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Patent code US10434101

Compile Data Set for Download or QSAR
Found 94 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Epidermal growth factor receptor(L858R, T790M)


(Homo sapiens (Human))
BDBM149434
PNG
(US10434101, Compound I-36 | US8975249, I-36)
Show SMILES FC(F)Oc1cc(ccc1Nc1ncc(Cl)c(Oc2cccc(NC(=O)C=C)c2)n1)N1CCOCC1
Show InChI InChI=1S/C24H22ClF2N5O4/c1-2-21(33)29-15-4-3-5-17(12-15)35-22-18(25)14-28-24(31-22)30-19-7-6-16(13-20(19)36-23(26)27)32-8-10-34-11-9-32/h2-7,12-14,23H,1,8-11H2,(H,29,33)(H,28,30,31)
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n/an/a<1n/an/an/an/an/an/a



Celgene CAR LLC

US Patent


Assay Description
Briefly, 10× stocks of EGFR-WT (PV3872) from Invitrogen and EGFR-T790M/L858R (40350) from BPS Bioscience, San Diego, Calif., 1.13×ATP (AS001A) and ap...


US Patent US10434101 (2019)


BindingDB Entry DOI: 10.7270/Q2NK3HD3
More data for this
Ligand-Target Pair
Epidermal growth factor receptor(L858R, T790M)


(Homo sapiens (Human))
BDBM149432
PNG
(US10434101, Compound I-34 | US8975249, I-34)
Show SMILES COc1cc(ccc1Nc1ncc(c(Nc2cccc(NC(=O)C=C)c2)n1)C(F)(F)F)N1CCN(CC1)C(=O)C(C)(C)C
Show InChI InChI=1S/C30H34F3N7O3/c1-6-25(41)35-19-8-7-9-20(16-19)36-26-22(30(31,32)33)18-34-28(38-26)37-23-11-10-21(17-24(23)43-5)39-12-14-40(15-13-39)27(42)29(2,3)4/h6-11,16-18H,1,12-15H2,2-5H3,(H,35,41)(H2,34,36,37,38)
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n/an/a<1n/an/an/an/an/an/a



Celgene CAR LLC

US Patent


Assay Description
Briefly, 10× stocks of EGFR-WT (PV3872) from Invitrogen and EGFR-T790M/L858R (40350) from BPS Bioscience, San Diego, Calif., 1.13×ATP (AS001A) and ap...


US Patent US10434101 (2019)


BindingDB Entry DOI: 10.7270/Q2NK3HD3
More data for this
Ligand-Target Pair
Epidermal growth factor receptor(L858R, T790M)


(Homo sapiens (Human))
BDBM149428
PNG
(US10434101, Compound I-30 | US8975249, I-30)
Show SMILES OCC(=O)N1CCN(CC1)c1ccc(Nc2ncc(c(Nc3cccc(NC(=O)C=C)c3)n2)C(F)(F)F)c(OC(F)(F)F)c1
Show InChI InChI=1S/C27H25F6N7O4/c1-2-22(42)35-16-4-3-5-17(12-16)36-24-19(26(28,29)30)14-34-25(38-24)37-20-7-6-18(13-21(20)44-27(31,32)33)39-8-10-40(11-9-39)23(43)15-41/h2-7,12-14,41H,1,8-11,15H2,(H,35,42)(H2,34,36,37,38)
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n/an/a<1n/an/an/an/an/an/a



Celgene CAR LLC

US Patent


Assay Description
Briefly, 10× stocks of EGFR-WT (PV3872) from Invitrogen and EGFR-T790M/L858R (40350) from BPS Bioscience, San Diego, Calif., 1.13×ATP (AS001A) and ap...


US Patent US10434101 (2019)


BindingDB Entry DOI: 10.7270/Q2NK3HD3
More data for this
Ligand-Target Pair
Epidermal growth factor receptor(L858R, T790M)


(Homo sapiens (Human))
BDBM149431
PNG
(US10434101, Compound I-33 | US8975249, I-33)
Show SMILES CC(=O)N1CCN(CC1)c1ccc(Nc2ncc(c(Nc3cccc(NC(=O)C=C)c3)n2)C(F)(F)F)c(OC(F)(F)F)c1
Show InChI InChI=1S/C27H25F6N7O3/c1-3-23(42)35-17-5-4-6-18(13-17)36-24-20(26(28,29)30)15-34-25(38-24)37-21-8-7-19(14-22(21)43-27(31,32)33)40-11-9-39(10-12-40)16(2)41/h3-8,13-15H,1,9-12H2,2H3,(H,35,42)(H2,34,36,37,38)
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n/an/a<1n/an/an/an/an/an/a



Celgene CAR LLC

US Patent


Assay Description
Briefly, 10× stocks of EGFR-WT (PV3872) from Invitrogen and EGFR-T790M/L858R (40350) from BPS Bioscience, San Diego, Calif., 1.13×ATP (AS001A) and ap...


US Patent US10434101 (2019)


BindingDB Entry DOI: 10.7270/Q2NK3HD3
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM149429
PNG
(US10434101, Compound I-31 | US8975249, I-31)
Show SMILES OCC(=O)N1CCN(CC1)c1ccc(Nc2ncc(c(Nc3cccc(NC(=O)C=C)c3)n2)C(F)(F)F)c(OC(F)F)c1
Show InChI InChI=1S/C27H26F5N7O4/c1-2-22(41)34-16-4-3-5-17(12-16)35-24-19(27(30,31)32)14-33-26(37-24)36-20-7-6-18(13-21(20)43-25(28)29)38-8-10-39(11-9-38)23(42)15-40/h2-7,12-14,25,40H,1,8-11,15H2,(H,34,41)(H2,33,35,36,37)
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n/an/a<1n/an/an/an/an/an/a



Celgene CAR LLC

US Patent


Assay Description
Briefly, 10× stocks of EGFR-WT (PV3872) from Invitrogen and EGFR-T790M/L858R (40350) from BPS Bioscience, San Diego, Calif., 1.13×ATP (AS001A) and ap...


US Patent US10434101 (2019)


BindingDB Entry DOI: 10.7270/Q2NK3HD3
More data for this
Ligand-Target Pair
Epidermal growth factor receptor(L858R, T790M)


(Homo sapiens (Human))
BDBM149403
PNG
(US10434101, Compound I-3 | US8975249, I-3)
Show SMILES COc1cc(ccc1Nc1ncc(Cl)c(Oc2cccc(NC(=O)C=C)c2)n1)N1CCN(CC1)C(=O)CO
Show InChI InChI=1S/C26H27ClN6O5/c1-3-23(35)29-17-5-4-6-19(13-17)38-25-20(27)15-28-26(31-25)30-21-8-7-18(14-22(21)37-2)32-9-11-33(12-10-32)24(36)16-34/h3-8,13-15,34H,1,9-12,16H2,2H3,(H,29,35)(H,28,30,31)
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n/an/a<1n/an/an/an/an/an/a



Celgene CAR LLC

US Patent


Assay Description
Briefly, 10× stocks of EGFR-WT (PV3872) from Invitrogen and EGFR-T790M/L858R (40350) from BPS Bioscience, San Diego, Calif., 1.13×ATP (AS001A) and ap...


US Patent US10434101 (2019)


BindingDB Entry DOI: 10.7270/Q2NK3HD3
More data for this
Ligand-Target Pair
Epidermal growth factor receptor(L858R, T790M)


(Homo sapiens (Human))
BDBM149424
PNG
(US10434101, Compound I-26 | US8975249, I-26)
Show SMILES COc1cc(ccc1Nc1ncc(Cl)c(Oc2cccc(NC(=O)C=C)c2)n1)N1CCN(CC1)S(C)(=O)=O
Show InChI InChI=1S/C25H27ClN6O5S/c1-4-23(33)28-17-6-5-7-19(14-17)37-24-20(26)16-27-25(30-24)29-21-9-8-18(15-22(21)36-2)31-10-12-32(13-11-31)38(3,34)35/h4-9,14-16H,1,10-13H2,2-3H3,(H,28,33)(H,27,29,30)
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n/an/a<1n/an/an/an/an/an/a



Celgene CAR LLC

US Patent


Assay Description
Briefly, 10× stocks of EGFR-WT (PV3872) from Invitrogen and EGFR-T790M/L858R (40350) from BPS Bioscience, San Diego, Calif., 1.13×ATP (AS001A) and ap...


US Patent US10434101 (2019)


BindingDB Entry DOI: 10.7270/Q2NK3HD3
More data for this
Ligand-Target Pair
Epidermal growth factor receptor(L858R, T790M)


(Homo sapiens (Human))
BDBM149420
PNG
(US10434101, Compound I-21 | US8975249, I-21)
Show SMILES CNC(=O)N1CCN(CC1)c1ccc(Nc2ncc(c(Oc3cccc(NC(=O)C=C)c3)n2)C(F)(F)F)c(OC)c1
Show InChI InChI=1S/C27H28F3N7O4/c1-4-23(38)33-17-6-5-7-19(14-17)41-24-20(27(28,29)30)16-32-25(35-24)34-21-9-8-18(15-22(21)40-3)36-10-12-37(13-11-36)26(39)31-2/h4-9,14-16H,1,10-13H2,2-3H3,(H,31,39)(H,33,38)(H,32,34,35)
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n/an/a<1n/an/an/an/an/an/a



Celgene CAR LLC

US Patent


Assay Description
Briefly, 10× stocks of EGFR-WT (PV3872) from Invitrogen and EGFR-T790M/L858R (40350) from BPS Bioscience, San Diego, Calif., 1.13×ATP (AS001A) and ap...


US Patent US10434101 (2019)


BindingDB Entry DOI: 10.7270/Q2NK3HD3
More data for this
Ligand-Target Pair
Epidermal growth factor receptor(L858R, T790M)


(Homo sapiens (Human))
BDBM149413
PNG
(US10434101, Compound I-13 | US8975249, I-13)
Show SMILES FC(F)Oc1cc(ccc1Nc1ncc(c(Oc2cccc(NC(=O)C=C)c2)n1)C(F)(F)F)N1CCOCC1
Show InChI InChI=1S/C25H22F5N5O4/c1-2-21(36)32-15-4-3-5-17(12-15)38-22-18(25(28,29)30)14-31-24(34-22)33-19-7-6-16(13-20(19)39-23(26)27)35-8-10-37-11-9-35/h2-7,12-14,23H,1,8-11H2,(H,32,36)(H,31,33,34)
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n/an/a<1n/an/an/an/an/an/a



Celgene CAR LLC

US Patent


Assay Description
Briefly, 10× stocks of EGFR-WT (PV3872) from Invitrogen and EGFR-T790M/L858R (40350) from BPS Bioscience, San Diego, Calif., 1.13×ATP (AS001A) and ap...


US Patent US10434101 (2019)


BindingDB Entry DOI: 10.7270/Q2NK3HD3
More data for this
Ligand-Target Pair
Epidermal growth factor receptor(L858R, T790M)


(Homo sapiens (Human))
BDBM149436
PNG
(US10434101, Compound I-38 | US8975249, I-38)
Show SMILES COc1cc(ccc1Nc1ncc(c(Nc2cccc(NC(=O)C=C)c2)n1)C(F)(F)F)N1CCCOCC1
Show InChI InChI=1S/C26H27F3N6O3/c1-3-23(36)31-17-6-4-7-18(14-17)32-24-20(26(27,28)29)16-30-25(34-24)33-21-9-8-19(15-22(21)37-2)35-10-5-12-38-13-11-35/h3-4,6-9,14-16H,1,5,10-13H2,2H3,(H,31,36)(H2,30,32,33,34)
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n/an/a<1n/an/an/an/an/an/a



Celgene CAR LLC

US Patent


Assay Description
Briefly, 10× stocks of EGFR-WT (PV3872) from Invitrogen and EGFR-T790M/L858R (40350) from BPS Bioscience, San Diego, Calif., 1.13×ATP (AS001A) and ap...


US Patent US10434101 (2019)


BindingDB Entry DOI: 10.7270/Q2NK3HD3
More data for this
Ligand-Target Pair
Epidermal growth factor receptor(L858R, T790M)


(Homo sapiens (Human))
BDBM149433
PNG
(US10434101, Compound I-35 | US8975249, I-35)
Show SMILES CCC(=O)N1CCN(CC1)c1ccc(Nc2ncc(c(Nc3cccc(NC(=O)C=C)c3)n2)C(F)(F)F)c(OC)c1
Show InChI InChI=1S/C28H30F3N7O3/c1-4-24(39)33-18-7-6-8-19(15-18)34-26-21(28(29,30)31)17-32-27(36-26)35-22-10-9-20(16-23(22)41-3)37-11-13-38(14-12-37)25(40)5-2/h4,6-10,15-17H,1,5,11-14H2,2-3H3,(H,33,39)(H2,32,34,35,36)
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n/an/a<1n/an/an/an/an/an/a



Celgene CAR LLC

US Patent


Assay Description
Briefly, 10× stocks of EGFR-WT (PV3872) from Invitrogen and EGFR-T790M/L858R (40350) from BPS Bioscience, San Diego, Calif., 1.13×ATP (AS001A) and ap...


