13DT
More data for this
Ligand-Target Pair
Serine protease HTRA1


(Homo sapiens (Human))
BDBM415656
PNG
(US10428108, Example 66)
Show SMILES CC(C)[C@H](NC(=O)[C@@H](NC(=O)\C=C\c1ccc(Cl)c(Cl)c1)c1ccc(Cl)cc1)C(=O)C(F)(F)C(=O)NCC(F)(F)F
Show InChI InChI=1S/C26H23Cl3F5N3O4/c1-13(2)20(22(39)26(33,34)24(41)35-12-25(30,31)32)37-23(40)21(15-5-7-16(27)8-6-15)36-19(38)10-4-14-3-9-17(28)18(29)11-14/h3-11,13,20-21H,12H2,1-2H3,(H,35,41)(H,36,38)(H,37,40)/b10-4+/t20-,21-/m0/s1
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Hoffmann-La Roche Inc.

US Patent


Assay Description
Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore, w...


US Patent US10428108 (2019)


BindingDB Entry DOI: 10.7270/Q2JQ13DT
More data for this
Ligand-Target Pair
Serine protease HTRA1


(Homo sapiens (Human))
BDBM415629
PNG
(US10428108, Example 40)
Show SMILES CC(C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CC(c1ccccc1)c1ccc(Cl)c(Cl)c1)C(=O)C(F)(F)C(=O)NCC(F)(F)F
Show InChI InChI=1S/C33H32Cl2F5N3O4/c1-19(2)28(29(45)33(39,40)31(47)41-18-32(36,37)38)43-30(46)26(15-20-9-5-3-6-10-20)42-27(44)17-23(21-11-7-4-8-12-21)22-13-14-24(34)25(35)16-22/h3-14,16,19,23,26,28H,15,17-18H2,1-2H3,(H,41,47)(H,42,44)(H,43,46)/t23?,26-,28-/m0/s1
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Hoffmann-La Roche Inc.

US Patent


Assay Description
Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore, w...


US Patent US10428108 (2019)


BindingDB Entry DOI: 10.7270/Q2JQ13DT
More data for this
Ligand-Target Pair
Serine protease HTRA1


(Homo sapiens (Human))
BDBM415666
PNG
(US10428108, Example 76)
Show SMILES COc1ccc(cc1)C(CC(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](C(C)C)C(=O)C(F)(F)C(=O)NCC(F)(F)F)c1cc(F)cc(F)c1
Show InChI InChI=1S/C34H34F7N3O5/c1-19(2)29(30(46)34(40,41)32(48)42-18-33(37,38)39)44-31(47)27(13-20-7-5-4-6-8-20)43-28(45)17-26(21-9-11-25(49-3)12-10-21)22-14-23(35)16-24(36)15-22/h4-12,14-16,19,26-27,29H,13,17-18H2,1-3H3,(H,42,48)(H,43,45)(H,44,47)/t26?,27-,29-/m0/s1
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Hoffmann-La Roche Inc.

US Patent


Assay Description
Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore, w...


US Patent US10428108 (2019)


BindingDB Entry DOI: 10.7270/Q2JQ13DT
More data for this
Ligand-Target Pair
Serine protease HTRA1


(Homo sapiens (Human))
BDBM415597
PNG
(US10428108, Example 9)
Show SMILES CC(C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)COc1cc(Cl)cc(Cl)c1)C(=O)C(F)(F)C(=O)NCC(F)(F)F
Show InChI InChI=1S/C26H26Cl2F5N3O5/c1-14(2)21(22(38)26(32,33)24(40)34-13-25(29,30)31)36-23(39)19(8-15-6-4-3-5-7-15)35-20(37)12-41-18-10-16(27)9-17(28)11-18/h3-7,9-11,14,19,21H,8,12-13H2,1-2H3,(H,34,40)(H,35,37)(H,36,39)/t19-,21-/m0/s1
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Hoffmann-La Roche Inc.

US Patent


Assay Description
Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore, w...


US Patent US10428108 (2019)


BindingDB Entry DOI: 10.7270/Q2JQ13DT
More data for this
Ligand-Target Pair
Serine protease HTRA1


(Homo sapiens (Human))
BDBM415675
PNG
(US10428108, Example 84)
Show SMILES CC(C)[C@H](NC(=O)[C@@H](NC(=O)C[C@H](c1ccccc1)c1cccc(Cl)c1)c1ccccc1)C(=O)C(F)(F)C(=O)NCC(F)(F)F
Show InChI InChI=1S/C32H31ClF5N3O4/c1-19(2)26(28(43)32(37,38)30(45)39-18-31(34,35)36)41-29(44)27(21-12-7-4-8-13-21)40-25(42)17-24(20-10-5-3-6-11-20)22-14-9-15-23(33)16-22/h3-16,19,24,26-27H,17-18H2,1-2H3,(H,39,45)(H,40,42)(H,41,44)/t24-,26+,27+/m1/s1
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Hoffmann-La Roche Inc.

US Patent


Assay Description
Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore, w...


US Patent US10428108 (2019)


BindingDB Entry DOI: 10.7270/Q2JQ13DT
More data for this
Ligand-Target Pair
Serine protease HTRA1


(Homo sapiens (Human))
BDBM415662
PNG
(US10428108, Example 72 | US10428108, Example 93)
Show SMILES CC(C)[C@H](NC(=O)[C@@H](NC(=O)CC(Oc1ccc(Cl)cc1)c1ccc(Cl)c(Cl)c1)c1ccccc1)C(=O)C(F)(F)C(=O)NCC(F)(F)F
Show InChI InChI=1S/C32H29Cl3F5N3O5/c1-17(2)26(28(45)32(39,40)30(47)41-16-31(36,37)38)43-29(46)27(18-6-4-3-5-7-18)42-25(44)15-24(19-8-13-22(34)23(35)14-19)48-21-11-9-20(33)10-12-21/h3-14,17,24,26-27H,15-16H2,1-2H3,(H,41,47)(H,42,44)(H,43,46)/t24?,26-,27-/m0/s1
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Hoffmann-La Roche Inc.

US Patent


Assay Description
Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore, w...


US Patent US10428108 (2019)


BindingDB Entry DOI: 10.7270/Q2JQ13DT
More data for this
Ligand-Target Pair
Serine protease HTRA1


(Homo sapiens (Human))
BDBM415676
PNG
(US10428108, Example 85)
Show SMILES CC(C)[C@H](NC(=O)[C@@H](NC(=O)C[C@H](c1ccc(Cl)cc1)c1cccc(Cl)c1)c1ccccc1)C(=O)C(F)(F)C(=O)NCC(F)(F)F
Show InChI InChI=1S/C32H30Cl2F5N3O4/c1-18(2)26(28(44)32(38,39)30(46)40-17-31(35,36)37)42-29(45)27(20-7-4-3-5-8-20)41-25(43)16-24(19-11-13-22(33)14-12-19)21-9-6-10-23(34)15-21/h3-15,18,24,26-27H,16-17H2,1-2H3,(H,40,46)(H,41,43)(H,42,45)/t24-,26+,27+/m1/s1
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Hoffmann-La Roche Inc.

US Patent


Assay Description
Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore, w...


