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Patent code US10450297

Compile Data Set for Download or QSAR

Found 341 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Focal adhesion kinase 1 (FAK) (aa 410-689)


(Homo sapiens (Human))
BDBM418652
PNG
(4-{[4-({3- [methyl(methylsulfonyl)amino]benzyl} am...)
Show SMILES CN(c1cccc(CNc2nc(Nc3ccc(cc3)C(N)=O)ncc2C(F)(F)F)c1)S(C)(=O)=O
Show InChI InChI=1S/C21H21F3N6O3S/c1-30(34(2,32)33)16-5-3-4-13(10-16)11-26-19-17(21(22,23)24)12-27-20(29-19)28-15-8-6-14(7-9-15)18(25)31/h3-10,12H,11H2,1-2H3,(H2,25,31)(H2,26,27,28,29)
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n/an/a 0.380n/an/an/an/an/an/a



Pfizer, Inc.

US Patent


Assay Description
The in vitro activity of the compounds of the compounds of the invention may be determined by the following procedure. More particularly, the followi...


US Patent US10450297 (2019)


BindingDB Entry DOI: 10.7270/Q2T72KQP
More data for this
Ligand-Target Pair
Focal adhesion kinase 1 (FAK) (aa 410-689)


(Homo sapiens (Human))
BDBM418597
PNG
(US10450297, Example 40 | methyl 4-({4-[({2- [methy...)
Show SMILES COC(=O)c1ccc(Nc2ncc(c(NCc3cccnc3N(C)S(C)(=O)=O)n2)C(F)(F)F)cc1
Show InChI InChI=1S/C21H21F3N6O4S/c1-30(35(3,32)33)18-14(5-4-10-25-18)11-26-17-16(21(22,23)24)12-27-20(29-17)28-15-8-6-13(7-9-15)19(31)34-2/h4-10,12H,11H2,1-3H3,(H2,26,27,28,29)
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n/an/a 0.590n/an/an/an/an/an/a



Pfizer, Inc.

US Patent


Assay Description
The in vitro activity of the compounds of the compounds of the invention may be determined by the following procedure. More particularly, the followi...


US Patent US10450297 (2019)


BindingDB Entry DOI: 10.7270/Q2T72KQP
More data for this
Ligand-Target Pair
Focal adhesion kinase 1 (FAK) (aa 410-689)


(Homo sapiens (Human))
BDBM418649
PNG
(N-methyl-4-{[4-({2- [methyl(methylsulfonyl)amino]b...)
Show SMILES CNC(=O)c1ccc(Nc2ncc(c(NCc3ccccc3N(C)S(C)(=O)=O)n2)C(F)(F)F)cc1
Show InChI InChI=1S/C22H23F3N6O3S/c1-26-20(32)14-8-10-16(11-9-14)29-21-28-13-17(22(23,24)25)19(30-21)27-12-15-6-4-5-7-18(15)31(2)35(3,33)34/h4-11,13H,12H2,1-3H3,(H,26,32)(H2,27,28,29,30)
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Pfizer, Inc.

US Patent


Assay Description
The in vitro activity of the compounds of the compounds of the invention may be determined by the following procedure. More particularly, the followi...


US Patent US10450297 (2019)


BindingDB Entry DOI: 10.7270/Q2T72KQP
More data for this
Ligand-Target Pair
Focal adhesion kinase 1 (FAK) (aa 410-689)


(Homo sapiens (Human))
BDBM418606
PNG
(N-[3-({[2-anilino-5- (trifluoromethyl)pyrimidin-4-...)
Show SMILES CN(c1ncccc1CNc1nc(Nc2ccccc2)ncc1C(F)(F)F)S(C)(=O)=O
Show InChI InChI=1S/C19H19F3N6O2S/c1-28(31(2,29)30)17-13(7-6-10-23-17)11-24-16-15(19(20,21)22)12-25-18(27-16)26-14-8-4-3-5-9-14/h3-10,12H,11H2,1-2H3,(H2,24,25,26,27)
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Pfizer, Inc.

US Patent


Assay Description
The in vitro activity of the compounds of the compounds of the invention may be determined by the following procedure. More particularly, the followi...


US Patent US10450297 (2019)


BindingDB Entry DOI: 10.7270/Q2T72KQP
More data for this
Ligand-Target Pair
Focal adhesion kinase 1 (FAK) (aa 410-689)


(Homo sapiens (Human))
BDBM418604
PNG
(3-methoxy-4-({4-[({2- [methyl(methylsuffonyl)amino...)
Show SMILES COc1cc(ccc1Nc1ncc(c(NCc2cccnc2N(C)S(C)(=O)=O)n1)C(F)(F)F)C(N)=O
Show InChI InChI=1S/C21H22F3N7O4S/c1-31(36(3,33)34)19-13(5-4-8-26-19)10-27-18-14(21(22,23)24)11-28-20(30-18)29-15-7-6-12(17(25)32)9-16(15)35-2/h4-9,11H,10H2,1-3H3,(H2,25,32)(H2,27,28,29,30)
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Pfizer, Inc.

US Patent


Assay Description
The in vitro activity of the compounds of the compounds of the invention may be determined by the following procedure. More particularly, the followi...


US Patent US10450297 (2019)


BindingDB Entry DOI: 10.7270/Q2T72KQP
More data for this
Ligand-Target Pair
Focal adhesion kinase 1 (FAK) (aa 410-689)


(Homo sapiens (Human))
BDBM418603
PNG
(3-methoxy-4-{[4-{[3- (methylsulfonyl)benzyl]amino}...)
Show SMILES COc1cc(ccc1Nc1ncc(c(NCc2cccc(c2)S(C)(=O)=O)n1)C(F)(F)F)C(N)=O
Show InChI InChI=1S/C21H20F3N5O4S/c1-33-17-9-13(18(25)30)6-7-16(17)28-20-27-11-15(21(22,23)24)19(29-20)26-10-12-4-3-5-14(8-12)34(2,31)32/h3-9,11H,10H2,1-2H3,(H2,25,30)(H2,26,27,28,29)
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Pfizer, Inc.

US Patent


Assay Description
The in vitro activity of the compounds of the compounds of the invention may be determined by the following procedure. More particularly, the followi...