US Patent US10434101 (2019)


BindingDB Entry DOI: 10.7270/Q2NK3HD3
More data for this
Ligand-Target Pair
Epidermal growth factor receptor(L858R, T790M)


(Homo sapiens (Human))
BDBM149430
PNG
(US10434101, Compound I-32 | US8975249, I-32)
Show SMILES CC(=O)N1CCN(CC1)c1ccc(Nc2ncc(c(Nc3cccc(NC(=O)C=C)c3)n2)C(F)(F)F)c(OC(F)F)c1
Show InChI InChI=1S/C27H26F5N7O3/c1-3-23(41)34-17-5-4-6-18(13-17)35-24-20(27(30,31)32)15-33-26(37-24)36-21-8-7-19(14-22(21)42-25(28)29)39-11-9-38(10-12-39)16(2)40/h3-8,13-15,25H,1,9-12H2,2H3,(H,34,41)(H2,33,35,36,37)
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n/an/a<1n/an/an/an/an/an/a



Celgene CAR LLC

US Patent


Assay Description
Briefly, 10× stocks of EGFR-WT (PV3872) from Invitrogen and EGFR-T790M/L858R (40350) from BPS Bioscience, San Diego, Calif., 1.13×ATP (AS001A) and ap...


US Patent US10434101 (2019)


BindingDB Entry DOI: 10.7270/Q2NK3HD3
More data for this
Ligand-Target Pair
Epidermal growth factor receptor(L858R, T790M)


(Homo sapiens (Human))
BDBM149421
PNG
(US10434101, Compound I-22 | US8975249, I-22)
Show SMILES COc1cc(ccc1Nc1ncc(c(Oc2cccc(NC(=O)C=C)c2)n1)C(F)(F)F)N1CCN(CC1)S(C)(=O)=O
Show InChI InChI=1S/C26H27F3N6O5S/c1-4-23(36)31-17-6-5-7-19(14-17)40-24-20(26(27,28)29)16-30-25(33-24)32-21-9-8-18(15-22(21)39-2)34-10-12-35(13-11-34)41(3,37)38/h4-9,14-16H,1,10-13H2,2-3H3,(H,31,36)(H,30,32,33)
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n/an/a<1n/an/an/an/an/an/a



Celgene CAR LLC

US Patent


Assay Description
Briefly, 10× stocks of EGFR-WT (PV3872) from Invitrogen and EGFR-T790M/L858R (40350) from BPS Bioscience, San Diego, Calif., 1.13×ATP (AS001A) and ap...


US Patent US10434101 (2019)


BindingDB Entry DOI: 10.7270/Q2NK3HD3
More data for this
Ligand-Target Pair
Epidermal growth factor receptor(L858R, T790M)


(Homo sapiens (Human))
BDBM149412
PNG
(US10434101, Compound I-12 | US8975249, I-12)
Show SMILES COc1cc(ccc1Nc1ncc(Cl)c(Nc2cccc(NC(=O)C=C)c2)n1)N1CCN(CC1)C(=O)CO
Show InChI InChI=1S/C26H28ClN7O4/c1-3-23(36)29-17-5-4-6-18(13-17)30-25-20(27)15-28-26(32-25)31-21-8-7-19(14-22(21)38-2)33-9-11-34(12-10-33)24(37)16-35/h3-8,13-15,35H,1,9-12,16H2,2H3,(H,29,36)(H2,28,30,31,32)
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n/an/a<1n/an/an/an/an/an/a



Celgene CAR LLC

US Patent


Assay Description
Briefly, 10× stocks of EGFR-WT (PV3872) from Invitrogen and EGFR-T790M/L858R (40350) from BPS Bioscience, San Diego, Calif., 1.13×ATP (AS001A) and ap...


US Patent US10434101 (2019)


BindingDB Entry DOI: 10.7270/Q2NK3HD3
More data for this
Ligand-Target Pair
Epidermal growth factor receptor(L858R, T790M)


(Homo sapiens (Human))
BDBM149414
PNG
(US10434101, Compound I-14 | US8975249, I-14)
Show SMILES FC(F)Oc1cc(ccc1Nc1ncc(c(Nc2cccc(NC(=O)C=C)c2)n1)C(F)(F)F)N1CCOCC1
Show InChI InChI=1S/C25H23F5N6O3/c1-2-21(37)32-15-4-3-5-16(12-15)33-22-18(25(28,29)30)14-31-24(35-22)34-19-7-6-17(13-20(19)39-23(26)27)36-8-10-38-11-9-36/h2-7,12-14,23H,1,8-11H2,(H,32,37)(H2,31,33,34,35)
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n/an/a<1n/an/an/an/an/an/a



Celgene CAR LLC

US Patent


Assay Description
Briefly, 10× stocks of EGFR-WT (PV3872) from Invitrogen and EGFR-T790M/L858R (40350) from BPS Bioscience, San Diego, Calif., 1.13×ATP (AS001A) and ap...


US Patent US10434101 (2019)


BindingDB Entry DOI: 10.7270/Q2NK3HD3
More data for this
Ligand-Target Pair
Epidermal growth factor receptor(L858R, T790M)


(Homo sapiens (Human))
BDBM149427
PNG
(US10434101, Compound I-29 | US8975249, I-29)
Show SMILES COC(=O)N1CCN(CC1)c1ccc(Nc2ncc(c(Nc3cccc(NC(=O)C=C)c3)n2)C(F)(F)F)c(OC)c1
Show InChI InChI=1S/C27H28F3N7O4/c1-4-23(38)32-17-6-5-7-18(14-17)33-24-20(27(28,29)30)16-31-25(35-24)34-21-9-8-19(15-22(21)40-2)36-10-12-37(13-11-36)26(39)41-3/h4-9,14-16H,1,10-13H2,2-3H3,(H,32,38)(H2,31,33,34,35)
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n/an/a<1n/an/an/an/an/an/a



Celgene CAR LLC

US Patent


Assay Description
Briefly, 10× stocks of EGFR-WT (PV3872) from Invitrogen and EGFR-T790M/L858R (40350) from BPS Bioscience, San Diego, Calif., 1.13×ATP (AS001A) and ap...


US Patent US10434101 (2019)


BindingDB Entry DOI: 10.7270/Q2NK3HD3
More data for this
Ligand-Target Pair
Epidermal growth factor receptor(L858R, T790M)


(Homo sapiens (Human))
BDBM149402
PNG
(US10434101, Compound I-2 | US8975249, I-2)
Show SMILES COc1cc(ccc1Nc1ncc(c(Nc2cccc(NC(=O)C=C)c2)n1)C(F)(F)F)N1CCOCC1
Show InChI InChI=1S/C25H25F3N6O3/c1-3-22(35)30-16-5-4-6-17(13-16)31-23-19(25(26,27)28)15-29-24(33-23)32-20-8-7-18(14-21(20)36-2)34-9-11-37-12-10-34/h3-8,13-15H,1,9-12H2,2H3,(H,30,35)(H2,29,31,32,33)
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n/an/a<1n/an/an/an/an/an/a



Celgene CAR LLC

US Patent


Assay Description
Briefly, 10× stocks of EGFR-WT (PV3872) from Invitrogen and EGFR-T790M/L858R (40350) from BPS Bioscience, San Diego, Calif., 1.13×ATP (AS001A) and ap...


US Patent US10434101 (2019)


BindingDB Entry DOI: 10.7270/Q2NK3HD3
More data for this
Ligand-Target Pair
Epidermal growth factor receptor(L858R, T790M)


(Homo sapiens (Human))
BDBM149447
PNG
(US10434101, Compound I-49 | US8975249, I-49)
Show SMILES COc1cc(ccc1Nc1ncc(c(Nc2cccc(NC(=O)C=C)c2)n1)C(F)(F)F)N1CCS(=O)(=O)CC1
Show InChI InChI=1S/C25H25F3N6O4S/c1-3-22(35)30-16-5-4-6-17(13-16)31-23-19(25(26,27)28)15-29-24(33-23)32-20-8-7-18(14-21(20)38-2)34-9-11-39(36,37)12-10-34/h3-8,13-15H,1,9-12H2,2H3,(H,30,35)(H2,29,31,32,33)
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Celgene CAR LLC

US Patent


Assay Description
Briefly, 10× stocks of EGFR-WT (PV3872) from Invitrogen and EGFR-T790M/L858R (40350) from BPS Bioscience, San Diego, Calif., 1.13×ATP (AS001A) and ap...


US Patent US10434101 (2019)


BindingDB Entry DOI: 10.7270/Q2NK3HD3
More data for this
Ligand-Target Pair
Epidermal growth factor receptor(L858R, T790M)


(Homo sapiens (Human))
BDBM149444
PNG
(US10434101, Compound I-46 | US8975249, I-46)
Show SMILES COc1cc(ccc1Nc1ncc(Cl)c(Oc2cccc(NC(=O)C=C)c2)n1)N1CCN(CC1)C(=O)OC(C)(C)C
Show InChI InChI=1S/C29H33ClN6O5/c1-6-25(37)32-19-8-7-9-21(16-19)40-26-22(30)18-31-27(34-26)33-23-11-10-20(17-24(23)39-5)35-12-14-36(15-13-35)28(38)41-29(2,3)4/h6-11,16-18H,1,12-15H2,2-5H3,(H,32,37)(H,31,33,34)
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Celgene CAR LLC

US Patent


Assay Description
Briefly, 10× stocks of EGFR-WT (PV3872) from Invitrogen and EGFR-T790M/L858R (40350) from BPS Bioscience, San Diego, Calif., 1.13×ATP (AS001A) and ap...


US Patent US10434101 (2019)


BindingDB Entry DOI: 10.7270/Q2NK3HD3
More data for this
Ligand-Target Pair
Epidermal growth factor receptor(L858R, T790M)


(Homo sapiens (Human))
BDBM149409
PNG
(US10434101, Compound I-9 | US8975249, I-9)
Show SMILES COc1cc(ccc1Nc1ncc(Cl)c(Oc2cccc(NC(=O)C=C)c2)n1)N1CCN(CC1)C(C)=O
Show InChI InChI=1S/C26H27ClN6O4/c1-4-24(35)29-18-6-5-7-20(14-18)37-25-21(27)16-28-26(31-25)30-22-9-8-19(15-23(22)36-3)33-12-10-32(11-13-33)17(2)34/h4-9,14-16H,1,10-13H2,2-3H3,(H,29,35)(H,28,30,31)
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Celgene CAR LLC

US Patent


Assay Description
Briefly, 10× stocks of EGFR-WT (PV3872) from Invitrogen and EGFR-T790M/L858R (40350) from BPS Bioscience, San Diego, Calif., 1.13×ATP (AS001A) and ap...


US Patent US10434101 (2019)


BindingDB Entry DOI: 10.7270/Q2NK3HD3
More data for this
Ligand-Target Pair
Epidermal growth factor receptor(L858R, T790M)


(Homo sapiens (Human))
BDBM149406
PNG
(US10434101, Compound I-6 | US8975249, I-6)
Show SMILES COc1cc(ccc1Nc1ncc(c(Nc2cccc(NC(=O)C=C)c2)n1)C(F)(F)F)N1CCN(CC1)C(=O)CO
Show InChI InChI=1S/C27H28F3N7O4/c1-3-23(39)32-17-5-4-6-18(13-17)33-25-20(27(28,29)30)15-31-26(35-25)34-21-8-7-19(14-22(21)41-2)36-9-11-37(12-10-36)24(40)16-38/h3-8,13-15,38H,1,9-12,16H2,2H3,(H,32,39)(H2,31,33,34,35)
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Celgene CAR LLC

US Patent


Assay Description
Briefly, 10× stocks of EGFR-WT (PV3872) from Invitrogen and EGFR-T790M/L858R (40350) from BPS Bioscience, San Diego, Calif., 1.13×ATP (AS001A) and ap...


US Patent US10434101 (2019)


BindingDB Entry DOI: 10.7270/Q2NK3HD3
More data for this
Ligand-Target Pair
Epidermal growth factor receptor(L858R, T790M)


(Homo sapiens (Human))
BDBM149407
PNG
(US10434101, Compound I-7 | US8975249, I-7)
Show SMILES COc1cc(ccc1Nc1ncc(c(Nc2cccc(NC(=O)C=C)c2)n1)C(F)(F)F)N1CCCN(CC1)C(C)=O
Show InChI InChI=1S/C28H30F3N7O3/c1-4-25(40)33-19-7-5-8-20(15-19)34-26-22(28(29,30)31)17-32-27(36-26)35-23-10-9-21(16-24(23)41-3)38-12-6-11-37(13-14-38)18(2)39/h4-5,7-10,15-17H,1,6,11-14H2,2-3H3,(H,33,40)(H2,32,34,35,36)
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Celgene CAR LLC

US Patent


Assay Description
Briefly, 10× stocks of EGFR-WT (PV3872) from Invitrogen and EGFR-T790M/L858R (40350) from BPS Bioscience, San Diego, Calif., 1.13×ATP (AS001A) and ap...


