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Patent code US10457637

Compile Data Set for Download or QSAR
Found 170 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Nuclear receptor ROR-gamma (RORC)


(Homo sapiens (Human))
BDBM419169
PNG
(N-(4-ethylphenyl)-N- isobutyl-3-(S- methylsulfonom...)
Show SMILES CCc1ccc(cc1)N(CC(C)C)S(=O)(=O)c1ccc(OCC2CCSCC2)c(c1)S(C)(=N)=O
Show InChI InChI=1/C25H36N2O4S3/c1-5-20-6-8-22(9-7-20)27(17-19(2)3)34(29,30)23-10-11-24(25(16-23)33(4,26)28)31-18-21-12-14-32-15-13-21/h6-11,16,19,21,26H,5,12-15,17-18H2,1-4H3
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US Patent
n/an/a<100n/an/an/an/an/an/a



GALDERMA RESEARCH & DEVELOPMENT

US Patent


Assay Description
The RORγ transactivation model was developed from the line HG5LN, which is a HeLa line that stably expresses a luciferase reporter gene controll...


US Patent US10457637 (2019)

More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma (RORC)


(Homo sapiens (Human))
BDBM419218
PNG
(4-((((1R,5S,6S)-3- oxabicyclo[3.1.0]hexan-6- yl)me...)
Show SMILES CCc1ccc(cc1)N(CC(C)C)S(=O)(=O)c1ccc(NC[C@H]2[C@@H]3COC[C@H]23)c(c1)S(C)(=N)=O
Show InChI InChI=1/C25H35N3O4S2/c1-5-18-6-8-19(9-7-18)28(14-17(2)3)34(30,31)20-10-11-24(25(12-20)33(4,26)29)27-13-21-22-15-32-16-23(21)22/h6-12,17,21-23,26-27H,5,13-16H2,1-4H3/t21-,22-,23+,33?
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n/an/a<100n/an/an/an/an/an/a



GALDERMA RESEARCH & DEVELOPMENT

US Patent


Assay Description
The RORγ transactivation model was developed from the line HG5LN, which is a HeLa line that stably expresses a luciferase reporter gene controll...


US Patent US10457637 (2019)

More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma (RORC)


(Homo sapiens (Human))
BDBM419139
PNG
(BDBM50461078 | N-(4-ethylphenyl)-N- isobutyl-3- me...)
Show SMILES CCc1ccc(cc1)N(CC(C)C)S(=O)(=O)c1ccc(OCC2CCOCC2)c(c1)S(C)(N)=O
Show InChI InChI=1S/C25H38N2O5S2/c1-5-20-6-8-22(9-7-20)27(17-19(2)3)34(29,30)23-10-11-24(25(16-23)33(4,26)28)32-18-21-12-14-31-15-13-21/h6-11,16,19,21,33H,5,12-15,17-18H2,1-4H3,(H2,26,28)
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n/an/a<100n/an/an/an/an/an/a



GALDERMA RESEARCH & DEVELOPMENT

US Patent


Assay Description
The RORγ transactivation model was developed from the line HG5LN, which is a HeLa line that stably expresses a luciferase reporter gene controll...


US Patent US10457637 (2019)

More data for this
Ligand-Target Pair
Interleukin-17A


(Homo sapiens (Human))
BDBM50461065
PNG
(CHEMBL4225020 | US10457637, Compound 18)
Show SMILES CCc1ccc(cc1)N(CC(C)C)S(=O)(=O)c1ccc(OCC2CCOCC2)c(c1)S(=N)(=O)CC
Show InChI InChI=1S/C26H38N2O5S2/c1-5-21-7-9-23(10-8-21)28(18-20(3)4)35(30,31)24-11-12-25(26(17-24)34(27,29)6-2)33-19-22-13-15-32-16-14-22/h7-12,17,20,22,27H,5-6,13-16,18-19H2,1-4H3
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n/an/a<100n/an/an/an/an/an/a



GALDERMA RESEARCH & DEVELOPMENT

US Patent


Assay Description
This model allows measurement of the effect of inhibitors on IL-17A secretion by CD4+ cells. The cells are frozen CD4+ cells (STEMCELL, #70026), isol...


US Patent US10457637 (2019)

More data for this
Ligand-Target Pair
Interleukin-17A


(Homo sapiens (Human))
BDBM50461068
PNG
(CHEMBL4228069 | US10457637, Compound 24)
Show SMILES CCc1ccc(cc1)N(CC(C)C)S(=O)(=O)c1ccc(OCC2CCOCC2)c(c1)S(C)(=O)=O
Show InChI InChI=1S/C25H35NO6S2/c1-5-20-6-8-22(9-7-20)26(17-19(2)3)34(29,30)23-10-11-24(25(16-23)33(4,27)28)32-18-21-12-14-31-15-13-21/h6-11,16,19,21H,5,12-15,17-18H2,1-4H3
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n/an/a<100n/an/an/an/an/an/a



GALDERMA RESEARCH & DEVELOPMENT

US Patent


Assay Description
This model allows measurement of the effect of inhibitors on IL-17A secretion by CD4+ cells. The cells are frozen CD4+ cells (STEMCELL, #70026), isol...


US Patent US10457637 (2019)

More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma (RORC)


(Homo sapiens (Human))
BDBM50461074
PNG
(CHEMBL4227729 | US10457637, Compound 52)
Show SMILES CCc1ccc(cc1)N(CC(C)C)S(=O)(=O)c1ccc(NCC2CCOCC2)c(c1)S(C)(=N)=O
Show InChI InChI=1S/C25H37N3O4S2/c1-5-20-6-8-22(9-7-20)28(18-19(2)3)34(30,31)23-10-11-24(25(16-23)33(4,26)29)27-17-21-12-14-32-15-13-21/h6-11,16,19,21,26-27H,5,12-15,17-18H2,1-4H3
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n/an/a<100n/an/an/an/an/an/a



GALDERMA RESEARCH & DEVELOPMENT

US Patent


Assay Description
The RORγ transactivation model was developed from the line HG5LN, which is a HeLa line that stably expresses a luciferase reporter gene controll...


US Patent US10457637 (2019)

More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma (RORC)


(Homo sapiens (Human))
BDBM419214
PNG
(N-(4-ethylphenyl)-N- isobutyl-3-(S- methylsulfonim...)
Show SMILES CCc1ccc(cc1)N(CC(C)C)S(=O)(=O)c1ccc(N2CCSCC2)c(c1)S(C)(=N)=O
Show InChI InChI=1/C23H33N3O3S3/c1-5-19-6-8-20(9-7-19)26(17-18(2)3)32(28,29)21-10-11-22(23(16-21)31(4,24)27)25-12-14-30-15-13-25/h6-11,16,18,24H,5,12-15,17H2,1-4H3
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n/an/a<100n/an/an/an/an/an/a



GALDERMA RESEARCH & DEVELOPMENT

US Patent


Assay Description
The RORγ transactivation model was developed from the line HG5LN, which is a HeLa line that stably expresses a luciferase reporter gene controll...


US Patent US10457637 (2019)

More data for this
Ligand-Target Pair
Interleukin-17A


(Homo sapiens (Human))
BDBM419225
PNG
(N-(4-ethylphenyl)-N- isobutyl-3-(S- methylsulfonim...)
Show SMILES CCc1ccc(cc1)N(CC(C)C)S(=O)(=O)c1ccc(NCC2CSC2)c(c1)S(C)(=N)=O
Show InChI InChI=1/C23H33N3O3S3/c1-5-18-6-8-20(9-7-18)26(14-17(2)3)32(28,29)21-10-11-22(23(12-21)31(4,24)27)25-13-19-15-30-16-19/h6-12,17,19,24-25H,5,13-16H2,1-4H3
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n/an/a<100n/an/an/an/an/an/a



GALDERMA RESEARCH & DEVELOPMENT

US Patent


Assay Description
This model allows measurement of the effect of inhibitors on IL-17A secretion by CD4+ cells. The cells are frozen CD4+ cells (STEMCELL, #70026), isol...


US Patent US10457637 (2019)

More data for this
Ligand-Target Pair
Interleukin-17A


(Homo sapiens (Human))
BDBM419139
PNG
(BDBM50461078 | N-(4-ethylphenyl)-N- isobutyl-3- me...)
Show SMILES CCc1ccc(cc1)N(CC(C)C)S(=O)(=O)c1ccc(OCC2CCOCC2)c(c1)S(C)(N)=O
Show InChI InChI=1S/C25H38N2O5S2/c1-5-20-6-8-22(9-7-20)27(17-19(2)3)34(29,30)23-10-11-24(25(16-23)33(4,26)28)32-18-21-12-14-31-15-13-21/h6-11,16,19,21,33H,5,12-15,17-18H2,1-4H3,(H2,26,28)
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n/an/a<100n/an/an/an/an/an/a



GALDERMA RESEARCH & DEVELOPMENT

US Patent


Assay Description
This model allows measurement of the effect of inhibitors on IL-17A secretion by CD4+ cells. The cells are frozen CD4+ cells (STEMCELL, #70026), isol...


US Patent US10457637 (2019)

More data for this
Ligand-Target Pair
Interleukin-17A


(Homo sapiens (Human))
BDBM50461066
PNG
(CHEMBL4228566 | US10457637, Compound 53)
Show SMILES CCc1ccc(cc1)N(CC(C)C)S(=O)(=O)c1ccc(N(C)CC2CCOCC2)c(c1)S(C)(=N)=O
Show InChI InChI=1S/C26H39N3O4S2/c1-6-21-7-9-23(10-8-21)29(18-20(2)3)35(31,32)24-11-12-25(26(17-24)34(5,27)30)28(4)19-22-13-15-33-16-14-22/h7-12,17,20,22,27H,6,13-16,18-19H2,1-5H3
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n/an/a<100n/an/an/an/an/an/a



GALDERMA RESEARCH & DEVELOPMENT

US Patent


Assay Description
This model allows measurement of the effect of inhibitors on IL-17A secretion by CD4+ cells. The cells are frozen CD4+ cells (STEMCELL, #70026), isol...


US Patent US10457637 (2019)

More data for this
Ligand-Target Pair
Interleukin-17A


(Homo sapiens (Human))
BDBM50461069
PNG
(CHEMBL4228522 | US10457637, Compound 66)
Show SMILES CCc1ccc(cc1)N(CC(C)C)S(=O)(=O)c1ccc(OCC2CCOCC2)c(c1)S(N)(=O)=O
Show InChI InChI=1S/C24H34N2O6S2/c1-4-19-5-7-21(8-6-19)26(16-18(2)3)34(29,30)22-9-10-23(24(15-22)33(25,27)28)32-17-20-11-13-31-14-12-20/h5-10,15,18,20H,4,11-14,16-17H2,1-3H3,(H2,25,27,28)
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n/an/a<100n/an/an/an/an/an/a



GALDERMA RESEARCH & DEVELOPMENT

US Patent


Assay Description
This model allows measurement of the effect of inhibitors on IL-17A secretion by CD4+ cells. The cells are frozen CD4+ cells (STEMCELL, #70026), isol...


US Patent US10457637 (2019)

More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma (RORC)


(Homo sapiens (Human))
BDBM419192
PNG
(N-(4-ethylphenyl)-N- isobutyl-3-(S- methylsulfonim...)
Show SMILES CCc1ccc(cc1)N(CC(C)C)S(=O)(=O)c1ccc(NCc2ccncc2)c(c1)S(C)(=N)=O
Show InChI InChI=1/C25H32N4O3S2/c1-5-20-6-8-22(9-7-20)29(18-19(2)3)34(31,32)23-10-11-24(25(16-23)33(4,26)30)28-17-21-12-14-27-15-13-21/h6-16,19,26,28H,5,17-18H2,1-4H3
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n/an/a<100n/an/an/an/an/an/a



GALDERMA RESEARCH & DEVELOPMENT

US Patent


Assay Description
The RORγ transactivation model was developed from the line HG5LN, which is a HeLa line that stably expresses a luciferase reporter gene controll...


US Patent US10457637 (2019)

More data for this
Ligand-Target Pair
Interleukin-17A


(Homo sapiens (Human))
BDBM419214
PNG
(N-(4-ethylphenyl)-N- isobutyl-3-(S- methylsulfonim...)
Show SMILES CCc1ccc(cc1)N(CC(C)C)S(=O)(=O)c1ccc(N2CCSCC2)c(c1)S(C)(=N)=O
Show InChI InChI=1/C23H33N3O3S3/c1-5-19-6-8-20(9-7-19)26(17-18(2)3)32(28,29)21-10-11-22(23(16-21)31(4,24)27)25-12-14-30-15-13-25/h6-11,16,18,24H,5,12-15,17H2,1-4H3
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n/an/a<100n/an/an/an/an/an/a



GALDERMA RESEARCH & DEVELOPMENT

US Patent


Assay Description
This model allows measurement of the effect of inhibitors on IL-17A secretion by CD4+ cells. The cells are frozen CD4+ cells (STEMCELL, #70026), isol...


US Patent US10457637 (2019)

More data for this
Ligand-Target Pair
Interleukin-17A


(Homo sapiens (Human))
BDBM419234
PNG
(N-(4-ethylphenyl)-N- isobutyl-3-(S- methylsulfonim...)
Show SMILES CCc1ccc(cc1)N(CC(C)C)S(=O)(=O)c1ccc(N2CCC3(COC3)C2)c(c1)S(C)(=N)=O
Show InChI InChI=1/C25H35N3O4S2/c1-5-20-6-8-21(9-7-20)28(15-19(2)3)34(30,31)22-10-11-23(24(14-22)33(4,26)29)27-13-12-25(16-27)17-32-18-25/h6-11,14,19,26H,5,12-13,15-18H2,1-4H3
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n/an/a<100n/an/an/an/an/an/a



GALDERMA RESEARCH & DEVELOPMENT

US Patent


Assay Description
This model allows measurement of the effect of inhibitors on IL-17A secretion by CD4+ cells. The cells are frozen CD4+ cells (STEMCELL, #70026), isol...


US Patent US10457637 (2019)

More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma (RORC)


(Homo sapiens (Human))
BDBM419242
PNG
(N-(4-ethylphenyl)-N- isobutyl-3-(S- methylsulfonim...)
Show SMILES CCc1ccc(cc1)N(CC(C)C)S(=O)(=O)c1ccc(N2CCOCC2)c(c1)S(C)(=N)=O
Show InChI InChI=1/C23H33N3O4S2/c1-5-19-6-8-20(9-7-19)26(17-18(2)3)32(28,29)21-10-11-22(23(16-21)31(4,24)27)25-12-14-30-15-13-25/h6-11,16,18,24H,5,12-15,17H2,1-4H3
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n/an/a<100n/an/an/an/an/an/a



GALDERMA RESEARCH & DEVELOPMENT

US Patent


Assay Description
The RORγ transactivation model was developed from the line HG5LN, which is a HeLa line that stably expresses a luciferase reporter gene controll...


US Patent US10457637 (2019)

More data for this
Ligand-Target Pair
Interleukin-17A


(Homo sapiens (Human))
BDBM419242
PNG
(N-(4-ethylphenyl)-N- isobutyl-3-(S- methylsulfonim...)
Show SMILES CCc1ccc(cc1)N(CC(C)C)S(=O)(=O)c1ccc(N2CCOCC2)c(c1)S(C)(=N)=O
Show InChI InChI=1/C23H33N3O4S2/c1-5-19-6-8-20(9-7-19)26(17-18(2)3)32(28,29)21-10-11-22(23(16-21)31(4,24)27)25-12-14-30-15-13-25/h6-11,16,18,24H,5,12-15,17H2,1-4H3
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n/an/a<100n/an/an/an/an/an/a



GALDERMA RESEARCH & DEVELOPMENT

US Patent


Assay Description
This model allows measurement of the effect of inhibitors on IL-17A secretion by CD4+ cells. The cells are frozen CD4+ cells (STEMCELL, #70026), isol...


US Patent US10457637 (2019)

More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma (RORC)


(Homo sapiens (Human))
BDBM50461076
PNG
(CHEMBL4227214 | US10457637, Compound 124)
Show SMILES CCc1ccc(cc1)N(CC(C)C)S(=O)(=O)c1ccc(NCC2(CC)CCOCC2)c(c1)S(C)(=N)=O
Show InChI InChI=1S/C27H41N3O4S2/c1-6-22-8-10-23(11-9-22)30(19-21(3)4)36(32,33)24-12-13-25(26(18-24)35(5,28)31)29-20-27(7-2)14-16-34-17-15-27/h8-13,18,21,28-29H,6-7,14-17,19-20H2,1-5H3
PDB

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n/an/a<100n/an/an/an/an/an/a



GALDERMA RESEARCH & DEVELOPMENT

US Patent


Assay Description
The RORγ transactivation model was developed from the line HG5LN, which is a HeLa line that stably expresses a luciferase reporter gene controll...


US Patent US10457637 (2019)

More data for this
Ligand-Target Pair
Interleukin-17A


(Homo sapiens (Human))
BDBM419139
PNG
(BDBM50461078 | N-(4-ethylphenyl)-N- isobutyl-3- me...)
Show SMILES CCc1ccc(cc1)N(CC(C)C)S(=O)(=O)c1ccc(OCC2CCOCC2)c(c1)S(C)(N)=O
Show InChI InChI=1S/C25H38N2O5S2/c1-5-20-6-8-22(9-7-20)27(17-19(2)3)34(29,30)23-10-11-24(25(16-23)33(4,26)28)32-18-21-12-14-31-15-13-21/h6-11,16,19,21,33H,5,12-15,17-18H2,1-4H3,(H2,26,28)
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n/an/a<100n/an/an/an/an/an/a



GALDERMA RESEARCH & DEVELOPMENT

US Patent


Assay Description
This model allows measurement of the effect of inhibitors on IL-17A secretion by CD4+ cells. The cells are frozen CD4+ cells (STEMCELL, #70026), isol...


US Patent US10457637 (2019)

More data for this
Ligand-Target Pair
Interleukin-17A


(Homo sapiens (Human))
BDBM419155
PNG
(N-(4-ethylphenyl)-N- isobutyl-3-methanesulfinyl- 4...)
Show SMILES CCc1ccc(cc1)N(CC(C)C)S(=O)(=O)c1ccc(OCC2CCOCC2)c(c1)[S@@](C)=O
Show InChI InChI=1/C25H35NO5S2/c1-5-20-6-8-22(9-7-20)26(17-19(2)3)33(28,29)23-10-11-24(25(16-23)32(4)27)31-18-21-12-14-30-15-13-21/h6-11,16,19,21H,5,12-15,17-18H2,1-4H3/t32-/s2
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n/an/a<100n/an/an/an/an/an/a



GALDERMA RESEARCH & DEVELOPMENT

US Patent


Assay Description
This model allows measurement of the effect of inhibitors on IL-17A secretion by CD4+ cells. The cells are frozen CD4+ cells (STEMCELL, #70026), isol...


US Patent US10457637 (2019)

More data for this
Ligand-Target Pair
Interleukin-17A


(Homo sapiens (Human))
BDBM50461083
PNG
(CHEMBL4225889 | US10457637, Compound 62)
Show SMILES CCc1ccc(cc1)N(CC(C)C)S(=O)(=O)c1ccc(NCC2(F)CCOCC2)c(c1)S(C)(=N)=O
Show InChI InChI=1S/C25H36FN3O4S2/c1-5-20-6-8-21(9-7-20)29(17-19(2)3)35(31,32)22-10-11-23(24(16-22)34(4,27)30)28-18-25(26)12-14-33-15-13-25/h6-11,16,19,27-28H,5,12-15,17-18H2,1-4H3
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n/an/a<100n/an/an/an/an/an/a



GALDERMA RESEARCH & DEVELOPMENT

US Patent


Assay Description
This model allows measurement of the effect of inhibitors on IL-17A secretion by CD4+ cells. The cells are frozen CD4+ cells (STEMCELL, #70026), isol...


US Patent US10457637 (2019)

More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma (RORC)


(Homo sapiens (Human))
BDBM50461083
PNG
(CHEMBL4225889 | US10457637, Compound 62)
Show SMILES CCc1ccc(cc1)N(CC(C)C)S(=O)(=O)c1ccc(NCC2(F)CCOCC2)c(c1)S(C)(=N)=O
Show InChI InChI=1S/C25H36FN3O4S2/c1-5-20-6-8-21(9-7-20)29(17-19(2)3)35(31,32)22-10-11-23(24(16-22)34(4,27)30)28-18-25(26)12-14-33-15-13-25/h6-11,16,19,27-28H,5,12-15,17-18H2,1-4H3
PDB

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n/an/a<100n/an/an/an/an/an/a



GALDERMA RESEARCH & DEVELOPMENT

US Patent


Assay Description
The RORγ transactivation model was developed from the line HG5LN, which is a HeLa line that stably expresses a luciferase reporter gene controll...