US Patent US10450297 (2019)


BindingDB Entry DOI: 10.7270/Q2T72KQP
More data for this
Ligand-Target Pair
Focal adhesion kinase 1 (FAK) (aa 410-689)


(Homo sapiens (Human))
BDBM418656
PNG
(N-[3-({[2-{[4-(aminomethyl)phenyl]amino}- 5-(trifl...)
Show SMILES CN(c1ncccc1CNc1nc(Nc2ccc(CN)cc2)ncc1C(F)(F)F)S(C)(=O)=O
Show InChI InChI=1S/C20H22F3N7O2S/c1-30(33(2,31)32)18-14(4-3-9-25-18)11-26-17-16(20(21,22)23)12-27-19(29-17)28-15-7-5-13(10-24)6-8-15/h3-9,12H,10-11,24H2,1-2H3,(H2,26,27,28,29)
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Pfizer, Inc.

US Patent


Assay Description
The in vitro activity of the compounds of the compounds of the invention may be determined by the following procedure. More particularly, the followi...


US Patent US10450297 (2019)


BindingDB Entry DOI: 10.7270/Q2T72KQP
More data for this
Ligand-Target Pair
Focal adhesion kinase 1 (FAK) (aa 410-689)


(Homo sapiens (Human))
BDBM418605
PNG
(3-methoxy-4-({4-[({6-methyl-2- [methyl(methylsulfo...)
Show SMILES COc1cc(ccc1Nc1ncc(c(NCc2ccc(C)nc2N(C)S(C)(=O)=O)n1)C(F)(F)F)C(N)=O
Show InChI InChI=1S/C22H24F3N7O4S/c1-12-5-6-14(20(29-12)32(2)37(4,34)35)10-27-19-15(22(23,24)25)11-28-21(31-19)30-16-8-7-13(18(26)33)9-17(16)36-3/h5-9,11H,10H2,1-4H3,(H2,26,33)(H2,27,28,30,31)
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Pfizer, Inc.

US Patent


Assay Description
The in vitro activity of the compounds of the compounds of the invention may be determined by the following procedure. More particularly, the followi...


US Patent US10450297 (2019)


BindingDB Entry DOI: 10.7270/Q2T72KQP
More data for this
Ligand-Target Pair
Focal adhesion kinase 1 (FAK) (aa 410-689)


(Homo sapiens (Human))
BDBM418655
PNG
(N-methyl-4-({4-[({6-methyl-4- [methyl(methylsulfon...)
Show SMILES CNC(=O)c1ccc(Nc2ncc(c(NCc3cnc(C)cc3N(C)S(C)(=O)=O)n2)C(F)(F)F)cc1
Show InChI InChI=1S/C22H24F3N7O3S/c1-13-9-18(32(3)36(4,34)35)15(10-27-13)11-28-19-17(22(23,24)25)12-29-21(31-19)30-16-7-5-14(6-8-16)20(33)26-2/h5-10,12H,11H2,1-4H3,(H,26,33)(H2,28,29,30,31)
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Pfizer, Inc.

US Patent


Assay Description
The in vitro activity of the compounds of the compounds of the invention may be determined by the following procedure. More particularly, the followi...


US Patent US10450297 (2019)


BindingDB Entry DOI: 10.7270/Q2T72KQP
More data for this
Ligand-Target Pair
Focal adhesion kinase 1 (FAK) (aa 410-689)


(Homo sapiens (Human))
BDBM418653
PNG
(N-methyl-4-{[4-({3- [methyl(methylsulfonyl)amino]b...)
Show SMILES CNC(=O)c1ccc(Nc2ncc(c(NCc3cccc(c3)N(C)S(C)(=O)=O)n2)C(F)(F)F)cc1
Show InChI InChI=1S/C22H23F3N6O3S/c1-26-20(32)15-7-9-16(10-8-15)29-21-28-13-18(22(23,24)25)19(30-21)27-12-14-5-4-6-17(11-14)31(2)35(3,33)34/h4-11,13H,12H2,1-3H3,(H,26,32)(H2,27,28,29,30)
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Pfizer, Inc.

US Patent


Assay Description
The in vitro activity of the compounds of the compounds of the invention may be determined by the following procedure. More particularly, the followi...


US Patent US10450297 (2019)


BindingDB Entry DOI: 10.7270/Q2T72KQP
More data for this
Ligand-Target Pair
Focal adhesion kinase 1 (FAK) (aa 410-689)


(Homo sapiens (Human))
BDBM418659
PNG
(4-{[4-({2-methyl-6- [methyl(methylsulfonyl)amino]b...)
Show SMILES CN(c1cccc(C)c1CNc1nc(Nc2ccc(cc2)C(N)=O)ncc1C(F)(F)F)S(C)(=O)=O
Show InChI InChI=1S/C22H23F3N6O3S/c1-13-5-4-6-18(31(2)35(3,33)34)16(13)11-27-20-17(22(23,24)25)12-28-21(30-20)29-15-9-7-14(8-10-15)19(26)32/h4-10,12H,11H2,1-3H3,(H2,26,32)(H2,27,28,29,30)
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Pfizer, Inc.

US Patent


Assay Description
The in vitro activity of the compounds of the compounds of the invention may be determined by the following procedure. More particularly, the followi...


US Patent US10450297 (2019)


BindingDB Entry DOI: 10.7270/Q2T72KQP
More data for this
Ligand-Target Pair
Focal adhesion kinase 1 (FAK) (aa 410-689)


(Homo sapiens (Human))
BDBM418607
PNG
(N-[3-({[2-anilino-5- (trifluoromethyl)pyrimidin-4-...)
Show SMILES CN(c1nc(C)ccc1CNc1nc(Nc2ccccc2)ncc1C(F)(F)F)S(C)(=O)=O
Show InChI InChI=1S/C20H21F3N6O2S/c1-13-9-10-14(18(26-13)29(2)32(3,30)31)11-24-17-16(20(21,22)23)12-25-19(28-17)27-15-7-5-4-6-8-15/h4-10,12H,11H2,1-3H3,(H2,24,25,27,28)
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Pfizer, Inc.

US Patent


Assay Description
The in vitro activity of the compounds of the compounds of the invention may be determined by the following procedure. More particularly, the followi...


US Patent US10450297 (2019)


BindingDB Entry DOI: 10.7270/Q2T72KQP
More data for this
Ligand-Target Pair
Focal adhesion kinase 1 (FAK) (aa 410-689)


(Homo sapiens (Human))
BDBM418610
PNG
(N-methyl-4-({4-[({6-methyl-2- [methyl(methylsulfon...)
Show SMILES CNC(=O)c1ccc(Nc2ncc(c(NCc3ccc(C)nc3N(C)S(C)(=O)=O)n2)C(F)(F)F)cc1
Show InChI InChI=1S/C22H24F3N7O3S/c1-13-5-6-15(19(29-13)32(3)36(4,34)35)11-27-18-17(22(23,24)25)12-28-21(31-18)30-16-9-7-14(8-10-16)20(33)26-2/h5-10,12H,11H2,1-4H3,(H,26,33)(H2,27,28,30,31)
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Pfizer, Inc.

