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Patent code US10457654

Compile Data Set for Download or QSAR

Found 393 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM417390
PNG
(US10457654, Example 242)
Show SMILES Fc1cc(N[C@H]2CC[C@@H](C[C@@H]2N2CCCC2)c2cccc(c2)C(F)(F)F)c(Cl)cc1S(=O)(=O)Nc1ccncn1
Show InChI InChI=1S/C27H28ClF4N5O2S/c28-20-14-25(40(38,39)36-26-8-9-33-16-34-26)21(29)15-23(20)35-22-7-6-18(13-24(22)37-10-1-2-11-37)17-4-3-5-19(12-17)27(30,31)32/h3-5,8-9,12,14-16,18,22,24,35H,1-2,6-7,10-11,13H2,(H,33,34,36)/t18-,22-,24-/m0/s1
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n/an/a 0.182n/an/an/an/an/an/a



GENENTECH, INC.

US Patent


Assay Description
Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and...


US Patent US10457654 (2019)


BindingDB Entry DOI: 10.7270/Q2FR0007
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM417268
PNG
(US10457654, Example 129)
Show SMILES CN(C)[C@H]1CC(CC[C@@H]1Nc1cc(F)c(cc1Cl)S(=O)(=O)Nc1nccs1)c1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C24H25ClF4N4O2S2/c1-33(2)21-11-15(14-4-3-5-16(10-14)24(27,28)29)6-7-19(21)31-20-13-18(26)22(12-17(20)25)37(34,35)32-23-30-8-9-36-23/h3-5,8-10,12-13,15,19,21,31H,6-7,11H2,1-2H3,(H,30,32)/t15?,19-,21-/m0/s1
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n/an/a 0.255n/an/an/an/an/an/a



GENENTECH, INC.

US Patent


Assay Description
Preparation of membranes containing recombinantly expressed sodium channels: Following the procedure described in Example 243A, and making modificati...


US Patent US10457654 (2019)


BindingDB Entry DOI: 10.7270/Q2FR0007
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM417268
PNG
(US10457654, Example 129)
Show SMILES CN(C)[C@H]1CC(CC[C@@H]1Nc1cc(F)c(cc1Cl)S(=O)(=O)Nc1nccs1)c1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C24H25ClF4N4O2S2/c1-33(2)21-11-15(14-4-3-5-16(10-14)24(27,28)29)6-7-19(21)31-20-13-18(26)22(12-17(20)25)37(34,35)32-23-30-8-9-36-23/h3-5,8-10,12-13,15,19,21,31H,6-7,11H2,1-2H3,(H,30,32)/t15?,19-,21-/m0/s1
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n/an/a 0.372n/an/an/an/an/an/a



GENENTECH, INC.

US Patent


Assay Description
Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and...


US Patent US10457654 (2019)


BindingDB Entry DOI: 10.7270/Q2FR0007
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM417361
PNG
(US10457654, Example 220)
Show SMILES CN(C)[C@H]1C[C@H](CC[C@@H]1Nc1cc(F)c(cc1F)S(=O)(=O)Nc1ccncn1)c1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C25H26F5N5O2S/c1-35(2)22-11-16(15-4-3-5-17(10-15)25(28,29)30)6-7-20(22)33-21-12-19(27)23(13-18(21)26)38(36,37)34-24-8-9-31-14-32-24/h3-5,8-10,12-14,16,20,22,33H,6-7,11H2,1-2H3,(H,31,32,34)/t16-,20-,22-/m0/s1
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n/an/a 0.418n/an/an/an/an/an/a



GENENTECH, INC.

US Patent


Assay Description
Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and...


US Patent US10457654 (2019)


BindingDB Entry DOI: 10.7270/Q2FR0007
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM417390
PNG
(US10457654, Example 242)
Show SMILES Fc1cc(N[C@H]2CC[C@@H](C[C@@H]2N2CCCC2)c2cccc(c2)C(F)(F)F)c(Cl)cc1S(=O)(=O)Nc1ccncn1
Show InChI InChI=1S/C27H28ClF4N5O2S/c28-20-14-25(40(38,39)36-26-8-9-33-16-34-26)21(29)15-23(20)35-22-7-6-18(13-24(22)37-10-1-2-11-37)17-4-3-5-19(12-17)27(30,31)32/h3-5,8-9,12,14-16,18,22,24,35H,1-2,6-7,10-11,13H2,(H,33,34,36)/t18-,22-,24-/m0/s1
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n/an/a 0.428n/an/an/an/an/an/a



GENENTECH, INC.

US Patent


Assay Description
Preparation of membranes containing recombinantly expressed sodium channels: Following the procedure described in Example 243A, and making modificati...


US Patent US10457654 (2019)


BindingDB Entry DOI: 10.7270/Q2FR0007
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM417218
PNG
(US10457654, Example 87)
Show SMILES CN(C)[C@H]1CC[C@@H](C[C@@H]1Nc1cc(F)c(cc1Cl)S(=O)(=O)Nc1nccs1)c1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C24H25ClF4N4O2S2/c1-33(2)21-7-6-15(14-4-3-5-16(10-14)24(27,28)29)11-20(21)31-19-13-18(26)22(12-17(19)25)37(34,35)32-23-30-8-9-36-23/h3-5,8-10,12-13,15,20-21,31H,6-7,11H2,1-2H3,(H,30,32)/t15-,20-,21-/m0/s1
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n/an/a 0.539n/an/an/an/an/an/a



GENENTECH, INC.

US Patent


Assay Description
Preparation of membranes containing recombinantly expressed sodium channels: Frozen recombinant cell pellets were thawed on ice and diluted to 4 time...