US Patent US10457637 (2019)

More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma (RORC)


(Homo sapiens (Human))
BDBM419225
PNG
(N-(4-ethylphenyl)-N- isobutyl-3-(S- methylsulfonim...)
Show SMILES CCc1ccc(cc1)N(CC(C)C)S(=O)(=O)c1ccc(NCC2CSC2)c(c1)S(C)(=N)=O
Show InChI InChI=1/C23H33N3O3S3/c1-5-18-6-8-20(9-7-18)26(14-17(2)3)32(28,29)21-10-11-22(23(12-21)31(4,24)27)25-13-19-15-30-16-19/h6-12,17,19,24-25H,5,13-16H2,1-4H3
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n/an/a<100n/an/an/an/an/an/a



GALDERMA RESEARCH & DEVELOPMENT

US Patent


Assay Description
The RORγ transactivation model was developed from the line HG5LN, which is a HeLa line that stably expresses a luciferase reporter gene controll...


US Patent US10457637 (2019)

More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma (RORC)


(Homo sapiens (Human))
BDBM419233
PNG
(N-(4-ethylphenyl)-N- isobutyl-3-(S- methylsulfonim...)
Show SMILES CCc1ccc(cc1)N(CC(C)C)S(=O)(=O)c1ccc(N2CC3(COC3)C2)c(c1)S(C)(=N)=O
Show InChI InChI=1/C24H33N3O4S2/c1-5-19-6-8-20(9-7-19)27(13-18(2)3)33(29,30)21-10-11-22(23(12-21)32(4,25)28)26-14-24(15-26)16-31-17-24/h6-12,18,25H,5,13-17H2,1-4H3
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n/an/a<100n/an/an/an/an/an/a



GALDERMA RESEARCH & DEVELOPMENT

US Patent


Assay Description
The RORγ transactivation model was developed from the line HG5LN, which is a HeLa line that stably expresses a luciferase reporter gene controll...


US Patent US10457637 (2019)

More data for this
Ligand-Target Pair
Interleukin-17A


(Homo sapiens (Human))
BDBM50461076
PNG
(CHEMBL4227214 | US10457637, Compound 124)
Show SMILES CCc1ccc(cc1)N(CC(C)C)S(=O)(=O)c1ccc(NCC2(CC)CCOCC2)c(c1)S(C)(=N)=O
Show InChI InChI=1S/C27H41N3O4S2/c1-6-22-8-10-23(11-9-22)30(19-21(3)4)36(32,33)24-12-13-25(26(18-24)35(5,28)31)29-20-27(7-2)14-16-34-17-15-27/h8-13,18,21,28-29H,6-7,14-17,19-20H2,1-5H3
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n/an/a<100n/an/an/an/an/an/a



GALDERMA RESEARCH & DEVELOPMENT

US Patent


Assay Description
This model allows measurement of the effect of inhibitors on IL-17A secretion by CD4+ cells. The cells are frozen CD4+ cells (STEMCELL, #70026), isol...


US Patent US10457637 (2019)

More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma (RORC)


(Homo sapiens (Human))
BDBM419252
PNG
(N-(4-ethylphenyl)-N- isobutyl-3-(S- methylsulfonim...)
Show SMILES CCc1ccc(cc1)N(CC(C)C)S(=O)(=O)c1ccc(NCc2ccncn2)c(c1)S(C)(=N)=O
Show InChI InChI=1/C24H31N5O3S2/c1-5-19-6-8-21(9-7-19)29(16-18(2)3)34(31,32)22-10-11-23(24(14-22)33(4,25)30)27-15-20-12-13-26-17-28-20/h6-14,17-18,25,27H,5,15-16H2,1-4H3
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n/an/a<100n/an/an/an/an/an/a



GALDERMA RESEARCH & DEVELOPMENT

US Patent


Assay Description
The RORγ transactivation model was developed from the line HG5LN, which is a HeLa line that stably expresses a luciferase reporter gene controll...


US Patent US10457637 (2019)

More data for this
Ligand-Target Pair
Interleukin-17A


(Homo sapiens (Human))
BDBM50461063
PNG
(CHEMBL4226803 | US10457637, Compound 8)
Show SMILES CCc1ccc(cc1)N(CC(C)C)S(=O)(=O)c1ccc(OCC2CCOCC2)c(c1)[S@@](C)(=N)=O
Show InChI InChI=1S/C25H36N2O5S2/c1-5-20-6-8-22(9-7-20)27(17-19(2)3)34(29,30)23-10-11-24(25(16-23)33(4,26)28)32-18-21-12-14-31-15-13-21/h6-11,16,19,21,26H,5,12-15,17-18H2,1-4H3/t33-/m0/s1
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n/an/a<100n/an/an/an/an/an/a



GALDERMA RESEARCH & DEVELOPMENT

US Patent


Assay Description
This model allows measurement of the effect of inhibitors on IL-17A secretion by CD4+ cells. The cells are frozen CD4+ cells (STEMCELL, #70026), isol...


US Patent US10457637 (2019)

More data for this
Ligand-Target Pair
Interleukin-17A


(Homo sapiens (Human))
BDBM419157
PNG
(N-(4-ethylphenyl)-3- hydroxymethyl-N-isobutyl- 4-(...)
Show SMILES CCc1ccc(cc1)N(CC(C)C)S(=O)(=O)c1ccc(SCC2CCOCC2)c(CO)c1
Show InChI InChI=1S/C25H35NO4S2/c1-4-20-5-7-23(8-6-20)26(16-19(2)3)32(28,29)24-9-10-25(22(15-24)17-27)31-18-21-11-13-30-14-12-21/h5-10,15,19,21,27H,4,11-14,16-18H2,1-3H3
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n/an/a<100n/an/an/an/an/an/a



GALDERMA RESEARCH & DEVELOPMENT

US Patent


Assay Description
This model allows measurement of the effect of inhibitors on IL-17A secretion by CD4+ cells. The cells are frozen CD4+ cells (STEMCELL, #70026), isol...


US Patent US10457637 (2019)

More data for this
Ligand-Target Pair
Interleukin-17A


(Homo sapiens (Human))
BDBM419162
PNG
(N-(4-ethylphenyl)-4-((4- fluorotetrahydro-2H-pyran...)
Show SMILES CCc1ccc(cc1)N(CC(C)C)S(=O)(=O)c1ccc(OCC2(F)CCOCC2)c(c1)S(C)(=N)=O
Show InChI InChI=1/C25H35FN2O5S2/c1-5-20-6-8-21(9-7-20)28(17-19(2)3)35(30,31)22-10-11-23(24(16-22)34(4,27)29)33-18-25(26)12-14-32-15-13-25/h6-11,16,19,27H,5,12-15,17-18H2,1-4H3
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n/an/a<100n/an/an/an/an/an/a



GALDERMA RESEARCH & DEVELOPMENT

US Patent


Assay Description
This model allows measurement of the effect of inhibitors on IL-17A secretion by CD4+ cells. The cells are frozen CD4+ cells (STEMCELL, #70026), isol...


US Patent US10457637 (2019)

More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma (RORC)


(Homo sapiens (Human))
BDBM50461069
PNG
(CHEMBL4228522 | US10457637, Compound 66)
Show SMILES CCc1ccc(cc1)N(CC(C)C)S(=O)(=O)c1ccc(OCC2CCOCC2)c(c1)S(N)(=O)=O
Show InChI InChI=1S/C24H34N2O6S2/c1-4-19-5-7-21(8-6-19)26(16-18(2)3)34(29,30)22-9-10-23(24(15-22)33(25,27)28)32-17-20-11-13-31-14-12-20/h5-10,15,18,20H,4,11-14,16-17H2,1-3H3,(H2,25,27,28)
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n/an/a<100n/an/an/an/an/an/a



GALDERMA RESEARCH & DEVELOPMENT

US Patent


Assay Description
The RORγ transactivation model was developed from the line HG5LN, which is a HeLa line that stably expresses a luciferase reporter gene controll...


US Patent US10457637 (2019)

More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma (RORC)


(Homo sapiens (Human))
BDBM50461065
PNG
(CHEMBL4225020 | US10457637, Compound 18)
Show SMILES CCc1ccc(cc1)N(CC(C)C)S(=O)(=O)c1ccc(OCC2CCOCC2)c(c1)S(=N)(=O)CC
Show InChI InChI=1S/C26H38N2O5S2/c1-5-21-7-9-23(10-8-21)28(18-20(3)4)35(30,31)24-11-12-25(26(17-24)34(27,29)6-2)33-19-22-13-15-32-16-14-22/h7-12,17,20,22,27H,5-6,13-16,18-19H2,1-4H3
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n/an/a<100n/an/an/an/an/an/a



GALDERMA RESEARCH & DEVELOPMENT

US Patent


Assay Description
The RORγ transactivation model was developed from the line HG5LN, which is a HeLa line that stably expresses a luciferase reporter gene controll...


US Patent US10457637 (2019)

More data for this
Ligand-Target Pair
Interleukin-17A


(Homo sapiens (Human))
BDBM50461074
PNG
(CHEMBL4227729 | US10457637, Compound 52)
Show SMILES CCc1ccc(cc1)N(CC(C)C)S(=O)(=O)c1ccc(NCC2CCOCC2)c(c1)S(C)(=N)=O
Show InChI InChI=1S/C25H37N3O4S2/c1-5-20-6-8-22(9-7-20)28(18-19(2)3)34(30,31)23-10-11-24(25(16-23)33(4,26)29)27-17-21-12-14-32-15-13-21/h6-11,16,19,21,26-27H,5,12-15,17-18H2,1-4H3
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n/an/a<100n/an/an/an/an/an/a



GALDERMA RESEARCH & DEVELOPMENT

US Patent


Assay Description
This model allows measurement of the effect of inhibitors on IL-17A secretion by CD4+ cells. The cells are frozen CD4+ cells (STEMCELL, #70026), isol...


US Patent US10457637 (2019)

More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma (RORC)


(Homo sapiens (Human))
BDBM419189
PNG
(N-(4-ethylphenyl)-4-(((3- hydroxycyclobutyl)methyl...)
Show SMILES CCc1ccc(cc1)N(CC(C)C)S(=O)(=O)c1ccc(NCC2CC(O)C2)c(c1)S(C)(=N)=O
Show InChI InChI=1/C24H35N3O4S2/c1-5-18-6-8-20(9-7-18)27(16-17(2)3)33(30,31)22-10-11-23(24(14-22)32(4,25)29)26-15-19-12-21(28)13-19/h6-11,14,17,19,21,25-26,28H,5,12-13,15-16H2,1-4H3
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n/an/a<100n/an/an/an/an/an/a



GALDERMA RESEARCH & DEVELOPMENT

US Patent


Assay Description
The RORγ transactivation model was developed from the line HG5LN, which is a HeLa line that stably expresses a luciferase reporter gene controll...


US Patent US10457637 (2019)

More data for this
Ligand-Target Pair
Interleukin-17A


(Homo sapiens (Human))
BDBM419189
PNG
(N-(4-ethylphenyl)-4-(((3- hydroxycyclobutyl)methyl...)
Show SMILES CCc1ccc(cc1)N(CC(C)C)S(=O)(=O)c1ccc(NCC2CC(O)C2)c(c1)S(C)(=N)=O
Show InChI InChI=1/C24H35N3O4S2/c1-5-18-6-8-20(9-7-18)27(16-17(2)3)33(30,31)22-10-11-23(24(14-22)32(4,25)29)26-15-19-12-21(28)13-19/h6-11,14,17,19,21,25-26,28H,5,12-13,15-16H2,1-4H3
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n/an/a<100n/an/an/an/an/an/a



GALDERMA RESEARCH & DEVELOPMENT

US Patent


Assay Description
This model allows measurement of the effect of inhibitors on IL-17A secretion by CD4+ cells. The cells are frozen CD4+ cells (STEMCELL, #70026), isol...


US Patent US10457637 (2019)

More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma (RORC)


(Homo sapiens (Human))
BDBM419256
PNG
(N-(2,4-dimethylphenyl)-N- isobutyl-3-(S- methylsul...)
Show SMILES CC(C)CN(c1ccc(C)cc1C)S(=O)(=O)c1ccc(OCC2CCOCC2)c(c1)S(C)(=N)=O
Show InChI InChI=1/C25H36N2O5S2/c1-18(2)16-27(23-8-6-19(3)14-20(23)4)34(29,30)22-7-9-24(25(15-22)33(5,26)28)32-17-21-10-12-31-13-11-21/h6-9,14-15,18,21,26H,10-13,16-17H2,1-5H3
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n/an/a<100n/an/an/an/an/an/a



GALDERMA RESEARCH & DEVELOPMENT

US Patent


Assay Description
The RORγ transactivation model was developed from the line HG5LN, which is a HeLa line that stably expresses a luciferase reporter gene controll...


US Patent US10457637 (2019)

More data for this
Ligand-Target Pair
Interleukin-17A


(Homo sapiens (Human))
BDBM419154
PNG
(N-(4-ethylphenyl)-N- isobutyl-3-methanesulfinyl- 4...)
Show SMILES CCc1ccc(cc1)N(CC(C)C)S(=O)(=O)c1ccc(OCC2CCOCC2)c(c1)S(C)=O
Show InChI InChI=1/C25H35NO5S2/c1-5-20-6-8-22(9-7-20)26(17-19(2)3)33(28,29)23-10-11-24(25(16-23)32(4)27)31-18-21-12-14-30-15-13-21/h6-11,16,19,21H,5,12-15,17-18H2,1-4H3
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n/an/a<100n/an/an/an/an/an/a



GALDERMA RESEARCH & DEVELOPMENT

US Patent


Assay Description
This model allows measurement of the effect of inhibitors on IL-17A secretion by CD4+ cells. The cells are frozen CD4+ cells (STEMCELL, #70026), isol...


US Patent US10457637 (2019)

More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma (RORC)


(Homo sapiens (Human))
BDBM419163
PNG
(4-((3- oxabicyclo[3.1.0]hexan-6- yl)methoxy)-N-(4-...)
Show SMILES CCc1ccc(cc1)N(CC(C)C)S(=O)(=O)c1ccc(OCC2C3COCC23)c(c1)S(C)(=N)=O
Show InChI InChI=1/C25H34N2O5S2/c1-5-18-6-8-19(9-7-18)27(13-17(2)3)34(29,30)20-10-11-24(25(12-20)33(4,26)28)32-16-23-21-14-31-15-22(21)23/h6-12,17,21-23,26H,5,13-16H2,1-4H3
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n/an/a<100n/an/an/an/an/an/a



GALDERMA RESEARCH & DEVELOPMENT

US Patent


Assay Description
The RORγ transactivation model was developed from the line HG5LN, which is a HeLa line that stably expresses a luciferase reporter gene controll...


US Patent US10457637 (2019)

More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma (RORC)


(Homo sapiens (Human))
BDBM419167
PNG
(4-(((1R,5S,6R)-3- oxabicyclo[3.1.0]hexan-6- yl)met...)
Show SMILES CCc1ccc(cc1)N(CC(C)C)S(=O)(=O)c1ccc(OC[C@H]2[C@@H]3COC[C@H]23)c(c1)S(C)(=N)=O
Show InChI InChI=1/C25H34N2O5S2/c1-5-18-6-8-19(9-7-18)27(13-17(2)3)34(29,30)20-10-11-24(25(12-20)33(4,26)28)32-16-23-21-14-31-15-22(21)23/h6-12,17,21-23,26H,5,13-16H2,1-4H3/t21-,22+,23+,33?
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n/an/a<100n/an/an/an/an/an/a



GALDERMA RESEARCH & DEVELOPMENT

US Patent


Assay Description
The RORγ transactivation model was developed from the line HG5LN, which is a HeLa line that stably expresses a luciferase reporter gene controll...


US Patent US10457637 (2019)

More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma (RORC)


(Homo sapiens (Human))
BDBM50461066
PNG
(CHEMBL4228566 | US10457637, Compound 53)
Show SMILES CCc1ccc(cc1)N(CC(C)C)S(=O)(=O)c1ccc(N(C)CC2CCOCC2)c(c1)S(C)(=N)=O
Show InChI InChI=1S/C26H39N3O4S2/c1-6-21-7-9-23(10-8-21)29(18-20(2)3)35(31,32)24-11-12-25(26(17-24)34(5,27)30)28(4)19-22-13-15-33-16-14-22/h7-12,17,20,22,27H,6,13-16,18-19H2,1-5H3
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n/an/a<100n/an/an/an/an/an/a



GALDERMA RESEARCH & DEVELOPMENT

US Patent


Assay Description
The RORγ transactivation model was developed from the line HG5LN, which is a HeLa line that stably expresses a luciferase reporter gene controll...


US Patent US10457637 (2019)

More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma (RORC)


(Homo sapiens (Human))
BDBM50461075
PNG
(CHEMBL4225072 | US10457637, Compound 55)
Show SMILES CCc1ccc(cc1)N(CC(C)C)S(=O)(=O)c1ccc(NCC2(C)CCOCC2)c(c1)S(C)(=N)=O
Show InChI InChI=1S/C26H39N3O4S2/c1-6-21-7-9-22(10-8-21)29(18-20(2)3)35(31,32)23-11-12-24(25(17-23)34(5,27)30)28-19-26(4)13-15-33-16-14-26/h7-12,17,20,27-28H,6,13-16,18-19H2,1-5H3
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n/an/a<100n/an/an/an/an/an/a



GALDERMA RESEARCH & DEVELOPMENT

US Patent


Assay Description
The RORγ transactivation model was developed from the line HG5LN, which is a HeLa line that stably expresses a luciferase reporter gene controll...


US Patent US10457637 (2019)

More data for this
Ligand-Target Pair
Interleukin-17A


(Homo sapiens (Human))
BDBM419192
PNG
(N-(4-ethylphenyl)-N- isobutyl-3-(S- methylsulfonim...)
Show SMILES CCc1ccc(cc1)N(CC(C)C)S(=O)(=O)c1ccc(NCc2ccncc2)c(c1)S(C)(=N)=O
Show InChI InChI=1/C25H32N4O3S2/c1-5-20-6-8-22(9-7-20)29(18-19(2)3)34(31,32)23-10-11-24(25(16-23)33(4,26)30)28-17-21-12-14-27-15-13-21/h6-16,19,26,28H,5,17-18H2,1-4H3
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n/an/a<100n/an/an/an/an/an/a



GALDERMA RESEARCH & DEVELOPMENT

US Patent


Assay Description
This model allows measurement of the effect of inhibitors on IL-17A secretion by CD4+ cells. The cells are frozen CD4+ cells (STEMCELL, #70026), isol...


US Patent US10457637 (2019)

More data for this
Ligand-Target Pair
Interleukin-17A


(Homo sapiens (Human))
BDBM419252
PNG
(N-(4-ethylphenyl)-N- isobutyl-3-(S- methylsulfonim...)
Show SMILES CCc1ccc(cc1)N(CC(C)C)S(=O)(=O)c1ccc(NCc2ccncn2)c(c1)S(C)(=N)=O
Show InChI InChI=1/C24H31N5O3S2/c1-5-19-6-8-21(9-7-19)29(16-18(2)3)34(31,32)22-10-11-23(24(14-22)33(4,25)30)27-15-20-12-13-26-17-28-20/h6-14,17-18,25,27H,5,15-16H2,1-4H3
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n/an/a<100n/an/an/an/an/an/a



GALDERMA RESEARCH & DEVELOPMENT

US Patent


Assay Description
This model allows measurement of the effect of inhibitors on IL-17A secretion by CD4+ cells. The cells are frozen CD4+ cells (STEMCELL, #70026), isol...


US Patent US10457637 (2019)

More data for this
Ligand-Target Pair
Interleukin-17A


(Homo sapiens (Human))
BDBM419256
PNG
(N-(2,4-dimethylphenyl)-N- isobutyl-3-(S- methylsul...)
Show SMILES CC(C)CN(c1ccc(C)cc1C)S(=O)(=O)c1ccc(OCC2CCOCC2)c(c1)S(C)(=N)=O
Show InChI InChI=1/C25H36N2O5S2/c1-18(2)16-27(23-8-6-19(3)14-20(23)4)34(29,30)22-7-9-24(25(15-22)33(5,26)28)32-17-21-10-12-31-13-11-21/h6-9,14-15,18,21,26H,10-13,16-17H2,1-5H3
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n/an/a<100n/an/an/an/an/an/a



GALDERMA RESEARCH & DEVELOPMENT

US Patent


Assay Description
This model allows measurement of the effect of inhibitors on IL-17A secretion by CD4+ cells. The cells are frozen CD4+ cells (STEMCELL, #70026), isol...


