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Patent code US10442810

Compile Data Set for Download or QSAR

Found 438 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM396979
PNG
(US10442810, Example 41 | US9981975, Example 41)
Show SMILES CS(=O)(=O)N1CCC(CC1)c1cc(-c2ccc(NC(=O)c3cccn(-c4ccc(F)cc4)c3=O)cc2)c2c(N)ncnn12
Show InChI InChI=1S/C30H28FN7O4S/c1-43(41,42)36-15-12-20(13-16-36)26-17-25(27-28(32)33-18-34-38(26)27)19-4-8-22(9-5-19)35-29(39)24-3-2-14-37(30(24)40)23-10-6-21(31)7-11-23/h2-11,14,17-18,20H,12-13,15-16H2,1H3,(H,35,39)(H2,32,33,34)
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Assay Description
The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolved in DMSO were ...


US Patent US10442810 (2019)


BindingDB Entry DOI: 10.7270/Q2NG4T17
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))
BDBM396981
PNG
(US10442810, Example 43 | US9981975, Example 43)
Show SMILES CS(=O)(=O)N1CCC(CC1)c1cc(-c2ccc(NC(=O)c3cccn(-c4ccc(F)cc4)c3=O)cc2F)c2c(N)ncnn12
Show InChI InChI=1S/C30H27F2N7O4S/c1-44(42,43)37-13-10-18(11-14-37)26-16-24(27-28(33)34-17-35-39(26)27)22-9-6-20(15-25(22)32)36-29(40)23-3-2-12-38(30(23)41)21-7-4-19(31)5-8-21/h2-9,12,15-18H,10-11,13-14H2,1H3,(H,36,40)(H2,33,34,35)
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Assay Description
The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolved in DMSO were ...


US Patent US10442810 (2019)


BindingDB Entry DOI: 10.7270/Q2NG4T17
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))
BDBM396982
PNG
(US10442810, Example 44 | US9981975, Example 44)
Show SMILES CN(C)C(=O)N1CCC(CC1)c1cc(-c2ccc(NC(=O)c3cccn(-c4ccccc4)c3=O)cc2)c2c(N)ncnn12
Show InChI InChI=1S/C32H32N8O3/c1-37(2)32(43)38-17-14-22(15-18-38)27-19-26(28-29(33)34-20-35-40(27)28)21-10-12-23(13-11-21)36-30(41)25-9-6-16-39(31(25)42)24-7-4-3-5-8-24/h3-13,16,19-20,22H,14-15,17-18H2,1-2H3,(H,36,41)(H2,33,34,35)
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Assay Description
The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolved in DMSO were ...


US Patent US10442810 (2019)


BindingDB Entry DOI: 10.7270/Q2NG4T17
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM396989
PNG
(US10442810, Example 51 | US9981975, Example 51)
Show SMILES COCCN1CCC(CC1)c1cc(-c2ccc(NC(=O)c3cccn(-c4ccc(F)cc4)c3=O)cc2F)c2c(N)ncnn12
Show InChI InChI=1S/C32H31F2N7O3/c1-44-16-15-39-13-10-20(11-14-39)28-18-26(29-30(35)36-19-37-41(28)29)24-9-6-22(17-27(24)34)38-31(42)25-3-2-12-40(32(25)43)23-7-4-21(33)5-8-23/h2-9,12,17-20H,10-11,13-16H2,1H3,(H,38,42)(H2,35,36,37)
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Assay Description
The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolved in DMSO were ...


US Patent US10442810 (2019)


BindingDB Entry DOI: 10.7270/Q2NG4T17
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))
BDBM396990
PNG
(US10442810, Example 52 | US9981975, Example 52)
Show SMILES Nc1ncnn2c(cc(-c3ccc(NC(=O)c4cccn(-c5ccccc5)c4=O)cc3)c12)C1CCN(CCO)CC1
Show InChI InChI=1S/C31H31N7O3/c32-29-28-26(19-27(38(28)34-20-33-29)22-12-15-36(16-13-22)17-18-39)21-8-10-23(11-9-21)35-30(40)25-7-4-14-37(31(25)41)24-5-2-1-3-6-24/h1-11,14,19-20,22,39H,12-13,15-18H2,(H,35,40)(H2,32,33,34)
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US Patent


Assay Description
The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolved in DMSO were ...


US Patent US10442810 (2019)


BindingDB Entry DOI: 10.7270/Q2NG4T17
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM397003
PNG
(US10442810, Example 65 | US9981975, Example 65)
Show SMILES CC(C)n1cc(C(=O)Nc2ccc(cc2)-c2cc(C3CCN(CC3)C(=O)N(C)C)n3ncnc(N)c23)c(=O)n(-c2ccc(F)cc2)c1=O
Show InChI InChI=1S/C34H36FN9O4/c1-20(2)42-18-27(32(46)43(34(42)48)25-11-7-23(35)8-12-25)31(45)39-24-9-5-21(6-10-24)26-17-28(44-29(26)30(36)37-19-38-44)22-13-15-41(16-14-22)33(47)40(3)4/h5-12,17-20,22H,13-16H2,1-4H3,(H,39,45)(H2,36,37,38)
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Assay Description
The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolved in DMSO were ...


US Patent US10442810 (2019)


BindingDB Entry DOI: 10.7270/Q2NG4T17
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM397010
PNG
(US10442810, Example 72 | US9981975, Example 72)
Show SMILES CCn1cc(C(=O)Nc2ccc(cc2)-c2cc(C3CCN(CC3)C(=O)N(C)C)n3ncnc(N)c23)c(=O)n(-c2cccc(F)c2)c1=O
Show InChI InChI=1S/C33H34FN9O4/c1-4-40-18-26(31(45)42(33(40)47)24-7-5-6-22(34)16-24)30(44)38-23-10-8-20(9-11-23)25-17-27(43-28(25)29(35)36-19-37-43)21-12-14-41(15-13-21)32(46)39(2)3/h5-11,16-19,21H,4,12-15H2,1-3H3,(H,38,44)(H2,35,36,37)
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US Patent


Assay Description
The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolved in DMSO were ...