US Patent US10457654 (2019)


BindingDB Entry DOI: 10.7270/Q2FR0007
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM417380
PNG
(US10457654, Example 236)
Show SMILES CN(C)[C@H]1C[C@H](CC[C@@H]1Nc1cc(F)c(cc1C1CCC1)S(=O)(=O)Nc1ccncn1)c1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C29H33F4N5O2S/c1-38(2)26-14-20(19-7-4-8-21(13-19)29(31,32)33)9-10-24(26)36-25-16-23(30)27(15-22(25)18-5-3-6-18)41(39,40)37-28-11-12-34-17-35-28/h4,7-8,11-13,15-18,20,24,26,36H,3,5-6,9-10,14H2,1-2H3,(H,34,35,37)/t20-,24-,26-/m0/s1
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n/an/a 0.593n/an/an/an/an/an/a



GENENTECH, INC.

US Patent


Assay Description
Preparation of membranes containing recombinantly expressed sodium channels: Following the procedure described in Example 243A, and making modificati...


US Patent US10457654 (2019)


BindingDB Entry DOI: 10.7270/Q2FR0007
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM417371
PNG
(US10457654, Example 230)
Show SMILES CN(C)[C@H]1C[C@H](CC[C@@H]1Nc1cc(F)c(cc1C1CC1)S(=O)(=O)Nc1ccncn1)c1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C28H31F4N5O2S/c1-37(2)25-13-19(18-4-3-5-20(12-18)28(30,31)32)8-9-23(25)35-24-15-22(29)26(14-21(24)17-6-7-17)40(38,39)36-27-10-11-33-16-34-27/h3-5,10-12,14-17,19,23,25,35H,6-9,13H2,1-2H3,(H,33,34,36)/t19-,23-,25-/m0/s1
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n/an/a 0.627n/an/an/an/an/an/a



GENENTECH, INC.

US Patent


Assay Description
Preparation of membranes containing recombinantly expressed sodium channels: Following the procedure described in Example 243A, and making modificati...


US Patent US10457654 (2019)


BindingDB Entry DOI: 10.7270/Q2FR0007
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM417366
PNG
(US10457654, Example 225)
Show SMILES CN(C)[C@H]1C[C@H](CC[C@@H]1Nc1cc(F)c(cc1Cl)S(=O)(=O)Nc1ccncn1)c1cccc(OC(F)(F)F)c1
Show InChI InChI=1S/C25H26ClF4N5O3S/c1-35(2)22-11-16(15-4-3-5-17(10-15)38-25(28,29)30)6-7-20(22)33-21-13-19(27)23(12-18(21)26)39(36,37)34-24-8-9-31-14-32-24/h3-5,8-10,12-14,16,20,22,33H,6-7,11H2,1-2H3,(H,31,32,34)/t16-,20-,22-/m0/s1
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n/an/a 0.643n/an/an/an/an/an/a



GENENTECH, INC.

US Patent


Assay Description
Preparation of membranes containing recombinantly expressed sodium channels: Following the procedure described in Example 243A, and making modificati...


US Patent US10457654 (2019)


BindingDB Entry DOI: 10.7270/Q2FR0007
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM417366
PNG
(US10457654, Example 225)
Show SMILES CN(C)[C@H]1C[C@H](CC[C@@H]1Nc1cc(F)c(cc1Cl)S(=O)(=O)Nc1ccncn1)c1cccc(OC(F)(F)F)c1
Show InChI InChI=1S/C25H26ClF4N5O3S/c1-35(2)22-11-16(15-4-3-5-17(10-15)38-25(28,29)30)6-7-20(22)33-21-13-19(27)23(12-18(21)26)39(36,37)34-24-8-9-31-14-32-24/h3-5,8-10,12-14,16,20,22,33H,6-7,11H2,1-2H3,(H,31,32,34)/t16-,20-,22-/m0/s1
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n/an/a 0.651n/an/an/an/an/an/a



GENENTECH, INC.

US Patent


Assay Description
Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and...


US Patent US10457654 (2019)


BindingDB Entry DOI: 10.7270/Q2FR0007
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM417368
PNG
(US10457654, Example 227)
Show SMILES CN(C)[C@H]1C[C@H](CC[C@@H]1Nc1cc(F)c(cc1Br)S(=O)(=O)Nc1ccncn1)c1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C25H26BrF4N5O2S/c1-35(2)22-11-16(15-4-3-5-17(10-15)25(28,29)30)6-7-20(22)33-21-13-19(27)23(12-18(21)26)38(36,37)34-24-8-9-31-14-32-24/h3-5,8-10,12-14,16,20,22,33H,6-7,11H2,1-2H3,(H,31,32,34)/t16-,20-,22-/m0/s1
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n/an/a 0.690n/an/an/an/an/an/a



GENENTECH, INC.

US Patent


Assay Description
Preparation of membranes containing recombinantly expressed sodium channels: Following the procedure described in Example 243A, and making modificati...


US Patent US10457654 (2019)


BindingDB Entry DOI: 10.7270/Q2FR0007
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM417321
PNG
(US10457654, Example 181)
Show SMILES CN(C)[C@H]1C[C@H](CC[C@@H]1Nc1cc(F)c(cc1Cl)S(=O)(=O)Nc1ccncn1)c1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C25H26ClF4N5O2S/c1-35(2)22-11-16(15-4-3-5-17(10-15)25(28,29)30)6-7-20(22)33-21-13-19(27)23(12-18(21)26)38(36,37)34-24-8-9-31-14-32-24/h3-5,8-10,12-14,16,20,22,33H,6-7,11H2,1-2H3,(H,31,32,34)/t16-,20-,22-/m0/s1
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n/an/a 0.783n/an/an/an/an/an/a



GENENTECH, INC.

US Patent


Assay Description
Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and...


