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Patent code US10435400

Compile Data Set for Download or QSAR
Found 122 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Epidermal growth factor receptor(L858R, T790M)


(Homo sapiens (Human))
BDBM414541
PNG
(US10435400, Compound Z-54)
Show SMILES COc1cc(N(C)CCN(C)C)c(NC(=O)C=C)cc1Nc1nccc(n1)-c1cnc2n(C)cc(Cl)c2c1
Show InChI InChI=1S/C27H31ClN8O2/c1-7-25(37)31-21-13-22(24(38-6)14-23(21)35(4)11-10-34(2)3)33-27-29-9-8-20(32-27)17-12-18-19(28)16-36(5)26(18)30-15-17/h7-9,12-16H,1,10-11H2,2-6H3,(H,31,37)(H,29,32,33)
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SHANGHAI HAIYAN PHARMACEUTICAL TECHNOLOGY CO. LTD.

US Patent


Assay Description
The inhibitory effects of compounds to be tested on double mutant EGFR kinase (EGFR T790M/L858R Kinase) (Invitrogen, PV4879) and wild-type EGFR kinas...


US Patent US10435400 (2019)


BindingDB Entry DOI: 10.7270/Q20V8G4V
More data for this
Ligand-Target Pair
Epidermal growth factor receptor(L858R, T790M)


(Homo sapiens (Human))
BDBM414577
PNG
(US10435400, Compound Z-123)
Show SMILES COc1cc(N(C)CCN(C)C)c(NC(=O)C=C)cc1Nc1ncc(F)c(n1)-c1cnc2n(C)cc(Cl)c2c1
Show InChI InChI=1S/C27H30ClFN8O2/c1-7-24(38)32-20-11-21(23(39-6)12-22(20)36(4)9-8-35(2)3)33-27-31-14-19(29)25(34-27)16-10-17-18(28)15-37(5)26(17)30-13-16/h7,10-15H,1,8-9H2,2-6H3,(H,32,38)(H,31,33,34)
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SHANGHAI HAIYAN PHARMACEUTICAL TECHNOLOGY CO. LTD.

US Patent


Assay Description
The inhibitory effects of compounds to be tested on double mutant EGFR kinase (EGFR T790M/L858R Kinase) (Invitrogen, PV4879) and wild-type EGFR kinas...


US Patent US10435400 (2019)


BindingDB Entry DOI: 10.7270/Q20V8G4V
More data for this
Ligand-Target Pair
Epidermal growth factor receptor(L858R, T790M)


(Homo sapiens (Human))
BDBM414525
PNG
(N-(2-((2-(dimethylamino)ethyl)(methyl)amino)-4-met...)
Show SMILES COc1cc(N(C)CCN(C)C)c(NC(=O)C=C)cc1Nc1nccc(n1)-c1cnc2n(C)ccc2c1
Show InChI InChI=1S/C27H32N8O2/c1-7-25(36)30-21-15-22(24(37-6)16-23(21)34(4)13-12-33(2)3)32-27-28-10-8-20(31-27)19-14-18-9-11-35(5)26(18)29-17-19/h7-11,14-17H,1,12-13H2,2-6H3,(H,30,36)(H,28,31,32)
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SHANGHAI HAIYAN PHARMACEUTICAL TECHNOLOGY CO. LTD.

US Patent


Assay Description
The inhibitory effects of compounds to be tested on double mutant EGFR kinase (EGFR T790M/L858R Kinase) (Invitrogen, PV4879) and wild-type EGFR kinas...


US Patent US10435400 (2019)


BindingDB Entry DOI: 10.7270/Q20V8G4V
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM50322823
PNG
((S)-N-(4-(3-chloro-4-fluorophenylamino)-7-(tetrahy...)
Show SMILES CN(C)C\C=C\C(=O)Nc1cc2c(Nc3ccc(F)c(Cl)c3)ncnc2cc1O[C@H]1CCOC1
Show InChI InChI=1S/C24H25ClFN5O3/c1-31(2)8-3-4-23(32)30-21-11-17-20(12-22(21)34-16-7-9-33-13-16)27-14-28-24(17)29-15-5-6-19(26)18(25)10-15/h3-6,10-12,14,16H,7-9,13H2,1-2H3,(H,30,32)(H,27,28,29)/b4-3+/t16-/m0/s1
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SHANGHAI HAIYAN PHARMACEUTICAL TECHNOLOGY CO. LTD.

US Patent


Assay Description
The inhibitory effects of compounds to be tested on double mutant EGFR kinase (EGFR T790M/L858R Kinase) (Invitrogen, PV4879) and wild-type EGFR kinas...


US Patent US10435400 (2019)


BindingDB Entry DOI: 10.7270/Q20V8G4V
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Epidermal growth factor receptor(L858R, T790M)


(Homo sapiens (Human))
BDBM414553
PNG
(US10435400, Compound Z-94)
Show SMILES COc1cc(N(C)CCN(C)C)c(NC(=O)C=C)cc1Nc1ncc(Cl)c(n1)-c1cn(C)nc1C
Show InChI InChI=1S/C24H31ClN8O2/c1-8-22(34)27-18-11-19(21(35-7)12-20(18)32(5)10-9-31(3)4)28-24-26-13-17(25)23(29-24)16-14-33(6)30-15(16)2/h8,11-14H,1,9-10H2,2-7H3,(H,27,34)(H,26,28,29)
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SHANGHAI HAIYAN PHARMACEUTICAL TECHNOLOGY CO. LTD.

US Patent


Assay Description
The inhibitory effects of compounds to be tested on double mutant EGFR kinase (EGFR T790M/L858R Kinase) (Invitrogen, PV4879) and wild-type EGFR kinas...


US Patent US10435400 (2019)


BindingDB Entry DOI: 10.7270/Q20V8G4V
More data for this
Ligand-Target Pair
Epidermal growth factor receptor(L858R, T790M)


(Homo sapiens (Human))
BDBM414573
PNG
(US10435400, Compound Z-117)
Show SMILES COc1cc(OCCN(C)C)c(NC(=O)C=C)cc1Nc1nccc(n1)-c1cnc2n(C)ccc2c1
Show InChI InChI=1S/C26H29N7O3/c1-6-24(34)29-21-14-20(22(35-5)15-23(21)36-12-11-32(2)3)31-26-27-9-7-19(30-26)18-13-17-8-10-33(4)25(17)28-16-18/h6-10,13-16H,1,11-12H2,2-5H3,(H,29,34)(H,27,30,31)
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SHANGHAI HAIYAN PHARMACEUTICAL TECHNOLOGY CO. LTD.

US Patent


Assay Description
The inhibitory effects of compounds to be tested on double mutant EGFR kinase (EGFR T790M/L858R Kinase) (Invitrogen, PV4879) and wild-type EGFR kinas...


US Patent US10435400 (2019)


BindingDB Entry DOI: 10.7270/Q20V8G4V
More data for this
Ligand-Target Pair
Epidermal growth factor receptor(L858R, T790M)


(Homo sapiens (Human))
BDBM414526
PNG
(US10435400, Compound Z-20)
Show SMILES COc1cc(N(C)CCN(C)N)c(NC(=O)C=C)cc1Nc1ncc(F)c(n1)-c1cnc2n(C)ccc2c1
Show InChI InChI=1S/C26H30FN9O2/c1-6-23(37)31-19-12-20(22(38-5)13-21(19)34(2)9-10-36(4)28)32-26-30-15-18(27)24(33-26)17-11-16-7-8-35(3)25(16)29-14-17/h6-8,11-15H,1,9-10,28H2,2-5H3,(H,31,37)(H,30,32,33)
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SHANGHAI HAIYAN PHARMACEUTICAL TECHNOLOGY CO. LTD.

US Patent


Assay Description
The inhibitory effects of compounds to be tested on double mutant EGFR kinase (EGFR T790M/L858R Kinase) (Invitrogen, PV4879) and wild-type EGFR kinas...


US Patent US10435400 (2019)


BindingDB Entry DOI: 10.7270/Q20V8G4V
More data for this
Ligand-Target Pair
Epidermal growth factor receptor(L858R, T790M)


(Homo sapiens (Human))
BDBM414556
PNG
(US10435400, Compound Z-96)
Show SMILES COc1cc(N2CCC(CC2)N(C)C)c(NC(=O)C=C)cc1Nc1ncc(Cl)c(n1)-c1cnn(c1)C1CCN(CC1)C(=O)OC(C)(C)C
Show InChI InChI=1S/C34H46ClN9O4/c1-8-30(45)38-26-17-27(29(47-7)18-28(26)42-13-9-23(10-14-42)41(5)6)39-32-36-20-25(35)31(40-32)22-19-37-44(21-22)24-11-15-43(16-12-24)33(46)48-34(2,3)4/h8,17-21,23-24H,1,9-16H2,2-7H3,(H,38,45)(H,36,39,40)
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SHANGHAI HAIYAN PHARMACEUTICAL TECHNOLOGY CO. LTD.

US Patent


Assay Description
The inhibitory effects of compounds to be tested on double mutant EGFR kinase (EGFR T790M/L858R Kinase) (Invitrogen, PV4879) and wild-type EGFR kinas...


US Patent US10435400 (2019)


BindingDB Entry DOI: 10.7270/Q20V8G4V
More data for this
Ligand-Target Pair
Epidermal growth factor receptor(L858R, T790M)


(Homo sapiens (Human))
BDBM414544
PNG
(US10435400, Compound comparative)
Show SMILES COc1cc(N2CCC(CC2)N(C)C)c(NC(=O)C=C)cc1Nc1nccc(n1)-c1cccnc1
Show InChI InChI=1S/C26H31N7O2/c1-5-25(34)29-21-15-22(31-26-28-12-8-20(30-26)18-7-6-11-27-17-18)24(35-4)16-23(21)33-13-9-19(10-14-33)32(2)3/h5-8,11-12,15-17,19H,1,9-10,13-14H2,2-4H3,(H,29,34)(H,28,30,31)
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SHANGHAI HAIYAN PHARMACEUTICAL TECHNOLOGY CO. LTD.

US Patent


Assay Description
The inhibitory effects of compounds to be tested on double mutant EGFR kinase (EGFR T790M/L858R Kinase) (Invitrogen, PV4879) and wild-type EGFR kinas...


US Patent US10435400 (2019)


BindingDB Entry DOI: 10.7270/Q20V8G4V
More data for this
Ligand-Target Pair
Epidermal growth factor receptor(L858R, T790M)


(Homo sapiens (Human))
BDBM414544
PNG
(US10435400, Compound comparative)
Show SMILES COc1cc(N2CCC(CC2)N(C)C)c(NC(=O)C=C)cc1Nc1nccc(n1)-c1cccnc1
Show InChI InChI=1S/C26H31N7O2/c1-5-25(34)29-21-15-22(31-26-28-12-8-20(30-26)18-7-6-11-27-17-18)24(35-4)16-23(21)33-13-9-19(10-14-33)32(2)3/h5-8,11-12,15-17,19H,1,9-10,13-14H2,2-4H3,(H,29,34)(H,28,30,31)
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SHANGHAI HAIYAN PHARMACEUTICAL TECHNOLOGY CO. LTD.

US Patent


Assay Description
The inhibitory effects of compounds to be tested on double mutant EGFR kinase (EGFR T790M/L858R Kinase) (Invitrogen, PV4879) and wild-type EGFR kinas...


US Patent US10435400 (2019)


BindingDB Entry DOI: 10.7270/Q20V8G4V
More data for this
Ligand-Target Pair
Epidermal growth factor receptor(L858R, T790M)


(Homo sapiens (Human))
BDBM414549
PNG
(US10435400, Compound Z-55)
Show SMILES COc1cc(N(C)CCN(C)C)c(NC(=O)C=C)cc1Nc1ncc(Cl)c(n1)-c1cnn(C)c1C
Show InChI InChI=1S/C24H31ClN8O2/c1-8-22(34)28-18-11-19(21(35-7)12-20(18)32(5)10-9-31(3)4)29-24-26-14-17(25)23(30-24)16-13-27-33(6)15(16)2/h8,11-14H,1,9-10H2,2-7H3,(H,28,34)(H,26,29,30)
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SHANGHAI HAIYAN PHARMACEUTICAL TECHNOLOGY CO. LTD.

US Patent


Assay Description
The inhibitory effects of compounds to be tested on double mutant EGFR kinase (EGFR T790M/L858R Kinase) (Invitrogen, PV4879) and wild-type EGFR kinas...


US Patent US10435400 (2019)


BindingDB Entry DOI: 10.7270/Q20V8G4V
More data for this
Ligand-Target Pair
Epidermal growth factor receptor(L858R, T790M)


(Homo sapiens (Human))
BDBM414562
PNG
(US10435400, Compound Z-102)
Show SMILES COc1cc(N2CCC(CC2)N(C)C)c(NC(=O)C=C)cc1Nc1ncc(Cl)c(n1)-c1cn[nH]c1
Show InChI InChI=1S/C24H29ClN8O2/c1-5-22(34)29-18-10-19(30-24-26-14-17(25)23(31-24)15-12-27-28-13-15)21(35-4)11-20(18)33-8-6-16(7-9-33)32(2)3/h5,10-14,16H,1,6-9H2,2-4H3,(H,27,28)(H,29,34)(H,26,30,31)
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SHANGHAI HAIYAN PHARMACEUTICAL TECHNOLOGY CO. LTD.

US Patent


Assay Description
The inhibitory effects of compounds to be tested on double mutant EGFR kinase (EGFR T790M/L858R Kinase) (Invitrogen, PV4879) and wild-type EGFR kinas...


US Patent US10435400 (2019)


BindingDB Entry DOI: 10.7270/Q20V8G4V
More data for this
Ligand-Target Pair
Epidermal growth factor receptor(L858R, T790M)


(Homo sapiens (Human))
BDBM414574
PNG
(US10435400, Compound Z-118)
Show SMILES COc1cc(OCCN(C)C)c(NC(=O)C=C)cc1Nc1ncc(F)c(n1)-c1cnc2n(C)ccc2c1
Show InChI InChI=1S/C26H28FN7O3/c1-6-23(35)30-20-12-19(21(36-5)13-22(20)37-10-9-33(2)3)31-26-29-15-18(27)24(32-26)17-11-16-7-8-34(4)25(16)28-14-17/h6-8,11-15H,1,9-10H2,2-5H3,(H,30,35)(H,29,31,32)
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SHANGHAI HAIYAN PHARMACEUTICAL TECHNOLOGY CO. LTD.

US Patent


Assay Description
The inhibitory effects of compounds to be tested on double mutant EGFR kinase (EGFR T790M/L858R Kinase) (Invitrogen, PV4879) and wild-type EGFR kinas...


US Patent US10435400 (2019)


BindingDB Entry DOI: 10.7270/Q20V8G4V
More data for this
Ligand-Target Pair
Epidermal growth factor receptor(L858R, T790M)


(Homo sapiens (Human))
BDBM414579
PNG
(US10435400, Compound Z-125)
Show SMILES COc1cc(N(C)CCN(C)C)c(NC(=O)C=C)cc1Nc1ncc(Cl)c(n1)-c1cnc2n(ccc2c1)C(C)C
Show InChI InChI=1S/C29H35ClN8O2/c1-8-26(39)33-22-14-23(25(40-7)15-24(22)37(6)12-11-36(4)5)34-29-32-17-21(30)27(35-29)20-13-19-9-10-38(18(2)3)28(19)31-16-20/h8-10,13-18H,1,11-12H2,2-7H3,(H,33,39)(H,32,34,35)
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SHANGHAI HAIYAN PHARMACEUTICAL TECHNOLOGY CO. LTD.

US Patent


Assay Description
The inhibitory effects of compounds to be tested on double mutant EGFR kinase (EGFR T790M/L858R Kinase) (Invitrogen, PV4879) and wild-type EGFR kinas...


US Patent US10435400 (2019)


BindingDB Entry DOI: 10.7270/Q20V8G4V
More data for this
Ligand-Target Pair
Epidermal growth factor receptor(L858R, T790M)


(Homo sapiens (Human))
BDBM414564
PNG
(US10435400, Compound Z-106)
Show SMILES CNCCN(C)c1cc(OC)c(Nc2nccc(n2)-c2cnc3n(C)ccc3c2)cc1NC(=O)C=C
Show InChI InChI=1S/C26H30N8O2/c1-6-24(35)30-20-14-21(23(36-5)15-22(20)33(3)12-10-27-2)32-26-28-9-7-19(31-26)18-13-17-8-11-34(4)25(17)29-16-18/h6-9,11,13-16,27H,1,10,12H2,2-5H3,(H,30,35)(H,28,31,32)
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SHANGHAI HAIYAN PHARMACEUTICAL TECHNOLOGY CO. LTD.

US Patent


Assay Description
The inhibitory effects of compounds to be tested on double mutant EGFR kinase (EGFR T790M/L858R Kinase) (Invitrogen, PV4879) and wild-type EGFR kinas...


