BindingDB logo
myBDB logout

Patent code US10435369

Compile Data Set for Download or QSAR

Found 304 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Nuclear receptor ROR-gamma (RORC)


(Homo sapiens (Human))
BDBM414189
PNG
(US10435369, Example 76)
Show SMILES OC1(CNC(=O)[C@@H]2CC[C@@]3([C@H]2CCc2cc(ccc32)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c2ccc(F)cc2)CCOCC1
Show InChI InChI=1S/C29H29F8NO5S/c30-19-3-5-20(6-4-19)44(41,42)26-10-9-21(24(39)38-16-25(40)11-13-43-14-12-25)23(26)7-1-17-15-18(2-8-22(17)26)27(31,28(32,33)34)29(35,36)37/h2-6,8,15,21,23,40H,1,7,9-14,16H2,(H,38,39)/t21-,23+,26-/m1/s1
PDB

Reactome pathway

UniProtKB/SwissProt
UniProtKB/TrEMBL

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 1n/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
Inverse agonist activity of potential ligands to RORγ was measured by inhibition of luminescence in a Gal4-luciferase reporter assay in Jurkat c...


US Patent US10435369 (2019)


BindingDB Entry DOI: 10.7270/Q21V5HB4
More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma (RORC)


(Homo sapiens (Human))
BDBM414268
PNG
(US10435369, Example 155)
Show SMILES OC1(CCCCC1)C(=O)N[C@@H]1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1
Show InChI InChI=1S/C29H29F8NO4S/c30-19-6-8-20(9-7-19)43(41,42)26-15-12-23(38-24(39)25(40)13-2-1-3-14-25)22(26)10-4-17-16-18(5-11-21(17)26)27(31,28(32,33)34)29(35,36)37/h5-9,11,16,22-23,40H,1-4,10,12-15H2,(H,38,39)/t22-,23+,26+/m0/s1
PDB

Reactome pathway

UniProtKB/SwissProt
UniProtKB/TrEMBL

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 1n/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
Inverse agonist activity of potential ligands to RORγ was measured by inhibition of luminescence in a Gal4-luciferase reporter assay in Jurkat c...


US Patent US10435369 (2019)


BindingDB Entry DOI: 10.7270/Q21V5HB4
More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma (RORC)


(Homo sapiens (Human))
BDBM414283
PNG
(US10435369, Example 170)
Show SMILES CC(C)(N1CCOCC1)C(=O)N[C@H]1CC[C@]2([C@@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1
Show InChI InChI=1S/C30H32F8N2O4S/c1-26(2,40-13-15-44-16-14-40)25(41)39-24-11-12-27(45(42,43)21-7-5-20(31)6-8-21)22-10-4-19(17-18(22)3-9-23(24)27)28(32,29(33,34)35)30(36,37)38/h4-8,10,17,23-24H,3,9,11-16H2,1-2H3,(H,39,41)/t23-,24+,27+/m1/s1
PDB

Reactome pathway

UniProtKB/SwissProt
UniProtKB/TrEMBL

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 2n/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
Inverse agonist activity of potential ligands to RORγ was measured by inhibition of luminescence in a Gal4-luciferase reporter assay in Jurkat c...


US Patent US10435369 (2019)


BindingDB Entry DOI: 10.7270/Q21V5HB4
More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma (RORC)


(Homo sapiens (Human))
BDBM414299
PNG
(US10435369, Example 186)
Show SMILES CC(=O)NC(C)(C)C(=O)N[C@@H]1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1
Show InChI InChI=1S/C28H28F8N2O4S/c1-15(39)38-24(2,3)23(40)37-22-12-13-25(43(41,42)19-8-6-18(29)7-9-19)20-11-5-17(14-16(20)4-10-21(22)25)26(30,27(31,32)33)28(34,35)36/h5-9,11,14,21-22H,4,10,12-13H2,1-3H3,(H,37,40)(H,38,39)/t21-,22+,25+/m0/s1
PDB

Reactome pathway

UniProtKB/SwissProt
UniProtKB/TrEMBL

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 2n/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
Inverse agonist activity of potential ligands to RORγ was measured by inhibition of luminescence in a Gal4-luciferase reporter assay in Jurkat c...


US Patent US10435369 (2019)


BindingDB Entry DOI: 10.7270/Q21V5HB4
More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma (RORC)


(Homo sapiens (Human))
BDBM414358
PNG
(1-(acetyl-d3)-N-((3R,3aS,9bS)-9b-((4-fluorophenyl)...)
Show SMILES CC(=O)N1CCC(O)(CC1)C(=O)N[C@@H]1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1
Show InChI InChI=1S/C30H30F8N2O5S/c1-17(41)40-14-12-26(43,13-15-40)25(42)39-24-10-11-27(46(44,45)21-6-4-20(31)5-7-21)22-9-3-19(16-18(22)2-8-23(24)27)28(32,29(33,34)35)30(36,37)38/h3-7,9,16,23-24,43H,2,8,10-15H2,1H3,(H,39,42)/t23-,24+,27+/m0/s1
PDB

Reactome pathway

UniProtKB/SwissProt
UniProtKB/TrEMBL

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 2n/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
Inverse agonist activity of potential ligands to RORγ was measured by inhibition of luminescence in a Gal4-luciferase reporter assay in Jurkat c...


US Patent US10435369 (2019)


BindingDB Entry DOI: 10.7270/Q21V5HB4
More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma (RORC)


(Homo sapiens (Human))
BDBM414404
PNG
(US10435369, Example 291)
Show SMILES OC1(CCN(CC1)C1COC1)C(=O)N[C@@H]1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1
Show InChI InChI=1S/C31H32F8N2O5S/c32-20-3-5-22(6-4-20)47(44,45)28-10-9-25(40-26(42)27(43)11-13-41(14-12-27)21-16-46-17-21)24(28)7-1-18-15-19(2-8-23(18)28)29(33,30(34,35)36)31(37,38)39/h2-6,8,15,21,24-25,43H,1,7,9-14,16-17H2,(H,40,42)/t24-,25+,28+/m0/s1
PDB

Reactome pathway

UniProtKB/SwissProt
UniProtKB/TrEMBL

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 2n/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
Inverse agonist activity of potential ligands to RORγ was measured by inhibition of luminescence in a Gal4-luciferase reporter assay in Jurkat c...