US Patent US10457654 (2019)


BindingDB Entry DOI: 10.7270/Q2FR0007
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM417369
PNG
(US10457654, Example 228)
Show SMILES CN(C)[C@H]1C[C@H](CC[C@@H]1Nc1cc(F)c(cc1Cl)S(=O)(=O)Nc1ccon1)c1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C24H25ClF4N4O3S/c1-33(2)21-11-15(14-4-3-5-16(10-14)24(27,28)29)6-7-19(21)30-20-13-18(26)22(12-17(20)25)37(34,35)32-23-8-9-36-31-23/h3-5,8-10,12-13,15,19,21,30H,6-7,11H2,1-2H3,(H,31,32)/t15-,19-,21-/m0/s1
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n/an/a 0.846n/an/an/an/an/an/a



GENENTECH, INC.

US Patent


Assay Description
Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and...


US Patent US10457654 (2019)


BindingDB Entry DOI: 10.7270/Q2FR0007
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM417372
PNG
(US10457654, Example 231)
Show SMILES CN(C)[C@H]1C[C@H](CC[C@@H]1Nc1cc(F)c(cc1Cl)S(=O)(=O)Nc1ccncn1)c1cccc(Cl)c1
Show InChI InChI=1S/C24H26Cl2FN5O2S/c1-32(2)22-11-16(15-4-3-5-17(25)10-15)6-7-20(22)30-21-13-19(27)23(12-18(21)26)35(33,34)31-24-8-9-28-14-29-24/h3-5,8-10,12-14,16,20,22,30H,6-7,11H2,1-2H3,(H,28,29,31)/t16-,20-,22-/m0/s1
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n/an/a 0.933n/an/an/an/an/an/a



GENENTECH, INC.

US Patent


Assay Description
Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and...


US Patent US10457654 (2019)


BindingDB Entry DOI: 10.7270/Q2FR0007
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM417360
PNG
(US10457654, Example 219)
Show SMILES CN(C)[C@H]1C[C@H](CC[C@@H]1Nc1cc(F)c(cc1Cl)S(=O)(=O)Nc1ccncn1)c1cccc(c1)C1CC1
Show InChI InChI=1S/C27H31ClFN5O2S/c1-34(2)25-13-20(19-5-3-4-18(12-19)17-6-7-17)8-9-23(25)32-24-15-22(29)26(14-21(24)28)37(35,36)33-27-10-11-30-16-31-27/h3-5,10-12,14-17,20,23,25,32H,6-9,13H2,1-2H3,(H,30,31,33)/t20-,23-,25-/m0/s1
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n/an/a 0.942n/an/an/an/an/an/a



GENENTECH, INC.

US Patent


Assay Description
Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and...


US Patent US10457654 (2019)


BindingDB Entry DOI: 10.7270/Q2FR0007
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM417367
PNG
(US10457654, Example 226)
Show SMILES CN[C@H]1C[C@H](CC[C@@H]1Nc1cc(F)c(cc1Cl)S(=O)(=O)Nc1ccncn1)c1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C24H24ClF4N5O2S/c1-30-21-10-15(14-3-2-4-16(9-14)24(27,28)29)5-6-19(21)33-20-12-18(26)22(11-17(20)25)37(35,36)34-23-7-8-31-13-32-23/h2-4,7-9,11-13,15,19,21,30,33H,5-6,10H2,1H3,(H,31,32,34)/t15-,19-,21-/m0/s1
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n/an/a 1.04n/an/an/an/an/an/a



GENENTECH, INC.

US Patent


Assay Description
Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and...


US Patent US10457654 (2019)


BindingDB Entry DOI: 10.7270/Q2FR0007
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM417381
PNG
(US10457654, Example 237)
Show SMILES CN(C)[C@H]1C[C@H](CC[C@@H]1Nc1ccc(c(F)c1)S(=O)(=O)Nc1ccncn1)c1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C25H27F4N5O2S/c1-34(2)22-13-17(16-4-3-5-18(12-16)25(27,28)29)6-8-21(22)32-19-7-9-23(20(26)14-19)37(35,36)33-24-10-11-30-15-31-24/h3-5,7,9-12,14-15,17,21-22,32H,6,8,13H2,1-2H3,(H,30,31,33)/t17-,21-,22-/m0/s1
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n/an/a 1.07n/an/an/an/an/an/a



GENENTECH, INC.

US Patent


Assay Description
Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and...


US Patent US10457654 (2019)


BindingDB Entry DOI: 10.7270/Q2FR0007
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM417382
PNG
(US10457654, Example 238)
Show SMILES CN(C)[C@H]1C[C@H](CC[C@@H]1Oc1cc(F)c(cc1Cl)S(=O)(=O)Nc1ccncn1)c1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C25H25ClF4N4O3S/c1-34(2)20-11-16(15-4-3-5-17(10-15)25(28,29)30)6-7-21(20)37-22-13-19(27)23(12-18(22)26)38(35,36)33-24-8-9-31-14-32-24/h3-5,8-10,12-14,16,20-21H,6-7,11H2,1-2H3,(H,31,32,33)/t16-,20-,21-/m0/s1
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n/an/a 1.17n/an/an/an/an/an/a



GENENTECH, INC.

US Patent


Assay Description
Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and...


US Patent US10457654 (2019)


BindingDB Entry DOI: 10.7270/Q2FR0007
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM417368
PNG
(US10457654, Example 227)
Show SMILES CN(C)[C@H]1C[C@H](CC[C@@H]1Nc1cc(F)c(cc1Br)S(=O)(=O)Nc1ccncn1)c1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C25H26BrF4N5O2S/c1-35(2)22-11-16(15-4-3-5-17(10-15)25(28,29)30)6-7-20(22)33-21-13-19(27)23(12-18(21)26)38(36,37)34-24-8-9-31-14-32-24/h3-5,8-10,12-14,16,20,22,33H,6-7,11H2,1-2H3,(H,31,32,34)/t16-,20-,22-/m0/s1
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n/an/a 1.19n/an/an/an/an/an/a



GENENTECH, INC.