US Patent US10435400 (2019)


BindingDB Entry DOI: 10.7270/Q20V8G4V
More data for this
Ligand-Target Pair
Epidermal growth factor receptor(L858R, T790M)


(Homo sapiens (Human))
BDBM414580
PNG
(US10435400, Compound Z-126)
Show SMILES COc1cc(N(C)CCN(C)C)c(NC(=O)C=C)cc1Nc1ncc(Cl)c(n1)-c1cnc2n(ccc2c1)C1CC1
Show InChI InChI=1S/C29H33ClN8O2/c1-6-26(39)33-22-14-23(25(40-5)15-24(22)37(4)12-11-36(2)3)34-29-32-17-21(30)27(35-29)19-13-18-9-10-38(20-7-8-20)28(18)31-16-19/h6,9-10,13-17,20H,1,7-8,11-12H2,2-5H3,(H,33,39)(H,32,34,35)
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SHANGHAI HAIYAN PHARMACEUTICAL TECHNOLOGY CO. LTD.

US Patent


Assay Description
The inhibitory effects of compounds to be tested on double mutant EGFR kinase (EGFR T790M/L858R Kinase) (Invitrogen, PV4879) and wild-type EGFR kinas...


US Patent US10435400 (2019)


BindingDB Entry DOI: 10.7270/Q20V8G4V
More data for this
Ligand-Target Pair
Epidermal growth factor receptor(L858R, T790M)


(Homo sapiens (Human))
BDBM414534
PNG
(US10435400, Compound Z-32)
Show SMILES COc1cc(N(C)CCN(C)C)c(NC(=O)C=C)cc1Nc1ncc(C(C)=O)c(n1)-c1cnc2n(C)ccc2c1
Show InChI InChI=1S/C29H34N8O3/c1-8-26(39)32-22-14-23(25(40-7)15-24(22)36(5)12-11-35(3)4)33-29-31-17-21(18(2)38)27(34-29)20-13-19-9-10-37(6)28(19)30-16-20/h8-10,13-17H,1,11-12H2,2-7H3,(H,32,39)(H,31,33,34)
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SHANGHAI HAIYAN PHARMACEUTICAL TECHNOLOGY CO. LTD.

US Patent


Assay Description
The inhibitory effects of compounds to be tested on double mutant EGFR kinase (EGFR T790M/L858R Kinase) (Invitrogen, PV4879) and wild-type EGFR kinas...


US Patent US10435400 (2019)


BindingDB Entry DOI: 10.7270/Q20V8G4V
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM414541
PNG
(US10435400, Compound Z-54)
Show SMILES COc1cc(N(C)CCN(C)C)c(NC(=O)C=C)cc1Nc1nccc(n1)-c1cnc2n(C)cc(Cl)c2c1
Show InChI InChI=1S/C27H31ClN8O2/c1-7-25(37)31-21-13-22(24(38-6)14-23(21)35(4)11-10-34(2)3)33-27-29-9-8-20(32-27)17-12-18-19(28)16-36(5)26(18)30-15-17/h7-9,12-16H,1,10-11H2,2-6H3,(H,31,37)(H,29,32,33)
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SHANGHAI HAIYAN PHARMACEUTICAL TECHNOLOGY CO. LTD.

US Patent


Assay Description
The inhibitory effects of compounds to be tested on double mutant EGFR kinase (EGFR T790M/L858R Kinase) (Invitrogen, PV4879) and wild-type EGFR kinas...


US Patent US10435400 (2019)


BindingDB Entry DOI: 10.7270/Q20V8G4V
More data for this
Ligand-Target Pair
Epidermal growth factor receptor(L858R, T790M)


(Homo sapiens (Human))
BDBM414520
PNG
(N-(5-(5-chloro-4-(1-methyl-1H-pyrrolo[2,3-b]pyridi...)
Show SMILES COc1cc(N(C)CCN(C)C)c(NC(=O)C=C)cc1Nc1ncc(Cl)c(n1)-c1cnc2n(C)ccc2c1
Show InChI InChI=1S/C27H31ClN8O2/c1-7-24(37)31-20-13-21(23(38-6)14-22(20)35(4)11-10-34(2)3)32-27-30-16-19(28)25(33-27)18-12-17-8-9-36(5)26(17)29-15-18/h7-9,12-16H,1,10-11H2,2-6H3,(H,31,37)(H,30,32,33)
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SHANGHAI HAIYAN PHARMACEUTICAL TECHNOLOGY CO. LTD.

US Patent


Assay Description
The inhibitory effects of compounds to be tested on double mutant EGFR kinase (EGFR T790M/L858R Kinase) (Invitrogen, PV4879) and wild-type EGFR kinas...


US Patent US10435400 (2019)


BindingDB Entry DOI: 10.7270/Q20V8G4V
More data for this
Ligand-Target Pair
Epidermal growth factor receptor(L858R, T790M)


(Homo sapiens (Human))
BDBM414547
PNG
(US10435400, Compound Z-19)
Show SMILES COc1cc(N(C)CCN(C)C)c(NC(=O)C=C)cc1Nc1ncc(Cl)c(n1)-c1cnn(C)c1
Show InChI InChI=1S/C23H29ClN8O2/c1-7-21(33)27-17-10-18(20(34-6)11-19(17)31(4)9-8-30(2)3)28-23-25-13-16(24)22(29-23)15-12-26-32(5)14-15/h7,10-14H,1,8-9H2,2-6H3,(H,27,33)(H,25,28,29)
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SHANGHAI HAIYAN PHARMACEUTICAL TECHNOLOGY CO. LTD.

US Patent


Assay Description
The inhibitory effects of compounds to be tested on double mutant EGFR kinase (EGFR T790M/L858R Kinase) (Invitrogen, PV4879) and wild-type EGFR kinas...


US Patent US10435400 (2019)


BindingDB Entry DOI: 10.7270/Q20V8G4V
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM414577
PNG
(US10435400, Compound Z-123)
Show SMILES COc1cc(N(C)CCN(C)C)c(NC(=O)C=C)cc1Nc1ncc(F)c(n1)-c1cnc2n(C)cc(Cl)c2c1
Show InChI InChI=1S/C27H30ClFN8O2/c1-7-24(38)32-20-11-21(23(39-6)12-22(20)36(4)9-8-35(2)3)33-27-31-14-19(29)25(34-27)16-10-17-18(28)15-37(5)26(17)30-13-16/h7,10-15H,1,8-9H2,2-6H3,(H,32,38)(H,31,33,34)
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SHANGHAI HAIYAN PHARMACEUTICAL TECHNOLOGY CO. LTD.

US Patent


Assay Description
The inhibitory effects of compounds to be tested on double mutant EGFR kinase (EGFR T790M/L858R Kinase) (Invitrogen, PV4879) and wild-type EGFR kinas...


US Patent US10435400 (2019)


BindingDB Entry DOI: 10.7270/Q20V8G4V
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM414544
PNG
(US10435400, Compound comparative)
Show SMILES COc1cc(N2CCC(CC2)N(C)C)c(NC(=O)C=C)cc1Nc1nccc(n1)-c1cccnc1
Show InChI InChI=1S/C26H31N7O2/c1-5-25(34)29-21-15-22(31-26-28-12-8-20(30-26)18-7-6-11-27-17-18)24(35-4)16-23(21)33-13-9-19(10-14-33)32(2)3/h5-8,11-12,15-17,19H,1,9-10,13-14H2,2-4H3,(H,29,34)(H,28,30,31)
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SHANGHAI HAIYAN PHARMACEUTICAL TECHNOLOGY CO. LTD.

US Patent


Assay Description
The inhibitory effects of compounds to be tested on double mutant EGFR kinase (EGFR T790M/L858R Kinase) (Invitrogen, PV4879) and wild-type EGFR kinas...


US Patent US10435400 (2019)


BindingDB Entry DOI: 10.7270/Q20V8G4V
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM414544
PNG
(US10435400, Compound comparative)
Show SMILES COc1cc(N2CCC(CC2)N(C)C)c(NC(=O)C=C)cc1Nc1nccc(n1)-c1cccnc1
Show InChI InChI=1S/C26H31N7O2/c1-5-25(34)29-21-15-22(31-26-28-12-8-20(30-26)18-7-6-11-27-17-18)24(35-4)16-23(21)33-13-9-19(10-14-33)32(2)3/h5-8,11-12,15-17,19H,1,9-10,13-14H2,2-4H3,(H,29,34)(H,28,30,31)
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SHANGHAI HAIYAN PHARMACEUTICAL TECHNOLOGY CO. LTD.

US Patent


Assay Description
The inhibitory effects of compounds to be tested on double mutant EGFR kinase (EGFR T790M/L858R Kinase) (Invitrogen, PV4879) and wild-type EGFR kinas...


US Patent US10435400 (2019)


BindingDB Entry DOI: 10.7270/Q20V8G4V
More data for this
Ligand-Target Pair
Epidermal growth factor receptor(L858R, T790M)


(Homo sapiens (Human))
BDBM414525
PNG
(N-(2-((2-(dimethylamino)ethyl)(methyl)amino)-4-met...)
Show SMILES COc1cc(N(C)CCN(C)C)c(NC(=O)C=C)cc1Nc1nccc(n1)-c1cnc2n(C)ccc2c1
Show InChI InChI=1S/C27H32N8O2/c1-7-25(36)30-21-15-22(24(37-6)16-23(21)34(4)13-12-33(2)3)32-27-28-10-8-20(31-27)19-14-18-9-11-35(5)26(18)29-17-19/h7-11,14-17H,1,12-13H2,2-6H3,(H,30,36)(H,28,31,32)
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SHANGHAI HAIYAN PHARMACEUTICAL TECHNOLOGY CO. LTD.

US Patent


Assay Description
The inhibitory effects of compounds to be tested on double mutant EGFR kinase (EGFR T790M/L858R Kinase) (Invitrogen, PV4879) and wild-type EGFR kinas...


US Patent US10435400 (2019)


BindingDB Entry DOI: 10.7270/Q20V8G4V
More data for this
Ligand-Target Pair
Epidermal growth factor receptor(L858R, T790M)


(Homo sapiens (Human))
BDBM414563
PNG
(US10435400, Compound Z-105)
Show SMILES CCN(C)CCN(C)c1cc(OC)c(Nc2nccc(n2)-c2cnc3n(C)ccc3c2)cc1NC(=O)C=C
Show InChI InChI=1S/C28H34N8O2/c1-7-26(37)31-22-16-23(25(38-6)17-24(22)35(4)14-13-34(3)8-2)33-28-29-11-9-21(32-28)20-15-19-10-12-36(5)27(19)30-18-20/h7,9-12,15-18H,1,8,13-14H2,2-6H3,(H,31,37)(H,29,32,33)
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SHANGHAI HAIYAN PHARMACEUTICAL TECHNOLOGY CO. LTD.

US Patent


Assay Description
The inhibitory effects of compounds to be tested on double mutant EGFR kinase (EGFR T790M/L858R Kinase) (Invitrogen, PV4879) and wild-type EGFR kinas...


US Patent US10435400 (2019)


BindingDB Entry DOI: 10.7270/Q20V8G4V
More data for this
Ligand-Target Pair
Epidermal growth factor receptor(L858R, T790M)


(Homo sapiens (Human))
BDBM414575
PNG
(US10435400, Compound Z-121)
Show SMILES COc1cc(N(C)CCN(C)C)c(NC(=O)C=C)cc1Nc1ncc(Cl)c(n1)-c1cnc2n(C)cc(Cl)c2c1
Show InChI InChI=1S/C27H30Cl2N8O2/c1-7-24(38)32-20-11-21(23(39-6)12-22(20)36(4)9-8-35(2)3)33-27-31-14-18(28)25(34-27)16-10-17-19(29)15-37(5)26(17)30-13-16/h7,10-15H,1,8-9H2,2-6H3,(H,32,38)(H,31,33,34)
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SHANGHAI HAIYAN PHARMACEUTICAL TECHNOLOGY CO. LTD.

US Patent


Assay Description
The inhibitory effects of compounds to be tested on double mutant EGFR kinase (EGFR T790M/L858R Kinase) (Invitrogen, PV4879) and wild-type EGFR kinas...


US Patent US10435400 (2019)


BindingDB Entry DOI: 10.7270/Q20V8G4V
More data for this
Ligand-Target Pair
Epidermal growth factor receptor(L858R, T790M)


(Homo sapiens (Human))
BDBM414520
PNG
(N-(5-(5-chloro-4-(1-methyl-1H-pyrrolo[2,3-b]pyridi...)
Show SMILES COc1cc(N(C)CCN(C)C)c(NC(=O)C=C)cc1Nc1ncc(Cl)c(n1)-c1cnc2n(C)ccc2c1
Show InChI InChI=1S/C27H31ClN8O2/c1-7-24(37)31-20-13-21(23(38-6)14-22(20)35(4)11-10-34(2)3)32-27-30-16-19(28)25(33-27)18-12-17-8-9-36(5)26(17)29-15-18/h7-9,12-16H,1,10-11H2,2-6H3,(H,31,37)(H,30,32,33)
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SHANGHAI HAIYAN PHARMACEUTICAL TECHNOLOGY CO. LTD.

US Patent


Assay Description
The inhibitory effects of compounds to be tested on double mutant EGFR kinase (EGFR T790M/L858R Kinase) (Invitrogen, PV4879) and wild-type EGFR kinas...


US Patent US10435400 (2019)


BindingDB Entry DOI: 10.7270/Q20V8G4V
More data for this
Ligand-Target Pair
Epidermal growth factor receptor(L858R, T790M)


(Homo sapiens (Human))
BDBM414532
PNG
(US10435400, Compound Z-27)
Show SMILES COc1cc(N2CC(C2)N(C)C)c(NC(=O)C=C)cc1Nc1nccc(n1)-c1cnc2n(C)ccc2c1
Show InChI InChI=1S/C27H30N8O2/c1-6-25(36)30-21-12-22(24(37-5)13-23(21)35-15-19(16-35)33(2)3)32-27-28-9-7-20(31-27)18-11-17-8-10-34(4)26(17)29-14-18/h6-14,19H,1,15-16H2,2-5H3,(H,30,36)(H,28,31,32)
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SHANGHAI HAIYAN PHARMACEUTICAL TECHNOLOGY CO. LTD.

US Patent


Assay Description
The inhibitory effects of compounds to be tested on double mutant EGFR kinase (EGFR T790M/L858R Kinase) (Invitrogen, PV4879) and wild-type EGFR kinas...


US Patent US10435400 (2019)


BindingDB Entry DOI: 10.7270/Q20V8G4V
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM414526
PNG
(US10435400, Compound Z-20)
Show SMILES COc1cc(N(C)CCN(C)N)c(NC(=O)C=C)cc1Nc1ncc(F)c(n1)-c1cnc2n(C)ccc2c1
Show InChI InChI=1S/C26H30FN9O2/c1-6-23(37)31-19-12-20(22(38-5)13-21(19)34(2)9-10-36(4)28)32-26-30-15-18(27)24(33-26)17-11-16-7-8-35(3)25(16)29-14-17/h6-8,11-15H,1,9-10,28H2,2-5H3,(H,31,37)(H,30,32,33)
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SHANGHAI HAIYAN PHARMACEUTICAL TECHNOLOGY CO. LTD.

US Patent


Assay Description
The inhibitory effects of compounds to be tested on double mutant EGFR kinase (EGFR T790M/L858R Kinase) (Invitrogen, PV4879) and wild-type EGFR kinas...


US Patent US10435400 (2019)


BindingDB Entry DOI: 10.7270/Q20V8G4V
More data for this
Ligand-Target Pair
Epidermal growth factor receptor(L858R, T790M)


(Homo sapiens (Human))
BDBM414559
PNG
(US10435400, Compound Z-99)
Show SMILES COc1cc(N(C)CCN(C)C)c(NC(=O)C=C)cc1Nc1ncc(Cl)c(n1)-c1ccn(C)c1
Show InChI InChI=1S/C24H30ClN7O2/c1-7-22(33)27-18-12-19(21(34-6)13-20(18)32(5)11-10-30(2)3)28-24-26-14-17(25)23(29-24)16-8-9-31(4)15-16/h7-9,12-15H,1,10-11H2,2-6H3,(H,27,33)(H,26,28,29)
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SHANGHAI HAIYAN PHARMACEUTICAL TECHNOLOGY CO. LTD.

US Patent


Assay Description
The inhibitory effects of compounds to be tested on double mutant EGFR kinase (EGFR T790M/L858R Kinase) (Invitrogen, PV4879) and wild-type EGFR kinas...