US Patent US10442810 (2019)


BindingDB Entry DOI: 10.7270/Q2NG4T17
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM397011
PNG
(US10442810, Example 73 | US9981975, Example 73)
Show SMILES CCn1cc(C(=O)Nc2ccc(cc2)-c2cc(C3CCN(CC3)C(=O)C(C)C)n3ncnc(N)c23)c(=O)n(-c2cccc(F)c2)c1=O
Show InChI InChI=1S/C34H35FN8O4/c1-4-40-18-27(33(46)42(34(40)47)25-7-5-6-23(35)16-25)31(44)39-24-10-8-21(9-11-24)26-17-28(43-29(26)30(36)37-19-38-43)22-12-14-41(15-13-22)32(45)20(2)3/h5-11,16-20,22H,4,12-15H2,1-3H3,(H,39,44)(H2,36,37,38)
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US Patent


Assay Description
The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolved in DMSO were ...


US Patent US10442810 (2019)


BindingDB Entry DOI: 10.7270/Q2NG4T17
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM397013
PNG
(US10442810, Example 75 | US9981975, Example 75)
Show SMILES CC(C)C(=O)N1CCC(CC1)c1cc(-c2ccc(NC(=O)c3cn(C(C)C)c(=O)n(-c4ccccc4)c3=O)cc2F)c2c(N)ncnn12
Show InChI InChI=1S/C35H37FN8O4/c1-20(2)33(46)41-14-12-22(13-15-41)29-17-26(30-31(37)38-19-39-44(29)30)25-11-10-23(16-28(25)36)40-32(45)27-18-42(21(3)4)35(48)43(34(27)47)24-8-6-5-7-9-24/h5-11,16-22H,12-15H2,1-4H3,(H,40,45)(H2,37,38,39)
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Assay Description
The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolved in DMSO were ...


US Patent US10442810 (2019)


BindingDB Entry DOI: 10.7270/Q2NG4T17
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))
BDBM397012
PNG
(US10442810, Example 74 | US9981975, Example 74)
Show SMILES CC(C)C(=O)N1CCC(CC1)c1cc(-c2ccc(NC(=O)c3cc4C(=O)CCCc4n(-c4ccccc4)c3=O)cc2)c2c(N)ncnn12
Show InChI InChI=1S/C37H37N7O4/c1-22(2)36(47)42-17-15-24(16-18-42)31-20-27(33-34(38)39-21-40-44(31)33)23-11-13-25(14-12-23)41-35(46)29-19-28-30(9-6-10-32(28)45)43(37(29)48)26-7-4-3-5-8-26/h3-5,7-8,11-14,19-22,24H,6,9-10,15-18H2,1-2H3,(H,41,46)(H2,38,39,40)
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US Patent


Assay Description
The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolved in DMSO were ...


US Patent US10442810 (2019)


BindingDB Entry DOI: 10.7270/Q2NG4T17
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))
BDBM397019
PNG
(US10442810, Example 81 | US9981975, Example 81)
Show SMILES CC(C)n1cc(C(=O)Nc2ccc(cc2)-c2cc(C3CCN(CC(=O)N(C)C)CC3)n3ncnc(N)c23)c(=O)n(-c2ccccc2)c1=O
Show InChI InChI=1S/C35H39N9O4/c1-22(2)42-19-28(34(47)43(35(42)48)26-8-6-5-7-9-26)33(46)39-25-12-10-23(11-13-25)27-18-29(44-31(27)32(36)37-21-38-44)24-14-16-41(17-15-24)20-30(45)40(3)4/h5-13,18-19,21-22,24H,14-17,20H2,1-4H3,(H,39,46)(H2,36,37,38)
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Assay Description
The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolved in DMSO were ...


US Patent US10442810 (2019)


BindingDB Entry DOI: 10.7270/Q2NG4T17
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM397025
PNG
(US10442810, Example 87 | US9981975, Example 87)
Show SMILES CC(C)C(=O)N1CCC(CC1)c1cc(-c2ccc(NC(=O)c3cn(C(C)C)c(=O)n(-c4cnn(C)c4)c3=O)cc2)c2c(N)ncnn12
Show InChI InChI=1S/C33H38N10O4/c1-19(2)31(45)40-12-10-22(11-13-40)27-14-25(28-29(34)35-18-37-43(27)28)21-6-8-23(9-7-21)38-30(44)26-17-41(20(3)4)33(47)42(32(26)46)24-15-36-39(5)16-24/h6-9,14-20,22H,10-13H2,1-5H3,(H,38,44)(H2,34,35,37)
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US Patent


Assay Description
The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolved in DMSO were ...


US Patent US10442810 (2019)


BindingDB Entry DOI: 10.7270/Q2NG4T17
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))
BDBM397025
PNG
(US10442810, Example 87 | US9981975, Example 87)
Show SMILES CC(C)C(=O)N1CCC(CC1)c1cc(-c2ccc(NC(=O)c3cn(C(C)C)c(=O)n(-c4cnn(C)c4)c3=O)cc2)c2c(N)ncnn12
Show InChI InChI=1S/C33H38N10O4/c1-19(2)31(45)40-12-10-22(11-13-40)27-14-25(28-29(34)35-18-37-43(27)28)21-6-8-23(9-7-21)38-30(44)26-17-41(20(3)4)33(47)42(32(26)46)24-15-36-39(5)16-24/h6-9,14-20,22H,10-13H2,1-5H3,(H,38,44)(H2,34,35,37)
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Assay Description
The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolved in DMSO were ...


