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Patent code US10442803

Compile Data Set for Download or QSAR

Found 546 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
BRD4 - BD1


(Homo sapiens (Human))
BDBM343587
PNG
(US10442803, Example 186 | US9777003, Example 186)
Show SMILES Cc1nnc2ccc3n(Cc4ccccc4)c(cc3n12)C1CCNC1
Show InChI InChI=1S/C20H21N5/c1-14-22-23-20-8-7-17-19(25(14)20)11-18(16-9-10-21-12-16)24(17)13-15-5-3-2-4-6-15/h2-8,11,16,21H,9-10,12-13H2,1H3
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Incyte Corporation

US Patent


Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 20 μL for BD1 and 40 μL for BD2. Inhib...


US Patent US10442803 (2019)


BindingDB Entry DOI: 10.7270/Q2X069DC
More data for this
Ligand-Target Pair
BRD4 - BD1


(Homo sapiens (Human))
BDBM343517
PNG
(US10442803, Example 116 | US9777003, Example 116)
Show SMILES Cc1nnc2ccc3n(Cc4cccc(Cl)c4)c(cc3n12)C(=O)N1CCOCC1
Show InChI InChI=1S/C21H20ClN5O2/c1-14-23-24-20-6-5-17-18(27(14)20)12-19(21(28)25-7-9-29-10-8-25)26(17)13-15-3-2-4-16(22)11-15/h2-6,11-12H,7-10,13H2,1H3
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Incyte Corporation

US Patent


Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 20 μL for BD1 and 40 μL for BD2. Inhib...


US Patent US10442803 (2019)


BindingDB Entry DOI: 10.7270/Q2X069DC
More data for this
Ligand-Target Pair
BRD4 - BD2


(Homo sapiens (Human))
BDBM343588
PNG
(US10442803, Example 187 | US9777003, Example 187)
Show SMILES CC(=O)N1CCC(C1)c1cc2c(ccc3nnc(C)n23)n1Cc1ccccc1
Show InChI InChI=1S/C22H23N5O/c1-15-23-24-22-9-8-19-21(27(15)22)12-20(18-10-11-25(14-18)16(2)28)26(19)13-17-6-4-3-5-7-17/h3-9,12,18H,10-11,13-14H2,1-2H3
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Incyte Corporation

US Patent


Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 20 μL for BD1 and 40 μL for BD2. Inhib...


US Patent US10442803 (2019)


BindingDB Entry DOI: 10.7270/Q2X069DC
More data for this
Ligand-Target Pair
BRD4 - BD2


(Homo sapiens (Human))
BDBM343517
PNG
(US10442803, Example 116 | US9777003, Example 116)
Show SMILES Cc1nnc2ccc3n(Cc4cccc(Cl)c4)c(cc3n12)C(=O)N1CCOCC1
Show InChI InChI=1S/C21H20ClN5O2/c1-14-23-24-20-6-5-17-18(27(14)20)12-19(21(28)25-7-9-29-10-8-25)26(17)13-15-3-2-4-16(22)11-15/h2-6,11-12H,7-10,13H2,1H3
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Incyte Corporation

US Patent


Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 20 μL for BD1 and 40 μL for BD2. Inhib...


US Patent US10442803 (2019)


BindingDB Entry DOI: 10.7270/Q2X069DC
More data for this
Ligand-Target Pair
BRD4 - BD1


(Homo sapiens (Human))
BDBM343462
PNG
(US10442803, Example 61 | US9777003, Example 61)
Show SMILES Cc1nnc2ccc3n(Cc4ccccc4)c(CCO)cc3n12
Show InChI InChI=1S/C18H18N4O/c1-13-19-20-18-8-7-16-17(22(13)18)11-15(9-10-23)21(16)12-14-5-3-2-4-6-14/h2-8,11,23H,9-10,12H2,1H3
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Incyte Corporation

US Patent


Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 20 μL for BD1 and 40 μL for BD2. Inhib...


US Patent US10442803 (2019)


BindingDB Entry DOI: 10.7270/Q2X069DC
More data for this
Ligand-Target Pair
BRD4 - BD2


(Homo sapiens (Human))
BDBM343525
PNG
(US10442803, Example 124 | US9777003, Example 124)
Show SMILES Cc1nnc2ccc3n(Cc4ccccc4)c(cc3n12)C(=O)NCC1CNC1
Show InChI InChI=1S/C21H22N6O/c1-14-24-25-20-8-7-17-18(27(14)20)9-19(21(28)23-12-16-10-22-11-16)26(17)13-15-5-3-2-4-6-15/h2-9,16,22H,10-13H2,1H3,(H,23,28)
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Incyte Corporation

US Patent


Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 20 μL for BD1 and 40 μL for BD2. Inhib...


US Patent US10442803 (2019)


BindingDB Entry DOI: 10.7270/Q2X069DC
More data for this
Ligand-Target Pair
BRD4 - BD2


(Homo sapiens (Human))
BDBM343472
PNG
(US10442803, Example 71 | US9777003, Example 71)
Show SMILES Cc1nnc2ccc3n(Cc4ccccc4)c(cc3n12)-c1cncn1C
Show InChI InChI=1S/C20H18N6/c1-14-22-23-20-9-8-16-18(26(14)20)10-17(19-11-21-13-24(19)2)25(16)12-15-6-4-3-5-7-15/h3-11,13H,12H2,1-2H3
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Incyte Corporation

US Patent


Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 20 μL for BD1 and 40 μL for BD2. Inhib...