US Patent US10435400 (2019)


BindingDB Entry DOI: 10.7270/Q20V8G4V
More data for this
Ligand-Target Pair
Epidermal growth factor receptor(L858R, T790M)


(Homo sapiens (Human))
BDBM414524
PNG
(N-(2-((2-(dimethylamino)ethyl)(methyl)amino)-4-met...)
Show SMILES COc1cc(N(C)CCN(C)C)c(NC(=O)C=C)cc1Nc1nccc(n1)-c1cnc2n(C)ncc2c1
Show InChI InChI=1S/C26H31N9O2/c1-7-24(36)30-20-13-21(23(37-6)14-22(20)34(4)11-10-33(2)3)32-26-27-9-8-19(31-26)17-12-18-16-29-35(5)25(18)28-15-17/h7-9,12-16H,1,10-11H2,2-6H3,(H,30,36)(H,27,31,32)
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SHANGHAI HAIYAN PHARMACEUTICAL TECHNOLOGY CO. LTD.

US Patent


Assay Description
The inhibitory effects of compounds to be tested on double mutant EGFR kinase (EGFR T790M/L858R Kinase) (Invitrogen, PV4879) and wild-type EGFR kinas...


US Patent US10435400 (2019)


BindingDB Entry DOI: 10.7270/Q20V8G4V
More data for this
Ligand-Target Pair
Epidermal growth factor receptor(L858R, T790M)


(Homo sapiens (Human))
BDBM414578
PNG
(US10435400, Compound Z-124)
Show SMILES COc1cc(N(C)CCN(C)C)c(NC(=O)C=C)cc1Nc1nccc(n1)-c1cnc2n(ccc2c1)C(C)C
Show InChI InChI=1S/C29H36N8O2/c1-8-27(38)32-23-16-24(26(39-7)17-25(23)36(6)14-13-35(4)5)34-29-30-11-9-22(33-29)21-15-20-10-12-37(19(2)3)28(20)31-18-21/h8-12,15-19H,1,13-14H2,2-7H3,(H,32,38)(H,30,33,34)
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SHANGHAI HAIYAN PHARMACEUTICAL TECHNOLOGY CO. LTD.

US Patent


Assay Description
The inhibitory effects of compounds to be tested on double mutant EGFR kinase (EGFR T790M/L858R Kinase) (Invitrogen, PV4879) and wild-type EGFR kinas...


US Patent US10435400 (2019)


BindingDB Entry DOI: 10.7270/Q20V8G4V
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM414564
PNG
(US10435400, Compound Z-106)
Show SMILES CNCCN(C)c1cc(OC)c(Nc2nccc(n2)-c2cnc3n(C)ccc3c2)cc1NC(=O)C=C
Show InChI InChI=1S/C26H30N8O2/c1-6-24(35)30-20-14-21(23(36-5)15-22(20)33(3)12-10-27-2)32-26-28-9-7-19(31-26)18-13-17-8-11-34(4)25(17)29-16-18/h6-9,11,13-16,27H,1,10,12H2,2-5H3,(H,30,35)(H,28,31,32)
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SHANGHAI HAIYAN PHARMACEUTICAL TECHNOLOGY CO. LTD.

US Patent


Assay Description
The inhibitory effects of compounds to be tested on double mutant EGFR kinase (EGFR T790M/L858R Kinase) (Invitrogen, PV4879) and wild-type EGFR kinas...


US Patent US10435400 (2019)


BindingDB Entry DOI: 10.7270/Q20V8G4V
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM414525
PNG
(N-(2-((2-(dimethylamino)ethyl)(methyl)amino)-4-met...)
Show SMILES COc1cc(N(C)CCN(C)C)c(NC(=O)C=C)cc1Nc1nccc(n1)-c1cnc2n(C)ccc2c1
Show InChI InChI=1S/C27H32N8O2/c1-7-25(36)30-21-15-22(24(37-6)16-23(21)34(4)13-12-33(2)3)32-27-28-10-8-20(31-27)19-14-18-9-11-35(5)26(18)29-17-19/h7-11,14-17H,1,12-13H2,2-6H3,(H,30,36)(H,28,31,32)
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SHANGHAI HAIYAN PHARMACEUTICAL TECHNOLOGY CO. LTD.

US Patent


Assay Description
The inhibitory effects of compounds to be tested on double mutant EGFR kinase (EGFR T790M/L858R Kinase) (Invitrogen, PV4879) and wild-type EGFR kinas...


US Patent US10435400 (2019)


BindingDB Entry DOI: 10.7270/Q20V8G4V
More data for this
Ligand-Target Pair
Epidermal growth factor receptor(L858R, T790M)


(Homo sapiens (Human))
BDBM414565
PNG
(US10435400, Compound Z-107)
Show SMILES CCN(CC)CCN(C)c1cc(OC)c(Nc2nccc(n2)-c2cnc3n(C)ccc3c2)cc1NC(=O)C=C
Show InChI InChI=1S/C29H36N8O2/c1-7-27(38)32-23-17-24(26(39-6)18-25(23)35(4)14-15-37(8-2)9-3)34-29-30-12-10-22(33-29)21-16-20-11-13-36(5)28(20)31-19-21/h7,10-13,16-19H,1,8-9,14-15H2,2-6H3,(H,32,38)(H,30,33,34)
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SHANGHAI HAIYAN PHARMACEUTICAL TECHNOLOGY CO. LTD.

US Patent


Assay Description
The inhibitory effects of compounds to be tested on double mutant EGFR kinase (EGFR T790M/L858R Kinase) (Invitrogen, PV4879) and wild-type EGFR kinas...


US Patent US10435400 (2019)


BindingDB Entry DOI: 10.7270/Q20V8G4V
More data for this
Ligand-Target Pair
Epidermal growth factor receptor(L858R, T790M)


(Homo sapiens (Human))
BDBM414548
PNG
(US10435400, Compound Z-89)
Show SMILES COc1cc(N2CCC(CC2)N(C)C)c(NC(=O)C=C)cc1Nc1ncc(Cl)c(n1)-c1cnn(C)c1
Show InChI InChI=1S/C25H31ClN8O2/c1-6-23(35)29-19-11-20(22(36-5)12-21(19)34-9-7-17(8-10-34)32(2)3)30-25-27-14-18(26)24(31-25)16-13-28-33(4)15-16/h6,11-15,17H,1,7-10H2,2-5H3,(H,29,35)(H,27,30,31)
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SHANGHAI HAIYAN PHARMACEUTICAL TECHNOLOGY CO. LTD.

US Patent


Assay Description
The inhibitory effects of compounds to be tested on double mutant EGFR kinase (EGFR T790M/L858R Kinase) (Invitrogen, PV4879) and wild-type EGFR kinas...


US Patent US10435400 (2019)


BindingDB Entry DOI: 10.7270/Q20V8G4V
More data for this
Ligand-Target Pair
Epidermal growth factor receptor(L858R, T790M)


(Homo sapiens (Human))
BDBM414537
PNG
(US10435400, Compound Z-39)
Show SMILES COc1cc(N(C)CCN(C)C)c(NC(=O)C=C)cc1Nc1ncc(Cl)c(n1)-c1cnc2n(C)ncc2c1
Show InChI InChI=1S/C26H30ClN9O2/c1-7-23(37)31-19-11-20(22(38-6)12-21(19)35(4)9-8-34(2)3)32-26-29-15-18(27)24(33-26)16-10-17-14-30-36(5)25(17)28-13-16/h7,10-15H,1,8-9H2,2-6H3,(H,31,37)(H,29,32,33)
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SHANGHAI HAIYAN PHARMACEUTICAL TECHNOLOGY CO. LTD.

US Patent


Assay Description
The inhibitory effects of compounds to be tested on double mutant EGFR kinase (EGFR T790M/L858R Kinase) (Invitrogen, PV4879) and wild-type EGFR kinas...


US Patent US10435400 (2019)


BindingDB Entry DOI: 10.7270/Q20V8G4V
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM414534
PNG
(US10435400, Compound Z-32)
Show SMILES COc1cc(N(C)CCN(C)C)c(NC(=O)C=C)cc1Nc1ncc(C(C)=O)c(n1)-c1cnc2n(C)ccc2c1
Show InChI InChI=1S/C29H34N8O3/c1-8-26(39)32-22-14-23(25(40-7)15-24(22)36(5)12-11-35(3)4)33-29-31-17-21(18(2)38)27(34-29)20-13-19-9-10-37(6)28(19)30-16-20/h8-10,13-17H,1,11-12H2,2-7H3,(H,32,39)(H,31,33,34)
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SHANGHAI HAIYAN PHARMACEUTICAL TECHNOLOGY CO. LTD.

US Patent


Assay Description
The inhibitory effects of compounds to be tested on double mutant EGFR kinase (EGFR T790M/L858R Kinase) (Invitrogen, PV4879) and wild-type EGFR kinas...


US Patent US10435400 (2019)


BindingDB Entry DOI: 10.7270/Q20V8G4V
More data for this
Ligand-Target Pair
Epidermal growth factor receptor(L858R, T790M)


(Homo sapiens (Human))
BDBM414528
PNG
(N-(2-((2-(dimethylamino)ethyl)(methyl)amino)-4-met...)
Show SMILES COc1cc(N(C)CCN(C)C)c(NC(=O)C=C)cc1Nc1ncc(OC)c(n1)-c1cnc2n(C)ccc2c1
Show InChI InChI=1S/C28H34N8O3/c1-8-25(37)31-20-14-21(23(38-6)15-22(20)35(4)12-11-34(2)3)32-28-30-17-24(39-7)26(33-28)19-13-18-9-10-36(5)27(18)29-16-19/h8-10,13-17H,1,11-12H2,2-7H3,(H,31,37)(H,30,32,33)
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SHANGHAI HAIYAN PHARMACEUTICAL TECHNOLOGY CO. LTD.

US Patent


Assay Description
The inhibitory effects of compounds to be tested on double mutant EGFR kinase (EGFR T790M/L858R Kinase) (Invitrogen, PV4879) and wild-type EGFR kinas...


US Patent US10435400 (2019)


BindingDB Entry DOI: 10.7270/Q20V8G4V
More data for this
Ligand-Target Pair
Epidermal growth factor receptor(L858R, T790M)


(Homo sapiens (Human))
BDBM414535
PNG
(US10435400, Compound Z-37)
Show SMILES COc1cc(N2CCC(CC2)N(C)C)c(NC(=O)C=C)cc1Nc1ncc(F)c(n1)-c1cnc2n(C)ncc2c1
Show InChI InChI=1S/C28H32FN9O2/c1-6-25(39)33-21-12-22(24(40-5)13-23(21)38-9-7-19(8-10-38)36(2)3)34-28-31-16-20(29)26(35-28)17-11-18-15-32-37(4)27(18)30-14-17/h6,11-16,19H,1,7-10H2,2-5H3,(H,33,39)(H,31,34,35)
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SHANGHAI HAIYAN PHARMACEUTICAL TECHNOLOGY CO. LTD.

US Patent


Assay Description
The inhibitory effects of compounds to be tested on double mutant EGFR kinase (EGFR T790M/L858R Kinase) (Invitrogen, PV4879) and wild-type EGFR kinas...


US Patent US10435400 (2019)


BindingDB Entry DOI: 10.7270/Q20V8G4V
More data for this
Ligand-Target Pair
Epidermal growth factor receptor(L858R, T790M)


(Homo sapiens (Human))
BDBM414576
PNG
(US10435400, Compound Z-122)
Show SMILES COc1cc(N2CCC(CC2)N(C)C)c(NC(=O)C=C)cc1Nc1ncc(F)c(n1)-c1cnc2n(C)cc(Cl)c2c1
Show InChI InChI=1S/C29H32ClFN8O2/c1-6-26(40)34-22-12-23(25(41-5)13-24(22)39-9-7-18(8-10-39)37(2)3)35-29-33-15-21(31)27(36-29)17-11-19-20(30)16-38(4)28(19)32-14-17/h6,11-16,18H,1,7-10H2,2-5H3,(H,34,40)(H,33,35,36)
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SHANGHAI HAIYAN PHARMACEUTICAL TECHNOLOGY CO. LTD.

US Patent


Assay Description
The inhibitory effects of compounds to be tested on double mutant EGFR kinase (EGFR T790M/L858R Kinase) (Invitrogen, PV4879) and wild-type EGFR kinas...


US Patent US10435400 (2019)


BindingDB Entry DOI: 10.7270/Q20V8G4V
More data for this
Ligand-Target Pair
Epidermal growth factor receptor(L858R, T790M)


(Homo sapiens (Human))
BDBM50322823
PNG
((S)-N-(4-(3-chloro-4-fluorophenylamino)-7-(tetrahy...)
Show SMILES CN(C)C\C=C\C(=O)Nc1cc2c(Nc3ccc(F)c(Cl)c3)ncnc2cc1O[C@H]1CCOC1
Show InChI InChI=1S/C24H25ClFN5O3/c1-31(2)8-3-4-23(32)30-21-11-17-20(12-22(21)34-16-7-9-33-13-16)27-14-28-24(17)29-15-5-6-19(26)18(25)10-15/h3-6,10-12,14,16H,7-9,13H2,1-2H3,(H,30,32)(H,27,28,29)/b4-3+/t16-/m0/s1
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SHANGHAI HAIYAN PHARMACEUTICAL TECHNOLOGY CO. LTD.

US Patent


Assay Description
The inhibitory effects of compounds to be tested on double mutant EGFR kinase (EGFR T790M/L858R Kinase) (Invitrogen, PV4879) and wild-type EGFR kinas...


US Patent US10435400 (2019)


BindingDB Entry DOI: 10.7270/Q20V8G4V
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM414574
PNG
(US10435400, Compound Z-118)
Show SMILES COc1cc(OCCN(C)C)c(NC(=O)C=C)cc1Nc1ncc(F)c(n1)-c1cnc2n(C)ccc2c1
Show InChI InChI=1S/C26H28FN7O3/c1-6-23(35)30-20-12-19(21(36-5)13-22(20)37-10-9-33(2)3)31-26-29-15-18(27)24(32-26)17-11-16-7-8-34(4)25(16)28-14-17/h6-8,11-15H,1,9-10H2,2-5H3,(H,30,35)(H,29,31,32)
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SHANGHAI HAIYAN PHARMACEUTICAL TECHNOLOGY CO. LTD.

US Patent


Assay Description
The inhibitory effects of compounds to be tested on double mutant EGFR kinase (EGFR T790M/L858R Kinase) (Invitrogen, PV4879) and wild-type EGFR kinas...


US Patent US10435400 (2019)


BindingDB Entry DOI: 10.7270/Q20V8G4V
More data for this
Ligand-Target Pair
Epidermal growth factor receptor(L858R, T790M)


(Homo sapiens (Human))
BDBM414572
PNG
(US10435400, Compound Z-116)
Show SMILES CNCCN(C)c1cc(OC)c(Nc2ncc(Cl)c(n2)-c2cnc3n(C)ccc3c2)cc1NC(=O)C=C
Show InChI InChI=1S/C26H29ClN8O2/c1-6-23(36)31-19-12-20(22(37-5)13-21(19)34(3)10-8-28-2)32-26-30-15-18(27)24(33-26)17-11-16-7-9-35(4)25(16)29-14-17/h6-7,9,11-15,28H,1,8,10H2,2-5H3,(H,31,36)(H,30,32,33)
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SHANGHAI HAIYAN PHARMACEUTICAL TECHNOLOGY CO. LTD.

US Patent


Assay Description
The inhibitory effects of compounds to be tested on double mutant EGFR kinase (EGFR T790M/L858R Kinase) (Invitrogen, PV4879) and wild-type EGFR kinas...


US Patent US10435400 (2019)


BindingDB Entry DOI: 10.7270/Q20V8G4V
More data for this
Ligand-Target Pair
Epidermal growth factor receptor(L858R, T790M)


(Homo sapiens (Human))
BDBM414566
PNG
(US10435400, Compound Z-109)
Show SMILES CCN(C)CCN(C)c1cc(OC)c(Nc2ncc(Cl)c(n2)-c2cnc3n(C)ccc3c2)cc1NC(=O)C=C
Show InChI InChI=1S/C28H33ClN8O2/c1-7-25(38)32-21-14-22(24(39-6)15-23(21)36(4)12-11-35(3)8-2)33-28-31-17-20(29)26(34-28)19-13-18-9-10-37(5)27(18)30-16-19/h7,9-10,13-17H,1,8,11-12H2,2-6H3,(H,32,38)(H,31,33,34)
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SHANGHAI HAIYAN PHARMACEUTICAL TECHNOLOGY CO. LTD.

US Patent


Assay Description
The inhibitory effects of compounds to be tested on double mutant EGFR kinase (EGFR T790M/L858R Kinase) (Invitrogen, PV4879) and wild-type EGFR kinas...


US Patent US10435400 (2019)


BindingDB Entry DOI: 10.7270/Q20V8G4V
More data for this
Ligand-Target Pair
Epidermal growth factor receptor(L858R, T790M)


(Homo sapiens (Human))
BDBM414571
PNG
(US10435400, Compound Z-115)
Show SMILES COc1cc(N(C)CCN(C)C(C)C)c(NC(=O)C=C)cc1Nc1nccc(n1)-c1cnc2n(C)ccc2c1
Show InChI InChI=1S/C29H36N8O2/c1-8-27(38)32-23-16-24(26(39-7)17-25(23)36(5)14-13-35(4)19(2)3)34-29-30-11-9-22(33-29)21-15-20-10-12-37(6)28(20)31-18-21/h8-12,15-19H,1,13-14H2,2-7H3,(H,32,38)(H,30,33,34)
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SHANGHAI HAIYAN PHARMACEUTICAL TECHNOLOGY CO. LTD.