US Patent US10435369 (2019)


BindingDB Entry DOI: 10.7270/Q21V5HB4
More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma (RORC)


(Homo sapiens (Human))
BDBM414346
PNG
(N-((3R,3aS,9bS)-9b-((4-fluorophenyl)sulfonyl)-7-(p...)
Show SMILES OC(C(=O)N[C@@H]1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1)C1(O)CCOCC1
Show InChI InChI=1S/C29H29F8NO6S/c30-18-3-5-19(6-4-18)45(42,43)26-10-9-22(38-24(40)23(39)25(41)11-13-44-14-12-25)21(26)7-1-16-15-17(2-8-20(16)26)27(31,28(32,33)34)29(35,36)37/h2-6,8,15,21-23,39,41H,1,7,9-14H2,(H,38,40)/t21-,22+,23?,26+/m0/s1
PDB

Reactome pathway

UniProtKB/SwissProt
UniProtKB/TrEMBL

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 2n/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
Inverse agonist activity of potential ligands to RORγ was measured by inhibition of luminescence in a Gal4-luciferase reporter assay in Jurkat c...


US Patent US10435369 (2019)


BindingDB Entry DOI: 10.7270/Q21V5HB4
More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma (RORC)


(Homo sapiens (Human))
BDBM414277
PNG
(US10435369, Example 164)
Show SMILES CC(C)(O)CC(=O)N[C@@H]1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1
Show InChI InChI=1S/C27H27F8NO4S/c1-23(2,38)14-22(37)36-21-11-12-24(41(39,40)18-7-5-17(28)6-8-18)19-10-4-16(13-15(19)3-9-20(21)24)25(29,26(30,31)32)27(33,34)35/h4-8,10,13,20-21,38H,3,9,11-12,14H2,1-2H3,(H,36,37)/t20-,21+,24+/m0/s1
PDB

Reactome pathway

UniProtKB/SwissProt
UniProtKB/TrEMBL

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 2n/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
Inverse agonist activity of potential ligands to RORγ was measured by inhibition of luminescence in a Gal4-luciferase reporter assay in Jurkat c...


US Patent US10435369 (2019)


BindingDB Entry DOI: 10.7270/Q21V5HB4
More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma (RORC)


(Homo sapiens (Human))
BDBM414236
PNG
(US10435369, Example 123 | US10435369, Example 144)
Show SMILES OC1(CCS(=O)(=O)CC1)C(=O)N[C@@H]1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1
Show InChI InChI=1S/C28H27F8NO6S2/c29-18-3-5-19(6-4-18)45(42,43)25-10-9-22(37-23(38)24(39)11-13-44(40,41)14-12-24)21(25)7-1-16-15-17(2-8-20(16)25)26(30,27(31,32)33)28(34,35)36/h2-6,8,15,21-22,39H,1,7,9-14H2,(H,37,38)/t21-,22+,25+/m0/s1
PDB

Reactome pathway

UniProtKB/SwissProt
UniProtKB/TrEMBL

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 2n/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
Inverse agonist activity of potential ligands to RORγ was measured by inhibition of luminescence in a Gal4-luciferase reporter assay in Jurkat c...


US Patent US10435369 (2019)


BindingDB Entry DOI: 10.7270/Q21V5HB4
More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma (RORC)


(Homo sapiens (Human))
BDBM414347
PNG
(US10435369, Example 234)
Show SMILES CC(C)(O)C(O)C(=O)N[C@@H]1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1
Show InChI InChI=1S/C27H27F8NO5S/c1-23(2,39)21(37)22(38)36-20-11-12-24(42(40,41)17-7-5-16(28)6-8-17)18-10-4-15(13-14(18)3-9-19(20)24)25(29,26(30,31)32)27(33,34)35/h4-8,10,13,19-21,37,39H,3,9,11-12H2,1-2H3,(H,36,38)/t19-,20+,21?,24+/m0/s1
PDB

Reactome pathway

UniProtKB/SwissProt
UniProtKB/TrEMBL

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 2n/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
Inverse agonist activity of potential ligands to RORγ was measured by inhibition of luminescence in a Gal4-luciferase reporter assay in Jurkat c...


US Patent US10435369 (2019)


BindingDB Entry DOI: 10.7270/Q21V5HB4
More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma (RORC)


(Homo sapiens (Human))
BDBM414272
PNG
(US10435369, Example 159)
Show SMILES NC(=O)c1c(F)cc(cc1F)C(=O)N[C@@H]1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1
Show InChI InChI=1S/C30H22F10N2O4S/c31-17-3-5-18(6-4-17)47(45,46)27-10-9-23(42-26(44)15-12-21(32)24(25(41)43)22(33)13-15)20(27)7-1-14-11-16(2-8-19(14)27)28(34,29(35,36)37)30(38,39)40/h2-6,8,11-13,20,23H,1,7,9-10H2,(H2,41,43)(H,42,44)/t20-,23+,27+/m0/s1
PDB

Reactome pathway

UniProtKB/SwissProt
UniProtKB/TrEMBL

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 3n/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
Inverse agonist activity of potential ligands to RORγ was measured by inhibition of luminescence in a Gal4-luciferase reporter assay in Jurkat c...


US Patent US10435369 (2019)


BindingDB Entry DOI: 10.7270/Q21V5HB4
More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma (RORC)


(Homo sapiens (Human))
BDBM414294
PNG
(US10435369, Example 181 | US10435369, Example 182)
Show SMILES Fc1ccc(cc1)S(=O)(=O)[C@@]12CC[C@@H](NC(=O)C3CCC(=O)NC3)[C@@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F
Show InChI InChI=1S/C28H26F8N2O4S/c29-18-4-6-19(7-5-18)43(41,42)25-12-11-22(38-24(40)16-2-10-23(39)37-14-16)21(25)8-1-15-13-17(3-9-20(15)25)26(30,27(31,32)33)28(34,35)36/h3-7,9,13,16,21-22H,1-2,8,10-12,14H2,(H,37,39)(H,38,40)/t16?,21-,22+,25+/m0/s1
PDB

Reactome pathway

UniProtKB/SwissProt
UniProtKB/TrEMBL

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 3n/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
Inverse agonist activity of potential ligands to RORγ was measured by inhibition of luminescence in a Gal4-luciferase reporter assay in Jurkat c...


US Patent US10435369 (2019)


BindingDB Entry DOI: 10.7270/Q21V5HB4
More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma (RORC)


(Homo sapiens (Human))
BDBM414399
PNG
(US10435369, Example 286 | US10435369, Example 288)
Show SMILES CN1C[C@H](CC1=O)C(=O)N[C@@H]1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1
Show InChI InChI=1S/C28H26F8N2O4S/c1-38-14-16(13-23(38)39)24(40)37-22-10-11-25(43(41,42)19-6-4-18(29)5-7-19)20-9-3-17(12-15(20)2-8-21(22)25)26(30,27(31,32)33)28(34,35)36/h3-7,9,12,16,21-22H,2,8,10-11,13-14H2,1H3,(H,37,40)/t16-,21-,22+,25+/m0/s1
PDB

Reactome pathway

UniProtKB/SwissProt
UniProtKB/TrEMBL

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 3n/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
Inverse agonist activity of potential ligands to RORγ was measured by inhibition of luminescence in a Gal4-luciferase reporter assay in Jurkat c...