US Patent


Assay Description
The in vitro activity of the compounds of the compounds of the invention may be determined by the following procedure. More particularly, the followi...


US Patent US10450297 (2019)


BindingDB Entry DOI: 10.7270/Q2T72KQP
More data for this
Ligand-Target Pair
Focal adhesion kinase 1 (FAK) (aa 410-689)


(Homo sapiens (Human))
BDBM418624
PNG
(N-[2-(([2-anilino-5- (trifluoromethyl)pyrimidin-4-...)
Show SMILES CS(=O)(=O)Nc1ccccc1CNc1nc(Nc2ccccc2)ncc1C(F)(F)F
Show InChI InChI=1S/C19H18F3N5O2S/c1-30(28,29)27-16-10-6-5-7-13(16)11-23-17-15(19(20,21)22)12-24-18(26-17)25-14-8-3-2-4-9-14/h2-10,12,27H,11H2,1H3,(H2,23,24,25,26)
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Pfizer, Inc.

US Patent


Assay Description
The in vitro activity of the compounds of the compounds of the invention may be determined by the following procedure. More particularly, the followi...


US Patent US10450297 (2019)


BindingDB Entry DOI: 10.7270/Q2T72KQP
More data for this
Ligand-Target Pair
Focal adhesion kinase 1 (FAK) (aa 410-689)


(Homo sapiens (Human))
BDBM418634
PNG
(N-[5-({[2-anilino-5- (trifluoromethyl)pyrimidin-4-...)
Show SMILES CN(c1cc(C)ncc1CNc1nc(Nc2ccccc2)ncc1C(F)(F)F)S(C)(=O)=O
Show InChI InChI=1S/C20H21F3N6O2S/c1-13-9-17(29(2)32(3,30)31)14(10-24-13)11-25-18-16(20(21,22)23)12-26-19(28-18)27-15-7-5-4-6-8-15/h4-10,12H,11H2,1-3H3,(H2,25,26,27,28)
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Pfizer, Inc.

US Patent


Assay Description
The in vitro activity of the compounds of the compounds of the invention may be determined by the following procedure. More particularly, the followi...


US Patent US10450297 (2019)


BindingDB Entry DOI: 10.7270/Q2T72KQP
More data for this
Ligand-Target Pair
Focal adhesion kinase 1 (FAK) (aa 410-689)


(Homo sapiens (Human))
BDBM418651
PNG
(US10450297, Example 98 | ethyl [4-({4-[({2- [methy...)
Show SMILES CCOC(=O)Cc1ccc(Nc2ncc(c(NCc3cccnc3N(C)S(C)(=O)=O)n2)C(F)(F)F)cc1
Show InChI InChI=1S/C23H25F3N6O4S/c1-4-36-19(33)12-15-7-9-17(10-8-15)30-22-29-14-18(23(24,25)26)20(31-22)28-13-16-6-5-11-27-21(16)32(2)37(3,34)35/h5-11,14H,4,12-13H2,1-3H3,(H2,28,29,30,31)
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Pfizer, Inc.

US Patent


Assay Description
The in vitro activity of the compounds of the compounds of the invention may be determined by the following procedure. More particularly, the followi...


US Patent US10450297 (2019)


BindingDB Entry DOI: 10.7270/Q2T72KQP
More data for this
Ligand-Target Pair
Focal adhesion kinase 1 (FAK) (aa 410-689)


(Homo sapiens (Human))
BDBM418609
PNG
(N-methyl-4-({4-[({2- [methyl(methylsulfonyl)amino]...)
Show SMILES CNC(=O)c1ccc(Nc2ncc(c(NCc3cccnc3N(C)S(C)(=O)=O)n2)C(F)(F)F)cc1
Show InChI InChI=1S/C21H22F3N7O3S/c1-25-19(32)13-6-8-15(9-7-13)29-20-28-12-16(21(22,23)24)17(30-20)27-11-14-5-4-10-26-18(14)31(2)35(3,33)34/h4-10,12H,11H2,1-3H3,(H,25,32)(H2,27,28,29,30)
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Pfizer, Inc.

US Patent


Assay Description
The in vitro activity of the compounds of the compounds of the invention may be determined by the following procedure. More particularly, the followi...


US Patent US10450297 (2019)


BindingDB Entry DOI: 10.7270/Q2T72KQP
More data for this
Ligand-Target Pair
Focal adhesion kinase 1 (FAK) (aa 410-689)


(Homo sapiens (Human))
BDBM418650
PNG
(N-ethyl-4-({4-[({3- [methyl(methylsulfonyl)amino]p...)
Show SMILES CCNC(=O)c1ccc(Nc2ncc(c(NCc3ncccc3N(C)S(C)(=O)=O)n2)C(F)(F)F)cc1
Show InChI InChI=1S/C22H24F3N7O3S/c1-4-26-20(33)14-7-9-15(10-8-14)30-21-29-12-16(22(23,24)25)19(31-21)28-13-17-18(6-5-11-27-17)32(2)36(3,34)35/h5-12H,4,13H2,1-3H3,(H,26,33)(H2,28,29,30,31)
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Pfizer, Inc.

US Patent


Assay Description
The in vitro activity of the compounds of the compounds of the invention may be determined by the following procedure. More particularly, the followi...


US Patent US10450297 (2019)


BindingDB Entry DOI: 10.7270/Q2T72KQP
More data for this
Ligand-Target Pair
Focal adhesion kinase 1 (FAK) (aa 410-689)


(Homo sapiens (Human))
BDBM418856
PNG
(N-[2-({[2-({4-[(1S)-1- aminoethyl]phenyl}amino)-5-...)
Show SMILES C[C@H](N)c1ccc(Nc2ncc(c(NCc3ncccc3N(C)S(C)(=O)=O)n2)C(F)(F)F)cc1
Show InChI InChI=1S/C21H24F3N7O2S/c1-13(25)14-6-8-15(9-7-14)29-20-28-11-16(21(22,23)24)19(30-20)27-12-17-18(5-4-10-26-17)31(2)34(3,32)33/h4-11,13H,12,25H2,1-3H3,(H2,27,28,29,30)/t13-/m0/s1
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Pfizer, Inc.

US Patent


Assay Description
The in vitro activity of the compounds of the compounds of the invention may be determined by the following procedure. More particularly, the followi...