US Patent US10434101 (2019)


BindingDB Entry DOI: 10.7270/Q2NK3HD3
More data for this
Ligand-Target Pair
Epidermal growth factor receptor(L858R, T790M)


(Homo sapiens (Human))
BDBM149416
PNG
(US10434101, Compound I-17 | US8975249, I-17)
Show SMILES COc1cc(ccc1Nc1ncc(c(Nc2cccc(NC(=O)C=C)c2)n1)C(F)(F)F)N1CCN(CC1)S(C)(=O)=O
Show InChI InChI=1S/C26H28F3N7O4S/c1-4-23(37)31-17-6-5-7-18(14-17)32-24-20(26(27,28)29)16-30-25(34-24)33-21-9-8-19(15-22(21)40-2)35-10-12-36(13-11-35)41(3,38)39/h4-9,14-16H,1,10-13H2,2-3H3,(H,31,37)(H2,30,32,33,34)
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Celgene CAR LLC

US Patent


Assay Description
Briefly, 10× stocks of EGFR-WT (PV3872) from Invitrogen and EGFR-T790M/L858R (40350) from BPS Bioscience, San Diego, Calif., 1.13×ATP (AS001A) and ap...


US Patent US10434101 (2019)


BindingDB Entry DOI: 10.7270/Q2NK3HD3
More data for this
Ligand-Target Pair
Epidermal growth factor receptor(L858R, T790M)


(Homo sapiens (Human))
BDBM149411
PNG
(US10434101, Compound I-11 | US8975249, I-11)
Show SMILES COc1cc(ccc1Nc1ncc(c(Oc2cccc(NC(=O)C=C)c2)n1)C(F)(F)F)N1CCN(CC1)C(=O)CO
Show InChI InChI=1S/C27H27F3N6O5/c1-3-23(38)32-17-5-4-6-19(13-17)41-25-20(27(28,29)30)15-31-26(34-25)33-21-8-7-18(14-22(21)40-2)35-9-11-36(12-10-35)24(39)16-37/h3-8,13-15,37H,1,9-12,16H2,2H3,(H,32,38)(H,31,33,34)
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Celgene CAR LLC

US Patent


Assay Description
Briefly, 10× stocks of EGFR-WT (PV3872) from Invitrogen and EGFR-T790M/L858R (40350) from BPS Bioscience, San Diego, Calif., 1.13×ATP (AS001A) and ap...


US Patent US10434101 (2019)


BindingDB Entry DOI: 10.7270/Q2NK3HD3
More data for this
Ligand-Target Pair
Epidermal growth factor receptor(L858R, T790M)


(Homo sapiens (Human))
BDBM149426
PNG
(US10434101, Compound I-28 | US8975249, I-28)
Show SMILES CNC(=O)N1CCN(CC1)c1ccc(Nc2ncc(c(Nc3cccc(NC(=O)C=C)c3)n2)C(F)(F)F)c(OC)c1
Show InChI InChI=1S/C27H29F3N8O3/c1-4-23(39)33-17-6-5-7-18(14-17)34-24-20(27(28,29)30)16-32-25(36-24)35-21-9-8-19(15-22(21)41-3)37-10-12-38(13-11-37)26(40)31-2/h4-9,14-16H,1,10-13H2,2-3H3,(H,31,40)(H,33,39)(H2,32,34,35,36)
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Celgene CAR LLC

US Patent


Assay Description
Briefly, 10× stocks of EGFR-WT (PV3872) from Invitrogen and EGFR-T790M/L858R (40350) from BPS Bioscience, San Diego, Calif., 1.13×ATP (AS001A) and ap...


US Patent US10434101 (2019)


BindingDB Entry DOI: 10.7270/Q2NK3HD3
More data for this
Ligand-Target Pair
Epidermal growth factor receptor(L858R, T790M)


(Homo sapiens (Human))
BDBM149429
PNG
(US10434101, Compound I-31 | US8975249, I-31)
Show SMILES OCC(=O)N1CCN(CC1)c1ccc(Nc2ncc(c(Nc3cccc(NC(=O)C=C)c3)n2)C(F)(F)F)c(OC(F)F)c1
Show InChI InChI=1S/C27H26F5N7O4/c1-2-22(41)34-16-4-3-5-17(12-16)35-24-19(27(30,31)32)14-33-26(37-24)36-20-7-6-18(13-21(20)43-25(28)29)38-8-10-39(11-9-38)23(42)15-40/h2-7,12-14,25,40H,1,8-11,15H2,(H,34,41)(H2,33,35,36,37)
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Celgene CAR LLC

US Patent


Assay Description
Briefly, 10× stocks of EGFR-WT (PV3872) from Invitrogen and EGFR-T790M/L858R (40350) from BPS Bioscience, San Diego, Calif., 1.13×ATP (AS001A) and ap...


US Patent US10434101 (2019)


BindingDB Entry DOI: 10.7270/Q2NK3HD3
More data for this
Ligand-Target Pair
Epidermal growth factor receptor(L858R, T790M)


(Homo sapiens (Human))
BDBM149404
PNG
(AVL-301 | CHEMBL3545308 | CNX-419 | CO-1686 | Roci...)
Show SMILES COc1cc(ccc1Nc1ncc(c(Nc2cccc(NC(=O)C=C)c2)n1)C(F)(F)F)N1CCN(CC1)C(C)=O
Show InChI InChI=1S/C27H28F3N7O3/c1-4-24(39)32-18-6-5-7-19(14-18)33-25-21(27(28,29)30)16-31-26(35-25)34-22-9-8-20(15-23(22)40-3)37-12-10-36(11-13-37)17(2)38/h4-9,14-16H,1,10-13H2,2-3H3,(H,32,39)(H2,31,33,34,35)
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Celgene CAR LLC

US Patent


Assay Description
Briefly, 10× stocks of EGFR-WT (PV3872) from Invitrogen and EGFR-T790M/L858R (40350) from BPS Bioscience, San Diego, Calif., 1.13×ATP (AS001A) and ap...


US Patent US10434101 (2019)


BindingDB Entry DOI: 10.7270/Q2NK3HD3
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Epidermal growth factor receptor(L858R, T790M)


(Homo sapiens (Human))
BDBM149446
PNG
(US10434101, Compound I-48 | US8975249, I-48)
Show SMILES COC(=O)[C@@H]1CN(CCN1C(C)=O)c1ccc(Nc2ncc(c(Nc3cccc(NC(=O)C=C)c3)n2)C(F)(F)F)c(OC)c1
Show InChI InChI=1S/C29H30F3N7O5/c1-5-25(41)34-18-7-6-8-19(13-18)35-26-21(29(30,31)32)15-33-28(37-26)36-22-10-9-20(14-24(22)43-3)38-11-12-39(17(2)40)23(16-38)27(42)44-4/h5-10,13-15,23H,1,11-12,16H2,2-4H3,(H,34,41)(H2,33,35,36,37)/t23-/m0/s1
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Celgene CAR LLC

US Patent


Assay Description
Briefly, 10× stocks of EGFR-WT (PV3872) from Invitrogen and EGFR-T790M/L858R (40350) from BPS Bioscience, San Diego, Calif., 1.13×ATP (AS001A) and ap...


US Patent US10434101 (2019)


BindingDB Entry DOI: 10.7270/Q2NK3HD3
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM149430
PNG
(US10434101, Compound I-32 | US8975249, I-32)
Show SMILES CC(=O)N1CCN(CC1)c1ccc(Nc2ncc(c(Nc3cccc(NC(=O)C=C)c3)n2)C(F)(F)F)c(OC(F)F)c1
Show InChI InChI=1S/C27H26F5N7O3/c1-3-23(41)34-17-5-4-6-18(13-17)35-24-20(27(30,31)32)15-33-26(37-24)36-21-8-7-19(14-22(21)42-25(28)29)39-11-9-38(10-12-39)16(2)40/h3-8,13-15,25H,1,9-12H2,2H3,(H,34,41)(H2,33,35,36,37)
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Celgene CAR LLC

US Patent


Assay Description
Briefly, 10× stocks of EGFR-WT (PV3872) from Invitrogen and EGFR-T790M/L858R (40350) from BPS Bioscience, San Diego, Calif., 1.13×ATP (AS001A) and ap...


US Patent US10434101 (2019)


BindingDB Entry DOI: 10.7270/Q2NK3HD3
More data for this
Ligand-Target Pair
Epidermal growth factor receptor(L858R, T790M)


(Homo sapiens (Human))
BDBM149443
PNG
(US10434101, Compound I-45 | US8975249, I-45)
Show SMILES COc1cc(ccc1Nc1ncc(c(Nc2cccc(NC(=O)C=C)c2)n1)C(F)(F)F)N1CCN(CC1)C(=O)CC(C)(C)C
Show InChI InChI=1S/C31H36F3N7O3/c1-6-26(42)36-20-8-7-9-21(16-20)37-28-23(31(32,33)34)19-35-29(39-28)38-24-11-10-22(17-25(24)44-5)40-12-14-41(15-13-40)27(43)18-30(2,3)4/h6-11,16-17,19H,1,12-15,18H2,2-5H3,(H,36,42)(H2,35,37,38,39)
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Celgene CAR LLC

US Patent


Assay Description
Briefly, 10× stocks of EGFR-WT (PV3872) from Invitrogen and EGFR-T790M/L858R (40350) from BPS Bioscience, San Diego, Calif., 1.13×ATP (AS001A) and ap...


US Patent US10434101 (2019)


BindingDB Entry DOI: 10.7270/Q2NK3HD3
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM149410
PNG
(US10434101, Compound I-10 | US8975249, I-10)
Show SMILES COc1cc(ccc1Nc1ncc(c(Oc2cccc(NC(=O)C=C)c2)n1)C(F)(F)F)N1CCN(CC1)C(C)=O
Show InChI InChI=1S/C27H27F3N6O4/c1-4-24(38)32-18-6-5-7-20(14-18)40-25-21(27(28,29)30)16-31-26(34-25)33-22-9-8-19(15-23(22)39-3)36-12-10-35(11-13-36)17(2)37/h4-9,14-16H,1,10-13H2,2-3H3,(H,32,38)(H,31,33,34)
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Celgene CAR LLC

US Patent


Assay Description
Briefly, 10× stocks of EGFR-WT (PV3872) from Invitrogen and EGFR-T790M/L858R (40350) from BPS Bioscience, San Diego, Calif., 1.13×ATP (AS001A) and ap...


US Patent US10434101 (2019)


BindingDB Entry DOI: 10.7270/Q2NK3HD3
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM149406
PNG
(US10434101, Compound I-6 | US8975249, I-6)
Show SMILES COc1cc(ccc1Nc1ncc(c(Nc2cccc(NC(=O)C=C)c2)n1)C(F)(F)F)N1CCN(CC1)C(=O)CO
Show InChI InChI=1S/C27H28F3N7O4/c1-3-23(39)32-17-5-4-6-18(13-17)33-25-20(27(28,29)30)15-31-26(35-25)34-21-8-7-19(14-22(21)41-2)36-9-11-37(12-10-36)24(40)16-38/h3-8,13-15,38H,1,9-12,16H2,2H3,(H,32,39)(H2,31,33,34,35)
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Celgene CAR LLC

US Patent


Assay Description
Briefly, 10× stocks of EGFR-WT (PV3872) from Invitrogen and EGFR-T790M/L858R (40350) from BPS Bioscience, San Diego, Calif., 1.13×ATP (AS001A) and ap...


US Patent US10434101 (2019)


BindingDB Entry DOI: 10.7270/Q2NK3HD3
More data for this
Ligand-Target Pair
Epidermal growth factor receptor(L858R, T790M)


(Homo sapiens (Human))
BDBM149401
PNG
(US10434101, Compound I-1 | US8975249, I-1)
Show SMILES COc1cc(ccc1Nc1ncc(c(Oc2cccc(NC(=O)C=C)c2)n1)C(F)(F)F)N1CCOCC1
Show InChI InChI=1S/C25H24F3N5O4/c1-3-22(34)30-16-5-4-6-18(13-16)37-23-19(25(26,27)28)15-29-24(32-23)31-20-8-7-17(14-21(20)35-2)33-9-11-36-12-10-33/h3-8,13-15H,1,9-12H2,2H3,(H,30,34)(H,29,31,32)
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Celgene CAR LLC

US Patent


Assay Description
Briefly, 10× stocks of EGFR-WT (PV3872) from Invitrogen and EGFR-T790M/L858R (40350) from BPS Bioscience, San Diego, Calif., 1.13×ATP (AS001A) and ap...