US Patent US10457637 (2019)

More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma (RORC)


(Homo sapiens (Human))
BDBM419139
PNG
(BDBM50461078 | N-(4-ethylphenyl)-N- isobutyl-3- me...)
Show SMILES CCc1ccc(cc1)N(CC(C)C)S(=O)(=O)c1ccc(OCC2CCOCC2)c(c1)S(C)(N)=O
Show InChI InChI=1S/C25H38N2O5S2/c1-5-20-6-8-22(9-7-20)27(17-19(2)3)34(29,30)23-10-11-24(25(16-23)33(4,26)28)32-18-21-12-14-31-15-13-21/h6-11,16,19,21,33H,5,12-15,17-18H2,1-4H3,(H2,26,28)
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n/an/a<100n/an/an/an/an/an/a



GALDERMA RESEARCH & DEVELOPMENT

US Patent


Assay Description
The RORγ transactivation model was developed from the line HG5LN, which is a HeLa line that stably expresses a luciferase reporter gene controll...


US Patent US10457637 (2019)

More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma (RORC)


(Homo sapiens (Human))
BDBM50461063
PNG
(CHEMBL4226803 | US10457637, Compound 8)
Show SMILES CCc1ccc(cc1)N(CC(C)C)S(=O)(=O)c1ccc(OCC2CCOCC2)c(c1)[S@@](C)(=N)=O
Show InChI InChI=1S/C25H36N2O5S2/c1-5-20-6-8-22(9-7-20)27(17-19(2)3)34(29,30)23-10-11-24(25(16-23)33(4,26)28)32-18-21-12-14-31-15-13-21/h6-11,16,19,21,26H,5,12-15,17-18H2,1-4H3/t33-/m0/s1
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n/an/a<100n/an/an/an/an/an/a



GALDERMA RESEARCH & DEVELOPMENT

US Patent


Assay Description
The RORγ transactivation model was developed from the line HG5LN, which is a HeLa line that stably expresses a luciferase reporter gene controll...


US Patent US10457637 (2019)

More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma (RORC)


(Homo sapiens (Human))
BDBM419154
PNG
(N-(4-ethylphenyl)-N- isobutyl-3-methanesulfinyl- 4...)
Show SMILES CCc1ccc(cc1)N(CC(C)C)S(=O)(=O)c1ccc(OCC2CCOCC2)c(c1)S(C)=O
Show InChI InChI=1/C25H35NO5S2/c1-5-20-6-8-22(9-7-20)26(17-19(2)3)33(28,29)23-10-11-24(25(16-23)32(4)27)31-18-21-12-14-30-15-13-21/h6-11,16,19,21H,5,12-15,17-18H2,1-4H3
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n/an/a<100n/an/an/an/an/an/a



GALDERMA RESEARCH & DEVELOPMENT

US Patent


Assay Description
The RORγ transactivation model was developed from the line HG5LN, which is a HeLa line that stably expresses a luciferase reporter gene controll...


US Patent US10457637 (2019)

More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma (RORC)


(Homo sapiens (Human))
BDBM419162
PNG
(N-(4-ethylphenyl)-4-((4- fluorotetrahydro-2H-pyran...)
Show SMILES CCc1ccc(cc1)N(CC(C)C)S(=O)(=O)c1ccc(OCC2(F)CCOCC2)c(c1)S(C)(=N)=O
Show InChI InChI=1/C25H35FN2O5S2/c1-5-20-6-8-21(9-7-20)28(17-19(2)3)35(30,31)22-10-11-23(24(16-22)34(4,27)29)33-18-25(26)12-14-32-15-13-25/h6-11,16,19,27H,5,12-15,17-18H2,1-4H3
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n/an/a<100n/an/an/an/an/an/a



GALDERMA RESEARCH & DEVELOPMENT

US Patent


Assay Description
The RORγ transactivation model was developed from the line HG5LN, which is a HeLa line that stably expresses a luciferase reporter gene controll...


US Patent US10457637 (2019)

More data for this
Ligand-Target Pair
Interleukin-17A


(Homo sapiens (Human))
BDBM50461075
PNG
(CHEMBL4225072 | US10457637, Compound 55)
Show SMILES CCc1ccc(cc1)N(CC(C)C)S(=O)(=O)c1ccc(NCC2(C)CCOCC2)c(c1)S(C)(=N)=O
Show InChI InChI=1S/C26H39N3O4S2/c1-6-21-7-9-22(10-8-21)29(18-20(2)3)35(31,32)23-11-12-24(25(17-23)34(5,27)30)28-19-26(4)13-15-33-16-14-26/h7-12,17,20,27-28H,6,13-16,18-19H2,1-5H3
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n/an/a<100n/an/an/an/an/an/a



GALDERMA RESEARCH & DEVELOPMENT

US Patent


Assay Description
This model allows measurement of the effect of inhibitors on IL-17A secretion by CD4+ cells. The cells are frozen CD4+ cells (STEMCELL, #70026), isol...


US Patent US10457637 (2019)

More data for this
Ligand-Target Pair
Interleukin-17A


(Homo sapiens (Human))
BDBM419218
PNG
(4-((((1R,5S,6S)-3- oxabicyclo[3.1.0]hexan-6- yl)me...)
Show SMILES CCc1ccc(cc1)N(CC(C)C)S(=O)(=O)c1ccc(NC[C@H]2[C@@H]3COC[C@H]23)c(c1)S(C)(=N)=O
Show InChI InChI=1/C25H35N3O4S2/c1-5-18-6-8-19(9-7-18)28(14-17(2)3)34(30,31)20-10-11-24(25(12-20)33(4,26)29)27-13-21-22-15-32-16-23(21)22/h6-12,17,21-23,26-27H,5,13-16H2,1-4H3/t21-,22-,23+,33?
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n/an/a<100n/an/an/an/an/an/a



GALDERMA RESEARCH & DEVELOPMENT

US Patent


Assay Description
This model allows measurement of the effect of inhibitors on IL-17A secretion by CD4+ cells. The cells are frozen CD4+ cells (STEMCELL, #70026), isol...


US Patent US10457637 (2019)

More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma (RORC)


(Homo sapiens (Human))
BDBM419148
PNG
(N-(4-ethylphenyl)-N- isobutyl-4-(tetrahydropyran- ...)
Show SMILES CCc1ccc(cc1)N(CC(C)C)S(=O)(=O)c1ccc(cc1)S(=O)CC1CCOCC1
Show InChI InChI=1/C24H33NO4S2/c1-4-20-5-7-22(8-6-20)25(17-19(2)3)31(27,28)24-11-9-23(10-12-24)30(26)18-21-13-15-29-16-14-21/h5-12,19,21H,4,13-18H2,1-3H3
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n/an/a 550n/an/an/an/an/an/a



GALDERMA RESEARCH & DEVELOPMENT

US Patent


Assay Description
The RORγ transactivation model was developed from the line HG5LN, which is a HeLa line that stably expresses a luciferase reporter gene controll...


US Patent US10457637 (2019)

More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma (RORC)


(Homo sapiens (Human))
BDBM419157
PNG
(N-(4-ethylphenyl)-3- hydroxymethyl-N-isobutyl- 4-(...)
Show SMILES CCc1ccc(cc1)N(CC(C)C)S(=O)(=O)c1ccc(SCC2CCOCC2)c(CO)c1
Show InChI InChI=1S/C25H35NO4S2/c1-4-20-5-7-23(8-6-20)26(16-19(2)3)32(28,29)24-9-10-25(22(15-24)17-27)31-18-21-11-13-30-14-12-21/h5-10,15,19,21,27H,4,11-14,16-18H2,1-3H3
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n/an/a 550n/an/an/an/an/an/a



GALDERMA RESEARCH & DEVELOPMENT

US Patent


Assay Description
The RORγ transactivation model was developed from the line HG5LN, which is a HeLa line that stably expresses a luciferase reporter gene controll...


US Patent US10457637 (2019)

More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma (RORC)


(Homo sapiens (Human))
BDBM50461082
PNG
(CHEMBL4226691 | US10457637, Compound 63)
Show SMILES CCc1ccc(cc1)N(CC(C)C)S(=O)(=O)c1ccc(N2CCN(CC2)C(C)=O)c(c1)S(C)(=N)=O
Show InChI InChI=1S/C25H36N4O4S2/c1-6-21-7-9-22(10-8-21)29(18-19(2)3)35(32,33)23-11-12-24(25(17-23)34(5,26)31)28-15-13-27(14-16-28)20(4)30/h7-12,17,19,26H,6,13-16,18H2,1-5H3
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n/an/a 550n/an/an/an/an/an/a



GALDERMA RESEARCH & DEVELOPMENT

US Patent


Assay Description
The RORγ transactivation model was developed from the line HG5LN, which is a HeLa line that stably expresses a luciferase reporter gene controll...


US Patent US10457637 (2019)

More data for this
Ligand-Target Pair
Interleukin-17A


(Homo sapiens (Human))
BDBM419257
PNG
(N-isopropyl-N-(4-methoxy- 2-methylphenyl)-3-(S- me...)
Show SMILES COc1ccc(N(C(C)C)S(=O)(=O)c2ccc(OCC3CCOCC3)c(c2)S(C)(=N)=O)c(C)c1
Show InChI InChI=1/C24H34N2O6S2/c1-17(2)26(22-8-6-20(30-4)14-18(22)3)34(28,29)21-7-9-23(24(15-21)33(5,25)27)32-16-19-10-12-31-13-11-19/h6-9,14-15,17,19,25H,10-13,16H2,1-5H3
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n/an/a 550n/an/an/an/an/an/a



GALDERMA RESEARCH & DEVELOPMENT

US Patent


Assay Description
This model allows measurement of the effect of inhibitors on IL-17A secretion by CD4+ cells. The cells are frozen CD4+ cells (STEMCELL, #70026), isol...


US Patent US10457637 (2019)

More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma (RORC)


(Homo sapiens (Human))
BDBM419158
PNG
(US10457637, Compound 22 | ethanesulfinyl-N-(4- eth...)
Show SMILES CCc1ccc(cc1)N(CC(C)C)S(=O)(=O)c1ccc(OCC2CCOCC2)c(c1)S(=O)CC
Show InChI InChI=1/C26H37NO5S2/c1-5-21-7-9-23(10-8-21)27(18-20(3)4)34(29,30)24-11-12-25(26(17-24)33(28)6-2)32-19-22-13-15-31-16-14-22/h7-12,17,20,22H,5-6,13-16,18-19H2,1-4H3
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n/an/a 550n/an/an/an/an/an/a



GALDERMA RESEARCH & DEVELOPMENT

US Patent


Assay Description
The RORγ transactivation model was developed from the line HG5LN, which is a HeLa line that stably expresses a luciferase reporter gene controll...


US Patent US10457637 (2019)

More data for this
Ligand-Target Pair
Interleukin-17A


(Homo sapiens (Human))
BDBM419148
PNG
(N-(4-ethylphenyl)-N- isobutyl-4-(tetrahydropyran- ...)
Show SMILES CCc1ccc(cc1)N(CC(C)C)S(=O)(=O)c1ccc(cc1)S(=O)CC1CCOCC1
Show InChI InChI=1/C24H33NO4S2/c1-4-20-5-7-22(8-6-20)25(17-19(2)3)31(27,28)24-11-9-23(10-12-24)30(26)18-21-13-15-29-16-14-21/h5-12,19,21H,4,13-18H2,1-3H3
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n/an/a 550n/an/an/an/an/an/a



GALDERMA RESEARCH & DEVELOPMENT

US Patent


Assay Description
This model allows measurement of the effect of inhibitors on IL-17A secretion by CD4+ cells. The cells are frozen CD4+ cells (STEMCELL, #70026), isol...


US Patent US10457637 (2019)

More data for this
Ligand-Target Pair
Interleukin-17A


(Homo sapiens (Human))
BDBM419148
PNG
(N-(4-ethylphenyl)-N- isobutyl-4-(tetrahydropyran- ...)
Show SMILES CCc1ccc(cc1)N(CC(C)C)S(=O)(=O)c1ccc(cc1)S(=O)CC1CCOCC1
Show InChI InChI=1/C24H33NO4S2/c1-4-20-5-7-22(8-6-20)25(17-19(2)3)31(27,28)24-11-9-23(10-12-24)30(26)18-21-13-15-29-16-14-21/h5-12,19,21H,4,13-18H2,1-3H3
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n/an/a 550n/an/an/an/an/an/a



GALDERMA RESEARCH & DEVELOPMENT

US Patent


Assay Description
This model allows measurement of the effect of inhibitors on IL-17A secretion by CD4+ cells. The cells are frozen CD4+ cells (STEMCELL, #70026), isol...


US Patent US10457637 (2019)

More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma (RORC)


(Homo sapiens (Human))
BDBM419147
PNG
(N-(4-ethylphenyl)-N- isobutyl-4-(tetrahydropyran- ...)
Show SMILES CCc1ccc(cc1)N(CC(C)C)S(=O)(=O)c1ccc(cc1)S(=O)CC1CCOCC1
Show InChI InChI=1/C24H33NO4S2/c1-4-20-5-7-22(8-6-20)25(17-19(2)3)31(27,28)24-11-9-23(10-12-24)30(26)18-21-13-15-29-16-14-21/h5-12,19,21H,4,13-18H2,1-3H3
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n/an/a 550n/an/an/an/an/an/a



GALDERMA RESEARCH & DEVELOPMENT

US Patent


Assay Description
The RORγ transactivation model was developed from the line HG5LN, which is a HeLa line that stably expresses a luciferase reporter gene controll...


US Patent US10457637 (2019)

More data for this
Ligand-Target Pair
Interleukin-17A


(Homo sapiens (Human))
BDBM419160
PNG
(N-(4-ethylphenyl)-N- isobutyl-3-methylsulfanyl-4- ...)
Show SMILES CCc1ccc(cc1)N(CC(C)C)S(=O)(=O)c1ccc(OCC2CCOCC2)c(SC)c1
Show InChI InChI=1S/C25H35NO4S2/c1-5-20-6-8-22(9-7-20)26(17-19(2)3)32(27,28)23-10-11-24(25(16-23)31-4)30-18-21-12-14-29-15-13-21/h6-11,16,19,21H,5,12-15,17-18H2,1-4H3
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n/an/a 550n/an/an/an/an/an/a



GALDERMA RESEARCH & DEVELOPMENT

US Patent


Assay Description
This model allows measurement of the effect of inhibitors on IL-17A secretion by CD4+ cells. The cells are frozen CD4+ cells (STEMCELL, #70026), isol...


US Patent US10457637 (2019)

More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma (RORC)


(Homo sapiens (Human))
BDBM419195
PNG
(4-[(tetrahydropyran-4- ylmethyl)amino]benzene- 1,3...)
Show SMILES CCc1ccc(cc1)N(CC(C)C)S(=O)(=O)c1ccc(NCC2CCOCC2)c(c1)S(N)(=O)=O
Show InChI InChI=1S/C24H35N3O5S2/c1-4-19-5-7-21(8-6-19)27(17-18(2)3)34(30,31)22-9-10-23(24(15-22)33(25,28)29)26-16-20-11-13-32-14-12-20/h5-10,15,18,20,26H,4,11-14,16-17H2,1-3H3,(H2,25,28,29)
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n/an/a 550n/an/an/an/an/an/a



GALDERMA RESEARCH & DEVELOPMENT

US Patent


Assay Description
The RORγ transactivation model was developed from the line HG5LN, which is a HeLa line that stably expresses a luciferase reporter gene controll...


US Patent US10457637 (2019)

More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma (RORC)


(Homo sapiens (Human))
BDBM419209
PNG
(N-(4-ethylphenyl)-N- isobutyl-3-(S- methylsulfonim...)
Show SMILES CCc1ccc(cc1)N(CC(C)C)S(=O)(=O)c1ccc(NCC2CNC(=O)O2)c(c1)S(C)(=N)=O
Show InChI InChI=1/C23H32N4O5S2/c1-5-17-6-8-18(9-7-17)27(15-16(2)3)34(30,31)20-10-11-21(22(12-20)33(4,24)29)25-13-19-14-26-23(28)32-19/h6-12,16,19,24-25H,5,13-15H2,1-4H3,(H,26,28)
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n/an/a 550n/an/an/an/an/an/a



GALDERMA RESEARCH & DEVELOPMENT

US Patent


Assay Description
The RORγ transactivation model was developed from the line HG5LN, which is a HeLa line that stably expresses a luciferase reporter gene controll...


US Patent US10457637 (2019)

More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma (RORC)


(Homo sapiens (Human))
BDBM419222
PNG
(4-(((2-oxaspiro[3.3]heptan- 6-yl)methyl)amino)-N-(...)
Show SMILES CCc1ccc(cc1)N(CC(C)C)S(=O)(=O)c1ccc(NCC2CC3(COC3)C2)c(c1)S(C)(=N)=O
Show InChI InChI=1/C26H37N3O4S2/c1-5-20-6-8-22(9-7-20)29(16-19(2)3)35(31,32)23-10-11-24(25(12-23)34(4,27)30)28-15-21-13-26(14-21)17-33-18-26/h6-12,19,21,27-28H,5,13-18H2,1-4H3
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n/an/a 550n/an/an/an/an/an/a



GALDERMA RESEARCH & DEVELOPMENT

US Patent


Assay Description
The RORγ transactivation model was developed from the line HG5LN, which is a HeLa line that stably expresses a luciferase reporter gene controll...


US Patent US10457637 (2019)

More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma (RORC)


(Homo sapiens (Human))
BDBM419237
PNG
(4-((1R,4R)-2-oxa-5- azabicyclo[2.2.1]heptan-5- yl)...)
Show SMILES CCc1ccc(cc1)N(CC(C)C)S(=O)(=O)c1ccc(N2C[C@H]3C[C@@H]2CO3)c(c1)S(C)(=N)=O
Show InChI InChI=1/C24H33N3O4S2/c1-5-18-6-8-19(9-7-18)27(14-17(2)3)33(29,30)22-10-11-23(24(13-22)32(4,25)28)26-15-21-12-20(26)16-31-21/h6-11,13,17,20-21,25H,5,12,14-16H2,1-4H3/t20-,21-,32?/s2
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n/an/a 550n/an/an/an/an/an/a



GALDERMA RESEARCH & DEVELOPMENT

US Patent


Assay Description
The RORγ transactivation model was developed from the line HG5LN, which is a HeLa line that stably expresses a luciferase reporter gene controll...


US Patent US10457637 (2019)

More data for this
Ligand-Target Pair
Interleukin-17A


(Homo sapiens (Human))
BDBM419156
PNG
(N-(4-ethylphenyl)-N- isobutyl-3-methanesulfinyl- 4...)
Show SMILES CCc1ccc(cc1)N(CC(C)C)S(=O)(=O)c1ccc(OCC2CCOCC2)c(c1)[S@](C)=O
Show InChI InChI=1/C25H35NO5S2/c1-5-20-6-8-22(9-7-20)26(17-19(2)3)33(28,29)23-10-11-24(25(16-23)32(4)27)31-18-21-12-14-30-15-13-21/h6-11,16,19,21H,5,12-15,17-18H2,1-4H3/t32-/s2
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n/an/a 550n/an/an/an/an/an/a



GALDERMA RESEARCH & DEVELOPMENT

US Patent


Assay Description
This model allows measurement of the effect of inhibitors on IL-17A secretion by CD4+ cells. The cells are frozen CD4+ cells (STEMCELL, #70026), isol...


US Patent US10457637 (2019)

More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma (RORC)


(Homo sapiens (Human))
BDBM50461068
PNG
(CHEMBL4228069 | US10457637, Compound 24)
Show SMILES CCc1ccc(cc1)N(CC(C)C)S(=O)(=O)c1ccc(OCC2CCOCC2)c(c1)S(C)(=O)=O
Show InChI InChI=1S/C25H35NO6S2/c1-5-20-6-8-22(9-7-20)26(17-19(2)3)34(29,30)23-10-11-24(25(16-23)33(4,27)28)32-18-21-12-14-31-15-13-21/h6-11,16,19,21H,5,12-15,17-18H2,1-4H3
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n/an/a 550n/an/an/an/an/an/a



GALDERMA RESEARCH & DEVELOPMENT

US Patent


Assay Description
The RORγ transactivation model was developed from the line HG5LN, which is a HeLa line that stably expresses a luciferase reporter gene controll...


US Patent US10457637 (2019)

More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma (RORC)


(Homo sapiens (Human))
BDBM419160
PNG
(N-(4-ethylphenyl)-N- isobutyl-3-methylsulfanyl-4- ...)
Show SMILES CCc1ccc(cc1)N(CC(C)C)S(=O)(=O)c1ccc(OCC2CCOCC2)c(SC)c1
Show InChI InChI=1S/C25H35NO4S2/c1-5-20-6-8-22(9-7-20)26(17-19(2)3)32(27,28)23-10-11-24(25(16-23)31-4)30-18-21-12-14-29-15-13-21/h6-11,16,19,21H,5,12-15,17-18H2,1-4H3
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n/an/a 550n/an/an/an/an/an/a



GALDERMA RESEARCH & DEVELOPMENT

US Patent


Assay Description
The RORγ transactivation model was developed from the line HG5LN, which is a HeLa line that stably expresses a luciferase reporter gene controll...


