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Patent code US10450296

Compile Data Set for Download or QSAR

Found 510 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM376707
PNG
(N-(4-((1R,3S,5S)-3-Amino-5-methylcyclohexyl)pyridi...)
Show SMILES C[C@@H]1C[C@H](N)C[C@@H](C1)c1ccncc1NC(=O)c1ccc(F)c2cc(cnc12)N1CCC(F)(F)CC1
Show InChI InChI=1S/C27H30F3N5O/c1-16-10-17(12-18(31)11-16)20-4-7-32-15-24(20)34-26(36)21-2-3-23(28)22-13-19(14-33-25(21)22)35-8-5-27(29,30)6-9-35/h2-4,7,13-18H,5-6,8-12,31H2,1H3,(H,34,36)/t16-,17+,18-/m0/s1
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US Patent


Assay Description
Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US10450296 (2019)


BindingDB Entry DOI: 10.7270/Q2MP55J7
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))
BDBM376721
PNG
(N-(4-((1R,3S,5S)-3-Amino-5-methylcyclohexyl)pyridi...)
Show SMILES CC(C)[C@H](C)Nc1cnc2c(ccc(F)c2c1)C(=O)Nc1cnccc1[C@@H]1C[C@H](C)C[C@H](N)C1
Show InChI InChI=1S/C27H34FN5O/c1-15(2)17(4)32-20-12-23-24(28)6-5-22(26(23)31-13-20)27(34)33-25-14-30-8-7-21(25)18-9-16(3)10-19(29)11-18/h5-8,12-19,32H,9-11,29H2,1-4H3,(H,33,34)/t16-,17-,18+,19-/m0/s1
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US Patent


Assay Description
Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US10450296 (2019)


BindingDB Entry DOI: 10.7270/Q2MP55J7
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM376726
PNG
(N-(4-((1R,3S,5S)-3-Amino-5-methylcyclohexyl)pyridi...)
Show SMILES C[C@@H]1C[C@H](N)C[C@@H](C1)c1ccncc1NC(=O)c1ccc(F)c2cc(cnc12)N1CCCCC1C(F)F
Show InChI InChI=1S/C28H32F3N5O/c1-16-10-17(12-18(32)11-16)20-7-8-33-15-24(20)35-28(37)21-5-6-23(29)22-13-19(14-34-26(21)22)36-9-3-2-4-25(36)27(30)31/h5-8,13-18,25,27H,2-4,9-12,32H2,1H3,(H,35,37)/t16-,17+,18-,25?/m0/s1
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US Patent


Assay Description
Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US10450296 (2019)


BindingDB Entry DOI: 10.7270/Q2MP55J7
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))
BDBM376732
PNG
(N-(4-((1R,3S,5S)-3-Amino-5-methylcyclohexyl)pyridi...)
Show SMILES C[C@@H]1C[C@H](N)C[C@@H](C1)c1ccncc1NC(=O)c1ccc(F)c2cc(cnc12)-c1cnn(C)c1
Show InChI InChI=1S/C26H27FN6O/c1-15-7-16(9-19(28)8-15)20-5-6-29-13-24(20)32-26(34)21-3-4-23(27)22-10-17(11-30-25(21)22)18-12-31-33(2)14-18/h3-6,10-16,19H,7-9,28H2,1-2H3,(H,32,34)/t15-,16+,19-/m0/s1
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US Patent


Assay Description
Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US10450296 (2019)


BindingDB Entry DOI: 10.7270/Q2MP55J7
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))
BDBM376733
PNG
(N-(4-((1R,3S,5S)-3-amino-5-methylcyclohexyl)pyridi...)
Show SMILES C[C@@H]1C[C@H](N)C[C@@H](C1)c1ccncc1NC(=O)c1ccc(F)c2cc(cnc12)-c1c[nH]nc1C
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US Patent


Assay Description
Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US10450296 (2019)


BindingDB Entry DOI: 10.7270/Q2MP55J7
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))
BDBM376735
PNG
(N-(4-((1R,3S,5S)-3-Amino-5-methylcyclohexyl)pyridi...)
Show SMILES C[C@@H]1C[C@H](N)C[C@@H](C1)c1ccncc1NC(=O)c1cccc2cc(cnc12)N1CCOC[C@H]1C
Show InChI InChI=1S/C27H33N5O2/c1-17-10-20(12-21(28)11-17)23-6-7-29-15-25(23)31-27(33)24-5-3-4-19-13-22(14-30-26(19)24)32-8-9-34-16-18(32)2/h3-7,13-15,17-18,20-21H,8-12,16,28H2,1-2H3,(H,31,33)/t17-,18+,20+,21-/m0/s1
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US Patent


Assay Description
Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US10450296 (2019)


BindingDB Entry DOI: 10.7270/Q2MP55J7
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))
BDBM376740
PNG
(N-(4-((1R,3S,5S)-3-Amino-5-methylcyclohexyl)pyridi...)
Show SMILES C[C@@H]1C[C@H](N)C[C@@H](C1)c1ccncc1NC(=O)c1cccc2cc(cnc12)N(C)CC(F)F
Show InChI InChI=1S/C25H29F2N5O/c1-15-8-17(10-18(28)9-15)20-6-7-29-13-22(20)31-25(33)21-5-3-4-16-11-19(12-30-24(16)21)32(2)14-23(26)27/h3-7,11-13,15,17-18,23H,8-10,14,28H2,1-2H3,(H,31,33)/t15-,17+,18-/m0/s1
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US Patent