US Patent US10442810 (2019)


BindingDB Entry DOI: 10.7270/Q2NG4T17
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM397031
PNG
(US10442810, Example 95 | US9981975, Example 95)
Show SMILES CC(C)n1cc(C(=O)Nc2ccc(cc2)-c2cc(CN3CCOCC3)n3ncnc(N)c23)c(=O)n(-c2ccccc2)c1=O
Show InChI InChI=1S/C31H32N8O4/c1-20(2)37-18-26(30(41)38(31(37)42)23-6-4-3-5-7-23)29(40)35-22-10-8-21(9-11-22)25-16-24(17-36-12-14-43-15-13-36)39-27(25)28(32)33-19-34-39/h3-11,16,18-20H,12-15,17H2,1-2H3,(H,35,40)(H2,32,33,34)
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Assay Description
The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolved in DMSO were ...


US Patent US10442810 (2019)


BindingDB Entry DOI: 10.7270/Q2NG4T17
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM397039
PNG
(US10442810, Example 103 | US9981975, Example 103)
Show SMILES CC(C)C(=O)N1CCC(CC1)c1cc(-c2ccc(NC(=O)c3cc(-c4cscn4)c(C)n(-c4cncc(F)c4)c3=O)cc2)c2c(N)ncnn12
Show InChI InChI=1S/C36H34FN9O3S/c1-20(2)35(48)44-10-8-23(9-11-44)31-14-28(32-33(38)40-18-42-46(31)32)22-4-6-25(7-5-22)43-34(47)29-13-27(30-17-50-19-41-30)21(3)45(36(29)49)26-12-24(37)15-39-16-26/h4-7,12-20,23H,8-11H2,1-3H3,(H,43,47)(H2,38,40,42)
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Incyte Corporation

US Patent


Assay Description
The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolved in DMSO were ...


US Patent US10442810 (2019)


BindingDB Entry DOI: 10.7270/Q2NG4T17
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))
BDBM397042
PNG
(US10442810, Example 106 | US9981975, Example 106)
Show SMILES CC(C)C(=O)N1CCC(CC1)c1cc(-c2ccc(NC(=O)c3cc(C)c(-c4cccnc4)n(-c4ccccc4)c3=O)cc2)c2c(N)ncnn12
Show InChI InChI=1S/C39H38N8O3/c1-24(2)38(49)45-18-15-27(16-19-45)33-21-31(35-36(40)42-23-43-47(33)35)26-11-13-29(14-12-26)44-37(48)32-20-25(3)34(28-8-7-17-41-22-28)46(39(32)50)30-9-5-4-6-10-30/h4-14,17,20-24,27H,15-16,18-19H2,1-3H3,(H,44,48)(H2,40,42,43)
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n/an/a<5n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolved in DMSO were ...


US Patent US10442810 (2019)


BindingDB Entry DOI: 10.7270/Q2NG4T17
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM397045
PNG
(US10442810, Example 109 | US9981975, Example 109)
Show SMILES CN1CCC(CC1)c1cc(-c2ccc(NC(=O)c3cc(c(C)n(-c4ccccc4)c3=O)-c3ncccn3)cc2)c2c(N)ncnn12
Show InChI InChI=1S/C35H33N9O2/c1-22-27(33-37-15-6-16-38-33)19-29(35(46)43(22)26-7-4-3-5-8-26)34(45)41-25-11-9-23(10-12-25)28-20-30(24-13-17-42(2)18-14-24)44-31(28)32(36)39-21-40-44/h3-12,15-16,19-21,24H,13-14,17-18H2,1-2H3,(H,41,45)(H2,36,39,40)
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US Patent


Assay Description
The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolved in DMSO were ...


US Patent US10442810 (2019)


BindingDB Entry DOI: 10.7270/Q2NG4T17
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM397047
PNG
(US10442810, Example 111 | US9981975, Example 111)
Show SMILES CC(C)C(=O)N1CCC(CC1)c1cc(-c2ccc(NC(=O)c3cc(C#N)c(C)n(-c4ccccc4)c3=O)cc2)c2c(N)ncnn12
Show InChI InChI=1S/C35H34N8O3/c1-21(2)34(45)41-15-13-24(14-16-41)30-18-28(31-32(37)38-20-39-43(30)31)23-9-11-26(12-10-23)40-33(44)29-17-25(19-36)22(3)42(35(29)46)27-7-5-4-6-8-27/h4-12,17-18,20-21,24H,13-16H2,1-3H3,(H,40,44)(H2,37,38,39)
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US Patent


Assay Description
The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolved in DMSO were ...


US Patent US10442810 (2019)


BindingDB Entry DOI: 10.7270/Q2NG4T17
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM397055
PNG
(US10442810, Example 118 | US9981975, Example 118)
Show SMILES CC(C)C(=O)N1CCC(CC1)c1cc(-c2ccc(NC(=O)c3cc(Br)c(C)n(-c4ccccn4)c3=O)cc2)c2c(N)ncnn12
Show InChI InChI=1S/C33H33BrN8O3/c1-19(2)32(44)40-14-11-22(12-15-40)27-17-24(29-30(35)37-18-38-42(27)29)21-7-9-23(10-8-21)39-31(43)25-16-26(34)20(3)41(33(25)45)28-6-4-5-13-36-28/h4-10,13,16-19,22H,11-12,14-15H2,1-3H3,(H,39,43)(H2,35,37,38)
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US Patent


Assay Description
The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolved in DMSO were ...