US Patent US10457637 (2019)

More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma (RORC)


(Homo sapiens (Human))
BDBM419187
PNG
(N-(4-ethylphenyl)-N- isobutyl-3-(S- methylsulfonim...)
Show SMILES CCc1ccc(cc1)N(CC(C)C)S(=O)(=O)c1ccc(NCC2CNC(=O)C2)c(c1)S(C)(=N)=O
Show InChI InChI=1/C24H34N4O4S2/c1-5-18-6-8-20(9-7-18)28(16-17(2)3)34(31,32)21-10-11-22(23(13-21)33(4,25)30)26-14-19-12-24(29)27-15-19/h6-11,13,17,19,25-26H,5,12,14-16H2,1-4H3,(H,27,29)
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n/an/a 550n/an/an/an/an/an/a



GALDERMA RESEARCH & DEVELOPMENT

US Patent


Assay Description
The RORγ transactivation model was developed from the line HG5LN, which is a HeLa line that stably expresses a luciferase reporter gene controll...


US Patent US10457637 (2019)

More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma (RORC)


(Homo sapiens (Human))
BDBM50461079
PNG
(CHEMBL4227543 | US10457637, Compound 65)
Show SMILES CCc1ccc(cc1)N(CC(C)C)S(=O)(=O)c1ccc(CCN2CCOCC2)c(c1)S(C)(=N)=O
Show InChI InChI=1S/C25H37N3O4S2/c1-5-21-6-9-23(10-7-21)28(19-20(2)3)34(30,31)24-11-8-22(25(18-24)33(4,26)29)12-13-27-14-16-32-17-15-27/h6-11,18,20,26H,5,12-17,19H2,1-4H3
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n/an/a 550n/an/an/an/an/an/a



GALDERMA RESEARCH & DEVELOPMENT

US Patent


Assay Description
The RORγ transactivation model was developed from the line HG5LN, which is a HeLa line that stably expresses a luciferase reporter gene controll...


US Patent US10457637 (2019)

More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma (RORC)


(Homo sapiens (Human))
BDBM419224
PNG
(4-(((3,5-dimethylisoxazol- 4-yl)methyl)amino)-N-(4...)
Show SMILES CCc1ccc(cc1)N(CC(C)C)S(=O)(=O)c1ccc(NCc2c(C)noc2C)c(c1)S(C)(=N)=O
Show InChI InChI=1/C25H34N4O4S2/c1-7-20-8-10-21(11-9-20)29(16-17(2)3)35(31,32)22-12-13-24(25(14-22)34(6,26)30)27-15-23-18(4)28-33-19(23)5/h8-14,17,26-27H,7,15-16H2,1-6H3
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n/an/a 550n/an/an/an/an/an/a



GALDERMA RESEARCH & DEVELOPMENT

US Patent


Assay Description
The RORγ transactivation model was developed from the line HG5LN, which is a HeLa line that stably expresses a luciferase reporter gene controll...


US Patent US10457637 (2019)

More data for this
Ligand-Target Pair
Interleukin-17A


(Homo sapiens (Human))
BDBM419235
PNG
(4-(2,2-dioxido-2-thia-6- azaspiro[3.3]heptan-6-yl)...)
Show SMILES CCc1ccc(cc1)N(CC(C)C)S(=O)(=O)c1ccc(N2CC3(C2)CS(=O)(=O)C3)c(c1)S(C)(=N)=O
Show InChI InChI=1/C24H33N3O5S3/c1-5-19-6-8-20(9-7-19)27(13-18(2)3)35(31,32)21-10-11-22(23(12-21)33(4,25)28)26-14-24(15-26)16-34(29,30)17-24/h6-12,18,25H,5,13-17H2,1-4H3
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n/an/a 550n/an/an/an/an/an/a



GALDERMA RESEARCH & DEVELOPMENT

US Patent


Assay Description
This model allows measurement of the effect of inhibitors on IL-17A secretion by CD4+ cells. The cells are frozen CD4+ cells (STEMCELL, #70026), isol...


US Patent US10457637 (2019)

More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma (RORC)


(Homo sapiens (Human))
BDBM419246
PNG
(N-(4-ethylphenyl)-N- isobutyl-4-(((2- methoxypyrid...)
Show SMILES CCc1ccc(cc1)N(CC(C)C)S(=O)(=O)c1ccc(NCc2ccnc(OC)c2)c(c1)S(C)(=N)=O
Show InChI InChI=1/C26H34N4O4S2/c1-6-20-7-9-22(10-8-20)30(18-19(2)3)36(32,33)23-11-12-24(25(16-23)35(5,27)31)29-17-21-13-14-28-26(15-21)34-4/h7-16,19,27,29H,6,17-18H2,1-5H3
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n/an/a 550n/an/an/an/an/an/a



GALDERMA RESEARCH & DEVELOPMENT

US Patent


Assay Description
The RORγ transactivation model was developed from the line HG5LN, which is a HeLa line that stably expresses a luciferase reporter gene controll...


US Patent US10457637 (2019)

More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma (RORC)


(Homo sapiens (Human))
BDBM50461070
PNG
(CHEMBL4227173 | US10457637, Compound 2)
Show SMILES CCc1ccc(cc1)N(CC(C)C)S(=O)(=O)c1ccc(OCC2CCOCC2)c(c1)S(C)(=O)=NC
Show InChI InChI=1S/C26H38N2O5S2/c1-6-21-7-9-23(10-8-21)28(18-20(2)3)35(30,31)24-11-12-25(26(17-24)34(5,29)27-4)33-19-22-13-15-32-16-14-22/h7-12,17,20,22H,6,13-16,18-19H2,1-5H3
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n/an/a 550n/an/an/an/an/an/a



GALDERMA RESEARCH & DEVELOPMENT

US Patent


Assay Description
The RORγ transactivation model was developed from the line HG5LN, which is a HeLa line that stably expresses a luciferase reporter gene controll...


US Patent US10457637 (2019)

More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma (RORC)


(Homo sapiens (Human))
BDBM419145
PNG
(N-(4-ethylphenyl)-3- hydroxymethyl-N-isobutyl- 4-(...)
Show SMILES CCc1ccc(cc1)N(CC(C)C)S(=O)(=O)c1ccc(c(CO)c1)S(=O)CC1CCOCC1
Show InChI InChI=1/C25H35NO5S2/c1-4-20-5-7-23(8-6-20)26(16-19(2)3)33(29,30)24-9-10-25(22(15-24)17-27)32(28)18-21-11-13-31-14-12-21/h5-10,15,19,21,27H,4,11-14,16-18H2,1-3H3
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n/an/a 550n/an/an/an/an/an/a



GALDERMA RESEARCH & DEVELOPMENT

US Patent


Assay Description
The RORγ transactivation model was developed from the line HG5LN, which is a HeLa line that stably expresses a luciferase reporter gene controll...


US Patent US10457637 (2019)

More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma (RORC)


(Homo sapiens (Human))
BDBM419145
PNG
(N-(4-ethylphenyl)-3- hydroxymethyl-N-isobutyl- 4-(...)
Show SMILES CCc1ccc(cc1)N(CC(C)C)S(=O)(=O)c1ccc(c(CO)c1)S(=O)CC1CCOCC1
Show InChI InChI=1/C25H35NO5S2/c1-4-20-5-7-23(8-6-20)26(16-19(2)3)33(29,30)24-9-10-25(22(15-24)17-27)32(28)18-21-11-13-31-14-12-21/h5-10,15,19,21,27H,4,11-14,16-18H2,1-3H3
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n/an/a 550n/an/an/an/an/an/a



GALDERMA RESEARCH & DEVELOPMENT

US Patent


Assay Description
The RORγ transactivation model was developed from the line HG5LN, which is a HeLa line that stably expresses a luciferase reporter gene controll...


US Patent US10457637 (2019)

More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma (RORC)


(Homo sapiens (Human))
BDBM419184
PNG
(N-(4-ethylphenyl)-N- isobutyl-3-(S- methylsulfonim...)
Show SMILES CCc1ccc(cc1)N(CC(C)C)S(=O)(=O)c1ccc(NCC2COC2)c(c1)S(C)(=N)=O
Show InChI InChI=1/C23H33N3O4S2/c1-5-18-6-8-20(9-7-18)26(14-17(2)3)32(28,29)21-10-11-22(23(12-21)31(4,24)27)25-13-19-15-30-16-19/h6-12,17,19,24-25H,5,13-16H2,1-4H3
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n/an/a 550n/an/an/an/an/an/a



GALDERMA RESEARCH & DEVELOPMENT

US Patent


Assay Description
The RORγ transactivation model was developed from the line HG5LN, which is a HeLa line that stably expresses a luciferase reporter gene controll...


US Patent US10457637 (2019)

More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma (RORC)


(Homo sapiens (Human))
BDBM50461077
PNG
(CHEMBL4228981 | US10457637, Compound 60)
Show SMILES CCc1ccc(cc1)N(CC(C)C)S(=O)(=O)c1ccc(N[C@H](C)C2CCOCC2)c(c1)S(C)(=N)=O
Show InChI InChI=1S/C26H39N3O4S2/c1-6-21-7-9-23(10-8-21)29(18-19(2)3)35(31,32)24-11-12-25(26(17-24)34(5,27)30)28-20(4)22-13-15-33-16-14-22/h7-12,17,19-20,22,27-28H,6,13-16,18H2,1-5H3/t20-,34?/m1/s1
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n/an/a 550n/an/an/an/an/an/a



GALDERMA RESEARCH & DEVELOPMENT

US Patent


Assay Description
The RORγ transactivation model was developed from the line HG5LN, which is a HeLa line that stably expresses a luciferase reporter gene controll...


US Patent US10457637 (2019)

More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma (RORC)


(Homo sapiens (Human))
BDBM50461088
PNG
(CHEMBL4227798 | US10457637, Compound 81)
Show SMILES CCc1ccc(cc1)N(CC(C)C)S(=O)(=O)c1ccc(N[C@@H](C)C2CCOCC2)c(c1)S(C)(=N)=O
Show InChI InChI=1S/C26H39N3O4S2/c1-6-21-7-9-23(10-8-21)29(18-19(2)3)35(31,32)24-11-12-25(26(17-24)34(5,27)30)28-20(4)22-13-15-33-16-14-22/h7-12,17,19-20,22,27-28H,6,13-16,18H2,1-5H3/t20-,34?/m0/s1
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n/an/a 550n/an/an/an/an/an/a



GALDERMA RESEARCH & DEVELOPMENT

US Patent


Assay Description
The RORγ transactivation model was developed from the line HG5LN, which is a HeLa line that stably expresses a luciferase reporter gene controll...


US Patent US10457637 (2019)

More data for this
Ligand-Target Pair
Interleukin-17A


(Homo sapiens (Human))
BDBM419236
PNG
(N-(4-ethylphenyl)-N- isobutyl-3-(S- methylsulfonim...)
Show SMILES CCc1ccc(cc1)N(CC(C)C)S(=O)(=O)c1ccc(N2CCC3(COC3)CC2)c(c1)S(C)(=N)=O
Show InChI InChI=1/C26H37N3O4S2/c1-5-21-6-8-22(9-7-21)29(17-20(2)3)35(31,32)23-10-11-24(25(16-23)34(4,27)30)28-14-12-26(13-15-28)18-33-19-26/h6-11,16,20,27H,5,12-15,17-19H2,1-4H3
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n/an/a 550n/an/an/an/an/an/a



GALDERMA RESEARCH & DEVELOPMENT

US Patent


Assay Description
This model allows measurement of the effect of inhibitors on IL-17A secretion by CD4+ cells. The cells are frozen CD4+ cells (STEMCELL, #70026), isol...


US Patent US10457637 (2019)

More data for this
Ligand-Target Pair
Interleukin-17A


(Homo sapiens (Human))
BDBM419147
PNG
(N-(4-ethylphenyl)-N- isobutyl-4-(tetrahydropyran- ...)
Show SMILES CCc1ccc(cc1)N(CC(C)C)S(=O)(=O)c1ccc(cc1)S(=O)CC1CCOCC1
Show InChI InChI=1/C24H33NO4S2/c1-4-20-5-7-22(8-6-20)25(17-19(2)3)31(27,28)24-11-9-23(10-12-24)30(26)18-21-13-15-29-16-14-21/h5-12,19,21H,4,13-18H2,1-3H3
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n/an/a 550n/an/an/an/an/an/a



GALDERMA RESEARCH & DEVELOPMENT

US Patent


Assay Description
This model allows measurement of the effect of inhibitors on IL-17A secretion by CD4+ cells. The cells are frozen CD4+ cells (STEMCELL, #70026), isol...


US Patent US10457637 (2019)

More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma (RORC)


(Homo sapiens (Human))
BDBM419196
PNG
(N-(4-ethylphenyl)-N- isobutyl-4-(tetrahydropyran- ...)
Show SMILES CCc1ccc(cc1)N(CC(C)C)S(=O)(=O)c1ccc(SCC2CCOCC2)cc1
Show InChI InChI=1S/C24H33NO3S2/c1-4-20-5-7-22(8-6-20)25(17-19(2)3)30(26,27)24-11-9-23(10-12-24)29-18-21-13-15-28-16-14-21/h5-12,19,21H,4,13-18H2,1-3H3
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n/an/a 550n/an/an/an/an/an/a



GALDERMA RESEARCH & DEVELOPMENT

US Patent


Assay Description
The RORγ transactivation model was developed from the line HG5LN, which is a HeLa line that stably expresses a luciferase reporter gene controll...


US Patent US10457637 (2019)

More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma (RORC)


(Homo sapiens (Human))
BDBM419213
PNG
(4-((1,1- dioxidotetrahydrothio- phen-3-yl)amino)-N...)
Show SMILES CCc1ccc(cc1)N(CC(C)C)S(=O)(=O)c1ccc(NC2CCS(=O)(=O)C2)c(c1)S(C)(=N)=O
Show InChI InChI=1/C23H33N3O5S3/c1-5-18-6-8-20(9-7-18)26(15-17(2)3)34(30,31)21-10-11-22(23(14-21)32(4,24)27)25-19-12-13-33(28,29)16-19/h6-11,14,17,19,24-25H,5,12-13,15-16H2,1-4H3
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n/an/a 550n/an/an/an/an/an/a



GALDERMA RESEARCH & DEVELOPMENT

US Patent


Assay Description
The RORγ transactivation model was developed from the line HG5LN, which is a HeLa line that stably expresses a luciferase reporter gene controll...


US Patent US10457637 (2019)

More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma (RORC)


(Homo sapiens (Human))
BDBM419156
PNG
(N-(4-ethylphenyl)-N- isobutyl-3-methanesulfinyl- 4...)
Show SMILES CCc1ccc(cc1)N(CC(C)C)S(=O)(=O)c1ccc(OCC2CCOCC2)c(c1)[S@](C)=O
Show InChI InChI=1/C25H35NO5S2/c1-5-20-6-8-22(9-7-20)26(17-19(2)3)33(28,29)23-10-11-24(25(16-23)32(4)27)31-18-21-12-14-30-15-13-21/h6-11,16,19,21H,5,12-15,17-18H2,1-4H3/t32-/s2
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n/an/a 550n/an/an/an/an/an/a



GALDERMA RESEARCH & DEVELOPMENT

US Patent


Assay Description
The RORγ transactivation model was developed from the line HG5LN, which is a HeLa line that stably expresses a luciferase reporter gene controll...


US Patent US10457637 (2019)

More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma (RORC)


(Homo sapiens (Human))
BDBM419201
PNG
(2,2-dimethyl-1-oxo-3- (tetrahydropyran-4- ylmethyl...)
Show SMILES CCc1ccc(cc1)N(CC(C)C)S(=O)(=O)c1ccc2N(CC3CCOCC3)C(C)(C)S(=O)c2c1
Show InChI InChI=1/C27H38N2O4S2/c1-6-21-7-9-23(10-8-21)29(18-20(2)3)35(31,32)24-11-12-25-26(17-24)34(30)27(4,5)28(25)19-22-13-15-33-16-14-22/h7-12,17,20,22H,6,13-16,18-19H2,1-5H3
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n/an/a 550n/an/an/an/an/an/a



GALDERMA RESEARCH & DEVELOPMENT

US Patent


Assay Description
The RORγ transactivation model was developed from the line HG5LN, which is a HeLa line that stably expresses a luciferase reporter gene controll...


US Patent US10457637 (2019)

More data for this
Ligand-Target Pair
Interleukin-17A


(Homo sapiens (Human))
BDBM419222
PNG
(4-(((2-oxaspiro[3.3]heptan- 6-yl)methyl)amino)-N-(...)
Show SMILES CCc1ccc(cc1)N(CC(C)C)S(=O)(=O)c1ccc(NCC2CC3(COC3)C2)c(c1)S(C)(=N)=O
Show InChI InChI=1/C26H37N3O4S2/c1-5-20-6-8-22(9-7-20)29(16-19(2)3)35(31,32)23-10-11-24(25(12-23)34(4,27)30)28-15-21-13-26(14-21)17-33-18-26/h6-12,19,21,27-28H,5,13-18H2,1-4H3
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n/an/a 550n/an/an/an/an/an/a



GALDERMA RESEARCH & DEVELOPMENT

US Patent


Assay Description
This model allows measurement of the effect of inhibitors on IL-17A secretion by CD4+ cells. The cells are frozen CD4+ cells (STEMCELL, #70026), isol...


US Patent US10457637 (2019)

More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma (RORC)


(Homo sapiens (Human))
BDBM419253
PNG
(N-(4-ethylphenyl)-N- isobutyl-3-(S- methylsulfonim...)
Show SMILES CCc1ccc(cc1)N(CC(C)C)S(=O)(=O)c1ccc(N2CCCOCC2)c(c1)S(C)(=N)=O
Show InChI InChI=1/C24H35N3O4S2/c1-5-20-7-9-21(10-8-20)27(18-19(2)3)33(29,30)22-11-12-23(24(17-22)32(4,25)28)26-13-6-15-31-16-14-26/h7-12,17,19,25H,5-6,13-16,18H2,1-4H3
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n/an/a 550n/an/an/an/an/an/a



GALDERMA RESEARCH & DEVELOPMENT

US Patent


Assay Description
The RORγ transactivation model was developed from the line HG5LN, which is a HeLa line that stably expresses a luciferase reporter gene controll...


US Patent US10457637 (2019)

More data for this
Ligand-Target Pair
Interleukin-17A


(Homo sapiens (Human))
BDBM419253
PNG
(N-(4-ethylphenyl)-N- isobutyl-3-(S- methylsulfonim...)
Show SMILES CCc1ccc(cc1)N(CC(C)C)S(=O)(=O)c1ccc(N2CCCOCC2)c(c1)S(C)(=N)=O
Show InChI InChI=1/C24H35N3O4S2/c1-5-20-7-9-21(10-8-20)27(18-19(2)3)33(29,30)22-11-12-23(24(17-22)32(4,25)28)26-13-6-15-31-16-14-26/h7-12,17,19,25H,5-6,13-16,18H2,1-4H3
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n/an/a 550n/an/an/an/an/an/a



GALDERMA RESEARCH & DEVELOPMENT

US Patent


Assay Description
This model allows measurement of the effect of inhibitors on IL-17A secretion by CD4+ cells. The cells are frozen CD4+ cells (STEMCELL, #70026), isol...


US Patent US10457637 (2019)

More data for this
Ligand-Target Pair
Interleukin-17A


(Homo sapiens (Human))
BDBM419158
PNG
(US10457637, Compound 22 | ethanesulfinyl-N-(4- eth...)
Show SMILES CCc1ccc(cc1)N(CC(C)C)S(=O)(=O)c1ccc(OCC2CCOCC2)c(c1)S(=O)CC
Show InChI InChI=1/C26H37NO5S2/c1-5-21-7-9-23(10-8-21)27(18-20(3)4)34(29,30)24-11-12-25(26(17-24)33(28)6-2)32-19-22-13-15-31-16-14-22/h7-12,17,20,22H,5-6,13-16,18-19H2,1-4H3
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n/an/a 550n/an/an/an/an/an/a



GALDERMA RESEARCH & DEVELOPMENT

US Patent


Assay Description
This model allows measurement of the effect of inhibitors on IL-17A secretion by CD4+ cells. The cells are frozen CD4+ cells (STEMCELL, #70026), isol...


