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Patent code US10457672

Compile Data Set for Download or QSAR
Found 128 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Wnt/beta-Catenin


(Homo sapiens (Human))
BDBM417391
PNG
(US10457672, Compound 1)
Show SMILES FC(F)(F)c1ccccc1C(=O)CCC(=O)c1ccc2OCCOc2c1
Show InChI InChI=1S/C19H15F3O4/c20-19(21,22)14-4-2-1-3-13(14)16(24)7-6-15(23)12-5-8-17-18(11-12)26-10-9-25-17/h1-5,8,11H,6-7,9-10H2
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Samumed, LLC

US Patent


Assay Description
Compounds that enhance the Wnt activity, or Activators, were assayed as follows. Reporter cell lines were generated by stably transducing cells of co...


US Patent US10457672 (2019)


BindingDB Entry DOI: 10.7270/Q26975ZV
More data for this
Ligand-Target Pair
Wnt/beta-Catenin


(Homo sapiens (Human))
BDBM417424
PNG
(US10457672, Compound 2)
Show SMILES Fc1ccccc1C(=O)CCC(=O)c1ccc2OCCOc2c1
Show InChI InChI=1S/C18H15FO4/c19-14-4-2-1-3-13(14)16(21)7-6-15(20)12-5-8-17-18(11-12)23-10-9-22-17/h1-5,8,11H,6-7,9-10H2
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Samumed, LLC

US Patent


Assay Description
Compounds that enhance the Wnt activity, or Activators, were assayed as follows. Reporter cell lines were generated by stably transducing cells of co...


US Patent US10457672 (2019)


BindingDB Entry DOI: 10.7270/Q26975ZV
More data for this
Ligand-Target Pair
Wnt/beta-Catenin


(Homo sapiens (Human))
BDBM418332
PNG
(US10457672, Compound 214)
Show SMILES Fc1cccc(c1)C(=O)CCC(=O)c1ccc2OCOc2c1
Show InChI InChI=1S/C17H13FO4/c18-13-3-1-2-11(8-13)14(19)5-6-15(20)12-4-7-16-17(9-12)22-10-21-16/h1-4,7-9H,5-6,10H2
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Samumed, LLC

US Patent


Assay Description
Compounds that enhance the Wnt activity, or Activators, were assayed as follows. Reporter cell lines were generated by stably transducing cells of co...


US Patent US10457672 (2019)


BindingDB Entry DOI: 10.7270/Q26975ZV
More data for this
Ligand-Target Pair
Wnt/beta-Catenin


(Homo sapiens (Human))
BDBM418346
PNG
(US10457672, Compound 261)
Show SMILES O=C(CCC(=O)c1ccc2[nH]ccc2c1)c1ccccc1
Show InChI InChI=1S/C18H15NO2/c20-17(13-4-2-1-3-5-13)8-9-18(21)15-6-7-16-14(12-15)10-11-19-16/h1-7,10-12,19H,8-9H2
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Samumed, LLC

US Patent


Assay Description
Compounds that enhance the Wnt activity, or Activators, were assayed as follows. Reporter cell lines were generated by stably transducing cells of co...


US Patent US10457672 (2019)


BindingDB Entry DOI: 10.7270/Q26975ZV
More data for this
Ligand-Target Pair
Wnt/beta-Catenin


(Homo sapiens (Human))
BDBM418352
PNG
(US10457672, Compound 278)
Show SMILES Fc1ccccc1C(=O)CCC(=O)c1ccc2occc2c1
Show InChI InChI=1S/C18H13FO3/c19-15-4-2-1-3-14(15)17(21)7-6-16(20)12-5-8-18-13(11-12)9-10-22-18/h1-5,8-11H,6-7H2
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Samumed, LLC

US Patent


Assay Description
Compounds that enhance the Wnt activity, or Activators, were assayed as follows. Reporter cell lines were generated by stably transducing cells of co...


US Patent US10457672 (2019)


BindingDB Entry DOI: 10.7270/Q26975ZV
More data for this
Ligand-Target Pair
Wnt/beta-Catenin


(Homo sapiens (Human))
BDBM418353
PNG
(US10457672, Compound 281)
Show SMILES COc1ccccc1C(=O)CCC(=O)c1ccc2occc2c1
Show InChI InChI=1S/C19H16O4/c1-22-19-5-3-2-4-15(19)17(21)8-7-16(20)13-6-9-18-14(12-13)10-11-23-18/h2-6,9-12H,7-8H2,1H3
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Samumed, LLC

US Patent


Assay Description
Compounds that enhance the Wnt activity, or Activators, were assayed as follows. Reporter cell lines were generated by stably transducing cells of co...