US Patent US10442803 (2019)


BindingDB Entry DOI: 10.7270/Q2X069DC
More data for this
Ligand-Target Pair
BRD4 - BD1


(Homo sapiens (Human))
BDBM343588
PNG
(US10442803, Example 187 | US9777003, Example 187)
Show SMILES CC(=O)N1CCC(C1)c1cc2c(ccc3nnc(C)n23)n1Cc1ccccc1
Show InChI InChI=1S/C22H23N5O/c1-15-23-24-22-9-8-19-21(27(15)22)12-20(18-10-11-25(14-18)16(2)28)26(19)13-17-6-4-3-5-7-17/h3-9,12,18H,10-11,13-14H2,1-2H3
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Incyte Corporation

US Patent


Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 20 μL for BD1 and 40 μL for BD2. Inhib...


US Patent US10442803 (2019)


BindingDB Entry DOI: 10.7270/Q2X069DC
More data for this
Ligand-Target Pair
BRD4 - BD1


(Homo sapiens (Human))
BDBM343458
PNG
(US10442803, Example 57 | US9777003, Example 57)
Show SMILES Cc1nnc2ccc3n(Cc4ccccc4)c(Cn4ccnc4)cc3n12
Show InChI InChI=1S/C20H18N6/c1-15-22-23-20-8-7-18-19(26(15)20)11-17(13-24-10-9-21-14-24)25(18)12-16-5-3-2-4-6-16/h2-11,14H,12-13H2,1H3
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Incyte Corporation

US Patent


Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 20 μL for BD1 and 40 μL for BD2. Inhib...


US Patent US10442803 (2019)


BindingDB Entry DOI: 10.7270/Q2X069DC
More data for this
Ligand-Target Pair
BRD4 - BD1


(Homo sapiens (Human))
BDBM343525
PNG
(US10442803, Example 124 | US9777003, Example 124)
Show SMILES Cc1nnc2ccc3n(Cc4ccccc4)c(cc3n12)C(=O)NCC1CNC1
Show InChI InChI=1S/C21H22N6O/c1-14-24-25-20-8-7-17-18(27(14)20)9-19(21(28)23-12-16-10-22-11-16)26(17)13-15-5-3-2-4-6-15/h2-9,16,22H,10-13H2,1H3,(H,23,28)
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Incyte Corporation

US Patent


Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 20 μL for BD1 and 40 μL for BD2. Inhib...


US Patent US10442803 (2019)


BindingDB Entry DOI: 10.7270/Q2X069DC
More data for this
Ligand-Target Pair
BRD4 - BD2


(Homo sapiens (Human))
BDBM415718
PNG
(US10442803, Example 5)
Show SMILES C[C@@H](c1ccccc1)n1c(C)cc2c1ccc1nnc(C)n21
Show InChI InChI=1S/C18H18N4/c1-12-11-17-16(9-10-18-20-19-14(3)22(17)18)21(12)13(2)15-7-5-4-6-8-15/h4-11,13H,1-3H3/t13-/m0/s1
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Incyte Corporation

US Patent


Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 20 μL for BD1 and 40 μL for BD2. Inhib...


US Patent US10442803 (2019)


BindingDB Entry DOI: 10.7270/Q2X069DC
More data for this
Ligand-Target Pair
BRD4 - BD1


(Homo sapiens (Human))
BDBM343418
PNG
(US10442803, Example 17 | US9777003, Example 17)
Show SMILES Cc1cc2c(ccc3nnc(C)n23)n1Cc1ccccc1C
Show InChI InChI=1S/C18H18N4/c1-12-6-4-5-7-15(12)11-21-13(2)10-17-16(21)8-9-18-20-19-14(3)22(17)18/h4-10H,11H2,1-3H3
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Incyte Corporation

US Patent


Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 20 μL for BD1 and 40 μL for BD2. Inhib...


US Patent US10442803 (2019)


BindingDB Entry DOI: 10.7270/Q2X069DC
More data for this
Ligand-Target Pair
BRD4 - BD2


(Homo sapiens (Human))
BDBM343435
PNG
(US10442803, Example 34 | US9777003, Example 34)
Show SMILES COc1ccc(Cn2c(C)cc3c2ccc2nnc(C)n32)cc1
Show InChI InChI=1S/C18H18N4O/c1-12-10-17-16(8-9-18-20-19-13(2)22(17)18)21(12)11-14-4-6-15(23-3)7-5-14/h4-10H,11H2,1-3H3
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Incyte Corporation

US Patent


Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 20 μL for BD1 and 40 μL for BD2. Inhib...