US Patent


Assay Description
The inhibitory effects of compounds to be tested on double mutant EGFR kinase (EGFR T790M/L858R Kinase) (Invitrogen, PV4879) and wild-type EGFR kinas...


US Patent US10435400 (2019)


BindingDB Entry DOI: 10.7270/Q20V8G4V
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM414563
PNG
(US10435400, Compound Z-105)
Show SMILES CCN(C)CCN(C)c1cc(OC)c(Nc2nccc(n2)-c2cnc3n(C)ccc3c2)cc1NC(=O)C=C
Show InChI InChI=1S/C28H34N8O2/c1-7-26(37)31-22-16-23(25(38-6)17-24(22)35(4)14-13-34(3)8-2)33-28-29-11-9-21(32-28)20-15-19-10-12-36(5)27(19)30-18-20/h7,9-12,15-18H,1,8,13-14H2,2-6H3,(H,31,37)(H,29,32,33)
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SHANGHAI HAIYAN PHARMACEUTICAL TECHNOLOGY CO. LTD.

US Patent


Assay Description
The inhibitory effects of compounds to be tested on double mutant EGFR kinase (EGFR T790M/L858R Kinase) (Invitrogen, PV4879) and wild-type EGFR kinas...


US Patent US10435400 (2019)


BindingDB Entry DOI: 10.7270/Q20V8G4V
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM414580
PNG
(US10435400, Compound Z-126)
Show SMILES COc1cc(N(C)CCN(C)C)c(NC(=O)C=C)cc1Nc1ncc(Cl)c(n1)-c1cnc2n(ccc2c1)C1CC1
Show InChI InChI=1S/C29H33ClN8O2/c1-6-26(39)33-22-14-23(25(40-5)15-24(22)37(4)12-11-36(2)3)34-29-32-17-21(30)27(35-29)19-13-18-9-10-38(20-7-8-20)28(18)31-16-19/h6,9-10,13-17,20H,1,7-8,11-12H2,2-5H3,(H,33,39)(H,32,34,35)
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SHANGHAI HAIYAN PHARMACEUTICAL TECHNOLOGY CO. LTD.

US Patent


Assay Description
The inhibitory effects of compounds to be tested on double mutant EGFR kinase (EGFR T790M/L858R Kinase) (Invitrogen, PV4879) and wild-type EGFR kinas...


US Patent US10435400 (2019)


BindingDB Entry DOI: 10.7270/Q20V8G4V
More data for this
Ligand-Target Pair
Epidermal growth factor receptor(L858R, T790M)


(Homo sapiens (Human))
BDBM414568
PNG
(US10435400, Compound Z-112)
Show SMILES COc1cc(N(C)CCN2CCCC2)c(NC(=O)C=C)cc1Nc1nccc(n1)-c1cnc2n(C)ccc2c1
Show InChI InChI=1S/C29H34N8O2/c1-5-27(38)32-23-17-24(26(39-4)18-25(23)35(2)14-15-37-11-6-7-12-37)34-29-30-10-8-22(33-29)21-16-20-9-13-36(3)28(20)31-19-21/h5,8-10,13,16-19H,1,6-7,11-12,14-15H2,2-4H3,(H,32,38)(H,30,33,34)
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SHANGHAI HAIYAN PHARMACEUTICAL TECHNOLOGY CO. LTD.

US Patent


Assay Description
The inhibitory effects of compounds to be tested on double mutant EGFR kinase (EGFR T790M/L858R Kinase) (Invitrogen, PV4879) and wild-type EGFR kinas...


US Patent US10435400 (2019)


BindingDB Entry DOI: 10.7270/Q20V8G4V
More data for this
Ligand-Target Pair
Epidermal growth factor receptor(L858R, T790M)


(Homo sapiens (Human))
BDBM414567
PNG
(US10435400, Compound Z-110)
Show SMILES CCN(CC)CCN(C)c1cc(OC)c(Nc2ncc(Cl)c(n2)-c2cnc3n(C)ccc3c2)cc1NC(=O)C=C
Show InChI InChI=1S/C29H35ClN8O2/c1-7-26(39)33-22-15-23(25(40-6)16-24(22)36(4)12-13-38(8-2)9-3)34-29-32-18-21(30)27(35-29)20-14-19-10-11-37(5)28(19)31-17-20/h7,10-11,14-18H,1,8-9,12-13H2,2-6H3,(H,33,39)(H,32,34,35)
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SHANGHAI HAIYAN PHARMACEUTICAL TECHNOLOGY CO. LTD.

US Patent


Assay Description
The inhibitory effects of compounds to be tested on double mutant EGFR kinase (EGFR T790M/L858R Kinase) (Invitrogen, PV4879) and wild-type EGFR kinas...


US Patent US10435400 (2019)


BindingDB Entry DOI: 10.7270/Q20V8G4V
More data for this
Ligand-Target Pair
Epidermal growth factor receptor(L858R, T790M)


(Homo sapiens (Human))
BDBM414561
PNG
(US10435400, Compound Z-101)
Show SMILES COc1cc(N2CCC(CC2)N(C)C)c(NC(=O)C=C)cc1Nc1ncc(Cl)c(n1)-c1cnn(c1)C(F)F
Show InChI InChI=1S/C25H29ClF2N8O2/c1-5-22(37)31-18-10-19(21(38-4)11-20(18)35-8-6-16(7-9-35)34(2)3)32-25-29-13-17(26)23(33-25)15-12-30-36(14-15)24(27)28/h5,10-14,16,24H,1,6-9H2,2-4H3,(H,31,37)(H,29,32,33)
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SHANGHAI HAIYAN PHARMACEUTICAL TECHNOLOGY CO. LTD.

US Patent


Assay Description
The inhibitory effects of compounds to be tested on double mutant EGFR kinase (EGFR T790M/L858R Kinase) (Invitrogen, PV4879) and wild-type EGFR kinas...


US Patent US10435400 (2019)


BindingDB Entry DOI: 10.7270/Q20V8G4V
More data for this
Ligand-Target Pair
Epidermal growth factor receptor(L858R, T790M)


(Homo sapiens (Human))
BDBM414550
PNG
(US10435400, Compound Z-90)
Show SMILES COc1cc(N2CCC(CC2)N(C)C)c(NC(=O)C=C)cc1Nc1ncc(F)c(n1)-c1cnn(C)c1
Show InChI InChI=1S/C25H31FN8O2/c1-6-23(35)29-19-11-20(22(36-5)12-21(19)34-9-7-17(8-10-34)32(2)3)30-25-27-14-18(26)24(31-25)16-13-28-33(4)15-16/h6,11-15,17H,1,7-10H2,2-5H3,(H,29,35)(H,27,30,31)
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SHANGHAI HAIYAN PHARMACEUTICAL TECHNOLOGY CO. LTD.

US Patent


Assay Description
The inhibitory effects of compounds to be tested on double mutant EGFR kinase (EGFR T790M/L858R Kinase) (Invitrogen, PV4879) and wild-type EGFR kinas...


US Patent US10435400 (2019)


BindingDB Entry DOI: 10.7270/Q20V8G4V
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM414525
PNG
(N-(2-((2-(dimethylamino)ethyl)(methyl)amino)-4-met...)
Show SMILES COc1cc(N(C)CCN(C)C)c(NC(=O)C=C)cc1Nc1nccc(n1)-c1cnc2n(C)ccc2c1
Show InChI InChI=1S/C27H32N8O2/c1-7-25(36)30-21-15-22(24(37-6)16-23(21)34(4)13-12-33(2)3)32-27-28-10-8-20(31-27)19-14-18-9-11-35(5)26(18)29-17-19/h7-11,14-17H,1,12-13H2,2-6H3,(H,30,36)(H,28,31,32)
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SHANGHAI HAIYAN PHARMACEUTICAL TECHNOLOGY CO. LTD.

US Patent


Assay Description
The inhibitory effects of compounds to be tested on double mutant EGFR kinase (EGFR T790M/L858R Kinase) (Invitrogen, PV4879) and wild-type EGFR kinas...


US Patent US10435400 (2019)


BindingDB Entry DOI: 10.7270/Q20V8G4V
More data for this
Ligand-Target Pair
Epidermal growth factor receptor(L858R, T790M)


(Homo sapiens (Human))
BDBM414540
PNG
(US10435400, Compound Z-44)
Show SMILES COc1cc(N(C)CCN(C)C)c(NC(=O)C=C)cc1Nc1ncc(OC)c(n1)-c1cnc2n(C)ncc2c1
Show InChI InChI=1S/C27H33N9O3/c1-8-24(37)31-19-12-20(22(38-6)13-21(19)35(4)10-9-34(2)3)32-27-29-16-23(39-7)25(33-27)17-11-18-15-30-36(5)26(18)28-14-17/h8,11-16H,1,9-10H2,2-7H3,(H,31,37)(H,29,32,33)
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SHANGHAI HAIYAN PHARMACEUTICAL TECHNOLOGY CO. LTD.

US Patent


Assay Description
The inhibitory effects of compounds to be tested on double mutant EGFR kinase (EGFR T790M/L858R Kinase) (Invitrogen, PV4879) and wild-type EGFR kinas...


US Patent US10435400 (2019)


BindingDB Entry DOI: 10.7270/Q20V8G4V
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM414573
PNG
(US10435400, Compound Z-117)
Show SMILES COc1cc(OCCN(C)C)c(NC(=O)C=C)cc1Nc1nccc(n1)-c1cnc2n(C)ccc2c1
Show InChI InChI=1S/C26H29N7O3/c1-6-24(34)29-21-14-20(22(35-5)15-23(21)36-12-11-32(2)3)31-26-27-9-7-19(30-26)18-13-17-8-10-33(4)25(17)28-16-18/h6-10,13-16H,1,11-12H2,2-5H3,(H,29,34)(H,27,30,31)
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n/an/a 8n/an/an/an/an/an/a



SHANGHAI HAIYAN PHARMACEUTICAL TECHNOLOGY CO. LTD.

US Patent


Assay Description
The inhibitory effects of compounds to be tested on double mutant EGFR kinase (EGFR T790M/L858R Kinase) (Invitrogen, PV4879) and wild-type EGFR kinas...


US Patent US10435400 (2019)


BindingDB Entry DOI: 10.7270/Q20V8G4V
More data for this
Ligand-Target Pair
Epidermal growth factor receptor(L858R, T790M)


(Homo sapiens (Human))
BDBM414529
PNG
(N-(2-((2-(dimethylamino)ethyl)(methyl)amino)-4-met...)
Show SMILES COc1cc(N(C)CCN(C)C)c(NC(=O)C=C)cc1Nc1ncc(c(n1)-c1cnc2n(C)ccc2c1)C(F)(F)F
Show InChI InChI=1S/C28H31F3N8O2/c1-7-24(40)34-20-13-21(23(41-6)14-22(20)38(4)11-10-37(2)3)35-27-33-16-19(28(29,30)31)25(36-27)18-12-17-8-9-39(5)26(17)32-15-18/h7-9,12-16H,1,10-11H2,2-6H3,(H,34,40)(H,33,35,36)
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n/an/a 9n/an/an/an/an/an/a



SHANGHAI HAIYAN PHARMACEUTICAL TECHNOLOGY CO. LTD.

US Patent


Assay Description
The inhibitory effects of compounds to be tested on double mutant EGFR kinase (EGFR T790M/L858R Kinase) (Invitrogen, PV4879) and wild-type EGFR kinas...


US Patent US10435400 (2019)


BindingDB Entry DOI: 10.7270/Q20V8G4V
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM414528
PNG
(N-(2-((2-(dimethylamino)ethyl)(methyl)amino)-4-met...)
Show SMILES COc1cc(N(C)CCN(C)C)c(NC(=O)C=C)cc1Nc1ncc(OC)c(n1)-c1cnc2n(C)ccc2c1
Show InChI InChI=1S/C28H34N8O3/c1-8-25(37)31-20-14-21(23(38-6)15-22(20)35(4)12-11-34(2)3)32-28-30-17-24(39-7)26(33-28)19-13-18-9-10-36(5)27(18)29-16-19/h8-10,13-17H,1,11-12H2,2-7H3,(H,31,37)(H,30,32,33)
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n/an/a 9n/an/an/an/an/an/a



SHANGHAI HAIYAN PHARMACEUTICAL TECHNOLOGY CO. LTD.

US Patent


Assay Description
The inhibitory effects of compounds to be tested on double mutant EGFR kinase (EGFR T790M/L858R Kinase) (Invitrogen, PV4879) and wild-type EGFR kinas...


US Patent US10435400 (2019)


BindingDB Entry DOI: 10.7270/Q20V8G4V
More data for this
Ligand-Target Pair
Epidermal growth factor receptor(L858R, T790M)


(Homo sapiens (Human))
BDBM414539
PNG
(US10435400, Compound Z-41)
Show SMILES COc1cc(N(C)CCN(C)C)c(NC(=O)C=C)cc1Nc1ncc(F)c(n1)-c1cnc2n(C)ncc2c1
Show InChI InChI=1S/C26H30FN9O2/c1-7-23(37)31-19-11-20(22(38-6)12-21(19)35(4)9-8-34(2)3)32-26-29-15-18(27)24(33-26)16-10-17-14-30-36(5)25(17)28-13-16/h7,10-15H,1,8-9H2,2-6H3,(H,31,37)(H,29,32,33)
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n/an/a 9n/an/an/an/an/an/a



SHANGHAI HAIYAN PHARMACEUTICAL TECHNOLOGY CO. LTD.

US Patent


Assay Description
The inhibitory effects of compounds to be tested on double mutant EGFR kinase (EGFR T790M/L858R Kinase) (Invitrogen, PV4879) and wild-type EGFR kinas...


US Patent US10435400 (2019)


BindingDB Entry DOI: 10.7270/Q20V8G4V
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM414524
PNG
(N-(2-((2-(dimethylamino)ethyl)(methyl)amino)-4-met...)
Show SMILES COc1cc(N(C)CCN(C)C)c(NC(=O)C=C)cc1Nc1nccc(n1)-c1cnc2n(C)ncc2c1
Show InChI InChI=1S/C26H31N9O2/c1-7-24(36)30-20-13-21(23(37-6)14-22(20)34(4)11-10-33(2)3)32-26-27-9-8-19(31-26)17-12-18-16-29-35(5)25(18)28-15-17/h7-9,12-16H,1,10-11H2,2-6H3,(H,30,36)(H,27,31,32)
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n/an/a 10n/an/an/an/an/an/a



SHANGHAI HAIYAN PHARMACEUTICAL TECHNOLOGY CO. LTD.

US Patent


Assay Description
The inhibitory effects of compounds to be tested on double mutant EGFR kinase (EGFR T790M/L858R Kinase) (Invitrogen, PV4879) and wild-type EGFR kinas...


US Patent US10435400 (2019)


BindingDB Entry DOI: 10.7270/Q20V8G4V
More data for this
Ligand-Target Pair
Epidermal growth factor receptor(L858R, T790M)


(Homo sapiens (Human))
BDBM414560
PNG
(US10435400, Compound Z-100)
Show SMILES COc1cc(N2CCN(C)CC2)c(NC(=O)C=C)cc1Nc1ncc(Cl)c(n1)-c1cnn(C)c1
Show InChI InChI=1S/C23H27ClN8O2/c1-5-21(33)27-17-10-18(20(34-4)11-19(17)32-8-6-30(2)7-9-32)28-23-25-13-16(24)22(29-23)15-12-26-31(3)14-15/h5,10-14H,1,6-9H2,2-4H3,(H,27,33)(H,25,28,29)
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n/an/a 11n/an/an/an/an/an/a



SHANGHAI HAIYAN PHARMACEUTICAL TECHNOLOGY CO. LTD.

US Patent


Assay Description
The inhibitory effects of compounds to be tested on double mutant EGFR kinase (EGFR T790M/L858R Kinase) (Invitrogen, PV4879) and wild-type EGFR kinas...


US Patent US10435400 (2019)


BindingDB Entry DOI: 10.7270/Q20V8G4V
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM414520
PNG
(N-(5-(5-chloro-4-(1-methyl-1H-pyrrolo[2,3-b]pyridi...)
Show SMILES COc1cc(N(C)CCN(C)C)c(NC(=O)C=C)cc1Nc1ncc(Cl)c(n1)-c1cnc2n(C)ccc2c1
Show InChI InChI=1S/C27H31ClN8O2/c1-7-24(37)31-20-13-21(23(38-6)14-22(20)35(4)11-10-34(2)3)32-27-30-16-19(28)25(33-27)18-12-17-8-9-36(5)26(17)29-15-18/h7-9,12-16H,1,10-11H2,2-6H3,(H,31,37)(H,30,32,33)
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n/an/a 11n/an/an/an/an/an/a



SHANGHAI HAIYAN PHARMACEUTICAL TECHNOLOGY CO. LTD.