Assay Description
Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US10450296 (2019)


BindingDB Entry DOI: 10.7270/Q2MP55J7
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))
BDBM376781
PNG
(N-(4-((1R,3S,5S)-3-Amino-5-methylcyclohexyl)pyridi...)
Show SMILES C[C@@H]1C[C@H](N)C[C@@H](C1)c1ccncc1NC(=O)c1ccc(F)c2cc(cnc12)N1CCN(C)C(=O)[C@@H]1C
Show InChI InChI=1S/C28H33FN6O2/c1-16-10-18(12-19(30)11-16)21-6-7-31-15-25(21)33-27(36)22-4-5-24(29)23-13-20(14-32-26(22)23)35-9-8-34(3)28(37)17(35)2/h4-7,13-19H,8-12,30H2,1-3H3,(H,33,36)/t16-,17-,18+,19-/m0/s1
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US Patent


Assay Description
Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US10450296 (2019)


BindingDB Entry DOI: 10.7270/Q2MP55J7
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))
BDBM376786
PNG
(N-(4-((1R,3S,5S)-3-Amino-5-methylcyclohexyl)pyridi...)
Show SMILES CC(C)CN1CCN(CC1=O)c1cnc2c(ccc(F)c2c1)C(=O)Nc1cnccc1[C@@H]1C[C@H](C)C[C@H](N)C1
Show InChI InChI=1S/C30H37FN6O2/c1-18(2)16-37-9-8-36(17-28(37)38)22-13-25-26(31)5-4-24(29(25)34-14-22)30(39)35-27-15-33-7-6-23(27)20-10-19(3)11-21(32)12-20/h4-7,13-15,18-21H,8-12,16-17,32H2,1-3H3,(H,35,39)/t19-,20+,21-/m0/s1
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US Patent


Assay Description
Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US10450296 (2019)


BindingDB Entry DOI: 10.7270/Q2MP55J7
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM376791
PNG
(N-(4-((1R,3S,5S)-3-Amino-5-methylcyclohexyl)pyridi...)
Show SMILES CCOC1CN(C1)c1cnc2c(ccc(F)c2c1)C(=O)Nc1cnccc1[C@@H]1C[C@H](C)C[C@H](N)C1
Show InChI InChI=1S/C27H32FN5O2/c1-3-35-20-14-33(15-20)19-11-23-24(28)5-4-22(26(23)31-12-19)27(34)32-25-13-30-7-6-21(25)17-8-16(2)9-18(29)10-17/h4-7,11-13,16-18,20H,3,8-10,14-15,29H2,1-2H3,(H,32,34)/t16-,17+,18-/m0/s1
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Assay Description
Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US10450296 (2019)


BindingDB Entry DOI: 10.7270/Q2MP55J7
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM376792
PNG
(N-(4-((1R,3S,5S)-3-Amino-5-methylcyclohexyl)pyridi...)
Show SMILES C[C@@H]1C[C@H](N)C[C@@H](C1)c1ccncc1NC(=O)c1ccc(F)c2cc(cnc12)N1CC[C@H]1CO
Show InChI InChI=1S/C26H30FN5O2/c1-15-8-16(10-17(28)9-15)20-4-6-29-13-24(20)31-26(34)21-2-3-23(27)22-11-19(12-30-25(21)22)32-7-5-18(32)14-33/h2-4,6,11-13,15-18,33H,5,7-10,14,28H2,1H3,(H,31,34)/t15-,16+,17-,18-/m0/s1
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Assay Description
Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US10450296 (2019)


BindingDB Entry DOI: 10.7270/Q2MP55J7
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))
BDBM376793
PNG
(N-(4-((1R,3S,5S)-3-Amino-5-methylcyclohexyl)pyridi...)
Show SMILES C[C@@H]1C[C@H](N)C[C@@H](C1)c1ccncc1NC(=O)c1ccc(F)c2cc(cnc12)N1CCCN(C)CC1
Show InChI InChI=1S/C28H35FN6O/c1-18-12-19(14-20(30)13-18)22-6-7-31-17-26(22)33-28(36)23-4-5-25(29)24-15-21(16-32-27(23)24)35-9-3-8-34(2)10-11-35/h4-7,15-20H,3,8-14,30H2,1-2H3,(H,33,36)/t18-,19+,20-/m0/s1
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Assay Description
Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US10450296 (2019)


BindingDB Entry DOI: 10.7270/Q2MP55J7
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM376837
PNG
(Ethyl 4-(8-(4-((1R,3S,5S)-3-amino-5-methylcyclohex...)
Show SMILES CCOC(=O)N1CCN(CC1)c1cnc2c(ccc(F)c2c1)C(=O)Nc1cnccc1[C@@H]1C[C@H](C)C[C@H](N)C1
Show InChI InChI=1S/C29H35FN6O3/c1-3-39-29(38)36-10-8-35(9-11-36)21-15-24-25(30)5-4-23(27(24)33-16-21)28(37)34-26-17-32-7-6-22(26)19-12-18(2)13-20(31)14-19/h4-7,15-20H,3,8-14,31H2,1-2H3,(H,34,37)/t18-,19+,20-/m0/s1
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Assay Description
Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US10450296 (2019)


