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Patent code US10450301

Compile Data Set for Download or QSAR
Found 191 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM419108
PNG
(US10450301, Example 187)
Show SMILES CCn1cc(CNC(=O)N2CCc3cnc(cc3C2)C(=O)Nc2cccc(n2)-c2nnnn2[C@H](C)CO)cn1
Show InChI InChI=1S/C25H29N11O3/c1-3-35-13-17(11-28-35)10-27-25(39)34-8-7-18-12-26-21(9-19(18)14-34)24(38)30-22-6-4-5-20(29-22)23-31-32-33-36(23)16(2)15-37/h4-6,9,11-13,16,37H,3,7-8,10,14-15H2,1-2H3,(H,27,39)(H,29,30,38)/t16-/m1/s1
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Enanta Pharmaceuticals, Inc.

US Patent


Assay Description
HTRF KinEASE-STK is a generic method for measuring serine/threonine kinase activities using a time-resolved fluorescence resonance energy transfer (T...


US Patent US10450301 (2019)


BindingDB Entry DOI: 10.7270/Q2P84F7M
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM419047
PNG
(US10450301, Example 126)
Show SMILES C[C@H](CO)n1nnnc1-c1cccc(NC(=O)c2cc3CN(CCc3cn2)C(=O)OCC(F)(F)F)n1
Show InChI InChI=1S/C21H21F3N8O4/c1-12(10-33)32-18(28-29-30-32)15-3-2-4-17(26-15)27-19(34)16-7-14-9-31(6-5-13(14)8-25-16)20(35)36-11-21(22,23)24/h2-4,7-8,12,33H,5-6,9-11H2,1H3,(H,26,27,34)/t12-/m1/s1
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Enanta Pharmaceuticals, Inc.

US Patent


Assay Description
HTRF KinEASE-STK is a generic method for measuring serine/threonine kinase activities using a time-resolved fluorescence resonance energy transfer (T...


US Patent US10450301 (2019)


BindingDB Entry DOI: 10.7270/Q2P84F7M
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM418984
PNG
(US10450301, Example 63)
Show SMILES CCNC(=O)N1CCc2ccc(cc2C1)C(=O)Nc1cccc(n1)-c1nncn1C(C)C
Show InChI InChI=1S/C23H27N7O2/c1-4-24-23(32)29-11-10-16-8-9-17(12-18(16)13-29)22(31)27-20-7-5-6-19(26-20)21-28-25-14-30(21)15(2)3/h5-9,12,14-15H,4,10-11,13H2,1-3H3,(H,24,32)(H,26,27,31)
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Enanta Pharmaceuticals, Inc.

US Patent


Assay Description
HTRF KinEASE-STK is a generic method for measuring serine/threonine kinase activities using a time-resolved fluorescence resonance energy transfer (T...


US Patent US10450301 (2019)


BindingDB Entry DOI: 10.7270/Q2P84F7M
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM419043
PNG
(US10450301, Example 122)
Show SMILES COCCC(=O)N1CCc2cnc(cc2C1)C(=O)Nc1cccc(n1)-c1nnnn1[C@H](C)CO
Show InChI InChI=1S/C22H26N8O4/c1-14(13-31)30-21(26-27-28-30)17-4-3-5-19(24-17)25-22(33)18-10-16-12-29(20(32)7-9-34-2)8-6-15(16)11-23-18/h3-5,10-11,14,31H,6-9,12-13H2,1-2H3,(H,24,25,33)/t14-/m1/s1
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Enanta Pharmaceuticals, Inc.

US Patent


Assay Description
HTRF KinEASE-STK is a generic method for measuring serine/threonine kinase activities using a time-resolved fluorescence resonance energy transfer (T...


US Patent US10450301 (2019)


BindingDB Entry DOI: 10.7270/Q2P84F7M
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM419066
PNG
(US10450301, Example 145)
Show SMILES CCOC(=O)N1CCc2cnc(cc2C1)C(=O)Nc1cccc(n1)-c1nnnn1[C@H](C)CO
Show InChI InChI=1S/C21H24N8O4/c1-3-33-21(32)28-8-7-14-10-22-17(9-15(14)11-28)20(31)24-18-6-4-5-16(23-18)19-25-26-27-29(19)13(2)12-30/h4-6,9-10,13,30H,3,7-8,11-12H2,1-2H3,(H,23,24,31)/t13-/m1/s1
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Enanta Pharmaceuticals, Inc.

US Patent


Assay Description
HTRF KinEASE-STK is a generic method for measuring serine/threonine kinase activities using a time-resolved fluorescence resonance energy transfer (T...


US Patent US10450301 (2019)


BindingDB Entry DOI: 10.7270/Q2P84F7M
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM419069
PNG
(US10450301, Example 148)
Show SMILES C[C@H](CO)n1nnnc1-c1cccc(NC(=O)c2cc3CN(CCc3cn2)S(=O)(=O)C2CC2)n1
Show InChI InChI=1S/C21H24N8O4S/c1-13(12-30)29-20(25-26-27-29)17-3-2-4-19(23-17)24-21(31)18-9-15-11-28(8-7-14(15)10-22-18)34(32,33)16-5-6-16/h2-4,9-10,13,16,30H,5-8,11-12H2,1H3,(H,23,24,31)/t13-/m1/s1
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Enanta Pharmaceuticals, Inc.

US Patent


Assay Description
HTRF KinEASE-STK is a generic method for measuring serine/threonine kinase activities using a time-resolved fluorescence resonance energy transfer (T...


US Patent US10450301 (2019)


BindingDB Entry DOI: 10.7270/Q2P84F7M
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM419070
PNG
(US10450301, Example 149)
Show SMILES CC(C)S(=O)(=O)N1CCc2cnc(cc2C1)C(=O)Nc1cccc(n1)-c1nnnn1[C@H](C)CO
Show InChI InChI=1S/C21H26N8O4S/c1-13(2)34(32,33)28-8-7-15-10-22-18(9-16(15)11-28)21(31)24-19-6-4-5-17(23-19)20-25-26-27-29(20)14(3)12-30/h4-6,9-10,13-14,30H,7-8,11-12H2,1-3H3,(H,23,24,31)/t14-/m1/s1
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Enanta Pharmaceuticals, Inc.

US Patent


Assay Description
HTRF KinEASE-STK is a generic method for measuring serine/threonine kinase activities using a time-resolved fluorescence resonance energy transfer (T...


US Patent US10450301 (2019)


BindingDB Entry DOI: 10.7270/Q2P84F7M
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM419071
PNG
(US10450301, Example 150)
Show SMILES C[C@H](CO)n1nnnc1-c1cccc(NC(=O)c2cc3CN(CCc3cn2)S(=O)(=O)CCC(F)(F)F)n1
Show InChI InChI=1S/C21H23F3N8O4S/c1-13(12-33)32-19(28-29-30-32)16-3-2-4-18(26-16)27-20(34)17-9-15-11-31(7-5-14(15)10-25-17)37(35,36)8-6-21(22,23)24/h2-4,9-10,13,33H,5-8,11-12H2,1H3,(H,26,27,34)/t13-/m1/s1
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Enanta Pharmaceuticals, Inc.

US Patent


Assay Description
HTRF KinEASE-STK is a generic method for measuring serine/threonine kinase activities using a time-resolved fluorescence resonance energy transfer (T...


US Patent US10450301 (2019)


BindingDB Entry DOI: 10.7270/Q2P84F7M
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM419075
PNG
(US10450301, Example 154)
Show SMILES C[C@H](CO)n1nnnc1-c1cccc(NC(=O)c2cc3CN(CCc3cn2)S(=O)(=O)N2CCCC2)n1
Show InChI InChI=1S/C22H27N9O4S/c1-15(14-32)31-21(26-27-28-31)18-5-4-6-20(24-18)25-22(33)19-11-17-13-30(10-7-16(17)12-23-19)36(34,35)29-8-2-3-9-29/h4-6,11-12,15,32H,2-3,7-10,13-14H2,1H3,(H,24,25,33)/t15-/m1/s1
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Enanta Pharmaceuticals, Inc.

US Patent


Assay Description
HTRF KinEASE-STK is a generic method for measuring serine/threonine kinase activities using a time-resolved fluorescence resonance energy transfer (T...


US Patent US10450301 (2019)


BindingDB Entry DOI: 10.7270/Q2P84F7M
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM419090
PNG
(US10450301, Example 169)
Show SMILES C[C@H](CO)n1nnnc1-c1cccc(NC(=O)c2cc3CN(CCc3cn2)C(=O)NC2CCCC2)n1
Show InChI InChI=1S/C24H29N9O3/c1-15(14-34)33-22(29-30-31-33)19-7-4-8-21(27-19)28-23(35)20-11-17-13-32(10-9-16(17)12-25-20)24(36)26-18-5-2-3-6-18/h4,7-8,11-12,15,18,34H,2-3,5-6,9-10,13-14H2,1H3,(H,26,36)(H,27,28,35)/t15-/m1/s1
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Enanta Pharmaceuticals, Inc.

US Patent


Assay Description
HTRF KinEASE-STK is a generic method for measuring serine/threonine kinase activities using a time-resolved fluorescence resonance energy transfer (T...


US Patent US10450301 (2019)


BindingDB Entry DOI: 10.7270/Q2P84F7M
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM419093
PNG
(US10450301, Example 172)
Show SMILES CC(C)n1nnnc1-c1cccc(NC(=O)c2cc3CN(CCc3cn2)S(=O)(=O)CCC(F)(F)F)n1
Show InChI InChI=1S/C21H23F3N8O3S/c1-13(2)32-19(28-29-30-32)16-4-3-5-18(26-16)27-20(33)17-10-15-12-31(8-6-14(15)11-25-17)36(34,35)9-7-21(22,23)24/h3-5,10-11,13H,6-9,12H2,1-2H3,(H,26,27,33)
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Enanta Pharmaceuticals, Inc.

US Patent


Assay Description
HTRF KinEASE-STK is a generic method for measuring serine/threonine kinase activities using a time-resolved fluorescence resonance energy transfer (T...


US Patent US10450301 (2019)


BindingDB Entry DOI: 10.7270/Q2P84F7M
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM418962
PNG
(US10450301, Example 41)
Show SMILES CCN(CC)C(=O)N1CCc2cc(F)c(cc2C1)C(=O)Nc1cccc(n1)-c1nncn1C(C)C
Show InChI InChI=1S/C25H30FN7O2/c1-5-31(6-2)25(35)32-11-10-17-13-20(26)19(12-18(17)14-32)24(34)29-22-9-7-8-21(28-22)23-30-27-15-33(23)16(3)4/h7-9,12-13,15-16H,5-6,10-11,14H2,1-4H3,(H,28,29,34)
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Enanta Pharmaceuticals, Inc.

US Patent


Assay Description
HTRF KinEASE-STK is a generic method for measuring serine/threonine kinase activities using a time-resolved fluorescence resonance energy transfer (T...


US Patent US10450301 (2019)


BindingDB Entry DOI: 10.7270/Q2P84F7M
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM419039
PNG
(US10450301, Example 118)
Show SMILES CCOC(=O)N1CCc2cnc(cc2C1)C(=O)Nc1cccc(n1)-c1nnnn1C(C)C
Show InChI InChI=1S/C21H24N8O3/c1-4-32-21(31)28-9-8-14-11-22-17(10-15(14)12-28)20(30)24-18-7-5-6-16(23-18)19-25-26-27-29(19)13(2)3/h5-7,10-11,13H,4,8-9,12H2,1-3H3,(H,23,24,30)
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Enanta Pharmaceuticals, Inc.

US Patent


Assay Description
HTRF KinEASE-STK is a generic method for measuring serine/threonine kinase activities using a time-resolved fluorescence resonance energy transfer (T...


US Patent US10450301 (2019)


BindingDB Entry DOI: 10.7270/Q2P84F7M
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM419044
PNG
(US10450301, Example 123)
Show SMILES C[C@H](CO)n1nnnc1-c1cccc(NC(=O)c2cc3CN(CCc3cn2)C(=O)CCC(F)(F)F)n1
Show InChI InChI=1S/C22H23F3N8O3/c1-13(12-34)33-20(29-30-31-33)16-3-2-4-18(27-16)28-21(36)17-9-15-11-32(8-6-14(15)10-26-17)19(35)5-7-22(23,24)25/h2-4,9-10,13,34H,5-8,11-12H2,1H3,(H,27,28,36)/t13-/m1/s1
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Enanta Pharmaceuticals, Inc.

US Patent


Assay Description
HTRF KinEASE-STK is a generic method for measuring serine/threonine kinase activities using a time-resolved fluorescence resonance energy transfer (T...


US Patent US10450301 (2019)


BindingDB Entry DOI: 10.7270/Q2P84F7M
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM419067
PNG
(US10450301, Example 146)
Show SMILES C[C@H](CO)n1nnnc1-c1cccc(NC(=O)c2cc3CN(CCc3cn2)C(=O)C2CCCC2)n1
Show InChI InChI=1S/C24H28N8O3/c1-15(14-33)32-22(28-29-30-32)19-7-4-8-21(26-19)27-23(34)20-11-18-13-31(10-9-17(18)12-25-20)24(35)16-5-2-3-6-16/h4,7-8,11-12,15-16,33H,2-3,5-6,9-10,13-14H2,1H3,(H,26,27,34)/t15-/m1/s1
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Enanta Pharmaceuticals, Inc.

US Patent


Assay Description
HTRF KinEASE-STK is a generic method for measuring serine/threonine kinase activities using a time-resolved fluorescence resonance energy transfer (T...


US Patent US10450301 (2019)


BindingDB Entry DOI: 10.7270/Q2P84F7M
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM419077
PNG
(US10450301, Example 156)
Show SMILES C[C@H](CO)n1nnnc1-c1cccc(NC(=O)c2cc3CN(CCc3cn2)C(=O)OC2CCCC2)n1
Show InChI InChI=1S/C24H28N8O4/c1-15(14-33)32-22(28-29-30-32)19-7-4-8-21(26-19)27-23(34)20-11-17-13-31(10-9-16(17)12-25-20)24(35)36-18-5-2-3-6-18/h4,7-8,11-12,15,18,33H,2-3,5-6,9-10,13-14H2,1H3,(H,26,27,34)/t15-/m1/s1
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Enanta Pharmaceuticals, Inc.

US Patent


Assay Description
HTRF KinEASE-STK is a generic method for measuring serine/threonine kinase activities using a time-resolved fluorescence resonance energy transfer (T...


US Patent US10450301 (2019)


BindingDB Entry DOI: 10.7270/Q2P84F7M
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM419079
PNG
(US10450301, Example 158)
Show SMILES COCCOC(=O)N1CCc2cnc(cc2C1)C(=O)Nc1cccc(n1)-c1nnnn1[C@H](C)CO
Show InChI InChI=1S/C22H26N8O5/c1-14(13-31)30-20(26-27-28-30)17-4-3-5-19(24-17)25-21(32)18-10-16-12-29(7-6-15(16)11-23-18)22(33)35-9-8-34-2/h3-5,10-11,14,31H,6-9,12-13H2,1-2H3,(H,24,25,32)/t14-/m1/s1
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Enanta Pharmaceuticals, Inc.

US Patent


Assay Description
HTRF KinEASE-STK is a generic method for measuring serine/threonine kinase activities using a time-resolved fluorescence resonance energy transfer (T...


US Patent US10450301 (2019)


BindingDB Entry DOI: 10.7270/Q2P84F7M
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM419082
PNG
(US10450301, Example 161)
Show SMILES CC(C)CS(=O)(=O)N1CCc2cnc(cc2C1)C(=O)Nc1cccc(n1)-c1nnnn1[C@H](C)CO
Show InChI InChI=1S/C22H28N8O4S/c1-14(2)13-35(33,34)29-8-7-16-10-23-19(9-17(16)11-29)22(32)25-20-6-4-5-18(24-20)21-26-27-28-30(21)15(3)12-31/h4-6,9-10,14-15,31H,7-8,11-13H2,1-3H3,(H,24,25,32)/t15-/m1/s1
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Enanta Pharmaceuticals, Inc.

US Patent


Assay Description
HTRF KinEASE-STK is a generic method for measuring serine/threonine kinase activities using a time-resolved fluorescence resonance energy transfer (T...


US Patent US10450301 (2019)


BindingDB Entry DOI: 10.7270/Q2P84F7M
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM419104
PNG
(US10450301, Example 183)
Show SMILES C[C@H](CO)n1nnnc1-c1cccc(NC(=O)c2cc3CN(CCc3cn2)C(=O)NCCC(F)(F)F)n1
Show InChI InChI=1S/C22H24F3N9O3/c1-13(12-35)34-19(30-31-32-34)16-3-2-4-18(28-16)29-20(36)17-9-15-11-33(8-5-14(15)10-27-17)21(37)26-7-6-22(23,24)25/h2-4,9-10,13,35H,5-8,11-12H2,1H3,(H,26,37)(H,28,29,36)/t13-/m1/s1
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US Patent


Assay Description
HTRF KinEASE-STK is a generic method for measuring serine/threonine kinase activities using a time-resolved fluorescence resonance energy transfer (T...


US Patent US10450301 (2019)


BindingDB Entry DOI: 10.7270/Q2P84F7M
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM418941
PNG
(US10450301, Example 20)
Show SMILES CC(C)n1cnnc1-c1cccc(NC(=O)c2cc3CN(CCc3cc2F)S(=O)(=O)NC2CC2)n1
Show InChI InChI=1S/C23H26FN7O3S/c1-14(2)31-13-25-28-22(31)20-4-3-5-21(26-20)27-23(32)18-10-16-12-30(9-8-15(16)11-19(18)24)35(33,34)29-17-6-7-17/h3-5,10-11,13-14,17,29H,6-9,12H2,1-2H3,(H,26,27,32)
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Enanta Pharmaceuticals, Inc.

US Patent


Assay Description
HTRF KinEASE-STK is a generic method for measuring serine/threonine kinase activities using a time-resolved fluorescence resonance energy transfer (T...


US Patent US10450301 (2019)


BindingDB Entry DOI: 10.7270/Q2P84F7M
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM418945
PNG
(US10450301, Example 24)
Show SMILES COCCC(=O)N1CCc2cc(F)c(cc2C1)C(=O)Nc1cccc(n1)-c1nncn1C(C)C
Show InChI InChI=1S/C24H27FN6O3/c1-15(2)31-14-26-29-23(31)20-5-4-6-21(27-20)28-24(33)18-11-17-13-30(22(32)8-10-34-3)9-7-16(17)12-19(18)25/h4-6,11-12,14-15H,7-10,13H2,1-3H3,(H,27,28,33)
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Enanta Pharmaceuticals, Inc.

US Patent


Assay Description
HTRF KinEASE-STK is a generic method for measuring serine/threonine kinase activities using a time-resolved fluorescence resonance energy transfer (T...


US Patent US10450301 (2019)


BindingDB Entry DOI: 10.7270/Q2P84F7M
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM418973
PNG
(US10450301, Example 52)
Show SMILES CCNC(=O)N1CCc2cc(F)c(cc2C1)C(=O)Nc1cccc(n1)-c1nncn1C(C)C
Show InChI InChI=1S/C23H26FN7O2/c1-4-25-23(33)30-9-8-15-11-18(24)17(10-16(15)12-30)22(32)28-20-7-5-6-19(27-20)21-29-26-13-31(21)14(2)3/h5-7,10-11,13-14H,4,8-9,12H2,1-3H3,(H,25,33)(H,27,28,32)
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Enanta Pharmaceuticals, Inc.

US Patent


Assay Description
HTRF KinEASE-STK is a generic method for measuring serine/threonine kinase activities using a time-resolved fluorescence resonance energy transfer (T...


US Patent US10450301 (2019)


BindingDB Entry DOI: 10.7270/Q2P84F7M
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM419003
PNG
(US10450301, Example 82)
Show SMILES C[C@H](CO)n1nnnc1-c1cccc(NC(=O)c2cc3CN(CCc3cc2F)S(=O)(=O)CCC(F)(F)F)n1
Show InChI InChI=1S/C22H23F4N7O4S/c1-13(12-34)33-20(29-30-31-33)18-3-2-4-19(27-18)28-21(35)16-9-15-11-32(7-5-14(15)10-17(16)23)38(36,37)8-6-22(24,25)26/h2-4,9-10,13,34H,5-8,11-12H2,1H3,(H,27,28,35)/t13-/m1/s1
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Enanta Pharmaceuticals, Inc.

US Patent


Assay Description
HTRF KinEASE-STK is a generic method for measuring serine/threonine kinase activities using a time-resolved fluorescence resonance energy transfer (T...