US Patent US10435369 (2019)


BindingDB Entry DOI: 10.7270/Q21V5HB4
More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma (RORC)


(Homo sapiens (Human))
BDBM414399
PNG
(US10435369, Example 286 | US10435369, Example 288)
Show SMILES CN1C[C@H](CC1=O)C(=O)N[C@@H]1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1
Show InChI InChI=1S/C28H26F8N2O4S/c1-38-14-16(13-23(38)39)24(40)37-22-10-11-25(43(41,42)19-6-4-18(29)5-7-19)20-9-3-17(12-15(20)2-8-21(22)25)26(30,27(31,32)33)28(34,35)36/h3-7,9,12,16,21-22H,2,8,10-11,13-14H2,1H3,(H,37,40)/t16-,21-,22+,25+/m0/s1
PDB

Reactome pathway

UniProtKB/SwissProt
UniProtKB/TrEMBL

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 3n/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
Inverse agonist activity of potential ligands to RORγ was measured by inhibition of luminescence in a Gal4-luciferase reporter assay in Jurkat c...


US Patent US10435369 (2019)


BindingDB Entry DOI: 10.7270/Q21V5HB4
More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma (RORC)


(Homo sapiens (Human))
BDBM414316
PNG
(1-((3R,3aS,9bS)-9b-((4-fluorophenyl)sulfonyl)-7-(p...)
Show SMILES CC(C)(O)CNC(=O)N[C@@H]1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1
Show InChI InChI=1S/C27H28F8N2O4S/c1-23(2,39)14-36-22(38)37-21-11-12-24(42(40,41)18-7-5-17(28)6-8-18)19-10-4-16(13-15(19)3-9-20(21)24)25(29,26(30,31)32)27(33,34)35/h4-8,10,13,20-21,39H,3,9,11-12,14H2,1-2H3,(H2,36,37,38)/t20-,21+,24+/m0/s1
PDB

Reactome pathway

UniProtKB/SwissProt
UniProtKB/TrEMBL

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 3n/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
Inverse agonist activity of potential ligands to RORγ was measured by inhibition of luminescence in a Gal4-luciferase reporter assay in Jurkat c...


US Patent US10435369 (2019)


BindingDB Entry DOI: 10.7270/Q21V5HB4
More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma (RORC)


(Homo sapiens (Human))
BDBM414409
PNG
((S)—N-((3R,3aS,9bS)-9b-((4-fluorophenyl)sulfo...)
Show SMILES OCCCN1C[C@H](CC1=O)C(=O)N[C@@H]1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1
Show InChI InChI=1S/C30H30F8N2O5S/c31-20-4-6-21(7-5-20)46(44,45)27-11-10-24(39-26(43)18-15-25(42)40(16-18)12-1-13-41)23(27)8-2-17-14-19(3-9-22(17)27)28(32,29(33,34)35)30(36,37)38/h3-7,9,14,18,23-24,41H,1-2,8,10-13,15-16H2,(H,39,43)/t18-,23-,24+,27+/m0/s1
PDB

Reactome pathway

UniProtKB/SwissProt
UniProtKB/TrEMBL

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 3n/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
Inverse agonist activity of potential ligands to RORγ was measured by inhibition of luminescence in a Gal4-luciferase reporter assay in Jurkat c...


US Patent US10435369 (2019)


BindingDB Entry DOI: 10.7270/Q21V5HB4
More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma (RORC)


(Homo sapiens (Human))
BDBM414294
PNG
(US10435369, Example 181 | US10435369, Example 182)
Show SMILES Fc1ccc(cc1)S(=O)(=O)[C@@]12CC[C@@H](NC(=O)C3CCC(=O)NC3)[C@@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F
Show InChI InChI=1S/C28H26F8N2O4S/c29-18-4-6-19(7-5-18)43(41,42)25-12-11-22(38-24(40)16-2-10-23(39)37-14-16)21(25)8-1-15-13-17(3-9-20(15)25)26(30,27(31,32)33)28(34,35)36/h3-7,9,13,16,21-22H,1-2,8,10-12,14H2,(H,37,39)(H,38,40)/t16?,21-,22+,25+/m0/s1
PDB

Reactome pathway

UniProtKB/SwissProt
UniProtKB/TrEMBL

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 3n/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
Inverse agonist activity of potential ligands to RORγ was measured by inhibition of luminescence in a Gal4-luciferase reporter assay in Jurkat c...


US Patent US10435369 (2019)


BindingDB Entry DOI: 10.7270/Q21V5HB4
More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma (RORC)


(Homo sapiens (Human))
BDBM414297
PNG
(US10435369, Example 184)
Show SMILES OC1(CC(=O)N[C@@H]2CC[C@@]3([C@H]2CCc2cc(ccc32)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c2ccc(F)cc2)CCS(=O)(=O)C1
Show InChI InChI=1S/C28H27F8NO6S2/c29-18-3-5-19(6-4-18)45(42,43)25-10-9-22(37-23(38)14-24(39)11-12-44(40,41)15-24)21(25)7-1-16-13-17(2-8-20(16)25)26(30,27(31,32)33)28(34,35)36/h2-6,8,13,21-22,39H,1,7,9-12,14-15H2,(H,37,38)/t21-,22+,24?,25+/m0/s1
PDB

Reactome pathway

UniProtKB/SwissProt
UniProtKB/TrEMBL

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 3n/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
Inverse agonist activity of potential ligands to RORγ was measured by inhibition of luminescence in a Gal4-luciferase reporter assay in Jurkat c...


US Patent US10435369 (2019)


BindingDB Entry DOI: 10.7270/Q21V5HB4
More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma (RORC)


(Homo sapiens (Human))
BDBM414350
PNG
(US10435369, Example 237)
Show SMILES OC[C@@]1(O)C[C@@H](C1)C(=O)N[C@@H]1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1
Show InChI InChI=1S/C28H27F8NO5S/c29-18-3-5-19(6-4-18)43(41,42)25-10-9-22(37-23(39)16-12-24(40,13-16)14-38)21(25)7-1-15-11-17(2-8-20(15)25)26(30,27(31,32)33)28(34,35)36/h2-6,8,11,16,21-22,38,40H,1,7,9-10,12-14H2,(H,37,39)/t16-,21-,22+,24+,25+/m0/s1
PDB

Reactome pathway

UniProtKB/SwissProt
UniProtKB/TrEMBL

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 3n/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
Inverse agonist activity of potential ligands to RORγ was measured by inhibition of luminescence in a Gal4-luciferase reporter assay in Jurkat c...