US Patent US10457672 (2019)


BindingDB Entry DOI: 10.7270/Q26975ZV
More data for this
Ligand-Target Pair
Wnt/beta-Catenin


(Homo sapiens (Human))
BDBM418357
PNG
(US10457672, Compound 292)
Show SMILES Fc1cccc(c1)C(=O)CCC(=O)c1ccc2ocnc2c1
Show InChI InChI=1S/C17H12FNO3/c18-13-3-1-2-11(8-13)15(20)5-6-16(21)12-4-7-17-14(9-12)19-10-22-17/h1-4,7-10H,5-6H2
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Samumed, LLC

US Patent


Assay Description
Compounds that enhance the Wnt activity, or Activators, were assayed as follows. Reporter cell lines were generated by stably transducing cells of co...


US Patent US10457672 (2019)


BindingDB Entry DOI: 10.7270/Q26975ZV
More data for this
Ligand-Target Pair
Wnt/beta-Catenin


(Homo sapiens (Human))
BDBM418365
PNG
(US10457672, Compound 316)
Show SMILES FC(F)(F)c1ccc(cc1)C(=O)CCC(=O)c1c[nH]c2ccccc12
Show InChI InChI=1S/C19H14F3NO2/c20-19(21,22)13-7-5-12(6-8-13)17(24)9-10-18(25)15-11-23-16-4-2-1-3-14(15)16/h1-8,11,23H,9-10H2
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Samumed, LLC

US Patent


Assay Description
Compounds that enhance the Wnt activity, or Activators, were assayed as follows. Reporter cell lines were generated by stably transducing cells of co...


US Patent US10457672 (2019)


BindingDB Entry DOI: 10.7270/Q26975ZV
More data for this
Ligand-Target Pair
Wnt/beta-Catenin


(Homo sapiens (Human))
BDBM418379
PNG
(US10457672, Compound 343)
Show SMILES Cc1cccc(c1)C(=O)CCC(=O)c1ccc2OCCOc2c1
Show InChI InChI=1S/C19H18O4/c1-13-3-2-4-14(11-13)16(20)6-7-17(21)15-5-8-18-19(12-15)23-10-9-22-18/h2-5,8,11-12H,6-7,9-10H2,1H3
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Samumed, LLC

US Patent


Assay Description
Compounds that enhance the Wnt activity, or Activators, were assayed as follows. Reporter cell lines were generated by stably transducing cells of co...


US Patent US10457672 (2019)


BindingDB Entry DOI: 10.7270/Q26975ZV
More data for this
Ligand-Target Pair
Wnt/beta-Catenin


(Homo sapiens (Human))
BDBM418383
PNG
(US10457672, Compound 358)
Show SMILES Cc1ccccc1C(=O)CCC(=O)c1ccc2OCCCc2c1
Show InChI InChI=1S/C20H20O3/c1-14-5-2-3-7-17(14)19(22)10-9-18(21)15-8-11-20-16(13-15)6-4-12-23-20/h2-3,5,7-8,11,13H,4,6,9-10,12H2,1H3
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Samumed, LLC

US Patent


Assay Description
Compounds that enhance the Wnt activity, or Activators, were assayed as follows. Reporter cell lines were generated by stably transducing cells of co...


US Patent US10457672 (2019)


BindingDB Entry DOI: 10.7270/Q26975ZV
More data for this
Ligand-Target Pair
Wnt/beta-Catenin


(Homo sapiens (Human))
BDBM418384
PNG
(US10457672, Compound 362)
Show SMILES O=C(CCC(=O)c1ncccn1)c1ccc2OCCCc2c1
Show InChI InChI=1S/C17H16N2O3/c20-14(5-6-15(21)17-18-8-2-9-19-17)12-4-7-16-13(11-12)3-1-10-22-16/h2,4,7-9,11H,1,3,5-6,10H2
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Samumed, LLC

US Patent


Assay Description
Compounds that enhance the Wnt activity, or Activators, were assayed as follows. Reporter cell lines were generated by stably transducing cells of co...


US Patent US10457672 (2019)


BindingDB Entry DOI: 10.7270/Q26975ZV
More data for this
Ligand-Target Pair
Wnt/beta-Catenin


(Homo sapiens (Human))
BDBM418387
PNG
(US10457672, Compound 368)
Show SMILES Cc1ccccc1C(=O)CCC(=O)c1ccc2OCOc2c1
Show InChI InChI=1S/C18H16O4/c1-12-4-2-3-5-14(12)16(20)8-7-15(19)13-6-9-17-18(10-13)22-11-21-17/h2-6,9-10H,7-8,11H2,1H3
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Samumed, LLC

US Patent


Assay Description
Compounds that enhance the Wnt activity, or Activators, were assayed as follows. Reporter cell lines were generated by stably transducing cells of co...