US Patent US10450297 (2019)


BindingDB Entry DOI: 10.7270/Q2T72KQP
More data for this
Ligand-Target Pair
Focal adhesion kinase 1 (FAK) (aa 410-689)


(Homo sapiens (Human))
BDBM418889
PNG
(N-[3-({[2-{[4-({[2-hydroxy-1- (hydroxymethyl)ethyl...)
Show SMILES CN(c1ncccc1CNc1nc(Nc2ccc(CNC(CO)CO)cc2)ncc1C(F)(F)F)S(C)(=O)=O
Show InChI InChI=1S/C23H28F3N7O4S/c1-33(38(2,36)37)21-16(4-3-9-27-21)11-29-20-19(23(24,25)26)12-30-22(32-20)31-17-7-5-15(6-8-17)10-28-18(13-34)14-35/h3-9,12,18,28,34-35H,10-11,13-14H2,1-2H3,(H2,29,30,31,32)
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Pfizer, Inc.

US Patent


Assay Description
The in vitro activity of the compounds of the compounds of the invention may be determined by the following procedure. More particularly, the followi...


US Patent US10450297 (2019)


BindingDB Entry DOI: 10.7270/Q2T72KQP
More data for this
Ligand-Target Pair
Focal adhesion kinase 1 (FAK) (aa 410-689)


(Homo sapiens (Human))
BDBM418854
PNG
(N-[3-({[2-({4-[(1R)-1- aminoethyl]phenyl}amino)-5-...)
Show SMILES C[C@@H](N)c1ccc(Nc2ncc(c(NCc3cccnc3N(C)S(C)(=O)=O)n2)C(F)(F)F)cc1
Show InChI InChI=1S/C21H24F3N7O2S/c1-13(25)14-6-8-16(9-7-14)29-20-28-12-17(21(22,23)24)18(30-20)27-11-15-5-4-10-26-19(15)31(2)34(3,32)33/h4-10,12-13H,11,25H2,1-3H3,(H2,27,28,29,30)/t13-/m1/s1
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Pfizer, Inc.

US Patent


Assay Description
The in vitro activity of the compounds of the compounds of the invention may be determined by the following procedure. More particularly, the followi...


US Patent US10450297 (2019)


BindingDB Entry DOI: 10.7270/Q2T72KQP
More data for this
Ligand-Target Pair
Focal adhesion kinase 1 (FAK) (aa 410-689)


(Homo sapiens (Human))
BDBM418912
PNG
(N-[3-({[2-{[4-(1,2- dihydroxyethyl)phenyl]amino}-5...)
Show SMILES CN(c1ncccc1CNc1nc(Nc2ccc(cc2)C(O)CO)ncc1C(F)(F)F)S(C)(=O)=O
Show InChI InChI=1S/C21H23F3N6O4S/c1-30(35(2,33)34)19-14(4-3-9-25-19)10-26-18-16(21(22,23)24)11-27-20(29-18)28-15-7-5-13(6-8-15)17(32)12-31/h3-9,11,17,31-32H,10,12H2,1-2H3,(H2,26,27,28,29)
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Pfizer, Inc.

US Patent


Assay Description
The in vitro activity of the compounds of the compounds of the invention may be determined by the following procedure. More particularly, the followi...


US Patent US10450297 (2019)


BindingDB Entry DOI: 10.7270/Q2T72KQP
More data for this
Ligand-Target Pair
Focal adhesion kinase 1 (FAK) (aa 410-689)


(Homo sapiens (Human))
BDBM418814
PNG
(N-methyl-N-[3-({[2-{[4-(1H-tetrazol-5- yl)phenyl]a...)
Show SMILES CN(c1ncccc1CNc1nc(Nc2ccc(cc2)-c2nnn[nH]2)ncc1C(F)(F)F)S(C)(=O)=O
Show InChI InChI=1S/C20H19F3N10O2S/c1-33(36(2,34)35)18-13(4-3-9-24-18)10-25-17-15(20(21,22)23)11-26-19(28-17)27-14-7-5-12(6-8-14)16-29-31-32-30-16/h3-9,11H,10H2,1-2H3,(H2,25,26,27,28)(H,29,30,31,32)
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Pfizer, Inc.

US Patent


Assay Description
The in vitro activity of the compounds of the compounds of the invention may be determined by the following procedure. More particularly, the followi...


US Patent US10450297 (2019)


BindingDB Entry DOI: 10.7270/Q2T72KQP
More data for this
Ligand-Target Pair
Focal adhesion kinase 1 (FAK) (aa 410-689)


(Homo sapiens (Human))
BDBM418817
PNG
(N-methyl-4-({4-[({3- [methyl(methylsulfonyl)amino]...)
Show SMILES CNC(=O)c1ccc(Nc2ncc(c(NCc3nccnc3N(C)S(C)(=O)=O)n2)C(F)(F)F)cc1
Show InChI InChI=1S/C20H21F3N8O3S/c1-24-18(32)12-4-6-13(7-5-12)29-19-28-10-14(20(21,22)23)16(30-19)27-11-15-17(26-9-8-25-15)31(2)35(3,33)34/h4-10H,11H2,1-3H3,(H,24,32)(H2,27,28,29,30)
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Pfizer, Inc.

US Patent


Assay Description
The in vitro activity of the compounds of the compounds of the invention may be determined by the following procedure. More particularly, the followi...


US Patent US10450297 (2019)


BindingDB Entry DOI: 10.7270/Q2T72KQP
More data for this
Ligand-Target Pair
Focal adhesion kinase 1 (FAK) (aa 410-689)


(Homo sapiens (Human))
BDBM418819
PNG
(N-[3-({[2-{[4- (hydroxymethyl)phenyl]amino}-5- (tr...)
Show SMILES CN(c1ncccc1CNc1nc(Nc2ccc(CO)cc2)ncc1C(F)(F)F)S(C)(=O)=O
Show InChI InChI=1S/C20H21F3N6O3S/c1-29(33(2,31)32)18-14(4-3-9-24-18)10-25-17-16(20(21,22)23)11-26-19(28-17)27-15-7-5-13(12-30)6-8-15/h3-9,11,30H,10,12H2,1-2H3,(H2,25,26,27,28)
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Pfizer, Inc.

US Patent


Assay Description
The in vitro activity of the compounds of the compounds of the invention may be determined by the following procedure. More particularly, the followi...


US Patent US10450297 (2019)


BindingDB Entry DOI: 10.7270/Q2T72KQP
More data for this
Ligand-Target Pair
Focal adhesion kinase 1 (FAK) (aa 410-689)


(Homo sapiens (Human))
BDBM418820
PNG
(2-fluoro-4-({4-[({2- [methyl(methylsulfonyl)amino]...)
Show SMILES CN(c1ncccc1CNc1nc(Nc2ccc(C(N)=O)c(F)c2)ncc1C(F)(F)F)S(C)(=O)=O
Show InChI InChI=1S/C20H19F4N7O3S/c1-31(35(2,33)34)18-11(4-3-7-26-18)9-27-17-14(20(22,23)24)10-28-19(30-17)29-12-5-6-13(16(25)32)15(21)8-12/h3-8,10H,9H2,1-2H3,(H2,25,32)(H2,27,28,29,30)
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Pfizer, Inc.