US Patent US10457637 (2019)

More data for this
Ligand-Target Pair
Interleukin-17A


(Homo sapiens (Human))
BDBM50461079
PNG
(CHEMBL4227543 | US10457637, Compound 65)
Show SMILES CCc1ccc(cc1)N(CC(C)C)S(=O)(=O)c1ccc(CCN2CCOCC2)c(c1)S(C)(=N)=O
Show InChI InChI=1S/C25H37N3O4S2/c1-5-21-6-9-23(10-7-21)28(19-20(2)3)34(30,31)24-11-8-22(25(18-24)33(4,26)29)12-13-27-14-16-32-17-15-27/h6-11,18,20,26H,5,12-17,19H2,1-4H3
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n/an/a 550n/an/an/an/an/an/a



GALDERMA RESEARCH & DEVELOPMENT

US Patent


Assay Description
This model allows measurement of the effect of inhibitors on IL-17A secretion by CD4+ cells. The cells are frozen CD4+ cells (STEMCELL, #70026), isol...


US Patent US10457637 (2019)

More data for this
Ligand-Target Pair
Interleukin-17A


(Homo sapiens (Human))
BDBM419196
PNG
(N-(4-ethylphenyl)-N- isobutyl-4-(tetrahydropyran- ...)
Show SMILES CCc1ccc(cc1)N(CC(C)C)S(=O)(=O)c1ccc(SCC2CCOCC2)cc1
Show InChI InChI=1S/C24H33NO3S2/c1-4-20-5-7-22(8-6-20)25(17-19(2)3)30(26,27)24-11-9-23(10-12-24)29-18-21-13-15-28-16-14-21/h5-12,19,21H,4,13-18H2,1-3H3
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n/an/a 550n/an/an/an/an/an/a



GALDERMA RESEARCH & DEVELOPMENT

US Patent


Assay Description
This model allows measurement of the effect of inhibitors on IL-17A secretion by CD4+ cells. The cells are frozen CD4+ cells (STEMCELL, #70026), isol...


US Patent US10457637 (2019)

More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma (RORC)


(Homo sapiens (Human))
BDBM419199
PNG
(3-oxo-4-(tetrahydropyran-4- ylmethyl)-3,4-dihydro-...)
Show SMILES CCc1ccc(cc1)N(CC(C)C)S(=O)(=O)c1ccc2n(CC3CCOCC3)c(=O)sc2c1
Show InChI InChI=1S/C25H32N2O4S2/c1-4-19-5-7-21(8-6-19)27(16-18(2)3)33(29,30)22-9-10-23-24(15-22)32-25(28)26(23)17-20-11-13-31-14-12-20/h5-10,15,18,20H,4,11-14,16-17H2,1-3H3
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n/an/a 550n/an/an/an/an/an/a



GALDERMA RESEARCH & DEVELOPMENT

US Patent


Assay Description
The RORγ transactivation model was developed from the line HG5LN, which is a HeLa line that stably expresses a luciferase reporter gene controll...


US Patent US10457637 (2019)

More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma (RORC)


(Homo sapiens (Human))
BDBM50461087
PNG
(CHEMBL4226731 | US10457637, Compound 92)
Show SMILES CCc1ccc(cc1)N(CC(C)C)S(=O)(=O)c1ccc(NCC2(O)CCOCC2)c(c1)S(C)(=N)=O
Show InChI InChI=1S/C25H37N3O5S2/c1-5-20-6-8-21(9-7-20)28(17-19(2)3)35(31,32)22-10-11-23(24(16-22)34(4,26)30)27-18-25(29)12-14-33-15-13-25/h6-11,16,19,26-27,29H,5,12-15,17-18H2,1-4H3
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n/an/a 550n/an/an/an/an/an/a



GALDERMA RESEARCH & DEVELOPMENT

US Patent


Assay Description
The RORγ transactivation model was developed from the line HG5LN, which is a HeLa line that stably expresses a luciferase reporter gene controll...


US Patent US10457637 (2019)

More data for this
Ligand-Target Pair
Interleukin-17A


(Homo sapiens (Human))
BDBM50461087
PNG
(CHEMBL4226731 | US10457637, Compound 92)
Show SMILES CCc1ccc(cc1)N(CC(C)C)S(=O)(=O)c1ccc(NCC2(O)CCOCC2)c(c1)S(C)(=N)=O
Show InChI InChI=1S/C25H37N3O5S2/c1-5-20-6-8-21(9-7-20)28(17-19(2)3)35(31,32)22-10-11-23(24(16-22)34(4,26)30)27-18-25(29)12-14-33-15-13-25/h6-11,16,19,26-27,29H,5,12-15,17-18H2,1-4H3
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n/an/a 550n/an/an/an/an/an/a



GALDERMA RESEARCH & DEVELOPMENT

US Patent


Assay Description
This model allows measurement of the effect of inhibitors on IL-17A secretion by CD4+ cells. The cells are frozen CD4+ cells (STEMCELL, #70026), isol...


US Patent US10457637 (2019)

More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma (RORC)


(Homo sapiens (Human))
BDBM419236
PNG
(N-(4-ethylphenyl)-N- isobutyl-3-(S- methylsulfonim...)
Show SMILES CCc1ccc(cc1)N(CC(C)C)S(=O)(=O)c1ccc(N2CCC3(COC3)CC2)c(c1)S(C)(=N)=O
Show InChI InChI=1/C26H37N3O4S2/c1-5-21-6-8-22(9-7-21)29(17-20(2)3)35(31,32)23-10-11-24(25(16-23)34(4,27)30)28-14-12-26(13-15-28)18-33-19-26/h6-11,16,20,27H,5,12-15,17-19H2,1-4H3
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n/an/a 550n/an/an/an/an/an/a



GALDERMA RESEARCH & DEVELOPMENT

US Patent


Assay Description
The RORγ transactivation model was developed from the line HG5LN, which is a HeLa line that stably expresses a luciferase reporter gene controll...


US Patent US10457637 (2019)

More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma (RORC)


(Homo sapiens (Human))
BDBM419238
PNG
(4-((1R,4R)-2-oxa-5- azabicyclo[2.2.1]heptan-5- yl)...)
Show SMILES CCc1ccc(cc1)N(CC(C)C)S(=O)(=O)c1ccc(N2CC3CC2CO3)c(c1)S(C)(=N)=O
Show InChI InChI=1/C24H33N3O4S2/c1-5-18-6-8-19(9-7-18)27(14-17(2)3)33(29,30)22-10-11-23(24(13-22)32(4,25)28)26-15-21-12-20(26)16-31-21/h6-11,13,17,20-21,25H,5,12,14-16H2,1-4H3
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n/an/a 550n/an/an/an/an/an/a



GALDERMA RESEARCH & DEVELOPMENT

US Patent


Assay Description
The RORγ transactivation model was developed from the line HG5LN, which is a HeLa line that stably expresses a luciferase reporter gene controll...


US Patent US10457637 (2019)

More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma (RORC)


(Homo sapiens (Human))
BDBM419257
PNG
(N-isopropyl-N-(4-methoxy- 2-methylphenyl)-3-(S- me...)
Show SMILES COc1ccc(N(C(C)C)S(=O)(=O)c2ccc(OCC3CCOCC3)c(c2)S(C)(=N)=O)c(C)c1
Show InChI InChI=1/C24H34N2O6S2/c1-17(2)26(22-8-6-20(30-4)14-18(22)3)34(28,29)21-7-9-23(24(15-21)33(5,25)27)32-16-19-10-12-31-13-11-19/h6-9,14-15,17,19,25H,10-13,16H2,1-5H3
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n/an/a 550n/an/an/an/an/an/a



GALDERMA RESEARCH & DEVELOPMENT

US Patent


Assay Description
The RORγ transactivation model was developed from the line HG5LN, which is a HeLa line that stably expresses a luciferase reporter gene controll...


US Patent US10457637 (2019)

More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma (RORC)


(Homo sapiens (Human))
BDBM419144
PNG
(N-(4-ethylphenyl)-3- hydroxymethyl-N-isobutyl- 4-(...)
Show SMILES CCc1ccc(cc1)N(CC(C)C)S(=O)(=O)c1ccc(c(CO)c1)S(=O)CC1CCOCC1
Show InChI InChI=1/C25H35NO5S2/c1-4-20-5-7-23(8-6-20)26(16-19(2)3)33(29,30)24-9-10-25(22(15-24)17-27)32(28)18-21-11-13-31-14-12-21/h5-10,15,19,21,27H,4,11-14,16-18H2,1-3H3
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n/an/a 550n/an/an/an/an/an/a



GALDERMA RESEARCH & DEVELOPMENT

US Patent


Assay Description
The RORγ transactivation model was developed from the line HG5LN, which is a HeLa line that stably expresses a luciferase reporter gene controll...


US Patent US10457637 (2019)

More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma (RORC)


(Homo sapiens (Human))
BDBM419148
PNG
(N-(4-ethylphenyl)-N- isobutyl-4-(tetrahydropyran- ...)
Show SMILES CCc1ccc(cc1)N(CC(C)C)S(=O)(=O)c1ccc(cc1)S(=O)CC1CCOCC1
Show InChI InChI=1/C24H33NO4S2/c1-4-20-5-7-22(8-6-20)25(17-19(2)3)31(27,28)24-11-9-23(10-12-24)30(26)18-21-13-15-29-16-14-21/h5-12,19,21H,4,13-18H2,1-3H3
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n/an/a 550n/an/an/an/an/an/a



GALDERMA RESEARCH & DEVELOPMENT

US Patent


Assay Description
The RORγ transactivation model was developed from the line HG5LN, which is a HeLa line that stably expresses a luciferase reporter gene controll...


US Patent US10457637 (2019)

More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma (RORC)


(Homo sapiens (Human))
BDBM419155
PNG
(N-(4-ethylphenyl)-N- isobutyl-3-methanesulfinyl- 4...)
Show SMILES CCc1ccc(cc1)N(CC(C)C)S(=O)(=O)c1ccc(OCC2CCOCC2)c(c1)[S@@](C)=O
Show InChI InChI=1/C25H35NO5S2/c1-5-20-6-8-22(9-7-20)26(17-19(2)3)33(28,29)23-10-11-24(25(16-23)32(4)27)31-18-21-12-14-30-15-13-21/h6-11,16,19,21H,5,12-15,17-18H2,1-4H3/t32-/s2
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n/an/a 550n/an/an/an/an/an/a



GALDERMA RESEARCH & DEVELOPMENT

US Patent


Assay Description
The RORγ transactivation model was developed from the line HG5LN, which is a HeLa line that stably expresses a luciferase reporter gene controll...


US Patent US10457637 (2019)

More data for this
Ligand-Target Pair
Interleukin-17A


(Homo sapiens (Human))
BDBM419187
PNG
(N-(4-ethylphenyl)-N- isobutyl-3-(S- methylsulfonim...)
Show SMILES CCc1ccc(cc1)N(CC(C)C)S(=O)(=O)c1ccc(NCC2CNC(=O)C2)c(c1)S(C)(=N)=O
Show InChI InChI=1/C24H34N4O4S2/c1-5-18-6-8-20(9-7-18)28(16-17(2)3)34(31,32)21-10-11-22(23(13-21)33(4,25)30)26-14-19-12-24(29)27-15-19/h6-11,13,17,19,25-26H,5,12,14-16H2,1-4H3,(H,27,29)
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n/an/a 550n/an/an/an/an/an/a



GALDERMA RESEARCH & DEVELOPMENT

US Patent


Assay Description
This model allows measurement of the effect of inhibitors on IL-17A secretion by CD4+ cells. The cells are frozen CD4+ cells (STEMCELL, #70026), isol...


US Patent US10457637 (2019)

More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma (RORC)


(Homo sapiens (Human))
BDBM419234
PNG
(N-(4-ethylphenyl)-N- isobutyl-3-(S- methylsulfonim...)
Show SMILES CCc1ccc(cc1)N(CC(C)C)S(=O)(=O)c1ccc(N2CCC3(COC3)C2)c(c1)S(C)(=N)=O
Show InChI InChI=1/C25H35N3O4S2/c1-5-20-6-8-21(9-7-20)28(15-19(2)3)34(30,31)22-10-11-23(24(14-22)33(4,26)29)27-13-12-25(16-27)17-32-18-25/h6-11,14,19,26H,5,12-13,15-18H2,1-4H3
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n/an/a 550n/an/an/an/an/an/a



GALDERMA RESEARCH & DEVELOPMENT

US Patent


Assay Description
The RORγ transactivation model was developed from the line HG5LN, which is a HeLa line that stably expresses a luciferase reporter gene controll...


US Patent US10457637 (2019)

More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma (RORC)


(Homo sapiens (Human))
BDBM419235
PNG
(4-(2,2-dioxido-2-thia-6- azaspiro[3.3]heptan-6-yl)...)
Show SMILES CCc1ccc(cc1)N(CC(C)C)S(=O)(=O)c1ccc(N2CC3(C2)CS(=O)(=O)C3)c(c1)S(C)(=N)=O
Show InChI InChI=1/C24H33N3O5S3/c1-5-19-6-8-20(9-7-19)27(13-18(2)3)35(31,32)21-10-11-22(23(12-21)33(4,25)28)26-14-24(15-26)16-34(29,30)17-24/h6-12,18,25H,5,13-17H2,1-4H3
PDB

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n/an/a 550n/an/an/an/an/an/a



GALDERMA RESEARCH & DEVELOPMENT

US Patent


Assay Description
The RORγ transactivation model was developed from the line HG5LN, which is a HeLa line that stably expresses a luciferase reporter gene controll...


US Patent US10457637 (2019)

More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma (RORC)


(Homo sapiens (Human))
BDBM419244
PNG
(N-(4-ethylphenyl)-N- isobutyl-4-(((4- methoxytetra...)
Show SMILES CCc1ccc(cc1)N(CC(C)C)S(=O)(=O)c1ccc(NCC2(CCOCC2)OC)c(c1)S(C)(=N)=O
Show InChI InChI=1/C26H39N3O5S2/c1-6-21-7-9-22(10-8-21)29(18-20(2)3)36(31,32)23-11-12-24(25(17-23)35(5,27)30)28-19-26(33-4)13-15-34-16-14-26/h7-12,17,20,27-28H,6,13-16,18-19H2,1-5H3
PDB

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n/an/a 550n/an/an/an/an/an/a



GALDERMA RESEARCH & DEVELOPMENT

US Patent


Assay Description
The RORγ transactivation model was developed from the line HG5LN, which is a HeLa line that stably expresses a luciferase reporter gene controll...


US Patent US10457637 (2019)

More data for this
Ligand-Target Pair
Interleukin-17A


(Homo sapiens (Human))
BDBM419246
PNG
(N-(4-ethylphenyl)-N- isobutyl-4-(((2- methoxypyrid...)
Show SMILES CCc1ccc(cc1)N(CC(C)C)S(=O)(=O)c1ccc(NCc2ccnc(OC)c2)c(c1)S(C)(=N)=O
Show InChI InChI=1/C26H34N4O4S2/c1-6-20-7-9-22(10-8-20)30(18-19(2)3)36(32,33)23-11-12-24(25(16-23)35(5,27)31)29-17-21-13-14-28-26(15-21)34-4/h7-16,19,27,29H,6,17-18H2,1-5H3
PDB

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n/an/a 550n/an/an/an/an/an/a



GALDERMA RESEARCH & DEVELOPMENT

US Patent


Assay Description
This model allows measurement of the effect of inhibitors on IL-17A secretion by CD4+ cells. The cells are frozen CD4+ cells (STEMCELL, #70026), isol...


US Patent US10457637 (2019)

More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma (RORC)


(Homo sapiens (Human))
BDBM419240
PNG
(-(4-ethylphenyl)-N- isobutyl-3-(S- methylsulfonimi...)
Show SMILES CCc1ccc(cc1)N(CC(C)C)S(=O)(=O)c1ccc(N2CC3(CNC3)C2)c(c1)S(C)(=N)=O
Show InChI InChI=1/C24H34N4O3S2/c1-5-19-6-8-20(9-7-19)28(13-18(2)3)33(30,31)21-10-11-22(23(12-21)32(4,25)29)27-16-24(17-27)14-26-15-24/h6-12,18,25-26H,5,13-17H2,1-4H3
PDB

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n/an/a>1.00E+3n/an/an/an/an/an/a



GALDERMA RESEARCH & DEVELOPMENT

US Patent


Assay Description
The RORγ transactivation model was developed from the line HG5LN, which is a HeLa line that stably expresses a luciferase reporter gene controll...


US Patent US10457637 (2019)

More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma (RORC)


(Homo sapiens (Human))
BDBM419251
PNG
(N-(4-ethylphenyl)-N- isobutyl-3-(S- methylsulfonim...)
Show SMILES CCc1ccc(cc1)N(CC(C)C)S(=O)(=O)c1ccc(NCC2(COC2)N2CCCC2)c(c1)S(C)(=N)=O
Show InChI InChI=1/C27H40N4O4S2/c1-5-22-8-10-23(11-9-22)31(17-21(2)3)37(33,34)24-12-13-25(26(16-24)36(4,28)32)29-18-27(19-35-20-27)30-14-6-7-15-30/h8-13,16,21,28-29H,5-7,14-15,17-20H2,1-4H3
PDB

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n/an/a>1.00E+3n/an/an/an/an/an/a



GALDERMA RESEARCH & DEVELOPMENT

US Patent


Assay Description
The RORγ transactivation model was developed from the line HG5LN, which is a HeLa line that stably expresses a luciferase reporter gene controll...


US Patent US10457637 (2019)

More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma (RORC)


(Homo sapiens (Human))
BDBM419248
PNG
(N-(4-ethylphenyl)-4-((S)-3- hydroxypyrrolidin-1-yl...)
Show SMILES CCc1ccc(cc1)N(CC(C)C)S(=O)(=O)c1ccc(N2CC[C@H](O)C2)c(c1)S(C)(=N)=O
Show InChI InChI=1/C23H33N3O4S2/c1-5-18-6-8-19(9-7-18)26(15-17(2)3)32(29,30)21-10-11-22(23(14-21)31(4,24)28)25-13-12-20(27)16-25/h6-11,14,17,20,24,27H,5,12-13,15-16H2,1-4H3/t20-,31?/s2
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n/an/a>1.00E+3n/an/an/an/an/an/a



GALDERMA RESEARCH & DEVELOPMENT

US Patent


Assay Description
The RORγ transactivation model was developed from the line HG5LN, which is a HeLa line that stably expresses a luciferase reporter gene controll...


US Patent US10457637 (2019)

More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma (RORC)


(Homo sapiens (Human))
BDBM419247
PNG
(N-(4-ethylphenyl)-4-(4- hydroxypiperidin-1-yl)-N- ...)
Show SMILES CCc1ccc(cc1)N(CC(C)C)S(=O)(=O)c1ccc(N2CCC(O)CC2)c(c1)S(C)(=N)=O
Show InChI InChI=1/C24H35N3O4S2/c1-5-19-6-8-20(9-7-19)27(17-18(2)3)33(30,31)22-10-11-23(24(16-22)32(4,25)29)26-14-12-21(28)13-15-26/h6-11,16,18,21,25,28H,5,12-15,17H2,1-4H3
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n/an/a>1.00E+3n/an/an/an/an/an/a



GALDERMA RESEARCH & DEVELOPMENT

US Patent


Assay Description
The RORγ transactivation model was developed from the line HG5LN, which is a HeLa line that stably expresses a luciferase reporter gene controll...


US Patent US10457637 (2019)

More data for this
Ligand-Target Pair
Interleukin-17A


(Homo sapiens (Human))
BDBM419249
PNG
(N-(4-ethylphenyl)-4-((R)- 3-hydroxypyrrolidin-1-yl...)
Show SMILES CCc1ccc(cc1)N(CC(C)C)S(=O)(=O)c1ccc(N2CC[C@@H](O)C2)c(c1)S(C)(=N)=O
Show InChI InChI=1/C23H33N3O4S2/c1-5-18-6-8-19(9-7-18)26(15-17(2)3)32(29,30)21-10-11-22(23(14-21)31(4,24)28)25-13-12-20(27)16-25/h6-11,14,17,20,24,27H,5,12-13,15-16H2,1-4H3/t20-,31?/s2
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n/an/a>1.00E+3n/an/an/an/an/an/a



GALDERMA RESEARCH & DEVELOPMENT

US Patent


Assay Description
This model allows measurement of the effect of inhibitors on IL-17A secretion by CD4+ cells. The cells are frozen CD4+ cells (STEMCELL, #70026), isol...


US Patent US10457637 (2019)

More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma (RORC)


(Homo sapiens (Human))
BDBM419136
PNG
(1-oxo-4-(tetrahydropyran-4- ylmethyl)-1,2,3,4- tet...)
Show SMILES CCc1ccc(cc1)N(CC(C)C)S(=O)(=O)c1ccc2c(c1)N(CC1CCOCC1)CCS2=O
Show InChI InChI=1/C26H36N2O4S2/c1-4-21-5-7-23(8-6-21)28(18-20(2)3)34(30,31)24-9-10-26-25(17-24)27(13-16-33(26)29)19-22-11-14-32-15-12-22/h5-10,17,20,22H,4,11-16,18-19H2,1-3H3
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n/an/a>1.00E+3n/an/an/an/an/an/a



GALDERMA RESEARCH & DEVELOPMENT

US Patent


Assay Description
The RORγ transactivation model was developed from the line HG5LN, which is a HeLa line that stably expresses a luciferase reporter gene controll...