BindingDB Entry DOI: 10.7270/Q2MP55J7
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))
BDBM376802
PNG
(N-(4-((1R,3S,5S)-3-Amino-5-methylcyclohexyl)pyridi...)
Show SMILES COCCN1CCN(CC1=O)c1cnc2c(ccc(F)c2c1)C(=O)Nc1cnccc1[C@@H]1C[C@H](C)C[C@H](N)C1
Show InChI InChI=1S/C29H35FN6O3/c1-18-11-19(13-20(31)12-18)22-5-6-32-16-26(22)34-29(38)23-3-4-25(30)24-14-21(15-33-28(23)24)36-8-7-35(9-10-39-2)27(37)17-36/h3-6,14-16,18-20H,7-13,17,31H2,1-2H3,(H,34,38)/t18-,19+,20-/m0/s1
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Assay Description
Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US10450296 (2019)


BindingDB Entry DOI: 10.7270/Q2MP55J7
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))
BDBM376804
PNG
(N-(4-((1R,3S,5S)-3-Amino-5-methylcyclohexyl)pyridi...)
Show SMILES C[C@@H]1C[C@H](N)C[C@@H](C1)c1ccncc1NC(=O)c1ccc(F)c2cc(cnc12)N1CCCN(C)C(=O)C1
Show InChI InChI=1S/C28H33FN6O2/c1-17-10-18(12-19(30)11-17)21-6-7-31-15-25(21)33-28(37)22-4-5-24(29)23-13-20(14-32-27(22)23)35-9-3-8-34(2)26(36)16-35/h4-7,13-15,17-19H,3,8-12,16,30H2,1-2H3,(H,33,37)/t17-,18+,19-/m0/s1
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Assay Description
Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US10450296 (2019)


BindingDB Entry DOI: 10.7270/Q2MP55J7
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM376815
PNG
(N-(4-((1R,3S,5S)-3-Amino-5-methylcyclohexyl)pyridi...)
Show SMILES C[C@@H]1C[C@H](N)C[C@@H](C1)c1ccncc1NC(=O)c1ccc(F)c2cc(cnc12)N(C)c1cnccc1C
Show InChI InChI=1S/C29H31FN6O/c1-17-10-19(12-20(31)11-17)22-7-9-32-15-26(22)35-29(37)23-4-5-25(30)24-13-21(14-34-28(23)24)36(3)27-16-33-8-6-18(27)2/h4-9,13-17,19-20H,10-12,31H2,1-3H3,(H,35,37)/t17-,19+,20-/m0/s1
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Assay Description
Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US10450296 (2019)


BindingDB Entry DOI: 10.7270/Q2MP55J7
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM376818
PNG
(N-(4-((1R,3S,5S)-3-Amino-5-methylcyclohexyl)pyridi...)
Show SMILES C[C@@H]1C[C@H](N)C[C@@H](C1)c1ccncc1NC(=O)c1ccc(F)c2cc(cnc12)N(C)c1nccnc1C
Show InChI InChI=1S/C28H30FN7O/c1-16-10-18(12-19(30)11-16)21-6-7-31-15-25(21)35-28(37)22-4-5-24(29)23-13-20(14-34-26(22)23)36(3)27-17(2)32-8-9-33-27/h4-9,13-16,18-19H,10-12,30H2,1-3H3,(H,35,37)/t16-,18+,19-/m0/s1
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Assay Description
Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US10450296 (2019)


BindingDB Entry DOI: 10.7270/Q2MP55J7
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM376819
PNG
(N-(4-((1R,3S,5S)-3-Amino-5-methylcyclohexyl)pyridi...)
Show SMILES COc1ccncc1N(C)c1cnc2c(ccc(F)c2c1)C(=O)Nc1cnccc1[C@@H]1C[C@H](C)C[C@H](N)C1
Show InChI InChI=1S/C29H31FN6O2/c1-17-10-18(12-19(31)11-17)21-6-8-32-15-25(21)35-29(37)22-4-5-24(30)23-13-20(14-34-28(22)23)36(2)26-16-33-9-7-27(26)38-3/h4-9,13-19H,10-12,31H2,1-3H3,(H,35,37)/t17-,18+,19-/m0/s1
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US Patent


Assay Description
Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US10450296 (2019)


BindingDB Entry DOI: 10.7270/Q2MP55J7
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))
BDBM376819
PNG
(N-(4-((1R,3S,5S)-3-Amino-5-methylcyclohexyl)pyridi...)
Show SMILES COc1ccncc1N(C)c1cnc2c(ccc(F)c2c1)C(=O)Nc1cnccc1[C@@H]1C[C@H](C)C[C@H](N)C1
Show InChI InChI=1S/C29H31FN6O2/c1-17-10-18(12-19(31)11-17)21-6-8-32-15-25(21)35-29(37)22-4-5-24(30)23-13-20(14-34-28(22)23)36(2)26-16-33-9-7-27(26)38-3/h4-9,13-19H,10-12,31H2,1-3H3,(H,35,37)/t17-,18+,19-/m0/s1
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US Patent


Assay Description
Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US10450296 (2019)