US Patent


Assay Description
The inhibitory effects of compounds to be tested on double mutant EGFR kinase (EGFR T790M/L858R Kinase) (Invitrogen, PV4879) and wild-type EGFR kinas...


US Patent US10435400 (2019)


BindingDB Entry DOI: 10.7270/Q20V8G4V
More data for this
Ligand-Target Pair
Epidermal growth factor receptor(L858R, T790M)


(Homo sapiens (Human))
BDBM414552
PNG
(US10435400, Compound Z-93)
Show SMILES COc1cc(N(C)CCN(C)C)c(NC(=O)C=C)cc1Nc1ncc(F)c(n1)-c1cnn(C)c1
Show InChI InChI=1S/C23H29FN8O2/c1-7-21(33)27-17-10-18(20(34-6)11-19(17)31(4)9-8-30(2)3)28-23-25-13-16(24)22(29-23)15-12-26-32(5)14-15/h7,10-14H,1,8-9H2,2-6H3,(H,27,33)(H,25,28,29)
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n/an/a 11n/an/an/an/an/an/a



SHANGHAI HAIYAN PHARMACEUTICAL TECHNOLOGY CO. LTD.

US Patent


Assay Description
The inhibitory effects of compounds to be tested on double mutant EGFR kinase (EGFR T790M/L858R Kinase) (Invitrogen, PV4879) and wild-type EGFR kinas...


US Patent US10435400 (2019)


BindingDB Entry DOI: 10.7270/Q20V8G4V
More data for this
Ligand-Target Pair
Epidermal growth factor receptor(L858R, T790M)


(Homo sapiens (Human))
BDBM414522
PNG
(N-(2-(4-(dimethylamino)piperidin-1-yl)-4-methoxy-5...)
Show SMILES COc1cc(N2CCC(CC2)N(C)C)c(NC(=O)C=C)cc1Nc1nccc(n1)-c1cnc2n(C)ccc2c1
Show InChI InChI=1S/C29H34N8O2/c1-6-27(38)32-23-16-24(26(39-5)17-25(23)37-13-9-21(10-14-37)35(2)3)34-29-30-11-7-22(33-29)20-15-19-8-12-36(4)28(19)31-18-20/h6-8,11-12,15-18,21H,1,9-10,13-14H2,2-5H3,(H,32,38)(H,30,33,34)
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n/an/a 12n/an/an/an/an/an/a



SHANGHAI HAIYAN PHARMACEUTICAL TECHNOLOGY CO. LTD.

US Patent


Assay Description
The inhibitory effects of compounds to be tested on double mutant EGFR kinase (EGFR T790M/L858R Kinase) (Invitrogen, PV4879) and wild-type EGFR kinas...


US Patent US10435400 (2019)


BindingDB Entry DOI: 10.7270/Q20V8G4V
More data for this
Ligand-Target Pair
Epidermal growth factor receptor(L858R, T790M)


(Homo sapiens (Human))
BDBM414538
PNG
(US10435400, Compound Z-40)
Show SMILES COc1cc(N2CCC(CC2)N(C)C)c(NC(=O)C=C)cc1Nc1ncc(Cl)c(n1)-c1cnc2n(C)ncc2c1
Show InChI InChI=1S/C28H32ClN9O2/c1-6-25(39)33-21-12-22(24(40-5)13-23(21)38-9-7-19(8-10-38)36(2)3)34-28-31-16-20(29)26(35-28)17-11-18-15-32-37(4)27(18)30-14-17/h6,11-16,19H,1,7-10H2,2-5H3,(H,33,39)(H,31,34,35)
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n/an/a 13n/an/an/an/an/an/a



SHANGHAI HAIYAN PHARMACEUTICAL TECHNOLOGY CO. LTD.

US Patent


Assay Description
The inhibitory effects of compounds to be tested on double mutant EGFR kinase (EGFR T790M/L858R Kinase) (Invitrogen, PV4879) and wild-type EGFR kinas...


US Patent US10435400 (2019)


BindingDB Entry DOI: 10.7270/Q20V8G4V
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM414578
PNG
(US10435400, Compound Z-124)
Show SMILES COc1cc(N(C)CCN(C)C)c(NC(=O)C=C)cc1Nc1nccc(n1)-c1cnc2n(ccc2c1)C(C)C
Show InChI InChI=1S/C29H36N8O2/c1-8-27(38)32-23-16-24(26(39-7)17-25(23)36(6)14-13-35(4)5)34-29-30-11-9-22(33-29)21-15-20-10-12-37(19(2)3)28(20)31-18-21/h8-12,15-19H,1,13-14H2,2-7H3,(H,32,38)(H,30,33,34)
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n/an/a 13n/an/an/an/an/an/a



SHANGHAI HAIYAN PHARMACEUTICAL TECHNOLOGY CO. LTD.

US Patent


Assay Description
The inhibitory effects of compounds to be tested on double mutant EGFR kinase (EGFR T790M/L858R Kinase) (Invitrogen, PV4879) and wild-type EGFR kinas...


US Patent US10435400 (2019)


BindingDB Entry DOI: 10.7270/Q20V8G4V
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM414579
PNG
(US10435400, Compound Z-125)
Show SMILES COc1cc(N(C)CCN(C)C)c(NC(=O)C=C)cc1Nc1ncc(Cl)c(n1)-c1cnc2n(ccc2c1)C(C)C
Show InChI InChI=1S/C29H35ClN8O2/c1-8-26(39)33-22-14-23(25(40-7)15-24(22)37(6)12-11-36(4)5)34-29-32-17-21(30)27(35-29)20-13-19-9-10-38(18(2)3)28(19)31-16-20/h8-10,13-18H,1,11-12H2,2-7H3,(H,33,39)(H,32,34,35)
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SHANGHAI HAIYAN PHARMACEUTICAL TECHNOLOGY CO. LTD.

US Patent


Assay Description
The inhibitory effects of compounds to be tested on double mutant EGFR kinase (EGFR T790M/L858R Kinase) (Invitrogen, PV4879) and wild-type EGFR kinas...


US Patent US10435400 (2019)


BindingDB Entry DOI: 10.7270/Q20V8G4V
More data for this
Ligand-Target Pair
Epidermal growth factor receptor(L858R, T790M)


(Homo sapiens (Human))
BDBM414557
PNG
(US10435400, Compound Z-97)
Show SMILES COc1cc(N2CCC(CC2)N(C)C)c(NC(=O)C=C)cc1Nc1ncc(Cl)c(n1)-c1cnn(C)c1C
Show InChI InChI=1S/C26H33ClN8O2/c1-7-24(36)30-20-12-21(23(37-6)13-22(20)35-10-8-17(9-11-35)33(3)4)31-26-28-15-19(27)25(32-26)18-14-29-34(5)16(18)2/h7,12-15,17H,1,8-11H2,2-6H3,(H,30,36)(H,28,31,32)
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SHANGHAI HAIYAN PHARMACEUTICAL TECHNOLOGY CO. LTD.

US Patent


Assay Description
The inhibitory effects of compounds to be tested on double mutant EGFR kinase (EGFR T790M/L858R Kinase) (Invitrogen, PV4879) and wild-type EGFR kinas...


US Patent US10435400 (2019)


BindingDB Entry DOI: 10.7270/Q20V8G4V
More data for this
Ligand-Target Pair
Epidermal growth factor receptor(L858R, T790M)


(Homo sapiens (Human))
BDBM414522
PNG
(N-(2-(4-(dimethylamino)piperidin-1-yl)-4-methoxy-5...)
Show SMILES COc1cc(N2CCC(CC2)N(C)C)c(NC(=O)C=C)cc1Nc1nccc(n1)-c1cnc2n(C)ccc2c1
Show InChI InChI=1S/C29H34N8O2/c1-6-27(38)32-23-16-24(26(39-5)17-25(23)37-13-9-21(10-14-37)35(2)3)34-29-30-11-7-22(33-29)20-15-19-8-12-36(4)28(19)31-18-20/h6-8,11-12,15-18,21H,1,9-10,13-14H2,2-5H3,(H,32,38)(H,30,33,34)
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SHANGHAI HAIYAN PHARMACEUTICAL TECHNOLOGY CO. LTD.

US Patent


Assay Description
The inhibitory effects of compounds to be tested on double mutant EGFR kinase (EGFR T790M/L858R Kinase) (Invitrogen, PV4879) and wild-type EGFR kinas...


US Patent US10435400 (2019)


BindingDB Entry DOI: 10.7270/Q20V8G4V
More data for this
Ligand-Target Pair
Epidermal growth factor receptor(L858R, T790M)


(Homo sapiens (Human))
BDBM414570
PNG
(US10435400, Compound Z-114)
Show SMILES COc1cc(N(C)CCCN(C)C)c(NC(=O)C=C)cc1Nc1ncc(Cl)c(n1)-c1cnc2n(C)ccc2c1
Show InChI InChI=1S/C28H33ClN8O2/c1-7-25(38)32-21-14-22(24(39-6)15-23(21)36(4)11-8-10-35(2)3)33-28-31-17-20(29)26(34-28)19-13-18-9-12-37(5)27(18)30-16-19/h7,9,12-17H,1,8,10-11H2,2-6H3,(H,32,38)(H,31,33,34)
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SHANGHAI HAIYAN PHARMACEUTICAL TECHNOLOGY CO. LTD.

US Patent


Assay Description
The inhibitory effects of compounds to be tested on double mutant EGFR kinase (EGFR T790M/L858R Kinase) (Invitrogen, PV4879) and wild-type EGFR kinas...


US Patent US10435400 (2019)


BindingDB Entry DOI: 10.7270/Q20V8G4V
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM414575
PNG
(US10435400, Compound Z-121)
Show SMILES COc1cc(N(C)CCN(C)C)c(NC(=O)C=C)cc1Nc1ncc(Cl)c(n1)-c1cnc2n(C)cc(Cl)c2c1
Show InChI InChI=1S/C27H30Cl2N8O2/c1-7-24(38)32-20-11-21(23(39-6)12-22(20)36(4)9-8-35(2)3)33-27-31-14-18(28)25(34-27)16-10-17-19(29)15-37(5)26(17)30-13-16/h7,10-15H,1,8-9H2,2-6H3,(H,32,38)(H,31,33,34)
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SHANGHAI HAIYAN PHARMACEUTICAL TECHNOLOGY CO. LTD.

US Patent


Assay Description
The inhibitory effects of compounds to be tested on double mutant EGFR kinase (EGFR T790M/L858R Kinase) (Invitrogen, PV4879) and wild-type EGFR kinas...


US Patent US10435400 (2019)


BindingDB Entry DOI: 10.7270/Q20V8G4V
More data for this
Ligand-Target Pair
Epidermal growth factor receptor(L858R, T790M)


(Homo sapiens (Human))
BDBM414558
PNG
(US10435400, Compound Z-98)
Show SMILES COc1cc(N2CCC(CC2)N(C)C)c(NC(=O)C=C)cc1Nc1ncc(Cl)c(n1)-c1ccn(C)c1
Show InChI InChI=1S/C26H32ClN7O2/c1-6-24(35)29-20-13-21(23(36-5)14-22(20)34-11-8-18(9-12-34)32(2)3)30-26-28-15-19(27)25(31-26)17-7-10-33(4)16-17/h6-7,10,13-16,18H,1,8-9,11-12H2,2-5H3,(H,29,35)(H,28,30,31)
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n/an/a 15n/an/an/an/an/an/a



SHANGHAI HAIYAN PHARMACEUTICAL TECHNOLOGY CO. LTD.

US Patent


Assay Description
The inhibitory effects of compounds to be tested on double mutant EGFR kinase (EGFR T790M/L858R Kinase) (Invitrogen, PV4879) and wild-type EGFR kinas...


US Patent US10435400 (2019)


BindingDB Entry DOI: 10.7270/Q20V8G4V
More data for this
Ligand-Target Pair
Epidermal growth factor receptor(L858R, T790M)


(Homo sapiens (Human))
BDBM414569
PNG
(US10435400, Compound Z-113)
Show SMILES COc1cc(N2CC(C2)N(C)C)c(NC(=O)C=C)cc1Nc1ncc(Cl)c(n1)-c1cnc2n(C)ccc2c1
Show InChI InChI=1S/C27H29ClN8O2/c1-6-24(37)31-20-10-21(23(38-5)11-22(20)36-14-18(15-36)34(2)3)32-27-30-13-19(28)25(33-27)17-9-16-7-8-35(4)26(16)29-12-17/h6-13,18H,1,14-15H2,2-5H3,(H,31,37)(H,30,32,33)
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SHANGHAI HAIYAN PHARMACEUTICAL TECHNOLOGY CO. LTD.

US Patent


Assay Description
The inhibitory effects of compounds to be tested on double mutant EGFR kinase (EGFR T790M/L858R Kinase) (Invitrogen, PV4879) and wild-type EGFR kinas...


US Patent US10435400 (2019)


BindingDB Entry DOI: 10.7270/Q20V8G4V
More data for this
Ligand-Target Pair
Epidermal growth factor receptor(L858R, T790M)


(Homo sapiens (Human))
BDBM414555
PNG
(US10435400, Compound Z-95)
Show SMILES COc1cc(N2CCC(CC2)N(C)C)c(NC(=O)C=C)cc1Nc1ncc(Cl)c(n1)-c1cn(C)nc1C
Show InChI InChI=1S/C26H33ClN8O2/c1-7-24(36)29-20-12-21(23(37-6)13-22(20)35-10-8-17(9-11-35)33(3)4)30-26-28-14-19(27)25(31-26)18-15-34(5)32-16(18)2/h7,12-15,17H,1,8-11H2,2-6H3,(H,29,36)(H,28,30,31)
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n/an/a 16n/an/an/an/an/an/a



SHANGHAI HAIYAN PHARMACEUTICAL TECHNOLOGY CO. LTD.

US Patent


Assay Description
The inhibitory effects of compounds to be tested on double mutant EGFR kinase (EGFR T790M/L858R Kinase) (Invitrogen, PV4879) and wild-type EGFR kinas...


US Patent US10435400 (2019)


BindingDB Entry DOI: 10.7270/Q20V8G4V
More data for this
Ligand-Target Pair
Epidermal growth factor receptor(L858R, T790M)


(Homo sapiens (Human))
BDBM414536
PNG
(US10435400, Compound Z-38)
Show SMILES COc1cc(N2CCC(CC2)N(C)C)c(NC(=O)C=C)cc1Nc1ncc(OC)c(n1)-c1cnc2n(C)ncc2c1
Show InChI InChI=1S/C29H35N9O3/c1-7-26(39)33-21-13-22(24(40-5)14-23(21)38-10-8-20(9-11-38)36(2)3)34-29-31-17-25(41-6)27(35-29)18-12-19-16-32-37(4)28(19)30-15-18/h7,12-17,20H,1,8-11H2,2-6H3,(H,33,39)(H,31,34,35)
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n/an/a 16n/an/an/an/an/an/a



SHANGHAI HAIYAN PHARMACEUTICAL TECHNOLOGY CO. LTD.

US Patent


Assay Description
The inhibitory effects of compounds to be tested on double mutant EGFR kinase (EGFR T790M/L858R Kinase) (Invitrogen, PV4879) and wild-type EGFR kinas...


US Patent US10435400 (2019)


BindingDB Entry DOI: 10.7270/Q20V8G4V
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM414565
PNG
(US10435400, Compound Z-107)
Show SMILES CCN(CC)CCN(C)c1cc(OC)c(Nc2nccc(n2)-c2cnc3n(C)ccc3c2)cc1NC(=O)C=C
Show InChI InChI=1S/C29H36N8O2/c1-7-27(38)32-23-17-24(26(39-6)18-25(23)35(4)14-15-37(8-2)9-3)34-29-30-12-10-22(33-29)21-16-20-11-13-36(5)28(20)31-19-21/h7,10-13,16-19H,1,8-9,14-15H2,2-6H3,(H,32,38)(H,30,33,34)
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n/an/a 16n/an/an/an/an/an/a



SHANGHAI HAIYAN PHARMACEUTICAL TECHNOLOGY CO. LTD.

US Patent


Assay Description
The inhibitory effects of compounds to be tested on double mutant EGFR kinase (EGFR T790M/L858R Kinase) (Invitrogen, PV4879) and wild-type EGFR kinas...