US Patent US10442810 (2019)


BindingDB Entry DOI: 10.7270/Q2NG4T17
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))
BDBM397056
PNG
(US10442810, Example 119 | US9981975, Example 119)
Show SMILES CC(C)C(=O)N1CCC(CC1)c1cc(-c2ccc(NC(=O)c3cn(C4CC4)c(C)c(-c4ncco4)c3=O)cc2)c2c(N)ncnn12
Show InChI InChI=1S/C34H36N8O4/c1-19(2)34(45)40-13-10-22(11-14-40)27-16-25(29-31(35)37-18-38-42(27)29)21-4-6-23(7-5-21)39-32(44)26-17-41(24-8-9-24)20(3)28(30(26)43)33-36-12-15-46-33/h4-7,12,15-19,22,24H,8-11,13-14H2,1-3H3,(H,39,44)(H2,35,37,38)
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US Patent


Assay Description
The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolved in DMSO were ...


US Patent US10442810 (2019)


BindingDB Entry DOI: 10.7270/Q2NG4T17
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))
BDBM397057
PNG
(US10442810, Example 120 | US9981975, Example 120)
Show SMILES CC(C)C(=O)N1CCC(CC1)c1cc(-c2ccc(NC(=O)c3cc(cn(-c4ccccc4)c3=O)C#C[C@H](C)O)cc2)c2c(N)ncnn12
Show InChI InChI=1S/C37H37N7O4/c1-23(2)36(47)42-17-15-27(16-18-42)32-20-30(33-34(38)39-22-40-44(32)33)26-11-13-28(14-12-26)41-35(46)31-19-25(10-9-24(3)45)21-43(37(31)48)29-7-5-4-6-8-29/h4-8,11-14,19-24,27,45H,15-18H2,1-3H3,(H,41,46)(H2,38,39,40)/t24-/m0/s1
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Assay Description
The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolved in DMSO were ...


US Patent US10442810 (2019)


BindingDB Entry DOI: 10.7270/Q2NG4T17
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))
BDBM397058
PNG
(US10442810, Example 121 | US9981975, Example 121)
Show SMILES CC(C)C(=O)N1CCC(CC1)c1cc(-c2ccc(NC(=O)c3cc(C)c(C)n(-c4cncc(F)c4)c3=O)cc2)c2c(N)ncnn12
Show InChI InChI=1S/C34H35FN8O3/c1-19(2)33(45)41-11-9-23(10-12-41)29-15-27(30-31(36)38-18-39-43(29)30)22-5-7-25(8-6-22)40-32(44)28-13-20(3)21(4)42(34(28)46)26-14-24(35)16-37-17-26/h5-8,13-19,23H,9-12H2,1-4H3,(H,40,44)(H2,36,38,39)
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US Patent


Assay Description
The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolved in DMSO were ...


US Patent US10442810 (2019)


BindingDB Entry DOI: 10.7270/Q2NG4T17
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))
BDBM397064
PNG
(US10442810, Example 127 | US9981975, Example 127)
Show SMILES CC(C)C(=O)N1CCC(CC1)c1cc(-c2ccc(NC(=O)c3cc(C(F)F)c(C)n(-c4ccccn4)c3=O)cc2)c2c(N)ncnn12
Show InChI InChI=1S/C34H34F2N8O3/c1-19(2)33(46)42-14-11-22(12-15-42)27-17-25(29-31(37)39-18-40-44(27)29)21-7-9-23(10-8-21)41-32(45)26-16-24(30(35)36)20(3)43(34(26)47)28-6-4-5-13-38-28/h4-10,13,16-19,22,30H,11-12,14-15H2,1-3H3,(H,41,45)(H2,37,39,40)
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Assay Description
The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolved in DMSO were ...


US Patent US10442810 (2019)


BindingDB Entry DOI: 10.7270/Q2NG4T17
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM397083
PNG
(US10442810, Example 148 | US9981975, Example 148)
Show SMILES CC(C)C(=O)N1CCC(CC1)c1cc(-c2ccc(NC(=O)c3cn(C(C)C)c(=O)n(-c4cc(C)n(C)n4)c3=O)cc2)c2c(N)ncnn12
Show InChI InChI=1S/C34H40N10O4/c1-19(2)32(46)41-13-11-23(12-14-41)27-16-25(29-30(35)36-18-37-44(27)29)22-7-9-24(10-8-22)38-31(45)26-17-42(20(3)4)34(48)43(33(26)47)28-15-21(5)40(6)39-28/h7-10,15-20,23H,11-14H2,1-6H3,(H,38,45)(H2,35,36,37)
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US Patent


Assay Description
The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolved in DMSO were ...


US Patent US10442810 (2019)


BindingDB Entry DOI: 10.7270/Q2NG4T17
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))
BDBM396952
PNG
(US10442810, Example 14 | US9981975, Example 14)
Show SMILES Nc1ncnn2c(cc(-c3ccc(NC(=O)c4cccn(-c5ccc(F)cc5)c4=O)cc3)c12)C1CCOCC1
Show InChI InChI=1S/C29H25FN6O3/c30-20-5-9-22(10-6-20)35-13-1-2-23(29(35)38)28(37)34-21-7-3-18(4-8-21)24-16-25(19-11-14-39-15-12-19)36-26(24)27(31)32-17-33-36/h1-10,13,16-17,19H,11-12,14-15H2,(H,34,37)(H2,31,32,33)
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Incyte Corporation

US Patent


Assay Description
The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolved in DMSO were ...