US Patent US10450301 (2019)


BindingDB Entry DOI: 10.7270/Q2P84F7M
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM419034
PNG
(US10450301, Example 113)
Show SMILES CCN(CC)C(=O)N1CCc2cnc(cc2C1)C(=O)Nc1cccc(n1)-c1nnnn1C(C)C
Show InChI InChI=1S/C23H29N9O2/c1-5-30(6-2)23(34)31-11-10-16-13-24-19(12-17(16)14-31)22(33)26-20-9-7-8-18(25-20)21-27-28-29-32(21)15(3)4/h7-9,12-13,15H,5-6,10-11,14H2,1-4H3,(H,25,26,33)
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Enanta Pharmaceuticals, Inc.

US Patent


Assay Description
HTRF KinEASE-STK is a generic method for measuring serine/threonine kinase activities using a time-resolved fluorescence resonance energy transfer (T...


US Patent US10450301 (2019)


BindingDB Entry DOI: 10.7270/Q2P84F7M
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM419036
PNG
(US10450301, Example 115)
Show SMILES CCN(C)C(=O)N1CCc2cnc(cc2C1)C(=O)Nc1cccc(n1)-c1nnnn1C(C)C
Show InChI InChI=1S/C22H27N9O2/c1-5-29(4)22(33)30-10-9-15-12-23-18(11-16(15)13-30)21(32)25-19-8-6-7-17(24-19)20-26-27-28-31(20)14(2)3/h6-8,11-12,14H,5,9-10,13H2,1-4H3,(H,24,25,32)
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Enanta Pharmaceuticals, Inc.

US Patent


Assay Description
HTRF KinEASE-STK is a generic method for measuring serine/threonine kinase activities using a time-resolved fluorescence resonance energy transfer (T...


US Patent US10450301 (2019)


BindingDB Entry DOI: 10.7270/Q2P84F7M
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM419046
PNG
(US10450301, Example 125)
Show SMILES CCC(=O)N1CCc2cnc(cc2C1)C(=O)Nc1cccc(n1)-c1nnnn1[C@H](C)CO
Show InChI InChI=1S/C21H24N8O3/c1-3-19(31)28-8-7-14-10-22-17(9-15(14)11-28)21(32)24-18-6-4-5-16(23-18)20-25-26-27-29(20)13(2)12-30/h4-6,9-10,13,30H,3,7-8,11-12H2,1-2H3,(H,23,24,32)/t13-/m1/s1
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Enanta Pharmaceuticals, Inc.

US Patent


Assay Description
HTRF KinEASE-STK is a generic method for measuring serine/threonine kinase activities using a time-resolved fluorescence resonance energy transfer (T...


US Patent US10450301 (2019)


BindingDB Entry DOI: 10.7270/Q2P84F7M
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM419052
PNG
(US10450301, Example 131)
Show SMILES C[C@H](CO)n1nnnc1-c1cccc(NC(=O)c2cc3CN(CCc3cn2)C(=O)NC2CC2)n1
Show InChI InChI=1S/C22H25N9O3/c1-13(12-32)31-20(27-28-29-31)17-3-2-4-19(25-17)26-21(33)18-9-15-11-30(8-7-14(15)10-23-18)22(34)24-16-5-6-16/h2-4,9-10,13,16,32H,5-8,11-12H2,1H3,(H,24,34)(H,25,26,33)/t13-/m1/s1
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Enanta Pharmaceuticals, Inc.

US Patent


Assay Description
HTRF KinEASE-STK is a generic method for measuring serine/threonine kinase activities using a time-resolved fluorescence resonance energy transfer (T...


US Patent US10450301 (2019)


BindingDB Entry DOI: 10.7270/Q2P84F7M
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM419058
PNG
(US10450301, Example 137)
Show SMILES CC(C)n1nnnc1-c1cccc(NC(=O)c2cc3CN(CCc3cn2)C(=O)N2CCS(=O)(=O)CC2)n1
Show InChI InChI=1S/C23H27N9O4S/c1-15(2)32-21(27-28-29-32)18-4-3-5-20(25-18)26-22(33)19-12-17-14-31(7-6-16(17)13-24-19)23(34)30-8-10-37(35,36)11-9-30/h3-5,12-13,15H,6-11,14H2,1-2H3,(H,25,26,33)
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Enanta Pharmaceuticals, Inc.

US Patent


Assay Description
HTRF KinEASE-STK is a generic method for measuring serine/threonine kinase activities using a time-resolved fluorescence resonance energy transfer (T...


US Patent US10450301 (2019)


BindingDB Entry DOI: 10.7270/Q2P84F7M
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM419065
PNG
(US10450301, Example 144)
Show SMILES C[C@H](CO)n1nnnc1-c1cccc(NC(=O)c2cc3CN(CCc3cn2)C(=O)N2CCCC2)n1
Show InChI InChI=1S/C23H27N9O3/c1-15(14-33)32-21(27-28-29-32)18-5-4-6-20(25-18)26-22(34)19-11-17-13-31(10-7-16(17)12-24-19)23(35)30-8-2-3-9-30/h4-6,11-12,15,33H,2-3,7-10,13-14H2,1H3,(H,25,26,34)/t15-/m1/s1
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Enanta Pharmaceuticals, Inc.

US Patent


Assay Description
HTRF KinEASE-STK is a generic method for measuring serine/threonine kinase activities using a time-resolved fluorescence resonance energy transfer (T...


US Patent US10450301 (2019)


BindingDB Entry DOI: 10.7270/Q2P84F7M
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM418947
PNG
(US10450301, Example 26)
Show SMILES CCOC(=O)N1CCc2cc(F)c(cc2C1)C(=O)Nc1cccc(n1)-c1nncn1C(C)C
Show InChI InChI=1S/C23H25FN6O3/c1-4-33-23(32)29-9-8-15-11-18(24)17(10-16(15)12-29)22(31)27-20-7-5-6-19(26-20)21-28-25-13-30(21)14(2)3/h5-7,10-11,13-14H,4,8-9,12H2,1-3H3,(H,26,27,31)
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Enanta Pharmaceuticals, Inc.

US Patent


Assay Description
HTRF KinEASE-STK is a generic method for measuring serine/threonine kinase activities using a time-resolved fluorescence resonance energy transfer (T...


US Patent US10450301 (2019)


BindingDB Entry DOI: 10.7270/Q2P84F7M
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM418965
PNG
(US10450301, Example 44)
Show SMILES CC(C)n1cnnc1-c1cccc(NC(=O)c2cc3CN(CCc3cc2F)C(=O)N2CCCC2)n1
Show InChI InChI=1S/C25H28FN7O2/c1-16(2)33-15-27-30-23(33)21-6-5-7-22(28-21)29-24(34)19-12-18-14-32(11-8-17(18)13-20(19)26)25(35)31-9-3-4-10-31/h5-7,12-13,15-16H,3-4,8-11,14H2,1-2H3,(H,28,29,34)
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Enanta Pharmaceuticals, Inc.

US Patent


Assay Description
HTRF KinEASE-STK is a generic method for measuring serine/threonine kinase activities using a time-resolved fluorescence resonance energy transfer (T...


US Patent US10450301 (2019)


BindingDB Entry DOI: 10.7270/Q2P84F7M
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM418972
PNG
(US10450301, Example 51)
Show SMILES CC(C)n1cnnc1-c1cccc(NC(=O)c2cc3CN(CCc3cc2F)C(=O)NC2CCCC2)n1
Show InChI InChI=1S/C26H30FN7O2/c1-16(2)34-15-28-32-24(34)22-8-5-9-23(30-22)31-25(35)20-12-18-14-33(11-10-17(18)13-21(20)27)26(36)29-19-6-3-4-7-19/h5,8-9,12-13,15-16,19H,3-4,6-7,10-11,14H2,1-2H3,(H,29,36)(H,30,31,35)
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Enanta Pharmaceuticals, Inc.

US Patent


Assay Description
HTRF KinEASE-STK is a generic method for measuring serine/threonine kinase activities using a time-resolved fluorescence resonance energy transfer (T...


US Patent US10450301 (2019)


BindingDB Entry DOI: 10.7270/Q2P84F7M
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM418997
PNG
(US10450301, Example 76)
Show SMILES C[C@H](CO)n1nnnc1-c1cccc(NC(=O)c2cc3CN(CCc3cc2F)C(=O)N2CCCC2)n1
Show InChI InChI=1S/C24H27FN8O3/c1-15(14-34)33-22(28-29-30-33)20-5-4-6-21(26-20)27-23(35)18-11-17-13-32(10-7-16(17)12-19(18)25)24(36)31-8-2-3-9-31/h4-6,11-12,15,34H,2-3,7-10,13-14H2,1H3,(H,26,27,35)/t15-/m1/s1
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Enanta Pharmaceuticals, Inc.

US Patent


Assay Description
HTRF KinEASE-STK is a generic method for measuring serine/threonine kinase activities using a time-resolved fluorescence resonance energy transfer (T...


US Patent US10450301 (2019)


BindingDB Entry DOI: 10.7270/Q2P84F7M
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM419031
PNG
(US10450301, Example 110)
Show SMILES CC(C)n1nnnc1-c1cccc(NC(=O)c2cc3CN(CCc3cn2)S(=O)(=O)C2CC2)n1
Show InChI InChI=1S/C21H24N8O3S/c1-13(2)29-20(25-26-27-29)17-4-3-5-19(23-17)24-21(30)18-10-15-12-28(9-8-14(15)11-22-18)33(31,32)16-6-7-16/h3-5,10-11,13,16H,6-9,12H2,1-2H3,(H,23,24,30)
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Enanta Pharmaceuticals, Inc.

US Patent


Assay Description
HTRF KinEASE-STK is a generic method for measuring serine/threonine kinase activities using a time-resolved fluorescence resonance energy transfer (T...


US Patent US10450301 (2019)


BindingDB Entry DOI: 10.7270/Q2P84F7M
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM419037
PNG
(US10450301, Example 116)
Show SMILES CC(C)n1nnnc1-c1cccc(NC(=O)c2cc3CN(CCc3cn2)C(=O)N(C)C)n1
Show InChI InChI=1S/C21H25N9O2/c1-13(2)30-19(25-26-27-30)16-6-5-7-18(23-16)24-20(31)17-10-15-12-29(21(32)28(3)4)9-8-14(15)11-22-17/h5-7,10-11,13H,8-9,12H2,1-4H3,(H,23,24,31)
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Enanta Pharmaceuticals, Inc.

US Patent


Assay Description
HTRF KinEASE-STK is a generic method for measuring serine/threonine kinase activities using a time-resolved fluorescence resonance energy transfer (T...


US Patent US10450301 (2019)


BindingDB Entry DOI: 10.7270/Q2P84F7M
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM419038
PNG
(US10450301, Example 117)
Show SMILES CCNC(=O)N1CCc2cnc(cc2C1)C(=O)Nc1cccc(n1)-c1nnnn1C(C)C
Show InChI InChI=1S/C21H25N9O2/c1-4-22-21(32)29-9-8-14-11-23-17(10-15(14)12-29)20(31)25-18-7-5-6-16(24-18)19-26-27-28-30(19)13(2)3/h5-7,10-11,13H,4,8-9,12H2,1-3H3,(H,22,32)(H,24,25,31)
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Enanta Pharmaceuticals, Inc.

US Patent


Assay Description
HTRF KinEASE-STK is a generic method for measuring serine/threonine kinase activities using a time-resolved fluorescence resonance energy transfer (T...


US Patent US10450301 (2019)


BindingDB Entry DOI: 10.7270/Q2P84F7M
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM419083
PNG
(US10450301, Example 162)
Show SMILES CC(C)OC(=O)N1CCc2cnc(cc2C1)C(=O)Nc1cccc(n1)-c1nnnn1[C@H](C)CO
Show InChI InChI=1S/C22H26N8O4/c1-13(2)34-22(33)29-8-7-15-10-23-18(9-16(15)11-29)21(32)25-19-6-4-5-17(24-19)20-26-27-28-30(20)14(3)12-31/h4-6,9-10,13-14,31H,7-8,11-12H2,1-3H3,(H,24,25,32)/t14-/m1/s1
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Enanta Pharmaceuticals, Inc.

US Patent


Assay Description
HTRF KinEASE-STK is a generic method for measuring serine/threonine kinase activities using a time-resolved fluorescence resonance energy transfer (T...


US Patent US10450301 (2019)


BindingDB Entry DOI: 10.7270/Q2P84F7M
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM419087
PNG
(US10450301, Example 166)
Show SMILES C[C@H](CO)n1nnnc1-c1cccc(NC(=O)c2cc3CN(CCc3cn2)S(=O)(=O)N(C)C)n1
Show InChI InChI=1S/C20H25N9O4S/c1-13(12-30)29-19(24-25-26-29)16-5-4-6-18(22-16)23-20(31)17-9-15-11-28(34(32,33)27(2)3)8-7-14(15)10-21-17/h4-6,9-10,13,30H,7-8,11-12H2,1-3H3,(H,22,23,31)/t13-/m1/s1
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Enanta Pharmaceuticals, Inc.

US Patent


Assay Description
HTRF KinEASE-STK is a generic method for measuring serine/threonine kinase activities using a time-resolved fluorescence resonance energy transfer (T...


US Patent US10450301 (2019)


BindingDB Entry DOI: 10.7270/Q2P84F7M
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM419092
PNG
(US10450301, Example 171)
Show SMILES C[C@H](CO)n1nnnc1-c1cccc(NC(=O)c2cc3CN(Cc4ccccn4)CCc3cn2)n1
Show InChI InChI=1S/C24H25N9O2/c1-16(15-34)33-23(29-30-31-33)20-6-4-7-22(27-20)28-24(35)21-11-18-13-32(10-8-17(18)12-26-21)14-19-5-2-3-9-25-19/h2-7,9,11-12,16,34H,8,10,13-15H2,1H3,(H,27,28,35)/t16-/m1/s1
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Enanta Pharmaceuticals, Inc.

US Patent


Assay Description
HTRF KinEASE-STK is a generic method for measuring serine/threonine kinase activities using a time-resolved fluorescence resonance energy transfer (T...


US Patent US10450301 (2019)


BindingDB Entry DOI: 10.7270/Q2P84F7M
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM418944
PNG
(US10450301, Example 23)
Show SMILES COCCS(=O)(=O)N1CCc2cc(F)c(cc2C1)C(=O)Nc1cccc(n1)-c1nncn1C(C)C
Show InChI InChI=1S/C23H27FN6O4S/c1-15(2)30-14-25-28-22(30)20-5-4-6-21(26-20)27-23(31)18-11-17-13-29(35(32,33)10-9-34-3)8-7-16(17)12-19(18)24/h4-6,11-12,14-15H,7-10,13H2,1-3H3,(H,26,27,31)
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Enanta Pharmaceuticals, Inc.

US Patent


Assay Description
HTRF KinEASE-STK is a generic method for measuring serine/threonine kinase activities using a time-resolved fluorescence resonance energy transfer (T...


US Patent US10450301 (2019)


BindingDB Entry DOI: 10.7270/Q2P84F7M
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM419041
PNG
(US10450301, Example 120)
Show SMILES C[C@H](CO)n1nnnc1-c1cccc(NC(=O)c2cc3CN(CCc3cn2)S(=O)(=O)c2ccccc2)n1
Show InChI InChI=1S/C24H24N8O4S/c1-16(15-33)32-23(28-29-30-32)20-8-5-9-22(26-20)27-24(34)21-12-18-14-31(11-10-17(18)13-25-21)37(35,36)19-6-3-2-4-7-19/h2-9,12-13,16,33H,10-11,14-15H2,1H3,(H,26,27,34)/t16-/m1/s1
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Enanta Pharmaceuticals, Inc.

US Patent


Assay Description
HTRF KinEASE-STK is a generic method for measuring serine/threonine kinase activities using a time-resolved fluorescence resonance energy transfer (T...


US Patent US10450301 (2019)


BindingDB Entry DOI: 10.7270/Q2P84F7M
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM419048
PNG
(US10450301, Example 127)
Show SMILES CC(C)COC(=O)N1CCc2cnc(cc2C1)C(=O)Nc1cccc(n1)-c1nnnn1[C@H](C)CO
Show InChI InChI=1S/C23H28N8O4/c1-14(2)13-35-23(34)30-8-7-16-10-24-19(9-17(16)11-30)22(33)26-20-6-4-5-18(25-20)21-27-28-29-31(21)15(3)12-32/h4-6,9-10,14-15,32H,7-8,11-13H2,1-3H3,(H,25,26,33)/t15-/m1/s1
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Enanta Pharmaceuticals, Inc.

US Patent


Assay Description
HTRF KinEASE-STK is a generic method for measuring serine/threonine kinase activities using a time-resolved fluorescence resonance energy transfer (T...


US Patent US10450301 (2019)


BindingDB Entry DOI: 10.7270/Q2P84F7M
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM419053
PNG
(US10450301, Example 132)
Show SMILES CC(C)NC(=O)N1CCc2cnc(cc2C1)C(=O)Nc1cccc(n1)-c1nnnn1[C@H](C)CO
Show InChI InChI=1S/C22H27N9O3/c1-13(2)24-22(34)30-8-7-15-10-23-18(9-16(15)11-30)21(33)26-19-6-4-5-17(25-19)20-27-28-29-31(20)14(3)12-32/h4-6,9-10,13-14,32H,7-8,11-12H2,1-3H3,(H,24,34)(H,25,26,33)/t14-/m1/s1
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Enanta Pharmaceuticals, Inc.

US Patent


Assay Description
HTRF KinEASE-STK is a generic method for measuring serine/threonine kinase activities using a time-resolved fluorescence resonance energy transfer (T...


US Patent US10450301 (2019)


BindingDB Entry DOI: 10.7270/Q2P84F7M
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM419054
PNG
(US10450301, Example 133)
Show SMILES C[C@H](CO)n1nnnc1-c1cccc(NC(=O)c2cc3CN(Cc4ccccc4)CCc3cn2)n1
Show InChI InChI=1S/C25H26N8O2/c1-17(16-34)33-24(29-30-31-33)21-8-5-9-23(27-21)28-25(35)22-12-20-15-32(11-10-19(20)13-26-22)14-18-6-3-2-4-7-18/h2-9,12-13,17,34H,10-11,14-16H2,1H3,(H,27,28,35)/t17-/m1/s1
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Enanta Pharmaceuticals, Inc.

US Patent


Assay Description
HTRF KinEASE-STK is a generic method for measuring serine/threonine kinase activities using a time-resolved fluorescence resonance energy transfer (T...


US Patent US10450301 (2019)


BindingDB Entry DOI: 10.7270/Q2P84F7M
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM419059
PNG
(US10450301, Example 138)
Show SMILES COCCS(=O)(=O)N1CCc2cnc(cc2C1)C(=O)Nc1cccc(n1)-c1nnnn1C(C)C
Show InChI InChI=1S/C21H26N8O4S/c1-14(2)29-20(25-26-27-29)17-5-4-6-19(23-17)24-21(30)18-11-16-13-28(8-7-15(16)12-22-18)34(31,32)10-9-33-3/h4-6,11-12,14H,7-10,13H2,1-3H3,(H,23,24,30)
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Enanta Pharmaceuticals, Inc.

US Patent


Assay Description
HTRF KinEASE-STK is a generic method for measuring serine/threonine kinase activities using a time-resolved fluorescence resonance energy transfer (T...


US Patent US10450301 (2019)


BindingDB Entry DOI: 10.7270/Q2P84F7M
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM419062
PNG
(US10450301, Example 141)
Show SMILES CC(C)CS(=O)(=O)N1CCc2cnc(cc2C1)C(=O)Nc1cccc(n1)-c1nnnn1C(C)C
Show InChI InChI=1S/C22H28N8O3S/c1-14(2)13-34(32,33)29-9-8-16-11-23-19(10-17(16)12-29)22(31)25-20-7-5-6-18(24-20)21-26-27-28-30(21)15(3)4/h5-7,10-11,14-15H,8-9,12-13H2,1-4H3,(H,24,25,31)
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Enanta Pharmaceuticals, Inc.

US Patent


Assay Description
HTRF KinEASE-STK is a generic method for measuring serine/threonine kinase activities using a time-resolved fluorescence resonance energy transfer (T...


US Patent US10450301 (2019)


BindingDB Entry DOI: 10.7270/Q2P84F7M
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM419089
PNG
(US10450301, Example 168)
Show SMILES C[C@H](CO)n1nnnc1-c1cccc(NC(=O)c2cc3CN(CCc3cn2)C(=O)N(C)C)n1
Show InChI InChI=1S/C21H25N9O3/c1-13(12-31)30-19(25-26-27-30)16-5-4-6-18(23-16)24-20(32)17-9-15-11-29(21(33)28(2)3)8-7-14(15)10-22-17/h4-6,9-10,13,31H,7-8,11-12H2,1-3H3,(H,23,24,32)/t13-/m1/s1
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Enanta Pharmaceuticals, Inc.

US Patent


Assay Description
HTRF KinEASE-STK is a generic method for measuring serine/threonine kinase activities using a time-resolved fluorescence resonance energy transfer (T...


