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Patent code US10456385

Compile Data Set for Download or QSAR
Found 31 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Neuronal acetylcholine receptor protein alpha-7 subunit


(Homo sapiens (Human))
BDBM397124
PNG
(N-(1-azabicyclo[2.2.2]octan-3-yl)-6-oxo-1-(5-propa...)
Show SMILES CC(C)c1cnc(s1)-n1cc(ccc1=O)C(=O)NC1CN2CCC1CC2
Show InChI InChI=1S/C19H24N4O2S/c1-12(2)16-9-20-19(26-16)23-10-14(3-4-17(23)24)18(25)21-15-11-22-7-5-13(15)6-8-22/h3-4,9-10,12-13,15H,5-8,11H2,1-2H3,(H,21,25)
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n/an/an/an/a 300n/an/an/an/a



SK BIOPHARMACEUTICALS CO., LTD.

US Patent


Assay Description
Activity of heteromeric α7 nAChR was measured via FlexStation-Ca2+ influx assay. In the present example, in consideration of α7 nAChR being...


US Patent US10456385 (2019)


BindingDB Entry DOI: 10.7270/Q2V12762
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor protein alpha-7 subunit


(Homo sapiens (Human))
BDBM397132
PNG
(N-(1-azabicyclo[2.2.2]octan-3-yl)-1-(5-phenyl-2-th...)
Show SMILES O=C(NC1CN2CCC1CC2)c1ccc(=O)n(c1)-c1ncc(s1)-c1ccccc1
Show InChI InChI=1S/C22H22N4O2S/c27-20-7-6-17(21(28)24-18-14-25-10-8-15(18)9-11-25)13-26(20)22-23-12-19(29-22)16-4-2-1-3-5-16/h1-7,12-13,15,18H,8-11,14H2,(H,24,28)
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n/an/an/an/a 750n/an/an/an/a



SK BIOPHARMACEUTICALS CO., LTD.

US Patent


Assay Description
Activity of heteromeric α7 nAChR was measured via FlexStation-Ca2+ influx assay. In the present example, in consideration of α7 nAChR being...


US Patent US10456385 (2019)


BindingDB Entry DOI: 10.7270/Q2V12762
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor protein alpha-7 subunit


(Homo sapiens (Human))
BDBM397136
PNG
(N-(1-azabicyclo[2.2.2]octan-3-yl)-6-oxo-1-[5-(phen...)
Show SMILES O=C(NC1CN2CCC1CC2)c1ccc(=O)n(c1)-c1ncc(Cc2ccccc2)s1
Show InChI InChI=1S/C23H24N4O2S/c28-21-7-6-18(22(29)25-20-15-26-10-8-17(20)9-11-26)14-27(21)23-24-13-19(30-23)12-16-4-2-1-3-5-16/h1-7,13-14,17,20H,8-12,15H2,(H,25,29)
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n/an/an/an/a 300n/an/an/an/a



SK BIOPHARMACEUTICALS CO., LTD.

US Patent


Assay Description
Activity of heteromeric α7 nAChR was measured via FlexStation-Ca2+ influx assay. In the present example, in consideration of α7 nAChR being...


US Patent US10456385 (2019)


BindingDB Entry DOI: 10.7270/Q2V12762
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor protein alpha-7 subunit


(Homo sapiens (Human))
BDBM397140
PNG
((1-azabicyclo[2.2.2]octan-3-yl)-1-[5-methyl-1,3-th...)
Show SMILES Cc1cnc(s1)-n1cc(ccc1=O)C(=O)OC1CN2CCC1CC2
Show InChI InChI=1S/C17H19N3O3S/c1-11-8-18-17(24-11)20-9-13(2-3-15(20)21)16(22)23-14-10-19-6-4-12(14)5-7-19/h2-3,8-9,12,14H,4-7,10H2,1H3
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SK BIOPHARMACEUTICALS CO., LTD.

