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Patent code US10456394

Compile Data Set for Download or QSAR
Found 62 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Cereblon/Histone deacetylase 6


(Homo sapiens (Human))
BDBM417124
PNG
(US10456394, Example 18 | US10456394, Example 19)
Show SMILES CC(C)(C)OC(=O)N1CC(=O)N(Cc2ccc(cc2)C(=O)NO)c2ccccc12
Show InChI InChI=1S/C21H23N3O5/c1-21(2,3)29-20(27)24-13-18(25)23(16-6-4-5-7-17(16)24)12-14-8-10-15(11-9-14)19(26)22-28/h4-11,28H,12-13H2,1-3H3,(H,22,26)
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n/an/a 1.20n/an/an/an/an/an/a



THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS

US Patent


Assay Description
The effectiveness, or potency, of a present HDACI with respect to inhibiting the activity of an HDAC is measured by an IC50 value. The quantitative I...


US Patent US10456394 (2019)


BindingDB Entry DOI: 10.7270/Q2Q81GFW
More data for this
Ligand-Target Pair
Cereblon/Histone deacetylase 6


(Homo sapiens (Human))
BDBM417122
PNG
(US10456394, Example 17)
Show SMILES ONC(=O)c1ccc(CN2CCS(=O)c3ccccc23)cc1
Show InChI InChI=1S/C16H16N2O3S/c19-16(17-20)13-7-5-12(6-8-13)11-18-9-10-22(21)15-4-2-1-3-14(15)18/h1-8,20H,9-11H2,(H,17,19)
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n/an/a 2n/an/an/an/an/an/a



THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS

US Patent


Assay Description
The effectiveness, or potency, of a present HDACI with respect to inhibiting the activity of an HDAC is measured by an IC50 value. The quantitative I...


US Patent US10456394 (2019)


BindingDB Entry DOI: 10.7270/Q2Q81GFW
More data for this
Ligand-Target Pair
Cereblon/Histone deacetylase 6


(Homo sapiens (Human))
BDBM417119
PNG
(US10456394, Example 14 | US10456394, Example 15)
Show SMILES COC(=O)c1ccc(CN2CCN(C(=O)OC(C)(C)C)c3ccccc23)cc1
Show InChI InChI=1S/C22H26N2O4/c1-22(2,3)28-21(26)24-14-13-23(18-7-5-6-8-19(18)24)15-16-9-11-17(12-10-16)20(25)27-4/h5-12H,13-15H2,1-4H3
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n/an/a 2.90n/an/an/an/an/an/a



THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS

US Patent


Assay Description
The effectiveness, or potency, of a present HDACI with respect to inhibiting the activity of an HDAC is measured by an IC50 value. The quantitative I...


US Patent US10456394 (2019)


BindingDB Entry DOI: 10.7270/Q2Q81GFW
More data for this
Ligand-Target Pair
Cereblon/Histone deacetylase 6


(Homo sapiens (Human))
BDBM417049
PNG
(4-((6-chloro-3,4-dihydroquinolin-1(2H)-yl)methyl)-...)
Show SMILES ONC(=O)c1ccc(CN2CCCc3cc(Cl)ccc23)cc1
Show InChI InChI=1S/C17H17ClN2O2/c18-15-7-8-16-14(10-15)2-1-9-20(16)11-12-3-5-13(6-4-12)17(21)19-22/h3-8,10,22H,1-2,9,11H2,(H,19,21)
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n/an/a 2.90n/an/an/an/an/an/a



THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS

US Patent


Assay Description
The effectiveness, or potency, of a present HDACI with respect to inhibiting the activity of an HDAC is measured by an IC50 value. The quantitative I...


US Patent US10456394 (2019)


BindingDB Entry DOI: 10.7270/Q2Q81GFW
More data for this
Ligand-Target Pair
Cereblon/Histone deacetylase 6


(Homo sapiens (Human))
BDBM417049
PNG
(4-((6-chloro-3,4-dihydroquinolin-1(2H)-yl)methyl)-...)
Show SMILES ONC(=O)c1ccc(CN2CCCc3cc(Cl)ccc23)cc1
Show InChI InChI=1S/C17H17ClN2O2/c18-15-7-8-16-14(10-15)2-1-9-20(16)11-12-3-5-13(6-4-12)17(21)19-22/h3-8,10,22H,1-2,9,11H2,(H,19,21)
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n/an/a 2.91n/an/an/an/an/an/a



THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS

US Patent


Assay Description
The effectiveness, or potency, of a present HDACI with respect to inhibiting the activity of an HDAC is measured by an IC50 value. The quantitative I...


US Patent US10456394 (2019)


BindingDB Entry DOI: 10.7270/Q2Q81GFW
More data for this
Ligand-Target Pair
Cereblon/Histone deacetylase 6


(Homo sapiens (Human))
BDBM417070
PNG
(US10456394, Example 7)
Show SMILES ONC(=O)c1ccc(CN2CCCc3cc(F)c(Cl)cc23)cc1
Show InChI InChI=1S/C17H16ClFN2O2/c18-14-9-16-13(8-15(14)19)2-1-7-21(16)10-11-3-5-12(6-4-11)17(22)20-23/h3-6,8-9,23H,1-2,7,10H2,(H,20,22)
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n/an/a 3.43n/an/an/an/an/an/a



THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS

US Patent


Assay Description
The effectiveness, or potency, of a present HDACI with respect to inhibiting the activity of an HDAC is measured by an IC50 value. The quantitative I...


US Patent US10456394 (2019)


BindingDB Entry DOI: 10.7270/Q2Q81GFW
More data for this
Ligand-Target Pair
Cereblon/Histone deacetylase 6


(Homo sapiens (Human))
BDBM417068
PNG
(US10456394, Example 6)
Show SMILES ONC(=O)c1ccc(CN2CCCc3cc(Cl)c(Cl)cc23)cc1
Show InChI InChI=1S/C17H16Cl2N2O2/c18-14-8-13-2-1-7-21(16(13)9-15(14)19)10-11-3-5-12(6-4-11)17(22)20-23/h3-6,8-9,23H,1-2,7,10H2,(H,20,22)
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n/an/a 3.59n/an/an/an/an/an/a



THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS

US Patent


Assay Description
The effectiveness, or potency, of a present HDACI with respect to inhibiting the activity of an HDAC is measured by an IC50 value. The quantitative I...


US Patent US10456394 (2019)


BindingDB Entry DOI: 10.7270/Q2Q81GFW
More data for this
Ligand-Target Pair
Cereblon/Histone deacetylase 6


(Homo sapiens (Human))
BDBM417072
PNG
(US10456394, Example 8)
Show SMILES ONC(=O)c1ccc(CN2CCCc3cc(Cl)c(F)cc23)cc1
Show InChI InChI=1S/C17H16ClFN2O2/c18-14-8-13-2-1-7-21(16(13)9-15(14)19)10-11-3-5-12(6-4-11)17(22)20-23/h3-6,8-9,23H,1-2,7,10H2,(H,20,22)
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n/an/a 4.80n/an/an/an/an/an/a



THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS

US Patent


Assay Description
The effectiveness, or potency, of a present HDACI with respect to inhibiting the activity of an HDAC is measured by an IC50 value. The quantitative I...