US Patent US10457672 (2019)


BindingDB Entry DOI: 10.7270/Q26975ZV
More data for this
Ligand-Target Pair
Wnt/beta-Catenin


(Homo sapiens (Human))
BDBM418388
PNG
(US10457672, Compound 372)
Show SMILES O=C(CCC(=O)c1ncccn1)c1ccc2OCOc2c1
Show InChI InChI=1S/C15H12N2O4/c18-11(3-4-12(19)15-16-6-1-7-17-15)10-2-5-13-14(8-10)21-9-20-13/h1-2,5-8H,3-4,9H2
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Samumed, LLC

US Patent


Assay Description
Compounds that enhance the Wnt activity, or Activators, were assayed as follows. Reporter cell lines were generated by stably transducing cells of co...


US Patent US10457672 (2019)


BindingDB Entry DOI: 10.7270/Q26975ZV
More data for this
Ligand-Target Pair
Wnt/beta-Catenin


(Homo sapiens (Human))
BDBM418397
PNG
(US10457672, Compound 432)
Show SMILES COc1ccc(cc1OC)C(=O)CCC(=O)c1ccncn1
Show InChI InChI=1S/C16H16N2O4/c1-21-15-6-3-11(9-16(15)22-2)13(19)4-5-14(20)12-7-8-17-10-18-12/h3,6-10H,4-5H2,1-2H3
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Samumed, LLC

US Patent


Assay Description
Compounds that enhance the Wnt activity, or Activators, were assayed as follows. Reporter cell lines were generated by stably transducing cells of co...


US Patent US10457672 (2019)


BindingDB Entry DOI: 10.7270/Q26975ZV
More data for this
Ligand-Target Pair
Wnt/beta-Catenin


(Homo sapiens (Human))
BDBM418401
PNG
(US10457672, Compound 447)
Show SMILES Cc1ccc(cc1)C(=O)CCC(=O)c1ccc2[nH]ccc2c1
Show InChI InChI=1S/C19H17NO2/c1-13-2-4-14(5-3-13)18(21)8-9-19(22)16-6-7-17-15(12-16)10-11-20-17/h2-7,10-12,20H,8-9H2,1H3
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Samumed, LLC

US Patent


Assay Description
Compounds that enhance the Wnt activity, or Activators, were assayed as follows. Reporter cell lines were generated by stably transducing cells of co...


US Patent US10457672 (2019)


BindingDB Entry DOI: 10.7270/Q26975ZV
More data for this
Ligand-Target Pair
Wnt/beta-Catenin


(Homo sapiens (Human))
BDBM418419
PNG
(US10457672, Compound 538)
Show SMILES Fc1ccccc1C(=O)CCC(=O)c1ccccn1
Show InChI InChI=1S/C15H12FNO2/c16-12-6-2-1-5-11(12)14(18)8-9-15(19)13-7-3-4-10-17-13/h1-7,10H,8-9H2
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Samumed, LLC

US Patent


Assay Description
Compounds that enhance the Wnt activity, or Activators, were assayed as follows. Reporter cell lines were generated by stably transducing cells of co...


US Patent US10457672 (2019)


BindingDB Entry DOI: 10.7270/Q26975ZV
More data for this
Ligand-Target Pair
Wnt/beta-Catenin


(Homo sapiens (Human))
BDBM418422
PNG
(US10457672, Compound 547)
Show SMILES COc1ccccc1C(=O)CCC(=O)c1ccccn1
Show InChI InChI=1S/C16H15NO3/c1-20-16-8-3-2-6-12(16)14(18)9-10-15(19)13-7-4-5-11-17-13/h2-8,11H,9-10H2,1H3
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Samumed, LLC

US Patent


Assay Description
Compounds that enhance the Wnt activity, or Activators, were assayed as follows. Reporter cell lines were generated by stably transducing cells of co...


US Patent US10457672 (2019)


BindingDB Entry DOI: 10.7270/Q26975ZV
More data for this
Ligand-Target Pair
Wnt/beta-Catenin


(Homo sapiens (Human))
BDBM418335
PNG
(US10457672, Compound 222)
Show SMILES O=C(CCC(=O)c1ccc2OCOc2c1)c1ccccc1
Show InChI InChI=1S/C17H14O4/c18-14(12-4-2-1-3-5-12)7-8-15(19)13-6-9-16-17(10-13)21-11-20-16/h1-6,9-10H,7-8,11H2
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Samumed, LLC

US Patent


Assay Description
Compounds that enhance the Wnt activity, or Activators, were assayed as follows. Reporter cell lines were generated by stably transducing cells of co...