US Patent


Assay Description
The in vitro activity of the compounds of the compounds of the invention may be determined by the following procedure. More particularly, the followi...


US Patent US10450297 (2019)


BindingDB Entry DOI: 10.7270/Q2T72KQP
More data for this
Ligand-Target Pair
Focal adhesion kinase 1 (FAK) (aa 410-689)


(Homo sapiens (Human))
BDBM418836
PNG
(2-methyl-4-({4-[({3- [methyl(methylsulfonyl)amino]...)
Show SMILES CN(c1cccnc1CNc1nc(Nc2ccc(C(N)=O)c(C)c2)ncc1C(F)(F)F)S(C)(=O)=O
Show InChI InChI=1S/C21H22F3N7O3S/c1-12-9-13(6-7-14(12)18(25)32)29-20-28-10-15(21(22,23)24)19(30-20)27-11-16-17(5-4-8-26-16)31(2)35(3,33)34/h4-10H,11H2,1-3H3,(H2,25,32)(H2,27,28,29,30)
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Pfizer, Inc.

US Patent


Assay Description
The in vitro activity of the compounds of the compounds of the invention may be determined by the following procedure. More particularly, the followi...


US Patent US10450297 (2019)


BindingDB Entry DOI: 10.7270/Q2T72KQP
More data for this
Ligand-Target Pair
Focal adhesion kinase 1 (FAK) (aa 410-689)


(Homo sapiens (Human))
BDBM418852
PNG
(N-[2-({[2-({4-[(1R)-1- aminoethyl]phenyl}amino)-5-...)
Show SMILES C[C@@H](N)c1ccc(Nc2ncc(c(NCc3ncccc3N(C)S(C)(=O)=O)n2)C(F)(F)F)cc1
Show InChI InChI=1S/C21H24F3N7O2S/c1-13(25)14-6-8-15(9-7-14)29-20-28-11-16(21(22,23)24)19(30-20)27-12-17-18(5-4-10-26-17)31(2)34(3,32)33/h4-11,13H,12,25H2,1-3H3,(H2,27,28,29,30)/t13-/m1/s1
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Pfizer, Inc.

US Patent


Assay Description
The in vitro activity of the compounds of the compounds of the invention may be determined by the following procedure. More particularly, the followi...


US Patent US10450297 (2019)


BindingDB Entry DOI: 10.7270/Q2T72KQP
More data for this
Ligand-Target Pair
Focal adhesion kinase 1 (FAK) (aa 410-689)


(Homo sapiens (Human))
BDBM418853
PNG
(N-[3-({[2-({4-[(1R)-1- aminoethyl]phenyl}amino)-5-...)
Show SMILES C[C@@H](N)c1ccc(Nc2ncc(c(NCc3cccc(c3)N(C)S(C)(=O)=O)n2)C(F)(F)F)cc1
Show InChI InChI=1S/C22H25F3N6O2S/c1-14(26)16-7-9-17(10-8-16)29-21-28-13-19(22(23,24)25)20(30-21)27-12-15-5-4-6-18(11-15)31(2)34(3,32)33/h4-11,13-14H,12,26H2,1-3H3,(H2,27,28,29,30)/t14-/m1/s1
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Pfizer, Inc.

US Patent


Assay Description
The in vitro activity of the compounds of the compounds of the invention may be determined by the following procedure. More particularly, the followi...


US Patent US10450297 (2019)


BindingDB Entry DOI: 10.7270/Q2T72KQP
More data for this
Ligand-Target Pair
Focal adhesion kinase 1 (FAK) (aa 410-689)


(Homo sapiens (Human))
BDBM418841
PNG
(3-methyl-4-({4-[({2- [methyl(methylsulfonyl)amino]...)
Show SMILES CN(c1ncccc1CNc1nc(Nc2ccc(cc2C)C(N)=O)ncc1C(F)(F)F)S(C)(=O)=O
Show InChI InChI=1S/C21H22F3N7O3S/c1-12-9-13(17(25)32)6-7-16(12)29-20-28-11-15(21(22,23)24)18(30-20)27-10-14-5-4-8-26-19(14)31(2)35(3,33)34/h4-9,11H,10H2,1-3H3,(H2,25,32)(H2,27,28,29,30)
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Pfizer, Inc.

US Patent


Assay Description
The in vitro activity of the compounds of the compounds of the invention may be determined by the following procedure. More particularly, the followi...


US Patent US10450297 (2019)


BindingDB Entry DOI: 10.7270/Q2T72KQP
More data for this
Ligand-Target Pair
Focal adhesion kinase 1 (FAK) (aa 410-689)


(Homo sapiens (Human))
BDBM418791
PNG
(N-methyl-N-{3-[({2-[(4-morpholin-4- ylphenyl)amino...)
Show SMILES CN(c1ncccc1CNc1nc(Nc2ccc(cc2)N2CCOCC2)ncc1C(F)(F)F)S(C)(=O)=O
Show InChI InChI=1S/C23H26F3N7O3S/c1-32(37(2,34)35)21-16(4-3-9-27-21)14-28-20-19(23(24,25)26)15-29-22(31-20)30-17-5-7-18(8-6-17)33-10-12-36-13-11-33/h3-9,15H,10-14H2,1-2H3,(H2,28,29,30,31)
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Pfizer, Inc.

US Patent


Assay Description
The in vitro activity of the compounds of the compounds of the invention may be determined by the following procedure. More particularly, the followi...


US Patent US10450297 (2019)


BindingDB Entry DOI: 10.7270/Q2T72KQP
More data for this
Ligand-Target Pair
Focal adhesion kinase 1 (FAK) (aa 410-689)


(Homo sapiens (Human))
BDBM418888
PNG
(N-{3-[({2-((4-{[(2- methoxyethyl)amino]methyl}phen...)
Show SMILES COCCNCc1ccc(Nc2ncc(c(NCc3cccnc3N(C)S(C)(=O)=O)n2)C(F)(F)F)cc1
Show InChI InChI=1S/C23H28F3N7O3S/c1-33(37(3,34)35)21-17(5-4-10-28-21)14-29-20-19(23(24,25)26)15-30-22(32-20)31-18-8-6-16(7-9-18)13-27-11-12-36-2/h4-10,15,27H,11-14H2,1-3H3,(H2,29,30,31,32)
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Pfizer, Inc.