US Patent US10435369 (2019)


BindingDB Entry DOI: 10.7270/Q21V5HB4
More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma (RORC)


(Homo sapiens (Human))
BDBM414378
PNG
(US10435369, Example 265 | US10435369, Example 266)
Show SMILES CC(NC(=O)C(C)(C)O)[C@@H]1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1
Show InChI InChI=1S/C28H29F8NO4S/c1-15(37-23(38)24(2,3)39)20-12-13-25(42(40,41)19-8-6-18(29)7-9-19)21-11-5-17(14-16(21)4-10-22(20)25)26(30,27(31,32)33)28(34,35)36/h5-9,11,14-15,20,22,39H,4,10,12-13H2,1-3H3,(H,37,38)/t15?,20-,22-,25+/m0/s1
PDB

Reactome pathway

UniProtKB/SwissProt
UniProtKB/TrEMBL

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 3n/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
Inverse agonist activity of potential ligands to RORγ was measured by inhibition of luminescence in a Gal4-luciferase reporter assay in Jurkat c...


US Patent US10435369 (2019)


BindingDB Entry DOI: 10.7270/Q21V5HB4
More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma (RORC)


(Homo sapiens (Human))
BDBM414167
PNG
(US10435369, Example 54)
Show SMILES C[C@@H](O)CNC(=O)[C@@H]1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1
Show InChI InChI=1S/C26H25F8NO4S/c1-14(36)13-35-22(37)19-10-11-23(40(38,39)18-6-4-17(27)5-7-18)20-9-3-16(12-15(20)2-8-21(19)23)24(28,25(29,30)31)26(32,33)34/h3-7,9,12,14,19,21,36H,2,8,10-11,13H2,1H3,(H,35,37)/t14-,19-,21+,23-/m1/s1
PDB

Reactome pathway

UniProtKB/SwissProt
UniProtKB/TrEMBL

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 3n/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
Inverse agonist activity of potential ligands to RORγ was measured by inhibition of luminescence in a Gal4-luciferase reporter assay in Jurkat c...


US Patent US10435369 (2019)


BindingDB Entry DOI: 10.7270/Q21V5HB4
More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma (RORC)


(Homo sapiens (Human))
BDBM414318
PNG
(US10435369, Example 205 | US10435369, Example 232)
Show SMILES OCCNC(=O)N[C@@H]1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1
Show InChI InChI=1S/C25H24F8N2O4S/c26-16-3-5-17(6-4-16)40(38,39)22-10-9-20(35-21(37)34-11-12-36)19(22)7-1-14-13-15(2-8-18(14)22)23(27,24(28,29)30)25(31,32)33/h2-6,8,13,19-20,36H,1,7,9-12H2,(H2,34,35,37)/t19-,20+,22+/m0/s1
PDB

Reactome pathway

UniProtKB/SwissProt
UniProtKB/TrEMBL

antibodypedia
GoogleScholar
KEGG
PC cid
PC sid
UniChem
US Patent
n/an/a 3n/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
Inverse agonist activity of potential ligands to RORγ was measured by inhibition of luminescence in a Gal4-luciferase reporter assay in Jurkat c...


US Patent US10435369 (2019)


BindingDB Entry DOI: 10.7270/Q21V5HB4
More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma (RORC)


(Homo sapiens (Human))
BDBM414184
PNG
(US10435369, Example 71)
Show SMILES OC1(CNC(=O)[C@@H]2CC[C@@]3([C@H]2CCc2cc(ccc32)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c2ccc(F)cc2)CCCC1
Show InChI InChI=1S/C29H29F8NO4S/c30-19-5-7-20(8-6-19)43(41,42)26-14-11-21(24(39)38-16-25(40)12-1-2-13-25)23(26)9-3-17-15-18(4-10-22(17)26)27(31,28(32,33)34)29(35,36)37/h4-8,10,15,21,23,40H,1-3,9,11-14,16H2,(H,38,39)/t21-,23+,26-/m1/s1
PDB

Reactome pathway

UniProtKB/SwissProt
UniProtKB/TrEMBL

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 4n/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
Inverse agonist activity of potential ligands to RORγ was measured by inhibition of luminescence in a Gal4-luciferase reporter assay in Jurkat c...


US Patent US10435369 (2019)


BindingDB Entry DOI: 10.7270/Q21V5HB4
More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma (RORC)


(Homo sapiens (Human))
BDBM414164
PNG
(US10435369, Example 51)
Show SMILES Fc1ccc(cc1)S(=O)(=O)[C@@]12CC[C@H]([C@@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)NCC1CCC1
Show InChI InChI=1S/C28H27F8NO3S/c29-19-6-8-20(9-7-19)41(39,40)25-13-12-21(24(38)37-15-16-2-1-3-16)23(25)10-4-17-14-18(5-11-22(17)25)26(30,27(31,32)33)28(34,35)36/h5-9,11,14,16,21,23H,1-4,10,12-13,15H2,(H,37,38)/t21-,23+,25-/m1/s1
PDB

Reactome pathway

UniProtKB/SwissProt
UniProtKB/TrEMBL

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 4n/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
Inverse agonist activity of potential ligands to RORγ was measured by inhibition of luminescence in a Gal4-luciferase reporter assay in Jurkat c...


US Patent US10435369 (2019)


BindingDB Entry DOI: 10.7270/Q21V5HB4
More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma (RORC)


(Homo sapiens (Human))
BDBM414319
PNG
(US10435369, Example 206)
Show SMILES CNC(=O)N[C@@H]1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1
Show InChI InChI=1S/C24H22F8N2O3S/c1-33-20(35)34-19-10-11-21(38(36,37)16-6-4-15(25)5-7-16)17-9-3-14(12-13(17)2-8-18(19)21)22(26,23(27,28)29)24(30,31)32/h3-7,9,12,18-19H,2,8,10-11H2,1H3,(H2,33,34,35)/t18-,19+,21+/m0/s1
PDB

Reactome pathway

UniProtKB/SwissProt
UniProtKB/TrEMBL

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 4n/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
Inverse agonist activity of potential ligands to RORγ was measured by inhibition of luminescence in a Gal4-luciferase reporter assay in Jurkat c...