US Patent US10428108 (2019)


BindingDB Entry DOI: 10.7270/Q2JQ13DT
More data for this
Ligand-Target Pair
Serine protease HTRA1


(Homo sapiens (Human))
BDBM415590
PNG
((4S)-4-[[(2S)-2-[[(E)-3-(3,5-Dichlorophenyl)prop-2...)
Show SMILES CC(C)[C@H](NC(=O)[C@@H](NC(=O)\C=C\c1cc(Cl)cc(Cl)c1)c1ccccc1)C(=O)C(F)(F)C(=O)NCC(F)(F)F
Show InChI InChI=1S/C26H24Cl2F5N3O4/c1-14(2)20(22(38)26(32,33)24(40)34-13-25(29,30)31)36-23(39)21(16-6-4-3-5-7-16)35-19(37)9-8-15-10-17(27)12-18(28)11-15/h3-12,14,20-21H,13H2,1-2H3,(H,34,40)(H,35,37)(H,36,39)/b9-8+/t20-,21-/m0/s1
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Hoffmann-La Roche Inc.

US Patent


Assay Description
Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore, w...


US Patent US10428108 (2019)


BindingDB Entry DOI: 10.7270/Q2JQ13DT
More data for this
Ligand-Target Pair
Serine protease HTRA1


(Homo sapiens (Human))
BDBM415637
PNG
(US10428108, Example 48)
Show SMILES CC(C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)\C=C\c1ccc(Cl)c(Cl)c1)C(=O)C(F)(F)C(=O)NCC(F)(F)F
Show InChI InChI=1S/C27H26Cl2F5N3O4/c1-15(2)22(23(39)27(33,34)25(41)35-14-26(30,31)32)37-24(40)20(13-16-6-4-3-5-7-16)36-21(38)11-9-17-8-10-18(28)19(29)12-17/h3-12,15,20,22H,13-14H2,1-2H3,(H,35,41)(H,36,38)(H,37,40)/b11-9+/t20-,22-/m0/s1
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Hoffmann-La Roche Inc.

US Patent


Assay Description
Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore, w...


US Patent US10428108 (2019)


BindingDB Entry DOI: 10.7270/Q2JQ13DT
More data for this
Ligand-Target Pair
Serine protease HTRA1


(Homo sapiens (Human))
BDBM415650
PNG
(US10428108, Example 60)
Show SMILES CC(C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CC(c1ccccc1)c1ccc(Br)cc1)C(=O)C(F)(F)C(=O)NCC(F)(F)F
Show InChI InChI=1S/C33H33BrF5N3O4/c1-20(2)28(29(44)33(38,39)31(46)40-19-32(35,36)37)42-30(45)26(17-21-9-5-3-6-10-21)41-27(43)18-25(22-11-7-4-8-12-22)23-13-15-24(34)16-14-23/h3-16,20,25-26,28H,17-19H2,1-2H3,(H,40,46)(H,41,43)(H,42,45)/t25?,26-,28-/m0/s1
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Hoffmann-La Roche Inc.

US Patent


Assay Description
Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore, w...


US Patent US10428108 (2019)


BindingDB Entry DOI: 10.7270/Q2JQ13DT
More data for this
Ligand-Target Pair
Serine protease HTRA1


(Homo sapiens (Human))
BDBM415686
PNG
(US10428108, Example 95)
Show SMILES CC(C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CSc1cc(Cl)cc(Cl)c1)C(=O)C(F)(F)C(=O)NCC(F)(F)F
Show InChI InChI=1S/C26H26Cl2F5N3O4S/c1-14(2)21(22(38)26(32,33)24(40)34-13-25(29,30)31)36-23(39)19(8-15-6-4-3-5-7-15)35-20(37)12-41-18-10-16(27)9-17(28)11-18/h3-7,9-11,14,19,21H,8,12-13H2,1-2H3,(H,34,40)(H,35,37)(H,36,39)/t19-,21-/m0/s1
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Hoffmann-La Roche Inc.

US Patent


Assay Description
Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore, w...


US Patent US10428108 (2019)


BindingDB Entry DOI: 10.7270/Q2JQ13DT
More data for this
Ligand-Target Pair
Serine protease HTRA1


(Homo sapiens (Human))
BDBM415651
PNG
(US10428108, Example 61)
Show SMILES CC(C)[C@H](NC(=O)[C@H](Cc1ccc(Cl)cc1)NC(=O)CC(c1ccccc1)c1ccc(Br)cc1)C(=O)C(F)(F)C(=O)NCC(F)(F)F
Show InChI InChI=1S/C33H32BrClF5N3O4/c1-19(2)28(29(45)33(39,40)31(47)41-18-32(36,37)38)43-30(46)26(16-20-8-14-24(35)15-9-20)42-27(44)17-25(21-6-4-3-5-7-21)22-10-12-23(34)13-11-22/h3-15,19,25-26,28H,16-18H2,1-2H3,(H,41,47)(H,42,44)(H,43,46)/t25?,26-,28-/m0/s1
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Hoffmann-La Roche Inc.

US Patent


Assay Description
Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore, w...


US Patent US10428108 (2019)


BindingDB Entry DOI: 10.7270/Q2JQ13DT
More data for this
Ligand-Target Pair
Serine protease HTRA1


(Homo sapiens (Human))
BDBM415658
PNG
(US10428108, Example 68)
Show SMILES CC(C)[C@H](NC(=O)[C@@H](NC(=O)\C=C\c1cccc(Cl)c1)c1ccc(Cl)cc1)C(=O)C(F)(F)C(=O)NCC(F)(F)F
Show InChI InChI=1S/C26H24Cl2F5N3O4/c1-14(2)20(22(38)26(32,33)24(40)34-13-25(29,30)31)36-23(39)21(16-7-9-17(27)10-8-16)35-19(37)11-6-15-4-3-5-18(28)12-15/h3-12,14,20-21H,13H2,1-2H3,(H,34,40)(H,35,37)(H,36,39)/b11-6+/t20-,21-/m0/s1
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Hoffmann-La Roche Inc.

US Patent


Assay Description
Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore, w...


US Patent US10428108 (2019)


BindingDB Entry DOI: 10.7270/Q2JQ13DT
More data for this
Ligand-Target Pair
Serine protease HTRA1


(Homo sapiens (Human))
BDBM415640
PNG
(US10428108, Example 51)
Show SMILES CC(C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CC(c1ccccc1)c1ccccc1)C(=O)C(F)(F)C(=O)NCC(F)(F)F
Show InChI InChI=1S/C33H34F5N3O4/c1-21(2)28(29(43)33(37,38)31(45)39-20-32(34,35)36)41-30(44)26(18-22-12-6-3-7-13-22)40-27(42)19-25(23-14-8-4-9-15-23)24-16-10-5-11-17-24/h3-17,21,25-26,28H,18-20H2,1-2H3,(H,39,45)(H,40,42)(H,41,44)/t26-,28-/m0/s1
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Hoffmann-La Roche Inc.

US Patent


Assay Description
Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore, w...


US Patent US10428108 (2019)


BindingDB Entry DOI: 10.7270/Q2JQ13DT
More data for this
Ligand-Target Pair
Serine protease HTRA1


(Homo sapiens (Human))
BDBM415614
PNG
(US10428108, Example 25)
Show SMILES COc1ccc(C[C@H](NC(=O)CCc2ccc(Cl)c(Cl)c2)C(=O)N[C@@H](C(C)C)C(=O)C(F)(F)C(=O)NCC(F)(F)F)cc1OC
Show InChI InChI=1S/C29H32Cl2F5N3O6/c1-15(2)24(25(41)29(35,36)27(43)37-14-28(32,33)34)39-26(42)20(12-17-6-9-21(44-3)22(13-17)45-4)38-23(40)10-7-16-5-8-18(30)19(31)11-16/h5-6,8-9,11,13,15,20,24H,7,10,12,14H2,1-4H3,(H,37,43)(H,38,40)(H,39,42)/t20-,24-/m0/s1
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Hoffmann-La Roche Inc.