US Patent US10456394 (2019)


BindingDB Entry DOI: 10.7270/Q2Q81GFW
More data for this
Ligand-Target Pair
Cereblon/Histone deacetylase 6


(Homo sapiens (Human))
BDBM417067
PNG
(US10456394, Example 5)
Show SMILES ONC(=O)c1ccc(CN2CCCc3cc(F)ccc23)cc1
Show InChI InChI=1S/C17H17FN2O2/c18-15-7-8-16-14(10-15)2-1-9-20(16)11-12-3-5-13(6-4-12)17(21)19-22/h3-8,10,22H,1-2,9,11H2,(H,19,21)
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n/an/a 5.05n/an/an/an/an/an/a



THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS

US Patent


Assay Description
The effectiveness, or potency, of a present HDACI with respect to inhibiting the activity of an HDAC is measured by an IC50 value. The quantitative I...


US Patent US10456394 (2019)


BindingDB Entry DOI: 10.7270/Q2Q81GFW
More data for this
Ligand-Target Pair
Cereblon/Histone deacetylase 6


(Homo sapiens (Human))
BDBM50380399
PNG
(CHEMBL2018302 | Tubastatin A | US10227295, Compoun...)
Show SMILES CN1CCc2c(C1)c1ccccc1n2Cc1ccc(cc1)C(=O)NO
Show InChI InChI=1S/C20H21N3O2/c1-22-11-10-19-17(13-22)16-4-2-3-5-18(16)23(19)12-14-6-8-15(9-7-14)20(24)21-25/h2-9,25H,10-13H2,1H3,(H,21,24)
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n/an/a 6n/an/an/an/an/an/a



THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS

US Patent


Assay Description
The effectiveness, or potency, of a present HDACI with respect to inhibiting the activity of an HDAC is measured by an IC50 value. The quantitative I...


US Patent US10456394 (2019)


BindingDB Entry DOI: 10.7270/Q2Q81GFW
More data for this
Ligand-Target Pair
Cereblon/Histone deacetylase 6


(Homo sapiens (Human))
BDBM417121
PNG
(US10456394, Example 16)
Show SMILES ONC(=O)c1ccc(CN2CCSc3ccccc23)cc1
Show InChI InChI=1S/C16H16N2O2S/c19-16(17-20)13-7-5-12(6-8-13)11-18-9-10-21-15-4-2-1-3-14(15)18/h1-8,20H,9-11H2,(H,17,19)
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n/an/a 6.10n/an/an/an/an/an/a



THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS

US Patent


Assay Description
The effectiveness, or potency, of a present HDACI with respect to inhibiting the activity of an HDAC is measured by an IC50 value. The quantitative I...


US Patent US10456394 (2019)


BindingDB Entry DOI: 10.7270/Q2Q81GFW
More data for this
Ligand-Target Pair
Cereblon/Histone deacetylase 6


(Homo sapiens (Human))
BDBM417065
PNG
(4-((6-chloro-3,4-dihydroquinolin-1(2H)-yl)methyl)-...)
Show SMILES ONC(=O)c1ccc(CN2CCCc3cc(Cl)ccc23)c(F)c1
Show InChI InChI=1S/C17H16ClFN2O2/c18-14-5-6-16-11(8-14)2-1-7-21(16)10-13-4-3-12(9-15(13)19)17(22)20-23/h3-6,8-9,23H,1-2,7,10H2,(H,20,22)
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n/an/a 12.4n/an/an/an/an/an/a



THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS

US Patent


Assay Description
The effectiveness, or potency, of a present HDACI with respect to inhibiting the activity of an HDAC is measured by an IC50 value. The quantitative I...


US Patent US10456394 (2019)


BindingDB Entry DOI: 10.7270/Q2Q81GFW
More data for this
Ligand-Target Pair
Cereblon/Histone deacetylase 6


(Homo sapiens (Human))
BDBM417063
PNG
(4-((3,4-dihydroquinolin-1(2H)-yl)methyl)-N-hydroxy...)
Show SMILES ONC(=O)c1ccc(CN2CCCc3ccccc23)cc1
Show InChI InChI=1S/C17H18N2O2/c20-17(18-21)15-9-7-13(8-10-15)12-19-11-3-5-14-4-1-2-6-16(14)19/h1-2,4,6-10,21H,3,5,11-12H2,(H,18,20)
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n/an/a 14.6n/an/an/an/an/an/a



THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS

US Patent


Assay Description
The effectiveness, or potency, of a present HDACI with respect to inhibiting the activity of an HDAC is measured by an IC50 value. The quantitative I...


US Patent US10456394 (2019)


BindingDB Entry DOI: 10.7270/Q2Q81GFW
More data for this
Ligand-Target Pair
Cereblon/Histone deacetylase 6


(Homo sapiens (Human))
BDBM50380399
PNG
(CHEMBL2018302 | Tubastatin A | US10227295, Compoun...)
Show SMILES CN1CCc2c(C1)c1ccccc1n2Cc1ccc(cc1)C(=O)NO
Show InChI InChI=1S/C20H21N3O2/c1-22-11-10-19-17(13-22)16-4-2-3-5-18(16)23(19)12-14-6-8-15(9-7-14)20(24)21-25/h2-9,25H,10-13H2,1H3,(H,21,24)
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n/an/a 15n/an/an/an/an/an/a



THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS

US Patent


Assay Description
The effectiveness, or potency, of a present HDACI with respect to inhibiting the activity of an HDAC is measured by an IC50 value. The quantitative I...


US Patent US10456394 (2019)


BindingDB Entry DOI: 10.7270/Q2Q81GFW
More data for this
Ligand-Target Pair
Cereblon/Histone deacetylase 6


(Homo sapiens (Human))
BDBM417116
PNG
(US10456394, Example 11)
Show SMILES CC1(C)CC(=O)N(Cc2ccc(cc2)C(=O)NO)c2ccc(Cl)cc12
Show InChI InChI=1S/C19H19ClN2O3/c1-19(2)10-17(23)22(16-8-7-14(20)9-15(16)19)11-12-3-5-13(6-4-12)18(24)21-25/h3-9,25H,10-11H2,1-2H3,(H,21,24)
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n/an/a 28.9n/an/an/an/an/an/a



THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS

US Patent


Assay Description
The effectiveness, or potency, of a present HDACI with respect to inhibiting the activity of an HDAC is measured by an IC50 value. The quantitative I...