US Patent US10442803 (2019)


BindingDB Entry DOI: 10.7270/Q2X069DC
More data for this
Ligand-Target Pair
BRD4 - BD1


(Homo sapiens (Human))
BDBM343437
PNG
(US10442803, Example 36 | US9777003, Example 36)
Show SMILES Cc1cc2c(ccc3nnc(C)n23)n1Cc1cccc(CNCCO)c1
Show InChI InChI=1S/C20H23N5O/c1-14-10-19-18(6-7-20-23-22-15(2)25(19)20)24(14)13-17-5-3-4-16(11-17)12-21-8-9-26/h3-7,10-11,21,26H,8-9,12-13H2,1-2H3
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Incyte Corporation

US Patent


Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 20 μL for BD1 and 40 μL for BD2. Inhib...


US Patent US10442803 (2019)


BindingDB Entry DOI: 10.7270/Q2X069DC
More data for this
Ligand-Target Pair
BRD4 - BD2


(Homo sapiens (Human))
BDBM343440
PNG
(US10442803, Example 39 | US9777003, Example 39)
Show SMILES Cc1cc2c(ccc3nnc(C)n23)n1Cc1cccc(CN[C@H]2C[C@H](O)C2)c1
Show InChI InChI=1S/C22H25N5O/c1-14-8-21-20(6-7-22-25-24-15(2)27(21)22)26(14)13-17-5-3-4-16(9-17)12-23-18-10-19(28)11-18/h3-9,18-19,23,28H,10-13H2,1-2H3/t18-,19-
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Incyte Corporation

US Patent


Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 20 μL for BD1 and 40 μL for BD2. Inhib...


US Patent US10442803 (2019)


BindingDB Entry DOI: 10.7270/Q2X069DC
More data for this
Ligand-Target Pair
BRD4 - BD2


(Homo sapiens (Human))
BDBM343441
PNG
(US10442803, Example 40 | US9777003, Example 40)
Show SMILES CN(C)Cc1cccc(Cn2c(C)cc3c2ccc2nnc(C)n32)c1
Show InChI InChI=1S/C20H23N5/c1-14-10-19-18(8-9-20-22-21-15(2)25(19)20)24(14)13-17-7-5-6-16(11-17)12-23(3)4/h5-11H,12-13H2,1-4H3
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Incyte Corporation

US Patent


Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 20 μL for BD1 and 40 μL for BD2. Inhib...


US Patent US10442803 (2019)


BindingDB Entry DOI: 10.7270/Q2X069DC
More data for this
Ligand-Target Pair
BRD4 - BD2


(Homo sapiens (Human))
BDBM343444
PNG
(US10442803, Example 43 | US9777003, Example 43)
Show SMILES CCNC(=O)Nc1cccc(Cn2c(C)cc3c2ccc2nnc(C)n32)c1
Show InChI InChI=1S/C20H22N6O/c1-4-21-20(27)22-16-7-5-6-15(11-16)12-25-13(2)10-18-17(25)8-9-19-24-23-14(3)26(18)19/h5-11H,4,12H2,1-3H3,(H2,21,22,27)
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Incyte Corporation

US Patent


Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 20 μL for BD1 and 40 μL for BD2. Inhib...


US Patent US10442803 (2019)


BindingDB Entry DOI: 10.7270/Q2X069DC
More data for this
Ligand-Target Pair
BRD4 - BD2


(Homo sapiens (Human))
BDBM343451
PNG
(US10442803, Example 50 | US9777003, Example 50)
Show SMILES Cc1cc2c(ccc3nnc(C)n23)n1Cc1ccc(CN2CCC2)cc1
Show InChI InChI=1S/C21H23N5/c1-15-12-20-19(8-9-21-23-22-16(2)26(20)21)25(15)14-18-6-4-17(5-7-18)13-24-10-3-11-24/h4-9,12H,3,10-11,13-14H2,1-2H3
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Incyte Corporation

US Patent


Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 20 μL for BD1 and 40 μL for BD2. Inhib...


US Patent US10442803 (2019)


BindingDB Entry DOI: 10.7270/Q2X069DC
More data for this
Ligand-Target Pair
BRD4 - BD2


(Homo sapiens (Human))
BDBM343456
PNG
(US10442803, Example 55 | US9777003, Example 55)
Show SMILES Cc1nc2c(ccc3nnc(C)n23)n1Cc1ccccc1
Show InChI InChI=1S/C16H15N5/c1-11-17-16-14(8-9-15-19-18-12(2)21(15)16)20(11)10-13-6-4-3-5-7-13/h3-9H,10H2,1-2H3
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Incyte Corporation

US Patent


Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 20 μL for BD1 and 40 μL for BD2. Inhib...


US Patent US10442803 (2019)


BindingDB Entry DOI: 10.7270/Q2X069DC
More data for this
Ligand-Target Pair
BRD4 - BD2


(Homo sapiens (Human))
BDBM343467
PNG
(US10442803, Example 66 | US9777003, Example 66)
Show SMILES Cc1nnc2ccc3n(Cc4ccccc4)c(cc3n12)-c1cscn1
Show InChI InChI=1S/C19H15N5S/c1-13-21-22-19-8-7-16-18(24(13)19)9-17(15-11-25-12-20-15)23(16)10-14-5-3-2-4-6-14/h2-9,11-12H,10H2,1H3
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Incyte Corporation

US Patent


Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 20 μL for BD1 and 40 μL for BD2. Inhib...