US Patent US10450301 (2019)


BindingDB Entry DOI: 10.7270/Q2P84F7M
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM419102
PNG
(US10450301, Example 181)
Show SMILES C[C@H](CO)n1nnnc1-c1cccc(NC(=O)c2cc3CN(C)CCc3cn2)n1
Show InChI InChI=1S/C19H22N8O2/c1-12(11-28)27-18(23-24-25-27)15-4-3-5-17(21-15)22-19(29)16-8-14-10-26(2)7-6-13(14)9-20-16/h3-5,8-9,12,28H,6-7,10-11H2,1-2H3,(H,21,22,29)/t12-/m1/s1
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Enanta Pharmaceuticals, Inc.

US Patent


Assay Description
HTRF KinEASE-STK is a generic method for measuring serine/threonine kinase activities using a time-resolved fluorescence resonance energy transfer (T...


US Patent US10450301 (2019)


BindingDB Entry DOI: 10.7270/Q2P84F7M
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM418963
PNG
(US10450301, Example 42)
Show SMILES CC(C)CS(=O)(=O)N1CCc2cc(F)c(cc2C1)C(=O)Nc1cccc(n1)-c1nncn1C(C)C
Show InChI InChI=1S/C24H29FN6O3S/c1-15(2)13-35(33,34)30-9-8-17-11-20(25)19(10-18(17)12-30)24(32)28-22-7-5-6-21(27-22)23-29-26-14-31(23)16(3)4/h5-7,10-11,14-16H,8-9,12-13H2,1-4H3,(H,27,28,32)
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Enanta Pharmaceuticals, Inc.

US Patent


Assay Description
HTRF KinEASE-STK is a generic method for measuring serine/threonine kinase activities using a time-resolved fluorescence resonance energy transfer (T...


US Patent US10450301 (2019)


BindingDB Entry DOI: 10.7270/Q2P84F7M
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM418966
PNG
(US10450301, Example 45)
Show SMILES CCN(C)C(=O)N1CCc2cc(F)c(cc2C1)C(=O)Nc1cccc(n1)-c1nncn1C(C)C
Show InChI InChI=1S/C24H28FN7O2/c1-5-30(4)24(34)31-10-9-16-12-19(25)18(11-17(16)13-31)23(33)28-21-8-6-7-20(27-21)22-29-26-14-32(22)15(2)3/h6-8,11-12,14-15H,5,9-10,13H2,1-4H3,(H,27,28,33)
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Enanta Pharmaceuticals, Inc.

US Patent


Assay Description
HTRF KinEASE-STK is a generic method for measuring serine/threonine kinase activities using a time-resolved fluorescence resonance energy transfer (T...


US Patent US10450301 (2019)


BindingDB Entry DOI: 10.7270/Q2P84F7M
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM418967
PNG
(US10450301, Example 46)
Show SMILES CC(C)n1cnnc1-c1cccc(NC(=O)c2cc3CN(CCc3cc2F)S(=O)(=O)CCC(F)(F)F)n1
Show InChI InChI=1S/C23H24F4N6O3S/c1-14(2)33-13-28-31-21(33)19-4-3-5-20(29-19)30-22(34)17-10-16-12-32(8-6-15(16)11-18(17)24)37(35,36)9-7-23(25,26)27/h3-5,10-11,13-14H,6-9,12H2,1-2H3,(H,29,30,34)
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Enanta Pharmaceuticals, Inc.

US Patent


Assay Description
HTRF KinEASE-STK is a generic method for measuring serine/threonine kinase activities using a time-resolved fluorescence resonance energy transfer (T...


US Patent US10450301 (2019)


BindingDB Entry DOI: 10.7270/Q2P84F7M
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM418970
PNG
(US10450301, Example 49)
Show SMILES CC(C)n1cnnc1-c1cccc(NC(=O)c2cc3CN(CCc3cc2F)S(=O)(=O)N(C)C)n1
Show InChI InChI=1S/C22H26FN7O3S/c1-14(2)30-13-24-27-21(30)19-6-5-7-20(25-19)26-22(31)17-10-16-12-29(34(32,33)28(3)4)9-8-15(16)11-18(17)23/h5-7,10-11,13-14H,8-9,12H2,1-4H3,(H,25,26,31)
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Enanta Pharmaceuticals, Inc.

US Patent


Assay Description
HTRF KinEASE-STK is a generic method for measuring serine/threonine kinase activities using a time-resolved fluorescence resonance energy transfer (T...


US Patent US10450301 (2019)


BindingDB Entry DOI: 10.7270/Q2P84F7M
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM419042
PNG
(US10450301, Example 121)
Show SMILES C[C@H](CO)n1nnnc1-c1cccc(NC(=O)c2cc3CN(CCc3cn2)C(=O)c2ccc(F)cc2)n1
Show InChI InChI=1S/C25H23FN8O3/c1-15(14-35)34-23(30-31-32-34)20-3-2-4-22(28-20)29-24(36)21-11-18-13-33(10-9-17(18)12-27-21)25(37)16-5-7-19(26)8-6-16/h2-8,11-12,15,35H,9-10,13-14H2,1H3,(H,28,29,36)/t15-/m1/s1
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Enanta Pharmaceuticals, Inc.

US Patent


Assay Description
HTRF KinEASE-STK is a generic method for measuring serine/threonine kinase activities using a time-resolved fluorescence resonance energy transfer (T...


US Patent US10450301 (2019)


BindingDB Entry DOI: 10.7270/Q2P84F7M
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM419050
PNG
(US10450301, Example 129)
Show SMILES C[C@H](CO)n1nnnc1-c1cccc(NC(=O)c2cc3CN(CCc3cn2)C(=O)NCc2ccccc2)n1
Show InChI InChI=1S/C26H27N9O3/c1-17(16-36)35-24(31-32-33-35)21-8-5-9-23(29-21)30-25(37)22-12-20-15-34(11-10-19(20)14-27-22)26(38)28-13-18-6-3-2-4-7-18/h2-9,12,14,17,36H,10-11,13,15-16H2,1H3,(H,28,38)(H,29,30,37)/t17-/m1/s1
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Enanta Pharmaceuticals, Inc.

US Patent


Assay Description
HTRF KinEASE-STK is a generic method for measuring serine/threonine kinase activities using a time-resolved fluorescence resonance energy transfer (T...


US Patent US10450301 (2019)


BindingDB Entry DOI: 10.7270/Q2P84F7M
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM419055
PNG
(US10450301, Example 134)
Show SMILES COCCN1CCc2cnc(cc2C1)C(=O)Nc1cccc(n1)-c1nnnn1[C@H](C)CO
Show InChI InChI=1S/C21H26N8O3/c1-14(13-30)29-20(25-26-27-29)17-4-3-5-19(23-17)24-21(31)18-10-16-12-28(8-9-32-2)7-6-15(16)11-22-18/h3-5,10-11,14,30H,6-9,12-13H2,1-2H3,(H,23,24,31)/t14-/m1/s1
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Enanta Pharmaceuticals, Inc.

US Patent


Assay Description
HTRF KinEASE-STK is a generic method for measuring serine/threonine kinase activities using a time-resolved fluorescence resonance energy transfer (T...


US Patent US10450301 (2019)


BindingDB Entry DOI: 10.7270/Q2P84F7M
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM419076
PNG
(US10450301, Example 155)
Show SMILES C[C@H](CO)n1nnnc1-c1cccc(NC(=O)c2cc3CN(CCc3cn2)C(=O)C2CC2)n1
Show InChI InChI=1S/C22H24N8O3/c1-13(12-31)30-20(26-27-28-30)17-3-2-4-19(24-17)25-21(32)18-9-16-11-29(22(33)14-5-6-14)8-7-15(16)10-23-18/h2-4,9-10,13-14,31H,5-8,11-12H2,1H3,(H,24,25,32)/t13-/m1/s1
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Enanta Pharmaceuticals, Inc.

US Patent


Assay Description
HTRF KinEASE-STK is a generic method for measuring serine/threonine kinase activities using a time-resolved fluorescence resonance energy transfer (T...


US Patent US10450301 (2019)


BindingDB Entry DOI: 10.7270/Q2P84F7M
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM419078
PNG
(US10450301, Example 157)
Show SMILES C[C@H](CO)n1nnnc1-c1cccc(NC(=O)c2cc3CN(CCc3cn2)C(=O)OC2CCC2)n1
Show InChI InChI=1S/C23H26N8O4/c1-14(13-32)31-21(27-28-29-31)18-6-3-7-20(25-18)26-22(33)19-10-16-12-30(9-8-15(16)11-24-19)23(34)35-17-4-2-5-17/h3,6-7,10-11,14,17,32H,2,4-5,8-9,12-13H2,1H3,(H,25,26,33)/t14-/m1/s1
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Enanta Pharmaceuticals, Inc.

US Patent


Assay Description
HTRF KinEASE-STK is a generic method for measuring serine/threonine kinase activities using a time-resolved fluorescence resonance energy transfer (T...


US Patent US10450301 (2019)


BindingDB Entry DOI: 10.7270/Q2P84F7M
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM419081
PNG
(US10450301, Example 160)
Show SMILES CCCOC(=O)N1CCc2cnc(cc2C1)C(=O)Nc1cccc(n1)-c1nnnn1[C@H](C)CO
Show InChI InChI=1S/C22H26N8O4/c1-3-9-34-22(33)29-8-7-15-11-23-18(10-16(15)12-29)21(32)25-19-6-4-5-17(24-19)20-26-27-28-30(20)14(2)13-31/h4-6,10-11,14,31H,3,7-9,12-13H2,1-2H3,(H,24,25,32)/t14-/m1/s1
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Enanta Pharmaceuticals, Inc.

US Patent


Assay Description
HTRF KinEASE-STK is a generic method for measuring serine/threonine kinase activities using a time-resolved fluorescence resonance energy transfer (T...


US Patent US10450301 (2019)


BindingDB Entry DOI: 10.7270/Q2P84F7M
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM419085
PNG
(US10450301, Example 164)
Show SMILES CC(C)CN1CCc2cnc(cc2C1)C(=O)Nc1cccc(n1)-c1nnnn1[C@H](C)CO
Show InChI InChI=1S/C22H28N8O2/c1-14(2)11-29-8-7-16-10-23-19(9-17(16)12-29)22(32)25-20-6-4-5-18(24-20)21-26-27-28-30(21)15(3)13-31/h4-6,9-10,14-15,31H,7-8,11-13H2,1-3H3,(H,24,25,32)/t15-/m1/s1
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Enanta Pharmaceuticals, Inc.

US Patent


Assay Description
HTRF KinEASE-STK is a generic method for measuring serine/threonine kinase activities using a time-resolved fluorescence resonance energy transfer (T...


US Patent US10450301 (2019)


BindingDB Entry DOI: 10.7270/Q2P84F7M
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM419086
PNG
(US10450301, Example 165)
Show SMILES CCCN1CCc2cnc(cc2C1)C(=O)Nc1cccc(n1)-c1nnnn1[C@H](C)CO
Show InChI InChI=1S/C21H26N8O2/c1-3-8-28-9-7-15-11-22-18(10-16(15)12-28)21(31)24-19-6-4-5-17(23-19)20-25-26-27-29(20)14(2)13-30/h4-6,10-11,14,30H,3,7-9,12-13H2,1-2H3,(H,23,24,31)/t14-/m1/s1
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Enanta Pharmaceuticals, Inc.

US Patent


Assay Description
HTRF KinEASE-STK is a generic method for measuring serine/threonine kinase activities using a time-resolved fluorescence resonance energy transfer (T...


US Patent US10450301 (2019)


BindingDB Entry DOI: 10.7270/Q2P84F7M
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM419088
PNG
(US10450301, Example 167)
Show SMILES CCN(C)C(=O)N1CCc2cnc(cc2C1)C(=O)Nc1cccc(n1)-c1nnnn1[C@H](C)CO
Show InChI InChI=1S/C22H27N9O3/c1-4-29(3)22(34)30-9-8-15-11-23-18(10-16(15)12-30)21(33)25-19-7-5-6-17(24-19)20-26-27-28-31(20)14(2)13-32/h5-7,10-11,14,32H,4,8-9,12-13H2,1-3H3,(H,24,25,33)/t14-/m1/s1
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Enanta Pharmaceuticals, Inc.

US Patent


Assay Description
HTRF KinEASE-STK is a generic method for measuring serine/threonine kinase activities using a time-resolved fluorescence resonance energy transfer (T...


US Patent US10450301 (2019)


BindingDB Entry DOI: 10.7270/Q2P84F7M
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM419091
PNG
(US10450301, Example 170)
Show SMILES CCNC(=O)N1CCc2cnc(cc2C1)C(=O)Nc1cccc(n1)-c1nnnn1[C@H](C)CO
Show InChI InChI=1S/C21H25N9O3/c1-3-22-21(33)29-8-7-14-10-23-17(9-15(14)11-29)20(32)25-18-6-4-5-16(24-18)19-26-27-28-30(19)13(2)12-31/h4-6,9-10,13,31H,3,7-8,11-12H2,1-2H3,(H,22,33)(H,24,25,32)/t13-/m1/s1
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Enanta Pharmaceuticals, Inc.

US Patent


Assay Description
HTRF KinEASE-STK is a generic method for measuring serine/threonine kinase activities using a time-resolved fluorescence resonance energy transfer (T...


US Patent US10450301 (2019)


BindingDB Entry DOI: 10.7270/Q2P84F7M
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM419094
PNG
(US10450301, Example 173)
Show SMILES CC(C)n1nnnc1-c1cccc(NC(=O)c2cc3CN(CCc3cn2)C(=O)N2CCCC2)n1
Show InChI InChI=1S/C23H27N9O2/c1-15(2)32-21(27-28-29-32)18-6-5-7-20(25-18)26-22(33)19-12-17-14-31(11-8-16(17)13-24-19)23(34)30-9-3-4-10-30/h5-7,12-13,15H,3-4,8-11,14H2,1-2H3,(H,25,26,33)
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Enanta Pharmaceuticals, Inc.

US Patent


Assay Description
HTRF KinEASE-STK is a generic method for measuring serine/threonine kinase activities using a time-resolved fluorescence resonance energy transfer (T...


US Patent US10450301 (2019)


BindingDB Entry DOI: 10.7270/Q2P84F7M
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM419103
PNG
(US10450301, Example 182)
Show SMILES C[C@H](CO)n1nnnc1-c1cccc(NC(=O)c2cc3CN(CCc3cn2)C(=O)N2C3CCC2CCC3)n1
Show InChI InChI=1S/C26H31N9O3/c1-16(15-36)35-24(30-31-32-35)21-6-3-7-23(28-21)29-25(37)22-12-18-14-33(11-10-17(18)13-27-22)26(38)34-19-4-2-5-20(34)9-8-19/h3,6-7,12-13,16,19-20,36H,2,4-5,8-11,14-15H2,1H3,(H,28,29,37)/t16-,19?,20?/m1/s1
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Enanta Pharmaceuticals, Inc.

US Patent


Assay Description
HTRF KinEASE-STK is a generic method for measuring serine/threonine kinase activities using a time-resolved fluorescence resonance energy transfer (T...


US Patent US10450301 (2019)


BindingDB Entry DOI: 10.7270/Q2P84F7M
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM419106
PNG
(US10450301, Example 185)
Show SMILES C[C@H](CO)n1nnnc1-c1cccc(NC(=O)c2cc3CN(CCc3cn2)C(=O)N2CCC2)n1
Show InChI InChI=1S/C22H25N9O3/c1-14(13-32)31-20(26-27-28-31)17-4-2-5-19(24-17)25-21(33)18-10-16-12-30(9-6-15(16)11-23-18)22(34)29-7-3-8-29/h2,4-5,10-11,14,32H,3,6-9,12-13H2,1H3,(H,24,25,33)/t14-/m1/s1
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Enanta Pharmaceuticals, Inc.

US Patent


Assay Description
HTRF KinEASE-STK is a generic method for measuring serine/threonine kinase activities using a time-resolved fluorescence resonance energy transfer (T...


US Patent US10450301 (2019)


BindingDB Entry DOI: 10.7270/Q2P84F7M
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM419109
PNG
(US10450301, Example 188)
Show SMILES CCn1cc(COC(=O)N2CCc3cnc(cc3C2)C(=O)Nc2cccc(n2)-c2nnnn2[C@H](C)CO)cn1
Show InChI InChI=1S/C25H28N10O4/c1-3-34-12-17(10-27-34)15-39-25(38)33-8-7-18-11-26-21(9-19(18)13-33)24(37)29-22-6-4-5-20(28-22)23-30-31-32-35(23)16(2)14-36/h4-6,9-12,16,36H,3,7-8,13-15H2,1-2H3,(H,28,29,37)/t16-/m1/s1
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Enanta Pharmaceuticals, Inc.

US Patent


Assay Description
HTRF KinEASE-STK is a generic method for measuring serine/threonine kinase activities using a time-resolved fluorescence resonance energy transfer (T...


US Patent US10450301 (2019)


BindingDB Entry DOI: 10.7270/Q2P84F7M
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM418950
PNG
(US10450301, Example 29)
Show SMILES CCNC(=O)N1CCc2cc(F)c(cc2C1)C(=O)Nc1cccc(n1)-c1nnnn1C(C)C
Show InChI InChI=1S/C22H25FN8O2/c1-4-24-22(33)30-9-8-14-11-17(23)16(10-15(14)12-30)21(32)26-19-7-5-6-18(25-19)20-27-28-29-31(20)13(2)3/h5-7,10-11,13H,4,8-9,12H2,1-3H3,(H,24,33)(H,25,26,32)
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Enanta Pharmaceuticals, Inc.

US Patent


Assay Description
HTRF KinEASE-STK is a generic method for measuring serine/threonine kinase activities using a time-resolved fluorescence resonance energy transfer (T...


US Patent US10450301 (2019)


BindingDB Entry DOI: 10.7270/Q2P84F7M
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM418969
PNG
(US10450301, Example 48)
Show SMILES CC(C)n1cnnc1-c1cccc(NC(=O)c2cc3CN(CCc3cc2F)C(=O)N(C)C)n1
Show InChI InChI=1S/C23H26FN7O2/c1-14(2)31-13-25-28-21(31)19-6-5-7-20(26-19)27-22(32)17-10-16-12-30(23(33)29(3)4)9-8-15(16)11-18(17)24/h5-7,10-11,13-14H,8-9,12H2,1-4H3,(H,26,27,32)
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Enanta Pharmaceuticals, Inc.

US Patent


Assay Description
HTRF KinEASE-STK is a generic method for measuring serine/threonine kinase activities using a time-resolved fluorescence resonance energy transfer (T...


US Patent US10450301 (2019)


BindingDB Entry DOI: 10.7270/Q2P84F7M
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM419045
PNG
(US10450301, Example 124)
Show SMILES C[C@H](CO)n1nnnc1-c1cccc(NC(=O)c2cc3CN(CCc3cn2)C(=O)C2CCC2)n1
Show InChI InChI=1S/C23H26N8O3/c1-14(13-32)31-21(27-28-29-31)18-6-3-7-20(25-18)26-22(33)19-10-17-12-30(9-8-16(17)11-24-19)23(34)15-4-2-5-15/h3,6-7,10-11,14-15,32H,2,4-5,8-9,12-13H2,1H3,(H,25,26,33)/t14-/m1/s1
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Enanta Pharmaceuticals, Inc.

US Patent


Assay Description
HTRF KinEASE-STK is a generic method for measuring serine/threonine kinase activities using a time-resolved fluorescence resonance energy transfer (T...


US Patent US10450301 (2019)


BindingDB Entry DOI: 10.7270/Q2P84F7M
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM419051
PNG
(US10450301, Example 130)
Show SMILES COCCNC(=O)N1CCc2cnc(cc2C1)C(=O)Nc1cccc(n1)-c1nnnn1[C@H](C)CO
Show InChI InChI=1S/C22H27N9O4/c1-14(13-32)31-20(27-28-29-31)17-4-3-5-19(25-17)26-21(33)18-10-16-12-30(8-6-15(16)11-24-18)22(34)23-7-9-35-2/h3-5,10-11,14,32H,6-9,12-13H2,1-2H3,(H,23,34)(H,25,26,33)/t14-/m1/s1
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Enanta Pharmaceuticals, Inc.

US Patent


Assay Description
HTRF KinEASE-STK is a generic method for measuring serine/threonine kinase activities using a time-resolved fluorescence resonance energy transfer (T...


US Patent US10450301 (2019)


BindingDB Entry DOI: 10.7270/Q2P84F7M
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM419063
PNG
(US10450301, Example 142)
Show SMILES C[C@H](CO)n1nnnc1-c1cccc(NC(=O)c2cc3CN(CCc3cn2)C=O)n1
Show InChI InChI=1S/C19H20N8O3/c1-12(10-28)27-18(23-24-25-27)15-3-2-4-17(21-15)22-19(30)16-7-14-9-26(11-29)6-5-13(14)8-20-16/h2-4,7-8,11-12,28H,5-6,9-10H2,1H3,(H,21,22,30)/t12-/m1/s1
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Enanta Pharmaceuticals, Inc.