US Patent US10442810 (2019)


BindingDB Entry DOI: 10.7270/Q2NG4T17
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))
BDBM396961
PNG
(US10442810, Example 23 | US9981975, Example 23)
Show SMILES CN1CCC(CC1)c1cc(-c2ccc(NC(=O)c3cccn(-c4ccc(F)cc4)c3=O)cc2F)c2c(N)ncnn12
Show InChI InChI=1S/C30H27F2N7O2/c1-37-13-10-18(11-14-37)26-16-24(27-28(33)34-17-35-39(26)27)22-9-6-20(15-25(22)32)36-29(40)23-3-2-12-38(30(23)41)21-7-4-19(31)5-8-21/h2-9,12,15-18H,10-11,13-14H2,1H3,(H,36,40)(H2,33,34,35)
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Incyte Corporation

US Patent


Assay Description
The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolved in DMSO were ...


US Patent US10442810 (2019)


BindingDB Entry DOI: 10.7270/Q2NG4T17
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM396972
PNG
(US10442810, Example 34 | US9981975, Example 34)
Show SMILES Nc1ncnn2c(cc(-c3ccc(NC(=O)c4cccn(-c5ccccc5)c4=O)cc3F)c12)C1CCNCC1
Show InChI InChI=1S/C29H26FN7O2/c30-24-15-19(35-28(38)22-7-4-14-36(29(22)39)20-5-2-1-3-6-20)8-9-21(24)23-16-25(18-10-12-32-13-11-18)37-26(23)27(31)33-17-34-37/h1-9,14-18,32H,10-13H2,(H,35,38)(H2,31,33,34)
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US Patent


Assay Description
The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolved in DMSO were ...


US Patent US10442810 (2019)


BindingDB Entry DOI: 10.7270/Q2NG4T17
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))
BDBM396972
PNG
(US10442810, Example 34 | US9981975, Example 34)
Show SMILES Nc1ncnn2c(cc(-c3ccc(NC(=O)c4cccn(-c5ccccc5)c4=O)cc3F)c12)C1CCNCC1
Show InChI InChI=1S/C29H26FN7O2/c30-24-15-19(35-28(38)22-7-4-14-36(29(22)39)20-5-2-1-3-6-20)8-9-21(24)23-16-25(18-10-12-32-13-11-18)37-26(23)27(31)33-17-34-37/h1-9,14-18,32H,10-13H2,(H,35,38)(H2,31,33,34)
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Incyte Corporation

US Patent


Assay Description
The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolved in DMSO were ...


US Patent US10442810 (2019)


BindingDB Entry DOI: 10.7270/Q2NG4T17
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))
BDBM396973
PNG
(US10442810, Example 35 | US9981975, Example 35)
Show SMILES Nc1ncnn2c(cc(-c3ccc(NC(=O)c4cccn(-c5ccc(F)cc5)c4=O)cc3F)c12)C1CCNCC1
Show InChI InChI=1S/C29H25F2N7O2/c30-18-3-6-20(7-4-18)37-13-1-2-22(29(37)40)28(39)36-19-5-8-21(24(31)14-19)23-15-25(17-9-11-33-12-10-17)38-26(23)27(32)34-16-35-38/h1-8,13-17,33H,9-12H2,(H,36,39)(H2,32,34,35)
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US Patent


Assay Description
The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolved in DMSO were ...


US Patent US10442810 (2019)


BindingDB Entry DOI: 10.7270/Q2NG4T17
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))
BDBM396984
PNG
(US10442810, Example 46 | US9981975, Example 46)
Show SMILES CN(C)C(=O)N1CCC(CC1)c1cc(-c2ccc(NC(=O)c3cccn(-c4ccccc4)c3=O)cc2F)c2c(N)ncnn12
Show InChI InChI=1S/C32H31FN8O3/c1-38(2)32(44)39-15-12-20(13-16-39)27-18-25(28-29(34)35-19-36-41(27)28)23-11-10-21(17-26(23)33)37-30(42)24-9-6-14-40(31(24)43)22-7-4-3-5-8-22/h3-11,14,17-20H,12-13,15-16H2,1-2H3,(H,37,42)(H2,34,35,36)
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Incyte Corporation

US Patent


Assay Description
The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolved in DMSO were ...


US Patent US10442810 (2019)


BindingDB Entry DOI: 10.7270/Q2NG4T17
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))
BDBM396985
PNG
(US10442810, Example 47 | US9981975, Example 47)
Show SMILES CN(C)C(=O)N1CCC(CC1)c1cc(-c2ccc(NC(=O)c3cccn(-c4ccc(F)cc4)c3=O)cc2F)c2c(N)ncnn12
Show InChI InChI=1S/C32H30F2N8O3/c1-39(2)32(45)40-14-11-19(12-15-40)27-17-25(28-29(35)36-18-37-42(27)28)23-10-7-21(16-26(23)34)38-30(43)24-4-3-13-41(31(24)44)22-8-5-20(33)6-9-22/h3-10,13,16-19H,11-12,14-15H2,1-2H3,(H,38,43)(H2,35,36,37)
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Incyte Corporation

US Patent


Assay Description
The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolved in DMSO were ...


US Patent US10442810 (2019)


BindingDB Entry DOI: 10.7270/Q2NG4T17
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))
BDBM396987
PNG
(US10442810, Example 49 | US9981975, Example 49)
Show SMILES COCCN1CCC(CC1)c1cc(-c2ccc(NC(=O)c3cccn(-c4ccc(F)cc4)c3=O)cc2)c2c(N)ncnn12
Show InChI InChI=1S/C32H32FN7O3/c1-43-18-17-38-15-12-22(13-16-38)28-19-27(29-30(34)35-20-36-40(28)29)21-4-8-24(9-5-21)37-31(41)26-3-2-14-39(32(26)42)25-10-6-23(33)7-11-25/h2-11,14,19-20,22H,12-13,15-18H2,1H3,(H,37,41)(H2,34,35,36)
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US Patent


Assay Description
The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolved in DMSO were ...