US Patent


Assay Description
Activity of heteromeric α7 nAChR was measured via FlexStation-Ca2+ influx assay. In the present example, in consideration of α7 nAChR being...


US Patent US10456385 (2019)


BindingDB Entry DOI: 10.7270/Q2V12762
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor protein alpha-7 subunit


(Homo sapiens (Human))
BDBM397127
PNG
(N-(1-azabicyclo[2.2.2]octan-3-yl)-1-(5-tert-butyl-...)
Show SMILES CC(C)(C)c1cnc(s1)-n1cc(ccc1=O)C(=O)NC1CN2CCC1CC2
Show InChI InChI=1S/C20H26N4O2S/c1-20(2,3)16-10-21-19(27-16)24-11-14(4-5-17(24)25)18(26)22-15-12-23-8-6-13(15)7-9-23/h4-5,10-11,13,15H,6-9,12H2,1-3H3,(H,22,26)
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SK BIOPHARMACEUTICALS CO., LTD.

US Patent


Assay Description
Activity of heteromeric α7 nAChR was measured via FlexStation-Ca2+ influx assay. In the present example, in consideration of α7 nAChR being...


US Patent US10456385 (2019)


BindingDB Entry DOI: 10.7270/Q2V12762
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor protein alpha-7 subunit


(Homo sapiens (Human))
BDBM397139
PNG
(N-(1-azabicyclo[2.2.2]octan-3-yl)-1-[5-methyl-1,3,...)
Show SMILES Cc1nnc(s1)-n1cc(ccc1=O)C(=O)NC1CN2CCC1CC2
Show InChI InChI=1S/C16H19N5O2S/c1-10-18-19-16(24-10)21-8-12(2-3-14(21)22)15(23)17-13-9-20-6-4-11(13)5-7-20/h2-3,8,11,13H,4-7,9H2,1H3,(H,17,23)
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SK BIOPHARMACEUTICALS CO., LTD.

US Patent


Assay Description
Activity of heteromeric α7 nAChR was measured via FlexStation-Ca2+ influx assay. In the present example, in consideration of α7 nAChR being...


US Patent US10456385 (2019)


BindingDB Entry DOI: 10.7270/Q2V12762
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor protein alpha-7 subunit


(Homo sapiens (Human))
BDBM397120
PNG
(N-(1-azabicyclo[2.2.2]octan-3-yl)-1-(5-ethyl-2-thi...)
Show SMILES CCc1cnc(s1)-n1cc(ccc1=O)C(=O)NC1CN2CCC1CC2
Show InChI InChI=1S/C18H22N4O2S/c1-2-14-9-19-18(25-14)22-10-13(3-4-16(22)23)17(24)20-15-11-21-7-5-12(15)6-8-21/h3-4,9-10,12,15H,2,5-8,11H2,1H3,(H,20,24)
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SK BIOPHARMACEUTICALS CO., LTD.

US Patent


Assay Description
Activity of heteromeric α7 nAChR was measured via FlexStation-Ca2+ influx assay. In the present example, in consideration of α7 nAChR being...


US Patent US10456385 (2019)


BindingDB Entry DOI: 10.7270/Q2V12762
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor protein alpha-7 subunit


(Homo sapiens (Human))
BDBM397112
PNG
(N-[(3R)-1-azabicyclo[2.2.2]octan-3-yl)-6-oxo-1-(2-...)
Show SMILES O=C(N[C@H]1CN2CCC1CC2)c1ccc(=O)n(c1)-c1nccs1
Show InChI InChI=1S/C16H18N4O2S/c21-14-2-1-12(9-20(14)16-17-5-8-23-16)15(22)18-13-10-19-6-3-11(13)4-7-19/h1-2,5,8-9,11,13H,3-4,6-7,10H2,(H,18,22)/t13-/m0/s1
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SK BIOPHARMACEUTICALS CO., LTD.