US Patent


Assay Description
Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore, w...


US Patent US10428108 (2019)


BindingDB Entry DOI: 10.7270/Q2JQ13DT
More data for this
Ligand-Target Pair
Serine protease HTRA1


(Homo sapiens (Human))
BDBM415632
PNG
(US10428108, Example 43)
Show SMILES CC(C)[C@H](NC(=O)[C@H](Cc1ccc(F)c(F)c1)NC(=O)COc1cc(Cl)cc(Cl)c1)C(=O)C(F)(F)C(=O)NCC(F)(F)F
Show InChI InChI=1S/C26H24Cl2F7N3O5/c1-12(2)21(22(40)26(34,35)24(42)36-11-25(31,32)33)38-23(41)19(6-13-3-4-17(29)18(30)5-13)37-20(39)10-43-16-8-14(27)7-15(28)9-16/h3-5,7-9,12,19,21H,6,10-11H2,1-2H3,(H,36,42)(H,37,39)(H,38,41)/t19-,21-/m0/s1
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Hoffmann-La Roche Inc.

US Patent


Assay Description
Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore, w...


US Patent US10428108 (2019)


BindingDB Entry DOI: 10.7270/Q2JQ13DT
More data for this
Ligand-Target Pair
Serine protease HTRA1


(Homo sapiens (Human))
BDBM415615
PNG
(US10428108, Example 26)
Show SMILES CC(C)[C@H](NC(=O)[C@H](Cc1ccc(Cl)c(Cl)c1)NC(=O)CCc1ccc(Cl)c(Cl)c1)C(=O)C(F)(F)C(=O)NCCc1ccccc1
Show InChI InChI=1S/C33H33Cl4F2N3O4/c1-19(2)29(30(44)33(38,39)32(46)40-15-14-20-6-4-3-5-7-20)42-31(45)27(18-22-9-12-24(35)26(37)17-22)41-28(43)13-10-21-8-11-23(34)25(36)16-21/h3-9,11-12,16-17,19,27,29H,10,13-15,18H2,1-2H3,(H,40,46)(H,41,43)(H,42,45)/t27-,29-/m0/s1
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Hoffmann-La Roche Inc.

US Patent


Assay Description
Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore, w...


US Patent US10428108 (2019)


BindingDB Entry DOI: 10.7270/Q2JQ13DT
More data for this
Ligand-Target Pair
Serine protease HTRA1


(Homo sapiens (Human))
BDBM415681
PNG
(US10428108, Example 90)
Show SMILES CC(C)[C@H](NC(=O)[C@@H](NC(=O)C[C@@H](Oc1cccc(Cl)c1)c1ccccc1)c1ccccc1)C(=O)C(F)(F)C(=O)NCC(F)(F)F
Show InChI InChI=1S/C32H31ClF5N3O5/c1-19(2)26(28(43)32(37,38)30(45)39-18-31(34,35)36)41-29(44)27(21-12-7-4-8-13-21)40-25(42)17-24(20-10-5-3-6-11-20)46-23-15-9-14-22(33)16-23/h3-16,19,24,26-27H,17-18H2,1-2H3,(H,39,45)(H,40,42)(H,41,44)/t24-,26+,27+/m1/s1
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Hoffmann-La Roche Inc.

US Patent


Assay Description
Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore, w...


US Patent US10428108 (2019)


BindingDB Entry DOI: 10.7270/Q2JQ13DT
More data for this
Ligand-Target Pair
Serine protease HTRA1


(Homo sapiens (Human))
BDBM415672
PNG
(US10428108, Example 82)
Show SMILES COc1ccc(C[C@H](NC(=O)CCc2ccc(Cl)c(Cl)c2)C(=O)N[C@@H](C(C)C)C(=O)C(F)(F)C(=O)NCC(F)(F)F)cc1
Show InChI InChI=1S/C28H30Cl2F5N3O5/c1-15(2)23(24(40)28(34,35)26(42)36-14-27(31,32)33)38-25(41)21(13-17-4-8-18(43-3)9-5-17)37-22(39)11-7-16-6-10-19(29)20(30)12-16/h4-6,8-10,12,15,21,23H,7,11,13-14H2,1-3H3,(H,36,42)(H,37,39)(H,38,41)/t21-,23-/m0/s1
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Hoffmann-La Roche Inc.

US Patent


Assay Description
Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore, w...


US Patent US10428108 (2019)


BindingDB Entry DOI: 10.7270/Q2JQ13DT
More data for this
Ligand-Target Pair
Serine protease HTRA1


(Homo sapiens (Human))
BDBM415620
PNG
(US10428108, Example 31)
Show SMILES CCNC(=O)C(F)(F)C(=O)[C@@H](NC(=O)[C@H](Cc1ccc(Cl)c(Cl)c1)NC(=O)COc1cc(Cl)cc(Cl)c1)C(C)C
Show InChI InChI=1S/C26H27Cl4F2N3O5/c1-4-33-25(39)26(31,32)23(37)22(13(2)3)35-24(38)20(8-14-5-6-18(29)19(30)7-14)34-21(36)12-40-17-10-15(27)9-16(28)11-17/h5-7,9-11,13,20,22H,4,8,12H2,1-3H3,(H,33,39)(H,34,36)(H,35,38)/t20-,22-/m0/s1
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Hoffmann-La Roche Inc.

US Patent


Assay Description
Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore, w...


US Patent US10428108 (2019)


BindingDB Entry DOI: 10.7270/Q2JQ13DT
More data for this
Ligand-Target Pair
Serine protease HTRA1


(Homo sapiens (Human))
BDBM415682
PNG
(US10428108, Example 91)
Show SMILES CC(C)[C@H](NC(=O)[C@@H](NC(=O)C[C@@H](Oc1cccc(Cl)c1)c1ccccc1)c1ccc(Cl)cc1)C(=O)C(F)(F)C(=O)NCC(F)(F)F
Show InChI InChI=1S/C32H30Cl2F5N3O5/c1-18(2)26(28(44)32(38,39)30(46)40-17-31(35,36)37)42-29(45)27(20-11-13-21(33)14-12-20)41-25(43)16-24(19-7-4-3-5-8-19)47-23-10-6-9-22(34)15-23/h3-15,18,24,26-27H,16-17H2,1-2H3,(H,40,46)(H,41,43)(H,42,45)/t24-,26+,27+/m1/s1
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Hoffmann-La Roche Inc.

US Patent


Assay Description
Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore, w...


US Patent US10428108 (2019)


BindingDB Entry DOI: 10.7270/Q2JQ13DT
More data for this
Ligand-Target Pair
Serine protease HTRA1


(Homo sapiens (Human))
BDBM415652
PNG
(US10428108, Example 62 | US10428108, Example 94)
Show SMILES CC(C)[C@H](NC(=O)[C@@H](NC(=O)\C=C\c1ccc(Cl)c(Cl)c1)c1ccccc1)C(=O)C(F)(F)C(=O)NCC(F)(F)F
Show InChI InChI=1S/C26H24Cl2F5N3O4/c1-14(2)20(22(38)26(32,33)24(40)34-13-25(29,30)31)36-23(39)21(16-6-4-3-5-7-16)35-19(37)11-9-15-8-10-17(27)18(28)12-15/h3-12,14,20-21H,13H2,1-2H3,(H,34,40)(H,35,37)(H,36,39)/b11-9+/t20-,21-/m0/s1
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Hoffmann-La Roche Inc.

US Patent


Assay Description
Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore, w...