US Patent


Assay Description
Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and...


US Patent US10457654 (2019)


BindingDB Entry DOI: 10.7270/Q2FR0007
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM417276
PNG
(US10457654, Example 137)
Show SMILES CN(C)[C@H]1C[C@@H](CC[C@@H]1Nc1cc(F)c(cc1Cl)S(=O)(=O)Nc1nccs1)c1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C24H25ClF4N4O2S2/c1-33(2)21-11-15(14-4-3-5-16(10-14)24(27,28)29)6-7-19(21)31-20-13-18(26)22(12-17(20)25)37(34,35)32-23-30-8-9-36-23/h3-5,8-10,12-13,15,19,21,31H,6-7,11H2,1-2H3,(H,30,32)/t15-,19+,21+/m1/s1
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n/an/a 1.24n/an/an/an/an/an/a



GENENTECH, INC.

US Patent


Assay Description
Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and...


US Patent US10457654 (2019)


BindingDB Entry DOI: 10.7270/Q2FR0007
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM417321
PNG
(US10457654, Example 181)
Show SMILES CN(C)[C@H]1C[C@H](CC[C@@H]1Nc1cc(F)c(cc1Cl)S(=O)(=O)Nc1ccncn1)c1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C25H26ClF4N5O2S/c1-35(2)22-11-16(15-4-3-5-17(10-15)25(28,29)30)6-7-20(22)33-21-13-19(27)23(12-18(21)26)38(36,37)34-24-8-9-31-14-32-24/h3-5,8-10,12-14,16,20,22,33H,6-7,11H2,1-2H3,(H,31,32,34)/t16-,20-,22-/m0/s1
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n/an/a 1.31n/an/an/an/an/an/a



GENENTECH, INC.

US Patent


Assay Description
Preparation of membranes containing recombinantly expressed sodium channels: Following the procedure described in Example 243A, and making modificati...


US Patent US10457654 (2019)


BindingDB Entry DOI: 10.7270/Q2FR0007
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM417165
PNG
(US10457654, Example 39)
Show SMILES CN(C1CNC1)[C@H]1CCCC[C@@H]1Nc1cc(F)c(cc1Cl)S(=O)(=O)Nc1nccs1
Show InChI InChI=1S/C19H25ClFN5O2S2/c1-26(12-10-22-11-12)17-5-3-2-4-15(17)24-16-9-14(21)18(8-13(16)20)30(27,28)25-19-23-6-7-29-19/h6-9,12,15,17,22,24H,2-5,10-11H2,1H3,(H,23,25)/t15-,17-/m0/s1
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n/an/a 1.40n/an/an/an/an/an/a



GENENTECH, INC.

US Patent


Assay Description
Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and...


US Patent US10457654 (2019)


BindingDB Entry DOI: 10.7270/Q2FR0007
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM417335
PNG
(US10457654, Example 195)
Show SMILES CN(C)[C@@H]1C[C@@H]2[C@H](C[C@H]1Nc1cc(F)c(cc1Cl)S(=O)(=O)Nc1nccs1)C2(Cl)Cl
Show InChI InChI=1S/C18H20Cl3FN4O2S2/c1-26(2)15-6-10-9(18(10,20)21)5-14(15)24-13-8-12(22)16(7-11(13)19)30(27,28)25-17-23-3-4-29-17/h3-4,7-10,14-15,24H,5-6H2,1-2H3,(H,23,25)/t9-,10+,14+,15+/m0/s1
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n/an/a 1.40n/an/an/an/an/an/a



GENENTECH, INC.

US Patent


Assay Description
Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and...


US Patent US10457654 (2019)


BindingDB Entry DOI: 10.7270/Q2FR0007
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM417364
PNG
(US10457654, Example 223)
Show SMILES CCCc1cccc(c1)[C@H]1CC[C@H](Nc2cc(F)c(cc2Cl)S(=O)(=O)Nc2ccncn2)[C@H](C1)N(C)C
Show InChI InChI=1S/C27H33ClFN5O2S/c1-4-6-18-7-5-8-19(13-18)20-9-10-23(25(14-20)34(2)3)32-24-16-22(29)26(15-21(24)28)37(35,36)33-27-11-12-30-17-31-27/h5,7-8,11-13,15-17,20,23,25,32H,4,6,9-10,14H2,1-3H3,(H,30,31,33)/t20-,23-,25-/m0/s1
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n/an/a 1.45n/an/an/an/an/an/a



GENENTECH, INC.

US Patent


Assay Description
Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and...


US Patent US10457654 (2019)


BindingDB Entry DOI: 10.7270/Q2FR0007
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM417367
PNG
(US10457654, Example 226)
Show SMILES CN[C@H]1C[C@H](CC[C@@H]1Nc1cc(F)c(cc1Cl)S(=O)(=O)Nc1ccncn1)c1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C24H24ClF4N5O2S/c1-30-21-10-15(14-3-2-4-16(9-14)24(27,28)29)5-6-19(21)33-20-12-18(26)22(11-17(20)25)37(35,36)34-23-7-8-31-13-32-23/h2-4,7-9,11-13,15,19,21,30,33H,5-6,10H2,1H3,(H,31,32,34)/t15-,19-,21-/m0/s1
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n/an/a 1.45n/an/an/an/an/an/a



GENENTECH, INC.

US Patent


Assay Description
Preparation of membranes containing recombinantly expressed sodium channels: Following the procedure described in Example 243A, and making modificati...