US Patent US10435369 (2019)


BindingDB Entry DOI: 10.7270/Q21V5HB4
More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma (RORC)


(Homo sapiens (Human))
BDBM414369
PNG
(US10435369, Example 256)
Show SMILES OCC(=O)N1CCC(O)(CC1)C(=O)N[C@@H]1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1
Show InChI InChI=1S/C30H30F8N2O6S/c31-19-3-5-20(6-4-19)47(45,46)27-10-9-23(39-25(43)26(44)11-13-40(14-12-26)24(42)16-41)22(27)7-1-17-15-18(2-8-21(17)27)28(32,29(33,34)35)30(36,37)38/h2-6,8,15,22-23,41,44H,1,7,9-14,16H2,(H,39,43)/t22-,23+,27+/m0/s1
PDB

Reactome pathway

UniProtKB/SwissProt
UniProtKB/TrEMBL

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 4n/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
Inverse agonist activity of potential ligands to RORγ was measured by inhibition of luminescence in a Gal4-luciferase reporter assay in Jurkat c...


US Patent US10435369 (2019)


BindingDB Entry DOI: 10.7270/Q21V5HB4
More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma (RORC)


(Homo sapiens (Human))
BDBM414190
PNG
(US10435369, Example 77)
Show SMILES CS(=O)(=O)N1CCC(CC1)NC(=O)[C@@H]1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1
Show InChI InChI=1S/C29H30F8N2O5S2/c1-45(41,42)39-14-11-20(12-15-39)38-25(40)22-10-13-26(46(43,44)21-6-4-19(30)5-7-21)23-9-3-18(16-17(23)2-8-24(22)26)27(31,28(32,33)34)29(35,36)37/h3-7,9,16,20,22,24H,2,8,10-15H2,1H3,(H,38,40)/t22-,24+,26-/m1/s1
PDB

Reactome pathway

UniProtKB/SwissProt
UniProtKB/TrEMBL

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 4n/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
Inverse agonist activity of potential ligands to RORγ was measured by inhibition of luminescence in a Gal4-luciferase reporter assay in Jurkat c...


US Patent US10435369 (2019)


BindingDB Entry DOI: 10.7270/Q21V5HB4
More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma (RORC)


(Homo sapiens (Human))
BDBM414409
PNG
((S)—N-((3R,3aS,9bS)-9b-((4-fluorophenyl)sulfo...)
Show SMILES OCCCN1C[C@H](CC1=O)C(=O)N[C@@H]1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1
Show InChI InChI=1S/C30H30F8N2O5S/c31-20-4-6-21(7-5-20)46(44,45)27-11-10-24(39-26(43)18-15-25(42)40(16-18)12-1-13-41)23(27)8-2-17-14-19(3-9-22(17)27)28(32,29(33,34)35)30(36,37)38/h3-7,9,14,18,23-24,41H,1-2,8,10-13,15-16H2,(H,39,43)/t18-,23-,24+,27+/m0/s1
PDB

Reactome pathway

UniProtKB/SwissProt
UniProtKB/TrEMBL

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 4n/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
Inverse agonist activity of potential ligands to RORγ was measured by inhibition of luminescence in a Gal4-luciferase reporter assay in Jurkat c...


US Patent US10435369 (2019)


BindingDB Entry DOI: 10.7270/Q21V5HB4
More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma (RORC)


(Homo sapiens (Human))
BDBM414267
PNG
(US10435369, Example 154)
Show SMILES CC1(CCC(=O)N1)C(=O)N[C@@H]1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1
Show InChI InChI=1S/C28H26F8N2O4S/c1-24(12-11-22(39)38-24)23(40)37-21-10-13-25(43(41,42)18-6-4-17(29)5-7-18)19-9-3-16(14-15(19)2-8-20(21)25)26(30,27(31,32)33)28(34,35)36/h3-7,9,14,20-21H,2,8,10-13H2,1H3,(H,37,40)(H,38,39)/t20-,21+,24?,25+/m0/s1
PDB

Reactome pathway

UniProtKB/SwissProt
UniProtKB/TrEMBL

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 4n/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
Inverse agonist activity of potential ligands to RORγ was measured by inhibition of luminescence in a Gal4-luciferase reporter assay in Jurkat c...


US Patent US10435369 (2019)


BindingDB Entry DOI: 10.7270/Q21V5HB4
More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma (RORC)


(Homo sapiens (Human))
BDBM414269
PNG
(US10435369, Example 156)
Show SMILES OC(C1CCOCC1)C(=O)N[C@@H]1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1
Show InChI InChI=1S/C29H29F8NO5S/c30-19-3-5-20(6-4-19)44(41,42)26-12-9-23(38-25(40)24(39)16-10-13-43-14-11-16)22(26)7-1-17-15-18(2-8-21(17)26)27(31,28(32,33)34)29(35,36)37/h2-6,8,15-16,22-24,39H,1,7,9-14H2,(H,38,40)/t22-,23+,24?,26+/m0/s1
PDB

Reactome pathway

UniProtKB/SwissProt
UniProtKB/TrEMBL

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 4n/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
Inverse agonist activity of potential ligands to RORγ was measured by inhibition of luminescence in a Gal4-luciferase reporter assay in Jurkat c...


US Patent US10435369 (2019)


BindingDB Entry DOI: 10.7270/Q21V5HB4
More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma (RORC)


(Homo sapiens (Human))
BDBM414185
PNG
(US10435369, Example 72)
Show SMILES OC1(CNC(=O)[C@@H]2CC[C@@]3([C@H]2CCc2cc(ccc32)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c2ccc(F)cc2)CCC1
Show InChI InChI=1S/C28H27F8NO4S/c29-18-4-6-19(7-5-18)42(40,41)25-13-10-20(23(38)37-15-24(39)11-1-12-24)22(25)8-2-16-14-17(3-9-21(16)25)26(30,27(31,32)33)28(34,35)36/h3-7,9,14,20,22,39H,1-2,8,10-13,15H2,(H,37,38)/t20-,22+,25-/m1/s1
PDB

Reactome pathway

UniProtKB/SwissProt
UniProtKB/TrEMBL

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 4n/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
Inverse agonist activity of potential ligands to RORγ was measured by inhibition of luminescence in a Gal4-luciferase reporter assay in Jurkat c...