US Patent


Assay Description
The in vitro activity of the compounds of the compounds of the invention may be determined by the following procedure. More particularly, the followi...


US Patent US10450297 (2019)


BindingDB Entry DOI: 10.7270/Q2T72KQP
More data for this
Ligand-Target Pair
Focal adhesion kinase 1 (FAK) (aa 410-689)


(Homo sapiens (Human))
BDBM418822
PNG
(3-fluoro-4-({4-[({2- [methyl(methylsulfonyl)amino]...)
Show SMILES CN(c1ncccc1CNc1nc(Nc2ccc(cc2F)C(N)=O)ncc1C(F)(F)F)S(C)(=O)=O
Show InChI InChI=1S/C20H19F4N7O3S/c1-31(35(2,33)34)18-12(4-3-7-26-18)9-27-17-13(20(22,23)24)10-28-19(30-17)29-15-6-5-11(16(25)32)8-14(15)21/h3-8,10H,9H2,1-2H3,(H2,25,32)(H2,27,28,29,30)
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Pfizer, Inc.

US Patent


Assay Description
The in vitro activity of the compounds of the compounds of the invention may be determined by the following procedure. More particularly, the followi...


US Patent US10450297 (2019)


BindingDB Entry DOI: 10.7270/Q2T72KQP
More data for this
Ligand-Target Pair
Focal adhesion kinase 1 (FAK) (aa 410-689)


(Homo sapiens (Human))
BDBM418840
PNG
(2-methyl-4-{[4-({3- [methyl(methylsulfonyl)amino]b...)
Show SMILES CN(c1cccc(CNc2nc(Nc3ccc(C(N)=O)c(C)c3)ncc2C(F)(F)F)c1)S(C)(=O)=O
Show InChI InChI=1S/C22H23F3N6O3S/c1-13-9-15(7-8-17(13)19(26)32)29-21-28-12-18(22(23,24)25)20(30-21)27-11-14-5-4-6-16(10-14)31(2)35(3,33)34/h4-10,12H,11H2,1-3H3,(H2,26,32)(H2,27,28,29,30)
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Pfizer, Inc.

US Patent


Assay Description
The in vitro activity of the compounds of the compounds of the invention may be determined by the following procedure. More particularly, the followi...


US Patent US10450297 (2019)


BindingDB Entry DOI: 10.7270/Q2T72KQP
More data for this
Ligand-Target Pair
Focal adhesion kinase 1 (FAK) (aa 410-689)


(Homo sapiens (Human))
BDBM418902
PNG
(N,2-dimethyl-4-({4-[({2- [methyl(methylsulfonyl)am...)
Show SMILES CNC(=O)c1ccc(Nc2ncc(c(NCc3cccnc3N(C)S(C)(=O)=O)n2)C(F)(F)F)cc1C
Show InChI InChI=1S/C22H24F3N7O3S/c1-13-10-15(7-8-16(13)20(33)26-2)30-21-29-12-17(22(23,24)25)18(31-21)28-11-14-6-5-9-27-19(14)32(3)36(4,34)35/h5-10,12H,11H2,1-4H3,(H,26,33)(H2,28,29,30,31)
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Pfizer, Inc.

US Patent


Assay Description
The in vitro activity of the compounds of the compounds of the invention may be determined by the following procedure. More particularly, the followi...


US Patent US10450297 (2019)


BindingDB Entry DOI: 10.7270/Q2T72KQP
More data for this
Ligand-Target Pair
Focal adhesion kinase 1 (FAK) (aa 410-689)


(Homo sapiens (Human))
BDBM418913
PNG
(N-{3-[({2-[(4-{[(2-hydroxy-2- methylpropyl)amino]m...)
Show SMILES CN(c1ncccc1CNc1nc(Nc2ccc(CNCC(C)(C)O)cc2)ncc1C(F)(F)F)S(C)(=O)=O
Show InChI InChI=1S/C24H30F3N7O3S/c1-23(2,35)15-28-12-16-7-9-18(10-8-16)32-22-31-14-19(24(25,26)27)20(33-22)30-13-17-6-5-11-29-21(17)34(3)38(4,36)37/h5-11,14,28,35H,12-13,15H2,1-4H3,(H2,30,31,32,33)
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Pfizer, Inc.

US Patent


Assay Description
The in vitro activity of the compounds of the compounds of the invention may be determined by the following procedure. More particularly, the followi...


US Patent US10450297 (2019)


BindingDB Entry DOI: 10.7270/Q2T72KQP
More data for this
Ligand-Target Pair
Focal adhesion kinase 1 (FAK) (aa 410-689)


(Homo sapiens (Human))
BDBM418884
PNG
(N-[3-({[2-({4- [(isopropylamino)methyl]phenyl}amin...)
Show SMILES CC(C)NCc1ccc(Nc2ncc(c(NCc3cccnc3N(C)S(C)(=O)=O)n2)C(F)(F)F)cc1
Show InChI InChI=1S/C23H28F3N7O2S/c1-15(2)28-12-16-7-9-18(10-8-16)31-22-30-14-19(23(24,25)26)20(32-22)29-13-17-6-5-11-27-21(17)33(3)36(4,34)35/h5-11,14-15,28H,12-13H2,1-4H3,(H2,29,30,31,32)
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Pfizer, Inc.

US Patent


Assay Description
The in vitro activity of the compounds of the compounds of the invention may be determined by the following procedure. More particularly, the followi...


US Patent US10450297 (2019)


BindingDB Entry DOI: 10.7270/Q2T72KQP
More data for this
Ligand-Target Pair
Focal adhesion kinase 1 (FAK) (aa 410-689)


(Homo sapiens (Human))
BDBM418883
PNG
(N-{3-[({2-[(4-{[(2- hydroxyethyl)amino]methyl}phen...)
Show SMILES CN(c1ncccc1CNc1nc(Nc2ccc(CNCCO)cc2)ncc1C(F)(F)F)S(C)(=O)=O
Show InChI InChI=1S/C22H26F3N7O3S/c1-32(36(2,34)35)20-16(4-3-9-27-20)13-28-19-18(22(23,24)25)14-29-21(31-19)30-17-7-5-15(6-8-17)12-26-10-11-33/h3-9,14,26,33H,10-13H2,1-2H3,(H2,28,29,30,31)
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Pfizer, Inc.

US Patent


Assay Description
The in vitro activity of the compounds of the compounds of the invention may be determined by the following procedure. More particularly, the followi...