US Patent US10442810 (2019)


BindingDB Entry DOI: 10.7270/Q2NG4T17
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM396993
PNG
(US10442810, Example 55 | US9981975, Example 55)
Show SMILES Nc1ncnn2c(cc(-c3ccc(NC(=O)c4cccn(-c5ccc(F)cc5)c4=O)cc3F)c12)C1CCN(CCO)CC1
Show InChI InChI=1S/C31H29F2N7O3/c32-20-3-6-22(7-4-20)39-11-1-2-24(31(39)43)30(42)37-21-5-8-23(26(33)16-21)25-17-27(40-28(25)29(34)35-18-36-40)19-9-12-38(13-10-19)14-15-41/h1-8,11,16-19,41H,9-10,12-15H2,(H,37,42)(H2,34,35,36)
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US Patent


Assay Description
The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolved in DMSO were ...


US Patent US10442810 (2019)


BindingDB Entry DOI: 10.7270/Q2NG4T17
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))
BDBM396993
PNG
(US10442810, Example 55 | US9981975, Example 55)
Show SMILES Nc1ncnn2c(cc(-c3ccc(NC(=O)c4cccn(-c5ccc(F)cc5)c4=O)cc3F)c12)C1CCN(CCO)CC1
Show InChI InChI=1S/C31H29F2N7O3/c32-20-3-6-22(7-4-20)39-11-1-2-24(31(39)43)30(42)37-21-5-8-23(26(33)16-21)25-17-27(40-28(25)29(34)35-18-36-40)19-9-12-38(13-10-19)14-15-41/h1-8,11,16-19,41H,9-10,12-15H2,(H,37,42)(H2,34,35,36)
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Assay Description
The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolved in DMSO were ...


US Patent US10442810 (2019)


BindingDB Entry DOI: 10.7270/Q2NG4T17
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM396997
PNG
(US10442810, Example 59 | US9981975, Example 59)
Show SMILES Nc1ncnn2c(cc(-c3ccc(NC(=O)c4cc5C(=O)CCCc5n(-c5ccc(F)cc5)c4=O)cc3)c12)C1CCN(CCO)CC1
Show InChI InChI=1S/C35H34FN7O4/c36-23-6-10-25(11-7-23)42-29-2-1-3-31(45)27(29)18-28(35(42)47)34(46)40-24-8-4-21(5-9-24)26-19-30(43-32(26)33(37)38-20-39-43)22-12-14-41(15-13-22)16-17-44/h4-11,18-20,22,44H,1-3,12-17H2,(H,40,46)(H2,37,38,39)
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US Patent


Assay Description
The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolved in DMSO were ...


US Patent US10442810 (2019)


BindingDB Entry DOI: 10.7270/Q2NG4T17
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM396998
PNG
(US10442810, Example 60 | US9981975, Example 60)
Show SMILES Nc1ncnn2c(cc(-c3ccc(NC(=O)c4cc5C(=O)CCCc5n(-c5ccc(F)cc5)c4=O)cc3F)c12)C1CCN(CCO)CC1
Show InChI InChI=1S/C35H33F2N7O4/c36-21-4-7-23(8-5-21)43-29-2-1-3-31(46)26(29)17-27(35(43)48)34(47)41-22-6-9-24(28(37)16-22)25-18-30(44-32(25)33(38)39-19-40-44)20-10-12-42(13-11-20)14-15-45/h4-9,16-20,45H,1-3,10-15H2,(H,41,47)(H2,38,39,40)
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Incyte Corporation

US Patent


Assay Description
The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolved in DMSO were ...


US Patent US10442810 (2019)


BindingDB Entry DOI: 10.7270/Q2NG4T17
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM397007
PNG
(US10442810, Example 69 | US9981975, Example 69)
Show SMILES CCN(C)C(=O)N1CCC(CC1)c1cc(-c2ccc(NC(=O)c3cn(C(C)C)c(=O)n(-c4ccccc4F)c3=O)cc2)c2c(N)ncnn12
Show InChI InChI=1S/C35H38FN9O4/c1-5-41(4)34(48)42-16-14-23(15-17-42)29-18-25(30-31(37)38-20-39-45(29)30)22-10-12-24(13-11-22)40-32(46)26-19-43(21(2)3)35(49)44(33(26)47)28-9-7-6-8-27(28)36/h6-13,18-21,23H,5,14-17H2,1-4H3,(H,40,46)(H2,37,38,39)
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US Patent


Assay Description
The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolved in DMSO were ...


US Patent US10442810 (2019)


BindingDB Entry DOI: 10.7270/Q2NG4T17
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM397012
PNG
(US10442810, Example 74 | US9981975, Example 74)
Show SMILES CC(C)C(=O)N1CCC(CC1)c1cc(-c2ccc(NC(=O)c3cc4C(=O)CCCc4n(-c4ccccc4)c3=O)cc2)c2c(N)ncnn12
Show InChI InChI=1S/C37H37N7O4/c1-22(2)36(47)42-17-15-24(16-18-42)31-20-27(33-34(38)39-21-40-44(31)33)23-11-13-25(14-12-23)41-35(46)29-19-28-30(9-6-10-32(28)45)43(37(29)48)26-7-4-3-5-8-26/h3-5,7-8,11-14,19-22,24H,6,9-10,15-18H2,1-2H3,(H,41,46)(H2,38,39,40)
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Assay Description
The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolved in DMSO were ...