US Patent US10435369 (2019)


BindingDB Entry DOI: 10.7270/Q21V5HB4
More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma (RORC)


(Homo sapiens (Human))
BDBM414349
PNG
(US10435369, Example 236)
Show SMILES O[C@H]1C[C@@H](C[C@H]1O)C(=O)N[C@@H]1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1
Show InChI InChI=1S/C28H27F8NO5S/c29-17-3-5-18(6-4-17)43(41,42)25-10-9-21(37-24(40)15-12-22(38)23(39)13-15)20(25)7-1-14-11-16(2-8-19(14)25)26(30,27(31,32)33)28(34,35)36/h2-6,8,11,15,20-23,38-39H,1,7,9-10,12-13H2,(H,37,40)/t15-,20-,21+,22-,23+,25+/m0/s1
PDB

Reactome pathway

UniProtKB/SwissProt
UniProtKB/TrEMBL

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 4n/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
Inverse agonist activity of potential ligands to RORγ was measured by inhibition of luminescence in a Gal4-luciferase reporter assay in Jurkat c...


US Patent US10435369 (2019)


BindingDB Entry DOI: 10.7270/Q21V5HB4
More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma (RORC)


(Homo sapiens (Human))
BDBM414166
PNG
(US10435369, Example 53)
Show SMILES O[C@H](CNC(=O)[C@@H]1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1)C(F)(F)F
Show InChI InChI=1S/C26H22F11NO4S/c27-15-3-5-16(6-4-15)43(41,42)22-10-9-17(21(40)38-12-20(39)24(29,30)31)19(22)7-1-13-11-14(2-8-18(13)22)23(28,25(32,33)34)26(35,36)37/h2-6,8,11,17,19-20,39H,1,7,9-10,12H2,(H,38,40)/t17-,19+,20-,22-/m1/s1
PDB

Reactome pathway

UniProtKB/SwissProt
UniProtKB/TrEMBL

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 4n/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
Inverse agonist activity of potential ligands to RORγ was measured by inhibition of luminescence in a Gal4-luciferase reporter assay in Jurkat c...


US Patent US10435369 (2019)


BindingDB Entry DOI: 10.7270/Q21V5HB4
More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma (RORC)


(Homo sapiens (Human))
BDBM414265
PNG
(US10435369, Example 152)
Show SMILES OC1(CC1)C(=O)N[C@@H]1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1
Show InChI InChI=1S/C26H23F8NO4S/c27-16-3-5-17(6-4-16)40(38,39)23-10-9-20(35-21(36)22(37)11-12-22)19(23)7-1-14-13-15(2-8-18(14)23)24(28,25(29,30)31)26(32,33)34/h2-6,8,13,19-20,37H,1,7,9-12H2,(H,35,36)/t19-,20+,23+/m0/s1
PDB

Reactome pathway

UniProtKB/SwissProt
UniProtKB/TrEMBL

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 4n/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
Inverse agonist activity of potential ligands to RORγ was measured by inhibition of luminescence in a Gal4-luciferase reporter assay in Jurkat c...


US Patent US10435369 (2019)


BindingDB Entry DOI: 10.7270/Q21V5HB4
More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma (RORC)


(Homo sapiens (Human))
BDBM414288
PNG
(US10435369, Example 175)
Show SMILES C[C@]1(O)C[C@@H](C1)C(=O)N[C@@H]1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1
Show InChI InChI=1S/C28H27F8NO4S/c1-24(39)13-16(14-24)23(38)37-22-10-11-25(42(40,41)19-6-4-18(29)5-7-19)20-9-3-17(12-15(20)2-8-21(22)25)26(30,27(31,32)33)28(34,35)36/h3-7,9,12,16,21-22,39H,2,8,10-11,13-14H2,1H3,(H,37,38)/t16-,21-,22+,24-,25+/m0/s1
PDB

Reactome pathway

UniProtKB/SwissProt
UniProtKB/TrEMBL

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 4n/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
Inverse agonist activity of potential ligands to RORγ was measured by inhibition of luminescence in a Gal4-luciferase reporter assay in Jurkat c...


US Patent US10435369 (2019)


BindingDB Entry DOI: 10.7270/Q21V5HB4
More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma (RORC)


(Homo sapiens (Human))
BDBM414383
PNG
(US10435369, Example 270)
Show SMILES C[C@H](O)C(=O)NC(C)[C@@H]1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1
Show InChI InChI=1S/C27H27F8NO4S/c1-14(36-23(38)15(2)37)20-11-12-24(41(39,40)19-7-5-18(28)6-8-19)21-10-4-17(13-16(21)3-9-22(20)24)25(29,26(30,31)32)27(33,34)35/h4-8,10,13-15,20,22,37H,3,9,11-12H2,1-2H3,(H,36,38)/t14?,15-,20-,22-,24+/m0/s1
PDB

Reactome pathway

UniProtKB/SwissProt
UniProtKB/TrEMBL

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 4n/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
Inverse agonist activity of potential ligands to RORγ was measured by inhibition of luminescence in a Gal4-luciferase reporter assay in Jurkat c...


US Patent US10435369 (2019)


BindingDB Entry DOI: 10.7270/Q21V5HB4
More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma (RORC)


(Homo sapiens (Human))
BDBM414407
PNG
((S)-1-(2-cyanoethyl)-N-((3R,3aS,9bS)-9b-((4-fluoro...)
Show SMILES Fc1ccc(cc1)S(=O)(=O)[C@@]12CC[C@@H](NC(=O)[C@@H]3CN(CCC#N)C(=O)C3)[C@@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F
Show InChI InChI=1S/C30H27F8N3O4S/c31-20-4-6-21(7-5-20)46(44,45)27-11-10-24(40-26(43)18-15-25(42)41(16-18)13-1-12-39)23(27)8-2-17-14-19(3-9-22(17)27)28(32,29(33,34)35)30(36,37)38/h3-7,9,14,18,23-24H,1-2,8,10-11,13,15-16H2,(H,40,43)/t18-,23-,24+,27+/m0/s1
PDB

Reactome pathway

UniProtKB/SwissProt
UniProtKB/TrEMBL

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 4n/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
Inverse agonist activity of potential ligands to RORγ was measured by inhibition of luminescence in a Gal4-luciferase reporter assay in Jurkat c...


US Patent US10435369 (2019)


BindingDB Entry DOI: 10.7270/Q21V5HB4
More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma (RORC)


(Homo sapiens (Human))
BDBM414168
PNG
(US10435369, Example 55)
Show SMILES OC[C@H](O)CNC(=O)[C@@H]1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1
Show InChI InChI=1S/C26H25F8NO5S/c27-16-3-5-18(6-4-16)41(39,40)23-10-9-19(22(38)35-12-17(37)13-36)21(23)7-1-14-11-15(2-8-20(14)23)24(28,25(29,30)31)26(32,33)34/h2-6,8,11,17,19,21,36-37H,1,7,9-10,12-13H2,(H,35,38)/t17-,19-,21+,23-/m1/s1
PDB

Reactome pathway

UniProtKB/SwissProt
UniProtKB/TrEMBL

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 5n/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
Inverse agonist activity of potential ligands to RORγ was measured by inhibition of luminescence in a Gal4-luciferase reporter assay in Jurkat c...