US Patent US10457672 (2019)


BindingDB Entry DOI: 10.7270/Q26975ZV
More data for this
Ligand-Target Pair
Wnt/beta-Catenin


(Homo sapiens (Human))
BDBM418342
PNG
(US10457672, Compound 249)
Show SMILES FC(F)(F)c1ccccc1C(=O)CCC(=O)c1ccc2[nH]ccc2c1
Show InChI InChI=1S/C19H14F3NO2/c20-19(21,22)15-4-2-1-3-14(15)18(25)8-7-17(24)13-5-6-16-12(11-13)9-10-23-16/h1-6,9-11,23H,7-8H2
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Samumed, LLC

US Patent


Assay Description
Compounds that enhance the Wnt activity, or Activators, were assayed as follows. Reporter cell lines were generated by stably transducing cells of co...


US Patent US10457672 (2019)


BindingDB Entry DOI: 10.7270/Q26975ZV
More data for this
Ligand-Target Pair
Wnt/beta-Catenin


(Homo sapiens (Human))
BDBM418347
PNG
(US10457672, Compound 263)
Show SMILES FC(F)(F)c1cccc(c1)C(=O)CCC(=O)c1ccc2[nH]cnc2c1
Show InChI InChI=1S/C18H13F3N2O2/c19-18(20,21)13-3-1-2-11(8-13)16(24)6-7-17(25)12-4-5-14-15(9-12)23-10-22-14/h1-5,8-10H,6-7H2,(H,22,23)
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Samumed, LLC

US Patent


Assay Description
Compounds that enhance the Wnt activity, or Activators, were assayed as follows. Reporter cell lines were generated by stably transducing cells of co...


US Patent US10457672 (2019)


BindingDB Entry DOI: 10.7270/Q26975ZV
More data for this
Ligand-Target Pair
Wnt/beta-Catenin


(Homo sapiens (Human))
BDBM418348
PNG
(US10457672, Compound 265)
Show SMILES Fc1ccccc1C(=O)CCC(=O)c1ccc2[nH]cnc2c1
Show InChI InChI=1S/C17H13FN2O2/c18-13-4-2-1-3-12(13)17(22)8-7-16(21)11-5-6-14-15(9-11)20-10-19-14/h1-6,9-10H,7-8H2,(H,19,20)
PDB

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Samumed, LLC

US Patent


Assay Description
Compounds that enhance the Wnt activity, or Activators, were assayed as follows. Reporter cell lines were generated by stably transducing cells of co...


US Patent US10457672 (2019)


BindingDB Entry DOI: 10.7270/Q26975ZV
More data for this
Ligand-Target Pair
Wnt/beta-Catenin


(Homo sapiens (Human))
BDBM418371
PNG
(US10457672, Compound 329)
Show SMILES Fc1ccccc1C(=O)CCC(=O)c1n[nH]c2ccccc12
Show InChI InChI=1S/C17H13FN2O2/c18-13-7-3-1-5-11(13)15(21)9-10-16(22)17-12-6-2-4-8-14(12)19-20-17/h1-8H,9-10H2,(H,19,20)
PDB

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n/an/an/an/a 89n/an/an/an/a



Samumed, LLC

US Patent


Assay Description
Compounds that enhance the Wnt activity, or Activators, were assayed as follows. Reporter cell lines were generated by stably transducing cells of co...


US Patent US10457672 (2019)


BindingDB Entry DOI: 10.7270/Q26975ZV
More data for this
Ligand-Target Pair
Wnt/beta-Catenin


(Homo sapiens (Human))
BDBM418390
PNG
(US10457672, Compound 375)
Show SMILES O=C(CCC(=O)c1ccc2OCOc2c1)c1ccco1
Show InChI InChI=1S/C15H12O5/c16-11(4-5-12(17)13-2-1-7-18-13)10-3-6-14-15(8-10)20-9-19-14/h1-3,6-8H,4-5,9H2
PDB

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n/an/an/an/a 71n/an/an/an/a



Samumed, LLC

US Patent


Assay Description
Compounds that enhance the Wnt activity, or Activators, were assayed as follows. Reporter cell lines were generated by stably transducing cells of co...