US Patent US10442810 (2019)


BindingDB Entry DOI: 10.7270/Q2NG4T17
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM397017
PNG
(US10442810, Example 79 | US9981975, Example 79)
Show SMILES CCn1cc(C(=O)Nc2ccc(cc2)-c2cc(C3CCN(CC3)C(=O)[C@@H](C)O)n3ncnc(N)c23)c(=O)n(-c2ccc(F)cc2)c1=O
Show InChI InChI=1S/C33H33FN8O5/c1-3-39-17-26(32(46)41(33(39)47)24-10-6-22(34)7-11-24)30(44)38-23-8-4-20(5-9-23)25-16-27(42-28(25)29(35)36-18-37-42)21-12-14-40(15-13-21)31(45)19(2)43/h4-11,16-19,21,43H,3,12-15H2,1-2H3,(H,38,44)(H2,35,36,37)/t19-/m1/s1
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US Patent


Assay Description
The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolved in DMSO were ...


US Patent US10442810 (2019)


BindingDB Entry DOI: 10.7270/Q2NG4T17
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM397020
PNG
(US10442810, Example 82 | US9981975, Example 82)
Show SMILES CC(C)n1cc(C(=O)Nc2ccc(cc2)-c2cc(C3CCN(CC3)C3CCN(C)C3=O)n3ncnc(N)c23)c(=O)n(-c2ccccc2)c1=O
Show InChI InChI=1S/C36H39N9O4/c1-22(2)43-20-28(34(47)44(36(43)49)26-7-5-4-6-8-26)33(46)40-25-11-9-23(10-12-25)27-19-30(45-31(27)32(37)38-21-39-45)24-13-17-42(18-14-24)29-15-16-41(3)35(29)48/h4-12,19-22,24,29H,13-18H2,1-3H3,(H,40,46)(H2,37,38,39)
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US Patent


Assay Description
The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolved in DMSO were ...


US Patent US10442810 (2019)


BindingDB Entry DOI: 10.7270/Q2NG4T17
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))
BDBM397026
PNG
(US10442810, Example 88 | US9981975, Example 88)
Show SMILES CC(C)C(=O)N1CCC(CC1)c1cc(-c2ccc(NC(=O)c3cn(C(C)C)c(=O)n(-c4ccn(C)n4)c3=O)cc2)c2c(N)ncnn12
Show InChI InChI=1S/C33H38N10O4/c1-19(2)31(45)40-14-10-22(11-15-40)26-16-24(28-29(34)35-18-36-43(26)28)21-6-8-23(9-7-21)37-30(44)25-17-41(20(3)4)33(47)42(32(25)46)27-12-13-39(5)38-27/h6-9,12-13,16-20,22H,10-11,14-15H2,1-5H3,(H,37,44)(H2,34,35,36)
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Assay Description
The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolved in DMSO were ...


US Patent US10442810 (2019)


BindingDB Entry DOI: 10.7270/Q2NG4T17
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM397044
PNG
(US10442810, Example 108 | US9981975, Example 108)
Show SMILES CC(C)C(=O)N1CCC(CC1)c1cc(-c2ccc(NC(=O)c3cc(c(C)n(-c4ccccc4)c3=O)-c3ncccn3)cc2)c2c(N)ncnn12
Show InChI InChI=1S/C38H37N9O3/c1-23(2)37(49)45-18-14-26(15-19-45)32-21-30(33-34(39)42-22-43-47(32)33)25-10-12-27(13-11-25)44-36(48)31-20-29(35-40-16-7-17-41-35)24(3)46(38(31)50)28-8-5-4-6-9-28/h4-13,16-17,20-23,26H,14-15,18-19H2,1-3H3,(H,44,48)(H2,39,42,43)
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Incyte Corporation

US Patent


Assay Description
The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolved in DMSO were ...


US Patent US10442810 (2019)


BindingDB Entry DOI: 10.7270/Q2NG4T17
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM415946
PNG
(US10442810, Example 112)
Show SMILES CC(C)C(=O)N1CCC(CC1)c1cc(-c2ccc(NC(=O)c3cc(C(C)=O)c(C)n(-c4ccccc4)c3=O)cc2)c2c(N)ncnn12
Show InChI InChI=1S/C36H37N7O4/c1-21(2)35(46)41-16-14-25(15-17-41)31-19-29(32-33(37)38-20-39-43(31)32)24-10-12-26(13-11-24)40-34(45)30-18-28(23(4)44)22(3)42(36(30)47)27-8-6-5-7-9-27/h5-13,18-21,25H,14-17H2,1-4H3,(H,40,45)(H2,37,38,39)
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Incyte Corporation

US Patent


Assay Description
The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolved in DMSO were ...


US Patent US10442810 (2019)


BindingDB Entry DOI: 10.7270/Q2NG4T17
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM397051
PNG
(US10442810, Example 114 | US9981975, Example 114)
Show SMILES CC(C)C(=O)N1CCC(CC1)c1cc(-c2ccc(NC(=O)c3cc4C(=O)CC(C)(C)Cc4n(-c4cccnc4)c3=O)cc2)c2c(N)ncnn12
Show InChI InChI=1S/C38H40N8O4/c1-22(2)36(49)44-14-11-24(12-15-44)30-17-27(33-34(39)41-21-42-46(30)33)23-7-9-25(10-8-23)43-35(48)29-16-28-31(18-38(3,4)19-32(28)47)45(37(29)50)26-6-5-13-40-20-26/h5-10,13,16-17,20-22,24H,11-12,14-15,18-19H2,1-4H3,(H,43,48)(H2,39,41,42)
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Incyte Corporation

US Patent


Assay Description
The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolved in DMSO were ...