US Patent US10428108 (2019)


BindingDB Entry DOI: 10.7270/Q2JQ13DT
More data for this
Ligand-Target Pair
Serine protease HTRA1


(Homo sapiens (Human))
BDBM415635
PNG
(US10428108, Example 46)
Show SMILES CCCNC(=O)C(F)(F)C(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)\C=C\c1ccc(Cl)c(Cl)c1)C(C)C
Show InChI InChI=1S/C28H31Cl2F2N3O4/c1-4-14-33-27(39)28(31,32)25(37)24(17(2)3)35-26(38)22(16-18-8-6-5-7-9-18)34-23(36)13-11-19-10-12-20(29)21(30)15-19/h5-13,15,17,22,24H,4,14,16H2,1-3H3,(H,33,39)(H,34,36)(H,35,38)/b13-11+/t22-,24-/m0/s1
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Hoffmann-La Roche Inc.

US Patent


Assay Description
Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore, w...


US Patent US10428108 (2019)


BindingDB Entry DOI: 10.7270/Q2JQ13DT
More data for this
Ligand-Target Pair
Serine protease HTRA1


(Homo sapiens (Human))
BDBM415613
PNG
(US10428108, Example 24)
Show SMILES COc1ccc(C[C@H](NC(=O)CCc2ccc(Cl)c(Cl)c2)C(=O)N[C@@H](C(C)C)C(=O)C(F)(F)C(=O)NCCc2ccccc2)cc1OC
Show InChI InChI=1S/C35H39Cl2F2N3O6/c1-21(2)31(32(44)35(38,39)34(46)40-17-16-22-8-6-5-7-9-22)42-33(45)27(19-24-11-14-28(47-3)29(20-24)48-4)41-30(43)15-12-23-10-13-25(36)26(37)18-23/h5-11,13-14,18,20-21,27,31H,12,15-17,19H2,1-4H3,(H,40,46)(H,41,43)(H,42,45)/t27-,31-/m0/s1
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Hoffmann-La Roche Inc.

US Patent


Assay Description
Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore, w...


US Patent US10428108 (2019)


BindingDB Entry DOI: 10.7270/Q2JQ13DT
More data for this
Ligand-Target Pair
Serine protease HTRA1


(Homo sapiens (Human))
BDBM415657
PNG
(US10428108, Example 67)
Show SMILES CC(C)[C@H](NC(=O)[C@@H](NC(=O)\C=C\c1cc(Cl)cc(Cl)c1)c1ccc(Cl)cc1)C(=O)C(F)(F)C(=O)NCC(F)(F)F
Show InChI InChI=1S/C26H23Cl3F5N3O4/c1-13(2)20(22(39)26(33,34)24(41)35-12-25(30,31)32)37-23(40)21(15-4-6-16(27)7-5-15)36-19(38)8-3-14-9-17(28)11-18(29)10-14/h3-11,13,20-21H,12H2,1-2H3,(H,35,41)(H,36,38)(H,37,40)/b8-3+/t20-,21-/m0/s1
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Hoffmann-La Roche Inc.

US Patent


Assay Description
Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore, w...


US Patent US10428108 (2019)


BindingDB Entry DOI: 10.7270/Q2JQ13DT
More data for this
Ligand-Target Pair
Serine protease HTRA1


(Homo sapiens (Human))
BDBM415627
PNG
(US10428108, Example 38)
Show SMILES CCCNC(=O)C(F)(F)C(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)COc1cc(Cl)cc(Cl)c1)C(C)C
Show InChI InChI=1S/C27H31Cl2F2N3O5/c1-4-10-32-26(38)27(30,31)24(36)23(16(2)3)34-25(37)21(11-17-8-6-5-7-9-17)33-22(35)15-39-20-13-18(28)12-19(29)14-20/h5-9,12-14,16,21,23H,4,10-11,15H2,1-3H3,(H,32,38)(H,33,35)(H,34,37)/t21-,23-/m0/s1
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Hoffmann-La Roche Inc.

US Patent


Assay Description
Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore, w...


US Patent US10428108 (2019)


BindingDB Entry DOI: 10.7270/Q2JQ13DT
More data for this
Ligand-Target Pair
Serine protease HTRA1


(Homo sapiens (Human))
BDBM415593
PNG
(US10428108, Example 5)
Show SMILES CC(C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CCc1ccc(Cl)c(Cl)c1)C(=O)C(F)(F)C(=O)NCC(F)(F)F
Show InChI InChI=1S/C27H28Cl2F5N3O4/c1-15(2)22(23(39)27(33,34)25(41)35-14-26(30,31)32)37-24(40)20(13-16-6-4-3-5-7-16)36-21(38)11-9-17-8-10-18(28)19(29)12-17/h3-8,10,12,15,20,22H,9,11,13-14H2,1-2H3,(H,35,41)(H,36,38)(H,37,40)/t20-,22-/m0/s1
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Hoffmann-La Roche Inc.

US Patent


Assay Description
Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore, w...


US Patent US10428108 (2019)


BindingDB Entry DOI: 10.7270/Q2JQ13DT
More data for this
Ligand-Target Pair
Serine protease HTRA1


(Homo sapiens (Human))
BDBM415634
PNG
(US10428108, Example 45)
Show SMILES COc1ccc(cc1)C(CC(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](C(C)C)C(=O)C(F)(F)C(=O)NCC(F)(F)F)c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C34H34Cl2F5N3O5/c1-19(2)29(30(46)34(40,41)32(48)42-18-33(37,38)39)44-31(47)27(15-20-7-5-4-6-8-20)43-28(45)17-24(21-9-12-23(49-3)13-10-21)22-11-14-25(35)26(36)16-22/h4-14,16,19,24,27,29H,15,17-18H2,1-3H3,(H,42,48)(H,43,45)(H,44,47)/t24?,27-,29-/m0/s1
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Hoffmann-La Roche Inc.

US Patent


Assay Description
Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore, w...


US Patent US10428108 (2019)


BindingDB Entry DOI: 10.7270/Q2JQ13DT
More data for this
Ligand-Target Pair
Serine protease HTRA1


(Homo sapiens (Human))
BDBM415626
PNG
(US10428108, Example 37)
Show SMILES COc1ccc(C[C@H](NC(=O)COc2cc(Cl)cc(Cl)c2)C(=O)N[C@@H](C(C)C)C(=O)C(F)(F)C(=O)NCCC(F)(F)F)cc1OC
Show InChI InChI=1S/C29H32Cl2F5N3O7/c1-15(2)24(25(41)29(35,36)27(43)37-8-7-28(32,33)34)39-26(42)20(9-16-5-6-21(44-3)22(10-16)45-4)38-23(40)14-46-19-12-17(30)11-18(31)13-19/h5-6,10-13,15,20,24H,7-9,14H2,1-4H3,(H,37,43)(H,38,40)(H,39,42)/t20-,24-/m0/s1
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Hoffmann-La Roche Inc.

US Patent


Assay Description
Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore, w...


US Patent US10428108 (2019)


BindingDB Entry DOI: 10.7270/Q2JQ13DT
More data for this
Ligand-Target Pair
Serine protease HTRA1


(Homo sapiens (Human))
BDBM415596
PNG
(US10428108, Example 8)
Show SMILES CC(C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CCc1cc(Cl)cc(Cl)c1)C(=O)C(F)(F)C(=O)NCC(F)(F)F
Show InChI InChI=1S/C27H28Cl2F5N3O4/c1-15(2)22(23(39)27(33,34)25(41)35-14-26(30,31)32)37-24(40)20(12-16-6-4-3-5-7-16)36-21(38)9-8-17-10-18(28)13-19(29)11-17/h3-7,10-11,13,15,20,22H,8-9,12,14H2,1-2H3,(H,35,41)(H,36,38)(H,37,40)/t20-,22-/m0/s1
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Hoffmann-La Roche Inc.