US Patent


Assay Description
HTRF KinEASE-STK is a generic method for measuring serine/threonine kinase activities using a time-resolved fluorescence resonance energy transfer (T...


US Patent US10450301 (2019)


BindingDB Entry DOI: 10.7270/Q2P84F7M
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM419064
PNG
(US10450301, Example 143)
Show SMILES C[C@H](CO)n1nnnc1-c1cccc(NC(=O)c2cc3CN(CCc3cn2)C(=O)OC(C)(C)C)n1
Show InChI InChI=1S/C23H28N8O4/c1-14(13-32)31-20(27-28-29-31)17-6-5-7-19(25-17)26-21(33)18-10-16-12-30(9-8-15(16)11-24-18)22(34)35-23(2,3)4/h5-7,10-11,14,32H,8-9,12-13H2,1-4H3,(H,25,26,33)/t14-/m1/s1
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Enanta Pharmaceuticals, Inc.

US Patent


Assay Description
HTRF KinEASE-STK is a generic method for measuring serine/threonine kinase activities using a time-resolved fluorescence resonance energy transfer (T...


US Patent US10450301 (2019)


BindingDB Entry DOI: 10.7270/Q2P84F7M
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM419080
PNG
(US10450301, Example 159)
Show SMILES C[C@H](CO)n1nnnc1-c1cccc(NC(=O)c2cc3CN(CCc3cn2)C(=O)OCC(C)(C)C)n1
Show InChI InChI=1S/C24H30N8O4/c1-15(13-33)32-21(28-29-30-32)18-6-5-7-20(26-18)27-22(34)19-10-17-12-31(9-8-16(17)11-25-19)23(35)36-14-24(2,3)4/h5-7,10-11,15,33H,8-9,12-14H2,1-4H3,(H,26,27,34)/t15-/m1/s1
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Enanta Pharmaceuticals, Inc.

US Patent


Assay Description
HTRF KinEASE-STK is a generic method for measuring serine/threonine kinase activities using a time-resolved fluorescence resonance energy transfer (T...


US Patent US10450301 (2019)


BindingDB Entry DOI: 10.7270/Q2P84F7M
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM419099
PNG
(US10450301, Example 178)
Show SMILES C[C@H](CO)n1nnnc1-c1cccc(NC(=O)c2cc3CN(Cc3cn2)C(=O)OCc2ccccc2)n1
Show InChI InChI=1S/C25H24N8O4/c1-16(14-34)33-23(29-30-31-33)20-8-5-9-22(27-20)28-24(35)21-10-18-12-32(13-19(18)11-26-21)25(36)37-15-17-6-3-2-4-7-17/h2-11,16,34H,12-15H2,1H3,(H,27,28,35)/t16-/m1/s1
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Enanta Pharmaceuticals, Inc.

US Patent


Assay Description
HTRF KinEASE-STK is a generic method for measuring serine/threonine kinase activities using a time-resolved fluorescence resonance energy transfer (T...


US Patent US10450301 (2019)


BindingDB Entry DOI: 10.7270/Q2P84F7M
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM419111
PNG
(US10450301, Example 190)
Show SMILES C[C@H](CO)n1nnnc1-c1cccc(NC(=O)c2cc3CN(CCc3cn2)C(=O)OC2CC3CCC(C2)N3C)n1
Show InChI InChI=1S/C27H33N9O4/c1-16(15-37)36-25(31-32-33-36)22-4-3-5-24(29-22)30-26(38)23-10-18-14-35(9-8-17(18)13-28-23)27(39)40-21-11-19-6-7-20(12-21)34(19)2/h3-5,10,13,16,19-21,37H,6-9,11-12,14-15H2,1-2H3,(H,29,30,38)/t16-,19?,20?,21?/m1/s1
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Enanta Pharmaceuticals, Inc.

US Patent


Assay Description
HTRF KinEASE-STK is a generic method for measuring serine/threonine kinase activities using a time-resolved fluorescence resonance energy transfer (T...


US Patent US10450301 (2019)


BindingDB Entry DOI: 10.7270/Q2P84F7M
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM418946
PNG
(US10450301, Example 25)
Show SMILES CC(C)n1cnnc1-c1cccc(NC(=O)c2cc3CN(CCc3cc2F)C(=O)OC2CCCC2)n1
Show InChI InChI=1S/C26H29FN6O3/c1-16(2)33-15-28-31-24(33)22-8-5-9-23(29-22)30-25(34)20-12-18-14-32(11-10-17(18)13-21(20)27)26(35)36-19-6-3-4-7-19/h5,8-9,12-13,15-16,19H,3-4,6-7,10-11,14H2,1-2H3,(H,29,30,34)
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Enanta Pharmaceuticals, Inc.

US Patent


Assay Description
HTRF KinEASE-STK is a generic method for measuring serine/threonine kinase activities using a time-resolved fluorescence resonance energy transfer (T...


US Patent US10450301 (2019)


BindingDB Entry DOI: 10.7270/Q2P84F7M
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM418968
PNG
(US10450301, Example 47)
Show SMILES CC(C)n1cnnc1-c1cccc(NC(=O)c2cc3CN(CCc3cc2F)S(=O)(=O)C2CC2)n1
Show InChI InChI=1S/C23H25FN6O3S/c1-14(2)30-13-25-28-22(30)20-4-3-5-21(26-20)27-23(31)18-10-16-12-29(34(32,33)17-6-7-17)9-8-15(16)11-19(18)24/h3-5,10-11,13-14,17H,6-9,12H2,1-2H3,(H,26,27,31)
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Enanta Pharmaceuticals, Inc.

US Patent


Assay Description
HTRF KinEASE-STK is a generic method for measuring serine/threonine kinase activities using a time-resolved fluorescence resonance energy transfer (T...


US Patent US10450301 (2019)


BindingDB Entry DOI: 10.7270/Q2P84F7M
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM418983
PNG
(US10450301, Example 62)
Show SMILES CCCCNC(=O)N1CCc2ccc(cc2C1)C(=O)Nc1cccc(n1)-c1nncn1C(C)C
Show InChI InChI=1S/C25H31N7O2/c1-4-5-12-26-25(34)31-13-11-18-9-10-19(14-20(18)15-31)24(33)29-22-8-6-7-21(28-22)23-30-27-16-32(23)17(2)3/h6-10,14,16-17H,4-5,11-13,15H2,1-3H3,(H,26,34)(H,28,29,33)
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Enanta Pharmaceuticals, Inc.

US Patent


Assay Description
HTRF KinEASE-STK is a generic method for measuring serine/threonine kinase activities using a time-resolved fluorescence resonance energy transfer (T...


US Patent US10450301 (2019)


BindingDB Entry DOI: 10.7270/Q2P84F7M
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM419015
PNG
(US10450301, Example 94)
Show SMILES CCN(CC)C(=O)N1CCc2cc(F)c(cc2C1)C(=O)Nc1cccc(n1)-c1nnnn1C(C)C
Show InChI InChI=1S/C24H29FN8O2/c1-5-31(6-2)24(35)32-11-10-16-13-19(25)18(12-17(16)14-32)23(34)27-21-9-7-8-20(26-21)22-28-29-30-33(22)15(3)4/h7-9,12-13,15H,5-6,10-11,14H2,1-4H3,(H,26,27,34)
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Enanta Pharmaceuticals, Inc.

US Patent


Assay Description
HTRF KinEASE-STK is a generic method for measuring serine/threonine kinase activities using a time-resolved fluorescence resonance energy transfer (T...


US Patent US10450301 (2019)


BindingDB Entry DOI: 10.7270/Q2P84F7M
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM419040
PNG
(US10450301, Example 119)
Show SMILES CC(C)n1nnnc1-c1cccc(NC(=O)c2cc3CN(CCc3cn2)C(=O)C2CCCC2)n1
Show InChI InChI=1S/C24H28N8O2/c1-15(2)32-22(28-29-30-32)19-8-5-9-21(26-19)27-23(33)20-12-18-14-31(11-10-17(18)13-25-20)24(34)16-6-3-4-7-16/h5,8-9,12-13,15-16H,3-4,6-7,10-11,14H2,1-2H3,(H,26,27,33)
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Enanta Pharmaceuticals, Inc.

US Patent


Assay Description
HTRF KinEASE-STK is a generic method for measuring serine/threonine kinase activities using a time-resolved fluorescence resonance energy transfer (T...


US Patent US10450301 (2019)


BindingDB Entry DOI: 10.7270/Q2P84F7M
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM419049
PNG
(US10450301, Example 128)
Show SMILES COC(=O)N1CCc2cnc(cc2C1)C(=O)Nc1cccc(n1)-c1nnnn1[C@H](C)CO
Show InChI InChI=1S/C20H22N8O4/c1-12(11-29)28-18(24-25-26-28)15-4-3-5-17(22-15)23-19(30)16-8-14-10-27(20(31)32-2)7-6-13(14)9-21-16/h3-5,8-9,12,29H,6-7,10-11H2,1-2H3,(H,22,23,30)/t12-/m1/s1
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Enanta Pharmaceuticals, Inc.

US Patent


Assay Description
HTRF KinEASE-STK is a generic method for measuring serine/threonine kinase activities using a time-resolved fluorescence resonance energy transfer (T...


US Patent US10450301 (2019)


BindingDB Entry DOI: 10.7270/Q2P84F7M
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM419060
PNG
(US10450301, Example 139)
Show SMILES CC(C)n1nnnc1-c1cccc(NC(=O)c2cc3CN(CCc3cn2)S(=O)(=O)CC2CC(F)(F)C2)n1
Show InChI InChI=1S/C23H26F2N8O3S/c1-14(2)33-21(29-30-31-33)18-4-3-5-20(27-18)28-22(34)19-8-17-12-32(7-6-16(17)11-26-19)37(35,36)13-15-9-23(24,25)10-15/h3-5,8,11,14-15H,6-7,9-10,12-13H2,1-2H3,(H,27,28,34)
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Enanta Pharmaceuticals, Inc.

US Patent


Assay Description
HTRF KinEASE-STK is a generic method for measuring serine/threonine kinase activities using a time-resolved fluorescence resonance energy transfer (T...


US Patent US10450301 (2019)


BindingDB Entry DOI: 10.7270/Q2P84F7M
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM419072
PNG
(US10450301, Example 151)
Show SMILES CC(C)CC(=O)N1CCc2cnc(cc2C1)C(=O)Nc1cccc(n1)-c1nnnn1[C@H](C)CO
Show InChI InChI=1S/C23H28N8O3/c1-14(2)9-21(33)30-8-7-16-11-24-19(10-17(16)12-30)23(34)26-20-6-4-5-18(25-20)22-27-28-29-31(22)15(3)13-32/h4-6,10-11,14-15,32H,7-9,12-13H2,1-3H3,(H,25,26,34)/t15-/m1/s1
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Enanta Pharmaceuticals, Inc.

US Patent


Assay Description
HTRF KinEASE-STK is a generic method for measuring serine/threonine kinase activities using a time-resolved fluorescence resonance energy transfer (T...


US Patent US10450301 (2019)


BindingDB Entry DOI: 10.7270/Q2P84F7M
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM419073
PNG
(US10450301, Example 152)
Show SMILES C[C@H](CO)n1nnnc1-c1cccc(NC(=O)c2cc3CN(CCc3cn2)C(=O)C(C)(C)C)n1
Show InChI InChI=1S/C23H28N8O3/c1-14(13-32)31-20(27-28-29-31)17-6-5-7-19(25-17)26-21(33)18-10-16-12-30(22(34)23(2,3)4)9-8-15(16)11-24-18/h5-7,10-11,14,32H,8-9,12-13H2,1-4H3,(H,25,26,33)/t14-/m1/s1
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Enanta Pharmaceuticals, Inc.

US Patent


Assay Description
HTRF KinEASE-STK is a generic method for measuring serine/threonine kinase activities using a time-resolved fluorescence resonance energy transfer (T...


US Patent US10450301 (2019)


BindingDB Entry DOI: 10.7270/Q2P84F7M
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM419084
PNG
(US10450301, Example 163)
Show SMILES C[C@H](CO)n1nnnc1-c1cccc(NC(=O)c2cc3CN(CC4CC4)CCc3cn2)n1
Show InChI InChI=1S/C22H26N8O2/c1-14(13-31)30-21(26-27-28-30)18-3-2-4-20(24-18)25-22(32)19-9-17-12-29(11-15-5-6-15)8-7-16(17)10-23-19/h2-4,9-10,14-15,31H,5-8,11-13H2,1H3,(H,24,25,32)/t14-/m1/s1
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Enanta Pharmaceuticals, Inc.

US Patent


Assay Description
HTRF KinEASE-STK is a generic method for measuring serine/threonine kinase activities using a time-resolved fluorescence resonance energy transfer (T...


US Patent US10450301 (2019)


BindingDB Entry DOI: 10.7270/Q2P84F7M
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM418942
PNG
(US10450301, Example 21)
Show SMILES CC(C)n1cnnc1-c1cccc(NC(=O)c2cc3CN(CCc3cc2F)S(=O)(=O)C2CCCC2)n1
Show InChI InChI=1S/C25H29FN6O3S/c1-16(2)32-15-27-30-24(32)22-8-5-9-23(28-22)29-25(33)20-12-18-14-31(11-10-17(18)13-21(20)26)36(34,35)19-6-3-4-7-19/h5,8-9,12-13,15-16,19H,3-4,6-7,10-11,14H2,1-2H3,(H,28,29,33)
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Enanta Pharmaceuticals, Inc.

US Patent


Assay Description
HTRF KinEASE-STK is a generic method for measuring serine/threonine kinase activities using a time-resolved fluorescence resonance energy transfer (T...


US Patent US10450301 (2019)


BindingDB Entry DOI: 10.7270/Q2P84F7M
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM418943
PNG
(US10450301, Example 22)
Show SMILES CCNS(=O)(=O)N1CCc2cc(F)c(cc2C1)C(=O)Nc1cccc(n1)-c1nncn1C(C)C
Show InChI InChI=1S/C22H26FN7O3S/c1-4-25-34(32,33)29-9-8-15-11-18(23)17(10-16(15)12-29)22(31)27-20-7-5-6-19(26-20)21-28-24-13-30(21)14(2)3/h5-7,10-11,13-14,25H,4,8-9,12H2,1-3H3,(H,26,27,31)
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Enanta Pharmaceuticals, Inc.

US Patent


Assay Description
HTRF KinEASE-STK is a generic method for measuring serine/threonine kinase activities using a time-resolved fluorescence resonance energy transfer (T...


US Patent US10450301 (2019)


BindingDB Entry DOI: 10.7270/Q2P84F7M
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM419096
PNG
(US10450301, Example 175)
Show SMILES COc1cc2CN(C(C)C)C(=O)c2cc1C(=O)Nc1cccc(n1)-c1nncn1C(C)C
Show InChI InChI=1S/C23H26N6O3/c1-13(2)28-11-15-9-19(32-5)17(10-16(15)23(28)31)22(30)26-20-8-6-7-18(25-20)21-27-24-12-29(21)14(3)4/h6-10,12-14H,11H2,1-5H3,(H,25,26,30)
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Enanta Pharmaceuticals, Inc.

US Patent


Assay Description
HTRF KinEASE-STK is a generic method for measuring serine/threonine kinase activities using a time-resolved fluorescence resonance energy transfer (T...


US Patent US10450301 (2019)


BindingDB Entry DOI: 10.7270/Q2P84F7M
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM418978
PNG
(US10450301, Example 57)
Show SMILES CC(C)n1nnnc1-c1cccc(NC(=O)c2cc3CN(CCc3cc2F)C(=O)OC2CCCC2)n1
Show InChI InChI=1S/C25H28FN7O3/c1-15(2)33-23(29-30-31-33)21-8-5-9-22(27-21)28-24(34)19-12-17-14-32(11-10-16(17)13-20(19)26)25(35)36-18-6-3-4-7-18/h5,8-9,12-13,15,18H,3-4,6-7,10-11,14H2,1-2H3,(H,27,28,34)
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Enanta Pharmaceuticals, Inc.

US Patent


Assay Description
HTRF KinEASE-STK is a generic method for measuring serine/threonine kinase activities using a time-resolved fluorescence resonance energy transfer (T...


US Patent US10450301 (2019)


BindingDB Entry DOI: 10.7270/Q2P84F7M
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM418980
PNG
(US10450301, Example 59)
Show SMILES CC(C)n1cnnc1-c1cccc(NC(=O)c2ccc3CCN(Cc3c2)C(=O)OCC=C)n1
Show InChI InChI=1S/C24H26N6O3/c1-4-12-33-24(32)29-11-10-17-8-9-18(13-19(17)14-29)23(31)27-21-7-5-6-20(26-21)22-28-25-15-30(22)16(2)3/h4-9,13,15-16H,1,10-12,14H2,2-3H3,(H,26,27,31)
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Enanta Pharmaceuticals, Inc.

US Patent


Assay Description
HTRF KinEASE-STK is a generic method for measuring serine/threonine kinase activities using a time-resolved fluorescence resonance energy transfer (T...


US Patent US10450301 (2019)


BindingDB Entry DOI: 10.7270/Q2P84F7M
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM418988
PNG
(US10450301, Example 67)
Show SMILES CC(C)n1cnnc1-c1cccc(NC(=O)c2ccc3CCN(Cc3c2)C(=O)OCc2ccccc2)n1
Show InChI InChI=1S/C28H28N6O3/c1-19(2)34-18-29-32-26(34)24-9-6-10-25(30-24)31-27(35)22-12-11-21-13-14-33(16-23(21)15-22)28(36)37-17-20-7-4-3-5-8-20/h3-12,15,18-19H,13-14,16-17H2,1-2H3,(H,30,31,35)
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Enanta Pharmaceuticals, Inc.

US Patent


Assay Description
HTRF KinEASE-STK is a generic method for measuring serine/threonine kinase activities using a time-resolved fluorescence resonance energy transfer (T...


US Patent US10450301 (2019)


BindingDB Entry DOI: 10.7270/Q2P84F7M
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM418991
PNG
(US10450301, Example 70)
Show SMILES CC(C)n1nnnc1-c1cccc(NC(=O)c2cc3C(C)N(CCc3cc2F)S(=O)(=O)CCC(F)(F)F)n1
Show InChI InChI=1S/C23H25F4N7O3S/c1-13(2)34-21(30-31-32-34)19-5-4-6-20(28-19)29-22(35)17-12-16-14(3)33(9-7-15(16)11-18(17)24)38(36,37)10-8-23(25,26)27/h4-6,11-14H,7-10H2,1-3H3,(H,28,29,35)
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Enanta Pharmaceuticals, Inc.

US Patent


Assay Description
HTRF KinEASE-STK is a generic method for measuring serine/threonine kinase activities using a time-resolved fluorescence resonance energy transfer (T...


US Patent US10450301 (2019)


BindingDB Entry DOI: 10.7270/Q2P84F7M
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM418998
PNG
(US10450301, Example 77)
Show SMILES CC(C)n1nnnc1-c1cccc(NC(=O)c2cc3CN(CCc3cc2F)C(=O)N(C)CC(F)(F)F)n1
Show InChI InChI=1S/C23H24F4N8O2/c1-13(2)35-20(30-31-32-35)18-5-4-6-19(28-18)29-21(36)16-9-15-11-34(8-7-14(15)10-17(16)24)22(37)33(3)12-23(25,26)27/h4-6,9-10,13H,7-8,11-12H2,1-3H3,(H,28,29,36)
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Enanta Pharmaceuticals, Inc.

US Patent


Assay Description
HTRF KinEASE-STK is a generic method for measuring serine/threonine kinase activities using a time-resolved fluorescence resonance energy transfer (T...


US Patent US10450301 (2019)


BindingDB Entry DOI: 10.7270/Q2P84F7M
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM419010
PNG
(US10450301, Example 89)
Show SMILES CC(C)n1nnnc1-c1cccc(NC(=O)c2cc3CN(CCc3cc2F)S(=O)(=O)N(C)C)n1
Show InChI InChI=1S/C21H25FN8O3S/c1-13(2)30-20(25-26-27-30)18-6-5-7-19(23-18)24-21(31)16-10-15-12-29(34(32,33)28(3)4)9-8-14(15)11-17(16)22/h5-7,10-11,13H,8-9,12H2,1-4H3,(H,23,24,31)
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Enanta Pharmaceuticals, Inc.

US Patent


Assay Description
HTRF KinEASE-STK is a generic method for measuring serine/threonine kinase activities using a time-resolved fluorescence resonance energy transfer (T...