BindingDB Entry DOI: 10.7270/Q2MP55J7
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))
BDBM376821
PNG
(N-(4-((1R,3S,5S)-3-Amino-5-methylcyclohexyl)pyridi...)
Show SMILES COc1ccccc1N(C)c1cnc2c(ccc(F)c2c1)C(=O)Nc1cnccc1[C@@H]1C[C@H](C)C[C@H](N)C1
Show InChI InChI=1S/C30H32FN5O2/c1-18-12-19(14-20(32)13-18)22-10-11-33-17-26(22)35-30(37)23-8-9-25(31)24-15-21(16-34-29(23)24)36(2)27-6-4-5-7-28(27)38-3/h4-11,15-20H,12-14,32H2,1-3H3,(H,35,37)/t18-,19+,20-/m0/s1
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US Patent


Assay Description
Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US10450296 (2019)


BindingDB Entry DOI: 10.7270/Q2MP55J7
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM376823
PNG
(N-(4-((1R,3S,5S)-3-Amino-5-methylcyclohexyl)pyridi...)
Show SMILES C[C@@H]1C[C@H](N)C[C@@H](C1)c1ccncc1NC(=O)c1ccc(F)c2cc(cnc12)N(C)[C@@H]1CCOC1
Show InChI InChI=1S/C27H32FN5O2/c1-16-9-17(11-18(29)10-16)21-5-7-30-14-25(21)32-27(34)22-3-4-24(28)23-12-20(13-31-26(22)23)33(2)19-6-8-35-15-19/h3-5,7,12-14,16-19H,6,8-11,15,29H2,1-2H3,(H,32,34)/t16-,17+,18-,19+/m0/s1
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US Patent


Assay Description
Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US10450296 (2019)


BindingDB Entry DOI: 10.7270/Q2MP55J7
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM376828
PNG
(N-(4-((1R,3S,5S)-3-Amino-5-methylcyclohexyl)pyridi...)
Show SMILES CO[C@H]1CCN([C@H](C)C1)c1cnc2c(ccc(F)c2c1)C(=O)Nc1cnccc1[C@@H]1C[C@H](C)C[C@H](N)C1
Show InChI InChI=1S/C29H36FN5O2/c1-17-10-19(13-20(31)11-17)23-6-8-32-16-27(23)34-29(36)24-4-5-26(30)25-14-21(15-33-28(24)25)35-9-7-22(37-3)12-18(35)2/h4-6,8,14-20,22H,7,9-13,31H2,1-3H3,(H,34,36)/t17-,18+,19+,20-,22-/m0/s1
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US Patent


Assay Description
Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US10450296 (2019)


BindingDB Entry DOI: 10.7270/Q2MP55J7
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))
BDBM376828
PNG
(N-(4-((1R,3S,5S)-3-Amino-5-methylcyclohexyl)pyridi...)
Show SMILES CO[C@H]1CCN([C@H](C)C1)c1cnc2c(ccc(F)c2c1)C(=O)Nc1cnccc1[C@@H]1C[C@H](C)C[C@H](N)C1
Show InChI InChI=1S/C29H36FN5O2/c1-17-10-19(13-20(31)11-17)23-6-8-32-16-27(23)34-29(36)24-4-5-26(30)25-14-21(15-33-28(24)25)35-9-7-22(37-3)12-18(35)2/h4-6,8,14-20,22H,7,9-13,31H2,1-3H3,(H,34,36)/t17-,18+,19+,20-,22-/m0/s1
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US Patent


Assay Description
Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US10450296 (2019)


BindingDB Entry DOI: 10.7270/Q2MP55J7
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM376745
PNG
(N-(4-((1R,3S,5S)-3-Amino-5-methylcyclohexyl)pyridi...)
Show SMILES C[C@@H]1C[C@H](N)C[C@@H](C1)c1ccncc1NC(=O)c1ccc(F)c2cc(cnc12)N1C2CCC1COC2
Show InChI InChI=1S/C28H32FN5O2/c1-16-8-17(10-18(30)9-16)22-6-7-31-13-26(22)33-28(35)23-4-5-25(29)24-11-21(12-32-27(23)24)34-19-2-3-20(34)15-36-14-19/h4-7,11-13,16-20H,2-3,8-10,14-15,30H2,1H3,(H,33,35)/t16-,17+,18-,19?,20?/m0/s1
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US Patent


Assay Description
Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US10450296 (2019)


BindingDB Entry DOI: 10.7270/Q2MP55J7
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))
BDBM376753
PNG
(N-(4-((1R,3S,5S)-3-Amino-5-methylcyclohexyl)pyridi...)
Show SMILES C[C@@H]1C[C@H](N)C[C@@H](C1)c1ccncc1NC(=O)c1ccc(F)c2cc(cnc12)N1CCN(C[C@@H]1C)S(C)(=O)=O
Show InChI InChI=1S/C28H35FN6O3S/c1-17-10-19(12-20(30)11-17)22-6-7-31-15-26(22)33-28(36)23-4-5-25(29)24-13-21(14-32-27(23)24)35-9-8-34(16-18(35)2)39(3,37)38/h4-7,13-15,17-20H,8-12,16,30H2,1-3H3,(H,33,36)/t17-,18-,19+,20-/m0/s1
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US Patent


Assay Description
Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US10450296 (2019)