US Patent US10434101 (2019)


BindingDB Entry DOI: 10.7270/Q2NK3HD3
More data for this
Ligand-Target Pair
Epidermal growth factor receptor(L858R, T790M)


(Homo sapiens (Human))
BDBM149437
PNG
(US10434101, Compound I-44 | US8975249, I-39 | US89...)
Show SMILES COc1cc(ccc1Nc1ncc(c(Nc2cccc(NC(=O)C=C)c2)n1)C(F)(F)F)N1CCCN(CC1)C(=O)OC(C)(C)C
Show InChI InChI=1S/C31H36F3N7O4/c1-6-26(42)36-20-9-7-10-21(17-20)37-27-23(31(32,33)34)19-35-28(39-27)38-24-12-11-22(18-25(24)44-5)40-13-8-14-41(16-15-40)29(43)45-30(2,3)4/h6-7,9-12,17-19H,1,8,13-16H2,2-5H3,(H,36,42)(H2,35,37,38,39)
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Celgene CAR LLC

US Patent


Assay Description
Briefly, 10× stocks of EGFR-WT (PV3872) from Invitrogen and EGFR-T790M/L858R (40350) from BPS Bioscience, San Diego, Calif., 1.13×ATP (AS001A) and ap...


US Patent US10434101 (2019)


BindingDB Entry DOI: 10.7270/Q2NK3HD3
More data for this
Ligand-Target Pair
Epidermal growth factor receptor(L858R, T790M)


(Homo sapiens (Human))
BDBM149418
PNG
(US10434101, Compound I-19 | US8975249, I-19)
Show SMILES COc1cc(ccc1Nc1ncc(c(Nc2cccc(NC(=O)C=C)c2)n1)C(F)(F)F)N1CCCN(CC1)C(=O)C(F)(F)F
Show InChI InChI=1S/C28H27F6N7O3/c1-3-23(42)36-17-6-4-7-18(14-17)37-24-20(27(29,30)31)16-35-26(39-24)38-21-9-8-19(15-22(21)44-2)40-10-5-11-41(13-12-40)25(43)28(32,33)34/h3-4,6-9,14-16H,1,5,10-13H2,2H3,(H,36,42)(H2,35,37,38,39)
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Celgene CAR LLC

US Patent


Assay Description
Briefly, 10× stocks of EGFR-WT (PV3872) from Invitrogen and EGFR-T790M/L858R (40350) from BPS Bioscience, San Diego, Calif., 1.13×ATP (AS001A) and ap...


US Patent US10434101 (2019)


BindingDB Entry DOI: 10.7270/Q2NK3HD3
More data for this
Ligand-Target Pair
Epidermal growth factor receptor(L858R, T790M)


(Homo sapiens (Human))
BDBM149410
PNG
(US10434101, Compound I-10 | US8975249, I-10)
Show SMILES COc1cc(ccc1Nc1ncc(c(Oc2cccc(NC(=O)C=C)c2)n1)C(F)(F)F)N1CCN(CC1)C(C)=O
Show InChI InChI=1S/C27H27F3N6O4/c1-4-24(38)32-18-6-5-7-20(14-18)40-25-21(27(28,29)30)16-31-26(34-25)33-22-9-8-19(15-23(22)39-3)36-12-10-35(11-13-36)17(2)37/h4-9,14-16H,1,10-13H2,2-3H3,(H,32,38)(H,31,33,34)
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Celgene CAR LLC

US Patent


Assay Description
Briefly, 10× stocks of EGFR-WT (PV3872) from Invitrogen and EGFR-T790M/L858R (40350) from BPS Bioscience, San Diego, Calif., 1.13×ATP (AS001A) and ap...


US Patent US10434101 (2019)


BindingDB Entry DOI: 10.7270/Q2NK3HD3
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM149404
PNG
(AVL-301 | CHEMBL3545308 | CNX-419 | CO-1686 | Roci...)
Show SMILES COc1cc(ccc1Nc1ncc(c(Nc2cccc(NC(=O)C=C)c2)n1)C(F)(F)F)N1CCN(CC1)C(C)=O
Show InChI InChI=1S/C27H28F3N7O3/c1-4-24(39)32-18-6-5-7-19(14-18)33-25-21(27(28,29)30)16-31-26(35-25)34-22-9-8-20(15-23(22)40-3)37-12-10-36(11-13-37)17(2)38/h4-9,14-16H,1,10-13H2,2-3H3,(H,32,39)(H2,31,33,34,35)
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n/an/a 5.5n/an/an/an/an/an/a



Celgene CAR LLC

US Patent


Assay Description
Briefly, 10× stocks of EGFR-WT (PV3872) from Invitrogen and EGFR-T790M/L858R (40350) from BPS Bioscience, San Diego, Calif., 1.13×ATP (AS001A) and ap...


US Patent US10434101 (2019)


BindingDB Entry DOI: 10.7270/Q2NK3HD3
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM149403
PNG
(US10434101, Compound I-3 | US8975249, I-3)
Show SMILES COc1cc(ccc1Nc1ncc(Cl)c(Oc2cccc(NC(=O)C=C)c2)n1)N1CCN(CC1)C(=O)CO
Show InChI InChI=1S/C26H27ClN6O5/c1-3-23(35)29-17-5-4-6-19(13-17)38-25-20(27)15-28-26(31-25)30-21-8-7-18(14-22(21)37-2)32-9-11-33(12-10-32)24(36)16-34/h3-8,13-15,34H,1,9-12,16H2,2H3,(H,29,35)(H,28,30,31)
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Celgene CAR LLC

US Patent


Assay Description
Briefly, 10× stocks of EGFR-WT (PV3872) from Invitrogen and EGFR-T790M/L858R (40350) from BPS Bioscience, San Diego, Calif., 1.13×ATP (AS001A) and ap...


US Patent US10434101 (2019)


BindingDB Entry DOI: 10.7270/Q2NK3HD3
More data for this
Ligand-Target Pair
Epidermal growth factor receptor(L858R, T790M)


(Homo sapiens (Human))
BDBM149441
PNG
(US10434101, Compound I-43 | US8975249, I-43)
Show SMILES COc1cc(ccc1Nc1ncc(Cl)c(Oc2cccc(NC(=O)C=C)c2)n1)N1CCCN(CC1)C(=O)OC(C)(C)C
Show InChI InChI=1S/C30H35ClN6O5/c1-6-26(38)33-20-9-7-10-22(17-20)41-27-23(31)19-32-28(35-27)34-24-12-11-21(18-25(24)40-5)36-13-8-14-37(16-15-36)29(39)42-30(2,3)4/h6-7,9-12,17-19H,1,8,13-16H2,2-5H3,(H,33,38)(H,32,34,35)
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Celgene CAR LLC

US Patent


Assay Description
Briefly, 10× stocks of EGFR-WT (PV3872) from Invitrogen and EGFR-T790M/L858R (40350) from BPS Bioscience, San Diego, Calif., 1.13×ATP (AS001A) and ap...


US Patent US10434101 (2019)


BindingDB Entry DOI: 10.7270/Q2NK3HD3
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM149409
PNG
(US10434101, Compound I-9 | US8975249, I-9)
Show SMILES COc1cc(ccc1Nc1ncc(Cl)c(Oc2cccc(NC(=O)C=C)c2)n1)N1CCN(CC1)C(C)=O
Show InChI InChI=1S/C26H27ClN6O4/c1-4-24(35)29-18-6-5-7-20(14-18)37-25-21(27)16-28-26(31-25)30-22-9-8-19(15-23(22)36-3)33-12-10-32(11-13-33)17(2)34/h4-9,14-16H,1,10-13H2,2-3H3,(H,29,35)(H,28,30,31)
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Celgene CAR LLC

US Patent


Assay Description
Briefly, 10× stocks of EGFR-WT (PV3872) from Invitrogen and EGFR-T790M/L858R (40350) from BPS Bioscience, San Diego, Calif., 1.13×ATP (AS001A) and ap...


US Patent US10434101 (2019)


BindingDB Entry DOI: 10.7270/Q2NK3HD3
More data for this
Ligand-Target Pair
Epidermal growth factor receptor(L858R, T790M)


(Homo sapiens (Human))
BDBM149405
PNG
(US10434101, Compound I-5 | US8975249, I-15 | US897...)
Show SMILES COc1cc(ccc1Nc1ncc(Cl)c(Oc2cccc(NC(=O)C=C)c2)n1)N1CCOCC1
Show InChI InChI=1S/C24H24ClN5O4/c1-3-22(31)27-16-5-4-6-18(13-16)34-23-19(25)15-26-24(29-23)28-20-8-7-17(14-21(20)32-2)30-9-11-33-12-10-30/h3-8,13-15H,1,9-12H2,2H3,(H,27,31)(H,26,28,29)
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Celgene CAR LLC

US Patent


Assay Description
Briefly, 10× stocks of EGFR-WT (PV3872) from Invitrogen and EGFR-T790M/L858R (40350) from BPS Bioscience, San Diego, Calif., 1.13×ATP (AS001A) and ap...


US Patent US10434101 (2019)


BindingDB Entry DOI: 10.7270/Q2NK3HD3
More data for this
Ligand-Target Pair
Epidermal growth factor receptor(L858R, T790M)


(Homo sapiens (Human))
BDBM149435
PNG
(US10434101, Compound I-37 | US8975249, I-37)
Show SMILES COc1cc(ccc1Nc1ncc(Cl)c(Oc2cccc(NC(=O)C=C)c2)n1)N1CCCOCC1
Show InChI InChI=1S/C25H26ClN5O4/c1-3-23(32)28-17-6-4-7-19(14-17)35-24-20(26)16-27-25(30-24)29-21-9-8-18(15-22(21)33-2)31-10-5-12-34-13-11-31/h3-4,6-9,14-16H,1,5,10-13H2,2H3,(H,28,32)(H,27,29,30)
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Celgene CAR LLC

US Patent


Assay Description
Briefly, 10× stocks of EGFR-WT (PV3872) from Invitrogen and EGFR-T790M/L858R (40350) from BPS Bioscience, San Diego, Calif., 1.13×ATP (AS001A) and ap...


US Patent US10434101 (2019)


BindingDB Entry DOI: 10.7270/Q2NK3HD3
More data for this
Ligand-Target Pair
Epidermal growth factor receptor(L858R, T790M)


(Homo sapiens (Human))
BDBM149425
PNG
(US10434101, Compound I-27 | US8975249, I-27)
Show SMILES COc1cc(ccc1Nc1ncc(c(Oc2cccc(NC(=O)C=C)c2)n1)C(F)(F)F)N1CCN(CC1)S(N)(=O)=O
Show InChI InChI=1S/C25H26F3N7O5S/c1-3-22(36)31-16-5-4-6-18(13-16)40-23-19(25(26,27)28)15-30-24(33-23)32-20-8-7-17(14-21(20)39-2)34-9-11-35(12-10-34)41(29,37)38/h3-8,13-15H,1,9-12H2,2H3,(H,31,36)(H2,29,37,38)(H,30,32,33)
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Celgene CAR LLC

US Patent


Assay Description
Briefly, 10× stocks of EGFR-WT (PV3872) from Invitrogen and EGFR-T790M/L858R (40350) from BPS Bioscience, San Diego, Calif., 1.13×ATP (AS001A) and ap...


US Patent US10434101 (2019)


BindingDB Entry DOI: 10.7270/Q2NK3HD3
More data for this
Ligand-Target Pair
Epidermal growth factor receptor(L858R, T790M)


(Homo sapiens (Human))
BDBM149419
PNG
(US10434101, Compound I-20 | US8975249, I-20)
Show SMILES COC(=O)N1CCN(CC1)c1ccc(Nc2ncc(c(Oc3cccc(NC(=O)C=C)c3)n2)C(F)(F)F)c(OC)c1
Show InChI InChI=1S/C27H27F3N6O5/c1-4-23(37)32-17-6-5-7-19(14-17)41-24-20(27(28,29)30)16-31-25(34-24)33-21-9-8-18(15-22(21)39-2)35-10-12-36(13-11-35)26(38)40-3/h4-9,14-16H,1,10-13H2,2-3H3,(H,32,37)(H,31,33,34)
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Celgene CAR LLC

US Patent


Assay Description
Briefly, 10× stocks of EGFR-WT (PV3872) from Invitrogen and EGFR-T790M/L858R (40350) from BPS Bioscience, San Diego, Calif., 1.13×ATP (AS001A) and ap...


US Patent US10434101 (2019)


BindingDB Entry DOI: 10.7270/Q2NK3HD3
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM149447
PNG
(US10434101, Compound I-49 | US8975249, I-49)
Show SMILES COc1cc(ccc1Nc1ncc(c(Nc2cccc(NC(=O)C=C)c2)n1)C(F)(F)F)N1CCS(=O)(=O)CC1
Show InChI InChI=1S/C25H25F3N6O4S/c1-3-22(35)30-16-5-4-6-17(13-16)31-23-19(25(26,27)28)15-29-24(33-23)32-20-8-7-18(14-21(20)38-2)34-9-11-39(36,37)12-10-34/h3-8,13-15H,1,9-12H2,2H3,(H,30,35)(H2,29,31,32,33)
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Celgene CAR LLC

US Patent


Assay Description
Briefly, 10× stocks of EGFR-WT (PV3872) from Invitrogen and EGFR-T790M/L858R (40350) from BPS Bioscience, San Diego, Calif., 1.13×ATP (AS001A) and ap...