US Patent US10456394 (2019)


BindingDB Entry DOI: 10.7270/Q2Q81GFW
More data for this
Ligand-Target Pair
Cereblon/Histone deacetylase 6


(Homo sapiens (Human))
BDBM417124
PNG
(US10456394, Example 18 | US10456394, Example 19)
Show SMILES CC(C)(C)OC(=O)N1CC(=O)N(Cc2ccc(cc2)C(=O)NO)c2ccccc12
Show InChI InChI=1S/C21H23N3O5/c1-21(2,3)29-20(27)24-13-18(25)23(16-6-4-5-7-17(16)24)12-14-8-10-15(11-9-14)19(26)22-28/h4-11,28H,12-13H2,1-3H3,(H,22,26)
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n/an/a 33.6n/an/an/an/an/an/a



THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS

US Patent


Assay Description
The effectiveness, or potency, of a present HDACI with respect to inhibiting the activity of an HDAC is measured by an IC50 value. The quantitative I...


US Patent US10456394 (2019)


BindingDB Entry DOI: 10.7270/Q2Q81GFW
More data for this
Ligand-Target Pair
Cereblon/Histone deacetylase 6


(Homo sapiens (Human))
BDBM417117
PNG
(US10456394, Example 12)
Show SMILES CC1(C)CCN(Cc2ccc(cc2)C(=O)NO)c2ccc(Cl)cc12
Show InChI InChI=1S/C19H21ClN2O2/c1-19(2)9-10-22(17-8-7-15(20)11-16(17)19)12-13-3-5-14(6-4-13)18(23)21-24/h3-8,11,24H,9-10,12H2,1-2H3,(H,21,23)
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n/an/a 37.8n/an/an/an/an/an/a



THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS

US Patent


Assay Description
The effectiveness, or potency, of a present HDACI with respect to inhibiting the activity of an HDAC is measured by an IC50 value. The quantitative I...


US Patent US10456394 (2019)


BindingDB Entry DOI: 10.7270/Q2Q81GFW
More data for this
Ligand-Target Pair
Cereblon/Histone deacetylase 6


(Homo sapiens (Human))
BDBM417119
PNG
(US10456394, Example 14 | US10456394, Example 15)
Show SMILES COC(=O)c1ccc(CN2CCN(C(=O)OC(C)(C)C)c3ccccc23)cc1
Show InChI InChI=1S/C22H26N2O4/c1-22(2,3)28-21(26)24-14-13-23(18-7-5-6-8-19(18)24)15-16-9-11-17(12-10-16)20(25)27-4/h5-12H,13-15H2,1-4H3
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n/an/a 39.3n/an/an/an/an/an/a



THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS

US Patent


Assay Description
The effectiveness, or potency, of a present HDACI with respect to inhibiting the activity of an HDAC is measured by an IC50 value. The quantitative I...


US Patent US10456394 (2019)


BindingDB Entry DOI: 10.7270/Q2Q81GFW
More data for this
Ligand-Target Pair
Cereblon/Histone deacetylase 6


(Homo sapiens (Human))
BDBM417118
PNG
(US10456394, Example 13)
Show SMILES CC1(C)CCN(Cc2ccc(cc2)C(=O)NO)c2ccc(F)cc12
Show InChI InChI=1S/C19H21FN2O2/c1-19(2)9-10-22(17-8-7-15(20)11-16(17)19)12-13-3-5-14(6-4-13)18(23)21-24/h3-8,11,24H,9-10,12H2,1-2H3,(H,21,23)
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n/an/a 45.1n/an/an/an/an/an/a



THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS

US Patent


Assay Description
The effectiveness, or potency, of a present HDACI with respect to inhibiting the activity of an HDAC is measured by an IC50 value. The quantitative I...


US Patent US10456394 (2019)


BindingDB Entry DOI: 10.7270/Q2Q81GFW
More data for this
Ligand-Target Pair
Cereblon/Histone deacetylase 6


(Homo sapiens (Human))
BDBM417100
PNG
(US10456394, Example 10)
Show SMILES CC1(C)CCc2cc(F)ccc2N1Cc1ccc(cc1)C(=O)NO
Show InChI InChI=1S/C19H21FN2O2/c1-19(2)10-9-15-11-16(20)7-8-17(15)22(19)12-13-3-5-14(6-4-13)18(23)21-24/h3-8,11,24H,9-10,12H2,1-2H3,(H,21,23)
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n/an/a 161n/an/an/an/an/an/a



THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS

US Patent


Assay Description
The effectiveness, or potency, of a present HDACI with respect to inhibiting the activity of an HDAC is measured by an IC50 value. The quantitative I...


US Patent US10456394 (2019)


BindingDB Entry DOI: 10.7270/Q2Q81GFW
More data for this
Ligand-Target Pair
Cereblon/Histone deacetylase 6


(Homo sapiens (Human))
BDBM417080
PNG
(US10456394, Example 9)
Show SMILES CC1(C)CCc2cc(Cl)ccc2N1Cc1ccc(cc1)C(=O)NO
Show InChI InChI=1S/C19H21ClN2O2/c1-19(2)10-9-15-11-16(20)7-8-17(15)22(19)12-13-3-5-14(6-4-13)18(23)21-24/h3-8,11,24H,9-10,12H2,1-2H3,(H,21,23)
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n/an/a 328n/an/an/an/an/an/a



THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS

US Patent


Assay Description
The effectiveness, or potency, of a present HDACI with respect to inhibiting the activity of an HDAC is measured by an IC50 value. The quantitative I...


US Patent US10456394 (2019)


BindingDB Entry DOI: 10.7270/Q2Q81GFW
More data for this
Ligand-Target Pair
Histone deacetylase 7


(Homo sapiens (Human))
BDBM50380399
PNG
(CHEMBL2018302 | Tubastatin A | US10227295, Compoun...)
Show SMILES CN1CCc2c(C1)c1ccccc1n2Cc1ccc(cc1)C(=O)NO
Show InChI InChI=1S/C20H21N3O2/c1-22-11-10-19-17(13-22)16-4-2-3-5-18(16)23(19)12-14-6-8-15(9-7-14)20(24)21-25/h2-9,25H,10-13H2,1H3,(H,21,24)
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n/an/a 377n/an/an/an/an/an/a



THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS

US Patent


Assay Description
The effectiveness, or potency, of a present HDACI with respect to inhibiting the activity of an HDAC is measured by an IC50 value. The quantitative I...


US Patent US10456394 (2019)


BindingDB Entry DOI: 10.7270/Q2Q81GFW
More data for this
Ligand-Target Pair
Cereblon/Histone deacetylase 6


(Homo sapiens (Human))
BDBM417066
PNG
(US10456394, Example 4)
Show SMILES CC(N1CCCc2cc(Cl)ccc12)c1ccc(cc1)C(=O)NO
Show InChI InChI=1S/C18H19ClN2O2/c1-12(13-4-6-14(7-5-13)18(22)20-23)21-10-2-3-15-11-16(19)8-9-17(15)21/h4-9,11-12,23H,2-3,10H2,1H3,(H,20,22)
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n/an/a 382n/an/an/an/an/an/a



THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS

US Patent


Assay Description
The effectiveness, or potency, of a present HDACI with respect to inhibiting the activity of an HDAC is measured by an IC50 value. The quantitative I...