US Patent US10435400 (2019)


BindingDB Entry DOI: 10.7270/Q20V8G4V
More data for this
Ligand-Target Pair
Epidermal growth factor receptor(L858R, T790M)


(Homo sapiens (Human))
BDBM414546
PNG
(US10435400, Compound Z-18)
Show SMILES COc1cc(N(C)CCN(C)C)c(NC(=O)C=C)cc1Nc1nccc(n1)-c1cnn(C)c1
Show InChI InChI=1S/C23H30N8O2/c1-7-22(32)26-18-12-19(21(33-6)13-20(18)30(4)11-10-29(2)3)28-23-24-9-8-17(27-23)16-14-25-31(5)15-16/h7-9,12-15H,1,10-11H2,2-6H3,(H,26,32)(H,24,27,28)
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n/an/a 16n/an/an/an/an/an/a



SHANGHAI HAIYAN PHARMACEUTICAL TECHNOLOGY CO. LTD.

US Patent


Assay Description
The inhibitory effects of compounds to be tested on double mutant EGFR kinase (EGFR T790M/L858R Kinase) (Invitrogen, PV4879) and wild-type EGFR kinas...


US Patent US10435400 (2019)


BindingDB Entry DOI: 10.7270/Q20V8G4V
More data for this
Ligand-Target Pair
Epidermal growth factor receptor(L858R, T790M)


(Homo sapiens (Human))
BDBM414521
PNG
(N-(5-(5-chloro-4-(1-methyl-1H-pyrrolo[2,3-b]pyridi...)
Show SMILES COc1cc(N2CCC(CC2)N(C)C)c(NC(=O)C=C)cc1Nc1ncc(Cl)c(n1)-c1cnc2n(C)ccc2c1
Show InChI InChI=1S/C29H33ClN8O2/c1-6-26(39)33-22-14-23(25(40-5)15-24(22)38-11-8-20(9-12-38)36(2)3)34-29-32-17-21(30)27(35-29)19-13-18-7-10-37(4)28(18)31-16-19/h6-7,10,13-17,20H,1,8-9,11-12H2,2-5H3,(H,33,39)(H,32,34,35)
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n/an/a 17n/an/an/an/an/an/a



SHANGHAI HAIYAN PHARMACEUTICAL TECHNOLOGY CO. LTD.

US Patent


Assay Description
The inhibitory effects of compounds to be tested on double mutant EGFR kinase (EGFR T790M/L858R Kinase) (Invitrogen, PV4879) and wild-type EGFR kinas...


US Patent US10435400 (2019)


BindingDB Entry DOI: 10.7270/Q20V8G4V
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM414532
PNG
(US10435400, Compound Z-27)
Show SMILES COc1cc(N2CC(C2)N(C)C)c(NC(=O)C=C)cc1Nc1nccc(n1)-c1cnc2n(C)ccc2c1
Show InChI InChI=1S/C27H30N8O2/c1-6-25(36)30-21-12-22(24(37-5)13-23(21)35-15-19(16-35)33(2)3)32-27-28-9-7-20(31-27)18-11-17-8-10-34(4)26(17)29-14-18/h6-14,19H,1,15-16H2,2-5H3,(H,30,36)(H,28,31,32)
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n/an/a 19n/an/an/an/an/an/a



SHANGHAI HAIYAN PHARMACEUTICAL TECHNOLOGY CO. LTD.

US Patent


Assay Description
The inhibitory effects of compounds to be tested on double mutant EGFR kinase (EGFR T790M/L858R Kinase) (Invitrogen, PV4879) and wild-type EGFR kinas...


US Patent US10435400 (2019)


BindingDB Entry DOI: 10.7270/Q20V8G4V
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM414539
PNG
(US10435400, Compound Z-41)
Show SMILES COc1cc(N(C)CCN(C)C)c(NC(=O)C=C)cc1Nc1ncc(F)c(n1)-c1cnc2n(C)ncc2c1
Show InChI InChI=1S/C26H30FN9O2/c1-7-23(37)31-19-11-20(22(38-6)12-21(19)35(4)9-8-34(2)3)32-26-29-15-18(27)24(33-26)16-10-17-14-30-36(5)25(17)28-13-16/h7,10-15H,1,8-9H2,2-6H3,(H,31,37)(H,29,32,33)
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n/an/a 20n/an/an/an/an/an/a



SHANGHAI HAIYAN PHARMACEUTICAL TECHNOLOGY CO. LTD.

US Patent


Assay Description
The inhibitory effects of compounds to be tested on double mutant EGFR kinase (EGFR T790M/L858R Kinase) (Invitrogen, PV4879) and wild-type EGFR kinas...


US Patent US10435400 (2019)


BindingDB Entry DOI: 10.7270/Q20V8G4V
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM414553
PNG
(US10435400, Compound Z-94)
Show SMILES COc1cc(N(C)CCN(C)C)c(NC(=O)C=C)cc1Nc1ncc(Cl)c(n1)-c1cn(C)nc1C
Show InChI InChI=1S/C24H31ClN8O2/c1-8-22(34)27-18-11-19(21(35-7)12-20(18)32(5)10-9-31(3)4)28-24-26-13-17(25)23(29-24)16-14-33(6)30-15(16)2/h8,11-14H,1,9-10H2,2-7H3,(H,27,34)(H,26,28,29)
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n/an/a 20n/an/an/an/an/an/a



SHANGHAI HAIYAN PHARMACEUTICAL TECHNOLOGY CO. LTD.

US Patent


Assay Description
The inhibitory effects of compounds to be tested on double mutant EGFR kinase (EGFR T790M/L858R Kinase) (Invitrogen, PV4879) and wild-type EGFR kinas...


US Patent US10435400 (2019)


BindingDB Entry DOI: 10.7270/Q20V8G4V
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM414549
PNG
(US10435400, Compound Z-55)
Show SMILES COc1cc(N(C)CCN(C)C)c(NC(=O)C=C)cc1Nc1ncc(Cl)c(n1)-c1cnn(C)c1C
Show InChI InChI=1S/C24H31ClN8O2/c1-8-22(34)28-18-11-19(21(35-7)12-20(18)32(5)10-9-31(3)4)29-24-26-14-17(25)23(30-24)16-13-27-33(6)15(16)2/h8,11-14H,1,9-10H2,2-7H3,(H,28,34)(H,26,29,30)
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n/an/a 21n/an/an/an/an/an/a



SHANGHAI HAIYAN PHARMACEUTICAL TECHNOLOGY CO. LTD.

US Patent


Assay Description
The inhibitory effects of compounds to be tested on double mutant EGFR kinase (EGFR T790M/L858R Kinase) (Invitrogen, PV4879) and wild-type EGFR kinas...


US Patent US10435400 (2019)


BindingDB Entry DOI: 10.7270/Q20V8G4V
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM414571
PNG
(US10435400, Compound Z-115)
Show SMILES COc1cc(N(C)CCN(C)C(C)C)c(NC(=O)C=C)cc1Nc1nccc(n1)-c1cnc2n(C)ccc2c1
Show InChI InChI=1S/C29H36N8O2/c1-8-27(38)32-23-16-24(26(39-7)17-25(23)36(5)14-13-35(4)19(2)3)34-29-30-11-9-22(33-29)21-15-20-10-12-37(6)28(20)31-18-21/h8-12,15-19H,1,13-14H2,2-7H3,(H,32,38)(H,30,33,34)
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n/an/a 22n/an/an/an/an/an/a



SHANGHAI HAIYAN PHARMACEUTICAL TECHNOLOGY CO. LTD.

US Patent


Assay Description
The inhibitory effects of compounds to be tested on double mutant EGFR kinase (EGFR T790M/L858R Kinase) (Invitrogen, PV4879) and wild-type EGFR kinas...


US Patent US10435400 (2019)


BindingDB Entry DOI: 10.7270/Q20V8G4V
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM414568
PNG
(US10435400, Compound Z-112)
Show SMILES COc1cc(N(C)CCN2CCCC2)c(NC(=O)C=C)cc1Nc1nccc(n1)-c1cnc2n(C)ccc2c1
Show InChI InChI=1S/C29H34N8O2/c1-5-27(38)32-23-17-24(26(39-4)18-25(23)35(2)14-15-37-11-6-7-12-37)34-29-30-10-8-22(33-29)21-16-20-9-13-36(3)28(20)31-19-21/h5,8-10,13,16-19H,1,6-7,11-12,14-15H2,2-4H3,(H,32,38)(H,30,33,34)
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SHANGHAI HAIYAN PHARMACEUTICAL TECHNOLOGY CO. LTD.

US Patent


Assay Description
The inhibitory effects of compounds to be tested on double mutant EGFR kinase (EGFR T790M/L858R Kinase) (Invitrogen, PV4879) and wild-type EGFR kinas...


US Patent US10435400 (2019)


BindingDB Entry DOI: 10.7270/Q20V8G4V
More data for this
Ligand-Target Pair
Epidermal growth factor receptor(L858R, T790M)


(Homo sapiens (Human))
BDBM414545
PNG
(US10435400, Compound Z-17)
Show SMILES COc1cc(N2CCC(CC2)N(C)C)c(NC(=O)C=C)cc1Nc1nccc(n1)-c1cnn(C)c1
Show InChI InChI=1S/C25H32N8O2/c1-6-24(34)28-20-13-21(30-25-26-10-7-19(29-25)17-15-27-32(4)16-17)23(35-5)14-22(20)33-11-8-18(9-12-33)31(2)3/h6-7,10,13-16,18H,1,8-9,11-12H2,2-5H3,(H,28,34)(H,26,29,30)
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n/an/a 23n/an/an/an/an/an/a



SHANGHAI HAIYAN PHARMACEUTICAL TECHNOLOGY CO. LTD.

US Patent


Assay Description
The inhibitory effects of compounds to be tested on double mutant EGFR kinase (EGFR T790M/L858R Kinase) (Invitrogen, PV4879) and wild-type EGFR kinas...


US Patent US10435400 (2019)


BindingDB Entry DOI: 10.7270/Q20V8G4V
More data for this
Ligand-Target Pair
Epidermal growth factor receptor(L858R, T790M)


(Homo sapiens (Human))
BDBM414551
PNG
(US10435400, Compound Z-91)
Show SMILES COc1cc(N(C)CCN(C)C)c(NC(=O)C=C)cc1Nc1ncc(Cl)c(n1)-c1c(C)nn(C)c1C
Show InChI InChI=1S/C25H33ClN8O2/c1-9-22(35)28-18-12-19(21(36-8)13-20(18)33(6)11-10-32(4)5)29-25-27-14-17(26)24(30-25)23-15(2)31-34(7)16(23)3/h9,12-14H,1,10-11H2,2-8H3,(H,28,35)(H,27,29,30)
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n/an/a 25n/an/an/an/an/an/a



SHANGHAI HAIYAN PHARMACEUTICAL TECHNOLOGY CO. LTD.

US Patent


Assay Description
The inhibitory effects of compounds to be tested on double mutant EGFR kinase (EGFR T790M/L858R Kinase) (Invitrogen, PV4879) and wild-type EGFR kinas...


US Patent US10435400 (2019)


BindingDB Entry DOI: 10.7270/Q20V8G4V
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM414576
PNG
(US10435400, Compound Z-122)
Show SMILES COc1cc(N2CCC(CC2)N(C)C)c(NC(=O)C=C)cc1Nc1ncc(F)c(n1)-c1cnc2n(C)cc(Cl)c2c1
Show InChI InChI=1S/C29H32ClFN8O2/c1-6-26(40)34-22-12-23(25(41-5)13-24(22)39-9-7-18(8-10-39)37(2)3)35-29-33-15-21(31)27(36-29)17-11-19-20(30)16-38(4)28(19)32-14-17/h6,11-16,18H,1,7-10H2,2-5H3,(H,34,40)(H,33,35,36)
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SHANGHAI HAIYAN PHARMACEUTICAL TECHNOLOGY CO. LTD.

US Patent


Assay Description
The inhibitory effects of compounds to be tested on double mutant EGFR kinase (EGFR T790M/L858R Kinase) (Invitrogen, PV4879) and wild-type EGFR kinas...


US Patent US10435400 (2019)


BindingDB Entry DOI: 10.7270/Q20V8G4V
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM414520
PNG
(N-(5-(5-chloro-4-(1-methyl-1H-pyrrolo[2,3-b]pyridi...)
Show SMILES COc1cc(N(C)CCN(C)C)c(NC(=O)C=C)cc1Nc1ncc(Cl)c(n1)-c1cnc2n(C)ccc2c1
Show InChI InChI=1S/C27H31ClN8O2/c1-7-24(37)31-20-13-21(23(38-6)14-22(20)35(4)11-10-34(2)3)32-27-30-16-19(28)25(33-27)18-12-17-8-9-36(5)26(17)29-15-18/h7-9,12-16H,1,10-11H2,2-6H3,(H,31,37)(H,30,32,33)
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SHANGHAI HAIYAN PHARMACEUTICAL TECHNOLOGY CO. LTD.

US Patent


Assay Description
The inhibitory effects of compounds to be tested on double mutant EGFR kinase (EGFR T790M/L858R Kinase) (Invitrogen, PV4879) and wild-type EGFR kinas...


US Patent US10435400 (2019)


BindingDB Entry DOI: 10.7270/Q20V8G4V
More data for this
Ligand-Target Pair
Epidermal growth factor receptor(L858R, T790M)


(Homo sapiens (Human))
BDBM414531
PNG
(US10435400, Compound Z-26)
Show SMILES COc1cc(N2CCN(C)CC2)c(NC(=O)C=C)cc1Nc1nccc(n1)-c1cnc2n(C)ccc2c1
Show InChI InChI=1S/C27H30N8O2/c1-5-25(36)30-21-15-22(24(37-4)16-23(21)35-12-10-33(2)11-13-35)32-27-28-8-6-20(31-27)19-14-18-7-9-34(3)26(18)29-17-19/h5-9,14-17H,1,10-13H2,2-4H3,(H,30,36)(H,28,31,32)
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n/an/a 27n/an/an/an/an/an/a



SHANGHAI HAIYAN PHARMACEUTICAL TECHNOLOGY CO. LTD.

US Patent


Assay Description
The inhibitory effects of compounds to be tested on double mutant EGFR kinase (EGFR T790M/L858R Kinase) (Invitrogen, PV4879) and wild-type EGFR kinas...


US Patent US10435400 (2019)


BindingDB Entry DOI: 10.7270/Q20V8G4V
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM414566
PNG
(US10435400, Compound Z-109)
Show SMILES CCN(C)CCN(C)c1cc(OC)c(Nc2ncc(Cl)c(n2)-c2cnc3n(C)ccc3c2)cc1NC(=O)C=C
Show InChI InChI=1S/C28H33ClN8O2/c1-7-25(38)32-21-14-22(24(39-6)15-23(21)36(4)12-11-35(3)8-2)33-28-31-17-20(29)26(34-28)19-13-18-9-10-37(5)27(18)30-16-19/h7,9-10,13-17H,1,8,11-12H2,2-6H3,(H,32,38)(H,31,33,34)
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n/an/a 28n/an/an/an/an/an/a



SHANGHAI HAIYAN PHARMACEUTICAL TECHNOLOGY CO. LTD.

US Patent


Assay Description
The inhibitory effects of compounds to be tested on double mutant EGFR kinase (EGFR T790M/L858R Kinase) (Invitrogen, PV4879) and wild-type EGFR kinas...


US Patent US10435400 (2019)


BindingDB Entry DOI: 10.7270/Q20V8G4V
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM414547
PNG
(US10435400, Compound Z-19)
Show SMILES COc1cc(N(C)CCN(C)C)c(NC(=O)C=C)cc1Nc1ncc(Cl)c(n1)-c1cnn(C)c1
Show InChI InChI=1S/C23H29ClN8O2/c1-7-21(33)27-17-10-18(20(34-6)11-19(17)31(4)9-8-30(2)3)28-23-25-13-16(24)22(29-23)15-12-26-32(5)14-15/h7,10-14H,1,8-9H2,2-6H3,(H,27,33)(H,25,28,29)
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n/an/a 28n/an/an/an/an/an/a



SHANGHAI HAIYAN PHARMACEUTICAL TECHNOLOGY CO. LTD.

US Patent


Assay Description
The inhibitory effects of compounds to be tested on double mutant EGFR kinase (EGFR T790M/L858R Kinase) (Invitrogen, PV4879) and wild-type EGFR kinas...


US Patent US10435400 (2019)


BindingDB Entry DOI: 10.7270/Q20V8G4V
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM414540
PNG
(US10435400, Compound Z-44)
Show SMILES COc1cc(N(C)CCN(C)C)c(NC(=O)C=C)cc1Nc1ncc(OC)c(n1)-c1cnc2n(C)ncc2c1
Show InChI InChI=1S/C27H33N9O3/c1-8-24(37)31-19-12-20(22(38-6)13-21(19)35(4)10-9-34(2)3)32-27-29-16-23(39-7)25(33-27)17-11-18-15-30-36(5)26(18)28-14-17/h8,11-16H,1,9-10H2,2-7H3,(H,31,37)(H,29,32,33)
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n/an/a 30n/an/an/an/an/an/a



SHANGHAI HAIYAN PHARMACEUTICAL TECHNOLOGY CO. LTD.