US Patent US10457654 (2019)


BindingDB Entry DOI: 10.7270/Q2FR0007
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM417389
PNG
(US10457654, Example 241)
Show SMILES COc1cc(c(F)cc1N[C@H]1CC[C@@H](C[C@@H]1N(C)C)c1cccc(c1)C(F)(F)F)S(=O)(=O)Nc1ccncn1
Show InChI InChI=1S/C26H29F4N5O3S/c1-35(2)22-12-17(16-5-4-6-18(11-16)26(28,29)30)7-8-20(22)33-21-13-19(27)24(14-23(21)38-3)39(36,37)34-25-9-10-31-15-32-25/h4-6,9-11,13-15,17,20,22,33H,7-8,12H2,1-3H3,(H,31,32,34)/t17-,20-,22-/m0/s1
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n/an/a 1.48n/an/an/an/an/an/a



GENENTECH, INC.

US Patent


Assay Description
Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and...


US Patent US10457654 (2019)


BindingDB Entry DOI: 10.7270/Q2FR0007
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM417387
PNG
(US10457654, Example 239)
Show SMILES CN(C)[C@H]1C[C@H](CC[C@@H]1Oc1cc(F)c(cc1Cl)S(=O)(=O)Nc1ccncn1)c1cc(Cl)cc(Cl)c1
Show InChI InChI=1S/C24H24Cl3FN4O3S/c1-32(2)20-9-14(15-7-16(25)10-17(26)8-15)3-4-21(20)35-22-12-19(28)23(11-18(22)27)36(33,34)31-24-5-6-29-13-30-24/h5-8,10-14,20-21H,3-4,9H2,1-2H3,(H,29,30,31)/t14-,20-,21-/m0/s1
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n/an/a 1.5n/an/an/an/an/an/a



GENENTECH, INC.

US Patent


Assay Description
Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and...


US Patent US10457654 (2019)


BindingDB Entry DOI: 10.7270/Q2FR0007
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM417371
PNG
(US10457654, Example 230)
Show SMILES CN(C)[C@H]1C[C@H](CC[C@@H]1Nc1cc(F)c(cc1C1CC1)S(=O)(=O)Nc1ccncn1)c1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C28H31F4N5O2S/c1-37(2)25-13-19(18-4-3-5-20(12-18)28(30,31)32)8-9-23(25)35-24-15-22(29)26(14-21(24)17-6-7-17)40(38,39)36-27-10-11-33-16-34-27/h3-5,10-12,14-17,19,23,25,35H,6-9,13H2,1-2H3,(H,33,34,36)/t19-,23-,25-/m0/s1
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n/an/a 1.52n/an/an/an/an/an/a



GENENTECH, INC.

US Patent


Assay Description
Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and...


US Patent US10457654 (2019)


BindingDB Entry DOI: 10.7270/Q2FR0007
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM417359
PNG
(US10457654, Example 218)
Show SMILES CN(C)[C@H]1C[C@@H](CC[C@@H]1Nc1cc(F)c(cc1Cl)S(=O)(=O)Nc1ccncn1)c1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C25H26ClF4N5O2S/c1-35(2)22-11-16(15-4-3-5-17(10-15)25(28,29)30)6-7-20(22)33-21-13-19(27)23(12-18(21)26)38(36,37)34-24-8-9-31-14-32-24/h3-5,8-10,12-14,16,20,22,33H,6-7,11H2,1-2H3,(H,31,32,34)/t16-,20+,22+/m1/s1
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n/an/a 1.60n/an/an/an/an/an/a



GENENTECH, INC.

US Patent


Assay Description
Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and...


US Patent US10457654 (2019)


BindingDB Entry DOI: 10.7270/Q2FR0007
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM417380
PNG
(US10457654, Example 236)
Show SMILES CN(C)[C@H]1C[C@H](CC[C@@H]1Nc1cc(F)c(cc1C1CCC1)S(=O)(=O)Nc1ccncn1)c1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C29H33F4N5O2S/c1-38(2)26-14-20(19-7-4-8-21(13-19)29(31,32)33)9-10-24(26)36-25-16-23(30)27(15-22(25)18-5-3-6-18)41(39,40)37-28-11-12-34-17-35-28/h4,7-8,11-13,15-18,20,24,26,36H,3,5-6,9-10,14H2,1-2H3,(H,34,35,37)/t20-,24-,26-/m0/s1
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n/an/a 1.60n/an/an/an/an/an/a



GENENTECH, INC.

US Patent


Assay Description
Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and...


US Patent US10457654 (2019)


BindingDB Entry DOI: 10.7270/Q2FR0007
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM417360
PNG
(US10457654, Example 219)
Show SMILES CN(C)[C@H]1C[C@H](CC[C@@H]1Nc1cc(F)c(cc1Cl)S(=O)(=O)Nc1ccncn1)c1cccc(c1)C1CC1
Show InChI InChI=1S/C27H31ClFN5O2S/c1-34(2)25-13-20(19-5-3-4-18(12-19)17-6-7-17)8-9-23(25)32-24-15-22(29)26(14-21(24)28)37(35,36)33-27-10-11-30-16-31-27/h3-5,10-12,14-17,20,23,25,32H,6-9,13H2,1-2H3,(H,30,31,33)/t20-,23-,25-/m0/s1
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n/an/a 1.71n/an/an/an/an/an/a



GENENTECH, INC.

US Patent


Assay Description
Preparation of membranes containing recombinantly expressed sodium channels: Following the procedure described in Example 243A, and making modificati...