US Patent US10456394 (2019)


BindingDB Entry DOI: 10.7270/Q2Q81GFW
More data for this
Ligand-Target Pair
Histone deacetylase 11


(Homo sapiens (Human))
BDBM417049
PNG
(4-((6-chloro-3,4-dihydroquinolin-1(2H)-yl)methyl)-...)
Show SMILES ONC(=O)c1ccc(CN2CCCc3cc(Cl)ccc23)cc1
Show InChI InChI=1S/C17H17ClN2O2/c18-15-7-8-16-14(10-15)2-1-9-20(16)11-12-3-5-13(6-4-12)17(21)19-22/h3-8,10,22H,1-2,9,11H2,(H,19,21)
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n/an/a 746n/an/an/an/an/an/a



THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS

US Patent


Assay Description
The effectiveness, or potency, of a present HDACI with respect to inhibiting the activity of an HDAC is measured by an IC50 value. The quantitative I...


US Patent US10456394 (2019)


BindingDB Entry DOI: 10.7270/Q2Q81GFW
More data for this
Ligand-Target Pair
Histone deacetylase 9


(Homo sapiens (Human))
BDBM50380399
PNG
(CHEMBL2018302 | Tubastatin A | US10227295, Compoun...)
Show SMILES CN1CCc2c(C1)c1ccccc1n2Cc1ccc(cc1)C(=O)NO
Show InChI InChI=1S/C20H21N3O2/c1-22-11-10-19-17(13-22)16-4-2-3-5-18(16)23(19)12-14-6-8-15(9-7-14)20(24)21-25/h2-9,25H,10-13H2,1H3,(H,21,24)
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n/an/a 950n/an/an/an/an/an/a



THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS

US Patent


Assay Description
The effectiveness, or potency, of a present HDACI with respect to inhibiting the activity of an HDAC is measured by an IC50 value. The quantitative I...


US Patent US10456394 (2019)


BindingDB Entry DOI: 10.7270/Q2Q81GFW
More data for this
Ligand-Target Pair
Histone deacetylase 8


(Homo sapiens (Human))
BDBM50380399
PNG
(CHEMBL2018302 | Tubastatin A | US10227295, Compoun...)
Show SMILES CN1CCc2c(C1)c1ccccc1n2Cc1ccc(cc1)C(=O)NO
Show InChI InChI=1S/C20H21N3O2/c1-22-11-10-19-17(13-22)16-4-2-3-5-18(16)23(19)12-14-6-8-15(9-7-14)20(24)21-25/h2-9,25H,10-13H2,1H3,(H,21,24)
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n/an/a 1.01E+3n/an/an/an/an/an/a



THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS

US Patent


Assay Description
The effectiveness, or potency, of a present HDACI with respect to inhibiting the activity of an HDAC is measured by an IC50 value. The quantitative I...


US Patent US10456394 (2019)


BindingDB Entry DOI: 10.7270/Q2Q81GFW
More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))
BDBM417124
PNG
(US10456394, Example 18 | US10456394, Example 19)
Show SMILES CC(C)(C)OC(=O)N1CC(=O)N(Cc2ccc(cc2)C(=O)NO)c2ccccc12
Show InChI InChI=1S/C21H23N3O5/c1-21(2,3)29-20(27)24-13-18(25)23(16-6-4-5-7-17(16)24)12-14-8-10-15(11-9-14)19(26)22-28/h4-11,28H,12-13H2,1-3H3,(H,22,26)
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n/an/a 1.05E+3n/an/an/an/an/an/a



THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS

US Patent


Assay Description
The effectiveness, or potency, of a present HDACI with respect to inhibiting the activity of an HDAC is measured by an IC50 value. The quantitative I...


US Patent US10456394 (2019)


BindingDB Entry DOI: 10.7270/Q2Q81GFW
More data for this
Ligand-Target Pair
Histone deacetylase 5


(Homo sapiens (Human))
BDBM50380399
PNG
(CHEMBL2018302 | Tubastatin A | US10227295, Compoun...)
Show SMILES CN1CCc2c(C1)c1ccccc1n2Cc1ccc(cc1)C(=O)NO
Show InChI InChI=1S/C20H21N3O2/c1-22-11-10-19-17(13-22)16-4-2-3-5-18(16)23(19)12-14-6-8-15(9-7-14)20(24)21-25/h2-9,25H,10-13H2,1H3,(H,21,24)
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n/an/a 1.45E+3n/an/an/an/an/an/a



THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS

US Patent


Assay Description
The effectiveness, or potency, of a present HDACI with respect to inhibiting the activity of an HDAC is measured by an IC50 value. The quantitative I...


US Patent US10456394 (2019)


BindingDB Entry DOI: 10.7270/Q2Q81GFW
More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))
BDBM417070
PNG
(US10456394, Example 7)
Show SMILES ONC(=O)c1ccc(CN2CCCc3cc(F)c(Cl)cc23)cc1
Show InChI InChI=1S/C17H16ClFN2O2/c18-14-9-16-13(8-15(14)19)2-1-7-21(16)10-11-3-5-12(6-4-11)17(22)20-23/h3-6,8-9,23H,1-2,7,10H2,(H,20,22)
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n/an/a 1.87E+3n/an/an/an/an/an/a



THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS

US Patent


Assay Description
The effectiveness, or potency, of a present HDACI with respect to inhibiting the activity of an HDAC is measured by an IC50 value. The quantitative I...


US Patent US10456394 (2019)


BindingDB Entry DOI: 10.7270/Q2Q81GFW
More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))
BDBM417122
PNG
(US10456394, Example 17)
Show SMILES ONC(=O)c1ccc(CN2CCS(=O)c3ccccc23)cc1
Show InChI InChI=1S/C16H16N2O3S/c19-16(17-20)13-7-5-12(6-8-13)11-18-9-10-22(21)15-4-2-1-3-14(15)18/h1-8,20H,9-11H2,(H,17,19)
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n/an/a 2.60E+3n/an/an/an/an/an/a



THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS

US Patent


Assay Description
The effectiveness, or potency, of a present HDACI with respect to inhibiting the activity of an HDAC is measured by an IC50 value. The quantitative I...