US Patent


Assay Description
The inhibitory effects of compounds to be tested on double mutant EGFR kinase (EGFR T790M/L858R Kinase) (Invitrogen, PV4879) and wild-type EGFR kinas...


US Patent US10435400 (2019)


BindingDB Entry DOI: 10.7270/Q20V8G4V
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM414537
PNG
(US10435400, Compound Z-39)
Show SMILES COc1cc(N(C)CCN(C)C)c(NC(=O)C=C)cc1Nc1ncc(Cl)c(n1)-c1cnc2n(C)ncc2c1
Show InChI InChI=1S/C26H30ClN9O2/c1-7-23(37)31-19-11-20(22(38-6)12-21(19)35(4)9-8-34(2)3)32-26-29-15-18(27)24(33-26)16-10-17-14-30-36(5)25(17)28-13-16/h7,10-15H,1,8-9H2,2-6H3,(H,31,37)(H,29,32,33)
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n/an/a 33n/an/an/an/an/an/a



SHANGHAI HAIYAN PHARMACEUTICAL TECHNOLOGY CO. LTD.

US Patent


Assay Description
The inhibitory effects of compounds to be tested on double mutant EGFR kinase (EGFR T790M/L858R Kinase) (Invitrogen, PV4879) and wild-type EGFR kinas...


US Patent US10435400 (2019)


BindingDB Entry DOI: 10.7270/Q20V8G4V
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM414536
PNG
(US10435400, Compound Z-38)
Show SMILES COc1cc(N2CCC(CC2)N(C)C)c(NC(=O)C=C)cc1Nc1ncc(OC)c(n1)-c1cnc2n(C)ncc2c1
Show InChI InChI=1S/C29H35N9O3/c1-7-26(39)33-21-13-22(24(40-5)14-23(21)38-10-8-20(9-11-38)36(2)3)34-29-31-17-25(41-6)27(35-29)18-12-19-16-32-37(4)28(19)30-15-18/h7,12-17,20H,1,8-11H2,2-6H3,(H,33,39)(H,31,34,35)
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n/an/a 35n/an/an/an/an/an/a



SHANGHAI HAIYAN PHARMACEUTICAL TECHNOLOGY CO. LTD.

US Patent


Assay Description
The inhibitory effects of compounds to be tested on double mutant EGFR kinase (EGFR T790M/L858R Kinase) (Invitrogen, PV4879) and wild-type EGFR kinas...


US Patent US10435400 (2019)


BindingDB Entry DOI: 10.7270/Q20V8G4V
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM414572
PNG
(US10435400, Compound Z-116)
Show SMILES CNCCN(C)c1cc(OC)c(Nc2ncc(Cl)c(n2)-c2cnc3n(C)ccc3c2)cc1NC(=O)C=C
Show InChI InChI=1S/C26H29ClN8O2/c1-6-23(36)31-19-12-20(22(37-5)13-21(19)34(3)10-8-28-2)32-26-30-15-18(27)24(33-26)17-11-16-7-9-35(4)25(16)29-14-17/h6-7,9,11-15,28H,1,8,10H2,2-5H3,(H,31,36)(H,30,32,33)
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n/an/a 37n/an/an/an/an/an/a



SHANGHAI HAIYAN PHARMACEUTICAL TECHNOLOGY CO. LTD.

US Patent


Assay Description
The inhibitory effects of compounds to be tested on double mutant EGFR kinase (EGFR T790M/L858R Kinase) (Invitrogen, PV4879) and wild-type EGFR kinas...


US Patent US10435400 (2019)


BindingDB Entry DOI: 10.7270/Q20V8G4V
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM414559
PNG
(US10435400, Compound Z-99)
Show SMILES COc1cc(N(C)CCN(C)C)c(NC(=O)C=C)cc1Nc1ncc(Cl)c(n1)-c1ccn(C)c1
Show InChI InChI=1S/C24H30ClN7O2/c1-7-22(33)27-18-12-19(21(34-6)13-20(18)32(5)11-10-30(2)3)28-24-26-14-17(25)23(29-24)16-8-9-31(4)15-16/h7-9,12-15H,1,10-11H2,2-6H3,(H,27,33)(H,26,28,29)
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n/an/a 38n/an/an/an/an/an/a



SHANGHAI HAIYAN PHARMACEUTICAL TECHNOLOGY CO. LTD.

US Patent


Assay Description
The inhibitory effects of compounds to be tested on double mutant EGFR kinase (EGFR T790M/L858R Kinase) (Invitrogen, PV4879) and wild-type EGFR kinas...


US Patent US10435400 (2019)


BindingDB Entry DOI: 10.7270/Q20V8G4V
More data for this
Ligand-Target Pair
Epidermal growth factor receptor(L858R, T790M)


(Homo sapiens (Human))
BDBM414533
PNG
(US10435400, Compound Z-29)
Show SMILES COc1cc(N2CCC(CC2)N(C)C)c(NC(=O)C=C)cc1Nc1ncc(F)c(n1)-c1cnc2n(C)ccc2c1
Show InChI InChI=1S/C29H33FN8O2/c1-6-26(39)33-22-14-23(25(40-5)15-24(22)38-11-8-20(9-12-38)36(2)3)34-29-32-17-21(30)27(35-29)19-13-18-7-10-37(4)28(18)31-16-19/h6-7,10,13-17,20H,1,8-9,11-12H2,2-5H3,(H,33,39)(H,32,34,35)
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n/an/a 38n/an/an/an/an/an/a



SHANGHAI HAIYAN PHARMACEUTICAL TECHNOLOGY CO. LTD.

US Patent


Assay Description
The inhibitory effects of compounds to be tested on double mutant EGFR kinase (EGFR T790M/L858R Kinase) (Invitrogen, PV4879) and wild-type EGFR kinas...


US Patent US10435400 (2019)


BindingDB Entry DOI: 10.7270/Q20V8G4V
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM414567
PNG
(US10435400, Compound Z-110)
Show SMILES CCN(CC)CCN(C)c1cc(OC)c(Nc2ncc(Cl)c(n2)-c2cnc3n(C)ccc3c2)cc1NC(=O)C=C
Show InChI InChI=1S/C29H35ClN8O2/c1-7-26(39)33-22-15-23(25(40-6)16-24(22)36(4)12-13-38(8-2)9-3)34-29-32-18-21(30)27(35-29)20-14-19-10-11-37(5)28(19)31-17-20/h7,10-11,14-18H,1,8-9,12-13H2,2-6H3,(H,33,39)(H,32,34,35)
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n/an/a 40n/an/an/an/an/an/a



SHANGHAI HAIYAN PHARMACEUTICAL TECHNOLOGY CO. LTD.

US Patent


Assay Description
The inhibitory effects of compounds to be tested on double mutant EGFR kinase (EGFR T790M/L858R Kinase) (Invitrogen, PV4879) and wild-type EGFR kinas...


US Patent US10435400 (2019)


BindingDB Entry DOI: 10.7270/Q20V8G4V
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM414556
PNG
(US10435400, Compound Z-96)
Show SMILES COc1cc(N2CCC(CC2)N(C)C)c(NC(=O)C=C)cc1Nc1ncc(Cl)c(n1)-c1cnn(c1)C1CCN(CC1)C(=O)OC(C)(C)C
Show InChI InChI=1S/C34H46ClN9O4/c1-8-30(45)38-26-17-27(29(47-7)18-28(26)42-13-9-23(10-14-42)41(5)6)39-32-36-20-25(35)31(40-32)22-19-37-44(21-22)24-11-15-43(16-12-24)33(46)48-34(2,3)4/h8,17-21,23-24H,1,9-16H2,2-7H3,(H,38,45)(H,36,39,40)
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n/an/a 41n/an/an/an/an/an/a



SHANGHAI HAIYAN PHARMACEUTICAL TECHNOLOGY CO. LTD.

US Patent


Assay Description
The inhibitory effects of compounds to be tested on double mutant EGFR kinase (EGFR T790M/L858R Kinase) (Invitrogen, PV4879) and wild-type EGFR kinas...


US Patent US10435400 (2019)


BindingDB Entry DOI: 10.7270/Q20V8G4V
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM414552
PNG
(US10435400, Compound Z-93)
Show SMILES COc1cc(N(C)CCN(C)C)c(NC(=O)C=C)cc1Nc1ncc(F)c(n1)-c1cnn(C)c1
Show InChI InChI=1S/C23H29FN8O2/c1-7-21(33)27-17-10-18(20(34-6)11-19(17)31(4)9-8-30(2)3)28-23-25-13-16(24)22(29-23)15-12-26-32(5)14-15/h7,10-14H,1,8-9H2,2-6H3,(H,27,33)(H,25,28,29)
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n/an/a 42n/an/an/an/an/an/a



SHANGHAI HAIYAN PHARMACEUTICAL TECHNOLOGY CO. LTD.

US Patent


Assay Description
The inhibitory effects of compounds to be tested on double mutant EGFR kinase (EGFR T790M/L858R Kinase) (Invitrogen, PV4879) and wild-type EGFR kinas...


US Patent US10435400 (2019)


BindingDB Entry DOI: 10.7270/Q20V8G4V
More data for this
Ligand-Target Pair
Epidermal growth factor receptor(L858R, T790M)


(Homo sapiens (Human))
BDBM414523
PNG
(N-(4-methoxy-5-(4-(1-methyl-1H-pyrazolo[3,4-b]pyri...)
Show SMILES COc1cc(N2CCN(C)CC2)c(NC(=O)C=C)cc1Nc1nccc(n1)-c1cnc2n(C)ncc2c1
Show InChI InChI=1S/C26H29N9O2/c1-5-24(36)30-20-13-21(23(37-4)14-22(20)35-10-8-33(2)9-11-35)32-26-27-7-6-19(31-26)17-12-18-16-29-34(3)25(18)28-15-17/h5-7,12-16H,1,8-11H2,2-4H3,(H,30,36)(H,27,31,32)
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n/an/a 43n/an/an/an/an/an/a



SHANGHAI HAIYAN PHARMACEUTICAL TECHNOLOGY CO. LTD.

US Patent


Assay Description
The inhibitory effects of compounds to be tested on double mutant EGFR kinase (EGFR T790M/L858R Kinase) (Invitrogen, PV4879) and wild-type EGFR kinas...


US Patent US10435400 (2019)


BindingDB Entry DOI: 10.7270/Q20V8G4V
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM414522
PNG
(N-(2-(4-(dimethylamino)piperidin-1-yl)-4-methoxy-5...)
Show SMILES COc1cc(N2CCC(CC2)N(C)C)c(NC(=O)C=C)cc1Nc1nccc(n1)-c1cnc2n(C)ccc2c1
Show InChI InChI=1S/C29H34N8O2/c1-6-27(38)32-23-16-24(26(39-5)17-25(23)37-13-9-21(10-14-37)35(2)3)34-29-30-11-7-22(33-29)20-15-19-8-12-36(4)28(19)31-18-20/h6-8,11-12,15-18,21H,1,9-10,13-14H2,2-5H3,(H,32,38)(H,30,33,34)
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n/an/a 45n/an/an/an/an/an/a



SHANGHAI HAIYAN PHARMACEUTICAL TECHNOLOGY CO. LTD.

US Patent


Assay Description
The inhibitory effects of compounds to be tested on double mutant EGFR kinase (EGFR T790M/L858R Kinase) (Invitrogen, PV4879) and wild-type EGFR kinas...


US Patent US10435400 (2019)


BindingDB Entry DOI: 10.7270/Q20V8G4V
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM414529
PNG
(N-(2-((2-(dimethylamino)ethyl)(methyl)amino)-4-met...)
Show SMILES COc1cc(N(C)CCN(C)C)c(NC(=O)C=C)cc1Nc1ncc(c(n1)-c1cnc2n(C)ccc2c1)C(F)(F)F
Show InChI InChI=1S/C28H31F3N8O2/c1-7-24(40)34-20-13-21(23(41-6)14-22(20)38(4)11-10-37(2)3)35-27-33-16-19(28(29,30)31)25(36-27)18-12-17-8-9-39(5)26(17)32-15-18/h7-9,12-16H,1,10-11H2,2-6H3,(H,34,40)(H,33,35,36)
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n/an/a 57n/an/an/an/an/an/a



SHANGHAI HAIYAN PHARMACEUTICAL TECHNOLOGY CO. LTD.

US Patent


Assay Description
The inhibitory effects of compounds to be tested on double mutant EGFR kinase (EGFR T790M/L858R Kinase) (Invitrogen, PV4879) and wild-type EGFR kinas...


US Patent US10435400 (2019)


BindingDB Entry DOI: 10.7270/Q20V8G4V
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM414522
PNG
(N-(2-(4-(dimethylamino)piperidin-1-yl)-4-methoxy-5...)
Show SMILES COc1cc(N2CCC(CC2)N(C)C)c(NC(=O)C=C)cc1Nc1nccc(n1)-c1cnc2n(C)ccc2c1
Show InChI InChI=1S/C29H34N8O2/c1-6-27(38)32-23-16-24(26(39-5)17-25(23)37-13-9-21(10-14-37)35(2)3)34-29-30-11-7-22(33-29)20-15-19-8-12-36(4)28(19)31-18-20/h6-8,11-12,15-18,21H,1,9-10,13-14H2,2-5H3,(H,32,38)(H,30,33,34)
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n/an/a 61n/an/an/an/an/an/a



SHANGHAI HAIYAN PHARMACEUTICAL TECHNOLOGY CO. LTD.

US Patent


Assay Description
The inhibitory effects of compounds to be tested on double mutant EGFR kinase (EGFR T790M/L858R Kinase) (Invitrogen, PV4879) and wild-type EGFR kinas...


US Patent US10435400 (2019)


BindingDB Entry DOI: 10.7270/Q20V8G4V
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM414562
PNG
(US10435400, Compound Z-102)
Show SMILES COc1cc(N2CCC(CC2)N(C)C)c(NC(=O)C=C)cc1Nc1ncc(Cl)c(n1)-c1cn[nH]c1
Show InChI InChI=1S/C24H29ClN8O2/c1-5-22(34)29-18-10-19(30-24-26-14-17(25)23(31-24)15-12-27-28-13-15)21(35-4)11-20(18)33-8-6-16(7-9-33)32(2)3/h5,10-14,16H,1,6-9H2,2-4H3,(H,27,28)(H,29,34)(H,26,30,31)
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n/an/a 62n/an/an/an/an/an/a



SHANGHAI HAIYAN PHARMACEUTICAL TECHNOLOGY CO. LTD.

US Patent


Assay Description
The inhibitory effects of compounds to be tested on double mutant EGFR kinase (EGFR T790M/L858R Kinase) (Invitrogen, PV4879) and wild-type EGFR kinas...


US Patent US10435400 (2019)


BindingDB Entry DOI: 10.7270/Q20V8G4V
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM414535
PNG
(US10435400, Compound Z-37)
Show SMILES COc1cc(N2CCC(CC2)N(C)C)c(NC(=O)C=C)cc1Nc1ncc(F)c(n1)-c1cnc2n(C)ncc2c1
Show InChI InChI=1S/C28H32FN9O2/c1-6-25(39)33-21-12-22(24(40-5)13-23(21)38-9-7-19(8-10-38)36(2)3)34-28-31-16-20(29)26(35-28)17-11-18-15-32-37(4)27(18)30-14-17/h6,11-16,19H,1,7-10H2,2-5H3,(H,33,39)(H,31,34,35)
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n/an/a 89n/an/an/an/an/an/a



SHANGHAI HAIYAN PHARMACEUTICAL TECHNOLOGY CO. LTD.

US Patent


Assay Description
The inhibitory effects of compounds to be tested on double mutant EGFR kinase (EGFR T790M/L858R Kinase) (Invitrogen, PV4879) and wild-type EGFR kinas...


US Patent US10435400 (2019)


BindingDB Entry DOI: 10.7270/Q20V8G4V
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM414550
PNG
(US10435400, Compound Z-90)
Show SMILES COc1cc(N2CCC(CC2)N(C)C)c(NC(=O)C=C)cc1Nc1ncc(F)c(n1)-c1cnn(C)c1
Show InChI InChI=1S/C25H31FN8O2/c1-6-23(35)29-19-11-20(22(36-5)12-21(19)34-9-7-17(8-10-34)32(2)3)30-25-27-14-18(26)24(31-25)16-13-28-33(4)15-16/h6,11-15,17H,1,7-10H2,2-5H3,(H,29,35)(H,27,30,31)
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n/an/a 102n/an/an/an/an/an/a



SHANGHAI HAIYAN PHARMACEUTICAL TECHNOLOGY CO. LTD.

US Patent


Assay Description
The inhibitory effects of compounds to be tested on double mutant EGFR kinase (EGFR T790M/L858R Kinase) (Invitrogen, PV4879) and wild-type EGFR kinas...