US Patent US10457637 (2019)

More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma (RORC)


(Homo sapiens (Human))
BDBM419170
PNG
(N-(4-ethylphenyl)-N- isobutyl-4-(2-(isoxazol-5- yl...)
Show SMILES CCc1ccc(cc1)N(CC(C)C)S(=O)(=O)c1ccc(OCCc2ccno2)c(c1)S(C)(=N)=O
Show InChI InChI=1/C24H31N3O5S2/c1-5-19-6-8-20(9-7-19)27(17-18(2)3)34(29,30)22-10-11-23(24(16-22)33(4,25)28)31-15-13-21-12-14-26-32-21/h6-12,14,16,18,25H,5,13,15,17H2,1-4H3
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n/an/a>1.00E+3n/an/an/an/an/an/a



GALDERMA RESEARCH & DEVELOPMENT

US Patent


Assay Description
The RORγ transactivation model was developed from the line HG5LN, which is a HeLa line that stably expresses a luciferase reporter gene controll...


US Patent US10457637 (2019)

More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma (RORC)


(Homo sapiens (Human))
BDBM419174
PNG
(4-((2,6-dimethylpyridin-4- yl)methoxy)-N-(4- ethyl...)
Show SMILES CCc1ccc(cc1)N(CC(C)C)S(=O)(=O)c1ccc(OCc2cc(C)nc(C)c2)c(c1)S(C)(=N)=O
Show InChI InChI=1/C27H35N3O4S2/c1-7-22-8-10-24(11-9-22)30(17-19(2)3)36(32,33)25-12-13-26(27(16-25)35(6,28)31)34-18-23-14-20(4)29-21(5)15-23/h8-16,19,28H,7,17-18H2,1-6H3
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n/an/a>1.00E+3n/an/an/an/an/an/a



GALDERMA RESEARCH & DEVELOPMENT

US Patent


Assay Description
The RORγ transactivation model was developed from the line HG5LN, which is a HeLa line that stably expresses a luciferase reporter gene controll...


US Patent US10457637 (2019)

More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma (RORC)


(Homo sapiens (Human))
BDBM50461072
PNG
(CHEMBL4227463 | US10457637, Compound 47)
Show SMILES CCc1ccc(cc1)N(CC(C)C)S(=O)(=O)c1ccc(OC2CCN(CC2)C(C)=O)c(c1)S(C)(=N)=O
Show InChI InChI=1S/C26H37N3O5S2/c1-6-21-7-9-22(10-8-21)29(18-19(2)3)36(32,33)24-11-12-25(26(17-24)35(5,27)31)34-23-13-15-28(16-14-23)20(4)30/h7-12,17,19,23,27H,6,13-16,18H2,1-5H3
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n/an/a>1.00E+3n/an/an/an/an/an/a



GALDERMA RESEARCH & DEVELOPMENT

US Patent


Assay Description
The RORγ transactivation model was developed from the line HG5LN, which is a HeLa line that stably expresses a luciferase reporter gene controll...


US Patent US10457637 (2019)

More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma (RORC)


(Homo sapiens (Human))
BDBM419180
PNG
(4-((1-acetylpiperidin-4- yl)methoxy)-N-(4- ethylph...)
Show SMILES CCc1ccc(cc1)N(CC(C)C)S(=O)(=O)c1ccc(OCC2CCN(CC2)C(C)=O)c(c1)S(C)(=N)=O
Show InChI InChI=1/C27H39N3O5S2/c1-6-22-7-9-24(10-8-22)30(18-20(2)3)37(33,34)25-11-12-26(27(17-25)36(5,28)32)35-19-23-13-15-29(16-14-23)21(4)31/h7-12,17,20,23,28H,6,13-16,18-19H2,1-5H3
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n/an/a>1.00E+3n/an/an/an/an/an/a



GALDERMA RESEARCH & DEVELOPMENT

US Patent


Assay Description
The RORγ transactivation model was developed from the line HG5LN, which is a HeLa line that stably expresses a luciferase reporter gene controll...


US Patent US10457637 (2019)

More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma (RORC)


(Homo sapiens (Human))
BDBM419227
PNG
(N-(4-ethylphenyl)-N- isobutyl-4-((R)-3- methylmorp...)
Show SMILES CCc1ccc(cc1)N(CC(C)C)S(=O)(=O)c1ccc(N2CCOC[C@H]2C)c(c1)S(C)(=N)=O
Show InChI InChI=1/C24H35N3O4S2/c1-6-20-7-9-21(10-8-20)27(16-18(2)3)33(29,30)22-11-12-23(24(15-22)32(5,25)28)26-13-14-31-17-19(26)4/h7-12,15,18-19,25H,6,13-14,16-17H2,1-5H3/t19-,32?/s2
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n/an/a>1.00E+3n/an/an/an/an/an/a



GALDERMA RESEARCH & DEVELOPMENT

US Patent


Assay Description
The RORγ transactivation model was developed from the line HG5LN, which is a HeLa line that stably expresses a luciferase reporter gene controll...


US Patent US10457637 (2019)

More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma (RORC)


(Homo sapiens (Human))
BDBM419231
PNG
(N-(4-ethylphenyl)-N- isobutyl-3-(S- methylsulfonim...)
Show SMILES CCc1ccc(cc1)N(CC(C)C)S(=O)(=O)c1ccc(N2CCCC3(COC3)C2)c(c1)S(C)(=N)=O
Show InChI InChI=1/C26H37N3O4S2/c1-5-21-7-9-22(10-8-21)29(16-20(2)3)35(31,32)23-11-12-24(25(15-23)34(4,27)30)28-14-6-13-26(17-28)18-33-19-26/h7-12,15,20,27H,5-6,13-14,16-19H2,1-4H3
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n/an/a>1.00E+3n/an/an/an/an/an/a



GALDERMA RESEARCH & DEVELOPMENT

US Patent


Assay Description
The RORγ transactivation model was developed from the line HG5LN, which is a HeLa line that stably expresses a luciferase reporter gene controll...


US Patent US10457637 (2019)

More data for this
Ligand-Target Pair
Interleukin-17A


(Homo sapiens (Human))
BDBM419247
PNG
(N-(4-ethylphenyl)-4-(4- hydroxypiperidin-1-yl)-N- ...)
Show SMILES CCc1ccc(cc1)N(CC(C)C)S(=O)(=O)c1ccc(N2CCC(O)CC2)c(c1)S(C)(=N)=O
Show InChI InChI=1/C24H35N3O4S2/c1-5-19-6-8-20(9-7-19)27(17-18(2)3)33(30,31)22-10-11-23(24(16-22)32(4,25)29)26-14-12-21(28)13-15-26/h6-11,16,18,21,25,28H,5,12-15,17H2,1-4H3
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n/an/a>1.00E+3n/an/an/an/an/an/a



GALDERMA RESEARCH & DEVELOPMENT

US Patent


Assay Description
This model allows measurement of the effect of inhibitors on IL-17A secretion by CD4+ cells. The cells are frozen CD4+ cells (STEMCELL, #70026), isol...


US Patent US10457637 (2019)

More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma (RORC)


(Homo sapiens (Human))
BDBM419250
PNG
(N-(4-ethylphenyl)-4-(3- hydroxyazetidin-1-yl)-N- i...)
Show SMILES CCc1ccc(cc1)N(CC(C)C)S(=O)(=O)c1ccc(N2CC(O)C2)c(c1)S(C)(=N)=O
Show InChI InChI=1/C22H31N3O4S2/c1-5-17-6-8-18(9-7-17)25(13-16(2)3)31(28,29)20-10-11-21(24-14-19(26)15-24)22(12-20)30(4,23)27/h6-12,16,19,23,26H,5,13-15H2,1-4H3
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n/an/a>1.00E+3n/an/an/an/an/an/a



GALDERMA RESEARCH & DEVELOPMENT

US Patent


Assay Description
The RORγ transactivation model was developed from the line HG5LN, which is a HeLa line that stably expresses a luciferase reporter gene controll...


US Patent US10457637 (2019)

More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma (RORC)


(Homo sapiens (Human))
BDBM419151
PNG
(US10457637, Compound 16 | methyl 5-[(4- ethylpheny...)
Show SMILES CCc1ccc(cc1)N(CC(C)C)S(=O)(=O)c1ccc(c(c1)C(=O)OC)S(=O)CC1CCOCC1
Show InChI InChI=1/C26H35NO6S2/c1-5-20-6-8-22(9-7-20)27(17-19(2)3)35(30,31)23-10-11-25(24(16-23)26(28)32-4)34(29)18-21-12-14-33-15-13-21/h6-11,16,19,21H,5,12-15,17-18H2,1-4H3
PDB

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n/an/a>1.00E+3n/an/an/an/an/an/a



GALDERMA RESEARCH & DEVELOPMENT

US Patent


Assay Description
The RORγ transactivation model was developed from the line HG5LN, which is a HeLa line that stably expresses a luciferase reporter gene controll...


US Patent US10457637 (2019)

More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma (RORC)


(Homo sapiens (Human))
BDBM419168
PNG
(US10457637, Compound 36 | tert-butyl 4-((4-(N-(4- ...)
Show SMILES CCc1ccc(cc1)N(CC(C)C)S(=O)(=O)c1ccc(OCC2CCN(CC2)C(=O)OC(C)(C)C)c(c1)S(C)(=N)=O
Show InChI InChI=1/C30H45N3O6S2/c1-8-23-9-11-25(12-10-23)33(20-22(2)3)41(36,37)26-13-14-27(28(19-26)40(7,31)35)38-21-24-15-17-32(18-16-24)29(34)39-30(4,5)6/h9-14,19,22,24,31H,8,15-18,20-21H2,1-7H3
PDB

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n/an/a>1.00E+3n/an/an/an/an/an/a



GALDERMA RESEARCH & DEVELOPMENT

US Patent


Assay Description
The RORγ transactivation model was developed from the line HG5LN, which is a HeLa line that stably expresses a luciferase reporter gene controll...


US Patent US10457637 (2019)

More data for this
Ligand-Target Pair
Interleukin-17A


(Homo sapiens (Human))
BDBM50461082
PNG
(CHEMBL4226691 | US10457637, Compound 63)
Show SMILES CCc1ccc(cc1)N(CC(C)C)S(=O)(=O)c1ccc(N2CCN(CC2)C(C)=O)c(c1)S(C)(=N)=O
Show InChI InChI=1S/C25H36N4O4S2/c1-6-21-7-9-22(10-8-21)29(18-19(2)3)35(32,33)23-11-12-24(25(17-23)34(5,26)31)28-15-13-27(14-16-28)20(4)30/h7-12,17,19,26H,6,13-16,18H2,1-5H3
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n/an/a>1.00E+3n/an/an/an/an/an/a



GALDERMA RESEARCH & DEVELOPMENT

US Patent


Assay Description
This model allows measurement of the effect of inhibitors on IL-17A secretion by CD4+ cells. The cells are frozen CD4+ cells (STEMCELL, #70026), isol...


US Patent US10457637 (2019)

More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma (RORC)


(Homo sapiens (Human))
BDBM419204
PNG
(N-(4-ethylphenyl)-N- isobutyl-4-((2- methoxypyridi...)
Show SMILES CCc1ccc(cc1)N(CC(C)C)S(=O)(=O)c1ccc(OCc2ccnc(OC)c2)c(c1)S(C)(=N)=O
Show InChI InChI=1/C26H33N3O5S2/c1-6-20-7-9-22(10-8-20)29(17-19(2)3)36(31,32)23-11-12-24(25(16-23)35(5,27)30)34-18-21-13-14-28-26(15-21)33-4/h7-16,19,27H,6,17-18H2,1-5H3
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n/an/a>1.00E+3n/an/an/an/an/an/a



GALDERMA RESEARCH & DEVELOPMENT

US Patent


Assay Description
The RORγ transactivation model was developed from the line HG5LN, which is a HeLa line that stably expresses a luciferase reporter gene controll...


US Patent US10457637 (2019)

More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma (RORC)


(Homo sapiens (Human))
BDBM419206
PNG
(N-(4-ethylphenyl)-N- isobutyl-3-(S- methylsulfonim...)
Show SMILES CCc1ccc(cc1)N(CC(C)C)S(=O)(=O)c1ccc(OC[C@H]2CNC(=O)O2)c(c1)S(C)(=N)=O
Show InChI InChI=1/C23H31N3O6S2/c1-5-17-6-8-18(9-7-17)26(14-16(2)3)34(29,30)20-10-11-21(22(12-20)33(4,24)28)31-15-19-13-25-23(27)32-19/h6-12,16,19,24H,5,13-15H2,1-4H3,(H,25,27)/t19-,33?/s2
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n/an/a>1.00E+3n/an/an/an/an/an/a



GALDERMA RESEARCH & DEVELOPMENT

US Patent


Assay Description
The RORγ transactivation model was developed from the line HG5LN, which is a HeLa line that stably expresses a luciferase reporter gene controll...


US Patent US10457637 (2019)

More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma (RORC)


(Homo sapiens (Human))
BDBM419241
PNG
(4-(6-acetyl-2,6- diazaspiro[3.3]heptan-2- yl)-N-(4...)
Show SMILES CCc1ccc(cc1)N(CC(C)C)S(=O)(=O)c1ccc(N2CC3(CN(C3)C(C)=O)C2)c(c1)S(C)(=N)=O
Show InChI InChI=1/C26H36N4O4S2/c1-6-21-7-9-22(10-8-21)30(14-19(2)3)36(33,34)23-11-12-24(25(13-23)35(5,27)32)29-17-26(18-29)15-28(16-26)20(4)31/h7-13,19,27H,6,14-18H2,1-5H3
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n/an/a>1.00E+3n/an/an/an/an/an/a



GALDERMA RESEARCH & DEVELOPMENT

US Patent


Assay Description
The RORγ transactivation model was developed from the line HG5LN, which is a HeLa line that stably expresses a luciferase reporter gene controll...


US Patent US10457637 (2019)

More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma (RORC)


(Homo sapiens (Human))
BDBM419202
PNG
(1-oxo-3-(tetrahydropyran-4- ylmethyl)-2,3-dihydro-...)
Show SMILES CCc1ccc(cc1)N(CC(C)C)S(=O)(=O)c1ccc2N(CC3CCOCC3)CS(=O)c2c1
Show InChI InChI=1/C25H34N2O4S2/c1-4-20-5-7-22(8-6-20)27(16-19(2)3)33(29,30)23-9-10-24-25(15-23)32(28)18-26(24)17-21-11-13-31-14-12-21/h5-10,15,19,21H,4,11-14,16-18H2,1-3H3
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n/an/a>1.00E+3n/an/an/an/an/an/a



GALDERMA RESEARCH & DEVELOPMENT

US Patent


Assay Description
The RORγ transactivation model was developed from the line HG5LN, which is a HeLa line that stably expresses a luciferase reporter gene controll...


US Patent US10457637 (2019)

More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma (RORC)


(Homo sapiens (Human))
BDBM419217
PNG
(N-(4-ethylphenyl)-N- isobutyl-4-(((2- methylpyridi...)
Show SMILES CCc1ccc(cc1)N(CC(C)C)S(=O)(=O)c1ccc(NCc2ccnc(C)c2)c(c1)S(C)(=N)=O
Show InChI InChI=1/C26H34N4O3S2/c1-6-21-7-9-23(10-8-21)30(18-19(2)3)35(32,33)24-11-12-25(26(16-24)34(5,27)31)29-17-22-13-14-28-20(4)15-22/h7-16,19,27,29H,6,17-18H2,1-5H3
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n/an/a>1.00E+3n/an/an/an/an/an/a



GALDERMA RESEARCH & DEVELOPMENT

US Patent


Assay Description
The RORγ transactivation model was developed from the line HG5LN, which is a HeLa line that stably expresses a luciferase reporter gene controll...


US Patent US10457637 (2019)

More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma (RORC)


(Homo sapiens (Human))
BDBM419221
PNG
(US10457637, Compound 94 | methyl 3-(((4-(N-(4- eth...)
Show SMILES CCc1ccc(cc1)N(CC(C)C)S(=O)(=O)c1ccc(NCC2CCN(C2)C(=O)OC)c(c1)S(C)(=N)=O
Show InChI InChI=1/C26H38N4O5S2/c1-6-20-7-9-22(10-8-20)30(17-19(2)3)37(33,34)23-11-12-24(25(15-23)36(5,27)32)28-16-21-13-14-29(18-21)26(31)35-4/h7-12,15,19,21,27-28H,6,13-14,16-18H2,1-5H3
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n/an/a>1.00E+3n/an/an/an/an/an/a



GALDERMA RESEARCH & DEVELOPMENT

US Patent


Assay Description
The RORγ transactivation model was developed from the line HG5LN, which is a HeLa line that stably expresses a luciferase reporter gene controll...


US Patent US10457637 (2019)

More data for this
Ligand-Target Pair
Interleukin-17A


(Homo sapiens (Human))
BDBM419227
PNG
(N-(4-ethylphenyl)-N- isobutyl-4-((R)-3- methylmorp...)
Show SMILES CCc1ccc(cc1)N(CC(C)C)S(=O)(=O)c1ccc(N2CCOC[C@H]2C)c(c1)S(C)(=N)=O
Show InChI InChI=1/C24H35N3O4S2/c1-6-20-7-9-21(10-8-20)27(16-18(2)3)33(29,30)22-11-12-23(24(15-22)32(5,25)28)26-13-14-31-17-19(26)4/h7-12,15,18-19,25H,6,13-14,16-17H2,1-5H3/t19-,32?/s2
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n/an/a>1.00E+3n/an/an/an/an/an/a



GALDERMA RESEARCH & DEVELOPMENT

US Patent


Assay Description
This model allows measurement of the effect of inhibitors on IL-17A secretion by CD4+ cells. The cells are frozen CD4+ cells (STEMCELL, #70026), isol...


US Patent US10457637 (2019)

More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma (RORC)


(Homo sapiens (Human))
BDBM419229
PNG
(N-(4-ethylphenyl)-N- isobutyl-3-(S- methylsulfonim...)
Show SMILES CCc1ccc(cc1)N(CC(C)C)S(=O)(=O)c1ccc(NC[C@H]2CNC(=O)O2)c(c1)S(C)(=N)=O
Show InChI InChI=1/C23H32N4O5S2/c1-5-17-6-8-18(9-7-17)27(15-16(2)3)34(30,31)20-10-11-21(22(12-20)33(4,24)29)25-13-19-14-26-23(28)32-19/h6-12,16,19,24-25H,5,13-15H2,1-4H3,(H,26,28)/t19-,33?/s2
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n/an/a>1.00E+3n/an/an/an/an/an/a



GALDERMA RESEARCH & DEVELOPMENT

US Patent


Assay Description
The RORγ transactivation model was developed from the line HG5LN, which is a HeLa line that stably expresses a luciferase reporter gene controll...


US Patent US10457637 (2019)

More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma (RORC)


(Homo sapiens (Human))
BDBM419249
PNG
(N-(4-ethylphenyl)-4-((R)- 3-hydroxypyrrolidin-1-yl...)
Show SMILES CCc1ccc(cc1)N(CC(C)C)S(=O)(=O)c1ccc(N2CC[C@@H](O)C2)c(c1)S(C)(=N)=O
Show InChI InChI=1/C23H33N3O4S2/c1-5-18-6-8-19(9-7-18)26(15-17(2)3)32(29,30)21-10-11-22(23(14-21)31(4,24)28)25-13-12-20(27)16-25/h6-11,14,17,20,24,27H,5,12-13,15-16H2,1-4H3/t20-,31?/s2
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n/an/a>1.00E+3n/an/an/an/an/an/a



GALDERMA RESEARCH & DEVELOPMENT

US Patent


Assay Description
The RORγ transactivation model was developed from the line HG5LN, which is a HeLa line that stably expresses a luciferase reporter gene controll...


US Patent US10457637 (2019)

More data for this
Ligand-Target Pair
Interleukin-17A


(Homo sapiens (Human))
BDBM419244
PNG
(N-(4-ethylphenyl)-N- isobutyl-4-(((4- methoxytetra...)
Show SMILES CCc1ccc(cc1)N(CC(C)C)S(=O)(=O)c1ccc(NCC2(CCOCC2)OC)c(c1)S(C)(=N)=O
Show InChI InChI=1/C26H39N3O5S2/c1-6-21-7-9-22(10-8-21)29(18-20(2)3)36(31,32)23-11-12-24(25(17-23)35(5,27)30)28-19-26(33-4)13-15-34-16-14-26/h7-12,17,20,27-28H,6,13-16,18-19H2,1-5H3
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n/an/a>1.00E+3n/an/an/an/an/an/a



GALDERMA RESEARCH & DEVELOPMENT

US Patent


Assay Description
This model allows measurement of the effect of inhibitors on IL-17A secretion by CD4+ cells. The cells are frozen CD4+ cells (STEMCELL, #70026), isol...