US Patent


Assay Description
Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore, w...


US Patent US10428108 (2019)


BindingDB Entry DOI: 10.7270/Q2JQ13DT
More data for this
Ligand-Target Pair
Serine protease HTRA1


(Homo sapiens (Human))
BDBM415595
PNG
(US10428108, Example 7)
Show SMILES CC(C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)COc1ccc(Cl)c(Cl)c1)C(=O)C(F)(F)C(=O)NCC(F)(F)F
Show InChI InChI=1S/C26H26Cl2F5N3O5/c1-14(2)21(22(38)26(32,33)24(40)34-13-25(29,30)31)36-23(39)19(10-15-6-4-3-5-7-15)35-20(37)12-41-16-8-9-17(27)18(28)11-16/h3-9,11,14,19,21H,10,12-13H2,1-2H3,(H,34,40)(H,35,37)(H,36,39)/t19-,21-/m0/s1
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Hoffmann-La Roche Inc.

US Patent


Assay Description
Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore, w...


US Patent US10428108 (2019)


BindingDB Entry DOI: 10.7270/Q2JQ13DT
More data for this
Ligand-Target Pair
Serine protease HTRA1


(Homo sapiens (Human))
BDBM415633
PNG
(US10428108, Example 44)
Show SMILES COc1ccc(C[C@H](NC(=O)COc2cc(Cl)cc(Cl)c2)C(=O)N[C@@H](C(C)C)C(=O)C(F)(F)C(=O)NCC(F)(F)F)cc1OC
Show InChI InChI=1S/C28H30Cl2F5N3O7/c1-14(2)23(24(40)28(34,35)26(42)36-13-27(31,32)33)38-25(41)19(7-15-5-6-20(43-3)21(8-15)44-4)37-22(39)12-45-18-10-16(29)9-17(30)11-18/h5-6,8-11,14,19,23H,7,12-13H2,1-4H3,(H,36,42)(H,37,39)(H,38,41)/t19-,23-/m0/s1
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Hoffmann-La Roche Inc.

US Patent


Assay Description
Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore, w...


US Patent US10428108 (2019)


BindingDB Entry DOI: 10.7270/Q2JQ13DT
More data for this
Ligand-Target Pair
Serine protease HTRA1


(Homo sapiens (Human))
BDBM415601
PNG
(US10428108, Example 13)
Show SMILES CC(C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)COc1cc(Cl)cc(Cl)c1)C(=O)C(F)(F)C(=O)NCCN1CCOCC1
Show InChI InChI=1S/C30H36Cl2F2N4O6/c1-19(2)26(27(40)30(33,34)29(42)35-8-9-38-10-12-43-13-11-38)37-28(41)24(14-20-6-4-3-5-7-20)36-25(39)18-44-23-16-21(31)15-22(32)17-23/h3-7,15-17,19,24,26H,8-14,18H2,1-2H3,(H,35,42)(H,36,39)(H,37,41)/t24-,26-/m0/s1
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Hoffmann-La Roche Inc.

US Patent


Assay Description
Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore, w...


US Patent US10428108 (2019)


BindingDB Entry DOI: 10.7270/Q2JQ13DT
More data for this
Ligand-Target Pair
Serine protease HTRA1


(Homo sapiens (Human))
BDBM415608
PNG
(US10428108, Example 19)
Show SMILES CC(C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)COc1cc(Cl)cc(Cl)c1)C(=O)C(F)(F)C(=O)NCCC(F)(F)F
Show InChI InChI=1S/C27H28Cl2F5N3O5/c1-15(2)22(23(39)27(33,34)25(41)35-9-8-26(30,31)32)37-24(40)20(10-16-6-4-3-5-7-16)36-21(38)14-42-19-12-17(28)11-18(29)13-19/h3-7,11-13,15,20,22H,8-10,14H2,1-2H3,(H,35,41)(H,36,38)(H,37,40)/t20-,22-/m0/s1
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Hoffmann-La Roche Inc.

US Patent


Assay Description
Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore, w...


US Patent US10428108 (2019)


BindingDB Entry DOI: 10.7270/Q2JQ13DT
More data for this
Ligand-Target Pair
Serine protease HTRA1


(Homo sapiens (Human))
BDBM415594
PNG
(US10428108, Example 6)
Show SMILES CC(C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)COc1cccc(Cl)c1)C(=O)C(F)(F)C(=O)NCC(F)(F)F
Show InChI InChI=1S/C26H27ClF5N3O5/c1-15(2)21(22(37)26(31,32)24(39)33-14-25(28,29)30)35-23(38)19(11-16-7-4-3-5-8-16)34-20(36)13-40-18-10-6-9-17(27)12-18/h3-10,12,15,19,21H,11,13-14H2,1-2H3,(H,33,39)(H,34,36)(H,35,38)/t19-,21-/m0/s1
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Hoffmann-La Roche Inc.

US Patent


Assay Description
Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore, w...


US Patent US10428108 (2019)


BindingDB Entry DOI: 10.7270/Q2JQ13DT
More data for this
Ligand-Target Pair
Serine protease HTRA1


(Homo sapiens (Human))
BDBM415625
PNG
(US10428108, Example 36)
Show SMILES CC(C)[C@H](NC(=O)[C@H](Cc1ccc(F)c(F)c1)NC(=O)COc1cc(Cl)cc(Cl)c1)C(=O)C(F)(F)C(=O)NCCC(F)(F)F
Show InChI InChI=1S/C27H26Cl2F7N3O5/c1-13(2)22(23(41)27(35,36)25(43)37-6-5-26(32,33)34)39-24(42)20(8-14-3-4-18(30)19(31)7-14)38-21(40)12-44-17-10-15(28)9-16(29)11-17/h3-4,7,9-11,13,20,22H,5-6,8,12H2,1-2H3,(H,37,43)(H,38,40)(H,39,42)/t20-,22-/m0/s1
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Hoffmann-La Roche Inc.

US Patent


Assay Description
Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore, w...


US Patent US10428108 (2019)


BindingDB Entry DOI: 10.7270/Q2JQ13DT
More data for this
Ligand-Target Pair
Serine protease HTRA1


(Homo sapiens (Human))
BDBM415624
PNG
(US10428108, Example 35)
Show SMILES CC(C)[C@H](NC(=O)[C@H](Cc1ccc(Cl)c(Cl)c1)NC(=O)COc1cc(Cl)cc(Cl)c1)C(=O)C(F)(F)C(=O)NCCC(F)(F)F
Show InChI InChI=1S/C27H26Cl4F5N3O5/c1-13(2)22(23(41)27(35,36)25(43)37-6-5-26(32,33)34)39-24(42)20(8-14-3-4-18(30)19(31)7-14)38-21(40)12-44-17-10-15(28)9-16(29)11-17/h3-4,7,9-11,13,20,22H,5-6,8,12H2,1-2H3,(H,37,43)(H,38,40)(H,39,42)/t20-,22-/m0/s1
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Hoffmann-La Roche Inc.

US Patent


Assay Description
Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore, w...