US Patent US10435400 (2019)


BindingDB Entry DOI: 10.7270/Q20V8G4V
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM414523
PNG
(N-(4-methoxy-5-(4-(1-methyl-1H-pyrazolo[3,4-b]pyri...)
Show SMILES COc1cc(N2CCN(C)CC2)c(NC(=O)C=C)cc1Nc1nccc(n1)-c1cnc2n(C)ncc2c1
Show InChI InChI=1S/C26H29N9O2/c1-5-24(36)30-20-13-21(23(37-4)14-22(20)35-10-8-33(2)9-11-35)32-26-27-7-6-19(31-26)17-12-18-16-29-34(3)25(18)28-15-17/h5-7,12-16H,1,8-11H2,2-4H3,(H,30,36)(H,27,31,32)
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n/an/a 105n/an/an/an/an/an/a



SHANGHAI HAIYAN PHARMACEUTICAL TECHNOLOGY CO. LTD.

US Patent


Assay Description
The inhibitory effects of compounds to be tested on double mutant EGFR kinase (EGFR T790M/L858R Kinase) (Invitrogen, PV4879) and wild-type EGFR kinas...


US Patent US10435400 (2019)


BindingDB Entry DOI: 10.7270/Q20V8G4V
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM414561
PNG
(US10435400, Compound Z-101)
Show SMILES COc1cc(N2CCC(CC2)N(C)C)c(NC(=O)C=C)cc1Nc1ncc(Cl)c(n1)-c1cnn(c1)C(F)F
Show InChI InChI=1S/C25H29ClF2N8O2/c1-5-22(37)31-18-10-19(21(38-4)11-20(18)35-8-6-16(7-9-35)34(2)3)32-25-29-13-17(26)23(33-25)15-12-30-36(14-15)24(27)28/h5,10-14,16,24H,1,6-9H2,2-4H3,(H,31,37)(H,29,32,33)
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n/an/a 112n/an/an/an/an/an/a



SHANGHAI HAIYAN PHARMACEUTICAL TECHNOLOGY CO. LTD.

US Patent


Assay Description
The inhibitory effects of compounds to be tested on double mutant EGFR kinase (EGFR T790M/L858R Kinase) (Invitrogen, PV4879) and wild-type EGFR kinas...


US Patent US10435400 (2019)


BindingDB Entry DOI: 10.7270/Q20V8G4V
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM414531
PNG
(US10435400, Compound Z-26)
Show SMILES COc1cc(N2CCN(C)CC2)c(NC(=O)C=C)cc1Nc1nccc(n1)-c1cnc2n(C)ccc2c1
Show InChI InChI=1S/C27H30N8O2/c1-5-25(36)30-21-15-22(24(37-4)16-23(21)35-12-10-33(2)11-13-35)32-27-28-8-6-20(31-27)19-14-18-7-9-34(3)26(18)29-17-19/h5-9,14-17H,1,10-13H2,2-4H3,(H,30,36)(H,28,31,32)
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n/an/a 114n/an/an/an/an/an/a



SHANGHAI HAIYAN PHARMACEUTICAL TECHNOLOGY CO. LTD.

US Patent


Assay Description
The inhibitory effects of compounds to be tested on double mutant EGFR kinase (EGFR T790M/L858R Kinase) (Invitrogen, PV4879) and wild-type EGFR kinas...


US Patent US10435400 (2019)


BindingDB Entry DOI: 10.7270/Q20V8G4V
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM414570
PNG
(US10435400, Compound Z-114)
Show SMILES COc1cc(N(C)CCCN(C)C)c(NC(=O)C=C)cc1Nc1ncc(Cl)c(n1)-c1cnc2n(C)ccc2c1
Show InChI InChI=1S/C28H33ClN8O2/c1-7-25(38)32-21-14-22(24(39-6)15-23(21)36(4)11-8-10-35(2)3)33-28-31-17-20(29)26(34-28)19-13-18-9-12-37(5)27(18)30-16-19/h7,9,12-17H,1,8,10-11H2,2-6H3,(H,32,38)(H,31,33,34)
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n/an/a 116n/an/an/an/an/an/a



SHANGHAI HAIYAN PHARMACEUTICAL TECHNOLOGY CO. LTD.

US Patent


Assay Description
The inhibitory effects of compounds to be tested on double mutant EGFR kinase (EGFR T790M/L858R Kinase) (Invitrogen, PV4879) and wild-type EGFR kinas...


US Patent US10435400 (2019)


BindingDB Entry DOI: 10.7270/Q20V8G4V
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM414533
PNG
(US10435400, Compound Z-29)
Show SMILES COc1cc(N2CCC(CC2)N(C)C)c(NC(=O)C=C)cc1Nc1ncc(F)c(n1)-c1cnc2n(C)ccc2c1
Show InChI InChI=1S/C29H33FN8O2/c1-6-26(39)33-22-14-23(25(40-5)15-24(22)38-11-8-20(9-12-38)36(2)3)34-29-32-17-21(30)27(35-29)19-13-18-7-10-37(4)28(18)31-16-19/h6-7,10,13-17,20H,1,8-9,11-12H2,2-5H3,(H,33,39)(H,32,34,35)
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n/an/a 118n/an/an/an/an/an/a



SHANGHAI HAIYAN PHARMACEUTICAL TECHNOLOGY CO. LTD.

US Patent


Assay Description
The inhibitory effects of compounds to be tested on double mutant EGFR kinase (EGFR T790M/L858R Kinase) (Invitrogen, PV4879) and wild-type EGFR kinas...


US Patent US10435400 (2019)


BindingDB Entry DOI: 10.7270/Q20V8G4V
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM414569
PNG
(US10435400, Compound Z-113)
Show SMILES COc1cc(N2CC(C2)N(C)C)c(NC(=O)C=C)cc1Nc1ncc(Cl)c(n1)-c1cnc2n(C)ccc2c1
Show InChI InChI=1S/C27H29ClN8O2/c1-6-24(37)31-20-10-21(23(38-5)11-22(20)36-14-18(15-36)34(2)3)32-27-30-13-19(28)25(33-27)17-9-16-7-8-35(4)26(16)29-12-17/h6-13,18H,1,14-15H2,2-5H3,(H,31,37)(H,30,32,33)
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n/an/a 121n/an/an/an/an/an/a



SHANGHAI HAIYAN PHARMACEUTICAL TECHNOLOGY CO. LTD.

US Patent


Assay Description
The inhibitory effects of compounds to be tested on double mutant EGFR kinase (EGFR T790M/L858R Kinase) (Invitrogen, PV4879) and wild-type EGFR kinas...


US Patent US10435400 (2019)


BindingDB Entry DOI: 10.7270/Q20V8G4V
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM414551
PNG
(US10435400, Compound Z-91)
Show SMILES COc1cc(N(C)CCN(C)C)c(NC(=O)C=C)cc1Nc1ncc(Cl)c(n1)-c1c(C)nn(C)c1C
Show InChI InChI=1S/C25H33ClN8O2/c1-9-22(35)28-18-12-19(21(36-8)13-20(18)33(6)11-10-32(4)5)29-25-27-14-17(26)24(30-25)23-15(2)31-34(7)16(23)3/h9,12-14H,1,10-11H2,2-8H3,(H,28,35)(H,27,29,30)
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n/an/a 195n/an/an/an/an/an/a



SHANGHAI HAIYAN PHARMACEUTICAL TECHNOLOGY CO. LTD.

US Patent


Assay Description
The inhibitory effects of compounds to be tested on double mutant EGFR kinase (EGFR T790M/L858R Kinase) (Invitrogen, PV4879) and wild-type EGFR kinas...


US Patent US10435400 (2019)


BindingDB Entry DOI: 10.7270/Q20V8G4V
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM414546
PNG
(US10435400, Compound Z-18)
Show SMILES COc1cc(N(C)CCN(C)C)c(NC(=O)C=C)cc1Nc1nccc(n1)-c1cnn(C)c1
Show InChI InChI=1S/C23H30N8O2/c1-7-22(32)26-18-12-19(21(33-6)13-20(18)30(4)11-10-29(2)3)28-23-24-9-8-17(27-23)16-14-25-31(5)15-16/h7-9,12-15H,1,10-11H2,2-6H3,(H,26,32)(H,24,27,28)
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n/an/a 197n/an/an/an/an/an/a



SHANGHAI HAIYAN PHARMACEUTICAL TECHNOLOGY CO. LTD.

US Patent


Assay Description
The inhibitory effects of compounds to be tested on double mutant EGFR kinase (EGFR T790M/L858R Kinase) (Invitrogen, PV4879) and wild-type EGFR kinas...


US Patent US10435400 (2019)


BindingDB Entry DOI: 10.7270/Q20V8G4V
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM414545
PNG
(US10435400, Compound Z-17)
Show SMILES COc1cc(N2CCC(CC2)N(C)C)c(NC(=O)C=C)cc1Nc1nccc(n1)-c1cnn(C)c1
Show InChI InChI=1S/C25H32N8O2/c1-6-24(34)28-20-13-21(30-25-26-10-7-19(29-25)17-15-27-32(4)16-17)23(35-5)14-22(20)33-11-8-18(9-12-33)31(2)3/h6-7,10,13-16,18H,1,8-9,11-12H2,2-5H3,(H,28,34)(H,26,29,30)
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n/an/a 218n/an/an/an/an/an/a



SHANGHAI HAIYAN PHARMACEUTICAL TECHNOLOGY CO. LTD.

US Patent


Assay Description
The inhibitory effects of compounds to be tested on double mutant EGFR kinase (EGFR T790M/L858R Kinase) (Invitrogen, PV4879) and wild-type EGFR kinas...


US Patent US10435400 (2019)


BindingDB Entry DOI: 10.7270/Q20V8G4V
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM414548
PNG
(US10435400, Compound Z-89)
Show SMILES COc1cc(N2CCC(CC2)N(C)C)c(NC(=O)C=C)cc1Nc1ncc(Cl)c(n1)-c1cnn(C)c1
Show InChI InChI=1S/C25H31ClN8O2/c1-6-23(35)29-19-11-20(22(36-5)12-21(19)34-9-7-17(8-10-34)32(2)3)30-25-27-14-18(26)24(31-25)16-13-28-33(4)15-16/h6,11-15,17H,1,7-10H2,2-5H3,(H,29,35)(H,27,30,31)
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n/an/a 228n/an/an/an/an/an/a



SHANGHAI HAIYAN PHARMACEUTICAL TECHNOLOGY CO. LTD.

US Patent


Assay Description
The inhibitory effects of compounds to be tested on double mutant EGFR kinase (EGFR T790M/L858R Kinase) (Invitrogen, PV4879) and wild-type EGFR kinas...


US Patent US10435400 (2019)


BindingDB Entry DOI: 10.7270/Q20V8G4V
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM414538
PNG
(US10435400, Compound Z-40)
Show SMILES COc1cc(N2CCC(CC2)N(C)C)c(NC(=O)C=C)cc1Nc1ncc(Cl)c(n1)-c1cnc2n(C)ncc2c1
Show InChI InChI=1S/C28H32ClN9O2/c1-6-25(39)33-21-12-22(24(40-5)13-23(21)38-9-7-19(8-10-38)36(2)3)34-28-31-16-20(29)26(35-28)17-11-18-15-32-37(4)27(18)30-14-17/h6,11-16,19H,1,7-10H2,2-5H3,(H,33,39)(H,31,34,35)
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n/an/a 233n/an/an/an/an/an/a



SHANGHAI HAIYAN PHARMACEUTICAL TECHNOLOGY CO. LTD.

US Patent


Assay Description
The inhibitory effects of compounds to be tested on double mutant EGFR kinase (EGFR T790M/L858R Kinase) (Invitrogen, PV4879) and wild-type EGFR kinas...


US Patent US10435400 (2019)


BindingDB Entry DOI: 10.7270/Q20V8G4V
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM414521
PNG
(N-(5-(5-chloro-4-(1-methyl-1H-pyrrolo[2,3-b]pyridi...)
Show SMILES COc1cc(N2CCC(CC2)N(C)C)c(NC(=O)C=C)cc1Nc1ncc(Cl)c(n1)-c1cnc2n(C)ccc2c1
Show InChI InChI=1S/C29H33ClN8O2/c1-6-26(39)33-22-14-23(25(40-5)15-24(22)38-11-8-20(9-12-38)36(2)3)34-29-32-17-21(30)27(35-29)19-13-18-7-10-37(4)28(18)31-16-19/h6-7,10,13-17,20H,1,8-9,11-12H2,2-5H3,(H,33,39)(H,32,34,35)
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n/an/a 272n/an/an/an/an/an/a



SHANGHAI HAIYAN PHARMACEUTICAL TECHNOLOGY CO. LTD.

US Patent


Assay Description
The inhibitory effects of compounds to be tested on double mutant EGFR kinase (EGFR T790M/L858R Kinase) (Invitrogen, PV4879) and wild-type EGFR kinas...


US Patent US10435400 (2019)


BindingDB Entry DOI: 10.7270/Q20V8G4V
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM414560
PNG
(US10435400, Compound Z-100)
Show SMILES COc1cc(N2CCN(C)CC2)c(NC(=O)C=C)cc1Nc1ncc(Cl)c(n1)-c1cnn(C)c1
Show InChI InChI=1S/C23H27ClN8O2/c1-5-21(33)27-17-10-18(20(34-4)11-19(17)32-8-6-30(2)7-9-32)28-23-25-13-16(24)22(29-23)15-12-26-31(3)14-15/h5,10-14H,1,6-9H2,2-4H3,(H,27,33)(H,25,28,29)
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n/an/a 297n/an/an/an/an/an/a



SHANGHAI HAIYAN PHARMACEUTICAL TECHNOLOGY CO. LTD.

US Patent


Assay Description
The inhibitory effects of compounds to be tested on double mutant EGFR kinase (EGFR T790M/L858R Kinase) (Invitrogen, PV4879) and wild-type EGFR kinas...


US Patent US10435400 (2019)


BindingDB Entry DOI: 10.7270/Q20V8G4V
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM414555
PNG
(US10435400, Compound Z-95)
Show SMILES COc1cc(N2CCC(CC2)N(C)C)c(NC(=O)C=C)cc1Nc1ncc(Cl)c(n1)-c1cn(C)nc1C
Show InChI InChI=1S/C26H33ClN8O2/c1-7-24(36)29-20-12-21(23(37-6)13-22(20)35-10-8-17(9-11-35)33(3)4)30-26-28-14-19(27)25(31-26)18-15-34(5)32-16(18)2/h7,12-15,17H,1,8-11H2,2-6H3,(H,29,36)(H,28,30,31)
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n/an/a 328n/an/an/an/an/an/a



SHANGHAI HAIYAN PHARMACEUTICAL TECHNOLOGY CO. LTD.

US Patent


Assay Description
The inhibitory effects of compounds to be tested on double mutant EGFR kinase (EGFR T790M/L858R Kinase) (Invitrogen, PV4879) and wild-type EGFR kinas...


US Patent US10435400 (2019)


BindingDB Entry DOI: 10.7270/Q20V8G4V
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM414557
PNG
(US10435400, Compound Z-97)
Show SMILES COc1cc(N2CCC(CC2)N(C)C)c(NC(=O)C=C)cc1Nc1ncc(Cl)c(n1)-c1cnn(C)c1C
Show InChI InChI=1S/C26H33ClN8O2/c1-7-24(36)30-20-12-21(23(37-6)13-22(20)35-10-8-17(9-11-35)33(3)4)31-26-28-15-19(27)25(32-26)18-14-29-34(5)16(18)2/h7,12-15,17H,1,8-11H2,2-6H3,(H,30,36)(H,28,31,32)
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n/an/a 341n/an/an/an/an/an/a



SHANGHAI HAIYAN PHARMACEUTICAL TECHNOLOGY CO. LTD.

US Patent


Assay Description
The inhibitory effects of compounds to be tested on double mutant EGFR kinase (EGFR T790M/L858R Kinase) (Invitrogen, PV4879) and wild-type EGFR kinas...


US Patent US10435400 (2019)


BindingDB Entry DOI: 10.7270/Q20V8G4V
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM414558
PNG
(US10435400, Compound Z-98)
Show SMILES COc1cc(N2CCC(CC2)N(C)C)c(NC(=O)C=C)cc1Nc1ncc(Cl)c(n1)-c1ccn(C)c1
Show InChI InChI=1S/C26H32ClN7O2/c1-6-24(35)29-20-13-21(23(36-5)14-22(20)34-11-8-18(9-12-34)32(2)3)30-26-28-15-19(27)25(31-26)17-7-10-33(4)16-17/h6-7,10,13-16,18H,1,8-9,11-12H2,2-5H3,(H,29,35)(H,28,30,31)
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n/an/a 407n/an/an/an/an/an/a



SHANGHAI HAIYAN PHARMACEUTICAL TECHNOLOGY CO. LTD.

US Patent


Assay Description
The inhibitory effects of compounds to be tested on double mutant EGFR kinase (EGFR T790M/L858R Kinase) (Invitrogen, PV4879) and wild-type EGFR kinas...


US Patent US10435400 (2019)


BindingDB Entry DOI: 10.7270/Q20V8G4V
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%