US Patent


Assay Description
Activity of heteromeric α7 nAChR was measured via FlexStation-Ca2+ influx assay. In the present example, in consideration of α7 nAChR being...


US Patent US10456385 (2019)


BindingDB Entry DOI: 10.7270/Q2V12762
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor protein alpha-7 subunit


(Homo sapiens (Human))
BDBM397114
PNG
(N-(1-azabicyclo[2.2.2]octan-3-yl)-1-(5-chloro-2-py...)
Show SMILES Clc1ccc(nc1)-n1cc(ccc1=O)C(=O)NC1CN2CCC1CC2
Show InChI InChI=1S/C18H19ClN4O2/c19-14-2-3-16(20-9-14)23-10-13(1-4-17(23)24)18(25)21-15-11-22-7-5-12(15)6-8-22/h1-4,9-10,12,15H,5-8,11H2,(H,21,25)
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SK BIOPHARMACEUTICALS CO., LTD.

US Patent


Assay Description
Activity of heteromeric α7 nAChR was measured via FlexStation-Ca2+ influx assay. In the present example, in consideration of α7 nAChR being...


US Patent US10456385 (2019)


BindingDB Entry DOI: 10.7270/Q2V12762
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor protein alpha-7 subunit


(Homo sapiens (Human))
BDBM397119
PNG
(N-[(3S)-1-azabicyclo[2.2.2]octan-3-yl]-1-(5-methyl...)
Show SMILES Cc1cnc(s1)-n1cc(ccc1=O)C(=O)N[C@@H]1CN2CCC1CC2
Show InChI InChI=1S/C17H20N4O2S/c1-11-8-18-17(24-11)21-9-13(2-3-15(21)22)16(23)19-14-10-20-6-4-12(14)5-7-20/h2-3,8-9,12,14H,4-7,10H2,1H3,(H,19,23)/t14-/m1/s1
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n/an/an/an/a 750n/an/an/an/a



SK BIOPHARMACEUTICALS CO., LTD.

US Patent


Assay Description
Activity of heteromeric α7 nAChR was measured via FlexStation-Ca2+ influx assay. In the present example, in consideration of α7 nAChR being...


US Patent US10456385 (2019)


BindingDB Entry DOI: 10.7270/Q2V12762
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor protein alpha-7 subunit


(Homo sapiens (Human))
BDBM397121
PNG
(N-[(3R)-1-azabicyclo[2.2.2]octan-3-yl]-1-(5-ethyl-...)
Show SMILES CCc1cnc(s1)-n1cc(ccc1=O)C(=O)N[C@H]1CN2CCC1CC2
Show InChI InChI=1S/C18H22N4O2S/c1-2-14-9-19-18(25-14)22-10-13(3-4-16(22)23)17(24)20-15-11-21-7-5-12(15)6-8-21/h3-4,9-10,12,15H,2,5-8,11H2,1H3,(H,20,24)/t15-/m0/s1
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n/an/an/an/a<100n/an/an/an/a



SK BIOPHARMACEUTICALS CO., LTD.

US Patent


Assay Description
Activity of heteromeric α7 nAChR was measured via FlexStation-Ca2+ influx assay. In the present example, in consideration of α7 nAChR being...


US Patent US10456385 (2019)


BindingDB Entry DOI: 10.7270/Q2V12762
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor protein alpha-7 subunit


(Homo sapiens (Human))
BDBM397123
PNG
(N-(1-azabicyclo[2.2.2]octan-3-yl)-6-oxo-1-(5-propy...)
Show SMILES CCCc1cnc(s1)-n1cc(ccc1=O)C(=O)NC1CN2CCC1CC2
Show InChI InChI=1S/C19H24N4O2S/c1-2-3-15-10-20-19(26-15)23-11-14(4-5-17(23)24)18(25)21-16-12-22-8-6-13(16)7-9-22/h4-5,10-11,13,16H,2-3,6-9,12H2,1H3,(H,21,25)
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SK BIOPHARMACEUTICALS CO., LTD.