US Patent US10428108 (2019)


BindingDB Entry DOI: 10.7270/Q2JQ13DT
More data for this
Ligand-Target Pair
Serine protease HTRA1


(Homo sapiens (Human))
BDBM415598
PNG
(US10428108, Example 10)
Show SMILES CC(C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CCc1cccc(Cl)c1)C(=O)C(F)(F)C(=O)NCC(F)(F)F
Show InChI InChI=1S/C27H29ClF5N3O4/c1-16(2)22(23(38)27(32,33)25(40)34-15-26(29,30)31)36-24(39)20(14-17-7-4-3-5-8-17)35-21(37)12-11-18-9-6-10-19(28)13-18/h3-10,13,16,20,22H,11-12,14-15H2,1-2H3,(H,34,40)(H,35,37)(H,36,39)/t20-,22-/m0/s1
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Hoffmann-La Roche Inc.

US Patent


Assay Description
Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore, w...


US Patent US10428108 (2019)


BindingDB Entry DOI: 10.7270/Q2JQ13DT
More data for this
Ligand-Target Pair
Serine protease HTRA1


(Homo sapiens (Human))
BDBM415612
PNG
(US10428108, Example 23)
Show SMILES CC(C)[C@H](NC(=O)[C@H](Cc1ccc(Cl)cc1)NC(=O)CCc1ccc(Cl)c(Cl)c1)C(=O)C(F)(F)C(=O)NCCc1ccccc1
Show InChI InChI=1S/C33H34Cl3F2N3O4/c1-20(2)29(30(43)33(37,38)32(45)39-17-16-21-6-4-3-5-7-21)41-31(44)27(19-23-8-12-24(34)13-9-23)40-28(42)15-11-22-10-14-25(35)26(36)18-22/h3-10,12-14,18,20,27,29H,11,15-17,19H2,1-2H3,(H,39,45)(H,40,42)(H,41,44)/t27-,29-/m0/s1
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Hoffmann-La Roche Inc.

US Patent


Assay Description
Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore, w...


US Patent US10428108 (2019)


BindingDB Entry DOI: 10.7270/Q2JQ13DT
More data for this
Ligand-Target Pair
Serine protease HTRA1


(Homo sapiens (Human))
BDBM415599
PNG
(US10428108, Example 11)
Show SMILES CC(C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)COc1ccc(Cl)c(Cl)c1)C(=O)C(F)(F)C(=O)NCCN1CCOCC1
Show InChI InChI=1S/C30H36Cl2F2N4O6/c1-19(2)26(27(40)30(33,34)29(42)35-10-11-38-12-14-43-15-13-38)37-28(41)24(16-20-6-4-3-5-7-20)36-25(39)18-44-21-8-9-22(31)23(32)17-21/h3-9,17,19,24,26H,10-16,18H2,1-2H3,(H,35,42)(H,36,39)(H,37,41)/t24-,26-/m0/s1
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Hoffmann-La Roche Inc.

US Patent


Assay Description
Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore, w...


US Patent US10428108 (2019)


BindingDB Entry DOI: 10.7270/Q2JQ13DT
More data for this
Ligand-Target Pair
Serine protease HTRA1


(Homo sapiens (Human))
BDBM415623
PNG
(US10428108, Example 34)
Show SMILES CC(C)[C@H](NC(=O)[C@H](Cc1ccc(Cl)cc1)NC(=O)COc1cc(Cl)cc(Cl)c1)C(=O)C(F)(F)C(=O)NCCC(F)(F)F
Show InChI InChI=1S/C27H27Cl3F5N3O5/c1-14(2)22(23(40)27(34,35)25(42)36-8-7-26(31,32)33)38-24(41)20(9-15-3-5-16(28)6-4-15)37-21(39)13-43-19-11-17(29)10-18(30)12-19/h3-6,10-12,14,20,22H,7-9,13H2,1-2H3,(H,36,42)(H,37,39)(H,38,41)/t20-,22-/m0/s1
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Hoffmann-La Roche Inc.

US Patent


Assay Description
Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore, w...


US Patent US10428108 (2019)


BindingDB Entry DOI: 10.7270/Q2JQ13DT
More data for this
Ligand-Target Pair
Serine protease HTRA1


(Homo sapiens (Human))
BDBM415619
PNG
(US10428108, Example 30)
Show SMILES CC(C)CNC(=O)C(F)(F)C(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)COc1cc(Cl)cc(Cl)c1)C(C)C
Show InChI InChI=1S/C28H33Cl2F2N3O5/c1-16(2)14-33-27(39)28(31,32)25(37)24(17(3)4)35-26(38)22(10-18-8-6-5-7-9-18)34-23(36)15-40-21-12-19(29)11-20(30)13-21/h5-9,11-13,16-17,22,24H,10,14-15H2,1-4H3,(H,33,39)(H,34,36)(H,35,38)/t22-,24-/m0/s1
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Hoffmann-La Roche Inc.

US Patent


Assay Description
Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore, w...


US Patent US10428108 (2019)


BindingDB Entry DOI: 10.7270/Q2JQ13DT
More data for this
Ligand-Target Pair
Serine protease HTRA1


(Homo sapiens (Human))
BDBM415621
PNG
(US10428108, Example 32)
Show SMILES CC(C)CNC(=O)C(F)(F)C(=O)[C@@H](NC(=O)[C@H](Cc1ccc(Cl)c(Cl)c1)NC(=O)COc1cc(Cl)cc(Cl)c1)C(C)C
Show InChI InChI=1S/C28H31Cl4F2N3O5/c1-14(2)12-35-27(41)28(33,34)25(39)24(15(3)4)37-26(40)22(8-16-5-6-20(31)21(32)7-16)36-23(38)13-42-19-10-17(29)9-18(30)11-19/h5-7,9-11,14-15,22,24H,8,12-13H2,1-4H3,(H,35,41)(H,36,38)(H,37,40)/t22-,24-/m0/s1
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Hoffmann-La Roche Inc.

US Patent


Assay Description
Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore, w...


US Patent US10428108 (2019)


BindingDB Entry DOI: 10.7270/Q2JQ13DT
More data for this
Ligand-Target Pair
Serine protease HTRA1


(Homo sapiens (Human))
BDBM415607
PNG
(US10428108, Example 18)
Show SMILES CC(C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CCc1ccc(Cl)c(Cl)c1)C(=O)C(F)(F)C(=O)NCCC(F)(F)F
Show InChI InChI=1S/C28H30Cl2F5N3O4/c1-16(2)23(24(40)28(34,35)26(42)36-13-12-27(31,32)33)38-25(41)21(15-17-6-4-3-5-7-17)37-22(39)11-9-18-8-10-19(29)20(30)14-18/h3-8,10,14,16,21,23H,9,11-13,15H2,1-2H3,(H,36,42)(H,37,39)(H,38,41)/t21-,23-/m0/s1
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Hoffmann-La Roche Inc.

US Patent


Assay Description
Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore, w...


US Patent US10428108 (2019)


BindingDB Entry DOI: 10.7270/Q2JQ13DT
More data for this
Ligand-Target Pair
Serine protease HTRA1


(Homo sapiens (Human))
BDBM415609
PNG
(US10428108, Example 20)
Show SMILES CC(C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)COc1cccc(Cl)c1)C(=O)C(F)(F)C(=O)NCCC(F)(F)F
Show InChI InChI=1S/C27H29ClF5N3O5/c1-16(2)22(23(38)27(32,33)25(40)34-12-11-26(29,30)31)36-24(39)20(13-17-7-4-3-5-8-17)35-21(37)15-41-19-10-6-9-18(28)14-19/h3-10,14,16,20,22H,11-13,15H2,1-2H3,(H,34,40)(H,35,37)(H,36,39)/t20-,22-/m0/s1
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Hoffmann-La Roche Inc.

US Patent


Assay Description
Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore, w...