US Patent US10457672 (2019)


BindingDB Entry DOI: 10.7270/Q26975ZV
More data for this
Ligand-Target Pair
Wnt/beta-Catenin


(Homo sapiens (Human))
BDBM418391
PNG
(US10457672, Compound 379)
Show SMILES Cc1cccc(c1)C(=O)CCC(=O)c1ccc2OC(F)(F)Oc2c1
Show InChI InChI=1S/C18H14F2O4/c1-11-3-2-4-12(9-11)14(21)6-7-15(22)13-5-8-16-17(10-13)24-18(19,20)23-16/h2-5,8-10H,6-7H2,1H3
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Samumed, LLC

US Patent


Assay Description
Compounds that enhance the Wnt activity, or Activators, were assayed as follows. Reporter cell lines were generated by stably transducing cells of co...


US Patent US10457672 (2019)


BindingDB Entry DOI: 10.7270/Q26975ZV
More data for this
Ligand-Target Pair
Wnt/beta-Catenin


(Homo sapiens (Human))
BDBM418404
PNG
(US10457672, Compound 456)
Show SMILES Cc1cccc(c1)C(=O)CCC(=O)c1ccc2occc2c1
Show InChI InChI=1S/C19H16O3/c1-13-3-2-4-14(11-13)17(20)6-7-18(21)15-5-8-19-16(12-15)9-10-22-19/h2-5,8-12H,6-7H2,1H3
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Samumed, LLC

US Patent


Assay Description
Compounds that enhance the Wnt activity, or Activators, were assayed as follows. Reporter cell lines were generated by stably transducing cells of co...


US Patent US10457672 (2019)


BindingDB Entry DOI: 10.7270/Q26975ZV
More data for this
Ligand-Target Pair
Wnt/beta-Catenin


(Homo sapiens (Human))
BDBM418408
PNG
(US10457672, Compound 495)
Show SMILES Fc1ccccc1C(=O)CCC(=O)c1ccc2[nH]ncc2c1
Show InChI InChI=1S/C17H13FN2O2/c18-14-4-2-1-3-13(14)17(22)8-7-16(21)11-5-6-15-12(9-11)10-19-20-15/h1-6,9-10H,7-8H2,(H,19,20)
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Samumed, LLC

US Patent


Assay Description
Compounds that enhance the Wnt activity, or Activators, were assayed as follows. Reporter cell lines were generated by stably transducing cells of co...


US Patent US10457672 (2019)


BindingDB Entry DOI: 10.7270/Q26975ZV
More data for this
Ligand-Target Pair
Wnt/beta-Catenin


(Homo sapiens (Human))
BDBM417776
PNG
(US10457672, Compound 15)
Show SMILES O=C(CCC(=O)c1ccc2OCCOc2c1)c1ccncc1
Show InChI InChI=1S/C17H15NO4/c19-14(12-5-7-18-8-6-12)2-3-15(20)13-1-4-16-17(11-13)22-10-9-21-16/h1,4-8,11H,2-3,9-10H2
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Samumed, LLC

US Patent


Assay Description
Compounds that enhance the Wnt activity, or Activators, were assayed as follows. Reporter cell lines were generated by stably transducing cells of co...


US Patent US10457672 (2019)


BindingDB Entry DOI: 10.7270/Q26975ZV
More data for this
Ligand-Target Pair
Wnt/beta-Catenin


(Homo sapiens (Human))
BDBM418321
PNG
(US10457672, Compound 61)
Show SMILES COc1ccccc1C(=O)CCC(=O)c1ccc2CCCOc2c1
Show InChI InChI=1S/C20H20O4/c1-23-19-7-3-2-6-16(19)18(22)11-10-17(21)15-9-8-14-5-4-12-24-20(14)13-15/h2-3,6-9,13H,4-5,10-12H2,1H3
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Samumed, LLC

US Patent


Assay Description
Compounds that enhance the Wnt activity, or Activators, were assayed as follows. Reporter cell lines were generated by stably transducing cells of co...


US Patent US10457672 (2019)


BindingDB Entry DOI: 10.7270/Q26975ZV
More data for this
Ligand-Target Pair
Wnt/beta-Catenin


(Homo sapiens (Human))
BDBM418323
PNG
(US10457672, Compound 69)
Show SMILES FC(F)(F)c1cccc(c1)C(=O)CCC(=O)c1ccc2OCCCc2c1
Show InChI InChI=1S/C20H17F3O3/c21-20(22,23)16-5-1-3-13(12-16)17(24)7-8-18(25)14-6-9-19-15(11-14)4-2-10-26-19/h1,3,5-6,9,11-12H,2,4,7-8,10H2
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Samumed, LLC

US Patent


Assay Description
Compounds that enhance the Wnt activity, or Activators, were assayed as follows. Reporter cell lines were generated by stably transducing cells of co...