US Patent US10450297 (2019)


BindingDB Entry DOI: 10.7270/Q2T72KQP
More data for this
Ligand-Target Pair
Focal adhesion kinase 1 (FAK) (aa 410-689)


(Homo sapiens (Human))
BDBM418834
PNG
(2-methyl-4-({4-[({2- [methyl(methylsulfonyl)amino]...)
Show SMILES CN(c1ncccc1CNc1nc(Nc2ccc(C(N)=O)c(C)c2)ncc1C(F)(F)F)S(C)(=O)=O
Show InChI InChI=1S/C21H22F3N7O3S/c1-12-9-14(6-7-15(12)17(25)32)29-20-28-11-16(21(22,23)24)18(30-20)27-10-13-5-4-8-26-19(13)31(2)35(3,33)34/h4-9,11H,10H2,1-3H3,(H2,25,32)(H2,27,28,29,30)
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n/an/a<0.595n/an/an/an/an/an/a



Pfizer, Inc.

US Patent


Assay Description
The in vitro activity of the compounds of the compounds of the invention may be determined by the following procedure. More particularly, the followi...


US Patent US10450297 (2019)


BindingDB Entry DOI: 10.7270/Q2T72KQP
More data for this
Ligand-Target Pair
Focal adhesion kinase 1 (FAK) (aa 410-689)


(Homo sapiens (Human))
BDBM418851
PNG
(N-[3-({[2-({4-[(1R)-1- aminoethyl]phenyl}amino)-5-...)
Show SMILES C[C@H](N)c1ccc(Nc2ncc(c(NCc3nccnc3N(C)S(C)(=O)=O)n2)C(F)(F)F)cc1
Show InChI InChI=1S/C20H23F3N8O2S/c1-12(24)13-4-6-14(7-5-13)29-19-28-10-15(20(21,22)23)17(30-19)27-11-16-18(26-9-8-25-16)31(2)34(3,32)33/h4-10,12H,11,24H2,1-3H3,(H2,27,28,29,30)/t12-/m0/s1
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Pfizer, Inc.

US Patent


Assay Description
The in vitro activity of the compounds of the compounds of the invention may be determined by the following procedure. More particularly, the followi...


US Patent US10450297 (2019)


BindingDB Entry DOI: 10.7270/Q2T72KQP
More data for this
Ligand-Target Pair
Focal adhesion kinase 1 (FAK) (aa 410-689)


(Homo sapiens (Human))
BDBM418914
PNG
(N-methyl-N-[3-({[2-({4- [(methylamino)methyl]pheny...)
Show SMILES CNCc1ccc(Nc2ncc(c(NCc3cccnc3N(C)S(C)(=O)=O)n2)C(F)(F)F)cc1
Show InChI InChI=1S/C21H24F3N7O2S/c1-25-11-14-6-8-16(9-7-14)29-20-28-13-17(21(22,23)24)18(30-20)27-12-15-5-4-10-26-19(15)31(2)34(3,32)33/h4-10,13,25H,11-12H2,1-3H3,(H2,27,28,29,30)
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n/an/a<0.595n/an/an/an/an/an/a



Pfizer, Inc.

US Patent


Assay Description
The in vitro activity of the compounds of the compounds of the invention may be determined by the following procedure. More particularly, the followi...


US Patent US10450297 (2019)


BindingDB Entry DOI: 10.7270/Q2T72KQP
More data for this
Ligand-Target Pair
Focal adhesion kinase 1 (FAK) (aa 410-689)


(Homo sapiens (Human))
BDBM418836
PNG
(2-methyl-4-({4-[({3- [methyl(methylsulfonyl)amino]...)
Show SMILES CN(c1cccnc1CNc1nc(Nc2ccc(C(N)=O)c(C)c2)ncc1C(F)(F)F)S(C)(=O)=O
Show InChI InChI=1S/C21H22F3N7O3S/c1-12-9-13(6-7-14(12)18(25)32)29-20-28-10-15(21(22,23)24)19(30-20)27-11-16-17(5-4-8-26-16)31(2)35(3,33)34/h4-10H,11H2,1-3H3,(H2,25,32)(H2,27,28,29,30)
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n/an/a<0.595n/an/an/an/an/an/a



Pfizer, Inc.

US Patent


Assay Description
The in vitro activity of the compounds of the compounds of the invention may be determined by the following procedure. More particularly, the followi...


US Patent US10450297 (2019)


BindingDB Entry DOI: 10.7270/Q2T72KQP
More data for this
Ligand-Target Pair
Focal adhesion kinase 1 (FAK) (aa 410-689)


(Homo sapiens (Human))
BDBM418834
PNG
(2-methyl-4-({4-[({2- [methyl(methylsulfonyl)amino]...)
Show SMILES CN(c1ncccc1CNc1nc(Nc2ccc(C(N)=O)c(C)c2)ncc1C(F)(F)F)S(C)(=O)=O
Show InChI InChI=1S/C21H22F3N7O3S/c1-12-9-14(6-7-15(12)17(25)32)29-20-28-11-16(21(22,23)24)18(30-20)27-10-13-5-4-8-26-19(13)31(2)35(3,33)34/h4-9,11H,10H2,1-3H3,(H2,25,32)(H2,27,28,29,30)
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n/an/a<0.595n/an/an/an/an/an/a



Pfizer, Inc.

US Patent


Assay Description
The in vitro activity of the compounds of the compounds of the invention may be determined by the following procedure. More particularly, the followi...


US Patent US10450297 (2019)


BindingDB Entry DOI: 10.7270/Q2T72KQP
More data for this
Ligand-Target Pair
Focal adhesion kinase 1 (FAK) (aa 410-689)


(Homo sapiens (Human))
BDBM418915
PNG
(N-methyl-N-[2-({[2-({4- [(methylamino)methyl]pheny...)
Show SMILES CNCc1ccc(Nc2ncc(c(NCc3ccccc3N(C)S(C)(=O)=O)n2)C(F)(F)F)cc1
Show InChI InChI=1S/C22H25F3N6O2S/c1-26-12-15-8-10-17(11-9-15)29-21-28-14-18(22(23,24)25)20(30-21)27-13-16-6-4-5-7-19(16)31(2)34(3,32)33/h4-11,14,26H,12-13H2,1-3H3,(H2,27,28,29,30)
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n/an/a<0.595n/an/an/an/an/an/a



Pfizer, Inc.

US Patent


Assay Description
The in vitro activity of the compounds of the compounds of the invention may be determined by the following procedure. More particularly, the followi...