US Patent US10456394 (2019)


BindingDB Entry DOI: 10.7270/Q2Q81GFW
More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))
BDBM417068
PNG
(US10456394, Example 6)
Show SMILES ONC(=O)c1ccc(CN2CCCc3cc(Cl)c(Cl)cc23)cc1
Show InChI InChI=1S/C17H16Cl2N2O2/c18-14-8-13-2-1-7-21(16(13)9-15(14)19)10-11-3-5-12(6-4-11)17(22)20-23/h3-6,8-9,23H,1-2,7,10H2,(H,20,22)
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n/an/a 2.62E+3n/an/an/an/an/an/a



THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS

US Patent


Assay Description
The effectiveness, or potency, of a present HDACI with respect to inhibiting the activity of an HDAC is measured by an IC50 value. The quantitative I...


US Patent US10456394 (2019)


BindingDB Entry DOI: 10.7270/Q2Q81GFW
More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))
BDBM417072
PNG
(US10456394, Example 8)
Show SMILES ONC(=O)c1ccc(CN2CCCc3cc(Cl)c(F)cc23)cc1
Show InChI InChI=1S/C17H16ClFN2O2/c18-14-8-13-2-1-7-21(16(13)9-15(14)19)10-11-3-5-12(6-4-11)17(22)20-23/h3-6,8-9,23H,1-2,7,10H2,(H,20,22)
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n/an/a 3.22E+3n/an/an/an/an/an/a



THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS

US Patent


Assay Description
The effectiveness, or potency, of a present HDACI with respect to inhibiting the activity of an HDAC is measured by an IC50 value. The quantitative I...


US Patent US10456394 (2019)


BindingDB Entry DOI: 10.7270/Q2Q81GFW
More data for this
Ligand-Target Pair
Histone deacetylase 8


(Homo sapiens (Human))
BDBM417049
PNG
(4-((6-chloro-3,4-dihydroquinolin-1(2H)-yl)methyl)-...)
Show SMILES ONC(=O)c1ccc(CN2CCCc3cc(Cl)ccc23)cc1
Show InChI InChI=1S/C17H17ClN2O2/c18-15-7-8-16-14(10-15)2-1-9-20(16)11-12-3-5-13(6-4-12)17(21)19-22/h3-8,10,22H,1-2,9,11H2,(H,19,21)
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n/an/a 3.34E+3n/an/an/an/an/an/a



THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS

US Patent


Assay Description
The effectiveness, or potency, of a present HDACI with respect to inhibiting the activity of an HDAC is measured by an IC50 value. The quantitative I...


US Patent US10456394 (2019)


BindingDB Entry DOI: 10.7270/Q2Q81GFW
More data for this
Ligand-Target Pair
Histone deacetylase 9


(Homo sapiens (Human))
BDBM417049
PNG
(4-((6-chloro-3,4-dihydroquinolin-1(2H)-yl)methyl)-...)
Show SMILES ONC(=O)c1ccc(CN2CCCc3cc(Cl)ccc23)cc1
Show InChI InChI=1S/C17H17ClN2O2/c18-15-7-8-16-14(10-15)2-1-9-20(16)11-12-3-5-13(6-4-12)17(21)19-22/h3-8,10,22H,1-2,9,11H2,(H,19,21)
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n/an/a 3.46E+3n/an/an/an/an/an/a



THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS

US Patent


Assay Description
The effectiveness, or potency, of a present HDACI with respect to inhibiting the activity of an HDAC is measured by an IC50 value. The quantitative I...


US Patent US10456394 (2019)


BindingDB Entry DOI: 10.7270/Q2Q81GFW
More data for this
Ligand-Target Pair
Histone deacetylase 4


(Homo sapiens (Human))
BDBM50380399
PNG
(CHEMBL2018302 | Tubastatin A | US10227295, Compoun...)
Show SMILES CN1CCc2c(C1)c1ccccc1n2Cc1ccc(cc1)C(=O)NO
Show InChI InChI=1S/C20H21N3O2/c1-22-11-10-19-17(13-22)16-4-2-3-5-18(16)23(19)12-14-6-8-15(9-7-14)20(24)21-25/h2-9,25H,10-13H2,1H3,(H,21,24)
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n/an/a 3.67E+3n/an/an/an/an/an/a



THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS

US Patent


Assay Description
The effectiveness, or potency, of a present HDACI with respect to inhibiting the activity of an HDAC is measured by an IC50 value. The quantitative I...


US Patent US10456394 (2019)


BindingDB Entry DOI: 10.7270/Q2Q81GFW
More data for this
Ligand-Target Pair
Histone deacetylase 7


(Homo sapiens (Human))
BDBM417049
PNG
(4-((6-chloro-3,4-dihydroquinolin-1(2H)-yl)methyl)-...)
Show SMILES ONC(=O)c1ccc(CN2CCCc3cc(Cl)ccc23)cc1
Show InChI InChI=1S/C17H17ClN2O2/c18-15-7-8-16-14(10-15)2-1-9-20(16)11-12-3-5-13(6-4-12)17(21)19-22/h3-8,10,22H,1-2,9,11H2,(H,19,21)
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n/an/a 4.07E+3n/an/an/an/an/an/a



THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS

US Patent


Assay Description
The effectiveness, or potency, of a present HDACI with respect to inhibiting the activity of an HDAC is measured by an IC50 value. The quantitative I...


US Patent US10456394 (2019)


BindingDB Entry DOI: 10.7270/Q2Q81GFW
More data for this
Ligand-Target Pair
Histone deacetylase 5


(Homo sapiens (Human))
BDBM417049
PNG
(4-((6-chloro-3,4-dihydroquinolin-1(2H)-yl)methyl)-...)
Show SMILES ONC(=O)c1ccc(CN2CCCc3cc(Cl)ccc23)cc1
Show InChI InChI=1S/C17H17ClN2O2/c18-15-7-8-16-14(10-15)2-1-9-20(16)11-12-3-5-13(6-4-12)17(21)19-22/h3-8,10,22H,1-2,9,11H2,(H,19,21)
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n/an/a 4.55E+3n/an/an/an/an/an/a



THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS

US Patent


Assay Description
The effectiveness, or potency, of a present HDACI with respect to inhibiting the activity of an HDAC is measured by an IC50 value. The quantitative I...


US Patent US10456394 (2019)


BindingDB Entry DOI: 10.7270/Q2Q81GFW
More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))
BDBM417049
PNG
(4-((6-chloro-3,4-dihydroquinolin-1(2H)-yl)methyl)-...)
Show SMILES ONC(=O)c1ccc(CN2CCCc3cc(Cl)ccc23)cc1
Show InChI InChI=1S/C17H17ClN2O2/c18-15-7-8-16-14(10-15)2-1-9-20(16)11-12-3-5-13(6-4-12)17(21)19-22/h3-8,10,22H,1-2,9,11H2,(H,19,21)
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n/an/a 5.22E+3n/an/an/an/an/an/a



THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS

US Patent


Assay Description
The effectiveness, or potency, of a present HDACI with respect to inhibiting the activity of an HDAC is measured by an IC50 value. The quantitative I...