US Patent


Assay Description
Activity of heteromeric α7 nAChR was measured via FlexStation-Ca2+ influx assay. In the present example, in consideration of α7 nAChR being...


US Patent US10456385 (2019)


BindingDB Entry DOI: 10.7270/Q2V12762
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor protein alpha-7 subunit


(Homo sapiens (Human))
BDBM397134
PNG
(N-[(3R)-1-azabicyclo[2.2.2]octan-3-yl]-1-(5-chloro...)
Show SMILES Clc1cnc(s1)-n1cc(ccc1=O)C(=O)N[C@H]1CN2CCC1CC2
Show InChI InChI=1S/C16H17ClN4O2S/c17-13-7-18-16(24-13)21-8-11(1-2-14(21)22)15(23)19-12-9-20-5-3-10(12)4-6-20/h1-2,7-8,10,12H,3-6,9H2,(H,19,23)/t12-/m0/s1
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SK BIOPHARMACEUTICALS CO., LTD.

US Patent


Assay Description
Activity of heteromeric α7 nAChR was measured via FlexStation-Ca2+ influx assay. In the present example, in consideration of α7 nAChR being...


US Patent US10456385 (2019)


BindingDB Entry DOI: 10.7270/Q2V12762
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor protein alpha-7 subunit


(Homo sapiens (Human))
BDBM397135
PNG
(N-[(3S)-1-azabicyclo[2.2.2]octan-3-yl]-1-(5-chloro...)
Show SMILES Clc1cnc(s1)-n1cc(ccc1=O)C(=O)N[C@@H]1CN2CCC1CC2
Show InChI InChI=1S/C16H17ClN4O2S/c17-13-7-18-16(24-13)21-8-11(1-2-14(21)22)15(23)19-12-9-20-5-3-10(12)4-6-20/h1-2,7-8,10,12H,3-6,9H2,(H,19,23)/t12-/m1/s1
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SK BIOPHARMACEUTICALS CO., LTD.

US Patent


Assay Description
Activity of heteromeric α7 nAChR was measured via FlexStation-Ca2+ influx assay. In the present example, in consideration of α7 nAChR being...


US Patent US10456385 (2019)


BindingDB Entry DOI: 10.7270/Q2V12762
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor protein alpha-7 subunit


(Homo sapiens (Human))
BDBM397115
PNG
(N-(1-azabicyclo[2.2.2]octan-3-yl)-6-oxo-1-(5-pheny...)
Show SMILES O=C(NC1CN2CCC1CC2)c1ccc(=O)n(c1)-c1ccc(cn1)-c1ccccc1
Show InChI InChI=1S/C24H24N4O2/c29-23-9-7-20(24(30)26-21-16-27-12-10-18(21)11-13-27)15-28(23)22-8-6-19(14-25-22)17-4-2-1-3-5-17/h1-9,14-15,18,21H,10-13,16H2,(H,26,30)
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SK BIOPHARMACEUTICALS CO., LTD.

US Patent


Assay Description
Activity of heteromeric α7 nAChR was measured via FlexStation-Ca2+ influx assay. In the present example, in consideration of α7 nAChR being...


US Patent US10456385 (2019)


BindingDB Entry DOI: 10.7270/Q2V12762
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor protein alpha-7 subunit


(Homo sapiens (Human))
BDBM397130
PNG
(N-(1-azabicyclo[2.2.2]octan-3-yl)-1-(5-cyclopentyl...)
Show SMILES O=C(NC1CN2CCC1CC2)c1ccc(=O)n(c1)-c1ncc(s1)C1CCCC1
Show InChI InChI=1S/C21H26N4O2S/c26-19-6-5-16(20(27)23-17-13-24-9-7-14(17)8-10-24)12-25(19)21-22-11-18(28-21)15-3-1-2-4-15/h5-6,11-12,14-15,17H,1-4,7-10,13H2,(H,23,27)
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SK BIOPHARMACEUTICALS CO., LTD.