US Patent US10450301 (2019)


BindingDB Entry DOI: 10.7270/Q2P84F7M
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM419016
PNG
(US10450301, Example 95)
Show SMILES CCN(C)C(=O)N1CCc2cc(F)c(cc2C1)C(=O)Nc1cccc(n1)-c1nnnn1C(C)C
Show InChI InChI=1S/C23H27FN8O2/c1-5-30(4)23(34)31-10-9-15-12-18(24)17(11-16(15)13-31)22(33)26-20-8-6-7-19(25-20)21-27-28-29-32(21)14(2)3/h6-8,11-12,14H,5,9-10,13H2,1-4H3,(H,25,26,33)
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Enanta Pharmaceuticals, Inc.

US Patent


Assay Description
HTRF KinEASE-STK is a generic method for measuring serine/threonine kinase activities using a time-resolved fluorescence resonance energy transfer (T...


US Patent US10450301 (2019)


BindingDB Entry DOI: 10.7270/Q2P84F7M
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM419017
PNG
(US10450301, Example 96)
Show SMILES CC(C)n1nnnc1-c1cccc(NC(=O)c2cc3CN(CCc3cc2F)C(=O)N(C)C)n1
Show InChI InChI=1S/C22H25FN8O2/c1-13(2)31-20(26-27-28-31)18-6-5-7-19(24-18)25-21(32)16-10-15-12-30(22(33)29(3)4)9-8-14(15)11-17(16)23/h5-7,10-11,13H,8-9,12H2,1-4H3,(H,24,25,32)
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Enanta Pharmaceuticals, Inc.

US Patent


Assay Description
HTRF KinEASE-STK is a generic method for measuring serine/threonine kinase activities using a time-resolved fluorescence resonance energy transfer (T...


US Patent US10450301 (2019)


BindingDB Entry DOI: 10.7270/Q2P84F7M
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM419035
PNG
(US10450301, Example 114)
Show SMILES CC(C)n1nnnc1-c1cccc(NC(=O)c2cc3CN(CCc3cn2)C(=O)N(C)CCC(F)(F)F)n1
Show InChI InChI=1S/C23H26F3N9O2/c1-14(2)35-20(30-31-32-35)17-5-4-6-19(28-17)29-21(36)18-11-16-13-34(9-7-15(16)12-27-18)22(37)33(3)10-8-23(24,25)26/h4-6,11-12,14H,7-10,13H2,1-3H3,(H,28,29,36)
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Enanta Pharmaceuticals, Inc.

US Patent


Assay Description
HTRF KinEASE-STK is a generic method for measuring serine/threonine kinase activities using a time-resolved fluorescence resonance energy transfer (T...


US Patent US10450301 (2019)


BindingDB Entry DOI: 10.7270/Q2P84F7M
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM419061
PNG
(US10450301, Example 140)
Show SMILES CC(C)n1nnnc1-c1cccc(NC(=O)c2cc3CN(CCc3cn2)S(=O)(=O)CC(F)(F)F)n1
Show InChI InChI=1S/C20H21F3N8O3S/c1-12(2)31-18(27-28-29-31)15-4-3-5-17(25-15)26-19(32)16-8-14-10-30(7-6-13(14)9-24-16)35(33,34)11-20(21,22)23/h3-5,8-9,12H,6-7,10-11H2,1-2H3,(H,25,26,32)
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Enanta Pharmaceuticals, Inc.

US Patent


Assay Description
HTRF KinEASE-STK is a generic method for measuring serine/threonine kinase activities using a time-resolved fluorescence resonance energy transfer (T...


US Patent US10450301 (2019)


BindingDB Entry DOI: 10.7270/Q2P84F7M
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM418939
PNG
(US10450301, Example 18)
Show SMILES CC(C)N1Cc2cnc(cc2C1=O)C(=O)Nc1cccc(n1)-c1nnnn1[C@H](C)CO
Show InChI InChI=1S/C20H22N8O3/c1-11(2)27-9-13-8-21-16(7-14(13)20(27)31)19(30)23-17-6-4-5-15(22-17)18-24-25-26-28(18)12(3)10-29/h4-8,11-12,29H,9-10H2,1-3H3,(H,22,23,30)/t12-/m1/s1
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Enanta Pharmaceuticals, Inc.

US Patent


Assay Description
HTRF KinEASE-STK is a generic method for measuring serine/threonine kinase activities using a time-resolved fluorescence resonance energy transfer (T...


US Patent US10450301 (2019)


BindingDB Entry DOI: 10.7270/Q2P84F7M
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM418952
PNG
(US10450301, Example 31)
Show SMILES CC(C)n1nnnc1-c1cccc(NC(=O)c2cc3CN(CCc3cc2F)C(=O)OCc2ccccc2)n1
Show InChI InChI=1S/C27H26FN7O3/c1-17(2)35-25(31-32-33-35)23-9-6-10-24(29-23)30-26(36)21-13-20-15-34(12-11-19(20)14-22(21)28)27(37)38-16-18-7-4-3-5-8-18/h3-10,13-14,17H,11-12,15-16H2,1-2H3,(H,29,30,36)
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Enanta Pharmaceuticals, Inc.

US Patent


Assay Description
HTRF KinEASE-STK is a generic method for measuring serine/threonine kinase activities using a time-resolved fluorescence resonance energy transfer (T...


US Patent US10450301 (2019)


BindingDB Entry DOI: 10.7270/Q2P84F7M
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM418955
PNG
(US10450301, Example 34)
Show SMILES CC(C)n1cnnc1-c1cccc(NC(=O)c2ccc3CCN(Cc3c2)C(=O)OC2CCCC2)n1
Show InChI InChI=1S/C26H30N6O3/c1-17(2)32-16-27-30-24(32)22-8-5-9-23(28-22)29-25(33)19-11-10-18-12-13-31(15-20(18)14-19)26(34)35-21-6-3-4-7-21/h5,8-11,14,16-17,21H,3-4,6-7,12-13,15H2,1-2H3,(H,28,29,33)
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Enanta Pharmaceuticals, Inc.

US Patent


Assay Description
HTRF KinEASE-STK is a generic method for measuring serine/threonine kinase activities using a time-resolved fluorescence resonance energy transfer (T...


US Patent US10450301 (2019)


BindingDB Entry DOI: 10.7270/Q2P84F7M
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM418971
PNG
(US10450301, Example 50)
Show SMILES CC(C)n1cnnc1-c1cccc(NC(=O)c2cc3CN(CCc3cc2F)C(=O)N2CCOCC2)n1
Show InChI InChI=1S/C25H28FN7O3/c1-16(2)33-15-27-30-23(33)21-4-3-5-22(28-21)29-24(34)19-12-18-14-32(7-6-17(18)13-20(19)26)25(35)31-8-10-36-11-9-31/h3-5,12-13,15-16H,6-11,14H2,1-2H3,(H,28,29,34)
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Enanta Pharmaceuticals, Inc.

US Patent


Assay Description
HTRF KinEASE-STK is a generic method for measuring serine/threonine kinase activities using a time-resolved fluorescence resonance energy transfer (T...


US Patent US10450301 (2019)


BindingDB Entry DOI: 10.7270/Q2P84F7M
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM419000
PNG
(US10450301, Example 79)
Show SMILES CC(C)CN(C)C(=O)N1CCc2cc(F)c(cc2C1)C(=O)Nc1cccc(n1)-c1nnnn1C(C)C
Show InChI InChI=1S/C25H31FN8O2/c1-15(2)13-32(5)25(36)33-10-9-17-12-20(26)19(11-18(17)14-33)24(35)28-22-8-6-7-21(27-22)23-29-30-31-34(23)16(3)4/h6-8,11-12,15-16H,9-10,13-14H2,1-5H3,(H,27,28,35)
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Enanta Pharmaceuticals, Inc.

US Patent


Assay Description
HTRF KinEASE-STK is a generic method for measuring serine/threonine kinase activities using a time-resolved fluorescence resonance energy transfer (T...


US Patent US10450301 (2019)


BindingDB Entry DOI: 10.7270/Q2P84F7M
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM419006
PNG
(US10450301, Example 85)
Show SMILES CC(C)n1nnnc1-c1cccc(NC(=O)c2cc3CN(CCc3cc2F)S(=O)(=O)C2CCCC2)n1
Show InChI InChI=1S/C24H28FN7O3S/c1-15(2)32-23(28-29-30-32)21-8-5-9-22(26-21)27-24(33)19-12-17-14-31(11-10-16(17)13-20(19)25)36(34,35)18-6-3-4-7-18/h5,8-9,12-13,15,18H,3-4,6-7,10-11,14H2,1-2H3,(H,26,27,33)
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Enanta Pharmaceuticals, Inc.

US Patent


Assay Description
HTRF KinEASE-STK is a generic method for measuring serine/threonine kinase activities using a time-resolved fluorescence resonance energy transfer (T...


US Patent US10450301 (2019)


BindingDB Entry DOI: 10.7270/Q2P84F7M
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM419011
PNG
(US10450301, Example 90)
Show SMILES CCN1CCN(C(=O)N2CCc3cc(F)c(cc3C2)C(=O)Nc2cccc(n2)-c2nnnn2C(C)C)C(=O)C1=O
Show InChI InChI=1S/C26H28FN9O4/c1-4-33-10-11-35(25(39)24(33)38)26(40)34-9-8-16-13-19(27)18(12-17(16)14-34)23(37)29-21-7-5-6-20(28-21)22-30-31-32-36(22)15(2)3/h5-7,12-13,15H,4,8-11,14H2,1-3H3,(H,28,29,37)
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Enanta Pharmaceuticals, Inc.

US Patent


Assay Description
HTRF KinEASE-STK is a generic method for measuring serine/threonine kinase activities using a time-resolved fluorescence resonance energy transfer (T...


US Patent US10450301 (2019)


BindingDB Entry DOI: 10.7270/Q2P84F7M
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM419014
PNG
(US10450301, Example 93)
Show SMILES CC(C)n1nnnc1-c1cccc(NC(=O)c2cc3CN(CCc3cc2F)C(=O)N2CCCC2)n1
Show InChI InChI=1S/C24H27FN8O2/c1-15(2)33-22(28-29-30-33)20-6-5-7-21(26-20)27-23(34)18-12-17-14-32(11-8-16(17)13-19(18)25)24(35)31-9-3-4-10-31/h5-7,12-13,15H,3-4,8-11,14H2,1-2H3,(H,26,27,34)
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Enanta Pharmaceuticals, Inc.

US Patent


Assay Description
HTRF KinEASE-STK is a generic method for measuring serine/threonine kinase activities using a time-resolved fluorescence resonance energy transfer (T...


US Patent US10450301 (2019)


BindingDB Entry DOI: 10.7270/Q2P84F7M
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM419024
PNG
(US10450301, Example 103 | US10450301, Example 104)
Show SMILES CC(C)n1nnnc1-c1cccc(NC(=O)c2cc3CN(CCc3cc2F)C(=O)N2CCS(=O)(=O)CC2)n1
Show InChI InChI=1S/C24H27FN8O4S/c1-15(2)33-22(28-29-30-33)20-4-3-5-21(26-20)27-23(34)18-12-17-14-32(7-6-16(17)13-19(18)25)24(35)31-8-10-38(36,37)11-9-31/h3-5,12-13,15H,6-11,14H2,1-2H3,(H,26,27,34)
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Enanta Pharmaceuticals, Inc.

US Patent


Assay Description
HTRF KinEASE-STK is a generic method for measuring serine/threonine kinase activities using a time-resolved fluorescence resonance energy transfer (T...


US Patent US10450301 (2019)


BindingDB Entry DOI: 10.7270/Q2P84F7M
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM419028
PNG
(US10450301, Example 107)
Show SMILES CC(C)n1nnnc1-c1cccc(NC(=O)c2cc3CN(CCc3cc2F)C(=O)N(C)CCC(F)(F)F)n1
Show InChI InChI=1S/C24H26F4N8O2/c1-14(2)36-21(31-32-33-36)19-5-4-6-20(29-19)30-22(37)17-11-16-13-35(9-7-15(16)12-18(17)25)23(38)34(3)10-8-24(26,27)28/h4-6,11-12,14H,7-10,13H2,1-3H3,(H,29,30,37)
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Enanta Pharmaceuticals, Inc.

US Patent


Assay Description
HTRF KinEASE-STK is a generic method for measuring serine/threonine kinase activities using a time-resolved fluorescence resonance energy transfer (T...


US Patent US10450301 (2019)


BindingDB Entry DOI: 10.7270/Q2P84F7M
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM419056
PNG
(US10450301, Example 135)
Show SMILES CC(C)N1CCc2cnc(cc2C1)C(=O)Nc1cccc(n1)-c1nnnn1[C@H](C)CO
Show InChI InChI=1S/C21H26N8O2/c1-13(2)28-8-7-15-10-22-18(9-16(15)11-28)21(31)24-19-6-4-5-17(23-19)20-25-26-27-29(20)14(3)12-30/h4-6,9-10,13-14,30H,7-8,11-12H2,1-3H3,(H,23,24,31)/t14-/m1/s1
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Enanta Pharmaceuticals, Inc.

US Patent


Assay Description
HTRF KinEASE-STK is a generic method for measuring serine/threonine kinase activities using a time-resolved fluorescence resonance energy transfer (T...


US Patent US10450301 (2019)


BindingDB Entry DOI: 10.7270/Q2P84F7M
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM419107
PNG
(US10450301, Example 186)
Show SMILES C[C@H](CO)n1nnnc1-c1cccc(NC(=O)c2cc3CN(CCc3cn2)C(=O)NC2COC2)n1
Show InChI InChI=1S/C22H25N9O4/c1-13(10-32)31-20(27-28-29-31)17-3-2-4-19(25-17)26-21(33)18-7-15-9-30(6-5-14(15)8-23-18)22(34)24-16-11-35-12-16/h2-4,7-8,13,16,32H,5-6,9-12H2,1H3,(H,24,34)(H,25,26,33)/t13-/m1/s1
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Enanta Pharmaceuticals, Inc.

US Patent


Assay Description
HTRF KinEASE-STK is a generic method for measuring serine/threonine kinase activities using a time-resolved fluorescence resonance energy transfer (T...


US Patent US10450301 (2019)


BindingDB Entry DOI: 10.7270/Q2P84F7M
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM418953
PNG
(US10450301, Example 32)
Show SMILES CC(C)n1cnnc1-c1cccc(NC(=O)c2ccc3CCN(Cc3c2)C(=O)c2nccs2)n1
Show InChI InChI=1S/C24H23N7O2S/c1-15(2)31-14-26-29-21(31)19-4-3-5-20(27-19)28-22(32)17-7-6-16-8-10-30(13-18(16)12-17)24(33)23-25-9-11-34-23/h3-7,9,11-12,14-15H,8,10,13H2,1-2H3,(H,27,28,32)
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Enanta Pharmaceuticals, Inc.

US Patent


Assay Description
HTRF KinEASE-STK is a generic method for measuring serine/threonine kinase activities using a time-resolved fluorescence resonance energy transfer (T...


US Patent US10450301 (2019)


BindingDB Entry DOI: 10.7270/Q2P84F7M
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM418964
PNG
(US10450301, Example 43)
Show SMILES CC(C)n1cnnc1-c1cccc(NC(=O)c2cc3CN(CCc3cc2F)S(=O)(=O)CC2CC2)n1
Show InChI InChI=1S/C24H27FN6O3S/c1-15(2)31-14-26-29-23(31)21-4-3-5-22(27-21)28-24(32)19-10-18-12-30(9-8-17(18)11-20(19)25)35(33,34)13-16-6-7-16/h3-5,10-11,14-16H,6-9,12-13H2,1-2H3,(H,27,28,32)
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Enanta Pharmaceuticals, Inc.

US Patent


Assay Description
HTRF KinEASE-STK is a generic method for measuring serine/threonine kinase activities using a time-resolved fluorescence resonance energy transfer (T...


US Patent US10450301 (2019)


BindingDB Entry DOI: 10.7270/Q2P84F7M
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM418974
PNG
(US10450301, Example 53)
Show SMILES CC(C)n1cnnc1-c1cccc(NC(=O)c2cc3CN(CCc3cc2F)C(=O)OCc2ccccc2)n1
Show InChI InChI=1S/C28H27FN6O3/c1-18(2)35-17-30-33-26(35)24-9-6-10-25(31-24)32-27(36)22-13-21-15-34(12-11-20(21)14-23(22)29)28(37)38-16-19-7-4-3-5-8-19/h3-10,13-14,17-18H,11-12,15-16H2,1-2H3,(H,31,32,36)
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Enanta Pharmaceuticals, Inc.

US Patent


Assay Description
HTRF KinEASE-STK is a generic method for measuring serine/threonine kinase activities using a time-resolved fluorescence resonance energy transfer (T...


US Patent US10450301 (2019)


BindingDB Entry DOI: 10.7270/Q2P84F7M
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM418987
PNG
(US10450301, Example 66)
Show SMILES CC(C)COC(=O)N1CCc2ccc(cc2C1)C(=O)Nc1cccc(n1)-c1nncn1C(C)C
Show InChI InChI=1S/C25H30N6O3/c1-16(2)14-34-25(33)30-11-10-18-8-9-19(12-20(18)13-30)24(32)28-22-7-5-6-21(27-22)23-29-26-15-31(23)17(3)4/h5-9,12,15-17H,10-11,13-14H2,1-4H3,(H,27,28,32)
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Enanta Pharmaceuticals, Inc.

US Patent


Assay Description
HTRF KinEASE-STK is a generic method for measuring serine/threonine kinase activities using a time-resolved fluorescence resonance energy transfer (T...


US Patent US10450301 (2019)


BindingDB Entry DOI: 10.7270/Q2P84F7M
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM419074
PNG
(US10450301, Example 153)
Show SMILES CC(C)n1nnnc1-c1cccc(NC(=O)c2cc3CN(CCc3cn2)C(=O)OC(C)(C)C)n1
Show InChI InChI=1S/C23H28N8O3/c1-14(2)31-20(27-28-29-31)17-7-6-8-19(25-17)26-21(32)18-11-16-13-30(10-9-15(16)12-24-18)22(33)34-23(3,4)5/h6-8,11-12,14H,9-10,13H2,1-5H3,(H,25,26,32)
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Enanta Pharmaceuticals, Inc.

US Patent


Assay Description
HTRF KinEASE-STK is a generic method for measuring serine/threonine kinase activities using a time-resolved fluorescence resonance energy transfer (T...


US Patent US10450301 (2019)


BindingDB Entry DOI: 10.7270/Q2P84F7M
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM419110
PNG
(US10450301, Example 189)
Show SMILES CCOC(=O)N1Cc2cnc(cc2C1)C(=O)Nc1cccc(n1)-c1nncn1C(C)C
Show InChI InChI=1S/C21H23N7O3/c1-4-31-21(30)27-10-14-8-17(22-9-15(14)11-27)20(29)25-18-7-5-6-16(24-18)19-26-23-12-28(19)13(2)3/h5-9,12-13H,4,10-11H2,1-3H3,(H,24,25,29)
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Enanta Pharmaceuticals, Inc.

US Patent


Assay Description
HTRF KinEASE-STK is a generic method for measuring serine/threonine kinase activities using a time-resolved fluorescence resonance energy transfer (T...


US Patent US10450301 (2019)


BindingDB Entry DOI: 10.7270/Q2P84F7M
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM418924
PNG
(US10450301, Example 3)
Show SMILES CC(C)n1cnnc1-c1cccc(NC(=O)c2ccc3CN(Cc3c2)C(=O)OCc2ccccc2)n1
Show InChI InChI=1S/C27H26N6O3/c1-18(2)33-17-28-31-25(33)23-9-6-10-24(29-23)30-26(34)20-11-12-21-14-32(15-22(21)13-20)27(35)36-16-19-7-4-3-5-8-19/h3-13,17-18H,14-16H2,1-2H3,(H,29,30,34)
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Enanta Pharmaceuticals, Inc.

US Patent


Assay Description
HTRF KinEASE-STK is a generic method for measuring serine/threonine kinase activities using a time-resolved fluorescence resonance energy transfer (T...


US Patent US10450301 (2019)


BindingDB Entry DOI: 10.7270/Q2P84F7M
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM418951
PNG
(US10450301, Example 30)
Show SMILES CCOC(=O)N1CCc2cc(F)c(cc2C1)C(=O)Nc1cccc(n1)-c1nnnn1C(C)C
Show InChI InChI=1S/C22H24FN7O3/c1-4-33-22(32)29-9-8-14-11-17(23)16(10-15(14)12-29)21(31)25-19-7-5-6-18(24-19)20-26-27-28-30(20)13(2)3/h5-7,10-11,13H,4,8-9,12H2,1-3H3,(H,24,25,31)
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Enanta Pharmaceuticals, Inc.

US Patent


Assay Description
HTRF KinEASE-STK is a generic method for measuring serine/threonine kinase activities using a time-resolved fluorescence resonance energy transfer (T...