US Patent US10442810 (2019)


BindingDB Entry DOI: 10.7270/Q2NG4T17
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))
BDBM397053
PNG
(US10442810, Example 116 | US9981975, Example 116)
Show SMILES CC(C)C(=O)N1CCC(CC1)c1cc(-c2ccc(NC(=O)c3cnc(-c4cccnc4)n(-c4ccccc4)c3=O)cc2)c2c(N)ncnn12
Show InChI InChI=1S/C37H35N9O3/c1-23(2)36(48)44-17-14-25(15-18-44)31-19-29(32-33(38)41-22-42-46(31)32)24-10-12-27(13-11-24)43-35(47)30-21-40-34(26-7-6-16-39-20-26)45(37(30)49)28-8-4-3-5-9-28/h3-13,16,19-23,25H,14-15,17-18H2,1-2H3,(H,43,47)(H2,38,41,42)
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Incyte Corporation

US Patent


Assay Description
The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolved in DMSO were ...


US Patent US10442810 (2019)


BindingDB Entry DOI: 10.7270/Q2NG4T17
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM397056
PNG
(US10442810, Example 119 | US9981975, Example 119)
Show SMILES CC(C)C(=O)N1CCC(CC1)c1cc(-c2ccc(NC(=O)c3cn(C4CC4)c(C)c(-c4ncco4)c3=O)cc2)c2c(N)ncnn12
Show InChI InChI=1S/C34H36N8O4/c1-19(2)34(45)40-13-10-22(11-14-40)27-16-25(29-31(35)37-18-38-42(27)29)21-4-6-23(7-5-21)39-32(44)26-17-41(24-8-9-24)20(3)28(30(26)43)33-36-12-15-46-33/h4-7,12,15-19,22,24H,8-11,13-14H2,1-3H3,(H,39,44)(H2,35,37,38)
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US Patent


Assay Description
The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolved in DMSO were ...


US Patent US10442810 (2019)


BindingDB Entry DOI: 10.7270/Q2NG4T17
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM397058
PNG
(US10442810, Example 121 | US9981975, Example 121)
Show SMILES CC(C)C(=O)N1CCC(CC1)c1cc(-c2ccc(NC(=O)c3cc(C)c(C)n(-c4cncc(F)c4)c3=O)cc2)c2c(N)ncnn12
Show InChI InChI=1S/C34H35FN8O3/c1-19(2)33(45)41-11-9-23(10-12-41)29-15-27(30-31(36)38-18-39-43(29)30)22-5-7-25(8-6-22)40-32(44)28-13-20(3)21(4)42(34(28)46)26-14-24(35)16-37-17-26/h5-8,13-19,23H,9-12H2,1-4H3,(H,40,44)(H2,36,38,39)
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US Patent


Assay Description
The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolved in DMSO were ...


US Patent US10442810 (2019)


BindingDB Entry DOI: 10.7270/Q2NG4T17
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM397064
PNG
(US10442810, Example 127 | US9981975, Example 127)
Show SMILES CC(C)C(=O)N1CCC(CC1)c1cc(-c2ccc(NC(=O)c3cc(C(F)F)c(C)n(-c4ccccn4)c3=O)cc2)c2c(N)ncnn12
Show InChI InChI=1S/C34H34F2N8O3/c1-19(2)33(46)42-14-11-22(12-15-42)27-17-25(29-31(37)39-18-40-44(27)29)21-7-9-23(10-8-21)41-32(45)26-16-24(30(35)36)20(3)43(34(26)47)28-6-4-5-13-38-28/h4-10,13,16-19,22,30H,11-12,14-15H2,1-3H3,(H,41,45)(H2,37,39,40)
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Incyte Corporation

US Patent


Assay Description
The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolved in DMSO were ...


US Patent US10442810 (2019)


BindingDB Entry DOI: 10.7270/Q2NG4T17
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM397067
PNG
(US10442810, Example 130 | US9981975, Example 130)
Show SMILES CC(C)C(=O)N1CCC(CC1)c1cc(-c2ccc(NC(=O)c3cc(Br)c(C)n(-c4cccnc4)c3=O)cc2)c2c(N)ncnn12
Show InChI InChI=1S/C33H33BrN8O3/c1-19(2)32(44)40-13-10-22(11-14-40)28-16-25(29-30(35)37-18-38-42(28)29)21-6-8-23(9-7-21)39-31(43)26-15-27(34)20(3)41(33(26)45)24-5-4-12-36-17-24/h4-9,12,15-19,22H,10-11,13-14H2,1-3H3,(H,39,43)(H2,35,37,38)
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Incyte Corporation

US Patent


Assay Description
The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolved in DMSO were ...


US Patent US10442810 (2019)


BindingDB Entry DOI: 10.7270/Q2NG4T17
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))
BDBM397069
PNG
(US10442810, Example 132 | US9981975, Example 132)
Show SMILES CC(C)C(=O)N1CCC(CC1)c1cc(-c2ccc(NC(=O)c3cc(C)c(C)n(-c4cccnc4)c3=O)cc2)c2c(N)ncnn12
Show InChI InChI=1S/C34H36N8O3/c1-20(2)33(44)40-14-11-24(12-15-40)29-17-27(30-31(35)37-19-38-42(29)30)23-7-9-25(10-8-23)39-32(43)28-16-21(3)22(4)41(34(28)45)26-6-5-13-36-18-26/h5-10,13,16-20,24H,11-12,14-15H2,1-4H3,(H,39,43)(H2,35,37,38)
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US Patent


Assay Description
The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolved in DMSO were ...


US Patent US10442810 (2019)


BindingDB Entry DOI: 10.7270/Q2NG4T17
More data for this
Ligand-Target Pair
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* indicates data uncertainty>20%