US Patent


Assay Description
Activity of heteromeric α7 nAChR was measured via FlexStation-Ca2+ influx assay. In the present example, in consideration of α7 nAChR being...


US Patent US10456385 (2019)


BindingDB Entry DOI: 10.7270/Q2V12762
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor protein alpha-7 subunit


(Homo sapiens (Human))
BDBM397137
PNG
(N-(1-azabicyclo[2.2.2]octan-3-yl)-1-(4-methyl-2-th...)
Show SMILES Cc1csc(n1)-n1cc(ccc1=O)C(=O)NC1CN2CCC1CC2
Show InChI InChI=1S/C17H20N4O2S/c1-11-10-24-17(18-11)21-8-13(2-3-15(21)22)16(23)19-14-9-20-6-4-12(14)5-7-20/h2-3,8,10,12,14H,4-7,9H2,1H3,(H,19,23)
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SK BIOPHARMACEUTICALS CO., LTD.

US Patent


Assay Description
Activity of heteromeric α7 nAChR was measured via FlexStation-Ca2+ influx assay. In the present example, in consideration of α7 nAChR being...


US Patent US10456385 (2019)


BindingDB Entry DOI: 10.7270/Q2V12762
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor protein alpha-7 subunit


(Homo sapiens (Human))
BDBM397138
PNG
(N-(1-azabicyclo[2.2.2]octan-3-yl)-1-(1,3-benzothia...)
Show SMILES O=C(NC1CN2CCC1CC2)c1ccc(=O)n(c1)-c1nc2ccccc2s1
Show InChI InChI=1S/C20H20N4O2S/c25-18-6-5-14(19(26)21-16-12-23-9-7-13(16)8-10-23)11-24(18)20-22-15-3-1-2-4-17(15)27-20/h1-6,11,13,16H,7-10,12H2,(H,21,26)
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SK BIOPHARMACEUTICALS CO., LTD.

US Patent


Assay Description
Activity of heteromeric α7 nAChR was measured via FlexStation-Ca2+ influx assay. In the present example, in consideration of α7 nAChR being...


US Patent US10456385 (2019)


BindingDB Entry DOI: 10.7270/Q2V12762
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor protein alpha-7 subunit


(Homo sapiens (Human))
BDBM397141
PNG
(US10456385, Example 46 | US9987259, Example 46)
Show SMILES CC(C)c1cnc(s1)-n1cc(ccc1=O)C(=O)OC1CN2CCC1CC2
Show InChI InChI=1S/C19H23N3O3S/c1-12(2)16-9-20-19(26-16)22-10-14(3-4-17(22)23)18(24)25-15-11-21-7-5-13(15)6-8-21/h3-4,9-10,12-13,15H,5-8,11H2,1-2H3
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SK BIOPHARMACEUTICALS CO., LTD.

US Patent


Assay Description
Activity of heteromeric α7 nAChR was measured via FlexStation-Ca2+ influx assay. In the present example, in consideration of α7 nAChR being...


US Patent US10456385 (2019)


BindingDB Entry DOI: 10.7270/Q2V12762
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor protein alpha-7 subunit


(Homo sapiens (Human))
BDBM397117
PNG
(N-(1-azabicyclo[2.2.2]octan-3-yl)-1-(5-methyl-2-th...)
Show SMILES Cc1cnc(s1)-n1cc(ccc1=O)C(=O)NC1CN2CCC1CC2
Show InChI InChI=1S/C17H20N4O2S/c1-11-8-18-17(24-11)21-9-13(2-3-15(21)22)16(23)19-14-10-20-6-4-12(14)5-7-20/h2-3,8-9,12,14H,4-7,10H2,1H3,(H,19,23)
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n/an/an/an/a 300n/an/an/an/a



SK BIOPHARMACEUTICALS CO., LTD.