BindingDB Entry DOI: 10.7270/Q2MP55J7
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM376754
PNG
(N-(4-((1R,3S,5S)-3-Amino-5-methylcyclohexyl)pyridi...)
Show SMILES C[C@@H]1C[C@H](N)C[C@@H](C1)c1ccncc1NC(=O)c1ccc(F)c2cc(cnc12)N1CCN(C[C@H]1C)S(C)(=O)=O
Show InChI InChI=1S/C28H35FN6O3S/c1-17-10-19(12-20(30)11-17)22-6-7-31-15-26(22)33-28(36)23-4-5-25(29)24-13-21(14-32-27(23)24)35-9-8-34(16-18(35)2)39(3,37)38/h4-7,13-15,17-20H,8-12,16,30H2,1-3H3,(H,33,36)/t17-,18+,19+,20-/m0/s1
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US Patent


Assay Description
Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US10450296 (2019)


BindingDB Entry DOI: 10.7270/Q2MP55J7
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM376758
PNG
((1R,4R)-Methyl 5-(8-(4-((1R,3S,5S)-3-amino-5-methy...)
Show SMILES COC(=O)N1C[C@H]2C[C@@H]1CN2c1cnc2c(ccc(F)c2c1)C(=O)Nc1cnccc1[C@@H]1C[C@H](C)C[C@H](N)C1
Show InChI InChI=1S/C29H33FN6O3/c1-16-7-17(9-18(31)8-16)22-5-6-32-13-26(22)34-28(37)23-3-4-25(30)24-11-19(12-33-27(23)24)35-14-21-10-20(35)15-36(21)29(38)39-2/h3-6,11-13,16-18,20-21H,7-10,14-15,31H2,1-2H3,(H,34,37)/t16-,17+,18-,20+,21+/m0/s1
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US Patent


Assay Description
Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US10450296 (2019)


BindingDB Entry DOI: 10.7270/Q2MP55J7
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM376759
PNG
(N-{4-[(1R,3S,5S)-3-amino-5-methylcyclohexyl]pyridi...)
Show SMILES C[C@@H]1C[C@H](N)C[C@@H](C1)c1ccncc1NC(=O)c1ccc(F)c2cc(nnc12)-c1c(F)cccc1F
Show InChI InChI=1S/C27H24F3N5O/c1-14-9-15(11-16(31)10-14)17-7-8-32-13-24(17)33-27(36)18-5-6-20(28)19-12-23(34-35-26(18)19)25-21(29)3-2-4-22(25)30/h2-8,12-16H,9-11,31H2,1H3,(H,33,36)/t14-,15+,16-/m0/s1
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US Patent


Assay Description
Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US10450296 (2019)


BindingDB Entry DOI: 10.7270/Q2MP55J7
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM376765
PNG
(N-(4-((1R,3S,5S)-3-Amino-5-methylcyclohexyl)pyridi...)
Show SMILES C[C@@H]1C[C@H](N)C[C@@H](C1)c1ccncc1NC(=O)c1ccc(F)c2cc(cnc12)N1CC2CCC1C2
Show InChI InChI=1S/C28H32FN5O/c1-16-8-18(11-19(30)9-16)22-6-7-31-14-26(22)33-28(35)23-4-5-25(29)24-12-21(13-32-27(23)24)34-15-17-2-3-20(34)10-17/h4-7,12-14,16-20H,2-3,8-11,15,30H2,1H3,(H,33,35)/t16-,17?,18+,19-,20?/m0/s1
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US Patent


Assay Description
Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US10450296 (2019)


BindingDB Entry DOI: 10.7270/Q2MP55J7
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))
BDBM376765
PNG
(N-(4-((1R,3S,5S)-3-Amino-5-methylcyclohexyl)pyridi...)
Show SMILES C[C@@H]1C[C@H](N)C[C@@H](C1)c1ccncc1NC(=O)c1ccc(F)c2cc(cnc12)N1CC2CCC1C2
Show InChI InChI=1S/C28H32FN5O/c1-16-8-18(11-19(30)9-16)22-6-7-31-14-26(22)33-28(35)23-4-5-25(29)24-12-21(13-32-27(23)24)34-15-17-2-3-20(34)10-17/h4-7,12-14,16-20H,2-3,8-11,15,30H2,1H3,(H,33,35)/t16-,17?,18+,19-,20?/m0/s1
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US Patent


Assay Description
Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US10450296 (2019)


BindingDB Entry DOI: 10.7270/Q2MP55J7
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM376770
PNG
(N-(4-((1R,3S,5S)-3-Amino-5-methylcyclohexyl)pyridi...)
Show SMILES COC1CCCN(CC1)c1cnc2c(ccc(F)c2c1)C(=O)Nc1cnccc1[C@@H]1C[C@H](C)C[C@H](N)C1
Show InChI InChI=1S/C29H36FN5O2/c1-18-12-19(14-20(31)13-18)23-7-9-32-17-27(23)34-29(36)24-5-6-26(30)25-15-21(16-33-28(24)25)35-10-3-4-22(37-2)8-11-35/h5-7,9,15-20,22H,3-4,8,10-14,31H2,1-2H3,(H,34,36)/t18-,19+,20-,22?/m0/s1
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US Patent


Assay Description
Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US10450296 (2019)


BindingDB Entry DOI: 10.7270/Q2MP55J7
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))
BDBM376772
PNG
(N-(4-((1R,3S,5S)-3-Amino-5-methylcyclohexyl)pyridi...)
Show SMILES C[C@@H]1C[C@H](N)C[C@@H](C1)c1ccncc1NC(=O)c1ccc(F)c2cc(cnc12)N1CC2(CC(O)C2)C1
Show InChI InChI=1S/C28H32FN5O2/c1-16-6-17(8-18(30)7-16)21-4-5-31-13-25(21)33-27(36)22-2-3-24(29)23-9-19(12-32-26(22)23)34-14-28(15-34)10-20(35)11-28/h2-5,9,12-13,16-18,20,35H,6-8,10-11,14-15,30H2,1H3,(H,33,36)/t16-,17+,18-/m0/s1
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US Patent