US Patent US10442803 (2019)


BindingDB Entry DOI: 10.7270/Q2X069DC
More data for this
Ligand-Target Pair
BRD4 - BD2


(Homo sapiens (Human))
BDBM343468
PNG
(US10442803, Example 67 | US9777003, Example 67)
Show SMILES Cc1nnc2ccc3n(Cc4ccccc4)c(cc3n12)-c1nccs1
Show InChI InChI=1S/C19H15N5S/c1-13-21-22-18-8-7-15-16(24(13)18)11-17(19-20-9-10-25-19)23(15)12-14-5-3-2-4-6-14/h2-11H,12H2,1H3
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n/an/a<1.00E+3n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 20 μL for BD1 and 40 μL for BD2. Inhib...


US Patent US10442803 (2019)


BindingDB Entry DOI: 10.7270/Q2X069DC
More data for this
Ligand-Target Pair
BRD4 - BD1


(Homo sapiens (Human))
BDBM343475
PNG
(US10442803, Example 74 | US9777003, Example 74)
Show SMILES Cc1nnc2ccc3n(Cc4ccccc4)c(cc3n12)-c1c[nH]cn1
Show InChI InChI=1S/C19H16N6/c1-13-22-23-19-8-7-16-18(25(13)19)9-17(15-10-20-12-21-15)24(16)11-14-5-3-2-4-6-14/h2-10,12H,11H2,1H3,(H,20,21)
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Incyte Corporation

US Patent


Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 20 μL for BD1 and 40 μL for BD2. Inhib...


US Patent US10442803 (2019)


BindingDB Entry DOI: 10.7270/Q2X069DC
More data for this
Ligand-Target Pair
BRD4 - BD1


(Homo sapiens (Human))
BDBM343501
PNG
(US10442803, Example 100 | US9777003, Example 100)
Show SMILES Cc1nnc2ccc3n(Cc4ccccc4)c(cc3n12)C(=O)N[C@H]1C[C@@H](C1)C#N
Show InChI InChI=1S/C22H20N6O/c1-14-25-26-21-8-7-18-19(28(14)21)11-20(22(29)24-17-9-16(10-17)12-23)27(18)13-15-5-3-2-4-6-15/h2-8,11,16-17H,9-10,13H2,1H3,(H,24,29)/t16-,17-
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Incyte Corporation

US Patent


Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 20 μL for BD1 and 40 μL for BD2. Inhib...


US Patent US10442803 (2019)


BindingDB Entry DOI: 10.7270/Q2X069DC
More data for this
Ligand-Target Pair
BRD4 - BD2


(Homo sapiens (Human))
BDBM343508
PNG
(US10442803, Example 107 | US9777003, Example 107)
Show SMILES Cc1nnc2ccc3n(Cc4cccc(Cl)c4)c(cc3n12)-c1ccn(n1)C1(CC#N)CN(C1)S(C)(=O)=O
Show InChI InChI=1S/C25H23ClN8O2S/c1-17-28-29-24-7-6-21-23(34(17)24)13-22(32(21)14-18-4-3-5-19(26)12-18)20-8-11-33(30-20)25(9-10-27)15-31(16-25)37(2,35)36/h3-8,11-13H,9,14-16H2,1-2H3
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Incyte Corporation

US Patent


Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 20 μL for BD1 and 40 μL for BD2. Inhib...


US Patent US10442803 (2019)


BindingDB Entry DOI: 10.7270/Q2X069DC
More data for this
Ligand-Target Pair
BRD4 - BD1


(Homo sapiens (Human))
BDBM343514
PNG
(US10442803, Example 113 | US9777003, Example 113)
Show SMILES CCNC(=O)c1cc2c(ccc3nnc(C)n23)n1Cc1cccc(Cl)c1
Show InChI InChI=1S/C19H18ClN5O/c1-3-21-19(26)17-10-16-15(7-8-18-23-22-12(2)25(16)18)24(17)11-13-5-4-6-14(20)9-13/h4-10H,3,11H2,1-2H3,(H,21,26)
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Incyte Corporation

US Patent


Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 20 μL for BD1 and 40 μL for BD2. Inhib...


US Patent US10442803 (2019)


BindingDB Entry DOI: 10.7270/Q2X069DC
More data for this
Ligand-Target Pair
BRD4 - BD2


(Homo sapiens (Human))
BDBM343514
PNG
(US10442803, Example 113 | US9777003, Example 113)
Show SMILES CCNC(=O)c1cc2c(ccc3nnc(C)n23)n1Cc1cccc(Cl)c1
Show InChI InChI=1S/C19H18ClN5O/c1-3-21-19(26)17-10-16-15(7-8-18-23-22-12(2)25(16)18)24(17)11-13-5-4-6-14(20)9-13/h4-10H,3,11H2,1-2H3,(H,21,26)
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Incyte Corporation

US Patent


Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 20 μL for BD1 and 40 μL for BD2. Inhib...