US Patent US10457672 (2019)


BindingDB Entry DOI: 10.7270/Q26975ZV
More data for this
Ligand-Target Pair
Wnt/beta-Catenin


(Homo sapiens (Human))
BDBM418327
PNG
(US10457672, Compound 207)
Show SMILES COc1ccc(cc1OC)C(=O)CCC(=O)c1ccccn1
Show InChI InChI=1S/C17H17NO4/c1-21-16-9-6-12(11-17(16)22-2)14(19)7-8-15(20)13-5-3-4-10-18-13/h3-6,9-11H,7-8H2,1-2H3
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Samumed, LLC

US Patent


Assay Description
Compounds that enhance the Wnt activity, or Activators, were assayed as follows. Reporter cell lines were generated by stably transducing cells of co...


US Patent US10457672 (2019)


BindingDB Entry DOI: 10.7270/Q26975ZV
More data for this
Ligand-Target Pair
Wnt/beta-Catenin


(Homo sapiens (Human))
BDBM418328
PNG
(US10457672, Compound 208)
Show SMILES COc1ccc(cc1OC)C(=O)CCC(=O)c1cccnc1
Show InChI InChI=1S/C17H17NO4/c1-21-16-8-5-12(10-17(16)22-2)14(19)6-7-15(20)13-4-3-9-18-11-13/h3-5,8-11H,6-7H2,1-2H3
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Samumed, LLC

US Patent


Assay Description
Compounds that enhance the Wnt activity, or Activators, were assayed as follows. Reporter cell lines were generated by stably transducing cells of co...


US Patent US10457672 (2019)


BindingDB Entry DOI: 10.7270/Q26975ZV
More data for this
Ligand-Target Pair
Wnt/beta-Catenin


(Homo sapiens (Human))
BDBM418331
PNG
(US10457672, Compound 213)
Show SMILES Fc1ccccc1C(=O)CCC(=O)c1ccc2OCOc2c1
Show InChI InChI=1S/C17H13FO4/c18-13-4-2-1-3-12(13)15(20)7-6-14(19)11-5-8-16-17(9-11)22-10-21-16/h1-5,8-9H,6-7,10H2
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Samumed, LLC

US Patent


Assay Description
Compounds that enhance the Wnt activity, or Activators, were assayed as follows. Reporter cell lines were generated by stably transducing cells of co...


US Patent US10457672 (2019)


BindingDB Entry DOI: 10.7270/Q26975ZV
More data for this
Ligand-Target Pair
Wnt/beta-Catenin


(Homo sapiens (Human))
BDBM418337
PNG
(US10457672, Compound 235)
Show SMILES FC1(F)Oc2ccc(cc2O1)C(=O)CCC(=O)c1ccccc1
Show InChI InChI=1S/C17H12F2O4/c18-17(19)22-15-9-6-12(10-16(15)23-17)14(21)8-7-13(20)11-4-2-1-3-5-11/h1-6,9-10H,7-8H2
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Samumed, LLC

US Patent


Assay Description
Compounds that enhance the Wnt activity, or Activators, were assayed as follows. Reporter cell lines were generated by stably transducing cells of co...


US Patent US10457672 (2019)


BindingDB Entry DOI: 10.7270/Q26975ZV
More data for this
Ligand-Target Pair
Wnt/beta-Catenin


(Homo sapiens (Human))
BDBM418339
PNG
(US10457672, Compound 240)
Show SMILES Fc1cccc(c1)C(=O)CCC(=O)c1cccc2OCCOc12
Show InChI InChI=1S/C18H15FO4/c19-13-4-1-3-12(11-13)15(20)7-8-16(21)14-5-2-6-17-18(14)23-10-9-22-17/h1-6,11H,7-10H2
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Samumed, LLC

US Patent


Assay Description
Compounds that enhance the Wnt activity, or Activators, were assayed as follows. Reporter cell lines were generated by stably transducing cells of co...


US Patent US10457672 (2019)


BindingDB Entry DOI: 10.7270/Q26975ZV
More data for this
Ligand-Target Pair
Wnt/beta-Catenin


(Homo sapiens (Human))
BDBM418356
PNG
(US10457672, Compound 291)
Show SMILES Fc1ccccc1C(=O)CCC(=O)c1ccc2ocnc2c1
Show InChI InChI=1S/C17H12FNO3/c18-13-4-2-1-3-12(13)16(21)7-6-15(20)11-5-8-17-14(9-11)19-10-22-17/h1-5,8-10H,6-7H2
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Samumed, LLC

US Patent


Assay Description
Compounds that enhance the Wnt activity, or Activators, were assayed as follows. Reporter cell lines were generated by stably transducing cells of co...