US Patent US10428108 (2019)


BindingDB Entry DOI: 10.7270/Q2JQ13DT
More data for this
Ligand-Target Pair
Serine protease HTRA1


(Homo sapiens (Human))
BDBM415610
PNG
(US10428108, Example 21)
Show SMILES CC(C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CCc1cc(Cl)cc(Cl)c1)C(=O)C(F)(F)C(=O)NCCC(F)(F)F
Show InChI InChI=1S/C28H30Cl2F5N3O4/c1-16(2)23(24(40)28(34,35)26(42)36-11-10-27(31,32)33)38-25(41)21(14-17-6-4-3-5-7-17)37-22(39)9-8-18-12-19(29)15-20(30)13-18/h3-7,12-13,15-16,21,23H,8-11,14H2,1-2H3,(H,36,42)(H,37,39)(H,38,41)/t21-,23-/m0/s1
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Hoffmann-La Roche Inc.

US Patent


Assay Description
Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore, w...


US Patent US10428108 (2019)


BindingDB Entry DOI: 10.7270/Q2JQ13DT
More data for this
Ligand-Target Pair
Serine protease HTRA1


(Homo sapiens (Human))
BDBM415618
PNG
(US10428108, Example 29)
Show SMILES CCNC(=O)C(F)(F)C(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)COc1cc(Cl)cc(Cl)c1)C(C)C
Show InChI InChI=1S/C26H29Cl2F2N3O5/c1-4-31-25(37)26(29,30)23(35)22(15(2)3)33-24(36)20(10-16-8-6-5-7-9-16)32-21(34)14-38-19-12-17(27)11-18(28)13-19/h5-9,11-13,15,20,22H,4,10,14H2,1-3H3,(H,31,37)(H,32,34)(H,33,36)/t20-,22-/m0/s1
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Hoffmann-La Roche Inc.

US Patent


Assay Description
Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore, w...


US Patent US10428108 (2019)


BindingDB Entry DOI: 10.7270/Q2JQ13DT
More data for this
Ligand-Target Pair
Serine protease HTRA1


(Homo sapiens (Human))
BDBM415622
PNG
(US10428108, Example 33)
Show SMILES CC(C)CNC(=O)C(F)(F)C(=O)[C@@H](NC(=O)[C@H](Cc1ccc(F)c(F)c1)NC(=O)COc1cc(Cl)cc(Cl)c1)C(C)C
Show InChI InChI=1S/C28H31Cl2F4N3O5/c1-14(2)12-35-27(41)28(33,34)25(39)24(15(3)4)37-26(40)22(8-16-5-6-20(31)21(32)7-16)36-23(38)13-42-19-10-17(29)9-18(30)11-19/h5-7,9-11,14-15,22,24H,8,12-13H2,1-4H3,(H,35,41)(H,36,38)(H,37,40)/t22-,24-/m0/s1
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n/an/a 370n/an/an/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore, w...


US Patent US10428108 (2019)


BindingDB Entry DOI: 10.7270/Q2JQ13DT
More data for this
Ligand-Target Pair
Serine protease HTRA1


(Homo sapiens (Human))
BDBM415606
PNG
(US10428108, Example 17)
Show SMILES CC(C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)COc1cccc(Cl)c1)C(=O)C(F)(F)C(=O)NCCc1ccccc1
Show InChI InChI=1S/C32H34ClF2N3O5/c1-21(2)28(29(40)32(34,35)31(42)36-17-16-22-10-5-3-6-11-22)38-30(41)26(18-23-12-7-4-8-13-23)37-27(39)20-43-25-15-9-14-24(33)19-25/h3-15,19,21,26,28H,16-18,20H2,1-2H3,(H,36,42)(H,37,39)(H,38,41)/t26-,28-/m0/s1
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n/an/a 390n/an/an/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore, w...


US Patent US10428108 (2019)


BindingDB Entry DOI: 10.7270/Q2JQ13DT
More data for this
Ligand-Target Pair
Serine protease HTRA1


(Homo sapiens (Human))
BDBM415600
PNG
(US10428108, Example 12)
Show SMILES CC(C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)COc1cccc(Cl)c1)C(=O)C(F)(F)C(=O)NCCN1CCOCC1
Show InChI InChI=1S/C30H37ClF2N4O6/c1-20(2)26(27(39)30(32,33)29(41)34-11-12-37-13-15-42-16-14-37)36-28(40)24(17-21-7-4-3-5-8-21)35-25(38)19-43-23-10-6-9-22(31)18-23/h3-10,18,20,24,26H,11-17,19H2,1-2H3,(H,34,41)(H,35,38)(H,36,40)/t24-,26-/m0/s1
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n/an/a 400n/an/an/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore, w...


US Patent US10428108 (2019)


BindingDB Entry DOI: 10.7270/Q2JQ13DT
More data for this
Ligand-Target Pair
Serine protease HTRA1


(Homo sapiens (Human))
BDBM415605
PNG
(US10428108, Example 16)
Show SMILES CC(C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CCc1ccc(Cl)c(Cl)c1)C(=O)C(F)(F)C(=O)NCCc1ccccc1
Show InChI InChI=1S/C33H35Cl2F2N3O4/c1-21(2)29(30(42)33(36,37)32(44)38-18-17-22-9-5-3-6-10-22)40-31(43)27(20-23-11-7-4-8-12-23)39-28(41)16-14-24-13-15-25(34)26(35)19-24/h3-13,15,19,21,27,29H,14,16-18,20H2,1-2H3,(H,38,44)(H,39,41)(H,40,43)/t27-,29-/m0/s1
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n/an/a 410n/an/an/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore, w...


US Patent US10428108 (2019)


BindingDB Entry DOI: 10.7270/Q2JQ13DT
More data for this
Ligand-Target Pair
Serine protease HTRA1


(Homo sapiens (Human))
BDBM415592
PNG
(US10428108, Example 4)
Show SMILES CC(C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CCc1cccc(Cl)c1)C(=O)C(F)(F)C(=O)NCCC(F)(F)F
Show InChI InChI=1S/C28H31ClF5N3O4/c1-17(2)23(24(39)28(33,34)26(41)35-14-13-27(30,31)32)37-25(40)21(16-18-7-4-3-5-8-18)36-22(38)12-11-19-9-6-10-20(29)15-19/h3-10,15,17,21,23H,11-14,16H2,1-2H3,(H,35,41)(H,36,38)(H,37,40)/t21-,23-/m0/s1
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n/an/a 420n/an/an/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore, w...


US Patent US10428108 (2019)


BindingDB Entry DOI: 10.7270/Q2JQ13DT
More data for this
Ligand-Target Pair
Serine protease HTRA1


(Homo sapiens (Human))
BDBM415628
PNG
(US10428108, Example 39)
Show SMILES CC(C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)COc1cc(Cl)cc(Cl)c1)C(=O)C(F)(F)C(=O)NCC(C)(C)C
Show InChI InChI=1S/C29H35Cl2F2N3O5/c1-17(2)24(25(38)29(32,33)27(40)34-16-28(3,4)5)36-26(39)22(11-18-9-7-6-8-10-18)35-23(37)15-41-21-13-19(30)12-20(31)14-21/h6-10,12-14,17,22,24H,11,15-16H2,1-5H3,(H,34,40)(H,35,37)(H,36,39)/t22-,24-/m0/s1
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n/an/a 430n/an/an/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore, w...