Assay Description
Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US10450296 (2019)


BindingDB Entry DOI: 10.7270/Q2MP55J7
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM376696
PNG
(N-{4-[(1R,3S,5S)-3-Amino-5-methylcyclohexyl]pyridi...)
Show SMILES C[C@@H]1C[C@H](N)C[C@@H](C1)c1ccncc1NC(=O)c1ccc(F)c2cc(cnc12)N1CC[C@H](O)[C@@H](F)C1
Show InChI InChI=1S/C27H31F2N5O2/c1-15-8-16(10-17(30)9-15)19-4-6-31-13-24(19)33-27(36)20-2-3-22(28)21-11-18(12-32-26(20)21)34-7-5-25(35)23(29)14-34/h2-4,6,11-13,15-17,23,25,35H,5,7-10,14,30H2,1H3,(H,33,36)/t15-,16+,17-,23-,25-/m0/s1
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US Patent


Assay Description
Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US10450296 (2019)


BindingDB Entry DOI: 10.7270/Q2MP55J7
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))
BDBM376696
PNG
(N-{4-[(1R,3S,5S)-3-Amino-5-methylcyclohexyl]pyridi...)
Show SMILES C[C@@H]1C[C@H](N)C[C@@H](C1)c1ccncc1NC(=O)c1ccc(F)c2cc(cnc12)N1CC[C@H](O)[C@@H](F)C1
Show InChI InChI=1S/C27H31F2N5O2/c1-15-8-16(10-17(30)9-15)19-4-6-31-13-24(19)33-27(36)20-2-3-22(28)21-11-18(12-32-26(20)21)34-7-5-25(35)23(29)14-34/h2-4,6,11-13,15-17,23,25,35H,5,7-10,14,30H2,1H3,(H,33,36)/t15-,16+,17-,23-,25-/m0/s1
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US Patent


Assay Description
Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US10450296 (2019)


BindingDB Entry DOI: 10.7270/Q2MP55J7
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))
BDBM376673
PNG
(N-{4-[(1R,3S,5S)-3-Amino-5-methylcyclohexyl]pyridi...)
Show SMILES C[C@@H]1C[C@H](N)C[C@@H](C1)c1ccncc1NC(=O)c1ccc(F)c2cc(cnc12)N1CC[C@@H](C1)C#N
Show InChI InChI=1S/C27H29FN6O/c1-16-8-18(10-19(30)9-16)21-4-6-31-14-25(21)33-27(35)22-2-3-24(28)23-11-20(13-32-26(22)23)34-7-5-17(12-29)15-34/h2-4,6,11,13-14,16-19H,5,7-10,15,30H2,1H3,(H,33,35)/t16-,17+,18+,19-/m0/s1
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Incyte Corporation

US Patent


Assay Description
Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US10450296 (2019)


BindingDB Entry DOI: 10.7270/Q2MP55J7
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM376675
PNG
(N-{4-[(1R,3S,5S)-3-Amino-5-methylcyclohexyl]pyridi...)
Show SMILES C[C@@H]1C[C@H](N)C[C@@H](C1)c1ccncc1NC(=O)c1ccc(F)c2cc(cnc12)N1CC(F)C1
Show InChI InChI=1S/C25H27F2N5O/c1-14-6-15(8-17(28)7-14)19-4-5-29-11-23(19)31-25(33)20-2-3-22(27)21-9-18(10-30-24(20)21)32-12-16(26)13-32/h2-5,9-11,14-17H,6-8,12-13,28H2,1H3,(H,31,33)/t14-,15+,17-/m0/s1
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US Patent


Assay Description
Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US10450296 (2019)


BindingDB Entry DOI: 10.7270/Q2MP55J7
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM376677
PNG
(N-{4-[(1R,3S,5S)-3-Amino-5-methylcyclohexyl]pyridi...)
Show SMILES CO[C@H]1CCCN(C1)c1cnc2c(ccc(F)c2c1)C(=O)Nc1cnccc1[C@@H]1C[C@H](C)C[C@H](N)C1
Show InChI InChI=1S/C28H34FN5O2/c1-17-10-18(12-19(30)11-17)22-7-8-31-15-26(22)33-28(35)23-5-6-25(29)24-13-20(14-32-27(23)24)34-9-3-4-21(16-34)36-2/h5-8,13-15,17-19,21H,3-4,9-12,16,30H2,1-2H3,(H,33,35)/t17-,18+,19-,21-/m0/s1
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US Patent


Assay Description
Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US10450296 (2019)


BindingDB Entry DOI: 10.7270/Q2MP55J7
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))
BDBM376678
PNG
(N-{4-[(1R,3S,5S)-3-Amino-5-methylcyclohexyl]pyridi...)
Show SMILES CO[C@@H]1CCCN(C1)c1cnc2c(ccc(F)c2c1)C(=O)Nc1cnccc1[C@@H]1C[C@H](C)C[C@H](N)C1
Show InChI InChI=1S/C28H34FN5O2/c1-17-10-18(12-19(30)11-17)22-7-8-31-15-26(22)33-28(35)23-5-6-25(29)24-13-20(14-32-27(23)24)34-9-3-4-21(16-34)36-2/h5-8,13-15,17-19,21H,3-4,9-12,16,30H2,1-2H3,(H,33,35)/t17-,18+,19-,21+/m0/s1
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US Patent