US Patent US10450301 (2019)


BindingDB Entry DOI: 10.7270/Q2P84F7M
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM418981
PNG
(US10450301, Example 60)
Show SMILES COCCC(=O)N1CCc2ccc(cc2C1)C(=O)Nc1cccc(n1)-c1nncn1C(C)C
Show InChI InChI=1S/C24H28N6O3/c1-16(2)30-15-25-28-23(30)20-5-4-6-21(26-20)27-24(32)18-8-7-17-9-11-29(14-19(17)13-18)22(31)10-12-33-3/h4-8,13,15-16H,9-12,14H2,1-3H3,(H,26,27,32)
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Enanta Pharmaceuticals, Inc.

US Patent


Assay Description
HTRF KinEASE-STK is a generic method for measuring serine/threonine kinase activities using a time-resolved fluorescence resonance energy transfer (T...


US Patent US10450301 (2019)


BindingDB Entry DOI: 10.7270/Q2P84F7M
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM419026
PNG
(US10450301, Example 105)
Show SMILES CC(C)n1nnnc1-c1cccc(NC(=O)c2cc3CN(CCc3cc2F)C(=O)N2CCSCC2)n1
Show InChI InChI=1S/C24H27FN8O2S/c1-15(2)33-22(28-29-30-33)20-4-3-5-21(26-20)27-23(34)18-12-17-14-32(7-6-16(17)13-19(18)25)24(35)31-8-10-36-11-9-31/h3-5,12-13,15H,6-11,14H2,1-2H3,(H,26,27,34)
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Enanta Pharmaceuticals, Inc.

US Patent


Assay Description
HTRF KinEASE-STK is a generic method for measuring serine/threonine kinase activities using a time-resolved fluorescence resonance energy transfer (T...


US Patent US10450301 (2019)


BindingDB Entry DOI: 10.7270/Q2P84F7M
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM419033
PNG
(US10450301, Example 112)
Show SMILES CC(C)n1nnnc1-c1cccc(NC(=O)c2cc3CN(CCc3cn2)C(=O)N(C)C2CCCC2)n1
Show InChI InChI=1S/C25H31N9O2/c1-16(2)34-23(29-30-31-34)20-9-6-10-22(27-20)28-24(35)21-13-18-15-33(12-11-17(18)14-26-21)25(36)32(3)19-7-4-5-8-19/h6,9-10,13-14,16,19H,4-5,7-8,11-12,15H2,1-3H3,(H,27,28,35)
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Enanta Pharmaceuticals, Inc.

US Patent


Assay Description
HTRF KinEASE-STK is a generic method for measuring serine/threonine kinase activities using a time-resolved fluorescence resonance energy transfer (T...


US Patent US10450301 (2019)


BindingDB Entry DOI: 10.7270/Q2P84F7M
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM419057
PNG
(US10450301, Example 136)
Show SMILES CCN1CCc2cnc(cc2C1)C(=O)Nc1cccc(n1)-c1nnnn1[C@H](C)CO
Show InChI InChI=1S/C20H24N8O2/c1-3-27-8-7-14-10-21-17(9-15(14)11-27)20(30)23-18-6-4-5-16(22-18)19-24-25-26-28(19)13(2)12-29/h4-6,9-10,13,29H,3,7-8,11-12H2,1-2H3,(H,22,23,30)/t13-/m1/s1
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Enanta Pharmaceuticals, Inc.

US Patent


Assay Description
HTRF KinEASE-STK is a generic method for measuring serine/threonine kinase activities using a time-resolved fluorescence resonance energy transfer (T...


US Patent US10450301 (2019)


BindingDB Entry DOI: 10.7270/Q2P84F7M
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM418949
PNG
(US10450301, Example 28)
Show SMILES COCCC(=O)N1CCc2cc(F)c(cc2C1)C(=O)Nc1cccc(n1)-c1nnnn1C(C)C
Show InChI InChI=1S/C23H26FN7O3/c1-14(2)31-22(27-28-29-31)19-5-4-6-20(25-19)26-23(33)17-11-16-13-30(21(32)8-10-34-3)9-7-15(16)12-18(17)24/h4-6,11-12,14H,7-10,13H2,1-3H3,(H,25,26,33)
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Enanta Pharmaceuticals, Inc.

US Patent


Assay Description
HTRF KinEASE-STK is a generic method for measuring serine/threonine kinase activities using a time-resolved fluorescence resonance energy transfer (T...


US Patent US10450301 (2019)


BindingDB Entry DOI: 10.7270/Q2P84F7M
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM418954
PNG
(US10450301, Example 33)
Show SMILES CC(C)n1cnnc1-c1cccc(NC(=O)c2ccc3CCN(Cc3c2)C(=O)NCC=C)n1
Show InChI InChI=1S/C24H27N7O2/c1-4-11-25-24(33)30-12-10-17-8-9-18(13-19(17)14-30)23(32)28-21-7-5-6-20(27-21)22-29-26-15-31(22)16(2)3/h4-9,13,15-16H,1,10-12,14H2,2-3H3,(H,25,33)(H,27,28,32)
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Enanta Pharmaceuticals, Inc.

US Patent


Assay Description
HTRF KinEASE-STK is a generic method for measuring serine/threonine kinase activities using a time-resolved fluorescence resonance energy transfer (T...


US Patent US10450301 (2019)


BindingDB Entry DOI: 10.7270/Q2P84F7M
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM418957
PNG
(US10450301, Example 36)
Show SMILES CCOC(=O)N1CCc2ccc(cc2C1)C(=O)Nc1cccc(n1)-c1nncn1C(C)C
Show InChI InChI=1S/C23H26N6O3/c1-4-32-23(31)28-11-10-16-8-9-17(12-18(16)13-28)22(30)26-20-7-5-6-19(25-20)21-27-24-14-29(21)15(2)3/h5-9,12,14-15H,4,10-11,13H2,1-3H3,(H,25,26,30)
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Enanta Pharmaceuticals, Inc.

US Patent


Assay Description
HTRF KinEASE-STK is a generic method for measuring serine/threonine kinase activities using a time-resolved fluorescence resonance energy transfer (T...


US Patent US10450301 (2019)


BindingDB Entry DOI: 10.7270/Q2P84F7M
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM418975
PNG
(US10450301, Example 54)
Show SMILES CC(C)n1nnnc1-c1cccc(NC(=O)c2cc3CN(CCc3cc2F)c2ccccc2)n1
Show InChI InChI=1S/C25H24FN7O/c1-16(2)33-24(29-30-31-33)22-9-6-10-23(27-22)28-25(34)20-13-18-15-32(19-7-4-3-5-8-19)12-11-17(18)14-21(20)26/h3-10,13-14,16H,11-12,15H2,1-2H3,(H,27,28,34)
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Enanta Pharmaceuticals, Inc.

US Patent


Assay Description
HTRF KinEASE-STK is a generic method for measuring serine/threonine kinase activities using a time-resolved fluorescence resonance energy transfer (T...


US Patent US10450301 (2019)


BindingDB Entry DOI: 10.7270/Q2P84F7M
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM418996
PNG
(US10450301, Example 75)
Show SMILES C[C@H](CO)n1nnnc1-c1cccc(NC(=O)c2cc3CN(CCc3cc2F)C(=O)N(C)CC(F)(F)F)n1
Show InChI InChI=1S/C23H24F4N8O3/c1-13(11-36)35-20(30-31-32-35)18-4-3-5-19(28-18)29-21(37)16-8-15-10-34(7-6-14(15)9-17(16)24)22(38)33(2)12-23(25,26)27/h3-5,8-9,13,36H,6-7,10-12H2,1-2H3,(H,28,29,37)/t13-/m1/s1
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Enanta Pharmaceuticals, Inc.

US Patent


Assay Description
HTRF KinEASE-STK is a generic method for measuring serine/threonine kinase activities using a time-resolved fluorescence resonance energy transfer (T...


US Patent US10450301 (2019)


BindingDB Entry DOI: 10.7270/Q2P84F7M
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM419001
PNG
(US10450301, Example 80)
Show SMILES CC(C)N(C)C(=O)N1CCc2cc(F)c(cc2C1)C(=O)Nc1cccc(n1)-c1nnnn1C(C)C
Show InChI InChI=1S/C24H29FN8O2/c1-14(2)31(5)24(35)32-10-9-16-12-19(25)18(11-17(16)13-32)23(34)27-21-8-6-7-20(26-21)22-28-29-30-33(22)15(3)4/h6-8,11-12,14-15H,9-10,13H2,1-5H3,(H,26,27,34)
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Enanta Pharmaceuticals, Inc.

US Patent


Assay Description
HTRF KinEASE-STK is a generic method for measuring serine/threonine kinase activities using a time-resolved fluorescence resonance energy transfer (T...


US Patent US10450301 (2019)


BindingDB Entry DOI: 10.7270/Q2P84F7M
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM419018
PNG
(US10450301, Example 97)
Show SMILES CC(C)n1nnnc1-c1cccc(NC(=O)c2cc3CN(CCc3cc2F)C(=O)C2CCCC2)n1
Show InChI InChI=1S/C25H28FN7O2/c1-15(2)33-23(29-30-31-33)21-8-5-9-22(27-21)28-24(34)19-12-18-14-32(11-10-17(18)13-20(19)26)25(35)16-6-3-4-7-16/h5,8-9,12-13,15-16H,3-4,6-7,10-11,14H2,1-2H3,(H,27,28,34)
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Enanta Pharmaceuticals, Inc.

US Patent


Assay Description
HTRF KinEASE-STK is a generic method for measuring serine/threonine kinase activities using a time-resolved fluorescence resonance energy transfer (T...


US Patent US10450301 (2019)


BindingDB Entry DOI: 10.7270/Q2P84F7M
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM419023
PNG
(US10450301, Example 102)
Show SMILES CC(C)n1nnnc1-c1cccc(NC(=O)c2cc3CN(CCc3cc2F)S(=O)(=O)CC2CC(F)(F)C2)n1
Show InChI InChI=1S/C24H26F3N7O3S/c1-14(2)34-22(30-31-32-34)20-4-3-5-21(28-20)29-23(35)18-8-17-12-33(7-6-16(17)9-19(18)25)38(36,37)13-15-10-24(26,27)11-15/h3-5,8-9,14-15H,6-7,10-13H2,1-2H3,(H,28,29,35)
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Enanta Pharmaceuticals, Inc.

US Patent


Assay Description
HTRF KinEASE-STK is a generic method for measuring serine/threonine kinase activities using a time-resolved fluorescence resonance energy transfer (T...


US Patent US10450301 (2019)


BindingDB Entry DOI: 10.7270/Q2P84F7M
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM418938
PNG
(US10450301, Example 17)
Show SMILES CC(C)n1cnnc1-c1cccc(NC(=O)c2ccc3CN(Cc3c2)C(=O)N2CCCC2)n1
Show InChI InChI=1S/C24H27N7O2/c1-16(2)31-15-25-28-22(31)20-6-5-7-21(26-20)27-23(32)17-8-9-18-13-30(14-19(18)12-17)24(33)29-10-3-4-11-29/h5-9,12,15-16H,3-4,10-11,13-14H2,1-2H3,(H,26,27,32)
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Enanta Pharmaceuticals, Inc.

US Patent


Assay Description
HTRF KinEASE-STK is a generic method for measuring serine/threonine kinase activities using a time-resolved fluorescence resonance energy transfer (T...


US Patent US10450301 (2019)


BindingDB Entry DOI: 10.7270/Q2P84F7M
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM418961
PNG
(US10450301, Example 40)
Show SMILES CC(C)n1nnnc1-c1cccc(NC(=O)c2cc3CN(CCc3cc2F)S(=O)(=O)CCC(F)(F)F)n1
Show InChI InChI=1S/C22H23F4N7O3S/c1-13(2)33-20(29-30-31-33)18-4-3-5-19(27-18)28-21(34)16-10-15-12-32(8-6-14(15)11-17(16)23)37(35,36)9-7-22(24,25)26/h3-5,10-11,13H,6-9,12H2,1-2H3,(H,27,28,34)
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Enanta Pharmaceuticals, Inc.

US Patent


Assay Description
HTRF KinEASE-STK is a generic method for measuring serine/threonine kinase activities using a time-resolved fluorescence resonance energy transfer (T...


US Patent US10450301 (2019)


BindingDB Entry DOI: 10.7270/Q2P84F7M
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM418985
PNG
(US10450301, Example 64)
Show SMILES CC(C)n1cnnc1-c1cccc(NC(=O)c2ccc3CCN(Cc3c2)C(=O)OCCC=C)n1
Show InChI InChI=1S/C25H28N6O3/c1-4-5-13-34-25(33)30-12-11-18-9-10-19(14-20(18)15-30)24(32)28-22-8-6-7-21(27-22)23-29-26-16-31(23)17(2)3/h4,6-10,14,16-17H,1,5,11-13,15H2,2-3H3,(H,27,28,32)
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Enanta Pharmaceuticals, Inc.

US Patent


Assay Description
HTRF KinEASE-STK is a generic method for measuring serine/threonine kinase activities using a time-resolved fluorescence resonance energy transfer (T...


US Patent US10450301 (2019)


BindingDB Entry DOI: 10.7270/Q2P84F7M
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM418999
PNG
(US10450301, Example 78)
Show SMILES CC(C)n1nnnc1-c1cccc(NC(=O)c2cc3CN(CCc3cc2F)C(=O)N(C)C2CCCC2)n1
Show InChI InChI=1S/C26H31FN8O2/c1-16(2)35-24(30-31-32-35)22-9-6-10-23(28-22)29-25(36)20-13-18-15-34(12-11-17(18)14-21(20)27)26(37)33(3)19-7-4-5-8-19/h6,9-10,13-14,16,19H,4-5,7-8,11-12,15H2,1-3H3,(H,28,29,36)
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Enanta Pharmaceuticals, Inc.

US Patent


Assay Description
HTRF KinEASE-STK is a generic method for measuring serine/threonine kinase activities using a time-resolved fluorescence resonance energy transfer (T...


US Patent US10450301 (2019)


BindingDB Entry DOI: 10.7270/Q2P84F7M
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM419008
PNG
(US10450301, Example 87)
Show SMILES CC(C)n1nnnc1-c1cccc(NC(=O)c2cc3CN(CCc3cc2F)S(=O)(=O)CC2CC2)n1
Show InChI InChI=1S/C23H26FN7O3S/c1-14(2)31-22(27-28-29-31)20-4-3-5-21(25-20)26-23(32)18-10-17-12-30(9-8-16(17)11-19(18)24)35(33,34)13-15-6-7-15/h3-5,10-11,14-15H,6-9,12-13H2,1-2H3,(H,25,26,32)
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Enanta Pharmaceuticals, Inc.

US Patent


Assay Description
HTRF KinEASE-STK is a generic method for measuring serine/threonine kinase activities using a time-resolved fluorescence resonance energy transfer (T...


US Patent US10450301 (2019)


BindingDB Entry DOI: 10.7270/Q2P84F7M
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM419027
PNG
(US10450301, Example 106)
Show SMILES CC(C)n1nnnc1-c1cccc(NC(=O)c2cc3CN(CCc3cc2F)C(=O)N2C[C@H](C)O[C@H](C)C2)n1
Show InChI InChI=1S/C26H31FN8O3/c1-15(2)35-24(30-31-32-35)22-6-5-7-23(28-22)29-25(36)20-10-19-14-33(9-8-18(19)11-21(20)27)26(37)34-12-16(3)38-17(4)13-34/h5-7,10-11,15-17H,8-9,12-14H2,1-4H3,(H,28,29,36)/t16-,17+
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Enanta Pharmaceuticals, Inc.

US Patent


Assay Description
HTRF KinEASE-STK is a generic method for measuring serine/threonine kinase activities using a time-resolved fluorescence resonance energy transfer (T...


US Patent US10450301 (2019)


BindingDB Entry DOI: 10.7270/Q2P84F7M
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM419100
PNG
(US10450301, Example 179)
Show SMILES CC(C)n1cnnc1-c1cccc(NC(=O)c2cc3CN(Cc3cn2)C(=O)OCc2ccccc2)n1
Show InChI InChI=1S/C26H25N7O3/c1-17(2)33-16-28-31-24(33)21-9-6-10-23(29-21)30-25(34)22-11-19-13-32(14-20(19)12-27-22)26(35)36-15-18-7-4-3-5-8-18/h3-12,16-17H,13-15H2,1-2H3,(H,29,30,34)
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Enanta Pharmaceuticals, Inc.

US Patent


Assay Description
HTRF KinEASE-STK is a generic method for measuring serine/threonine kinase activities using a time-resolved fluorescence resonance energy transfer (T...


US Patent US10450301 (2019)


BindingDB Entry DOI: 10.7270/Q2P84F7M
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM418940
PNG
(US10450301, Example 19)
Show SMILES CC(C)N1Cc2cnc(cc2C1=O)C(=O)Nc1cccc(n1)-c1nncn1C(C)C
Show InChI InChI=1S/C21H23N7O2/c1-12(2)27-10-14-9-22-17(8-15(14)21(27)30)20(29)25-18-7-5-6-16(24-18)19-26-23-11-28(19)13(3)4/h5-9,11-13H,10H2,1-4H3,(H,24,25,29)
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Enanta Pharmaceuticals, Inc.

US Patent


Assay Description
HTRF KinEASE-STK is a generic method for measuring serine/threonine kinase activities using a time-resolved fluorescence resonance energy transfer (T...


US Patent US10450301 (2019)


BindingDB Entry DOI: 10.7270/Q2P84F7M
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM418948
PNG
(US10450301, Example 27)
Show SMILES CC(C)n1cnnc1-c1cccc(NC(=O)c2cc3CNCCc3cc2F)n1
Show InChI InChI=1S/C20H21FN6O/c1-12(2)27-11-23-26-19(27)17-4-3-5-18(24-17)25-20(28)15-8-14-10-22-7-6-13(14)9-16(15)21/h3-5,8-9,11-12,22H,6-7,10H2,1-2H3,(H,24,25,28)
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Enanta Pharmaceuticals, Inc.

US Patent


Assay Description
HTRF KinEASE-STK is a generic method for measuring serine/threonine kinase activities using a time-resolved fluorescence resonance energy transfer (T...


US Patent US10450301 (2019)


BindingDB Entry DOI: 10.7270/Q2P84F7M
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM418956
PNG
(US10450301, Example 35)
Show SMILES CCCOC(=O)N1CCc2ccc(cc2C1)C(=O)Nc1cccc(n1)-c1nncn1C(C)C
Show InChI InChI=1S/C24H28N6O3/c1-4-12-33-24(32)29-11-10-17-8-9-18(13-19(17)14-29)23(31)27-21-7-5-6-20(26-21)22-28-25-15-30(22)16(2)3/h5-9,13,15-16H,4,10-12,14H2,1-3H3,(H,26,27,31)
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Enanta Pharmaceuticals, Inc.

US Patent


Assay Description
HTRF KinEASE-STK is a generic method for measuring serine/threonine kinase activities using a time-resolved fluorescence resonance energy transfer (T...


US Patent US10450301 (2019)


BindingDB Entry DOI: 10.7270/Q2P84F7M
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM418976
PNG
(US10450301, Example 55)
Show SMILES COCCS(=O)(=O)N1CCc2cc(F)c(cc2C1)C(=O)Nc1cccc(n1)-c1nnnn1C(C)C
Show InChI InChI=1S/C22H26FN7O4S/c1-14(2)30-21(26-27-28-30)19-5-4-6-20(24-19)25-22(31)17-11-16-13-29(35(32,33)10-9-34-3)8-7-15(16)12-18(17)23/h4-6,11-12,14H,7-10,13H2,1-3H3,(H,24,25,31)
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Enanta Pharmaceuticals, Inc.

US Patent


Assay Description
HTRF KinEASE-STK is a generic method for measuring serine/threonine kinase activities using a time-resolved fluorescence resonance energy transfer (T...


US Patent US10450301 (2019)


BindingDB Entry DOI: 10.7270/Q2P84F7M
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM418990
PNG
(US10450301, Example 69)
Show SMILES CC(C)n1nnnc1-c1cccc(NC(=O)c2cc3C(C)N(CCc3cc2F)C(=O)N2CCCC2)n1
Show InChI InChI=1S/C25H29FN8O2/c1-15(2)34-23(29-30-31-34)21-7-6-8-22(27-21)28-24(35)19-14-18-16(3)33(12-9-17(18)13-20(19)26)25(36)32-10-4-5-11-32/h6-8,13-16H,4-5,9-12H2,1-3H3,(H,27,28,35)
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Enanta Pharmaceuticals, Inc.

US Patent


Assay Description
HTRF KinEASE-STK is a generic method for measuring serine/threonine kinase activities using a time-resolved fluorescence resonance energy transfer (T...