US Patent US10442803 (2019)


BindingDB Entry DOI: 10.7270/Q2X069DC
More data for this
Ligand-Target Pair
BRD4 - BD1


(Homo sapiens (Human))
BDBM343515
PNG
(US10442803, Example 114 | US9777003, Example 114)
Show SMILES Cc1nnc2ccc3n(Cc4cccc(Cl)c4)c(cc3n12)C(=O)NCC1CC1
Show InChI InChI=1S/C21H20ClN5O/c1-13-24-25-20-8-7-17-18(27(13)20)10-19(21(28)23-11-14-5-6-14)26(17)12-15-3-2-4-16(22)9-15/h2-4,7-10,14H,5-6,11-12H2,1H3,(H,23,28)
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n/an/a<1.00E+3n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 20 μL for BD1 and 40 μL for BD2. Inhib...


US Patent US10442803 (2019)


BindingDB Entry DOI: 10.7270/Q2X069DC
More data for this
Ligand-Target Pair
BRD4 - BD1


(Homo sapiens (Human))
BDBM343518
PNG
(US10442803, Example 117 | US9777003, Example 117)
Show SMILES Cc1nnc2ccc3n(Cc4cccc(Cl)c4)c(cc3n12)C(=O)NCCO
Show InChI InChI=1S/C19H18ClN5O2/c1-12-22-23-18-6-5-15-16(25(12)18)10-17(19(27)21-7-8-26)24(15)11-13-3-2-4-14(20)9-13/h2-6,9-10,26H,7-8,11H2,1H3,(H,21,27)
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Incyte Corporation

US Patent


Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 20 μL for BD1 and 40 μL for BD2. Inhib...


US Patent US10442803 (2019)


BindingDB Entry DOI: 10.7270/Q2X069DC
More data for this
Ligand-Target Pair
BRD4 - BD2


(Homo sapiens (Human))
BDBM343518
PNG
(US10442803, Example 117 | US9777003, Example 117)
Show SMILES Cc1nnc2ccc3n(Cc4cccc(Cl)c4)c(cc3n12)C(=O)NCCO
Show InChI InChI=1S/C19H18ClN5O2/c1-12-22-23-18-6-5-15-16(25(12)18)10-17(19(27)21-7-8-26)24(15)11-13-3-2-4-14(20)9-13/h2-6,9-10,26H,7-8,11H2,1H3,(H,21,27)
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Incyte Corporation

US Patent


Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 20 μL for BD1 and 40 μL for BD2. Inhib...


US Patent US10442803 (2019)


BindingDB Entry DOI: 10.7270/Q2X069DC
More data for this
Ligand-Target Pair
BRD4 - BD1


(Homo sapiens (Human))
BDBM343522
PNG
(US10442803, Example 121 | US9777003, Example 121)
Show SMILES CCNC(=O)c1cc2c(ccc3nnc(C)n23)n1Cc1cccc(CN2CCC2)c1
Show InChI InChI=1S/C23H26N6O/c1-3-24-23(30)21-13-20-19(8-9-22-26-25-16(2)29(20)22)28(21)15-18-7-4-6-17(12-18)14-27-10-5-11-27/h4,6-9,12-13H,3,5,10-11,14-15H2,1-2H3,(H,24,30)
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Incyte Corporation

US Patent


Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 20 μL for BD1 and 40 μL for BD2. Inhib...


US Patent US10442803 (2019)


BindingDB Entry DOI: 10.7270/Q2X069DC
More data for this
Ligand-Target Pair
BRD4 - BD2


(Homo sapiens (Human))
BDBM343522
PNG
(US10442803, Example 121 | US9777003, Example 121)
Show SMILES CCNC(=O)c1cc2c(ccc3nnc(C)n23)n1Cc1cccc(CN2CCC2)c1
Show InChI InChI=1S/C23H26N6O/c1-3-24-23(30)21-13-20-19(8-9-22-26-25-16(2)29(20)22)28(21)15-18-7-4-6-17(12-18)14-27-10-5-11-27/h4,6-9,12-13H,3,5,10-11,14-15H2,1-2H3,(H,24,30)
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Incyte Corporation

US Patent


Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 20 μL for BD1 and 40 μL for BD2. Inhib...


US Patent US10442803 (2019)


BindingDB Entry DOI: 10.7270/Q2X069DC
More data for this
Ligand-Target Pair
BRD4 - BD1


(Homo sapiens (Human))
BDBM343523
PNG
(US10442803, Example 122 | US9777003, Example 122)
Show SMILES CNC(=O)c1cc2c(ccc3nnc(C)n23)n1Cc1cccc(CN2CCC2)c1
Show InChI InChI=1S/C22H24N6O/c1-15-24-25-21-8-7-18-19(28(15)21)12-20(22(29)23-2)27(18)14-17-6-3-5-16(11-17)13-26-9-4-10-26/h3,5-8,11-12H,4,9-10,13-14H2,1-2H3,(H,23,29)
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Incyte Corporation

US Patent


Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 20 μL for BD1 and 40 μL for BD2. Inhib...