US Patent US10456394 (2019)


BindingDB Entry DOI: 10.7270/Q2Q81GFW
More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))
BDBM417049
PNG
(4-((6-chloro-3,4-dihydroquinolin-1(2H)-yl)methyl)-...)
Show SMILES ONC(=O)c1ccc(CN2CCCc3cc(Cl)ccc23)cc1
Show InChI InChI=1S/C17H17ClN2O2/c18-15-7-8-16-14(10-15)2-1-9-20(16)11-12-3-5-13(6-4-12)17(21)19-22/h3-8,10,22H,1-2,9,11H2,(H,19,21)
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n/an/a 5.22E+3n/an/an/an/an/an/a



THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS

US Patent


Assay Description
The effectiveness, or potency, of a present HDACI with respect to inhibiting the activity of an HDAC is measured by an IC50 value. The quantitative I...


US Patent US10456394 (2019)


BindingDB Entry DOI: 10.7270/Q2Q81GFW
More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))
BDBM417067
PNG
(US10456394, Example 5)
Show SMILES ONC(=O)c1ccc(CN2CCCc3cc(F)ccc23)cc1
Show InChI InChI=1S/C17H17FN2O2/c18-15-7-8-16-14(10-15)2-1-9-20(16)11-12-3-5-13(6-4-12)17(21)19-22/h3-8,10,22H,1-2,9,11H2,(H,19,21)
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n/an/a 5.24E+3n/an/an/an/an/an/a



THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS

US Patent


Assay Description
The effectiveness, or potency, of a present HDACI with respect to inhibiting the activity of an HDAC is measured by an IC50 value. The quantitative I...


US Patent US10456394 (2019)


BindingDB Entry DOI: 10.7270/Q2Q81GFW
More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))
BDBM417116
PNG
(US10456394, Example 11)
Show SMILES CC1(C)CC(=O)N(Cc2ccc(cc2)C(=O)NO)c2ccc(Cl)cc12
Show InChI InChI=1S/C19H19ClN2O3/c1-19(2)10-17(23)22(16-8-7-14(20)9-15(16)19)11-12-3-5-13(6-4-12)18(24)21-25/h3-9,25H,10-11H2,1-2H3,(H,21,24)
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n/an/a 6.50E+3n/an/an/an/an/an/a



THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS

US Patent


Assay Description
The effectiveness, or potency, of a present HDACI with respect to inhibiting the activity of an HDAC is measured by an IC50 value. The quantitative I...


US Patent US10456394 (2019)


BindingDB Entry DOI: 10.7270/Q2Q81GFW
More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))
BDBM417119
PNG
(US10456394, Example 14 | US10456394, Example 15)
Show SMILES COC(=O)c1ccc(CN2CCN(C(=O)OC(C)(C)C)c3ccccc23)cc1
Show InChI InChI=1S/C22H26N2O4/c1-22(2,3)28-21(26)24-14-13-23(18-7-5-6-8-19(18)24)15-16-9-11-17(12-10-16)20(25)27-4/h5-12H,13-15H2,1-4H3
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n/an/a 6.69E+3n/an/an/an/an/an/a



THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS

US Patent


Assay Description
The effectiveness, or potency, of a present HDACI with respect to inhibiting the activity of an HDAC is measured by an IC50 value. The quantitative I...


US Patent US10456394 (2019)


BindingDB Entry DOI: 10.7270/Q2Q81GFW
More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))
BDBM417121
PNG
(US10456394, Example 16)
Show SMILES ONC(=O)c1ccc(CN2CCSc3ccccc23)cc1
Show InChI InChI=1S/C16H16N2O2S/c19-16(17-20)13-7-5-12(6-8-13)11-18-9-10-21-15-4-2-1-3-14(15)18/h1-8,20H,9-11H2,(H,17,19)
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n/an/a 7.94E+3n/an/an/an/an/an/a



THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS

US Patent


Assay Description
The effectiveness, or potency, of a present HDACI with respect to inhibiting the activity of an HDAC is measured by an IC50 value. The quantitative I...


US Patent US10456394 (2019)


BindingDB Entry DOI: 10.7270/Q2Q81GFW
More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))
BDBM417066
PNG
(US10456394, Example 4)
Show SMILES CC(N1CCCc2cc(Cl)ccc12)c1ccc(cc1)C(=O)NO
Show InChI InChI=1S/C18H19ClN2O2/c1-12(13-4-6-14(7-5-13)18(22)20-23)21-10-2-3-15-11-16(19)8-9-17(15)21/h4-9,11-12,23H,2-3,10H2,1H3,(H,20,22)
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n/an/a 8.43E+3n/an/an/an/an/an/a



THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS

US Patent


Assay Description
The effectiveness, or potency, of a present HDACI with respect to inhibiting the activity of an HDAC is measured by an IC50 value. The quantitative I...


US Patent US10456394 (2019)


BindingDB Entry DOI: 10.7270/Q2Q81GFW
More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))
BDBM417119
PNG
(US10456394, Example 14 | US10456394, Example 15)
Show SMILES COC(=O)c1ccc(CN2CCN(C(=O)OC(C)(C)C)c3ccccc23)cc1
Show InChI InChI=1S/C22H26N2O4/c1-22(2,3)28-21(26)24-14-13-23(18-7-5-6-8-19(18)24)15-16-9-11-17(12-10-16)20(25)27-4/h5-12H,13-15H2,1-4H3
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n/an/a 8.75E+3n/an/an/an/an/an/a



THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS

US Patent


Assay Description
The effectiveness, or potency, of a present HDACI with respect to inhibiting the activity of an HDAC is measured by an IC50 value. The quantitative I...


US Patent US10456394 (2019)


BindingDB Entry DOI: 10.7270/Q2Q81GFW
More data for this
Ligand-Target Pair
Histone deacetylase 4


(Homo sapiens (Human))
BDBM417049
PNG
(4-((6-chloro-3,4-dihydroquinolin-1(2H)-yl)methyl)-...)
Show SMILES ONC(=O)c1ccc(CN2CCCc3cc(Cl)ccc23)cc1
Show InChI InChI=1S/C17H17ClN2O2/c18-15-7-8-16-14(10-15)2-1-9-20(16)11-12-3-5-13(6-4-12)17(21)19-22/h3-8,10,22H,1-2,9,11H2,(H,19,21)
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n/an/a 1.10E+4n/an/an/an/an/an/a



THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS

US Patent


Assay Description
The effectiveness, or potency, of a present HDACI with respect to inhibiting the activity of an HDAC is measured by an IC50 value. The quantitative I...


US Patent US10456394 (2019)


BindingDB Entry DOI: 10.7270/Q2Q81GFW
More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))
BDBM417063
PNG
(4-((3,4-dihydroquinolin-1(2H)-yl)methyl)-N-hydroxy...)
Show SMILES ONC(=O)c1ccc(CN2CCCc3ccccc23)cc1
Show InChI InChI=1S/C17H18N2O2/c20-17(18-21)15-9-7-13(8-10-15)12-19-11-3-5-14-4-1-2-6-16(14)19/h1-2,4,6-10,21H,3,5,11-12H2,(H,18,20)
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n/an/a 1.11E+4n/an/an/an/an/an/a



THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS

US Patent


Assay Description
The effectiveness, or potency, of a present HDACI with respect to inhibiting the activity of an HDAC is measured by an IC50 value. The quantitative I...