US Patent US10457637 (2019)

More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma (RORC)


(Homo sapiens (Human))
BDBM419137
PNG
(1,3-dioxo-4- (tetrahydropyran-4- ylmethyl)-1,2,3,4...)
Show SMILES CCc1ccc(cc1)N(CC(C)C)S(=O)(=O)c1ccc2c(c1)N(CC1CCOCC1)C(=O)CS2=O
Show InChI InChI=1/C26H34N2O5S2/c1-4-20-5-7-22(8-6-20)28(16-19(2)3)35(31,32)23-9-10-25-24(15-23)27(26(29)18-34(25)30)17-21-11-13-33-14-12-21/h5-10,15,19,21H,4,11-14,16-18H2,1-3H3
PDB

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n/an/a>1.00E+3n/an/an/an/an/an/a



GALDERMA RESEARCH & DEVELOPMENT

US Patent


Assay Description
The RORγ transactivation model was developed from the line HG5LN, which is a HeLa line that stably expresses a luciferase reporter gene controll...


US Patent US10457637 (2019)

More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma (RORC)


(Homo sapiens (Human))
BDBM419143
PNG
(3-oxo-3,4-dihydro-2H- benzo[1,4]thiazine-6- sulfon...)
Show SMILES CCc1ccc(cc1)N(CC(C)C)S(=O)(=O)c1ccc2SCC(=O)Nc2c1
Show InChI InChI=1S/C20H24N2O3S2/c1-4-15-5-7-16(8-6-15)22(12-14(2)3)27(24,25)17-9-10-19-18(11-17)21-20(23)13-26-19/h5-11,14H,4,12-13H2,1-3H3,(H,21,23)
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n/an/a>1.00E+3n/an/an/an/an/an/a



GALDERMA RESEARCH & DEVELOPMENT

US Patent


Assay Description
The RORγ transactivation model was developed from the line HG5LN, which is a HeLa line that stably expresses a luciferase reporter gene controll...


US Patent US10457637 (2019)

More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma (RORC)


(Homo sapiens (Human))
BDBM419152
PNG
(US10457637, Compound 17 | methyl 5-[(4- ethylpheny...)
Show SMILES CCc1ccc(cc1)N(CC(C)C)S(=O)(=O)c1ccc(SCC2CCOCC2)c(c1)C(=O)OC
Show InChI InChI=1S/C26H35NO5S2/c1-5-20-6-8-22(9-7-20)27(17-19(2)3)34(29,30)23-10-11-25(24(16-23)26(28)31-4)33-18-21-12-14-32-15-13-21/h6-11,16,19,21H,5,12-15,17-18H2,1-4H3
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n/an/a>1.00E+3n/an/an/an/an/an/a



GALDERMA RESEARCH & DEVELOPMENT

US Patent


Assay Description
The RORγ transactivation model was developed from the line HG5LN, which is a HeLa line that stably expresses a luciferase reporter gene controll...


US Patent US10457637 (2019)

More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma (RORC)


(Homo sapiens (Human))
BDBM50461081
PNG
(CHEMBL4228045 | US10457637, Compound 42)
Show SMILES CCc1ccc(cc1)N(CC(C)C)S(=O)(=O)c1ccc(OC2CCOCC2)c(c1)S(C)(=N)=O
Show InChI InChI=1S/C24H34N2O5S2/c1-5-19-6-8-20(9-7-19)26(17-18(2)3)33(28,29)22-10-11-23(24(16-22)32(4,25)27)31-21-12-14-30-15-13-21/h6-11,16,18,21,25H,5,12-15,17H2,1-4H3
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n/an/a>1.00E+3n/an/an/an/an/an/a



GALDERMA RESEARCH & DEVELOPMENT

US Patent


Assay Description
The RORγ transactivation model was developed from the line HG5LN, which is a HeLa line that stably expresses a luciferase reporter gene controll...


US Patent US10457637 (2019)

More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma (RORC)


(Homo sapiens (Human))
BDBM419175
PNG
(4-((2,4-difluorobenzyl)oxy)- N-(4-ethylphenyl)-N- ...)
Show SMILES CCc1ccc(cc1)N(CC(C)C)S(=O)(=O)c1ccc(OCc2ccc(F)cc2F)c(c1)S(C)(=N)=O
Show InChI InChI=1/C26H30F2N2O4S2/c1-5-19-6-10-22(11-7-19)30(16-18(2)3)36(32,33)23-12-13-25(26(15-23)35(4,29)31)34-17-20-8-9-21(27)14-24(20)28/h6-15,18,29H,5,16-17H2,1-4H3
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n/an/a>1.00E+3n/an/an/an/an/an/a



GALDERMA RESEARCH & DEVELOPMENT

US Patent


Assay Description
The RORγ transactivation model was developed from the line HG5LN, which is a HeLa line that stably expresses a luciferase reporter gene controll...


US Patent US10457637 (2019)

More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma (RORC)


(Homo sapiens (Human))
BDBM419181
PNG
(N-(4-ethylphenyl)-N- isobutyl-3-(S- methylsulfonim...)
Show SMILES CCc1ccc(cc1)N(CC(C)C)S(=O)(=O)c1ccc(OCC2CCN(CC2)S(C)(=O)=O)c(c1)S(C)(=N)=O
Show InChI InChI=1/C26H39N3O6S3/c1-6-21-7-9-23(10-8-21)29(18-20(2)3)38(33,34)24-11-12-25(26(17-24)36(4,27)30)35-19-22-13-15-28(16-14-22)37(5,31)32/h7-12,17,20,22,27H,6,13-16,18-19H2,1-5H3
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n/an/a>1.00E+3n/an/an/an/an/an/a



GALDERMA RESEARCH & DEVELOPMENT

US Patent


Assay Description
The RORγ transactivation model was developed from the line HG5LN, which is a HeLa line that stably expresses a luciferase reporter gene controll...


US Patent US10457637 (2019)

More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma (RORC)


(Homo sapiens (Human))
BDBM419198
PNG
(1-oxo-4-(tetrahydropyran-4- ylmethyl)-1,2,3,4- tet...)
Show SMILES CCc1ccc(cc1)N(CC(C)C)S(=O)(=O)c1ccc2N(CC3CCOCC3)CCS(=O)c2c1
Show InChI InChI=1/C26H36N2O4S2/c1-4-21-5-7-23(8-6-21)28(18-20(2)3)34(30,31)24-9-10-25-26(17-24)33(29)16-13-27(25)19-22-11-14-32-15-12-22/h5-10,17,20,22H,4,11-16,18-19H2,1-3H3
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n/an/a>1.00E+3n/an/an/an/an/an/a



GALDERMA RESEARCH & DEVELOPMENT

US Patent


Assay Description
The RORγ transactivation model was developed from the line HG5LN, which is a HeLa line that stably expresses a luciferase reporter gene controll...


US Patent US10457637 (2019)

More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma (RORC)


(Homo sapiens (Human))
BDBM419226
PNG
(4-(((1-acetylpyrrolidin-3- yl)methyl)amino)-N-(4- ...)
Show SMILES CCc1ccc(cc1)N(CC(C)C)S(=O)(=O)c1ccc(NCC2CCN(C2)C(C)=O)c(c1)S(C)(=N)=O
Show InChI InChI=1/C26H38N4O4S2/c1-6-21-7-9-23(10-8-21)30(17-19(2)3)36(33,34)24-11-12-25(26(15-24)35(5,27)32)28-16-22-13-14-29(18-22)20(4)31/h7-12,15,19,22,27-28H,6,13-14,16-18H2,1-5H3
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n/an/a>1.00E+3n/an/an/an/an/an/a



GALDERMA RESEARCH & DEVELOPMENT

US Patent


Assay Description
The RORγ transactivation model was developed from the line HG5LN, which is a HeLa line that stably expresses a luciferase reporter gene controll...


US Patent US10457637 (2019)

More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma (RORC)


(Homo sapiens (Human))
BDBM419134
PNG
(US10457637, Compound 1 | imino-1-oxo-4- (tetrahydr...)
Show SMILES CCc1ccc(cc1)N(CC(C)C)S(=O)(=O)c1ccc2c(c1)N(CC1CCOCC1)CCS2(=N)=O
Show InChI InChI=1/C26H37N3O4S2/c1-4-21-5-7-23(8-6-21)29(18-20(2)3)35(31,32)24-9-10-26-25(17-24)28(13-16-34(26,27)30)19-22-11-14-33-15-12-22/h5-10,17,20,22,27H,4,11-16,18-19H2,1-3H3
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n/an/a>1.00E+3n/an/an/an/an/an/a



GALDERMA RESEARCH & DEVELOPMENT

US Patent


Assay Description
The RORγ transactivation model was developed from the line HG5LN, which is a HeLa line that stably expresses a luciferase reporter gene controll...


US Patent US10457637 (2019)

More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma (RORC)


(Homo sapiens (Human))
BDBM419142
PNG
(3,4-dihydro-2H- benzo[1,4]thiazine-6- sulfonic aci...)
Show SMILES CCc1ccc(cc1)N(CC(C)C)S(=O)(=O)c1ccc2SCCNc2c1
Show InChI InChI=1S/C20H26N2O2S2/c1-4-16-5-7-17(8-6-16)22(14-15(2)3)26(23,24)18-9-10-20-19(13-18)21-11-12-25-20/h5-10,13,15,21H,4,11-12,14H2,1-3H3
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n/an/a>1.00E+3n/an/an/an/an/an/a



GALDERMA RESEARCH & DEVELOPMENT

US Patent


Assay Description
The RORγ transactivation model was developed from the line HG5LN, which is a HeLa line that stably expresses a luciferase reporter gene controll...


US Patent US10457637 (2019)

More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma (RORC)


(Homo sapiens (Human))
BDBM419176
PNG
(N-(4-ethylphenyl)-N- isobutyl-3-(S- methylsulfonim...)
Show SMILES CCc1ccc(cc1)N(CC(C)C)S(=O)(=O)c1ccc(OC2CCNCC2)c(c1)S(C)(=N)=O
Show InChI InChI=1/C24H35N3O4S2/c1-5-19-6-8-20(9-7-19)27(17-18(2)3)33(29,30)22-10-11-23(24(16-22)32(4,25)28)31-21-12-14-26-15-13-21/h6-11,16,18,21,25-26H,5,12-15,17H2,1-4H3
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n/an/a>1.00E+3n/an/an/an/an/an/a



GALDERMA RESEARCH & DEVELOPMENT

US Patent


Assay Description
The RORγ transactivation model was developed from the line HG5LN, which is a HeLa line that stably expresses a luciferase reporter gene controll...


US Patent US10457637 (2019)

More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma (RORC)


(Homo sapiens (Human))
BDBM419210
PNG
(4-((1,1-dioxidotetrahydro- 2H-thiopyran-4-yl)amino...)
Show SMILES CCc1ccc(cc1)N(CC(C)C)S(=O)(=O)c1ccc(NC2CCS(=O)(=O)CC2)c(c1)S(C)(=N)=O
Show InChI InChI=1/C24H35N3O5S3/c1-5-19-6-8-21(9-7-19)27(17-18(2)3)35(31,32)22-10-11-23(24(16-22)33(4,25)28)26-20-12-14-34(29,30)15-13-20/h6-11,16,18,20,25-26H,5,12-15,17H2,1-4H3
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n/an/a>1.00E+3n/an/an/an/an/an/a



GALDERMA RESEARCH & DEVELOPMENT

US Patent


Assay Description
The RORγ transactivation model was developed from the line HG5LN, which is a HeLa line that stably expresses a luciferase reporter gene controll...


US Patent US10457637 (2019)

More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma (RORC)


(Homo sapiens (Human))
BDBM419211
PNG
(4-(((1-acetylpiperidin-4- yl)methyl)amino)-N-(4- e...)
Show SMILES CCc1ccc(cc1)N(CC(C)C)S(=O)(=O)c1ccc(NCC2CCN(CC2)C(C)=O)c(c1)S(C)(=N)=O
Show InChI InChI=1/C27H40N4O4S2/c1-6-22-7-9-24(10-8-22)31(19-20(2)3)37(34,35)25-11-12-26(27(17-25)36(5,28)33)29-18-23-13-15-30(16-14-23)21(4)32/h7-12,17,20,23,28-29H,6,13-16,18-19H2,1-5H3
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n/an/a>1.00E+3n/an/an/an/an/an/a



GALDERMA RESEARCH & DEVELOPMENT

US Patent


Assay Description
The RORγ transactivation model was developed from the line HG5LN, which is a HeLa line that stably expresses a luciferase reporter gene controll...


US Patent US10457637 (2019)

More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma (RORC)


(Homo sapiens (Human))
BDBM419245
PNG
(4-(((3-ethyloxetan-3- yl)methyl)amino)-N-(4- ethyl...)
Show SMILES CCc1ccc(cc1)N(CC(C)C)S(=O)(=O)c1ccc(NCC2(CC)COC2)c(c1)S(C)(=N)=O
Show InChI InChI=1/C25H37N3O4S2/c1-6-20-8-10-21(11-9-20)28(15-19(3)4)34(30,31)22-12-13-23(24(14-22)33(5,26)29)27-16-25(7-2)17-32-18-25/h8-14,19,26-27H,6-7,15-18H2,1-5H3
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n/an/a>1.00E+3n/an/an/an/an/an/a



GALDERMA RESEARCH & DEVELOPMENT

US Patent


Assay Description
The RORγ transactivation model was developed from the line HG5LN, which is a HeLa line that stably expresses a luciferase reporter gene controll...


US Patent US10457637 (2019)

More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma (RORC)


(Homo sapiens (Human))
BDBM419138
PNG
(4-(tetrahydropyran-4- ylmethyl)-3,4-dihydro-2H- be...)
Show SMILES CCc1ccc(cc1)N(CC(C)C)S(=O)(=O)c1ccc2SCCN(CC3CCOCC3)c2c1
Show InChI InChI=1S/C26H36N2O3S2/c1-4-21-5-7-23(8-6-21)28(18-20(2)3)33(29,30)24-9-10-26-25(17-24)27(13-16-32-26)19-22-11-14-31-15-12-22/h5-10,17,20,22H,4,11-16,18-19H2,1-3H3
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n/an/a>1.00E+3n/an/an/an/an/an/a



GALDERMA RESEARCH & DEVELOPMENT

US Patent


Assay Description
The RORγ transactivation model was developed from the line HG5LN, which is a HeLa line that stably expresses a luciferase reporter gene controll...


US Patent US10457637 (2019)

More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma (RORC)


(Homo sapiens (Human))
BDBM419203
PNG
(1-imino-1-oxo-3- (tetrahydropyran-4- ylmethyl)-2,3...)
Show SMILES CCc1ccc(cc1)N(CC(C)C)S(=O)(=O)c1ccc2N(CC3CCOCC3)CS(=N)(=O)c2c1
Show InChI InChI=1/C25H35N3O4S2/c1-4-20-5-7-22(8-6-20)28(16-19(2)3)34(30,31)23-9-10-24-25(15-23)33(26,29)18-27(24)17-21-11-13-32-14-12-21/h5-10,15,19,21,26H,4,11-14,16-18H2,1-3H3
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n/an/a>1.00E+3n/an/an/an/an/an/a



GALDERMA RESEARCH & DEVELOPMENT

US Patent


Assay Description
The RORγ transactivation model was developed from the line HG5LN, which is a HeLa line that stably expresses a luciferase reporter gene controll...


US Patent US10457637 (2019)

More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma (RORC)


(Homo sapiens (Human))
BDBM419207
PNG
(4-(4-cyanophenoxy)-N-(4- ethylphenyl)-N-isobutyl-3...)
Show SMILES CCc1ccc(cc1)N(CC(C)C)S(=O)(=O)c1ccc(Oc2ccc(cc2)C#N)c(c1)S(C)(=N)=O
Show InChI InChI=1/C26H29N3O4S2/c1-5-20-6-10-22(11-7-20)29(18-19(2)3)35(31,32)24-14-15-25(26(16-24)34(4,28)30)33-23-12-8-21(17-27)9-13-23/h6-16,19,28H,5,18H2,1-4H3
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n/an/a>1.00E+3n/an/an/an/an/an/a



GALDERMA RESEARCH & DEVELOPMENT

US Patent


Assay Description
The RORγ transactivation model was developed from the line HG5LN, which is a HeLa line that stably expresses a luciferase reporter gene controll...


US Patent US10457637 (2019)

More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma (RORC)


(Homo sapiens (Human))
BDBM419212
PNG
(N-(4-ethylphenyl)-N- isobutyl-3-(S- methylsulfonim...)
Show SMILES CCc1ccc(cc1)N(CC(C)C)S(=O)(=O)c1ccc(NC2CCC(=O)NC2)c(c1)S(C)(=N)=O
Show InChI InChI=1/C24H34N4O4S2/c1-5-18-6-9-20(10-7-18)28(16-17(2)3)34(31,32)21-11-12-22(23(14-21)33(4,25)30)27-19-8-13-24(29)26-15-19/h6-7,9-12,14,17,19,25,27H,5,8,13,15-16H2,1-4H3,(H,26,29)
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n/an/a>1.00E+3n/an/an/an/an/an/a



GALDERMA RESEARCH & DEVELOPMENT

US Patent


Assay Description
The RORγ transactivation model was developed from the line HG5LN, which is a HeLa line that stably expresses a luciferase reporter gene controll...


US Patent US10457637 (2019)

More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma (RORC)


(Homo sapiens (Human))
BDBM419205
PNG
(N-(4-ethylphenyl)-N- isobutyl-4-((2- methoxypyridi...)
Show SMILES CCc1ccc(cc1)N(CC(C)C)S(=O)(=O)c1ccc(OCC2CCS(=O)(=O)CC2)c(c1)S(C)(=N)=O
Show InChI InChI=1/C25H36N2O6S3/c1-5-20-6-8-22(9-7-20)27(17-19(2)3)36(31,32)23-10-11-24(25(16-23)34(4,26)28)33-18-21-12-14-35(29,30)15-13-21/h6-11,16,19,21,26H,5,12-15,17-18H2,1-4H3
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n/an/a>1.00E+3n/an/an/an/an/an/a



GALDERMA RESEARCH & DEVELOPMENT

US Patent


Assay Description
The RORγ transactivation model was developed from the line HG5LN, which is a HeLa line that stably expresses a luciferase reporter gene controll...


US Patent US10457637 (2019)

More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma (RORC)


(Homo sapiens (Human))
BDBM419216
PNG
(US10457637, Compound 89 | methyl 3-(((4-(N-(4- eth...)
Show SMILES CCc1ccc(cc1)N(CC(C)C)S(=O)(=O)c1ccc(NCC2CN(C2)C(=O)OC)c(c1)S(C)(=N)=O
Show InChI InChI=1/C25H36N4O5S2/c1-6-19-7-9-21(10-8-19)29(15-18(2)3)36(32,33)22-11-12-23(24(13-22)35(5,26)31)27-14-20-16-28(17-20)25(30)34-4/h7-13,18,20,26-27H,6,14-17H2,1-5H3
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n/an/a>1.00E+3n/an/an/an/an/an/a



GALDERMA RESEARCH & DEVELOPMENT

US Patent


Assay Description
The RORγ transactivation model was developed from the line HG5LN, which is a HeLa line that stably expresses a luciferase reporter gene controll...


US Patent US10457637 (2019)

More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma (RORC)


(Homo sapiens (Human))
BDBM419223
PNG
(4-N-(4-ethylphenyl)-N- isobutyl-3-(S- methylsulfon...)
Show SMILES CCc1ccc(cc1)N(CC(C)C)S(=O)(=O)c1ccc(NCC2CCNC(=O)C2)c(c1)S(C)(=N)=O
Show InChI InChI=1/C25H36N4O4S2/c1-5-19-6-8-21(9-7-19)29(17-18(2)3)35(32,33)22-10-11-23(24(15-22)34(4,26)31)28-16-20-12-13-27-25(30)14-20/h6-11,15,18,20,26,28H,5,12-14,16-17H2,1-4H3,(H,27,30)
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n/an/a>1.00E+3n/an/an/an/an/an/a



GALDERMA RESEARCH & DEVELOPMENT

US Patent


Assay Description
The RORγ transactivation model was developed from the line HG5LN, which is a HeLa line that stably expresses a luciferase reporter gene controll...