US Patent US10442803 (2019)


BindingDB Entry DOI: 10.7270/Q2X069DC
More data for this
Ligand-Target Pair
BRD4 - BD2


(Homo sapiens (Human))
BDBM343524
PNG
(US10442803, Example 123 | US9777003, Example 123)
Show SMILES Cc1nnc2ccc3n(Cc4ccccc4)c(cc3n12)C(=O)NCCCO
Show InChI InChI=1S/C20H21N5O2/c1-14-22-23-19-9-8-16-17(25(14)19)12-18(20(27)21-10-5-11-26)24(16)13-15-6-3-2-4-7-15/h2-4,6-9,12,26H,5,10-11,13H2,1H3,(H,21,27)
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Incyte Corporation

US Patent


Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 20 μL for BD1 and 40 μL for BD2. Inhib...


US Patent US10442803 (2019)


BindingDB Entry DOI: 10.7270/Q2X069DC
More data for this
Ligand-Target Pair
BRD4 - BD2


(Homo sapiens (Human))
BDBM343533
PNG
(US10442803, Example 132 | US9777003, Example 132)
Show SMILES CNC(=O)c1cc2c(ccc3nnc(C)n23)n1Cc1cc(Cl)cc(CN2CCCC2)c1
Show InChI InChI=1S/C23H25ClN6O/c1-15-26-27-22-6-5-19-20(30(15)22)12-21(23(31)25-2)29(19)14-17-9-16(10-18(24)11-17)13-28-7-3-4-8-28/h5-6,9-12H,3-4,7-8,13-14H2,1-2H3,(H,25,31)
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Incyte Corporation

US Patent


Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 20 μL for BD1 and 40 μL for BD2. Inhib...


US Patent US10442803 (2019)


BindingDB Entry DOI: 10.7270/Q2X069DC
More data for this
Ligand-Target Pair
BRD4 - BD1


(Homo sapiens (Human))
BDBM343534
PNG
(US10442803, Example 133 | US9777003, Example 133)
Show SMILES CCNC(=O)c1cc2c(ccc3nnc(C)n23)n1Cc1cc(Cl)cc(CN2CCCC2)c1
Show InChI InChI=1S/C24H27ClN6O/c1-3-26-24(32)22-13-21-20(6-7-23-28-27-16(2)31(21)23)30(22)15-18-10-17(11-19(25)12-18)14-29-8-4-5-9-29/h6-7,10-13H,3-5,8-9,14-15H2,1-2H3,(H,26,32)
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Incyte Corporation

US Patent


Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 20 μL for BD1 and 40 μL for BD2. Inhib...


US Patent US10442803 (2019)


BindingDB Entry DOI: 10.7270/Q2X069DC
More data for this
Ligand-Target Pair
BRD4 - BD2


(Homo sapiens (Human))
BDBM343534
PNG
(US10442803, Example 133 | US9777003, Example 133)
Show SMILES CCNC(=O)c1cc2c(ccc3nnc(C)n23)n1Cc1cc(Cl)cc(CN2CCCC2)c1
Show InChI InChI=1S/C24H27ClN6O/c1-3-26-24(32)22-13-21-20(6-7-23-28-27-16(2)31(21)23)30(22)15-18-10-17(11-19(25)12-18)14-29-8-4-5-9-29/h6-7,10-13H,3-5,8-9,14-15H2,1-2H3,(H,26,32)
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Incyte Corporation

US Patent


Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 20 μL for BD1 and 40 μL for BD2. Inhib...


US Patent US10442803 (2019)


BindingDB Entry DOI: 10.7270/Q2X069DC
More data for this
Ligand-Target Pair
BRD4 - BD2


(Homo sapiens (Human))
BDBM343543
PNG
(US10442803, Example 142 | US9777003, Example 142)
Show SMILES CNC(=O)Nc1cc2n(Cc3cc(Cl)cc(CN4CCCC4)c3)c(C)cc2n2c(C)nnc12
Show InChI InChI=1S/C24H28ClN7O/c1-15-8-22-21(12-20(27-24(33)26-3)23-29-28-16(2)32(22)23)31(15)14-18-9-17(10-19(25)11-18)13-30-6-4-5-7-30/h8-12H,4-7,13-14H2,1-3H3,(H2,26,27,33)
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Incyte Corporation

US Patent


Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 20 μL for BD1 and 40 μL for BD2. Inhib...


US Patent US10442803 (2019)


BindingDB Entry DOI: 10.7270/Q2X069DC
More data for this
Ligand-Target Pair
BRD4 - BD1


(Homo sapiens (Human))
BDBM343544
PNG
(US10442803, Example 143 | US9777003, Example 143)
Show SMILES Cc1nnc2ccc3n(Cc4ccccc4)c(cc3n12)-c1ncco1
Show InChI InChI=1S/C19H15N5O/c1-13-21-22-18-8-7-15-16(24(13)18)11-17(19-20-9-10-25-19)23(15)12-14-5-3-2-4-6-14/h2-11H,12H2,1H3
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Incyte Corporation

US Patent


Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 20 μL for BD1 and 40 μL for BD2. Inhib...