US Patent US10457654 (2019)


BindingDB Entry DOI: 10.7270/Q2FR0007
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM417374
PNG
(US10457654, Example 233)
Show SMILES CN(C)[C@H]1CN(CC[C@@H]1Nc1cc(F)c(cc1Cl)S(=O)(=O)Nc1ccncn1)c1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C24H25ClF4N6O2S/c1-34(2)21-13-35(16-5-3-4-15(10-16)24(27,28)29)9-7-19(21)32-20-12-18(26)22(11-17(20)25)38(36,37)33-23-6-8-30-14-31-23/h3-6,8,10-12,14,19,21,32H,7,9,13H2,1-2H3,(H,30,31,33)/t19-,21-/m0/s1
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n/an/a 1.71n/an/an/an/an/an/a



GENENTECH, INC.

US Patent


Assay Description
Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and...


US Patent US10457654 (2019)


BindingDB Entry DOI: 10.7270/Q2FR0007
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM417165
PNG
(US10457654, Example 39)
Show SMILES CN(C1CNC1)[C@H]1CCCC[C@@H]1Nc1cc(F)c(cc1Cl)S(=O)(=O)Nc1nccs1
Show InChI InChI=1S/C19H25ClFN5O2S2/c1-26(12-10-22-11-12)17-5-3-2-4-15(17)24-16-9-14(21)18(8-13(16)20)30(27,28)25-19-23-6-7-29-19/h6-9,12,15,17,22,24H,2-5,10-11H2,1H3,(H,23,25)/t15-,17-/m0/s1
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n/an/a 1.88n/an/an/an/an/an/a



GENENTECH, INC.

US Patent


Assay Description
Preparation of membranes containing recombinantly expressed sodium channels: Frozen recombinant cell pellets were thawed on ice and diluted to 4 time...


US Patent US10457654 (2019)


BindingDB Entry DOI: 10.7270/Q2FR0007
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM417189
PNG
(US10457654, Example 59)
Show SMILES CN(C)[C@H]1CC=C(C[C@@H]1Nc1cc(F)c(cc1Cl)S(=O)(=O)Nc1nccs1)c1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C24H23ClF4N4O2S2/c1-33(2)21-7-6-15(14-4-3-5-16(10-14)24(27,28)29)11-20(21)31-19-13-18(26)22(12-17(19)25)37(34,35)32-23-30-8-9-36-23/h3-6,8-10,12-13,20-21,31H,7,11H2,1-2H3,(H,30,32)/t20-,21-/m0/s1
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n/an/a 1.94n/an/an/an/an/an/a



GENENTECH, INC.

US Patent


Assay Description
Preparation of membranes containing recombinantly expressed sodium channels: Frozen recombinant cell pellets were thawed on ice and diluted to 4 time...


US Patent US10457654 (2019)


BindingDB Entry DOI: 10.7270/Q2FR0007
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM417197
PNG
(US10457654, Example 66)
Show SMILES CN(C1CNC1)[C@H]1CCCC[C@@H]1Oc1cc(F)c(cc1Cl)S(=O)(=O)Nc1nccs1
Show InChI InChI=1S/C19H24ClFN4O3S2/c1-25(12-10-22-11-12)15-4-2-3-5-16(15)28-17-9-14(21)18(8-13(17)20)30(26,27)24-19-23-6-7-29-19/h6-9,12,15-16,22H,2-5,10-11H2,1H3,(H,23,24)/t15-,16-/m0/s1
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n/an/a 2.07n/an/an/an/an/an/a



GENENTECH, INC.

US Patent


Assay Description
Preparation of membranes containing recombinantly expressed sodium channels: Frozen recombinant cell pellets were thawed on ice and diluted to 4 time...


US Patent US10457654 (2019)


BindingDB Entry DOI: 10.7270/Q2FR0007
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM417355
PNG
(US10457654, Example 214)
Show SMILES CN(C)[C@H]1C[C@H]2C[C@H]2C[C@@H]1Nc1cc(F)c(cc1Cl)S(=O)(=O)Nc1nccs1
Show InChI InChI=1S/C18H22ClFN4O2S2/c1-24(2)16-7-11-5-10(11)6-15(16)22-14-9-13(20)17(8-12(14)19)28(25,26)23-18-21-3-4-27-18/h3-4,8-11,15-16,22H,5-7H2,1-2H3,(H,21,23)/t10-,11+,15-,16-/m0/s1
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n/an/a 2.09n/an/an/an/an/an/a



GENENTECH, INC.

US Patent


Assay Description
Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and...


US Patent US10457654 (2019)


BindingDB Entry DOI: 10.7270/Q2FR0007
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM417372
PNG
(US10457654, Example 231)
Show SMILES CN(C)[C@H]1C[C@H](CC[C@@H]1Nc1cc(F)c(cc1Cl)S(=O)(=O)Nc1ccncn1)c1cccc(Cl)c1
Show InChI InChI=1S/C24H26Cl2FN5O2S/c1-32(2)22-11-16(15-4-3-5-17(25)10-15)6-7-20(22)30-21-13-19(27)23(12-18(21)26)35(33,34)31-24-8-9-28-14-29-24/h3-5,8-10,12-14,16,20,22,30H,6-7,11H2,1-2H3,(H,28,29,31)/t16-,20-,22-/m0/s1
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n/an/a 2.22n/an/an/an/an/an/a



GENENTECH, INC.

US Patent


Assay Description
Preparation of membranes containing recombinantly expressed sodium channels: Following the procedure described in Example 243A, and making modificati...


US Patent US10457654 (2019)


BindingDB Entry DOI: 10.7270/Q2FR0007
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM417300
PNG
(US10457654, Example 160)
Show SMILES Fc1cc(N[C@H]2CCCC[C@@H]2N2CC3CC3C2)c(Cl)cc1S(=O)(=O)Nc1nccs1
Show InChI InChI=1S/C20H24ClFN4O2S2/c21-14-8-19(30(27,28)25-20-23-5-6-29-20)15(22)9-17(14)24-16-3-1-2-4-18(16)26-10-12-7-13(12)11-26/h5-6,8-9,12-13,16,18,24H,1-4,7,10-11H2,(H,23,25)/t12?,13?,16-,18-/m0/s1
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n/an/a 2.27n/an/an/an/an/an/a



GENENTECH, INC.