US Patent US10428108 (2019)


BindingDB Entry DOI: 10.7270/Q2JQ13DT
More data for this
Ligand-Target Pair
Serine protease HTRA1


(Homo sapiens (Human))
BDBM415636
PNG
(US10428108, Example 47)
Show SMILES CC(C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)\C=C\c1ccc(Cl)c(Cl)c1)C(=O)C(F)(F)C(=O)NCC(C)(C)C
Show InChI InChI=1S/C30H35Cl2F2N3O4/c1-18(2)25(26(39)30(33,34)28(41)35-17-29(3,4)5)37-27(40)23(16-19-9-7-6-8-10-19)36-24(38)14-12-20-11-13-21(31)22(32)15-20/h6-15,18,23,25H,16-17H2,1-5H3,(H,35,41)(H,36,38)(H,37,40)/b14-12+/t23-,25-/m0/s1
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n/an/a 440n/an/an/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore, w...


US Patent US10428108 (2019)


BindingDB Entry DOI: 10.7270/Q2JQ13DT
More data for this
Ligand-Target Pair
Serine protease HTRA1


(Homo sapiens (Human))
BDBM415611
PNG
(US10428108, Example 22)
Show SMILES CC(C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)COc1ccc(Cl)c(Cl)c1)C(=O)C(F)(F)C(=O)NCCC(F)(F)F
Show InChI InChI=1S/C27H28Cl2F5N3O5/c1-15(2)22(23(39)27(33,34)25(41)35-11-10-26(30,31)32)37-24(40)20(12-16-6-4-3-5-7-16)36-21(38)14-42-17-8-9-18(28)19(29)13-17/h3-9,13,15,20,22H,10-12,14H2,1-2H3,(H,35,41)(H,36,38)(H,37,40)/t20-,22-/m0/s1
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n/an/a 490n/an/an/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore, w...


US Patent US10428108 (2019)


BindingDB Entry DOI: 10.7270/Q2JQ13DT
More data for this
Ligand-Target Pair
Serine protease HTRA1


(Homo sapiens (Human))
BDBM415630
PNG
(US10428108, Example 41)
Show SMILES CCCNC(=O)C(F)(F)C(=O)[C@@H](NC(=O)[C@H](Cc1ccc(Cl)cc1)NC(=O)COc1cc(Cl)cc(Cl)c1)C(C)C
Show InChI InChI=1S/C27H30Cl3F2N3O5/c1-4-9-33-26(39)27(31,32)24(37)23(15(2)3)35-25(38)21(10-16-5-7-17(28)8-6-16)34-22(36)14-40-20-12-18(29)11-19(30)13-20/h5-8,11-13,15,21,23H,4,9-10,14H2,1-3H3,(H,33,39)(H,34,36)(H,35,38)/t21-,23-/m0/s1
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n/an/a 550n/an/an/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore, w...


US Patent US10428108 (2019)


BindingDB Entry DOI: 10.7270/Q2JQ13DT
More data for this
Ligand-Target Pair
Serine protease HTRA1


(Homo sapiens (Human))
BDBM415604
PNG
(US10428108, Example 15)
Show SMILES CC(C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CCc1ccc(Cl)c(Cl)c1)C(=O)C(F)(F)C(=O)NCCN1CCOCC1
Show InChI InChI=1S/C31H38Cl2F2N4O5/c1-20(2)27(28(41)31(34,35)30(43)36-12-13-39-14-16-44-17-15-39)38-29(42)25(19-21-6-4-3-5-7-21)37-26(40)11-9-22-8-10-23(32)24(33)18-22/h3-8,10,18,20,25,27H,9,11-17,19H2,1-2H3,(H,36,43)(H,37,40)(H,38,42)/t25-,27-/m0/s1
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n/an/a 630n/an/an/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore, w...


US Patent US10428108 (2019)


BindingDB Entry DOI: 10.7270/Q2JQ13DT
More data for this
Ligand-Target Pair
Serine protease HTRA1


(Homo sapiens (Human))
BDBM415591
PNG
(US10428108, Example 3)
Show SMILES CC(C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CCc1cccc(Cl)c1)C(=O)C(F)(F)C(=O)NCCc1ccccc1
Show InChI InChI=1S/C33H36ClF2N3O4/c1-22(2)29(30(41)33(35,36)32(43)37-19-18-23-10-5-3-6-11-23)39-31(42)27(21-24-12-7-4-8-13-24)38-28(40)17-16-25-14-9-15-26(34)20-25/h3-15,20,22,27,29H,16-19,21H2,1-2H3,(H,37,43)(H,38,40)(H,39,42)/t27-,29-/m0/s1
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n/an/a 890n/an/an/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore, w...


US Patent US10428108 (2019)


BindingDB Entry DOI: 10.7270/Q2JQ13DT
More data for this
Ligand-Target Pair
Serine protease HTRA1


(Homo sapiens (Human))
BDBM415589
PNG
((4S)-4-[[(2S)-2-[3-(3-Chlorophenyl)propanoylamino]...)
Show SMILES CC(C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CCc1cccc(Cl)c1)C(=O)C(F)(F)C(=O)NCCN1CCOCC1
Show InChI InChI=1S/C31H39ClF2N4O5/c1-21(2)27(28(40)31(33,34)30(42)35-13-14-38-15-17-43-18-16-38)37-29(41)25(20-22-7-4-3-5-8-22)36-26(39)12-11-23-9-6-10-24(32)19-23/h3-10,19,21,25,27H,11-18,20H2,1-2H3,(H,35,42)(H,36,39)(H,37,41)/t25-,27-/m0/s1
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n/an/a 1.37E+3n/an/an/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore, w...


US Patent US10428108 (2019)


BindingDB Entry DOI: 10.7270/Q2JQ13DT
More data for this
Ligand-Target Pair
Serine protease HTRA1


(Homo sapiens (Human))
BDBM415631
PNG
(US10428108, Example 42)
Show SMILES CC(C)[C@H](NC(=O)[C@H](Cc1ccc(F)c(F)c1)NC(=O)COc1cc(Cl)cc(Cl)c1)C(=O)C(F)(F)C(=O)NCC(C)(C)C
Show InChI InChI=1S/C29H33Cl2F4N3O5/c1-15(2)24(25(40)29(34,35)27(42)36-14-28(3,4)5)38-26(41)22(9-16-6-7-20(32)21(33)8-16)37-23(39)13-43-19-11-17(30)10-18(31)12-19/h6-8,10-12,15,22,24H,9,13-14H2,1-5H3,(H,36,42)(H,37,39)(H,38,41)/t22-,24-/m0/s1
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n/an/a 1.70E+3n/an/an/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore, w...


US Patent US10428108 (2019)


BindingDB Entry DOI: 10.7270/Q2JQ13DT
More data for this
Ligand-Target Pair
Serine protease HTRA1


(Homo sapiens (Human))
BDBM415603
PNG
(US10428108, Example 14)
Show SMILES CC(C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CCc1cc(Cl)cc(Cl)c1)C(=O)C(F)(F)C(=O)NCCN1CCOCC1
Show InChI InChI=1S/C31H38Cl2F2N4O5/c1-20(2)27(28(41)31(34,35)30(43)36-10-11-39-12-14-44-15-13-39)38-29(42)25(18-21-6-4-3-5-7-21)37-26(40)9-8-22-16-23(32)19-24(33)17-22/h3-7,16-17,19-20,25,27H,8-15,18H2,1-2H3,(H,36,43)(H,37,40)(H,38,42)/t25-,27-/m0/s1
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n/an/a 1.91E+3n/an/an/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore, w...


US Patent US10428108 (2019)


BindingDB Entry DOI: 10.7270/Q2JQ13DT
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%