US Patent


Assay Description
Activity of heteromeric α7 nAChR was measured via FlexStation-Ca2+ influx assay. In the present example, in consideration of α7 nAChR being...


US Patent US10456385 (2019)


BindingDB Entry DOI: 10.7270/Q2V12762
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor protein alpha-7 subunit


(Homo sapiens (Human))
BDBM397126
PNG
(N-[(3S)-1-azabicyclo[2.2.2]octan-3-yl)-6-oxo-1-(5-...)
Show SMILES CC(C)c1cnc(s1)-n1cc(ccc1=O)C(=O)N[C@@H]1CN2CCC1CC2
Show InChI InChI=1S/C19H24N4O2S/c1-12(2)16-9-20-19(26-16)23-10-14(3-4-17(23)24)18(25)21-15-11-22-7-5-13(15)6-8-22/h3-4,9-10,12-13,15H,5-8,11H2,1-2H3,(H,21,25)/t15-/m1/s1
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n/an/an/an/a 300n/an/an/an/a



SK BIOPHARMACEUTICALS CO., LTD.

US Patent


Assay Description
Activity of heteromeric α7 nAChR was measured via FlexStation-Ca2+ influx assay. In the present example, in consideration of α7 nAChR being...


US Patent US10456385 (2019)


BindingDB Entry DOI: 10.7270/Q2V12762
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor protein alpha-7 subunit


(Homo sapiens (Human))
BDBM397116
PNG
(N-(1-azabicyclo[2.2.2]octan-3-yl)-6-oxo-1-[3-pheny...)
Show SMILES O=C(NC1CN2CCC1CC2)c1ccc(=O)n(c1)-c1cc(no1)-c1ccccc1
Show InChI InChI=1S/C22H22N4O3/c27-20-7-6-17(22(28)23-19-14-25-10-8-16(19)9-11-25)13-26(20)21-12-18(24-29-21)15-4-2-1-3-5-15/h1-7,12-13,16,19H,8-11,14H2,(H,23,28)
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SK BIOPHARMACEUTICALS CO., LTD.

US Patent


Assay Description
Activity of heteromeric α7 nAChR was measured via FlexStation-Ca2+ influx assay. In the present example, in consideration of α7 nAChR being...


US Patent US10456385 (2019)


BindingDB Entry DOI: 10.7270/Q2V12762
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor protein alpha-7 subunit


(Homo sapiens (Human))
BDBM397122
PNG
(N-[(3S)-1-azabicyclo[2.2.2]octan-3-yl]-1-(5-ethyl-...)
Show SMILES CCc1cnc(s1)-n1cc(ccc1=O)C(=O)N[C@@H]1CN2CCC1CC2
Show InChI InChI=1S/C18H22N4O2S/c1-2-14-9-19-18(25-14)22-10-13(3-4-16(22)23)17(24)20-15-11-21-7-5-12(15)6-8-21/h3-4,9-10,12,15H,2,5-8,11H2,1H3,(H,20,24)/t15-/m1/s1
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n/an/an/an/a 300n/an/an/an/a



SK BIOPHARMACEUTICALS CO., LTD.

US Patent


Assay Description
Activity of heteromeric α7 nAChR was measured via FlexStation-Ca2+ influx assay. In the present example, in consideration of α7 nAChR being...


US Patent US10456385 (2019)


BindingDB Entry DOI: 10.7270/Q2V12762
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor protein alpha-7 subunit


(Homo sapiens (Human))
BDBM397128
PNG
(N-[(3R)-1-azabicyclo[2.2.2]octan-3-yl]-1-[5-tert-b...)
Show SMILES CC(C)(C)c1cnc(s1)-n1cc(ccc1=O)C(=O)N[C@H]1CN2CCC1CC2
Show InChI InChI=1S/C20H26N4O2S/c1-20(2,3)16-10-21-19(27-16)24-11-14(4-5-17(24)25)18(26)22-15-12-23-8-6-13(15)7-9-23/h4-5,10-11,13,15H,6-9,12H2,1-3H3,(H,22,26)/t15-/m0/s1
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n/an/an/an/a 300n/an/an/an/a



SK BIOPHARMACEUTICALS CO., LTD.