US Patent US10450297 (2019)


BindingDB Entry DOI: 10.7270/Q2T72KQP
More data for this
Ligand-Target Pair
Focal adhesion kinase 1 (FAK) (aa 410-689)


(Homo sapiens (Human))
BDBM418793
PNG
(N-methyl-N-{3-[({2-[(5-morpholin-4- ylpyridin-2-yl...)
Show SMILES CN(c1ncccc1CNc1nc(Nc2ccc(cn2)N2CCOCC2)ncc1C(F)(F)F)S(C)(=O)=O
Show InChI InChI=1S/C22H25F3N8O3S/c1-32(37(2,34)35)20-15(4-3-7-26-20)12-28-19-17(22(23,24)25)14-29-21(31-19)30-18-6-5-16(13-27-18)33-8-10-36-11-9-33/h3-7,13-14H,8-12H2,1-2H3,(H2,27,28,29,30,31)
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n/an/a<0.595n/an/an/an/an/an/a



Pfizer, Inc.

US Patent


Assay Description
The in vitro activity of the compounds of the compounds of the invention may be determined by the following procedure. More particularly, the followi...


US Patent US10450297 (2019)


BindingDB Entry DOI: 10.7270/Q2T72KQP
More data for this
Ligand-Target Pair
Focal adhesion kinase 1 (FAK) (aa 410-689)


(Homo sapiens (Human))
BDBM418794
PNG
(3-({4-[({6-methyl-2- [methyl(methylsulfonyl)amino]...)
Show SMILES CN(c1nc(C)ccc1CNc1nc(Nc2cccc(c2)C(N)=O)ncc1C(F)(F)F)S(C)(=O)=O
Show InChI InChI=1S/C21H22F3N7O3S/c1-12-7-8-14(19(28-12)31(2)35(3,33)34)10-26-18-16(21(22,23)24)11-27-20(30-18)29-15-6-4-5-13(9-15)17(25)32/h4-9,11H,10H2,1-3H3,(H2,25,32)(H2,26,27,29,30)
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n/an/a<0.595n/an/an/an/an/an/a



Pfizer, Inc.

US Patent


Assay Description
The in vitro activity of the compounds of the compounds of the invention may be determined by the following procedure. More particularly, the followi...


US Patent US10450297 (2019)


BindingDB Entry DOI: 10.7270/Q2T72KQP
More data for this
Ligand-Target Pair
Focal adhesion kinase 1 (FAK) (aa 410-689)


(Homo sapiens (Human))
BDBM418801
PNG
(N-[3-({[2-{[3-(1- hydroxyethyl)phenyl]amino}-5- (t...)
Show SMILES CC(O)c1cccc(Nc2ncc(c(NCc3cccnc3N(C)S(C)(=O)=O)n2)C(F)(F)F)n1
Show InChI InChI=1S/C20H22F3N7O3S/c1-12(31)15-7-4-8-16(27-15)28-19-26-11-14(20(21,22)23)17(29-19)25-10-13-6-5-9-24-18(13)30(2)34(3,32)33/h4-9,11-12,31H,10H2,1-3H3,(H2,25,26,27,28,29)
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n/an/a<0.595n/an/an/an/an/an/a



Pfizer, Inc.

US Patent


Assay Description
The in vitro activity of the compounds of the compounds of the invention may be determined by the following procedure. More particularly, the followi...


US Patent US10450297 (2019)


BindingDB Entry DOI: 10.7270/Q2T72KQP
More data for this
Ligand-Target Pair
Focal adhesion kinase 1 (FAK) (aa 410-689)


(Homo sapiens (Human))
BDBM418838
PNG
(2-methyl-4-({4-[({3- [methyl(methylsulfonyl)amino]...)
Show SMILES CN(c1nccnc1CNc1nc(Nc2ccc(C(N)=O)c(C)c2)ncc1C(F)(F)F)S(C)(=O)=O
Show InChI InChI=1S/C20H21F3N8O3S/c1-11-8-12(4-5-13(11)16(24)32)29-19-28-9-14(20(21,22)23)17(30-19)27-10-15-18(26-7-6-25-15)31(2)35(3,33)34/h4-9H,10H2,1-3H3,(H2,24,32)(H2,27,28,29,30)
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n/an/a<0.595n/an/an/an/an/an/a



Pfizer, Inc.

US Patent


Assay Description
The in vitro activity of the compounds of the compounds of the invention may be determined by the following procedure. More particularly, the followi...


US Patent US10450297 (2019)


BindingDB Entry DOI: 10.7270/Q2T72KQP
More data for this
Ligand-Target Pair
Focal adhesion kinase 1 (FAK) (aa 410-689)


(Homo sapiens (Human))
BDBM418849
PNG
(N-methyl-N-[3-({[2-{[4-(morpholin-4- ylmethyl)phen...)
Show SMILES CN(c1ncccc1CNc1nc(Nc2ccc(CN3CCOCC3)cc2)ncc1C(F)(F)F)S(C)(=O)=O
Show InChI InChI=1S/C24H28F3N7O3S/c1-33(38(2,35)36)22-18(4-3-9-28-22)14-29-21-20(24(25,26)27)15-30-23(32-21)31-19-7-5-17(6-8-19)16-34-10-12-37-13-11-34/h3-9,15H,10-14,16H2,1-2H3,(H2,29,30,31,32)
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n/an/a<0.595n/an/an/an/an/an/a



Pfizer, Inc.

US Patent


Assay Description
The in vitro activity of the compounds of the compounds of the invention may be determined by the following procedure. More particularly, the followi...


US Patent US10450297 (2019)


BindingDB Entry DOI: 10.7270/Q2T72KQP
More data for this
Ligand-Target Pair
Focal adhesion kinase 1 (FAK) (aa 410-689)


(Homo sapiens (Human))
BDBM418860
PNG
(2-chloro-4-({4-[({3- [methyl(methylsulfonyl)amino]...)
Show SMILES CN(c1nccnc1CNc1nc(Nc2ccc(C(N)=O)c(Cl)c2)ncc1C(F)(F)F)S(C)(=O)=O
Show InChI InChI=1S/C19H18ClF3N8O3S/c1-31(35(2,33)34)17-14(25-5-6-26-17)9-27-16-12(19(21,22)23)8-28-18(30-16)29-10-3-4-11(15(24)32)13(20)7-10/h3-8H,9H2,1-2H3,(H2,24,32)(H2,27,28,29,30)
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n/an/a<0.595n/an/an/an/an/an/a



Pfizer, Inc.

US Patent


Assay Description
The in vitro activity of the compounds of the compounds of the invention may be determined by the following procedure. More particularly, the followi...


US Patent US10450297 (2019)


BindingDB Entry DOI: 10.7270/Q2T72KQP
More data for this
Ligand-Target Pair
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* indicates data uncertainty>20%