US Patent US10450301 (2019)


BindingDB Entry DOI: 10.7270/Q2P84F7M
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM419012
PNG
(US10450301, Example 91)
Show SMILES CC(C)n1nnnc1-c1cccc(NC(=O)c2cc3CN(CCc3cc2F)C(=O)N2CCN(C)CC2)n1
Show InChI InChI=1S/C25H30FN9O2/c1-16(2)35-23(29-30-31-35)21-5-4-6-22(27-21)28-24(36)19-13-18-15-34(8-7-17(18)14-20(19)26)25(37)33-11-9-32(3)10-12-33/h4-6,13-14,16H,7-12,15H2,1-3H3,(H,27,28,36)
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Enanta Pharmaceuticals, Inc.

US Patent


Assay Description
HTRF KinEASE-STK is a generic method for measuring serine/threonine kinase activities using a time-resolved fluorescence resonance energy transfer (T...


US Patent US10450301 (2019)


BindingDB Entry DOI: 10.7270/Q2P84F7M
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM419024
PNG
(US10450301, Example 103 | US10450301, Example 104)
Show SMILES CC(C)n1nnnc1-c1cccc(NC(=O)c2cc3CN(CCc3cc2F)C(=O)N2CCS(=O)(=O)CC2)n1
Show InChI InChI=1S/C24H27FN8O4S/c1-15(2)33-22(28-29-30-33)20-4-3-5-21(26-20)27-23(34)18-12-17-14-32(7-6-16(17)13-19(18)25)24(35)31-8-10-38(36,37)11-9-31/h3-5,12-13,15H,6-11,14H2,1-2H3,(H,26,27,34)
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Enanta Pharmaceuticals, Inc.

US Patent


Assay Description
HTRF KinEASE-STK is a generic method for measuring serine/threonine kinase activities using a time-resolved fluorescence resonance energy transfer (T...


US Patent US10450301 (2019)


BindingDB Entry DOI: 10.7270/Q2P84F7M
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM419032
PNG
(US10450301, Example 111)
Show SMILES CC(C)n1nnnc1-c1cccc(NC(=O)c2cc3CN(CCc3cn2)S(=O)(=O)N(C)C)n1
Show InChI InChI=1S/C20H25N9O3S/c1-13(2)29-19(24-25-26-29)16-6-5-7-18(22-16)23-20(30)17-10-15-12-28(33(31,32)27(3)4)9-8-14(15)11-21-17/h5-7,10-11,13H,8-9,12H2,1-4H3,(H,22,23,30)
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Enanta Pharmaceuticals, Inc.

US Patent


Assay Description
HTRF KinEASE-STK is a generic method for measuring serine/threonine kinase activities using a time-resolved fluorescence resonance energy transfer (T...


US Patent US10450301 (2019)


BindingDB Entry DOI: 10.7270/Q2P84F7M
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM418977
PNG
(US10450301, Example 56)
Show SMILES CC(C)n1nnnc1-c1cccc(NC(=O)c2cc3CN(CCc3cc2F)C(=O)NC2CCCC2)n1
Show InChI InChI=1S/C25H29FN8O2/c1-15(2)34-23(30-31-32-34)21-8-5-9-22(28-21)29-24(35)19-12-17-14-33(11-10-16(17)13-20(19)26)25(36)27-18-6-3-4-7-18/h5,8-9,12-13,15,18H,3-4,6-7,10-11,14H2,1-2H3,(H,27,36)(H,28,29,35)
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Enanta Pharmaceuticals, Inc.

US Patent


Assay Description
HTRF KinEASE-STK is a generic method for measuring serine/threonine kinase activities using a time-resolved fluorescence resonance energy transfer (T...


US Patent US10450301 (2019)


BindingDB Entry DOI: 10.7270/Q2P84F7M
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM418982
PNG
(US10450301, Example 61)
Show SMILES CC(C)n1cnnc1-c1cccc(NC(=O)c2ccc3CCN(Cc3c2)C(=O)NC2CCCC2)n1
Show InChI InChI=1S/C26H31N7O2/c1-17(2)33-16-27-31-24(33)22-8-5-9-23(29-22)30-25(34)19-11-10-18-12-13-32(15-20(18)14-19)26(35)28-21-6-3-4-7-21/h5,8-11,14,16-17,21H,3-4,6-7,12-13,15H2,1-2H3,(H,28,35)(H,29,30,34)
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Enanta Pharmaceuticals, Inc.

US Patent


Assay Description
HTRF KinEASE-STK is a generic method for measuring serine/threonine kinase activities using a time-resolved fluorescence resonance energy transfer (T...


US Patent US10450301 (2019)


BindingDB Entry DOI: 10.7270/Q2P84F7M
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM418986
PNG
(US10450301, Example 65)
Show SMILES CC(C)n1cnnc1-c1cccc(NC(=O)c2ccc3CCN(Cc3c2)C(=O)OCCF)n1
Show InChI InChI=1S/C23H25FN6O3/c1-15(2)30-14-25-28-21(30)19-4-3-5-20(26-19)27-22(31)17-7-6-16-8-10-29(13-18(16)12-17)23(32)33-11-9-24/h3-7,12,14-15H,8-11,13H2,1-2H3,(H,26,27,31)
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Enanta Pharmaceuticals, Inc.

US Patent


Assay Description
HTRF KinEASE-STK is a generic method for measuring serine/threonine kinase activities using a time-resolved fluorescence resonance energy transfer (T...


US Patent US10450301 (2019)


BindingDB Entry DOI: 10.7270/Q2P84F7M
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM419007
PNG
(US10450301, Example 86)
Show SMILES CC(C)CS(=O)(=O)N1CCc2cc(F)c(cc2C1)C(=O)Nc1cccc(n1)-c1nnnn1C(C)C
Show InChI InChI=1S/C23H28FN7O3S/c1-14(2)13-35(33,34)30-9-8-16-11-19(24)18(10-17(16)12-30)23(32)26-21-7-5-6-20(25-21)22-27-28-29-31(22)15(3)4/h5-7,10-11,14-15H,8-9,12-13H2,1-4H3,(H,25,26,32)
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Enanta Pharmaceuticals, Inc.

US Patent


Assay Description
HTRF KinEASE-STK is a generic method for measuring serine/threonine kinase activities using a time-resolved fluorescence resonance energy transfer (T...


US Patent US10450301 (2019)


BindingDB Entry DOI: 10.7270/Q2P84F7M
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM419013
PNG
(US10450301, Example 92)
Show SMILES CC(C)n1nnnc1-c1cccc(NC(=O)c2cc3CN(CCc3cc2F)C(=O)N2CCOCC2)n1
Show InChI InChI=1S/C24H27FN8O3/c1-15(2)33-22(28-29-30-33)20-4-3-5-21(26-20)27-23(34)18-12-17-14-32(7-6-16(17)13-19(18)25)24(35)31-8-10-36-11-9-31/h3-5,12-13,15H,6-11,14H2,1-2H3,(H,26,27,34)
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Enanta Pharmaceuticals, Inc.

US Patent


Assay Description
HTRF KinEASE-STK is a generic method for measuring serine/threonine kinase activities using a time-resolved fluorescence resonance energy transfer (T...


US Patent US10450301 (2019)


BindingDB Entry DOI: 10.7270/Q2P84F7M
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM418927
PNG
(US10450301, Example 6)
Show SMILES COCCS(=O)(=O)N1Cc2ccc(cc2C1)C(=O)Nc1cccc(n1)-c1nncn1C(C)C
Show InChI InChI=1S/C22H26N6O4S/c1-15(2)28-14-23-26-21(28)19-5-4-6-20(24-19)25-22(29)16-7-8-17-12-27(13-18(17)11-16)33(30,31)10-9-32-3/h4-8,11,14-15H,9-10,12-13H2,1-3H3,(H,24,25,29)
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Enanta Pharmaceuticals, Inc.

US Patent


Assay Description
HTRF KinEASE-STK is a generic method for measuring serine/threonine kinase activities using a time-resolved fluorescence resonance energy transfer (T...


US Patent US10450301 (2019)


BindingDB Entry DOI: 10.7270/Q2P84F7M
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM418932
PNG
(US10450301, Example 11)
Show SMILES CC(C)n1nnnc1-c1cccc(NC(=O)c2ccc3CN(Cc3c2)C(=O)N2CCCC2)n1
Show InChI InChI=1S/C23H26N8O2/c1-15(2)31-21(26-27-28-31)19-6-5-7-20(24-19)25-22(32)16-8-9-17-13-30(14-18(17)12-16)23(33)29-10-3-4-11-29/h5-9,12,15H,3-4,10-11,13-14H2,1-2H3,(H,24,25,32)
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Enanta Pharmaceuticals, Inc.

US Patent


Assay Description
HTRF KinEASE-STK is a generic method for measuring serine/threonine kinase activities using a time-resolved fluorescence resonance energy transfer (T...


US Patent US10450301 (2019)


BindingDB Entry DOI: 10.7270/Q2P84F7M
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM418926
PNG
(US10450301, Example 5)
Show SMILES CCN(C)C(=O)N1Cc2ccc(cc2C1)C(=O)Nc1cccc(n1)-c1nncn1C(C)C
Show InChI InChI=1S/C23H27N7O2/c1-5-28(4)23(32)29-12-17-10-9-16(11-18(17)13-29)22(31)26-20-8-6-7-19(25-20)21-27-24-14-30(21)15(2)3/h6-11,14-15H,5,12-13H2,1-4H3,(H,25,26,31)
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Enanta Pharmaceuticals, Inc.

US Patent


Assay Description
HTRF KinEASE-STK is a generic method for measuring serine/threonine kinase activities using a time-resolved fluorescence resonance energy transfer (T...


US Patent US10450301 (2019)


BindingDB Entry DOI: 10.7270/Q2P84F7M
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM419068
PNG
(US10450301, Example 147)
Show SMILES C[C@H](COC(C)=O)n1nnnc1-c1cccc(NC(=O)c2cc3CN(CCc3cn2)C(=O)OC(C)(C)C)n1
Show InChI InChI=1S/C25H30N8O5/c1-15(14-37-16(2)34)33-22(29-30-31-33)19-7-6-8-21(27-19)28-23(35)20-11-18-13-32(10-9-17(18)12-26-20)24(36)38-25(3,4)5/h6-8,11-12,15H,9-10,13-14H2,1-5H3,(H,27,28,35)/t15-/m1/s1
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Enanta Pharmaceuticals, Inc.

US Patent


Assay Description
HTRF KinEASE-STK is a generic method for measuring serine/threonine kinase activities using a time-resolved fluorescence resonance energy transfer (T...


US Patent US10450301 (2019)


BindingDB Entry DOI: 10.7270/Q2P84F7M
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM419020
PNG
(US10450301, Example 99)
Show SMILES CC(C)c1nnnn1-c1cccc(NC(=O)c2cc3CN(CCc3cc2F)C(=O)N(C)CCC(F)(F)F)n1
Show InChI InChI=1S/C24H26F4N8O2/c1-14(2)21-31-32-33-36(21)20-6-4-5-19(29-20)30-22(37)17-11-16-13-35(9-7-15(16)12-18(17)25)23(38)34(3)10-8-24(26,27)28/h4-6,11-12,14H,7-10,13H2,1-3H3,(H,29,30,37)
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Enanta Pharmaceuticals, Inc.

US Patent


Assay Description
HTRF KinEASE-STK is a generic method for measuring serine/threonine kinase activities using a time-resolved fluorescence resonance energy transfer (T...


US Patent US10450301 (2019)


BindingDB Entry DOI: 10.7270/Q2P84F7M
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM418989
PNG
(US10450301, Example 68)
Show SMILES CC(C)n1nnnc1-c1cccc(NC(=O)c2cc3C(C)NCCc3cc2F)n1
Show InChI InChI=1S/C20H22FN7O/c1-11(2)28-19(25-26-27-28)17-5-4-6-18(23-17)24-20(29)15-10-14-12(3)22-8-7-13(14)9-16(15)21/h4-6,9-12,22H,7-8H2,1-3H3,(H,23,24,29)
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Enanta Pharmaceuticals, Inc.

US Patent


Assay Description
HTRF KinEASE-STK is a generic method for measuring serine/threonine kinase activities using a time-resolved fluorescence resonance energy transfer (T...


US Patent US10450301 (2019)


BindingDB Entry DOI: 10.7270/Q2P84F7M
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM418928
PNG
(US10450301, Example 7)
Show SMILES CCOC(=O)N1Cc2ccc(cc2C1)C(=O)Nc1cccc(n1)-c1nncn1C(C)C
Show InChI InChI=1S/C22H24N6O3/c1-4-31-22(30)27-11-16-9-8-15(10-17(16)12-27)21(29)25-19-7-5-6-18(24-19)20-26-23-13-28(20)14(2)3/h5-10,13-14H,4,11-12H2,1-3H3,(H,24,25,29)
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Enanta Pharmaceuticals, Inc.

US Patent


Assay Description
HTRF KinEASE-STK is a generic method for measuring serine/threonine kinase activities using a time-resolved fluorescence resonance energy transfer (T...


US Patent US10450301 (2019)


BindingDB Entry DOI: 10.7270/Q2P84F7M
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM418925
PNG
(US10450301, Example 4)
Show SMILES CC(C)n1cnnc1-c1cccc(NC(=O)c2ccc3CN(Cc3c2)S(=O)(=O)CCC(F)(F)F)n1
Show InChI InChI=1S/C22H23F3N6O3S/c1-14(2)31-13-26-29-20(31)18-4-3-5-19(27-18)28-21(32)15-6-7-16-11-30(12-17(16)10-15)35(33,34)9-8-22(23,24)25/h3-7,10,13-14H,8-9,11-12H2,1-2H3,(H,27,28,32)
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Enanta Pharmaceuticals, Inc.

US Patent


Assay Description
HTRF KinEASE-STK is a generic method for measuring serine/threonine kinase activities using a time-resolved fluorescence resonance energy transfer (T...


US Patent US10450301 (2019)


BindingDB Entry DOI: 10.7270/Q2P84F7M
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM418922
PNG
(US10450301, Example 1)
Show SMILES CC(C)N1Cc2ccc(cc2C1=O)C(=O)Nc1cccc(n1)-c1nnnn1C(C)C
Show InChI InChI=1S/C21H23N7O2/c1-12(2)27-11-15-9-8-14(10-16(15)21(27)30)20(29)23-18-7-5-6-17(22-18)19-24-25-26-28(19)13(3)4/h5-10,12-13H,11H2,1-4H3,(H,22,23,29)
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Enanta Pharmaceuticals, Inc.

US Patent


Assay Description
HTRF KinEASE-STK is a generic method for measuring serine/threonine kinase activities using a time-resolved fluorescence resonance energy transfer (T...


US Patent US10450301 (2019)


BindingDB Entry DOI: 10.7270/Q2P84F7M
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM418959
PNG
(US10450301, Example 38)
Show SMILES COCCCN1CCc2ccc(cc2C1)C(=O)Nc1cccc(n1)-c1nncn1C(C)C
Show InChI InChI=1S/C24H30N6O2/c1-17(2)30-16-25-28-23(30)21-6-4-7-22(26-21)27-24(31)19-9-8-18-10-12-29(11-5-13-32-3)15-20(18)14-19/h4,6-9,14,16-17H,5,10-13,15H2,1-3H3,(H,26,27,31)
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Enanta Pharmaceuticals, Inc.

US Patent


Assay Description
HTRF KinEASE-STK is a generic method for measuring serine/threonine kinase activities using a time-resolved fluorescence resonance energy transfer (T...


US Patent US10450301 (2019)


BindingDB Entry DOI: 10.7270/Q2P84F7M
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM418958
PNG
(US10450301, Example 37)
Show SMILES CC(C)n1cnnc1-c1cccc(NC(=O)c2ccc3CCNCc3c2)n1
Show InChI InChI=1S/C20H22N6O/c1-13(2)26-12-22-25-19(26)17-4-3-5-18(23-17)24-20(27)15-7-6-14-8-9-21-11-16(14)10-15/h3-7,10,12-13,21H,8-9,11H2,1-2H3,(H,23,24,27)
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Enanta Pharmaceuticals, Inc.

US Patent


Assay Description
HTRF KinEASE-STK is a generic method for measuring serine/threonine kinase activities using a time-resolved fluorescence resonance energy transfer (T...


US Patent US10450301 (2019)


BindingDB Entry DOI: 10.7270/Q2P84F7M
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM419095
PNG
(US10450301, Example 174)
Show SMILES COc1cc2CN(C(C)C)C(=O)c2cc1C(=O)Nc1cccc(n1)-c1nnnn1C(C)C
Show InChI InChI=1S/C22H25N7O3/c1-12(2)28-11-14-9-18(32-5)16(10-15(14)22(28)31)21(30)24-19-8-6-7-17(23-19)20-25-26-27-29(20)13(3)4/h6-10,12-13H,11H2,1-5H3,(H,23,24,30)
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Enanta Pharmaceuticals, Inc.

US Patent


Assay Description
HTRF KinEASE-STK is a generic method for measuring serine/threonine kinase activities using a time-resolved fluorescence resonance energy transfer (T...


US Patent US10450301 (2019)


BindingDB Entry DOI: 10.7270/Q2P84F7M
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM418995
PNG
(US10450301, Example 74)
Show SMILES CC(C)n1nnnc1-c1cccc(NC(=O)c2cc3C(C)N(CCc3cc2F)C(=O)OCc2ccccc2)n1
Show InChI InChI=1S/C28H28FN7O3/c1-17(2)36-26(32-33-34-36)24-10-7-11-25(30-24)31-27(37)22-15-21-18(3)35(13-12-20(21)14-23(22)29)28(38)39-16-19-8-5-4-6-9-19/h4-11,14-15,17-18H,12-13,16H2,1-3H3,(H,30,31,37)
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Enanta Pharmaceuticals, Inc.

US Patent


Assay Description
HTRF KinEASE-STK is a generic method for measuring serine/threonine kinase activities using a time-resolved fluorescence resonance energy transfer (T...


US Patent US10450301 (2019)


BindingDB Entry DOI: 10.7270/Q2P84F7M
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM418979
PNG
(US10450301, Example 58)
Show SMILES CC(C)n1nnnc1-c1cccc(NC(=O)c2cc3CNCCc3cc2F)n1
Show InChI InChI=1S/C19H20FN7O/c1-11(2)27-18(24-25-26-27)16-4-3-5-17(22-16)23-19(28)14-8-13-10-21-7-6-12(13)9-15(14)20/h3-5,8-9,11,21H,6-7,10H2,1-2H3,(H,22,23,28)
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Enanta Pharmaceuticals, Inc.

US Patent


Assay Description
HTRF KinEASE-STK is a generic method for measuring serine/threonine kinase activities using a time-resolved fluorescence resonance energy transfer (T...


US Patent US10450301 (2019)


BindingDB Entry DOI: 10.7270/Q2P84F7M
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM418960
PNG
(US10450301, Example 39)
Show SMILES CC(C)n1cnnc1-c1cccc(NC(=O)c2ccc3CCN(CC=C)Cc3c2)n1
Show InChI InChI=1S/C23H26N6O/c1-4-11-28-12-10-17-8-9-18(13-19(17)14-28)23(30)26-21-7-5-6-20(25-21)22-27-24-15-29(22)16(2)3/h4-9,13,15-16H,1,10-12,14H2,2-3H3,(H,25,26,30)
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Enanta Pharmaceuticals, Inc.

US Patent


Assay Description
HTRF KinEASE-STK is a generic method for measuring serine/threonine kinase activities using a time-resolved fluorescence resonance energy transfer (T...


US Patent US10450301 (2019)


BindingDB Entry DOI: 10.7270/Q2P84F7M
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM419029
PNG
(US10450301, Example 108)
Show SMILES CC(C)n1nnnc1-c1cccc(NC(=O)c2cc3C(C)N(CC(=O)N4CCCC4)CCc3cc2F)n1
Show InChI InChI=1S/C26H31FN8O2/c1-16(2)35-25(30-31-32-35)22-7-6-8-23(28-22)29-26(37)20-14-19-17(3)34(12-9-18(19)13-21(20)27)15-24(36)33-10-4-5-11-33/h6-8,13-14,16-17H,4-5,9-12,15H2,1-3H3,(H,28,29,37)
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Enanta Pharmaceuticals, Inc.

US Patent


Assay Description
HTRF KinEASE-STK is a generic method for measuring serine/threonine kinase activities using a time-resolved fluorescence resonance energy transfer (T...


US Patent US10450301 (2019)


BindingDB Entry DOI: 10.7270/Q2P84F7M
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM418933
PNG
(US10450301, Example 12)
Show SMILES CC(C)n1nnnc1-c1cccc(NC(=O)c2ccc3CN(Cc3c2)C(=O)N(C)C)n1
Show InChI InChI=1S/C21H24N8O2/c1-13(2)29-19(24-25-26-29)17-6-5-7-18(22-17)23-20(30)14-8-9-15-11-28(12-16(15)10-14)21(31)27(3)4/h5-10,13H,11-12H2,1-4H3,(H,22,23,30)
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Enanta Pharmaceuticals, Inc.