US Patent


Assay Description
Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and...


US Patent US10457654 (2019)


BindingDB Entry DOI: 10.7270/Q2FR0007
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM417365
PNG
(US10457654, Example 224)
Show SMILES CN(C)[C@H]1C[C@H](CC[C@@H]1Nc1cc(F)c(cc1Cl)S(=O)(=O)Nc1ccncn1)c1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C25H26ClF4N5O2S/c1-35(2)22-11-16(15-3-6-17(7-4-15)25(28,29)30)5-8-20(22)33-21-13-19(27)23(12-18(21)26)38(36,37)34-24-9-10-31-14-32-24/h3-4,6-7,9-10,12-14,16,20,22,33H,5,8,11H2,1-2H3,(H,31,32,34)/t16-,20-,22-/m0/s1
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n/an/a 2.36n/an/an/an/an/an/a



GENENTECH, INC.

US Patent


Assay Description
Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and...


US Patent US10457654 (2019)


BindingDB Entry DOI: 10.7270/Q2FR0007
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM417187
PNG
(US10457654, Example 57)
Show SMILES CN(C1CNC1)[C@H]1CCCC[C@@H]1Nc1cc(F)c(cc1C1CC1)S(=O)(=O)Nc1nccs1
Show InChI InChI=1S/C22H30FN5O2S2/c1-28(15-12-24-13-15)20-5-3-2-4-18(20)26-19-11-17(23)21(10-16(19)14-6-7-14)32(29,30)27-22-25-8-9-31-22/h8-11,14-15,18,20,24,26H,2-7,12-13H2,1H3,(H,25,27)/t18-,20-/m0/s1
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n/an/a 2.42n/an/an/an/an/an/a



GENENTECH, INC.

US Patent


Assay Description
Preparation of membranes containing recombinantly expressed sodium channels: Frozen recombinant cell pellets were thawed on ice and diluted to 4 time...


US Patent US10457654 (2019)


BindingDB Entry DOI: 10.7270/Q2FR0007
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM417381
PNG
(US10457654, Example 237)
Show SMILES CN(C)[C@H]1C[C@H](CC[C@@H]1Nc1ccc(c(F)c1)S(=O)(=O)Nc1ccncn1)c1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C25H27F4N5O2S/c1-34(2)22-13-17(16-4-3-5-18(12-16)25(27,28)29)6-8-21(22)32-19-7-9-23(20(26)14-19)37(35,36)33-24-10-11-30-15-31-24/h3-5,7,9-12,14-15,17,21-22,32H,6,8,13H2,1-2H3,(H,30,31,33)/t17-,21-,22-/m0/s1
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n/an/a 2.43n/an/an/an/an/an/a



GENENTECH, INC.

US Patent


Assay Description
Preparation of membranes containing recombinantly expressed sodium channels: Following the procedure described in Example 243A, and making modificati...


US Patent US10457654 (2019)


BindingDB Entry DOI: 10.7270/Q2FR0007
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM417313
PNG
(US10457654, Example 173)
Show SMILES CN(C)[C@H]1CC[C@@H](C[C@@H]1Nc1cc(F)c(cc1Cl)S(=O)(=O)Nc1nccs1)c1ccccc1F
Show InChI InChI=1S/C23H25ClF2N4O2S2/c1-30(2)21-8-7-14(15-5-3-4-6-17(15)25)11-20(21)28-19-13-18(26)22(12-16(19)24)34(31,32)29-23-27-9-10-33-23/h3-6,9-10,12-14,20-21,28H,7-8,11H2,1-2H3,(H,27,29)/t14-,20-,21-/m0/s1
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n/an/a 2.60n/an/an/an/an/an/a



GENENTECH, INC.

US Patent


Assay Description
Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and...


US Patent US10457654 (2019)


BindingDB Entry DOI: 10.7270/Q2FR0007
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM417221
PNG
(US10457654, Example 90)
Show SMILES CN(C1CNC1)[C@H]1CCCC[C@@H]1Oc1cc(F)c(cc1C1CC1)S(=O)(=O)Nc1nccs1
Show InChI InChI=1S/C22H29FN4O3S2/c1-27(15-12-24-13-15)18-4-2-3-5-19(18)30-20-11-17(23)21(10-16(20)14-6-7-14)32(28,29)26-22-25-8-9-31-22/h8-11,14-15,18-19,24H,2-7,12-13H2,1H3,(H,25,26)/t18-,19-/m0/s1
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n/an/a 2.64n/an/an/an/an/an/a



GENENTECH, INC.

US Patent


Assay Description
Preparation of membranes containing recombinantly expressed sodium channels: Frozen recombinant cell pellets were thawed on ice and diluted to 4 time...


US Patent US10457654 (2019)


BindingDB Entry DOI: 10.7270/Q2FR0007
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM417298
PNG
(US10457654, Example 158)
Show SMILES CN(CCO)[C@H]1C[C@H](CC[C@@H]1Nc1cc(F)c(cc1Cl)S(=O)(=O)Nc1cccc(F)n1)C(F)(F)F
Show InChI InChI=1S/C21H24ClF5N4O3S/c1-31(7-8-32)17-9-12(21(25,26)27)5-6-15(17)28-16-11-14(23)18(10-13(16)22)35(33,34)30-20-4-2-3-19(24)29-20/h2-4,10-12,15,17,28,32H,5-9H2,1H3,(H,29,30)/t12-,15-,17-/m0/s1
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n/an/a 2.71n/an/an/an/an/an/a



GENENTECH, INC.