Assay Description
Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US10450296 (2019)


BindingDB Entry DOI: 10.7270/Q2MP55J7
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM376679
PNG
(N-{4-[(1R,3S,5S)-3-Amino-5-methylcyclohexyl]pyridi...)
Show SMILES C[C@@H]1C[C@H](N)C[C@@H](C1)c1ccncc1NC(=O)c1ccc(F)c2cc(cnc12)C1CC1
Show InChI InChI=1S/C25H27FN4O/c1-14-8-16(10-18(27)9-14)19-6-7-28-13-23(19)30-25(31)20-4-5-22(26)21-11-17(15-2-3-15)12-29-24(20)21/h4-7,11-16,18H,2-3,8-10,27H2,1H3,(H,30,31)/t14-,16+,18-/m0/s1
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US Patent


Assay Description
Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US10450296 (2019)


BindingDB Entry DOI: 10.7270/Q2MP55J7
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM376683
PNG
(Tert-Butyl {(1S,3R,5S)-3-[3-({[3-(2,6-difluorophen...)
Show SMILES C[C@@H]1C[C@H](N)C[C@@H](C1)c1ccncc1NC(=O)c1ccc(F)c2cc(cnc12)-c1c(F)cccc1F
Show InChI InChI=1S/C28H25F3N4O/c1-15-9-16(11-18(32)10-15)19-7-8-33-14-25(19)35-28(36)20-5-6-22(29)21-12-17(13-34-27(20)21)26-23(30)3-2-4-24(26)31/h2-8,12-16,18H,9-11,32H2,1H3,(H,35,36)/t15-,16+,18-/m0/s1
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US Patent


Assay Description
Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US10450296 (2019)


BindingDB Entry DOI: 10.7270/Q2MP55J7
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))
BDBM376687
PNG
(N-(4-((1R,3S,5S)-3-Amino-5-methylcyclohexyl)pyridi...)
Show SMILES CCN(C)c1cnc2c(ccc(F)c2c1)C(=O)Nc1cnccc1[C@@H]1C[C@H](C)C[C@H](N)C1
Show InChI InChI=1S/C25H30FN5O/c1-4-31(3)18-12-21-22(26)6-5-20(24(21)29-13-18)25(32)30-23-14-28-8-7-19(23)16-9-15(2)10-17(27)11-16/h5-8,12-17H,4,9-11,27H2,1-3H3,(H,30,32)/t15-,16+,17-/m0/s1
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US Patent


Assay Description
Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US10450296 (2019)


BindingDB Entry DOI: 10.7270/Q2MP55J7
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))
BDBM376691
PNG
(N-{4-[(1R,3S,5S)-3-Amino-5-methylcyclohexyl]pyridi...)
Show SMILES C[C@@H]1C[C@H](N)C[C@@H](C1)c1ccncc1NC(=O)c1ccc(F)c2cc(cnc12)N(C)C1CCC1
Show InChI InChI=1S/C27H32FN5O/c1-16-10-17(12-18(29)11-16)21-8-9-30-15-25(21)32-27(34)22-6-7-24(28)23-13-20(14-31-26(22)23)33(2)19-4-3-5-19/h6-9,13-19H,3-5,10-12,29H2,1-2H3,(H,32,34)/t16-,17+,18-/m0/s1
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US Patent


Assay Description
Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US10450296 (2019)


BindingDB Entry DOI: 10.7270/Q2MP55J7
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM376695
PNG
(N-{4-[(1R,3S,5S)-3-Amino-5-methylcyclohexyl]pyridi...)
Show SMILES C[C@@H]1C[C@H](N)C[C@@H](C1)c1ccncc1NC(=O)c1ccc(F)c2cc(cnc12)N1CCCC(F)(F)C1
Show InChI InChI=1S/C27H30F3N5O/c1-16-9-17(11-18(31)10-16)20-5-7-32-14-24(20)34-26(36)21-3-4-23(28)22-12-19(13-33-25(21)22)35-8-2-6-27(29,30)15-35/h3-5,7,12-14,16-18H,2,6,8-11,15,31H2,1H3,(H,34,36)/t16-,17+,18-/m0/s1
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US Patent


Assay Description
Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US10450296 (2019)


BindingDB Entry DOI: 10.7270/Q2MP55J7
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM376696
PNG
(N-{4-[(1R,3S,5S)-3-Amino-5-methylcyclohexyl]pyridi...)
Show SMILES C[C@@H]1C[C@H](N)C[C@@H](C1)c1ccncc1NC(=O)c1ccc(F)c2cc(cnc12)N1CC[C@H](O)[C@@H](F)C1
Show InChI InChI=1S/C27H31F2N5O2/c1-15-8-16(10-17(30)9-15)19-4-6-31-13-24(19)33-27(36)20-2-3-22(28)21-11-18(12-32-26(20)21)34-7-5-25(35)23(29)14-34/h2-4,6,11-13,15-17,23,25,35H,5,7-10,14,30H2,1H3,(H,33,36)/t15-,16+,17-,23-,25-/m0/s1
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US Patent