US Patent


Assay Description
HTRF KinEASE-STK is a generic method for measuring serine/threonine kinase activities using a time-resolved fluorescence resonance energy transfer (T...


US Patent US10450301 (2019)


BindingDB Entry DOI: 10.7270/Q2P84F7M
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM418937
PNG
(US10450301, Example 16)
Show SMILES CCOC(=O)N1Cc2ccc(cc2C1)C(=O)Nc1cccc(n1)-c1nnnn1C(C)C
Show InChI InChI=1S/C21H23N7O3/c1-4-31-21(30)27-11-15-9-8-14(10-16(15)12-27)20(29)23-18-7-5-6-17(22-18)19-24-25-26-28(19)13(2)3/h5-10,13H,4,11-12H2,1-3H3,(H,22,23,29)
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Enanta Pharmaceuticals, Inc.

US Patent


Assay Description
HTRF KinEASE-STK is a generic method for measuring serine/threonine kinase activities using a time-resolved fluorescence resonance energy transfer (T...


US Patent US10450301 (2019)


BindingDB Entry DOI: 10.7270/Q2P84F7M
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM419097
PNG
(US10450301, Example 176)
Show SMILES CC(C)N1Cc2cc(F)c(cc2C1=O)C(=O)Nc1cccc(n1)-c1nnnn1C(C)C
Show InChI InChI=1S/C21H22FN7O2/c1-11(2)28-10-13-8-16(22)15(9-14(13)21(28)31)20(30)24-18-7-5-6-17(23-18)19-25-26-27-29(19)12(3)4/h5-9,11-12H,10H2,1-4H3,(H,23,24,30)
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Enanta Pharmaceuticals, Inc.

US Patent


Assay Description
HTRF KinEASE-STK is a generic method for measuring serine/threonine kinase activities using a time-resolved fluorescence resonance energy transfer (T...


US Patent US10450301 (2019)


BindingDB Entry DOI: 10.7270/Q2P84F7M
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM418994
PNG
(US10450301, Example 73)
Show SMILES C[C@H](COC(C)=O)n1nnnc1-c1cccc(NC(=O)c2cc3CN(CCc3cc2F)C(=O)N2CCCC2)n1
Show InChI InChI=1S/C26H29FN8O4/c1-16(15-39-17(2)36)35-24(30-31-32-35)22-6-5-7-23(28-22)29-25(37)20-12-19-14-34(11-8-18(19)13-21(20)27)26(38)33-9-3-4-10-33/h5-7,12-13,16H,3-4,8-11,14-15H2,1-2H3,(H,28,29,37)/t16-/m1/s1
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Enanta Pharmaceuticals, Inc.

US Patent


Assay Description
HTRF KinEASE-STK is a generic method for measuring serine/threonine kinase activities using a time-resolved fluorescence resonance energy transfer (T...


US Patent US10450301 (2019)


BindingDB Entry DOI: 10.7270/Q2P84F7M
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM419019
PNG
(US10450301, Example 98)
Show SMILES CCN1CCc2cc(F)c(cc2C1=O)C(=O)Nc1cccc(n1)-c1nnnn1C(C)C
Show InChI InChI=1S/C21H22FN7O2/c1-4-28-9-8-13-10-16(22)15(11-14(13)21(28)31)20(30)24-18-7-5-6-17(23-18)19-25-26-27-29(19)12(2)3/h5-7,10-12H,4,8-9H2,1-3H3,(H,23,24,30)
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Enanta Pharmaceuticals, Inc.

US Patent


Assay Description
HTRF KinEASE-STK is a generic method for measuring serine/threonine kinase activities using a time-resolved fluorescence resonance energy transfer (T...


US Patent US10450301 (2019)


BindingDB Entry DOI: 10.7270/Q2P84F7M
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM419101
PNG
(US10450301, Example 180)
Show SMILES CC(C)n1nnnc1-c1cccc(NC(=O)c2cc3CN(Cc3cn2)C(=O)OCc2ccccc2)n1
Show InChI InChI=1S/C25H24N8O3/c1-16(2)33-23(29-30-31-33)20-9-6-10-22(27-20)28-24(34)21-11-18-13-32(14-19(18)12-26-21)25(35)36-15-17-7-4-3-5-8-17/h3-12,16H,13-15H2,1-2H3,(H,27,28,34)
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Enanta Pharmaceuticals, Inc.

US Patent


Assay Description
HTRF KinEASE-STK is a generic method for measuring serine/threonine kinase activities using a time-resolved fluorescence resonance energy transfer (T...


US Patent US10450301 (2019)


BindingDB Entry DOI: 10.7270/Q2P84F7M
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM418993
PNG
(US10450301, Example 72)
Show SMILES C[C@H](COC(C)=O)n1nnnc1-c1cccc(NC(=O)c2cc3CN(CCc3cc2F)C(=O)N(C)CC(F)(F)F)n1
Show InChI InChI=1S/C25H26F4N8O4/c1-14(12-41-15(2)38)37-22(32-33-34-37)20-5-4-6-21(30-20)31-23(39)18-9-17-11-36(8-7-16(17)10-19(18)26)24(40)35(3)13-25(27,28)29/h4-6,9-10,14H,7-8,11-13H2,1-3H3,(H,30,31,39)/t14-/m1/s1
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Enanta Pharmaceuticals, Inc.

US Patent


Assay Description
HTRF KinEASE-STK is a generic method for measuring serine/threonine kinase activities using a time-resolved fluorescence resonance energy transfer (T...


US Patent US10450301 (2019)


BindingDB Entry DOI: 10.7270/Q2P84F7M
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM419112
PNG
(US10450301, Example 183a)
Show SMILES CC(C)n1cnnc1-c1cccc(NC(=O)c2ccc3CCN(Cc3c2)C(=O)OC(C)(C)C)n1
Show InChI InChI=1S/C25H30N6O3/c1-16(2)31-15-26-29-22(31)20-7-6-8-21(27-20)28-23(32)18-10-9-17-11-12-30(14-19(17)13-18)24(33)34-25(3,4)5/h6-10,13,15-16H,11-12,14H2,1-5H3,(H,27,28,32)
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Enanta Pharmaceuticals, Inc.

US Patent


Assay Description
HTRF KinEASE-STK is a generic method for measuring serine/threonine kinase activities using a time-resolved fluorescence resonance energy transfer (T...


US Patent US10450301 (2019)


BindingDB Entry DOI: 10.7270/Q2P84F7M
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM418936
PNG
(US10450301, Example 15)
Show SMILES COCCS(=O)(=O)N1Cc2ccc(cc2C1)C(=O)Nc1cccc(n1)-c1nnnn1C(C)C
Show InChI InChI=1S/C21H25N7O4S/c1-14(2)28-20(24-25-26-28)18-5-4-6-19(22-18)23-21(29)15-7-8-16-12-27(13-17(16)11-15)33(30,31)10-9-32-3/h4-8,11,14H,9-10,12-13H2,1-3H3,(H,22,23,29)
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Enanta Pharmaceuticals, Inc.

US Patent


Assay Description
HTRF KinEASE-STK is a generic method for measuring serine/threonine kinase activities using a time-resolved fluorescence resonance energy transfer (T...


US Patent US10450301 (2019)


BindingDB Entry DOI: 10.7270/Q2P84F7M
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM418935
PNG
(US10450301, Example 14)
Show SMILES CC(C)n1nnnc1-c1cccc(NC(=O)c2ccc3CN(Cc3c2)S(=O)(=O)CCC(F)(F)F)n1
Show InChI InChI=1S/C21H22F3N7O3S/c1-13(2)31-19(27-28-29-31)17-4-3-5-18(25-17)26-20(32)14-6-7-15-11-30(12-16(15)10-14)35(33,34)9-8-21(22,23)24/h3-7,10,13H,8-9,11-12H2,1-2H3,(H,25,26,32)
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Enanta Pharmaceuticals, Inc.

US Patent


Assay Description
HTRF KinEASE-STK is a generic method for measuring serine/threonine kinase activities using a time-resolved fluorescence resonance energy transfer (T...


US Patent US10450301 (2019)


BindingDB Entry DOI: 10.7270/Q2P84F7M
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM418934
PNG
(US10450301, Example 13)
Show SMILES CCN(C)C(=O)N1Cc2ccc(cc2C1)C(=O)Nc1cccc(n1)-c1nnnn1C(C)C
Show InChI InChI=1S/C22H26N8O2/c1-5-28(4)22(32)29-12-16-10-9-15(11-17(16)13-29)21(31)24-19-8-6-7-18(23-19)20-25-26-27-30(20)14(2)3/h6-11,14H,5,12-13H2,1-4H3,(H,23,24,31)
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Enanta Pharmaceuticals, Inc.

US Patent


Assay Description
HTRF KinEASE-STK is a generic method for measuring serine/threonine kinase activities using a time-resolved fluorescence resonance energy transfer (T...


US Patent US10450301 (2019)


BindingDB Entry DOI: 10.7270/Q2P84F7M
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM418930
PNG
(US10450301, Example 9)
Show SMILES CC(C)n1cnnc1-c1cccc(NC(=O)c2ccc3CNCc3c2)n1
Show InChI InChI=1S/C19H20N6O/c1-12(2)25-11-21-24-18(25)16-4-3-5-17(22-16)23-19(26)13-6-7-14-9-20-10-15(14)8-13/h3-8,11-12,20H,9-10H2,1-2H3,(H,22,23,26)
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Enanta Pharmaceuticals, Inc.

US Patent


Assay Description
HTRF KinEASE-STK is a generic method for measuring serine/threonine kinase activities using a time-resolved fluorescence resonance energy transfer (T...


US Patent US10450301 (2019)


BindingDB Entry DOI: 10.7270/Q2P84F7M
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM418929
PNG
(US10450301, Example 8)
Show SMILES CC(C)n1nnnc1-c1cccc(NC(=O)c2ccc3CNCc3c2)n1
Show InChI InChI=1S/C18H19N7O/c1-11(2)25-17(22-23-24-25)15-4-3-5-16(20-15)21-18(26)12-6-7-13-9-19-10-14(13)8-12/h3-8,11,19H,9-10H2,1-2H3,(H,20,21,26)
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Enanta Pharmaceuticals, Inc.

US Patent


Assay Description
HTRF KinEASE-STK is a generic method for measuring serine/threonine kinase activities using a time-resolved fluorescence resonance energy transfer (T...


US Patent US10450301 (2019)


BindingDB Entry DOI: 10.7270/Q2P84F7M
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM418923
PNG
(US10450301, Example 2)
Show SMILES CC(C)n1nnnc1-c1cccc(NC(=O)c2ccc3CN(Cc3c2)C(=O)OCc2ccccc2)n1
Show InChI InChI=1S/C26H25N7O3/c1-17(2)33-24(29-30-31-33)22-9-6-10-23(27-22)28-25(34)19-11-12-20-14-32(15-21(20)13-19)26(35)36-16-18-7-4-3-5-8-18/h3-13,17H,14-16H2,1-2H3,(H,27,28,34)
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Enanta Pharmaceuticals, Inc.

US Patent


Assay Description
HTRF KinEASE-STK is a generic method for measuring serine/threonine kinase activities using a time-resolved fluorescence resonance energy transfer (T...


US Patent US10450301 (2019)


BindingDB Entry DOI: 10.7270/Q2P84F7M
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM419105
PNG
(US10450301, Example 184)
Show SMILES C[C@H](CO)n1nnnc1-c1cccc(NC(=O)c2cc3CN(CCc3cn2)C(=O)N(C)C2CCCC2)n1
Show InChI InChI=1S/C25H31N9O3/c1-16(15-35)34-23(29-30-31-34)20-8-5-9-22(27-20)28-24(36)21-12-18-14-33(11-10-17(18)13-26-21)25(37)32(2)19-6-3-4-7-19/h5,8-9,12-13,16,19,35H,3-4,6-7,10-11,14-15H2,1-2H3,(H,27,28,36)/t16-/m1/s1
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Enanta Pharmaceuticals, Inc.

US Patent


Assay Description
HTRF KinEASE-STK is a generic method for measuring serine/threonine kinase activities using a time-resolved fluorescence resonance energy transfer (T...


US Patent US10450301 (2019)


BindingDB Entry DOI: 10.7270/Q2P84F7M
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM419098
PNG
(US10450301, Example 177)
Show SMILES CC(C)N1Cc2cc(F)c(cc2C1=O)C(=O)Nc1cccc(n1)-c1nncn1C(C)C
Show InChI InChI=1S/C22H23FN6O2/c1-12(2)28-10-14-8-17(23)16(9-15(14)22(28)31)21(30)26-19-7-5-6-18(25-19)20-27-24-11-29(20)13(3)4/h5-9,11-13H,10H2,1-4H3,(H,25,26,30)
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Enanta Pharmaceuticals, Inc.

US Patent


Assay Description
HTRF KinEASE-STK is a generic method for measuring serine/threonine kinase activities using a time-resolved fluorescence resonance energy transfer (T...


US Patent US10450301 (2019)


BindingDB Entry DOI: 10.7270/Q2P84F7M
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM419030
PNG
(US10450301, Example 109)
Show SMILES C[C@H](COC(C)=O)n1nnnc1-c1cccc(NC(=O)c2cc3CN(CCc3cc2F)C(=O)OCc2ccccc2)n1
Show InChI InChI=1S/C29H28FN7O5/c1-18(16-41-19(2)38)37-27(33-34-35-37)25-9-6-10-26(31-25)32-28(39)23-13-22-15-36(12-11-21(22)14-24(23)30)29(40)42-17-20-7-4-3-5-8-20/h3-10,13-14,18H,11-12,15-17H2,1-2H3,(H,31,32,39)/t18-/m1/s1
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Enanta Pharmaceuticals, Inc.

US Patent


Assay Description
HTRF KinEASE-STK is a generic method for measuring serine/threonine kinase activities using a time-resolved fluorescence resonance energy transfer (T...


US Patent US10450301 (2019)


BindingDB Entry DOI: 10.7270/Q2P84F7M
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM419021
PNG
(US10450301, Example 100)
Show SMILES CC(C)c1nnnn1-c1cccc(NC(=O)c2cc3CN(CCc3cc2F)S(=O)(=O)CCC(F)(F)F)n1
Show InChI InChI=1S/C22H23F4N7O3S/c1-13(2)20-29-30-31-33(20)19-5-3-4-18(27-19)28-21(34)16-10-15-12-32(8-6-14(15)11-17(16)23)37(35,36)9-7-22(24,25)26/h3-5,10-11,13H,6-9,12H2,1-2H3,(H,27,28,34)
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Enanta Pharmaceuticals, Inc.

US Patent


Assay Description
HTRF KinEASE-STK is a generic method for measuring serine/threonine kinase activities using a time-resolved fluorescence resonance energy transfer (T...


US Patent US10450301 (2019)


BindingDB Entry DOI: 10.7270/Q2P84F7M
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM419009
PNG
(US10450301, Example 88)
Show SMILES CC(C)n1nnnc1-c1cccc(NC(=O)c2cc3CN(CCc3cc2F)S(=O)(=O)C2CC2)n1
Show InChI InChI=1S/C22H24FN7O3S/c1-13(2)30-21(26-27-28-30)19-4-3-5-20(24-19)25-22(31)17-10-15-12-29(34(32,33)16-6-7-16)9-8-14(15)11-18(17)23/h3-5,10-11,13,16H,6-9,12H2,1-2H3,(H,24,25,31)
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Enanta Pharmaceuticals, Inc.

US Patent


Assay Description
HTRF KinEASE-STK is a generic method for measuring serine/threonine kinase activities using a time-resolved fluorescence resonance energy transfer (T...


US Patent US10450301 (2019)


BindingDB Entry DOI: 10.7270/Q2P84F7M
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM418931
PNG
(US10450301, Example 10)
Show SMILES CC(C)n1nnnc1-c1cccc(NC(=O)c2ccc3CN(Cc3c2)S(=O)(=O)N(C)C)n1
Show InChI InChI=1S/C20H24N8O3S/c1-13(2)28-19(23-24-25-28)17-6-5-7-18(21-17)22-20(29)14-8-9-15-11-27(12-16(15)10-14)32(30,31)26(3)4/h5-10,13H,11-12H2,1-4H3,(H,21,22,29)
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Enanta Pharmaceuticals, Inc.

US Patent


Assay Description
HTRF KinEASE-STK is a generic method for measuring serine/threonine kinase activities using a time-resolved fluorescence resonance energy transfer (T...


US Patent US10450301 (2019)


BindingDB Entry DOI: 10.7270/Q2P84F7M
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM419022
PNG
(US10450301, Example 101)
Show SMILES CCN(C)C(=O)N1CCc2cc(F)c(cc2C1)C(=O)Nc1cccc(n1)-n1nnnc1C(C)C
Show InChI InChI=1S/C23H27FN8O2/c1-5-30(4)23(34)31-10-9-15-12-18(24)17(11-16(15)13-31)22(33)26-19-7-6-8-20(25-19)32-21(14(2)3)27-28-29-32/h6-8,11-12,14H,5,9-10,13H2,1-4H3,(H,25,26,33)
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Enanta Pharmaceuticals, Inc.

US Patent


Assay Description
HTRF KinEASE-STK is a generic method for measuring serine/threonine kinase activities using a time-resolved fluorescence resonance energy transfer (T...


US Patent US10450301 (2019)


BindingDB Entry DOI: 10.7270/Q2P84F7M
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM419005
PNG
(US10450301, Example 84)
Show SMILES C[C@H](COC(C)=O)n1nnnc1-c1cccc(NC(=O)c2cc3CN(CCc3cc2F)S(=O)(=O)CCC(F)(F)F)n1
Show InChI InChI=1S/C24H25F4N7O5S/c1-14(13-40-15(2)36)35-22(31-32-33-35)20-4-3-5-21(29-20)30-23(37)18-10-17-12-34(8-6-16(17)11-19(18)25)41(38,39)9-7-24(26,27)28/h3-5,10-11,14H,6-9,12-13H2,1-2H3,(H,29,30,37)/t14-/m1/s1
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Enanta Pharmaceuticals, Inc.

US Patent


Assay Description
HTRF KinEASE-STK is a generic method for measuring serine/threonine kinase activities using a time-resolved fluorescence resonance energy transfer (T...


US Patent US10450301 (2019)


BindingDB Entry DOI: 10.7270/Q2P84F7M
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM419004
PNG
(US10450301, Example 83)
Show SMILES CC(C)c1nnnn1-c1cccc(NC(=O)c2cc3CN(CCc3cc2F)C(=O)OCc2ccccc2)n1
Show InChI InChI=1S/C27H26FN7O3/c1-17(2)25-31-32-33-35(25)24-10-6-9-23(29-24)30-26(36)21-13-20-15-34(12-11-19(20)14-22(21)28)27(37)38-16-18-7-4-3-5-8-18/h3-10,13-14,17H,11-12,15-16H2,1-2H3,(H,29,30,36)
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Enanta Pharmaceuticals, Inc.

US Patent


Assay Description
HTRF KinEASE-STK is a generic method for measuring serine/threonine kinase activities using a time-resolved fluorescence resonance energy transfer (T...


US Patent US10450301 (2019)


BindingDB Entry DOI: 10.7270/Q2P84F7M
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM419002
PNG
(US10450301, Example 81)
Show SMILES C[C@H](COC(C)=O)n1nnnc1-c1cccc(NC(=O)c2cc3CNCCc3cc2F)n1
Show InChI InChI=1S/C21H22FN7O3/c1-12(11-32-13(2)30)29-20(26-27-28-29)18-4-3-5-19(24-18)25-21(31)16-8-15-10-23-7-6-14(15)9-17(16)22/h3-5,8-9,12,23H,6-7,10-11H2,1-2H3,(H,24,25,31)/t12-/m1/s1
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Enanta Pharmaceuticals, Inc.

US Patent


Assay Description
HTRF KinEASE-STK is a generic method for measuring serine/threonine kinase activities using a time-resolved fluorescence resonance energy transfer (T...


US Patent US10450301 (2019)


BindingDB Entry DOI: 10.7270/Q2P84F7M
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM418992
PNG
(US10450301, Example 71)
Show SMILES CC(C)c1nnnn1-c1cccc(NC(=O)c2cc3CNCCc3cc2F)n1
Show InChI InChI=1S/C19H20FN7O/c1-11(2)18-24-25-26-27(18)17-5-3-4-16(22-17)23-19(28)14-8-13-10-21-7-6-12(13)9-15(14)20/h3-5,8-9,11,21H,6-7,10H2,1-2H3,(H,22,23,28)
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Enanta Pharmaceuticals, Inc.

US Patent


Assay Description
HTRF KinEASE-STK is a generic method for measuring serine/threonine kinase activities using a time-resolved fluorescence resonance energy transfer (T...


US Patent US10450301 (2019)


BindingDB Entry DOI: 10.7270/Q2P84F7M
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%