US Patent US10456394 (2019)


BindingDB Entry DOI: 10.7270/Q2Q81GFW
More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))
BDBM50380399
PNG
(CHEMBL2018302 | Tubastatin A | US10227295, Compoun...)
Show SMILES CN1CCc2c(C1)c1ccccc1n2Cc1ccc(cc1)C(=O)NO
Show InChI InChI=1S/C20H21N3O2/c1-22-11-10-19-17(13-22)16-4-2-3-5-18(16)23(19)12-14-6-8-15(9-7-14)20(24)21-25/h2-9,25H,10-13H2,1H3,(H,21,24)
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n/an/a 1.18E+4n/an/an/an/an/an/a



THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS

US Patent


Assay Description
The effectiveness, or potency, of a present HDACI with respect to inhibiting the activity of an HDAC is measured by an IC50 value. The quantitative I...


US Patent US10456394 (2019)


BindingDB Entry DOI: 10.7270/Q2Q81GFW
More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))
BDBM417100
PNG
(US10456394, Example 10)
Show SMILES CC1(C)CCc2cc(F)ccc2N1Cc1ccc(cc1)C(=O)NO
Show InChI InChI=1S/C19H21FN2O2/c1-19(2)10-9-15-11-16(20)7-8-17(15)22(19)12-13-3-5-14(6-4-13)18(23)21-24/h3-8,11,24H,9-10,12H2,1-2H3,(H,21,23)
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n/an/a 1.41E+4n/an/an/an/an/an/a



THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS

US Patent


Assay Description
The effectiveness, or potency, of a present HDACI with respect to inhibiting the activity of an HDAC is measured by an IC50 value. The quantitative I...


US Patent US10456394 (2019)


BindingDB Entry DOI: 10.7270/Q2Q81GFW
More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))
BDBM50380399
PNG
(CHEMBL2018302 | Tubastatin A | US10227295, Compoun...)
Show SMILES CN1CCc2c(C1)c1ccccc1n2Cc1ccc(cc1)C(=O)NO
Show InChI InChI=1S/C20H21N3O2/c1-22-11-10-19-17(13-22)16-4-2-3-5-18(16)23(19)12-14-6-8-15(9-7-14)20(24)21-25/h2-9,25H,10-13H2,1H3,(H,21,24)
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n/an/a 1.64E+4n/an/an/an/an/an/a



THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS

US Patent


Assay Description
The effectiveness, or potency, of a present HDACI with respect to inhibiting the activity of an HDAC is measured by an IC50 value. The quantitative I...


US Patent US10456394 (2019)


BindingDB Entry DOI: 10.7270/Q2Q81GFW
More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))
BDBM417117
PNG
(US10456394, Example 12)
Show SMILES CC1(C)CCN(Cc2ccc(cc2)C(=O)NO)c2ccc(Cl)cc12
Show InChI InChI=1S/C19H21ClN2O2/c1-19(2)9-10-22(17-8-7-15(20)11-16(17)19)12-13-3-5-14(6-4-13)18(23)21-24/h3-8,11,24H,9-10,12H2,1-2H3,(H,21,23)
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n/an/a 1.95E+4n/an/an/an/an/an/a



THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS

US Patent


Assay Description
The effectiveness, or potency, of a present HDACI with respect to inhibiting the activity of an HDAC is measured by an IC50 value. The quantitative I...


US Patent US10456394 (2019)


BindingDB Entry DOI: 10.7270/Q2Q81GFW
More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))
BDBM417080
PNG
(US10456394, Example 9)
Show SMILES CC1(C)CCc2cc(Cl)ccc2N1Cc1ccc(cc1)C(=O)NO
Show InChI InChI=1S/C19H21ClN2O2/c1-19(2)10-9-15-11-16(20)7-8-17(15)22(19)12-13-3-5-14(6-4-13)18(23)21-24/h3-8,11,24H,9-10,12H2,1-2H3,(H,21,23)
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n/an/a 1.96E+4n/an/an/an/an/an/a



THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS

US Patent


Assay Description
The effectiveness, or potency, of a present HDACI with respect to inhibiting the activity of an HDAC is measured by an IC50 value. The quantitative I...


US Patent US10456394 (2019)


BindingDB Entry DOI: 10.7270/Q2Q81GFW
More data for this
Ligand-Target Pair
Histone deacetylase 11


(Homo sapiens (Human))
BDBM50380399
PNG
(CHEMBL2018302 | Tubastatin A | US10227295, Compoun...)
Show SMILES CN1CCc2c(C1)c1ccccc1n2Cc1ccc(cc1)C(=O)NO
Show InChI InChI=1S/C20H21N3O2/c1-22-11-10-19-17(13-22)16-4-2-3-5-18(16)23(19)12-14-6-8-15(9-7-14)20(24)21-25/h2-9,25H,10-13H2,1H3,(H,21,24)
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n/an/a 1.97E+4n/an/an/an/an/an/a



THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS

US Patent


Assay Description
The effectiveness, or potency, of a present HDACI with respect to inhibiting the activity of an HDAC is measured by an IC50 value. The quantitative I...


US Patent US10456394 (2019)


BindingDB Entry DOI: 10.7270/Q2Q81GFW
More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))
BDBM417118
PNG
(US10456394, Example 13)
Show SMILES CC1(C)CCN(Cc2ccc(cc2)C(=O)NO)c2ccc(F)cc12
Show InChI InChI=1S/C19H21FN2O2/c1-19(2)9-10-22(17-8-7-15(20)11-16(17)19)12-13-3-5-14(6-4-13)18(23)21-24/h3-8,11,24H,9-10,12H2,1-2H3,(H,21,23)
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n/an/a 2.11E+4n/an/an/an/an/an/a



THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS

US Patent


Assay Description
The effectiveness, or potency, of a present HDACI with respect to inhibiting the activity of an HDAC is measured by an IC50 value. The quantitative I...


US Patent US10456394 (2019)


BindingDB Entry DOI: 10.7270/Q2Q81GFW
More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))
BDBM417065
PNG
(4-((6-chloro-3,4-dihydroquinolin-1(2H)-yl)methyl)-...)
Show SMILES ONC(=O)c1ccc(CN2CCCc3cc(Cl)ccc23)c(F)c1
Show InChI InChI=1S/C17H16ClFN2O2/c18-14-5-6-16-11(8-14)2-1-7-21(16)10-13-4-3-12(9-15(13)19)17(22)20-23/h3-6,8-9,23H,1-2,7,10H2,(H,20,22)
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n/an/a 2.12E+4n/an/an/an/an/an/a



THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS

US Patent


Assay Description
The effectiveness, or potency, of a present HDACI with respect to inhibiting the activity of an HDAC is measured by an IC50 value. The quantitative I...