US Patent US10442803 (2019)


BindingDB Entry DOI: 10.7270/Q2X069DC
More data for this
Ligand-Target Pair
BRD4 - BD2


(Homo sapiens (Human))
BDBM343547
PNG
(US10442803, Example 146 | US9777003, Example 146)
Show SMILES Cc1cc2c(cc(NC3CCOCC3)c3nnc(C)n23)n1Cc1ccccc1
Show InChI InChI=1S/C22H25N5O/c1-15-12-21-20(26(15)14-17-6-4-3-5-7-17)13-19(22-25-24-16(2)27(21)22)23-18-8-10-28-11-9-18/h3-7,12-13,18,23H,8-11,14H2,1-2H3
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Incyte Corporation

US Patent


Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 20 μL for BD1 and 40 μL for BD2. Inhib...


US Patent US10442803 (2019)


BindingDB Entry DOI: 10.7270/Q2X069DC
More data for this
Ligand-Target Pair
BRD4 - BD2


(Homo sapiens (Human))
BDBM343553
PNG
(US10442803, Example 152 | US9777003, Example 152)
Show SMILES Cc1cc2c(cc(N[C@H]3CCNC3)c3nnc(C)n23)n1Cc1ccccc1
Show InChI InChI=1S/C21H24N6/c1-14-10-20-19(26(14)13-16-6-4-3-5-7-16)11-18(23-17-8-9-22-12-17)21-25-24-15(2)27(20)21/h3-7,10-11,17,22-23H,8-9,12-13H2,1-2H3/t17-/m0/s1
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Incyte Corporation

US Patent


Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 20 μL for BD1 and 40 μL for BD2. Inhib...


US Patent US10442803 (2019)


BindingDB Entry DOI: 10.7270/Q2X069DC
More data for this
Ligand-Target Pair
BRD4 - BD1


(Homo sapiens (Human))
BDBM343556
PNG
(US10442803, Example 155 | US9777003, Example 155)
Show SMILES Cc1nnc2ccc3n(Cc4cccc(Cl)c4)c(cc3n12)-c1ccn[nH]1
Show InChI InChI=1S/C19H15ClN6/c1-12-22-24-19-6-5-16-18(26(12)19)10-17(15-7-8-21-23-15)25(16)11-13-3-2-4-14(20)9-13/h2-10H,11H2,1H3,(H,21,23)
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Incyte Corporation

US Patent


Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 20 μL for BD1 and 40 μL for BD2. Inhib...


US Patent US10442803 (2019)


BindingDB Entry DOI: 10.7270/Q2X069DC
More data for this
Ligand-Target Pair
BRD4 - BD2


(Homo sapiens (Human))
BDBM343561
PNG
(US10442803, Example 160 | US9777003, Example 160)
Show SMILES CCN1CC(C1)n1ccc(n1)-c1cc2c(ccc3nnc(C)n23)n1Cc1cccc(Cl)c1
Show InChI InChI=1S/C24H24ClN7/c1-3-29-14-19(15-29)31-10-9-20(28-31)22-12-23-21(7-8-24-27-26-16(2)32(23)24)30(22)13-17-5-4-6-18(25)11-17/h4-12,19H,3,13-15H2,1-2H3
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Incyte Corporation

US Patent


Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 20 μL for BD1 and 40 μL for BD2. Inhib...


US Patent US10442803 (2019)


BindingDB Entry DOI: 10.7270/Q2X069DC
More data for this
Ligand-Target Pair
BRD4 - BD2


(Homo sapiens (Human))
BDBM343564
PNG
(US10442803, Example 163 | US9777003, Example 163)
Show SMILES CCC(=O)N1CC(C1)n1ccc(n1)-c1cc2c(ccc3nnc(C)n23)n1Cc1cccc(Cl)c1
Show InChI InChI=1S/C25H24ClN7O/c1-3-25(34)30-14-19(15-30)32-10-9-20(29-32)22-12-23-21(7-8-24-28-27-16(2)33(23)24)31(22)13-17-5-4-6-18(26)11-17/h4-12,19H,3,13-15H2,1-2H3
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Incyte Corporation

US Patent


Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 20 μL for BD1 and 40 μL for BD2. Inhib...


US Patent US10442803 (2019)


BindingDB Entry DOI: 10.7270/Q2X069DC
More data for this
Ligand-Target Pair
BRD4 - BD1


(Homo sapiens (Human))
BDBM343566
PNG
(US10442803, Example 165 | US9777003, Example 165)
Show SMILES Cc1nnc2ccc3n(Cc4cccc(Cl)c4)c(cc3n12)-c1ccn(n1)C1CN(C1)S(=O)(=O)C1CC1
Show InChI InChI=1S/C25H24ClN7O2S/c1-16-27-28-25-8-7-22-24(33(16)25)12-23(31(22)13-17-3-2-4-18(26)11-17)21-9-10-32(29-21)19-14-30(15-19)36(34,35)20-5-6-20/h2-4,7-12,19-20H,5-6,13-15H2,1H3
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Incyte Corporation

US Patent


Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 20 μL for BD1 and 40 μL for BD2. Inhib...