US Patent


Assay Description
Activity of heteromeric α7 nAChR was measured via FlexStation-Ca2+ influx assay. In the present example, in consideration of α7 nAChR being...


US Patent US10456385 (2019)


BindingDB Entry DOI: 10.7270/Q2V12762
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor protein alpha-7 subunit


(Homo sapiens (Human))
BDBM397133
PNG
(N-(1-azabicyclo[2.2.2]octan-3-yl)-1-(5-chloro-2-th...)
Show SMILES Clc1cnc(s1)-n1cc(ccc1=O)C(=O)NC1CN2CCC1CC2
Show InChI InChI=1S/C16H17ClN4O2S/c17-13-7-18-16(24-13)21-8-11(1-2-14(21)22)15(23)19-12-9-20-5-3-10(12)4-6-20/h1-2,7-8,10,12H,3-6,9H2,(H,19,23)
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n/an/an/an/a<100n/an/an/an/a



SK BIOPHARMACEUTICALS CO., LTD.

US Patent


Assay Description
Activity of heteromeric α7 nAChR was measured via FlexStation-Ca2+ influx assay. In the present example, in consideration of α7 nAChR being...


US Patent US10456385 (2019)


BindingDB Entry DOI: 10.7270/Q2V12762
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor protein alpha-7 subunit


(Homo sapiens (Human))
BDBM397111
PNG
(N-(1-azabicyclo[2.2.2]octan-3-yl)-6-oxo-1-(2-thiaz...)
Show SMILES O=C(NC1CN2CCC1CC2)c1ccc(=O)n(c1)-c1nccs1
Show InChI InChI=1S/C16H18N4O2S/c21-14-2-1-12(9-20(14)16-17-5-8-23-16)15(22)18-13-10-19-6-3-11(13)4-7-19/h1-2,5,8-9,11,13H,3-4,6-7,10H2,(H,18,22)
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SK BIOPHARMACEUTICALS CO., LTD.

US Patent


Assay Description
Activity of heteromeric α7 nAChR was measured via FlexStation-Ca2+ influx assay. In the present example, in consideration of α7 nAChR being...


US Patent US10456385 (2019)


BindingDB Entry DOI: 10.7270/Q2V12762
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor protein alpha-7 subunit


(Homo sapiens (Human))
BDBM397113
PNG
(N-[(3S)-1-azabicyclo[2.2.2]octan-3-yl)-6-oxo-1-(2-...)
Show SMILES O=C(N[C@@H]1CN2CCC1CC2)c1ccc(=O)n(c1)-c1nccs1
Show InChI InChI=1S/C16H18N4O2S/c21-14-2-1-12(9-20(14)16-17-5-8-23-16)15(22)18-13-10-19-6-3-11(13)4-7-19/h1-2,5,8-9,11,13H,3-4,6-7,10H2,(H,18,22)/t13-/m1/s1
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SK BIOPHARMACEUTICALS CO., LTD.

US Patent


Assay Description
Activity of heteromeric α7 nAChR was measured via FlexStation-Ca2+ influx assay. In the present example, in consideration of α7 nAChR being...