US Patent US10435369 (2019)


BindingDB Entry DOI: 10.7270/Q21V5HB4
More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma (RORC)


(Homo sapiens (Human))
BDBM414197
PNG
(US10435369, Example 84)
Show SMILES Fc1ccc(cc1)S(=O)(=O)[C@@]12CC[C@H]([C@@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)N1CCC2(CC(=O)N2)CC1
Show InChI InChI=1S/C30H28F8N2O4S/c31-19-3-5-20(6-4-19)45(43,44)27-10-9-21(25(42)40-13-11-26(12-14-40)16-24(41)39-26)23(27)7-1-17-15-18(2-8-22(17)27)28(32,29(33,34)35)30(36,37)38/h2-6,8,15,21,23H,1,7,9-14,16H2,(H,39,41)/t21-,23+,27-/m1/s1
PDB

Reactome pathway

UniProtKB/SwissProt
UniProtKB/TrEMBL

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 5n/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
Inverse agonist activity of potential ligands to RORγ was measured by inhibition of luminescence in a Gal4-luciferase reporter assay in Jurkat c...


US Patent US10435369 (2019)


BindingDB Entry DOI: 10.7270/Q21V5HB4
More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma (RORC)


(Homo sapiens (Human))
BDBM414235
PNG
(US10435369, Example 122)
Show SMILES Fc1ccc(cc1)S(=O)(=O)[C@@]12CC[C@@H](NC(=O)Cc3ccncc3)[C@@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F
Show InChI InChI=1S/C29H24F8N2O3S/c30-20-3-5-21(6-4-20)43(41,42)26-12-9-24(39-25(40)15-17-10-13-38-14-11-17)23(26)7-1-18-16-19(2-8-22(18)26)27(31,28(32,33)34)29(35,36)37/h2-6,8,10-11,13-14,16,23-24H,1,7,9,12,15H2,(H,39,40)/t23-,24+,26+/m0/s1
PDB

Reactome pathway

UniProtKB/SwissProt
UniProtKB/TrEMBL

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 5n/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
Inverse agonist activity of potential ligands to RORγ was measured by inhibition of luminescence in a Gal4-luciferase reporter assay in Jurkat c...


US Patent US10435369 (2019)


BindingDB Entry DOI: 10.7270/Q21V5HB4
More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma (RORC)


(Homo sapiens (Human))
BDBM414342
PNG
(N-((3R,3aS,9bS)-9b-((4-fluorophenyl)sulfonyl)-7-(p...)
Show SMILES CC(C)(O)CN1N(CCC1=O)C(=O)N[C@@H]1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1
Show InChI InChI=1S/C30H31F8N3O5S/c1-26(2,44)16-41-24(42)12-14-40(41)25(43)39-23-11-13-27(47(45,46)20-7-5-19(31)6-8-20)21-10-4-18(15-17(21)3-9-22(23)27)28(32,29(33,34)35)30(36,37)38/h4-8,10,15,22-23,44H,3,9,11-14,16H2,1-2H3,(H,39,43)/t22-,23+,27+/m0/s1
PDB

Reactome pathway

UniProtKB/SwissProt
UniProtKB/TrEMBL

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 5n/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
Inverse agonist activity of potential ligands to RORγ was measured by inhibition of luminescence in a Gal4-luciferase reporter assay in Jurkat c...


US Patent US10435369 (2019)


BindingDB Entry DOI: 10.7270/Q21V5HB4
More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma (RORC)


(Homo sapiens (Human))
BDBM414287
PNG
(US10435369, Example 174)
Show SMILES C[C@@]1(O)C[C@@H](C1)C(=O)N[C@@H]1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1
Show InChI InChI=1S/C28H27F8NO4S/c1-24(39)13-16(14-24)23(38)37-22-10-11-25(42(40,41)19-6-4-18(29)5-7-19)20-9-3-17(12-15(20)2-8-21(22)25)26(30,27(31,32)33)28(34,35)36/h3-7,9,12,16,21-22,39H,2,8,10-11,13-14H2,1H3,(H,37,38)/t16-,21-,22+,24+,25+/m0/s1
PDB

Reactome pathway

UniProtKB/SwissProt
UniProtKB/TrEMBL

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 5n/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
Inverse agonist activity of potential ligands to RORγ was measured by inhibition of luminescence in a Gal4-luciferase reporter assay in Jurkat c...


US Patent US10435369 (2019)


BindingDB Entry DOI: 10.7270/Q21V5HB4
More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma (RORC)


(Homo sapiens (Human))
BDBM414298
PNG
(US10435369, Example 185)
Show SMILES CC(=O)NCC(=O)N[C@@H]1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1
Show InChI InChI=1S/C26H24F8N2O4S/c1-14(37)35-13-22(38)36-21-10-11-23(41(39,40)18-6-4-17(27)5-7-18)19-9-3-16(12-15(19)2-8-20(21)23)24(28,25(29,30)31)26(32,33)34/h3-7,9,12,20-21H,2,8,10-11,13H2,1H3,(H,35,37)(H,36,38)/t20-,21+,23+/m0/s1
PDB

Reactome pathway

UniProtKB/SwissProt
UniProtKB/TrEMBL

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 5n/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
Inverse agonist activity of potential ligands to RORγ was measured by inhibition of luminescence in a Gal4-luciferase reporter assay in Jurkat c...


US Patent US10435369 (2019)


BindingDB Entry DOI: 10.7270/Q21V5HB4
More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma (RORC)


(Homo sapiens (Human))
BDBM414411
PNG
(4-fluoro-N-((3R,3aS,9bS)-9b-((4-fluorophenyl)sulfo...)
Show SMILES Fc1ccc(cc1)S(=O)(=O)[C@@]12CC[C@@H](NC(=O)C3(F)CCS(=O)(=O)CC3)[C@@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F
Show InChI InChI=1S/C28H26F9NO5S2/c29-18-3-5-19(6-4-18)45(42,43)25-10-9-22(38-23(39)24(30)11-13-44(40,41)14-12-24)21(25)7-1-16-15-17(2-8-20(16)25)26(31,27(32,33)34)28(35,36)37/h2-6,8,15,21-22H,1,7,9-14H2,(H,38,39)/t21-,22+,25+/m0/s1
PDB

Reactome pathway

UniProtKB/SwissProt
UniProtKB/TrEMBL

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 5n/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
Inverse agonist activity of potential ligands to RORγ was measured by inhibition of luminescence in a Gal4-luciferase reporter assay in Jurkat c...