US Patent US10434101 (2019)


BindingDB Entry DOI: 10.7270/Q2NK3HD3
More data for this
Ligand-Target Pair
Epidermal growth factor receptor(L858R, T790M)


(Homo sapiens (Human))
BDBM149439
PNG
(US10434101, Compound I-41 | US8975249, I-41)
Show SMILES COc1cc(ccc1Nc1ncc(Cl)c(Nc2cccc(NC(=O)C=C)c2)n1)N1CCN(CC1)S(C)(=O)=O
Show InChI InChI=1S/C25H28ClN7O4S/c1-4-23(34)28-17-6-5-7-18(14-17)29-24-20(26)16-27-25(31-24)30-21-9-8-19(15-22(21)37-2)32-10-12-33(13-11-32)38(3,35)36/h4-9,14-16H,1,10-13H2,2-3H3,(H,28,34)(H2,27,29,30,31)
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Celgene CAR LLC

US Patent


Assay Description
Briefly, 10× stocks of EGFR-WT (PV3872) from Invitrogen and EGFR-T790M/L858R (40350) from BPS Bioscience, San Diego, Calif., 1.13×ATP (AS001A) and ap...


US Patent US10434101 (2019)


BindingDB Entry DOI: 10.7270/Q2NK3HD3
More data for this
Ligand-Target Pair
Epidermal growth factor receptor(L858R, T790M)


(Homo sapiens (Human))
BDBM149438
PNG
(US10434101, Compound I-40 | US8975249, I-40)
Show SMILES COc1cc(ccc1Nc1ncc(Br)c(Nc2cccc(NC(=O)C=C)c2)n1)N1CCN(CC1)C(C)=O
Show InChI InChI=1S/C26H28BrN7O3/c1-4-24(36)29-18-6-5-7-19(14-18)30-25-21(27)16-28-26(32-25)31-22-9-8-20(15-23(22)37-3)34-12-10-33(11-13-34)17(2)35/h4-9,14-16H,1,10-13H2,2-3H3,(H,29,36)(H2,28,30,31,32)
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Celgene CAR LLC

US Patent


Assay Description
Briefly, 10× stocks of EGFR-WT (PV3872) from Invitrogen and EGFR-T790M/L858R (40350) from BPS Bioscience, San Diego, Calif., 1.13×ATP (AS001A) and ap...


US Patent US10434101 (2019)


BindingDB Entry DOI: 10.7270/Q2NK3HD3
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM149433
PNG
(US10434101, Compound I-35 | US8975249, I-35)
Show SMILES CCC(=O)N1CCN(CC1)c1ccc(Nc2ncc(c(Nc3cccc(NC(=O)C=C)c3)n2)C(F)(F)F)c(OC)c1
Show InChI InChI=1S/C28H30F3N7O3/c1-4-24(39)33-18-7-6-8-19(15-18)34-26-21(28(29,30)31)17-32-27(36-26)35-22-10-9-20(16-23(22)41-3)37-11-13-38(14-12-37)25(40)5-2/h4,6-10,15-17H,1,5,11-14H2,2-3H3,(H,33,39)(H2,32,34,35,36)
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Celgene CAR LLC

US Patent


Assay Description
Briefly, 10× stocks of EGFR-WT (PV3872) from Invitrogen and EGFR-T790M/L858R (40350) from BPS Bioscience, San Diego, Calif., 1.13×ATP (AS001A) and ap...


US Patent US10434101 (2019)


BindingDB Entry DOI: 10.7270/Q2NK3HD3
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM149431
PNG
(US10434101, Compound I-33 | US8975249, I-33)
Show SMILES CC(=O)N1CCN(CC1)c1ccc(Nc2ncc(c(Nc3cccc(NC(=O)C=C)c3)n2)C(F)(F)F)c(OC(F)(F)F)c1
Show InChI InChI=1S/C27H25F6N7O3/c1-3-23(42)35-17-5-4-6-18(13-17)36-24-20(26(28,29)30)15-34-25(38-24)37-21-8-7-19(14-22(21)43-27(31,32)33)40-11-9-39(10-12-40)16(2)41/h3-8,13-15H,1,9-12H2,2H3,(H,35,42)(H2,34,36,37,38)
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Celgene CAR LLC

US Patent


Assay Description
Briefly, 10× stocks of EGFR-WT (PV3872) from Invitrogen and EGFR-T790M/L858R (40350) from BPS Bioscience, San Diego, Calif., 1.13×ATP (AS001A) and ap...


US Patent US10434101 (2019)


BindingDB Entry DOI: 10.7270/Q2NK3HD3
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM149426
PNG
(US10434101, Compound I-28 | US8975249, I-28)
Show SMILES CNC(=O)N1CCN(CC1)c1ccc(Nc2ncc(c(Nc3cccc(NC(=O)C=C)c3)n2)C(F)(F)F)c(OC)c1
Show InChI InChI=1S/C27H29F3N8O3/c1-4-23(39)33-17-6-5-7-18(14-17)34-24-20(27(28,29)30)16-32-25(36-24)35-21-9-8-19(15-22(21)41-3)37-10-12-38(13-11-37)26(40)31-2/h4-9,14-16H,1,10-13H2,2-3H3,(H,31,40)(H,33,39)(H2,32,34,35,36)
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Celgene CAR LLC

US Patent


Assay Description
Briefly, 10× stocks of EGFR-WT (PV3872) from Invitrogen and EGFR-T790M/L858R (40350) from BPS Bioscience, San Diego, Calif., 1.13×ATP (AS001A) and ap...


US Patent US10434101 (2019)


BindingDB Entry DOI: 10.7270/Q2NK3HD3
More data for this
Ligand-Target Pair
Epidermal growth factor receptor(L858R, T790M)


(Homo sapiens (Human))
BDBM149423
PNG
(US10434101, Compound I-24 | US8975249, I-24)
Show SMILES COc1cc(ccc1Nc1ncc(Cl)c(Oc2cccc(NC(=O)C=C)c2)n1)N1CCN(CC1)C(=O)C(F)(F)F
Show InChI InChI=1S/C26H24ClF3N6O4/c1-3-22(37)32-16-5-4-6-18(13-16)40-23-19(27)15-31-25(34-23)33-20-8-7-17(14-21(20)39-2)35-9-11-36(12-10-35)24(38)26(28,29)30/h3-8,13-15H,1,9-12H2,2H3,(H,32,37)(H,31,33,34)
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Celgene CAR LLC

US Patent


Assay Description
Briefly, 10× stocks of EGFR-WT (PV3872) from Invitrogen and EGFR-T790M/L858R (40350) from BPS Bioscience, San Diego, Calif., 1.13×ATP (AS001A) and ap...


US Patent US10434101 (2019)


BindingDB Entry DOI: 10.7270/Q2NK3HD3
More data for this
Ligand-Target Pair
Epidermal growth factor receptor(L858R, T790M)


(Homo sapiens (Human))
BDBM149422
PNG
(US10434101, Compound I-23 | US8975249, I-23)
Show SMILES COc1cc(ccc1Nc1ncc(Cl)c(Oc2cccc(NC(=O)C=C)c2)n1)N1CCN(CC1)C(=O)CC(C)(C)C
Show InChI InChI=1S/C30H35ClN6O4/c1-6-26(38)33-20-8-7-9-22(16-20)41-28-23(31)19-32-29(35-28)34-24-11-10-21(17-25(24)40-5)36-12-14-37(15-13-36)27(39)18-30(2,3)4/h6-11,16-17,19H,1,12-15,18H2,2-5H3,(H,33,38)(H,32,34,35)
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Celgene CAR LLC

US Patent


Assay Description
Briefly, 10× stocks of EGFR-WT (PV3872) from Invitrogen and EGFR-T790M/L858R (40350) from BPS Bioscience, San Diego, Calif., 1.13×ATP (AS001A) and ap...


US Patent US10434101 (2019)


BindingDB Entry DOI: 10.7270/Q2NK3HD3
More data for this
Ligand-Target Pair
Epidermal growth factor receptor(L858R, T790M)


(Homo sapiens (Human))
BDBM414438
PNG
(US10434101, Compound I-15)
Show SMILES COc1cc(ccc1Nc1ncc(Cl)c(Nc2cccc(NC(=O)C=C)c2)n1)N1CCOCC1
Show InChI InChI=1S/C24H25ClN6O3/c1-3-22(32)27-16-5-4-6-17(13-16)28-23-19(25)15-26-24(30-23)29-20-8-7-18(14-21(20)33-2)31-9-11-34-12-10-31/h3-8,13-15H,1,9-12H2,2H3,(H,27,32)(H2,26,28,29,30)
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n/an/a 5.5n/an/an/an/an/an/a



Celgene CAR LLC

US Patent


Assay Description
Briefly, 10× stocks of EGFR-WT (PV3872) from Invitrogen and EGFR-T790M/L858R (40350) from BPS Bioscience, San Diego, Calif., 1.13×ATP (AS001A) and ap...


US Patent US10434101 (2019)


BindingDB Entry DOI: 10.7270/Q2NK3HD3
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM149425
PNG
(US10434101, Compound I-27 | US8975249, I-27)
Show SMILES COc1cc(ccc1Nc1ncc(c(Oc2cccc(NC(=O)C=C)c2)n1)C(F)(F)F)N1CCN(CC1)S(N)(=O)=O
Show InChI InChI=1S/C25H26F3N7O5S/c1-3-22(36)31-16-5-4-6-18(13-16)40-23-19(25(26,27)28)15-30-24(33-23)32-20-8-7-17(14-21(20)39-2)34-9-11-35(12-10-34)41(29,37)38/h3-8,13-15H,1,9-12H2,2H3,(H,31,36)(H2,29,37,38)(H,30,32,33)
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Celgene CAR LLC

US Patent


Assay Description
Briefly, 10× stocks of EGFR-WT (PV3872) from Invitrogen and EGFR-T790M/L858R (40350) from BPS Bioscience, San Diego, Calif., 1.13×ATP (AS001A) and ap...


US Patent US10434101 (2019)


BindingDB Entry DOI: 10.7270/Q2NK3HD3
More data for this
Ligand-Target Pair
Epidermal growth factor receptor(L858R, T790M)


(Homo sapiens (Human))
BDBM149408
PNG
(US10434101, Compound I-8 | US8975249, I-8 | US9796...)
Show SMILES COc1cc(ccc1Nc1ncc(Cl)c(Nc2cccc(NC(=O)C=C)c2)n1)N1CCN(CC1)C(C)=O
Show InChI InChI=1S/C26H28ClN7O3/c1-4-24(36)29-18-6-5-7-19(14-18)30-25-21(27)16-28-26(32-25)31-22-9-8-20(15-23(22)37-3)34-12-10-33(11-13-34)17(2)35/h4-9,14-16H,1,10-13H2,2-3H3,(H,29,36)(H2,28,30,31,32)
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Celgene CAR LLC

US Patent


Assay Description
Briefly, 10× stocks of EGFR-WT (PV3872) from Invitrogen and EGFR-T790M/L858R (40350) from BPS Bioscience, San Diego, Calif., 1.13×ATP (AS001A) and ap...


US Patent US10434101 (2019)


BindingDB Entry DOI: 10.7270/Q2NK3HD3
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM149407
PNG
(US10434101, Compound I-7 | US8975249, I-7)
Show SMILES COc1cc(ccc1Nc1ncc(c(Nc2cccc(NC(=O)C=C)c2)n1)C(F)(F)F)N1CCCN(CC1)C(C)=O
Show InChI InChI=1S/C28H30F3N7O3/c1-4-25(40)33-19-7-5-8-20(15-19)34-26-22(28(29,30)31)17-32-27(36-26)35-23-10-9-21(16-24(23)41-3)38-12-6-11-37(13-14-38)18(2)39/h4-5,7-10,15-17H,1,6,11-14H2,2-3H3,(H,33,40)(H2,32,34,35,36)
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Celgene CAR LLC

US Patent


Assay Description
Briefly, 10× stocks of EGFR-WT (PV3872) from Invitrogen and EGFR-T790M/L858R (40350) from BPS Bioscience, San Diego, Calif., 1.13×ATP (AS001A) and ap...


US Patent US10434101 (2019)


BindingDB Entry DOI: 10.7270/Q2NK3HD3
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM149411
PNG
(US10434101, Compound I-11 | US8975249, I-11)
Show SMILES COc1cc(ccc1Nc1ncc(c(Oc2cccc(NC(=O)C=C)c2)n1)C(F)(F)F)N1CCN(CC1)C(=O)CO
Show InChI InChI=1S/C27H27F3N6O5/c1-3-23(38)32-17-5-4-6-19(13-17)41-25-20(27(28,29)30)15-31-26(34-25)33-21-8-7-18(14-22(21)40-2)35-9-11-36(12-10-35)24(39)16-37/h3-8,13-15,37H,1,9-12,16H2,2H3,(H,32,38)(H,31,33,34)
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Celgene CAR LLC

US Patent


Assay Description
Briefly, 10× stocks of EGFR-WT (PV3872) from Invitrogen and EGFR-T790M/L858R (40350) from BPS Bioscience, San Diego, Calif., 1.13×ATP (AS001A) and ap...