US Patent US10456385 (2019)


BindingDB Entry DOI: 10.7270/Q2V12762
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor protein alpha-7 subunit


(Homo sapiens (Human))
BDBM397118
PNG
(N-[(3R)-1-azabicyclo[2.2.2]octan-3-yl]-1-(5-methyl...)
Show SMILES Cc1cnc(s1)-n1cc(ccc1=O)C(=O)N[C@H]1CN2CCC1CC2
Show InChI InChI=1S/C17H20N4O2S/c1-11-8-18-17(24-11)21-9-13(2-3-15(21)22)16(23)19-14-10-20-6-4-12(14)5-7-20/h2-3,8-9,12,14H,4-7,10H2,1H3,(H,19,23)/t14-/m0/s1
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SK BIOPHARMACEUTICALS CO., LTD.

US Patent


Assay Description
Activity of heteromeric α7 nAChR was measured via FlexStation-Ca2+ influx assay. In the present example, in consideration of α7 nAChR being...


US Patent US10456385 (2019)


BindingDB Entry DOI: 10.7270/Q2V12762
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor protein alpha-7 subunit


(Homo sapiens (Human))
BDBM397125
PNG
(N-[(3R)-1-azabicyclo[2.2.2]octan-3-yl)-6-oxo-1-(5-...)
Show SMILES CC(C)c1cnc(s1)-n1cc(ccc1=O)C(=O)N[C@H]1CN2CCC1CC2
Show InChI InChI=1S/C19H24N4O2S/c1-12(2)16-9-20-19(26-16)23-10-14(3-4-17(23)24)18(25)21-15-11-22-7-5-13(15)6-8-22/h3-4,9-10,12-13,15H,5-8,11H2,1-2H3,(H,21,25)/t15-/m0/s1
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n/an/an/an/a<100n/an/an/an/a



SK BIOPHARMACEUTICALS CO., LTD.

US Patent


Assay Description
Activity of heteromeric α7 nAChR was measured via FlexStation-Ca2+ influx assay. In the present example, in consideration of α7 nAChR being...


US Patent US10456385 (2019)


BindingDB Entry DOI: 10.7270/Q2V12762
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor protein alpha-7 subunit


(Homo sapiens (Human))
BDBM397131
PNG
(N-(1-azabicyclo[2.2.2]octan-3-yl)-1-(5-cyclohexyl-...)
Show SMILES O=C(NC1CN2CCC1CC2)c1ccc(=O)n(c1)-c1ncc(s1)C1CCCCC1
Show InChI InChI=1S/C22H28N4O2S/c27-20-7-6-17(21(28)24-18-14-25-10-8-15(18)9-11-25)13-26(20)22-23-12-19(29-22)16-4-2-1-3-5-16/h6-7,12-13,15-16,18H,1-5,8-11,14H2,(H,24,28)
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SK BIOPHARMACEUTICALS CO., LTD.

US Patent


Assay Description
Activity of heteromeric α7 nAChR was measured via FlexStation-Ca2+ influx assay. In the present example, in consideration of α7 nAChR being...


US Patent US10456385 (2019)


BindingDB Entry DOI: 10.7270/Q2V12762
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor protein alpha-7 subunit


(Homo sapiens (Human))
BDBM397129
PNG
(N-[(3S)-1-azabicyclo[2.2.2]octan-3-yl]-1-[5-tert-b...)
Show SMILES CC(C)(C)c1cnc(s1)-n1cc(ccc1=O)C(=O)N[C@@H]1CN2CCC1CC2
Show InChI InChI=1S/C20H26N4O2S/c1-20(2,3)16-10-21-19(27-16)24-11-14(4-5-17(24)25)18(26)22-15-12-23-8-6-13(15)7-9-23/h4-5,10-11,13,15H,6-9,12H2,1-3H3,(H,22,26)/t15-/m1/s1
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n/an/an/an/a 750n/an/an/an/a



SK BIOPHARMACEUTICALS CO., LTD.

US Patent


Assay Description
Activity of heteromeric α7 nAChR was measured via FlexStation-Ca2+ influx assay. In the present example, in consideration of α7 nAChR being...


US Patent US10456385 (2019)


BindingDB Entry DOI: 10.7270/Q2V12762
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%