Assay Description
Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US10450296 (2019)


BindingDB Entry DOI: 10.7270/Q2MP55J7
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM376697
PNG
(N-{4-[(1R,3S,5S)-3-Amino-5-methylcyclohexyl]pyridi...)
Show SMILES C[C@@H]1C[C@H](N)C[C@@H](C1)c1ccncc1NC(=O)c1ccc(F)c2cc(cnc12)N1CCN(C)CC1
Show InChI InChI=1S/C27H33FN6O/c1-17-11-18(13-19(29)12-17)21-5-6-30-16-25(21)32-27(35)22-3-4-24(28)23-14-20(15-31-26(22)23)34-9-7-33(2)8-10-34/h3-6,14-19H,7-13,29H2,1-2H3,(H,32,35)/t17-,18+,19-/m0/s1
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US Patent


Assay Description
Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US10450296 (2019)


BindingDB Entry DOI: 10.7270/Q2MP55J7
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM376705
PNG
(N-(4-((1R,3S,5S)-3-Amino-5-methylcyclohexyl)pyridi...)
Show SMILES C[C@@H]1C[C@H](N)C[C@@H](C1)c1ccncc1NC(=O)c1ccc(F)c2cc(cnc12)N1CCO[C@@H](C)C1
Show InChI InChI=1S/C27H32FN5O2/c1-16-9-18(11-19(29)10-16)21-5-6-30-14-25(21)32-27(34)22-3-4-24(28)23-12-20(13-31-26(22)23)33-7-8-35-17(2)15-33/h3-6,12-14,16-19H,7-11,15,29H2,1-2H3,(H,32,34)/t16-,17-,18+,19-/m0/s1
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US Patent


Assay Description
Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US10450296 (2019)


BindingDB Entry DOI: 10.7270/Q2MP55J7
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM376722
PNG
(N-(4-((1R,3S,5S)-3-amino-5-methylcyclohexyl)pyridi...)
Show SMILES CC(C)[C@@H](C)Nc1cnc2c(ccc(F)c2c1)C(=O)Nc1cnccc1[C@@H]1C[C@H](C)C[C@H](N)C1
Show InChI InChI=1S/C27H34FN5O/c1-15(2)17(4)32-20-12-23-24(28)6-5-22(26(23)31-13-20)27(34)33-25-14-30-8-7-21(25)18-9-16(3)10-19(29)11-18/h5-8,12-19,32H,9-11,29H2,1-4H3,(H,33,34)/t16-,17+,18+,19-/m0/s1
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US Patent


Assay Description
Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US10450296 (2019)


BindingDB Entry DOI: 10.7270/Q2MP55J7
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))
BDBM376723
PNG
(N-(4-((1R,3S,5S)-3-Amino-5-methylcyclohexyl)pyridi...)
Show SMILES CCCN(C)c1cnc2c(ccc(F)c2c1)C(=O)Nc1cnccc1[C@@H]1C[C@H](C)C[C@H](N)C1
Show InChI InChI=1S/C26H32FN5O/c1-4-9-32(3)19-13-22-23(27)6-5-21(25(22)30-14-19)26(33)31-24-15-29-8-7-20(24)17-10-16(2)11-18(28)12-17/h5-8,13-18H,4,9-12,28H2,1-3H3,(H,31,33)/t16-,17+,18-/m0/s1
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US Patent


Assay Description
Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US10450296 (2019)


BindingDB Entry DOI: 10.7270/Q2MP55J7
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM376724
PNG
(N-(4-((1R,3S,5S)-3-Amino-5-methylcyclohexyl)pyridi...)
Show SMILES CC(C)N(C)c1cnc2c(ccc(F)c2c1)C(=O)Nc1cnccc1[C@@H]1C[C@H](C)C[C@H](N)C1
Show InChI InChI=1S/C26H32FN5O/c1-15(2)32(4)19-12-22-23(27)6-5-21(25(22)30-13-19)26(33)31-24-14-29-8-7-20(24)17-9-16(3)10-18(28)11-17/h5-8,12-18H,9-11,28H2,1-4H3,(H,31,33)/t16-,17+,18-/m0/s1
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US Patent


Assay Description
Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US10450296 (2019)


BindingDB Entry DOI: 10.7270/Q2MP55J7
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM376727
PNG
(N-(4-((1R,3S,5S)-3-Amino-5-methylcyclohexyl)pyridi...)
Show SMILES C[C@@H]1C[C@H](N)C[C@@H](C1)c1ccncc1NC(=O)c1ccc(F)c2cc(cnc12)-c1cc(F)cc2cccnc12
Show InChI InChI=1S/C31H27F2N5O/c1-17-9-19(12-22(34)10-17)23-6-8-35-16-28(23)38-31(39)24-4-5-27(33)26-13-20(15-37-30(24)26)25-14-21(32)11-18-3-2-7-36-29(18)25/h2-8,11,13-17,19,22H,9-10,12,34H2,1H3,(H,38,39)/t17-,19+,22-/m0/s1
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US Patent


Assay Description
Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US10450296 (2019)


BindingDB Entry DOI: 10.7270/Q2MP55J7
More data for this
Ligand-Target Pair
Displayed 1 to 50 (of 510 total )  |  Next  |  Last  >>
* indicates data uncertainty>20%