US Patent US10434101 (2019)


BindingDB Entry DOI: 10.7270/Q2NK3HD3
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM149412
PNG
(US10434101, Compound I-12 | US8975249, I-12)
Show SMILES COc1cc(ccc1Nc1ncc(Cl)c(Nc2cccc(NC(=O)C=C)c2)n1)N1CCN(CC1)C(=O)CO
Show InChI InChI=1S/C26H28ClN7O4/c1-3-23(36)29-17-5-4-6-18(13-17)30-25-20(27)15-28-26(32-25)31-21-8-7-19(14-22(21)38-2)33-9-11-34(12-10-33)24(37)16-35/h3-8,13-15,35H,1,9-12,16H2,2H3,(H,29,36)(H2,28,30,31,32)
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Celgene CAR LLC

US Patent


Assay Description
Briefly, 10× stocks of EGFR-WT (PV3872) from Invitrogen and EGFR-T790M/L858R (40350) from BPS Bioscience, San Diego, Calif., 1.13×ATP (AS001A) and ap...


US Patent US10434101 (2019)


BindingDB Entry DOI: 10.7270/Q2NK3HD3
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM149436
PNG
(US10434101, Compound I-38 | US8975249, I-38)
Show SMILES COc1cc(ccc1Nc1ncc(c(Nc2cccc(NC(=O)C=C)c2)n1)C(F)(F)F)N1CCCOCC1
Show InChI InChI=1S/C26H27F3N6O3/c1-3-23(36)31-17-6-4-7-18(14-17)32-24-20(26(27,28)29)16-30-25(34-24)33-21-9-8-19(15-22(21)37-2)35-10-5-12-38-13-11-35/h3-4,6-9,14-16H,1,5,10-13H2,2H3,(H,31,36)(H2,30,32,33,34)
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Celgene CAR LLC

US Patent


Assay Description
Briefly, 10× stocks of EGFR-WT (PV3872) from Invitrogen and EGFR-T790M/L858R (40350) from BPS Bioscience, San Diego, Calif., 1.13×ATP (AS001A) and ap...


US Patent US10434101 (2019)


BindingDB Entry DOI: 10.7270/Q2NK3HD3
More data for this
Ligand-Target Pair
Epidermal growth factor receptor(L858R, T790M)


(Homo sapiens (Human))
BDBM414460
PNG
(US10434101, Compound I-39)
Show SMILES COc1cc(ccc1Nc1ncc(c(Oc2cccc(NC(=O)C=C)c2)n1)C(F)(F)F)N1CCCN(CC1)C(=O)OC(C)(C)C
Show InChI InChI=1S/C31H35F3N6O5/c1-6-26(41)36-20-9-7-10-22(17-20)44-27-23(31(32,33)34)19-35-28(38-27)37-24-12-11-21(18-25(24)43-5)39-13-8-14-40(16-15-39)29(42)45-30(2,3)4/h6-7,9-12,17-19H,1,8,13-16H2,2-5H3,(H,36,41)(H,35,37,38)
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Celgene CAR LLC

US Patent


Assay Description
Briefly, 10× stocks of EGFR-WT (PV3872) from Invitrogen and EGFR-T790M/L858R (40350) from BPS Bioscience, San Diego, Calif., 1.13×ATP (AS001A) and ap...


US Patent US10434101 (2019)


BindingDB Entry DOI: 10.7270/Q2NK3HD3
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM149402
PNG
(US10434101, Compound I-2 | US8975249, I-2)
Show SMILES COc1cc(ccc1Nc1ncc(c(Nc2cccc(NC(=O)C=C)c2)n1)C(F)(F)F)N1CCOCC1
Show InChI InChI=1S/C25H25F3N6O3/c1-3-22(35)30-16-5-4-6-17(13-16)31-23-19(25(26,27)28)15-29-24(33-23)32-20-8-7-18(14-21(20)36-2)34-9-11-37-12-10-34/h3-8,13-15H,1,9-12H2,2H3,(H,30,35)(H2,29,31,32,33)
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Celgene CAR LLC

US Patent


Assay Description
Briefly, 10× stocks of EGFR-WT (PV3872) from Invitrogen and EGFR-T790M/L858R (40350) from BPS Bioscience, San Diego, Calif., 1.13×ATP (AS001A) and ap...


US Patent US10434101 (2019)


BindingDB Entry DOI: 10.7270/Q2NK3HD3
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM149416
PNG
(US10434101, Compound I-17 | US8975249, I-17)
Show SMILES COc1cc(ccc1Nc1ncc(c(Nc2cccc(NC(=O)C=C)c2)n1)C(F)(F)F)N1CCN(CC1)S(C)(=O)=O
Show InChI InChI=1S/C26H28F3N7O4S/c1-4-23(37)31-17-6-5-7-18(14-17)32-24-20(26(27,28)29)16-30-25(34-24)33-21-9-8-19(15-22(21)40-2)35-10-12-36(13-11-35)41(3,38)39/h4-9,14-16H,1,10-13H2,2-3H3,(H,31,37)(H2,30,32,33,34)
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Celgene CAR LLC

US Patent


Assay Description
Briefly, 10× stocks of EGFR-WT (PV3872) from Invitrogen and EGFR-T790M/L858R (40350) from BPS Bioscience, San Diego, Calif., 1.13×ATP (AS001A) and ap...


US Patent US10434101 (2019)


BindingDB Entry DOI: 10.7270/Q2NK3HD3
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM149419
PNG
(US10434101, Compound I-20 | US8975249, I-20)
Show SMILES COC(=O)N1CCN(CC1)c1ccc(Nc2ncc(c(Oc3cccc(NC(=O)C=C)c3)n2)C(F)(F)F)c(OC)c1
Show InChI InChI=1S/C27H27F3N6O5/c1-4-23(37)32-17-6-5-7-19(14-17)41-24-20(27(28,29)30)16-31-25(34-24)33-21-9-8-18(15-22(21)39-2)35-10-12-36(13-11-35)26(38)40-3/h4-9,14-16H,1,10-13H2,2-3H3,(H,32,37)(H,31,33,34)
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Celgene CAR LLC

US Patent


Assay Description
Briefly, 10× stocks of EGFR-WT (PV3872) from Invitrogen and EGFR-T790M/L858R (40350) from BPS Bioscience, San Diego, Calif., 1.13×ATP (AS001A) and ap...


US Patent US10434101 (2019)


BindingDB Entry DOI: 10.7270/Q2NK3HD3
More data for this
Ligand-Target Pair
Epidermal growth factor receptor(L858R, T790M)


(Homo sapiens (Human))
BDBM149445
PNG
(US10434101, Compound I-47 | US8975249, I-47)
Show SMILES CC(C)(C)OC(=O)N1CCN(CC1)c1ccc(Nc2ncc(Cl)c(Oc3cccc(NC(=O)C=C)c3)n2)c(OC(F)(F)F)c1
Show InChI InChI=1S/C29H30ClF3N6O5/c1-5-24(40)35-18-7-6-8-20(15-18)42-25-21(30)17-34-26(37-25)36-22-10-9-19(16-23(22)43-29(31,32)33)38-11-13-39(14-12-38)27(41)44-28(2,3)4/h5-10,15-17H,1,11-14H2,2-4H3,(H,35,40)(H,34,36,37)
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Celgene CAR LLC

US Patent


Assay Description
Briefly, 10× stocks of EGFR-WT (PV3872) from Invitrogen and EGFR-T790M/L858R (40350) from BPS Bioscience, San Diego, Calif., 1.13×ATP (AS001A) and ap...


US Patent US10434101 (2019)


BindingDB Entry DOI: 10.7270/Q2NK3HD3
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM149427
PNG
(US10434101, Compound I-29 | US8975249, I-29)
Show SMILES COC(=O)N1CCN(CC1)c1ccc(Nc2ncc(c(Nc3cccc(NC(=O)C=C)c3)n2)C(F)(F)F)c(OC)c1
Show InChI InChI=1S/C27H28F3N7O4/c1-4-23(38)32-17-6-5-7-18(14-17)33-24-20(27(28,29)30)16-31-25(35-24)34-21-9-8-19(15-22(21)40-2)36-10-12-37(13-11-36)26(39)41-3/h4-9,14-16H,1,10-13H2,2-3H3,(H,32,38)(H2,31,33,34,35)
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Celgene CAR LLC

US Patent


Assay Description
Briefly, 10× stocks of EGFR-WT (PV3872) from Invitrogen and EGFR-T790M/L858R (40350) from BPS Bioscience, San Diego, Calif., 1.13×ATP (AS001A) and ap...


US Patent US10434101 (2019)


BindingDB Entry DOI: 10.7270/Q2NK3HD3
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM149414
PNG
(US10434101, Compound I-14 | US8975249, I-14)
Show SMILES FC(F)Oc1cc(ccc1Nc1ncc(c(Nc2cccc(NC(=O)C=C)c2)n1)C(F)(F)F)N1CCOCC1
Show InChI InChI=1S/C25H23F5N6O3/c1-2-21(37)32-15-4-3-5-16(12-15)33-22-18(25(28,29)30)14-31-24(35-22)34-19-7-6-17(13-20(19)39-23(26)27)36-8-10-38-11-9-36/h2-7,12-14,23H,1,8-11H2,(H,32,37)(H2,31,33,34,35)
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Celgene CAR LLC

US Patent


Assay Description
Briefly, 10× stocks of EGFR-WT (PV3872) from Invitrogen and EGFR-T790M/L858R (40350) from BPS Bioscience, San Diego, Calif., 1.13×ATP (AS001A) and ap...


US Patent US10434101 (2019)


BindingDB Entry DOI: 10.7270/Q2NK3HD3
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM149420
PNG
(US10434101, Compound I-21 | US8975249, I-21)
Show SMILES CNC(=O)N1CCN(CC1)c1ccc(Nc2ncc(c(Oc3cccc(NC(=O)C=C)c3)n2)C(F)(F)F)c(OC)c1
Show InChI InChI=1S/C27H28F3N7O4/c1-4-23(38)33-17-6-5-7-19(14-17)41-24-20(27(28,29)30)16-32-25(35-24)34-21-9-8-18(15-22(21)40-3)36-10-12-37(13-11-36)26(39)31-2/h4-9,14-16H,1,10-13H2,2-3H3,(H,31,39)(H,33,38)(H,32,34,35)
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Celgene CAR LLC

US Patent


Assay Description
Briefly, 10× stocks of EGFR-WT (PV3872) from Invitrogen and EGFR-T790M/L858R (40350) from BPS Bioscience, San Diego, Calif., 1.13×ATP (AS001A) and ap...


US Patent US10434101 (2019)


BindingDB Entry DOI: 10.7270/Q2NK3HD3
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM149408
PNG
(US10434101, Compound I-8 | US8975249, I-8 | US9796...)
Show SMILES COc1cc(ccc1Nc1ncc(Cl)c(Nc2cccc(NC(=O)C=C)c2)n1)N1CCN(CC1)C(C)=O
Show InChI InChI=1S/C26H28ClN7O3/c1-4-24(36)29-18-6-5-7-19(14-18)30-25-21(27)16-28-26(32-25)31-22-9-8-20(15-23(22)37-3)34-12-10-33(11-13-34)17(2)35/h4-9,14-16H,1,10-13H2,2-3H3,(H,29,36)(H2,28,30,31,32)
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Celgene CAR LLC

US Patent


Assay Description
Briefly, 10× stocks of EGFR-WT (PV3872) from Invitrogen and EGFR-T790M/L858R (40350) from BPS Bioscience, San Diego, Calif., 1.13×ATP (AS001A) and ap...


US Patent US10434101 (2019)


BindingDB Entry DOI: 10.7270/Q2NK3HD3
More data for this
Ligand-Target Pair
Epidermal growth factor receptor(L858R, T790M)


(Homo sapiens (Human))
BDBM149417
PNG
(US10434101, Compound I-18 | US8975249, I-18)
Show SMILES CCOc1cc(ccc1Nc1ncc(Cl)c(Oc2cccc(NC(=O)C=C)c2)n1)N1CCN(CC1)C(=O)OC(C)(C)C
Show InChI InChI=1S/C30H35ClN6O5/c1-6-26(38)33-20-9-8-10-22(17-20)41-27-23(31)19-32-28(35-27)34-24-12-11-21(18-25(24)40-7-2)36-13-15-37(16-14-36)29(39)42-30(3,4)5/h6,8-12,17-19H,1,7,13-16H2,2-5H3,(H,33,38)(H,32,34,35)
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Celgene CAR LLC

US Patent


Assay Description
Briefly, 10× stocks of EGFR-WT (PV3872) from Invitrogen and EGFR-T790M/L858R (40350) from BPS Bioscience, San Diego, Calif., 1.13×ATP (AS001A) and ap...