US Patent US10435369 (2019)


BindingDB Entry DOI: 10.7270/Q21V5HB4
More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma (RORC)


(Homo sapiens (Human))
BDBM414143
PNG
(US10435369, Example 30)
Show SMILES CC(C)(O)CNC(=O)[C@@H]1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1
Show InChI InChI=1S/C27H27F8NO4S/c1-23(2,38)14-36-22(37)19-11-12-24(41(39,40)18-7-5-17(28)6-8-18)20-10-4-16(13-15(20)3-9-21(19)24)25(29,26(30,31)32)27(33,34)35/h4-8,10,13,19,21,38H,3,9,11-12,14H2,1-2H3,(H,36,37)/t19-,21+,24-/m1/s1
PDB

Reactome pathway

UniProtKB/SwissProt
UniProtKB/TrEMBL

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 5n/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
Inverse agonist activity of potential ligands to RORγ was measured by inhibition of luminescence in a Gal4-luciferase reporter assay in Jurkat c...


US Patent US10435369 (2019)


BindingDB Entry DOI: 10.7270/Q21V5HB4
More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma (RORC)


(Homo sapiens (Human))
BDBM414232
PNG
(N-((3R,3aS,9bS)-9b-((4-fluorophenyl)sulfonyl)-7-(p...)
Show SMILES CC(=O)N[C@@H]1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1
Show InChI InChI=1S/C24H21F8NO3S/c1-13(34)33-20-10-11-21(37(35,36)17-6-4-16(25)5-7-17)18-9-3-15(12-14(18)2-8-19(20)21)22(26,23(27,28)29)24(30,31)32/h3-7,9,12,19-20H,2,8,10-11H2,1H3,(H,33,34)/t19-,20+,21+/m0/s1
PDB

Reactome pathway

UniProtKB/SwissProt
UniProtKB/TrEMBL

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 5n/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
Inverse agonist activity of potential ligands to RORγ was measured by inhibition of luminescence in a Gal4-luciferase reporter assay in Jurkat c...


US Patent US10435369 (2019)


BindingDB Entry DOI: 10.7270/Q21V5HB4
More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma (RORC)


(Homo sapiens (Human))
BDBM414245
PNG
(US10435369, Example 132)
Show SMILES CN1[C@@H](C[C@@H](F)C1=O)C(=O)N[C@@H]1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1
Show InChI InChI=1S/C28H25F9N2O4S/c1-39-22(13-20(30)24(39)41)23(40)38-21-10-11-25(44(42,43)17-6-4-16(29)5-7-17)18-9-3-15(12-14(18)2-8-19(21)25)26(31,27(32,33)34)28(35,36)37/h3-7,9,12,19-22H,2,8,10-11,13H2,1H3,(H,38,40)/t19-,20+,21+,22-,25+/m0/s1
PDB

Reactome pathway

UniProtKB/SwissProt
UniProtKB/TrEMBL

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 5n/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
Inverse agonist activity of potential ligands to RORγ was measured by inhibition of luminescence in a Gal4-luciferase reporter assay in Jurkat c...


US Patent US10435369 (2019)


BindingDB Entry DOI: 10.7270/Q21V5HB4
More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma (RORC)


(Homo sapiens (Human))
BDBM414183
PNG
(US10435369, Example 70)
Show SMILES OC1(CNC(=O)[C@@H]2CC[C@@]3([C@H]2CCc2cc(ccc32)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c2ccc(F)cc2)CCCCC1
Show InChI InChI=1S/C30H31F8NO4S/c31-20-6-8-21(9-7-20)44(42,43)27-15-12-22(25(40)39-17-26(41)13-2-1-3-14-26)24(27)10-4-18-16-19(5-11-23(18)27)28(32,29(33,34)35)30(36,37)38/h5-9,11,16,22,24,41H,1-4,10,12-15,17H2,(H,39,40)/t22-,24+,27-/m1/s1
PDB

Reactome pathway

UniProtKB/SwissProt
UniProtKB/TrEMBL

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 6n/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
Inverse agonist activity of potential ligands to RORγ was measured by inhibition of luminescence in a Gal4-luciferase reporter assay in Jurkat c...


US Patent US10435369 (2019)


BindingDB Entry DOI: 10.7270/Q21V5HB4
More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma (RORC)


(Homo sapiens (Human))
BDBM414248
PNG
(US10435369, Example 135 | US10435369, Example 136 ...)
Show SMILES CC1CC(CCS1(=O)=O)C(=O)N[C@@H]1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1
Show InChI InChI=1S/C29H29F8NO5S2/c1-16-14-18(11-13-44(16,40)41)25(39)38-24-10-12-26(45(42,43)21-6-4-20(30)5-7-21)22-9-3-19(15-17(22)2-8-23(24)26)27(31,28(32,33)34)29(35,36)37/h3-7,9,15-16,18,23-24H,2,8,10-14H2,1H3,(H,38,39)/t16?,18?,23-,24+,26+/m0/s1
PDB

Reactome pathway

UniProtKB/SwissProt
UniProtKB/TrEMBL

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 6n/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
Inverse agonist activity of potential ligands to RORγ was measured by inhibition of luminescence in a Gal4-luciferase reporter assay in Jurkat c...


US Patent US10435369 (2019)


BindingDB Entry DOI: 10.7270/Q21V5HB4
More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma (RORC)


(Homo sapiens (Human))
BDBM414351
PNG
(US10435369, Example 238)
Show SMILES OC[C@]1(O)C[C@@H](C1)C(=O)N[C@@H]1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1
Show InChI InChI=1S/C28H27F8NO5S/c29-18-3-5-19(6-4-18)43(41,42)25-10-9-22(37-23(39)16-12-24(40,13-16)14-38)21(25)7-1-15-11-17(2-8-20(15)25)26(30,27(31,32)33)28(34,35)36/h2-6,8,11,16,21-22,38,40H,1,7,9-10,12-14H2,(H,37,39)/t16-,21-,22+,24-,25+/m0/s1
PDB

Reactome pathway

UniProtKB/SwissProt
UniProtKB/TrEMBL

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 6n/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
Inverse agonist activity of potential ligands to RORγ was measured by inhibition of luminescence in a Gal4-luciferase reporter assay in Jurkat c...


US Patent US10435369 (2019)


BindingDB Entry DOI: 10.7270/Q21V5HB4
More data for this
Ligand-Target Pair
Displayed 1 to 50 (of 304 total )  |  Next  |  Last  >>
* indicates data uncertainty>20%