US Patent US10456394 (2019)


BindingDB Entry DOI: 10.7270/Q2Q81GFW
More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))
BDBM417124
PNG
(US10456394, Example 18 | US10456394, Example 19)
Show SMILES CC(C)(C)OC(=O)N1CC(=O)N(Cc2ccc(cc2)C(=O)NO)c2ccccc12
Show InChI InChI=1S/C21H23N3O5/c1-21(2,3)29-20(27)24-13-18(25)23(16-6-4-5-7-17(16)24)12-14-8-10-15(11-9-14)19(26)22-28/h4-11,28H,12-13H2,1-3H3,(H,22,26)
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n/an/a 2.20E+4n/an/an/an/an/an/a



THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS

US Patent


Assay Description
The effectiveness, or potency, of a present HDACI with respect to inhibiting the activity of an HDAC is measured by an IC50 value. The quantitative I...


US Patent US10456394 (2019)


BindingDB Entry DOI: 10.7270/Q2Q81GFW
More data for this
Ligand-Target Pair
Histone deacetylase 2


(Homo sapiens (Human))
BDBM50380399
PNG
(CHEMBL2018302 | Tubastatin A | US10227295, Compoun...)
Show SMILES CN1CCc2c(C1)c1ccccc1n2Cc1ccc(cc1)C(=O)NO
Show InChI InChI=1S/C20H21N3O2/c1-22-11-10-19-17(13-22)16-4-2-3-5-18(16)23(19)12-14-6-8-15(9-7-14)20(24)21-25/h2-9,25H,10-13H2,1H3,(H,21,24)
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n/an/a 2.54E+4n/an/an/an/an/an/a



THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS

US Patent


Assay Description
The effectiveness, or potency, of a present HDACI with respect to inhibiting the activity of an HDAC is measured by an IC50 value. The quantitative I...


US Patent US10456394 (2019)


BindingDB Entry DOI: 10.7270/Q2Q81GFW
More data for this
Ligand-Target Pair
Histone deacetylase 3


(Homo sapiens (Human))
BDBM417049
PNG
(4-((6-chloro-3,4-dihydroquinolin-1(2H)-yl)methyl)-...)
Show SMILES ONC(=O)c1ccc(CN2CCCc3cc(Cl)ccc23)cc1
Show InChI InChI=1S/C17H17ClN2O2/c18-15-7-8-16-14(10-15)2-1-9-20(16)11-12-3-5-13(6-4-12)17(21)19-22/h3-8,10,22H,1-2,9,11H2,(H,19,21)
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n/an/a>3.00E+4n/an/an/an/an/an/a



THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS

US Patent


Assay Description
The effectiveness, or potency, of a present HDACI with respect to inhibiting the activity of an HDAC is measured by an IC50 value. The quantitative I...


US Patent US10456394 (2019)


BindingDB Entry DOI: 10.7270/Q2Q81GFW
More data for this
Ligand-Target Pair
Histone deacetylase 2


(Homo sapiens (Human))
BDBM417049
PNG
(4-((6-chloro-3,4-dihydroquinolin-1(2H)-yl)methyl)-...)
Show SMILES ONC(=O)c1ccc(CN2CCCc3cc(Cl)ccc23)cc1
Show InChI InChI=1S/C17H17ClN2O2/c18-15-7-8-16-14(10-15)2-1-9-20(16)11-12-3-5-13(6-4-12)17(21)19-22/h3-8,10,22H,1-2,9,11H2,(H,19,21)
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n/an/a>3.00E+4n/an/an/an/an/an/a



THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS

US Patent


Assay Description
The effectiveness, or potency, of a present HDACI with respect to inhibiting the activity of an HDAC is measured by an IC50 value. The quantitative I...


US Patent US10456394 (2019)


BindingDB Entry DOI: 10.7270/Q2Q81GFW
More data for this
Ligand-Target Pair
Histone deacetylase 10


(Homo sapiens (Human))
BDBM417049
PNG
(4-((6-chloro-3,4-dihydroquinolin-1(2H)-yl)methyl)-...)
Show SMILES ONC(=O)c1ccc(CN2CCCc3cc(Cl)ccc23)cc1
Show InChI InChI=1S/C17H17ClN2O2/c18-15-7-8-16-14(10-15)2-1-9-20(16)11-12-3-5-13(6-4-12)17(21)19-22/h3-8,10,22H,1-2,9,11H2,(H,19,21)
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n/an/a>3.00E+4n/an/an/an/an/an/a



THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS

US Patent


Assay Description
The effectiveness, or potency, of a present HDACI with respect to inhibiting the activity of an HDAC is measured by an IC50 value. The quantitative I...


US Patent US10456394 (2019)


BindingDB Entry DOI: 10.7270/Q2Q81GFW
More data for this
Ligand-Target Pair
Histone deacetylase 10


(Homo sapiens (Human))
BDBM50380399
PNG
(CHEMBL2018302 | Tubastatin A | US10227295, Compoun...)
Show SMILES CN1CCc2c(C1)c1ccccc1n2Cc1ccc(cc1)C(=O)NO
Show InChI InChI=1S/C20H21N3O2/c1-22-11-10-19-17(13-22)16-4-2-3-5-18(16)23(19)12-14-6-8-15(9-7-14)20(24)21-25/h2-9,25H,10-13H2,1H3,(H,21,24)
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US Patent
n/an/a 3.84E+4n/an/an/an/an/an/a



THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS

US Patent


Assay Description
The effectiveness, or potency, of a present HDACI with respect to inhibiting the activity of an HDAC is measured by an IC50 value. The quantitative I...


US Patent US10456394 (2019)


BindingDB Entry DOI: 10.7270/Q2Q81GFW
More data for this
Ligand-Target Pair
Histone deacetylase 3


(Homo sapiens (Human))
BDBM50380399
PNG
(CHEMBL2018302 | Tubastatin A | US10227295, Compoun...)
Show SMILES CN1CCc2c(C1)c1ccccc1n2Cc1ccc(cc1)C(=O)NO
Show InChI InChI=1S/C20H21N3O2/c1-22-11-10-19-17(13-22)16-4-2-3-5-18(16)23(19)12-14-6-8-15(9-7-14)20(24)21-25/h2-9,25H,10-13H2,1H3,(H,21,24)
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US Patent
n/an/a 8.17E+4n/an/an/an/an/an/a



THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS

US Patent


Assay Description
The effectiveness, or potency, of a present HDACI with respect to inhibiting the activity of an HDAC is measured by an IC50 value. The quantitative I...


US Patent US10456394 (2019)


BindingDB Entry DOI: 10.7270/Q2Q81GFW
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%