US Patent


Assay Description
Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and...


US Patent US10457654 (2019)


BindingDB Entry DOI: 10.7270/Q2FR0007
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM417163
PNG
(US10457654, Example 37)
Show SMILES CN(CCF)[C@H]1CCCC[C@@H]1Nc1cc(F)c(cc1Cl)S(=O)(=O)Nc1nccs1
Show InChI InChI=1S/C18H23ClF2N4O2S2/c1-25(8-6-20)16-5-3-2-4-14(16)23-15-11-13(21)17(10-12(15)19)29(26,27)24-18-22-7-9-28-18/h7,9-11,14,16,23H,2-6,8H2,1H3,(H,22,24)/t14-,16-/m0/s1
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n/an/a 2.76n/an/an/an/an/an/a



GENENTECH, INC.

US Patent


Assay Description
Preparation of membranes containing recombinantly expressed sodium channels: Frozen recombinant cell pellets were thawed on ice and diluted to 4 time...


US Patent US10457654 (2019)


BindingDB Entry DOI: 10.7270/Q2FR0007
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM417388
PNG
(US10457654, Example 240)
Show SMILES CN(C)[C@H]1C[C@H](CC[C@@H]1Nc1cc(F)c(cc1O)S(=O)(=O)Nc1ccncn1)c1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C25H27F4N5O3S/c1-34(2)21-11-16(15-4-3-5-17(10-15)25(27,28)29)6-7-19(21)32-20-12-18(26)23(13-22(20)35)38(36,37)33-24-8-9-30-14-31-24/h3-5,8-10,12-14,16,19,21,32,35H,6-7,11H2,1-2H3,(H,30,31,33)/t16-,19-,21-/m0/s1
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n/an/a 2.90n/an/an/an/an/an/a



GENENTECH, INC.

US Patent


Assay Description
Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and...


US Patent US10457654 (2019)


BindingDB Entry DOI: 10.7270/Q2FR0007
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM417317
PNG
(US10457654, Example 177)
Show SMILES Fc1cc(N[C@H]2CCCC[C@@H]2N2CCC[C@@H](C2)C#N)c(Cl)cc1S(=O)(=O)Nc1nccs1
Show InChI InChI=1S/C21H25ClFN5O2S2/c22-15-10-20(32(29,30)27-21-25-7-9-31-21)16(23)11-18(15)26-17-5-1-2-6-19(17)28-8-3-4-14(12-24)13-28/h7,9-11,14,17,19,26H,1-6,8,13H2,(H,25,27)/t14-,17+,19+/m1/s1
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n/an/a 2.91n/an/an/an/an/an/a



GENENTECH, INC.

US Patent


Assay Description
Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and...


US Patent US10457654 (2019)


BindingDB Entry DOI: 10.7270/Q2FR0007
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM417197
PNG
(US10457654, Example 66)
Show SMILES CN(C1CNC1)[C@H]1CCCC[C@@H]1Oc1cc(F)c(cc1Cl)S(=O)(=O)Nc1nccs1
Show InChI InChI=1S/C19H24ClFN4O3S2/c1-25(12-10-22-11-12)15-4-2-3-5-16(15)28-17-9-14(21)18(8-13(17)20)30(26,27)24-19-23-6-7-29-19/h6-9,12,15-16,22H,2-5,10-11H2,1H3,(H,23,24)/t15-,16-/m0/s1
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n/an/a 2.91n/an/an/an/an/an/a



GENENTECH, INC.

US Patent


Assay Description
Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and...


US Patent US10457654 (2019)


BindingDB Entry DOI: 10.7270/Q2FR0007
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM417310
PNG
(US10457654, Example 170)
Show SMILES CN(C1CNC1)[C@H]1C[C@H](CC[C@@H]1Nc1cc(F)c(cc1Cl)S(=O)(=O)Nc1cccc(F)n1)C(F)(F)F
Show InChI InChI=1S/C22H25ClF5N5O2S/c1-33(13-10-29-11-13)18-7-12(22(26,27)28)5-6-16(18)30-17-9-15(24)19(8-14(17)23)36(34,35)32-21-4-2-3-20(25)31-21/h2-4,8-9,12-13,16,18,29-30H,5-7,10-11H2,1H3,(H,31,32)/t12-,16-,18-/m0/s1
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n/an/a 2.92n/an/an/an/an/an/a



GENENTECH, INC.

US Patent


Assay Description
Preparation of membranes containing recombinantly expressed sodium channels: Following the procedure described in Example 243A, and making modificati...


US Patent US10457654 (2019)


BindingDB Entry DOI: 10.7270/Q2FR0007
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM417387
PNG
(US10457654, Example 239)
Show SMILES CN(C)[C@H]1C[C@H](CC[C@@H]1Oc1cc(F)c(cc1Cl)S(=O)(=O)Nc1ccncn1)c1cc(Cl)cc(Cl)c1
Show InChI InChI=1S/C24H24Cl3FN4O3S/c1-32(2)20-9-14(15-7-16(25)10-17(26)8-15)3-4-21(20)35-22-12-19(28)23(11-18(22)27)36(33,34)31-24-5-6-29-13-30-24/h5-8,10-14,20-21H,3-4,9H2,1-2H3,(H,29,30,31)/t14-,20-,21-/m0/s1
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n/an/a 2.93n/an/an/an/an/an/a



GENENTECH, INC.

US Patent


Assay Description
Preparation of membranes containing recombinantly expressed sodium channels: Following the procedure described in Example 243A, and making modificati...


US Patent US10457654 (2019)


BindingDB Entry DOI: 10.7270/Q2FR0007
More data for this
Ligand-Target Pair
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* indicates data uncertainty>20%