US Patent US10457672 (2019)


BindingDB Entry DOI: 10.7270/Q26975ZV
More data for this
Ligand-Target Pair
Wnt/beta-Catenin


(Homo sapiens (Human))
BDBM418376
PNG
(US10457672, Compound 340)
Show SMILES O=C(CCC(=O)c1ccncn1)c1ccc2OCCOc2c1
Show InChI InChI=1S/C16H14N2O4/c19-13(2-3-14(20)12-5-6-17-10-18-12)11-1-4-15-16(9-11)22-8-7-21-15/h1,4-6,9-10H,2-3,7-8H2
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Samumed, LLC

US Patent


Assay Description
Compounds that enhance the Wnt activity, or Activators, were assayed as follows. Reporter cell lines were generated by stably transducing cells of co...


US Patent US10457672 (2019)


BindingDB Entry DOI: 10.7270/Q26975ZV
More data for this
Ligand-Target Pair
Wnt/beta-Catenin


(Homo sapiens (Human))
BDBM418377
PNG
(US10457672, Compound 341)
Show SMILES O=C(CCC(=O)c1cccnn1)c1ccc2OCCOc2c1
Show InChI InChI=1S/C16H14N2O4/c19-13(4-5-14(20)12-2-1-7-17-18-12)11-3-6-15-16(10-11)22-9-8-21-15/h1-3,6-7,10H,4-5,8-9H2
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Samumed, LLC

US Patent


Assay Description
Compounds that enhance the Wnt activity, or Activators, were assayed as follows. Reporter cell lines were generated by stably transducing cells of co...


US Patent US10457672 (2019)


BindingDB Entry DOI: 10.7270/Q26975ZV
More data for this
Ligand-Target Pair
Wnt/beta-Catenin


(Homo sapiens (Human))
BDBM418398
PNG
(US10457672, Compound 433)
Show SMILES COc1ccc(cc1OC)C(=O)CCC(=O)c1cccnn1
Show InChI InChI=1S/C16H16N2O4/c1-21-15-8-5-11(10-16(15)22-2)13(19)6-7-14(20)12-4-3-9-17-18-12/h3-5,8-10H,6-7H2,1-2H3
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Samumed, LLC

US Patent


Assay Description
Compounds that enhance the Wnt activity, or Activators, were assayed as follows. Reporter cell lines were generated by stably transducing cells of co...


US Patent US10457672 (2019)


BindingDB Entry DOI: 10.7270/Q26975ZV
More data for this
Ligand-Target Pair
Wnt/beta-Catenin


(Homo sapiens (Human))
BDBM418400
PNG
(US10457672, Compound 445)
Show SMILES Cc1ccccc1C(=O)CCC(=O)c1ccc2[nH]ccc2c1
Show InChI InChI=1S/C19H17NO2/c1-13-4-2-3-5-16(13)19(22)9-8-18(21)15-6-7-17-14(12-15)10-11-20-17/h2-7,10-12,20H,8-9H2,1H3
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Samumed, LLC

US Patent


Assay Description
Compounds that enhance the Wnt activity, or Activators, were assayed as follows. Reporter cell lines were generated by stably transducing cells of co...


US Patent US10457672 (2019)


BindingDB Entry DOI: 10.7270/Q26975ZV
More data for this
Ligand-Target Pair
Wnt/beta-Catenin


(Homo sapiens (Human))
BDBM418409
PNG
(US10457672, Compound 497)
Show SMILES Fc1ccc(cc1)C(=O)CCC(=O)c1ccc2[nH]ncc2c1
Show InChI InChI=1S/C17H13FN2O2/c18-14-4-1-11(2-5-14)16(21)7-8-17(22)12-3-6-15-13(9-12)10-19-20-15/h1-6,9-10H,7-8H2,(H,19,20)
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Samumed, LLC

US Patent


Assay Description
Compounds that enhance the Wnt activity, or Activators, were assayed as follows. Reporter cell lines were generated by stably transducing cells of co...


US Patent US10457672 (2019)


BindingDB Entry DOI: 10.7270/Q26975ZV
More data for this
Ligand-Target Pair
Wnt/beta-Catenin


(Homo sapiens (Human))
BDBM418416
PNG
(US10457672, Compound 524)
Show SMILES O=C(CCC(=O)c1c[nH]c2ccccc12)c1cccs1
Show InChI InChI=1S/C16H13NO2S/c18-14(7-8-15(19)16-6-3-9-20-16)12-10-17-13-5-2-1-4-11(12)13/h1-6,9-10,17H,7-8H2
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Samumed, LLC

US Patent


Assay Description
Compounds that enhance the Wnt activity, or Activators, were assayed as follows. Reporter cell lines were generated by stably transducing cells of co...