US Patent US10434101 (2019)


BindingDB Entry DOI: 10.7270/Q2NK3HD3
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM149405
PNG
(US10434101, Compound I-5 | US8975249, I-15 | US897...)
Show SMILES COc1cc(ccc1Nc1ncc(Cl)c(Oc2cccc(NC(=O)C=C)c2)n1)N1CCOCC1
Show InChI InChI=1S/C24H24ClN5O4/c1-3-22(31)27-16-5-4-6-18(13-16)34-23-19(25)15-26-24(29-23)28-20-8-7-17(14-21(20)32-2)30-9-11-33-12-10-30/h3-8,13-15H,1,9-12H2,2H3,(H,27,31)(H,26,28,29)
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Celgene CAR LLC

US Patent


Assay Description
Briefly, 10× stocks of EGFR-WT (PV3872) from Invitrogen and EGFR-T790M/L858R (40350) from BPS Bioscience, San Diego, Calif., 1.13×ATP (AS001A) and ap...


US Patent US10434101 (2019)


BindingDB Entry DOI: 10.7270/Q2NK3HD3
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM149424
PNG
(US10434101, Compound I-26 | US8975249, I-26)
Show SMILES COc1cc(ccc1Nc1ncc(Cl)c(Oc2cccc(NC(=O)C=C)c2)n1)N1CCN(CC1)S(C)(=O)=O
Show InChI InChI=1S/C25H27ClN6O5S/c1-4-23(33)28-17-6-5-7-19(14-17)37-24-20(26)16-27-25(30-24)29-21-9-8-18(15-22(21)36-2)31-10-12-32(13-11-31)38(3,34)35/h4-9,14-16H,1,10-13H2,2-3H3,(H,28,33)(H,27,29,30)
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Celgene CAR LLC

US Patent


Assay Description
Briefly, 10× stocks of EGFR-WT (PV3872) from Invitrogen and EGFR-T790M/L858R (40350) from BPS Bioscience, San Diego, Calif., 1.13×ATP (AS001A) and ap...


US Patent US10434101 (2019)


BindingDB Entry DOI: 10.7270/Q2NK3HD3
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM149434
PNG
(US10434101, Compound I-36 | US8975249, I-36)
Show SMILES FC(F)Oc1cc(ccc1Nc1ncc(Cl)c(Oc2cccc(NC(=O)C=C)c2)n1)N1CCOCC1
Show InChI InChI=1S/C24H22ClF2N5O4/c1-2-21(33)29-15-4-3-5-17(12-15)35-22-18(25)14-28-24(31-22)30-19-7-6-16(13-20(19)36-23(26)27)32-8-10-34-11-9-32/h2-7,12-14,23H,1,8-11H2,(H,29,33)(H,28,30,31)
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Celgene CAR LLC

US Patent


Assay Description
Briefly, 10× stocks of EGFR-WT (PV3872) from Invitrogen and EGFR-T790M/L858R (40350) from BPS Bioscience, San Diego, Calif., 1.13×ATP (AS001A) and ap...


US Patent US10434101 (2019)


BindingDB Entry DOI: 10.7270/Q2NK3HD3
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM149438
PNG
(US10434101, Compound I-40 | US8975249, I-40)
Show SMILES COc1cc(ccc1Nc1ncc(Br)c(Nc2cccc(NC(=O)C=C)c2)n1)N1CCN(CC1)C(C)=O
Show InChI InChI=1S/C26H28BrN7O3/c1-4-24(36)29-18-6-5-7-19(14-18)30-25-21(27)16-28-26(32-25)31-22-9-8-20(15-23(22)37-3)34-12-10-33(11-13-34)17(2)35/h4-9,14-16H,1,10-13H2,2-3H3,(H,29,36)(H2,28,30,31,32)
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Celgene CAR LLC

US Patent


Assay Description
Briefly, 10× stocks of EGFR-WT (PV3872) from Invitrogen and EGFR-T790M/L858R (40350) from BPS Bioscience, San Diego, Calif., 1.13×ATP (AS001A) and ap...


US Patent US10434101 (2019)


BindingDB Entry DOI: 10.7270/Q2NK3HD3
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM149446
PNG
(US10434101, Compound I-48 | US8975249, I-48)
Show SMILES COC(=O)[C@@H]1CN(CCN1C(C)=O)c1ccc(Nc2ncc(c(Nc3cccc(NC(=O)C=C)c3)n2)C(F)(F)F)c(OC)c1
Show InChI InChI=1S/C29H30F3N7O5/c1-5-25(41)34-18-7-6-8-19(13-18)35-26-21(29(30,31)32)15-33-28(37-26)36-22-10-9-20(14-24(22)43-3)38-11-12-39(17(2)40)23(16-38)27(42)44-4/h5-10,13-15,23H,1,11-12,16H2,2-4H3,(H,34,41)(H2,33,35,36,37)/t23-/m0/s1
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Celgene CAR LLC

US Patent


Assay Description
Briefly, 10× stocks of EGFR-WT (PV3872) from Invitrogen and EGFR-T790M/L858R (40350) from BPS Bioscience, San Diego, Calif., 1.13×ATP (AS001A) and ap...


US Patent US10434101 (2019)


BindingDB Entry DOI: 10.7270/Q2NK3HD3
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM149435
PNG
(US10434101, Compound I-37 | US8975249, I-37)
Show SMILES COc1cc(ccc1Nc1ncc(Cl)c(Oc2cccc(NC(=O)C=C)c2)n1)N1CCCOCC1
Show InChI InChI=1S/C25H26ClN5O4/c1-3-23(32)28-17-6-4-7-19(14-17)35-24-20(26)16-27-25(30-24)29-21-9-8-18(15-22(21)33-2)31-10-5-12-34-13-11-31/h3-4,6-9,14-16H,1,5,10-13H2,2H3,(H,28,32)(H,27,29,30)
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Celgene CAR LLC

US Patent


Assay Description
Briefly, 10× stocks of EGFR-WT (PV3872) from Invitrogen and EGFR-T790M/L858R (40350) from BPS Bioscience, San Diego, Calif., 1.13×ATP (AS001A) and ap...


US Patent US10434101 (2019)


BindingDB Entry DOI: 10.7270/Q2NK3HD3
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM149423
PNG
(US10434101, Compound I-24 | US8975249, I-24)
Show SMILES COc1cc(ccc1Nc1ncc(Cl)c(Oc2cccc(NC(=O)C=C)c2)n1)N1CCN(CC1)C(=O)C(F)(F)F
Show InChI InChI=1S/C26H24ClF3N6O4/c1-3-22(37)32-16-5-4-6-18(13-16)40-23-19(27)15-31-25(34-23)33-20-8-7-17(14-21(20)39-2)35-9-11-36(12-10-35)24(38)26(28,29)30/h3-8,13-15H,1,9-12H2,2H3,(H,32,37)(H,31,33,34)
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Celgene CAR LLC

US Patent


Assay Description
Briefly, 10× stocks of EGFR-WT (PV3872) from Invitrogen and EGFR-T790M/L858R (40350) from BPS Bioscience, San Diego, Calif., 1.13×ATP (AS001A) and ap...


US Patent US10434101 (2019)


BindingDB Entry DOI: 10.7270/Q2NK3HD3
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM149439
PNG
(US10434101, Compound I-41 | US8975249, I-41)
Show SMILES COc1cc(ccc1Nc1ncc(Cl)c(Nc2cccc(NC(=O)C=C)c2)n1)N1CCN(CC1)S(C)(=O)=O
Show InChI InChI=1S/C25H28ClN7O4S/c1-4-23(34)28-17-6-5-7-18(14-17)29-24-20(26)16-27-25(31-24)30-21-9-8-19(15-22(21)37-2)32-10-12-33(13-11-32)38(3,35)36/h4-9,14-16H,1,10-13H2,2-3H3,(H,28,34)(H2,27,29,30,31)
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Celgene CAR LLC

US Patent


Assay Description
Briefly, 10× stocks of EGFR-WT (PV3872) from Invitrogen and EGFR-T790M/L858R (40350) from BPS Bioscience, San Diego, Calif., 1.13×ATP (AS001A) and ap...


US Patent US10434101 (2019)


BindingDB Entry DOI: 10.7270/Q2NK3HD3
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM149421
PNG
(US10434101, Compound I-22 | US8975249, I-22)
Show SMILES COc1cc(ccc1Nc1ncc(c(Oc2cccc(NC(=O)C=C)c2)n1)C(F)(F)F)N1CCN(CC1)S(C)(=O)=O
Show InChI InChI=1S/C26H27F3N6O5S/c1-4-23(36)31-17-6-5-7-19(14-17)40-24-20(26(27,28)29)16-30-25(33-24)32-21-9-8-18(15-22(21)39-2)34-10-12-35(13-11-34)41(3,37)38/h4-9,14-16H,1,10-13H2,2-3H3,(H,31,36)(H,30,32,33)
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Celgene CAR LLC

US Patent


Assay Description
Briefly, 10× stocks of EGFR-WT (PV3872) from Invitrogen and EGFR-T790M/L858R (40350) from BPS Bioscience, San Diego, Calif., 1.13×ATP (AS001A) and ap...


US Patent US10434101 (2019)


BindingDB Entry DOI: 10.7270/Q2NK3HD3
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM149443
PNG
(US10434101, Compound I-45 | US8975249, I-45)
Show SMILES COc1cc(ccc1Nc1ncc(c(Nc2cccc(NC(=O)C=C)c2)n1)C(F)(F)F)N1CCN(CC1)C(=O)CC(C)(C)C
Show InChI InChI=1S/C31H36F3N7O3/c1-6-26(42)36-20-8-7-9-21(16-20)37-28-23(31(32,33)34)19-35-29(39-28)38-24-11-10-22(17-25(24)44-5)40-12-14-41(15-13-40)27(43)18-30(2,3)4/h6-11,16-17,19H,1,12-15,18H2,2-5H3,(H,36,42)(H2,35,37,38,39)
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Celgene CAR LLC

US Patent


Assay Description
Briefly, 10× stocks of EGFR-WT (PV3872) from Invitrogen and EGFR-T790M/L858R (40350) from BPS Bioscience, San Diego, Calif., 1.13×ATP (AS001A) and ap...


US Patent US10434101 (2019)


BindingDB Entry DOI: 10.7270/Q2NK3HD3
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM149401
PNG
(US10434101, Compound I-1 | US8975249, I-1)
Show SMILES COc1cc(ccc1Nc1ncc(c(Oc2cccc(NC(=O)C=C)c2)n1)C(F)(F)F)N1CCOCC1
Show InChI InChI=1S/C25H24F3N5O4/c1-3-22(34)30-16-5-4-6-18(13-16)37-23-19(25(26,27)28)15-29-24(32-23)31-20-8-7-17(14-21(20)35-2)33-9-11-36-12-10-33/h3-8,13-15H,1,9-12H2,2H3,(H,30,34)(H,29,31,32)
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n/an/a 65n/an/an/an/an/an/a



Celgene CAR LLC

US Patent


Assay Description
Briefly, 10× stocks of EGFR-WT (PV3872) from Invitrogen and EGFR-T790M/L858R (40350) from BPS Bioscience, San Diego, Calif., 1.13×ATP (AS001A) and ap...


US Patent US10434101 (2019)


BindingDB Entry DOI: 10.7270/Q2NK3HD3
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM149432
PNG
(US10434101, Compound I-34 | US8975249, I-34)
Show SMILES COc1cc(ccc1Nc1ncc(c(Nc2cccc(NC(=O)C=C)c2)n1)C(F)(F)F)N1CCN(CC1)C(=O)C(C)(C)C
Show InChI InChI=1S/C30H34F3N7O3/c1-6-25(41)35-19-8-7-9-20(16-19)36-26-22(30(31,32)33)18-34-28(38-26)37-23-11-10-21(17-24(23)43-5)39-12-14-40(15-13-39)27(42)29(2,3)4/h6-11,16-18H,1,12-15H2,2-5H3,(H,35,41)(H2,34,36,37,38)
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Celgene CAR LLC

US Patent


Assay Description
Briefly, 10× stocks of EGFR-WT (PV3872) from Invitrogen and EGFR-T790M/L858R (40350) from BPS Bioscience, San Diego, Calif., 1.13×ATP (AS001A) and ap...


US Patent US10434101 (2019)


BindingDB Entry DOI: 10.7270/Q2NK3HD3
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM149428
PNG
(US10434101, Compound I-30 | US8975249, I-30)
Show SMILES OCC(=O)N1CCN(CC1)c1ccc(Nc2ncc(c(Nc3cccc(NC(=O)C=C)c3)n2)C(F)(F)F)c(OC(F)(F)F)c1
Show InChI InChI=1S/C27H25F6N7O4/c1-2-22(42)35-16-4-3-5-17(12-16)36-24-19(26(28,29)30)14-34-25(38-24)37-20-7-6-18(13-21(20)44-27(31,32)33)39-8-10-40(11-9-39)23(43)15-41/h2-7,12-14,41H,1,8-11,15H2,(H,35,42)(H2,34,36,37,38)
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Celgene CAR LLC

US Patent


Assay Description
Briefly, 10× stocks of EGFR-WT (PV3872) from Invitrogen and EGFR-T790M/L858R (40350) from BPS Bioscience, San Diego, Calif., 1.13×ATP (AS001A) and ap...