US Patent US10457637 (2019)

More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma (RORC)


(Homo sapiens (Human))
BDBM419228
PNG
(N-(4-ethylphenyl)-N- isobutyl-3-(S- methylsulfonim...)
Show SMILES CCc1ccc(cc1)N(CC(C)C)S(=O)(=O)c1ccc(NC[C@@H]2CNC(=O)O2)c(c1)S(C)(=N)=O
Show InChI InChI=1/C23H32N4O5S2/c1-5-17-6-8-18(9-7-17)27(15-16(2)3)34(30,31)20-10-11-21(22(12-20)33(4,24)29)25-13-19-14-26-23(28)32-19/h6-12,16,19,24-25H,5,13-15H2,1-4H3,(H,26,28)/t19-,33?/s2
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n/an/a>1.00E+3n/an/an/an/an/an/a



GALDERMA RESEARCH & DEVELOPMENT

US Patent


Assay Description
The RORγ transactivation model was developed from the line HG5LN, which is a HeLa line that stably expresses a luciferase reporter gene controll...


US Patent US10457637 (2019)

More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma (RORC)


(Homo sapiens (Human))
BDBM419254
PNG
(N-(4-ethylphenyl)-N- isobutyl-3-(S- methylsulfonim...)
Show SMILES CCc1ccc(cc1)N(CC(C)C)S(=O)(=O)c1ccc(N2CCNCC2)c(c1)S(C)(=N)=O
Show InChI InChI=1/C23H34N4O3S2/c1-5-19-6-8-20(9-7-19)27(17-18(2)3)32(29,30)21-10-11-22(23(16-21)31(4,24)28)26-14-12-25-13-15-26/h6-11,16,18,24-25H,5,12-15,17H2,1-4H3
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n/an/a>1.00E+3n/an/an/an/an/an/a



GALDERMA RESEARCH & DEVELOPMENT

US Patent


Assay Description
The RORγ transactivation model was developed from the line HG5LN, which is a HeLa line that stably expresses a luciferase reporter gene controll...


US Patent US10457637 (2019)

More data for this
Ligand-Target Pair
Interleukin-17A


(Homo sapiens (Human))
BDBM419248
PNG
(N-(4-ethylphenyl)-4-((S)-3- hydroxypyrrolidin-1-yl...)
Show SMILES CCc1ccc(cc1)N(CC(C)C)S(=O)(=O)c1ccc(N2CC[C@H](O)C2)c(c1)S(C)(=N)=O
Show InChI InChI=1/C23H33N3O4S2/c1-5-18-6-8-19(9-7-18)26(15-17(2)3)32(29,30)21-10-11-22(23(14-21)31(4,24)28)25-13-12-20(27)16-25/h6-11,14,17,20,24,27H,5,12-13,15-16H2,1-4H3/t20-,31?/s2
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n/an/a>1.00E+3n/an/an/an/an/an/a



GALDERMA RESEARCH & DEVELOPMENT

US Patent


Assay Description
This model allows measurement of the effect of inhibitors on IL-17A secretion by CD4+ cells. The cells are frozen CD4+ cells (STEMCELL, #70026), isol...


US Patent US10457637 (2019)

More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma (RORC)


(Homo sapiens (Human))
BDBM419166
PNG
(N-(4-ethylphenyl)-N- isobutyl-4-((3- methyloxetan-...)
Show SMILES CCc1ccc(cc1)N(CC(C)C)S(=O)(=O)c1ccc(OCC2(C)COC2)c(c1)S(C)(=N)=O
Show InChI InChI=1/C24H34N2O5S2/c1-6-19-7-9-20(10-8-19)26(14-18(2)3)33(28,29)21-11-12-22(23(13-21)32(5,25)27)31-17-24(4)15-30-16-24/h7-13,18,25H,6,14-17H2,1-5H3
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n/an/a>1.00E+3n/an/an/an/an/an/a



GALDERMA RESEARCH & DEVELOPMENT

US Patent


Assay Description
The RORγ transactivation model was developed from the line HG5LN, which is a HeLa line that stably expresses a luciferase reporter gene controll...


US Patent US10457637 (2019)

More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma (RORC)


(Homo sapiens (Human))
BDBM419172
PNG
(4-(2,3-dihydroxypropoxy)- N-(4-ethylphenyl)-N- iso...)
Show SMILES CCc1ccc(cc1)N(CC(C)C)S(=O)(=O)c1ccc(OCC(O)CO)c(c1)S(C)(=N)=O
Show InChI InChI=1/C22H32N2O6S2/c1-5-17-6-8-18(9-7-17)24(13-16(2)3)32(28,29)20-10-11-21(30-15-19(26)14-25)22(12-20)31(4,23)27/h6-12,16,19,23,25-26H,5,13-15H2,1-4H3
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n/an/a>1.00E+3n/an/an/an/an/an/a



GALDERMA RESEARCH & DEVELOPMENT

US Patent


Assay Description
The RORγ transactivation model was developed from the line HG5LN, which is a HeLa line that stably expresses a luciferase reporter gene controll...


US Patent US10457637 (2019)

More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma (RORC)


(Homo sapiens (Human))
BDBM419186
PNG
(N-(4-ethylphenyl)-N- isobutyl-3-(S- methylsulfonim...)
Show SMILES CCc1ccc(cc1)N(CC(C)C)S(=O)(=O)c1ccc(NCC2CCC(=O)NC2)c(c1)S(C)(=N)=O
Show InChI InChI=1/C25H36N4O4S2/c1-5-19-6-9-21(10-7-19)29(17-18(2)3)35(32,33)22-11-12-23(24(14-22)34(4,26)31)27-15-20-8-13-25(30)28-16-20/h6-7,9-12,14,18,20,26-27H,5,8,13,15-17H2,1-4H3,(H,28,30)
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n/an/a>1.00E+3n/an/an/an/an/an/a



GALDERMA RESEARCH & DEVELOPMENT

US Patent


Assay Description
The RORγ transactivation model was developed from the line HG5LN, which is a HeLa line that stably expresses a luciferase reporter gene controll...


US Patent US10457637 (2019)

More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma (RORC)


(Homo sapiens (Human))
BDBM419197
PNG
(3-oxo-4-(tetrahydropyran-4- ylmethyl)-3,4-dihydro-...)
Show SMILES CCc1ccc(cc1)N(CC(C)C)S(=O)(=O)c1ccc2SCC(=O)N(CC3CCOCC3)c2c1
Show InChI InChI=1S/C26H34N2O4S2/c1-4-20-5-7-22(8-6-20)28(16-19(2)3)34(30,31)23-9-10-25-24(15-23)27(26(29)18-33-25)17-21-11-13-32-14-12-21/h5-10,15,19,21H,4,11-14,16-18H2,1-3H3
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n/an/a>1.00E+3n/an/an/an/an/an/a



GALDERMA RESEARCH & DEVELOPMENT

US Patent


Assay Description
The RORγ transactivation model was developed from the line HG5LN, which is a HeLa line that stably expresses a luciferase reporter gene controll...


US Patent US10457637 (2019)

More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma (RORC)


(Homo sapiens (Human))
BDBM419215
PNG
(N-(4-ethylphenyl)-N- isobutyl-4-(((4-methyl- 1,2,5...)
Show SMILES CCc1ccc(cc1)N(CC(C)C)S(=O)(=O)c1ccc(NCc2nonc2C)c(c1)S(C)(=N)=O
Show InChI InChI=1/C23H31N5O4S2/c1-6-18-7-9-19(10-8-18)28(15-16(2)3)34(30,31)20-11-12-21(23(13-20)33(5,24)29)25-14-22-17(4)26-32-27-22/h7-13,16,24-25H,6,14-15H2,1-5H3
PDB

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n/an/a>1.00E+3n/an/an/an/an/an/a



GALDERMA RESEARCH & DEVELOPMENT

US Patent


Assay Description
The RORγ transactivation model was developed from the line HG5LN, which is a HeLa line that stably expresses a luciferase reporter gene controll...


US Patent US10457637 (2019)

More data for this
Ligand-Target Pair
Interleukin-17A


(Homo sapiens (Human))
BDBM419250
PNG
(N-(4-ethylphenyl)-4-(3- hydroxyazetidin-1-yl)-N- i...)
Show SMILES CCc1ccc(cc1)N(CC(C)C)S(=O)(=O)c1ccc(N2CC(O)C2)c(c1)S(C)(=N)=O
Show InChI InChI=1/C22H31N3O4S2/c1-5-17-6-8-18(9-7-17)25(13-16(2)3)31(28,29)20-10-11-21(24-14-19(26)15-24)22(12-20)30(4,23)27/h6-12,16,19,23,26H,5,13-15H2,1-4H3
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n/an/a>1.00E+3n/an/an/an/an/an/a



GALDERMA RESEARCH & DEVELOPMENT

US Patent


Assay Description
This model allows measurement of the effect of inhibitors on IL-17A secretion by CD4+ cells. The cells are frozen CD4+ cells (STEMCELL, #70026), isol...


US Patent US10457637 (2019)

More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma (RORC)


(Homo sapiens (Human))
BDBM419255
PNG
(N-(4-ethylphenyl)-4-(((3- hydroxycyclobutyl)methyl...)
Show SMILES CCc1ccc(cc1)N(CC(C)C)S(=O)(=O)c1ccc(N2CCS(=O)(=O)CC2)c(c1)S(C)(=N)=O
Show InChI InChI=1/C23H33N3O5S3/c1-5-19-6-8-20(9-7-19)26(17-18(2)3)34(30,31)21-10-11-22(23(16-21)32(4,24)27)25-12-14-33(28,29)15-13-25/h6-11,16,18,24H,5,12-15,17H2,1-4H3
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n/an/a>1.00E+3n/an/an/an/an/an/a



GALDERMA RESEARCH & DEVELOPMENT

US Patent


Assay Description
The RORγ transactivation model was developed from the line HG5LN, which is a HeLa line that stably expresses a luciferase reporter gene controll...


US Patent US10457637 (2019)

More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma (RORC)


(Homo sapiens (Human))
BDBM419161
PNG
(N-(4-ethylphenyl)-N- isobutyl-4-(tetrahydropyran- ...)
Show SMILES CCc1ccc(cc1)N(CC(C)C)S(=O)(=O)c1ccc(cc1)S(=N)(=O)CC1CCOCC1
Show InChI InChI=1/C24H34N2O4S2/c1-4-20-5-7-22(8-6-20)26(17-19(2)3)32(28,29)24-11-9-23(10-12-24)31(25,27)18-21-13-15-30-16-14-21/h5-12,19,21,25H,4,13-18H2,1-3H3
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n/an/a>1.00E+3n/an/an/an/an/an/a



GALDERMA RESEARCH & DEVELOPMENT

US Patent


Assay Description
The RORγ transactivation model was developed from the line HG5LN, which is a HeLa line that stably expresses a luciferase reporter gene controll...


US Patent US10457637 (2019)

More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma (RORC)


(Homo sapiens (Human))
BDBM419164
PNG
(N-(4-eethylphenyl)-4-((3- fluorooxetan-3-yl)methox...)
Show SMILES CCc1ccc(cc1)N(CC(C)C)S(=O)(=O)c1ccc(OCC2(F)COC2)c(c1)S(C)(=N)=O
Show InChI InChI=1/C23H31FN2O5S2/c1-5-18-6-8-19(9-7-18)26(13-17(2)3)33(28,29)20-10-11-21(22(12-20)32(4,25)27)31-16-23(24)14-30-15-23/h6-12,17,25H,5,13-16H2,1-4H3
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n/an/a>1.00E+3n/an/an/an/an/an/a



GALDERMA RESEARCH & DEVELOPMENT

US Patent


Assay Description
The RORγ transactivation model was developed from the line HG5LN, which is a HeLa line that stably expresses a luciferase reporter gene controll...


US Patent US10457637 (2019)

More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma (RORC)


(Homo sapiens (Human))
BDBM419165
PNG
(US10457637, Compound 33 | tert-butyl 4-(4-(N-(4- e...)
Show SMILES CCc1ccc(cc1)N(CC(C)C)S(=O)(=O)c1ccc(OC2CCN(CC2)C(=O)OC(C)(C)C)c(c1)S(C)(=N)=O
Show InChI InChI=1/C29H43N3O6S2/c1-8-22-9-11-23(12-10-22)32(20-21(2)3)40(35,36)25-13-14-26(27(19-25)39(7,30)34)37-24-15-17-31(18-16-24)28(33)38-29(4,5)6/h9-14,19,21,24,30H,8,15-18,20H2,1-7H3
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n/an/a>1.00E+3n/an/an/an/an/an/a



GALDERMA RESEARCH & DEVELOPMENT

US Patent


Assay Description
The RORγ transactivation model was developed from the line HG5LN, which is a HeLa line that stably expresses a luciferase reporter gene controll...


US Patent US10457637 (2019)

More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma (RORC)


(Homo sapiens (Human))
BDBM419171
PNG
(N-(4-ethylphenyl)-N- isobutyl-3-(S- methylsulfonim...)
Show SMILES CCc1ccc(cc1)N(CC(C)C)S(=O)(=O)c1ccc(OCc2ccncc2)c(c1)S(C)(=N)=O
Show InChI InChI=1/C25H31N3O4S2/c1-5-20-6-8-22(9-7-20)28(17-19(2)3)34(30,31)23-10-11-24(25(16-23)33(4,26)29)32-18-21-12-14-27-15-13-21/h6-16,19,26H,5,17-18H2,1-4H3
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n/an/a>1.00E+3n/an/an/an/an/an/a



GALDERMA RESEARCH & DEVELOPMENT

US Patent


Assay Description
The RORγ transactivation model was developed from the line HG5LN, which is a HeLa line that stably expresses a luciferase reporter gene controll...


US Patent US10457637 (2019)

More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma (RORC)


(Homo sapiens (Human))
BDBM50461073
PNG
(CHEMBL4226140 | US10457637, Compound 48)
Show SMILES CCc1ccc(cc1)N(CC(C)C)S(=O)(=O)c1ccc(OC2CCN(CC2)S(C)(=O)=O)c(c1)S(C)(=N)=O
Show InChI InChI=1S/C25H37N3O6S3/c1-6-20-7-9-21(10-8-20)28(18-19(2)3)37(32,33)23-11-12-24(25(17-23)35(4,26)29)34-22-13-15-27(16-14-22)36(5,30)31/h7-12,17,19,22,26H,6,13-16,18H2,1-5H3
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n/an/a>1.00E+3n/an/an/an/an/an/a



GALDERMA RESEARCH & DEVELOPMENT

US Patent


Assay Description
The RORγ transactivation model was developed from the line HG5LN, which is a HeLa line that stably expresses a luciferase reporter gene controll...


US Patent US10457637 (2019)

More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma (RORC)


(Homo sapiens (Human))
BDBM419179
PNG
(N-(4-ethylphenyl)-N- isobutyl-3-(S- methylsulfonim...)
Show SMILES CCc1ccc(cc1)N(CC(C)C)S(=O)(=O)c1ccc(OCC2CCNCC2)c(c1)S(C)(=N)=O
Show InChI InChI=1/C25H37N3O4S2/c1-5-20-6-8-22(9-7-20)28(17-19(2)3)34(30,31)23-10-11-24(25(16-23)33(4,26)29)32-18-21-12-14-27-15-13-21/h6-11,16,19,21,26-27H,5,12-15,17-18H2,1-4H3
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n/an/a>1.00E+3n/an/an/an/an/an/a



GALDERMA RESEARCH & DEVELOPMENT

US Patent


Assay Description
The RORγ transactivation model was developed from the line HG5LN, which is a HeLa line that stably expresses a luciferase reporter gene controll...


US Patent US10457637 (2019)

More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma (RORC)


(Homo sapiens (Human))
BDBM419200
PNG
(2,2-dimethyl-3- (tetrahydropyran-4- ylmethyl)-2,3-...)
Show SMILES CCc1ccc(cc1)N(CC(C)C)S(=O)(=O)c1ccc2N(CC3CCOCC3)C(C)(C)Sc2c1
Show InChI InChI=1S/C27H38N2O3S2/c1-6-21-7-9-23(10-8-21)29(18-20(2)3)34(30,31)24-11-12-25-26(17-24)33-27(4,5)28(25)19-22-13-15-32-16-14-22/h7-12,17,20,22H,6,13-16,18-19H2,1-5H3
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n/an/a>1.00E+3n/an/an/an/an/an/a



GALDERMA RESEARCH & DEVELOPMENT

US Patent


Assay Description
The RORγ transactivation model was developed from the line HG5LN, which is a HeLa line that stably expresses a luciferase reporter gene controll...


US Patent US10457637 (2019)

More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma (RORC)


(Homo sapiens (Human))
BDBM419220
PNG
(US10457637, Compound 93 | methyl 4-(((4-(N-(4- eth...)
Show SMILES CCc1ccc(cc1)N(CC(C)C)S(=O)(=O)c1ccc(NCC2CCN(CC2)C(=O)OC)c(c1)S(C)(=N)=O
Show InChI InChI=1/C27H40N4O5S2/c1-6-21-7-9-23(10-8-21)31(19-20(2)3)38(34,35)24-11-12-25(26(17-24)37(5,28)33)29-18-22-13-15-30(16-14-22)27(32)36-4/h7-12,17,20,22,28-29H,6,13-16,18-19H2,1-5H3
PDB

UniProtKB/SwissProt
UniProtKB/TrEMBL

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UniChem
US Patent
n/an/a>1.00E+3n/an/an/an/an/an/a



GALDERMA RESEARCH & DEVELOPMENT

US Patent


Assay Description
The RORγ transactivation model was developed from the line HG5LN, which is a HeLa line that stably expresses a luciferase reporter gene controll...


US Patent US10457637 (2019)

More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma (RORC)


(Homo sapiens (Human))
BDBM419230
PNG
(N-(4-ethylphenyl)-N- isobutyl-3-(S- methylsulfonim...)
Show SMILES CCc1ccc(cc1)N(CC(C)C)S(=O)(=O)c1ccc(NC2CCNC(=O)C2)c(c1)S(C)(=N)=O
Show InChI InChI=1/C24H34N4O4S2/c1-5-18-6-8-20(9-7-18)28(16-17(2)3)34(31,32)21-10-11-22(23(15-21)33(4,25)30)27-19-12-13-26-24(29)14-19/h6-11,15,17,19,25,27H,5,12-14,16H2,1-4H3,(H,26,29)
PDB

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n/an/a>1.00E+3n/an/an/an/an/an/a



GALDERMA RESEARCH & DEVELOPMENT

US Patent


Assay Description
The RORγ transactivation model was developed from the line HG5LN, which is a HeLa line that stably expresses a luciferase reporter gene controll...


US Patent US10457637 (2019)

More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma (RORC)


(Homo sapiens (Human))
BDBM419232
PNG
(US10457637, Compound 110 | tert-butyl 6-(4-(N-(4- ...)
Show SMILES CCc1ccc(cc1)N(CC(C)C)S(=O)(=O)c1ccc(N2CC3(CN(C3)C(=O)OC(C)(C)C)C2)c(c1)S(C)(=N)=O
Show InChI InChI=1/C29H42N4O5S2/c1-8-22-9-11-23(12-10-22)33(16-21(2)3)40(36,37)24-13-14-25(26(15-24)39(7,30)35)31-17-29(18-31)19-32(20-29)27(34)38-28(4,5)6/h9-15,21,30H,8,16-20H2,1-7H3
PDB

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GoogleScholar
UniChem
US Patent
n/an/a>1.00E+3n/an/an/an/an/an/a



GALDERMA RESEARCH & DEVELOPMENT

US Patent


Assay Description
The RORγ transactivation model was developed from the line HG5LN, which is a HeLa line that stably expresses a luciferase reporter gene controll...


US Patent US10457637 (2019)

More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma (RORC)


(Homo sapiens (Human))
BDBM419239
PNG
(4-(((2H-tetrazol-5- yl)methyl)amino)-N-(4- ethylph...)
Show SMILES CCc1ccc(cc1)N(CC(C)C)S(=O)(=O)c1ccc(NCc2nn[nH]n2)c(c1)S(C)(=N)=O
Show InChI InChI=1/C21H29N7O3S2/c1-5-16-6-8-17(9-7-16)28(14-15(2)3)33(30,31)18-10-11-19(20(12-18)32(4,22)29)23-13-21-24-26-27-25-21/h6-12,15,22-23H,5,13-14H2,1-4H3,(H,24,25,26,27)
PDB

UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
UniChem
US Patent
n/an/a>1.00E+3n/an/an/an/an/an/a



GALDERMA RESEARCH & DEVELOPMENT

US Patent


Assay Description
The RORγ transactivation model was developed from the line HG5LN, which is a HeLa line that stably expresses a luciferase reporter gene controll...


US Patent US10457637 (2019)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%