US Patent US10442803 (2019)


BindingDB Entry DOI: 10.7270/Q2X069DC
More data for this
Ligand-Target Pair
BRD4 - BD2


(Homo sapiens (Human))
BDBM343578
PNG
(US10442803, Example 177 | US9777003, Example 177)
Show SMILES Cc1nnc2ccc3n(Cc4cccc(Cl)c4)c(cc3n12)-c1ccn(n1)C1COC1
Show InChI InChI=1S/C22H19ClN6O/c1-14-24-25-22-6-5-19-21(29(14)22)10-20(18-7-8-28(26-18)17-12-30-13-17)27(19)11-15-3-2-4-16(23)9-15/h2-10,17H,11-13H2,1H3
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Incyte Corporation

US Patent


Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 20 μL for BD1 and 40 μL for BD2. Inhib...


US Patent US10442803 (2019)


BindingDB Entry DOI: 10.7270/Q2X069DC
More data for this
Ligand-Target Pair
BRD4 - BD1


(Homo sapiens (Human))
BDBM343585
PNG
(US10442803, Example 184 | US9777003, Example 184)
Show SMILES Cc1nnc2ccc3n(Cc4cccc(CN5CCC5)c4)c(cc3n12)-c1ccn(C)n1
Show InChI InChI=1S/C24H25N7/c1-17-25-26-24-8-7-21-23(31(17)24)14-22(20-9-12-28(2)27-20)30(21)16-19-6-3-5-18(13-19)15-29-10-4-11-29/h3,5-9,12-14H,4,10-11,15-16H2,1-2H3
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Incyte Corporation

US Patent


Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 20 μL for BD1 and 40 μL for BD2. Inhib...


US Patent US10442803 (2019)


BindingDB Entry DOI: 10.7270/Q2X069DC
More data for this
Ligand-Target Pair
BRD4 - BD1


(Homo sapiens (Human))
BDBM343590
PNG
(US10442803, Example 189 | US9777003, Example 189)
Show SMILES CCn1ccc(n1)-c1cc2c(ccc3nnc(C)n23)n1Cc1cc(Cl)cc(CN2CCCC2)c1
Show InChI InChI=1S/C26H28ClN7/c1-3-32-11-8-22(30-32)24-15-25-23(6-7-26-29-28-18(2)34(25)26)33(24)17-20-12-19(13-21(27)14-20)16-31-9-4-5-10-31/h6-8,11-15H,3-5,9-10,16-17H2,1-2H3
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Incyte Corporation

US Patent


Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 20 μL for BD1 and 40 μL for BD2. Inhib...


US Patent US10442803 (2019)


BindingDB Entry DOI: 10.7270/Q2X069DC
More data for this
Ligand-Target Pair
BRD4 - BD1


(Homo sapiens (Human))
BDBM343591
PNG
(US10442803, Example 190 | US9777003, Example 190)
Show SMILES Cc1nnc2ccc3n(Cc4cc(Cl)cc(CN5CCCC5)c4)c(cc3n12)-c1ccn(C)n1
Show InChI InChI=1S/C25H26ClN7/c1-17-27-28-25-6-5-22-24(33(17)25)14-23(21-7-10-30(2)29-21)32(22)16-19-11-18(12-20(26)13-19)15-31-8-3-4-9-31/h5-7,10-14H,3-4,8-9,15-16H2,1-2H3
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Incyte Corporation

US Patent


Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 20 μL for BD1 and 40 μL for BD2. Inhib...


US Patent US10442803 (2019)


BindingDB Entry DOI: 10.7270/Q2X069DC
More data for this
Ligand-Target Pair
BRD4 - BD2


(Homo sapiens (Human))
BDBM343600
PNG
(US10442803, Example 199 | US9777003, Example 199)
Show SMILES Cc1nnc2ccc3n(Cc4cc(Cl)cc(CN5CCC(O)C5)c4)c(cc3n12)-c1ncco1
Show InChI InChI=1S/C24H23ClN6O2/c1-15-27-28-23-3-2-20-21(31(15)23)11-22(24-26-5-7-33-24)30(20)13-17-8-16(9-18(25)10-17)12-29-6-4-19(32)14-29/h2-3,5,7-11,19,32H,4,6,12-14H2,1H3
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Incyte Corporation

US Patent


Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 20 μL for BD1 and 40 μL for BD2. Inhib...


US Patent US10442803 (2019)


BindingDB Entry DOI: 10.7270/Q2X069DC
More data for this
Ligand-Target Pair
BRD4 - BD2


(Homo sapiens (Human))
BDBM343601
PNG
(US10442803, Example 200 | US9777003, Example 200)
Show SMILES Cc1cc2c(cc(Nc3cc[nH]n3)c3nnc(C)n23)n1Cc1ccccc1
Show InChI InChI=1S/C20H19N7/c1-13-10-18-17(26(13)12-15-6-4-3-5-7-15)11-16(22-19-8-9-21-24-19)20-25-23-14(2)27(18)20/h3-11H,12H2,1-2H3,(H2,21,22,24)
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Incyte Corporation

US Patent


Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 20 μL for BD1 and 40 μL for BD2. Inhib...


US Patent US10442803 (2019)


BindingDB Entry DOI: 10.7270/Q2X069DC
More data for this
Ligand-Target Pair
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* indicates data uncertainty>20%