US Patent US10434101 (2019)


BindingDB Entry DOI: 10.7270/Q2NK3HD3
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM414438
PNG
(US10434101, Compound I-15)
Show SMILES COc1cc(ccc1Nc1ncc(Cl)c(Nc2cccc(NC(=O)C=C)c2)n1)N1CCOCC1
Show InChI InChI=1S/C24H25ClN6O3/c1-3-22(32)27-16-5-4-6-17(13-16)28-23-19(25)15-26-24(30-23)29-20-8-7-18(14-21(20)33-2)31-9-11-34-12-10-31/h3-8,13-15H,1,9-12H2,2H3,(H,27,32)(H2,26,28,29,30)
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Celgene CAR LLC

US Patent


Assay Description
Briefly, 10× stocks of EGFR-WT (PV3872) from Invitrogen and EGFR-T790M/L858R (40350) from BPS Bioscience, San Diego, Calif., 1.13×ATP (AS001A) and ap...


US Patent US10434101 (2019)


BindingDB Entry DOI: 10.7270/Q2NK3HD3
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM149413
PNG
(US10434101, Compound I-13 | US8975249, I-13)
Show SMILES FC(F)Oc1cc(ccc1Nc1ncc(c(Oc2cccc(NC(=O)C=C)c2)n1)C(F)(F)F)N1CCOCC1
Show InChI InChI=1S/C25H22F5N5O4/c1-2-21(36)32-15-4-3-5-17(12-15)38-22-18(25(28,29)30)14-31-24(34-22)33-19-7-6-16(13-20(19)39-23(26)27)35-8-10-37-11-9-35/h2-7,12-14,23H,1,8-11H2,(H,32,36)(H,31,33,34)
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Celgene CAR LLC

US Patent


Assay Description
Briefly, 10× stocks of EGFR-WT (PV3872) from Invitrogen and EGFR-T790M/L858R (40350) from BPS Bioscience, San Diego, Calif., 1.13×ATP (AS001A) and ap...


US Patent US10434101 (2019)


BindingDB Entry DOI: 10.7270/Q2NK3HD3
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM149444
PNG
(US10434101, Compound I-46 | US8975249, I-46)
Show SMILES COc1cc(ccc1Nc1ncc(Cl)c(Oc2cccc(NC(=O)C=C)c2)n1)N1CCN(CC1)C(=O)OC(C)(C)C
Show InChI InChI=1S/C29H33ClN6O5/c1-6-25(37)32-19-8-7-9-21(16-19)40-26-22(30)18-31-27(34-26)33-23-11-10-20(17-24(23)39-5)35-12-14-36(15-13-35)28(38)41-29(2,3)4/h6-11,16-18H,1,12-15H2,2-5H3,(H,32,37)(H,31,33,34)
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Celgene CAR LLC

US Patent


Assay Description
Briefly, 10× stocks of EGFR-WT (PV3872) from Invitrogen and EGFR-T790M/L858R (40350) from BPS Bioscience, San Diego, Calif., 1.13×ATP (AS001A) and ap...


US Patent US10434101 (2019)


BindingDB Entry DOI: 10.7270/Q2NK3HD3
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM149418
PNG
(US10434101, Compound I-19 | US8975249, I-19)
Show SMILES COc1cc(ccc1Nc1ncc(c(Nc2cccc(NC(=O)C=C)c2)n1)C(F)(F)F)N1CCCN(CC1)C(=O)C(F)(F)F
Show InChI InChI=1S/C28H27F6N7O3/c1-3-23(42)36-17-6-4-7-18(14-17)37-24-20(27(29,30)31)16-35-26(39-24)38-21-9-8-19(15-22(21)44-2)40-10-5-11-41(13-12-40)25(43)28(32,33)34/h3-4,6-9,14-16H,1,5,10-13H2,2H3,(H,36,42)(H2,35,37,38,39)
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n/an/a 200n/an/an/an/an/an/a



Celgene CAR LLC

US Patent


Assay Description
Briefly, 10× stocks of EGFR-WT (PV3872) from Invitrogen and EGFR-T790M/L858R (40350) from BPS Bioscience, San Diego, Calif., 1.13×ATP (AS001A) and ap...


US Patent US10434101 (2019)


BindingDB Entry DOI: 10.7270/Q2NK3HD3
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM149422
PNG
(US10434101, Compound I-23 | US8975249, I-23)
Show SMILES COc1cc(ccc1Nc1ncc(Cl)c(Oc2cccc(NC(=O)C=C)c2)n1)N1CCN(CC1)C(=O)CC(C)(C)C
Show InChI InChI=1S/C30H35ClN6O4/c1-6-26(38)33-20-8-7-9-22(16-20)41-28-23(31)19-32-29(35-28)34-24-11-10-21(17-25(24)40-5)36-12-14-37(15-13-36)27(39)18-30(2,3)4/h6-11,16-17,19H,1,12-15,18H2,2-5H3,(H,33,38)(H,32,34,35)
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n/an/a 200n/an/an/an/an/an/a



Celgene CAR LLC

US Patent


Assay Description
Briefly, 10× stocks of EGFR-WT (PV3872) from Invitrogen and EGFR-T790M/L858R (40350) from BPS Bioscience, San Diego, Calif., 1.13×ATP (AS001A) and ap...


US Patent US10434101 (2019)


BindingDB Entry DOI: 10.7270/Q2NK3HD3
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM149441
PNG
(US10434101, Compound I-43 | US8975249, I-43)
Show SMILES COc1cc(ccc1Nc1ncc(Cl)c(Oc2cccc(NC(=O)C=C)c2)n1)N1CCCN(CC1)C(=O)OC(C)(C)C
Show InChI InChI=1S/C30H35ClN6O5/c1-6-26(38)33-20-9-7-10-22(17-20)41-27-23(31)19-32-28(35-27)34-24-12-11-21(18-25(24)40-5)36-13-8-14-37(16-15-36)29(39)42-30(2,3)4/h6-7,9-12,17-19H,1,8,13-16H2,2-5H3,(H,33,38)(H,32,34,35)
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n/an/a 650n/an/an/an/an/an/a



Celgene CAR LLC

US Patent


Assay Description
Briefly, 10× stocks of EGFR-WT (PV3872) from Invitrogen and EGFR-T790M/L858R (40350) from BPS Bioscience, San Diego, Calif., 1.13×ATP (AS001A) and ap...


US Patent US10434101 (2019)


BindingDB Entry DOI: 10.7270/Q2NK3HD3
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM149437
PNG
(US10434101, Compound I-44 | US8975249, I-39 | US89...)
Show SMILES COc1cc(ccc1Nc1ncc(c(Nc2cccc(NC(=O)C=C)c2)n1)C(F)(F)F)N1CCCN(CC1)C(=O)OC(C)(C)C
Show InChI InChI=1S/C31H36F3N7O4/c1-6-26(42)36-20-9-7-10-21(17-20)37-27-23(31(32,33)34)19-35-28(39-27)38-24-12-11-22(18-25(24)44-5)40-13-8-14-41(16-15-40)29(43)45-30(2,3)4/h6-7,9-12,17-19H,1,8,13-16H2,2-5H3,(H,36,42)(H2,35,37,38,39)
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n/an/a 650n/an/an/an/an/an/a



Celgene CAR LLC

US Patent


Assay Description
Briefly, 10× stocks of EGFR-WT (PV3872) from Invitrogen and EGFR-T790M/L858R (40350) from BPS Bioscience, San Diego, Calif., 1.13×ATP (AS001A) and ap...


US Patent US10434101 (2019)


BindingDB Entry DOI: 10.7270/Q2NK3HD3
More data for this
Ligand-Target Pair
Epidermal growth factor receptor(L858R, T790M)


(Homo sapiens (Human))
BDBM149440
PNG
(US10434101, Compound I-42 | US8975249, I-42)
Show SMILES COc1cc(ccc1Nc1ncc(c(Oc2cccc(NC(=O)C=C)c2)n1)C(F)(F)F)N1CCN(CC1)C(=O)CC(C)(C)C
Show InChI InChI=1S/C31H35F3N6O4/c1-6-26(41)36-20-8-7-9-22(16-20)44-28-23(31(32,33)34)19-35-29(38-28)37-24-11-10-21(17-25(24)43-5)39-12-14-40(15-13-39)27(42)18-30(2,3)4/h6-11,16-17,19H,1,12-15,18H2,2-5H3,(H,36,41)(H,35,37,38)
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n/an/a 650n/an/an/an/an/an/a



Celgene CAR LLC

US Patent


Assay Description
Briefly, 10× stocks of EGFR-WT (PV3872) from Invitrogen and EGFR-T790M/L858R (40350) from BPS Bioscience, San Diego, Calif., 1.13×ATP (AS001A) and ap...


US Patent US10434101 (2019)


BindingDB Entry DOI: 10.7270/Q2NK3HD3
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM149440
PNG
(US10434101, Compound I-42 | US8975249, I-42)
Show SMILES COc1cc(ccc1Nc1ncc(c(Oc2cccc(NC(=O)C=C)c2)n1)C(F)(F)F)N1CCN(CC1)C(=O)CC(C)(C)C
Show InChI InChI=1S/C31H35F3N6O4/c1-6-26(41)36-20-8-7-9-22(16-20)44-28-23(31(32,33)34)19-35-29(38-28)37-24-11-10-21(17-25(24)43-5)39-12-14-40(15-13-39)27(42)18-30(2,3)4/h6-11,16-17,19H,1,12-15,18H2,2-5H3,(H,36,41)(H,35,37,38)
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n/an/a 650n/an/an/an/an/an/a



Celgene CAR LLC

US Patent


Assay Description
Briefly, 10× stocks of EGFR-WT (PV3872) from Invitrogen and EGFR-T790M/L858R (40350) from BPS Bioscience, San Diego, Calif., 1.13×ATP (AS001A) and ap...


US Patent US10434101 (2019)


BindingDB Entry DOI: 10.7270/Q2NK3HD3
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM149445
PNG
(US10434101, Compound I-47 | US8975249, I-47)
Show SMILES CC(C)(C)OC(=O)N1CCN(CC1)c1ccc(Nc2ncc(Cl)c(Oc3cccc(NC(=O)C=C)c3)n2)c(OC(F)(F)F)c1
Show InChI InChI=1S/C29H30ClF3N6O5/c1-5-24(40)35-18-7-6-8-20(15-18)42-25-21(30)17-34-26(37-25)36-22-10-9-19(16-23(22)43-29(31,32)33)38-11-13-39(14-12-38)27(41)44-28(2,3)4/h5-10,15-17H,1,11-14H2,2-4H3,(H,35,40)(H,34,36,37)
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n/an/a>1.00E+3n/an/an/an/an/an/a



Celgene CAR LLC

US Patent


Assay Description
Briefly, 10× stocks of EGFR-WT (PV3872) from Invitrogen and EGFR-T790M/L858R (40350) from BPS Bioscience, San Diego, Calif., 1.13×ATP (AS001A) and ap...


US Patent US10434101 (2019)


BindingDB Entry DOI: 10.7270/Q2NK3HD3
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM414460
PNG
(US10434101, Compound I-39)
Show SMILES COc1cc(ccc1Nc1ncc(c(Oc2cccc(NC(=O)C=C)c2)n1)C(F)(F)F)N1CCCN(CC1)C(=O)OC(C)(C)C
Show InChI InChI=1S/C31H35F3N6O5/c1-6-26(41)36-20-9-7-10-22(17-20)44-27-23(31(32,33)34)19-35-28(38-27)37-24-12-11-21(18-25(24)43-5)39-13-8-14-40(16-15-39)29(42)45-30(2,3)4/h6-7,9-12,17-19H,1,8,13-16H2,2-5H3,(H,36,41)(H,35,37,38)
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n/an/a>1.00E+3n/an/an/an/an/an/a



Celgene CAR LLC

US Patent


Assay Description
Briefly, 10× stocks of EGFR-WT (PV3872) from Invitrogen and EGFR-T790M/L858R (40350) from BPS Bioscience, San Diego, Calif., 1.13×ATP (AS001A) and ap...


US Patent US10434101 (2019)


BindingDB Entry DOI: 10.7270/Q2NK3HD3
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM149417
PNG
(US10434101, Compound I-18 | US8975249, I-18)
Show SMILES CCOc1cc(ccc1Nc1ncc(Cl)c(Oc2cccc(NC(=O)C=C)c2)n1)N1CCN(CC1)C(=O)OC(C)(C)C
Show InChI InChI=1S/C30H35ClN6O5/c1-6-26(38)33-20-9-8-10-22(17-20)41-27-23(31)19-32-28(35-27)34-24-12-11-21(18-25(24)40-7-2)36-13-15-37(16-14-36)29(39)42-30(3,4)5/h6,8-12,17-19H,1,7,13-16H2,2-5H3,(H,33,38)(H,32,34,35)
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n/an/a>1.00E+3n/an/an/an/an/an/a



Celgene CAR LLC

US Patent


Assay Description
Briefly, 10× stocks of EGFR-WT (PV3872) from Invitrogen and EGFR-T790M/L858R (40350) from BPS Bioscience, San Diego, Calif., 1.13×ATP (AS001A) and ap...


US Patent US10434101 (2019)


BindingDB Entry DOI: 10.7270/Q2NK3HD3
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%