US Patent US10457672 (2019)


BindingDB Entry DOI: 10.7270/Q26975ZV
More data for this
Ligand-Target Pair
Wnt/beta-Catenin


(Homo sapiens (Human))
BDBM418417
PNG
(US10457672, Compound 528)
Show SMILES Cc1ccccc1C(=O)CCC(=O)c1n[nH]c2ccccc12
Show InChI InChI=1S/C18H16N2O2/c1-12-6-2-3-7-13(12)16(21)10-11-17(22)18-14-8-4-5-9-15(14)19-20-18/h2-9H,10-11H2,1H3,(H,19,20)
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Samumed, LLC

US Patent


Assay Description
Compounds that enhance the Wnt activity, or Activators, were assayed as follows. Reporter cell lines were generated by stably transducing cells of co...


US Patent US10457672 (2019)


BindingDB Entry DOI: 10.7270/Q26975ZV
More data for this
Ligand-Target Pair
Wnt/beta-Catenin


(Homo sapiens (Human))
BDBM418420
PNG
(US10457672, Compound 541)
Show SMILES FC(F)(F)c1ccccc1C(=O)CCC(=O)c1ccccn1
Show InChI InChI=1S/C16H12F3NO2/c17-16(18,19)12-6-2-1-5-11(12)14(21)8-9-15(22)13-7-3-4-10-20-13/h1-7,10H,8-9H2
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n/an/an/an/a 2.81E+3n/an/an/an/a



Samumed, LLC

US Patent


Assay Description
Compounds that enhance the Wnt activity, or Activators, were assayed as follows. Reporter cell lines were generated by stably transducing cells of co...


US Patent US10457672 (2019)


BindingDB Entry DOI: 10.7270/Q26975ZV
More data for this
Ligand-Target Pair
Wnt/beta-Catenin


(Homo sapiens (Human))
BDBM418421
PNG
(US10457672, Compound 544)
Show SMILES Cc1ccccc1C(=O)CCC(=O)c1ccccn1
Show InChI InChI=1S/C16H15NO2/c1-12-6-2-3-7-13(12)15(18)9-10-16(19)14-8-4-5-11-17-14/h2-8,11H,9-10H2,1H3
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Samumed, LLC

US Patent


Assay Description
Compounds that enhance the Wnt activity, or Activators, were assayed as follows. Reporter cell lines were generated by stably transducing cells of co...


US Patent US10457672 (2019)


BindingDB Entry DOI: 10.7270/Q26975ZV
More data for this
Ligand-Target Pair
Wnt/beta-Catenin


(Homo sapiens (Human))
BDBM418423
PNG
(US10457672, Compound 554)
Show SMILES O=C(CCC(=O)c1ccccn1)c1ccco1
Show InChI InChI=1S/C13H11NO3/c15-11(10-4-1-2-8-14-10)6-7-12(16)13-5-3-9-17-13/h1-5,8-9H,6-7H2
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Samumed, LLC

US Patent


Assay Description
Compounds that enhance the Wnt activity, or Activators, were assayed as follows. Reporter cell lines were generated by stably transducing cells of co...


US Patent US10457672 (2019)


BindingDB Entry DOI: 10.7270/Q26975ZV
More data for this
Ligand-Target Pair
Wnt/beta-Catenin


(Homo sapiens (Human))
BDBM417998
PNG
(US10457672, Compound 19)
Show SMILES Fc1ccccc1C(=O)CCC(=O)c1ccc2OCCSc2c1
Show InChI InChI=1S/C18H15FO3S/c19-14-4-2-1-3-13(14)16(21)7-6-15(20)12-5-8-17-18(11-12)23-10-9-22-17/h1-5,8,11H,6-7,9-10H2
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Samumed, LLC

US Patent


Assay Description
Compounds that enhance the Wnt activity, or Activators, were assayed as follows. Reporter cell lines were generated by stably transducing cells of co...


US Patent US10457672 (2019)


BindingDB Entry DOI: 10.7270/Q26975ZV
More data for this
Ligand-Target Pair
Wnt/beta-Catenin


(Homo sapiens (Human))
BDBM418324
PNG
(US10457672, Compound 71)
Show SMILES Fc1ccccc1C(=O)CCC(=O)c1ccc2OCCCc2c1
Show InChI InChI=1S/C19H17FO3/c20-16-6-2-1-5-15(16)18(22)9-8-17(21)13-7-10-19-14(12-13)4-3-11-23-19/h1-2,5-7,10,12H,3-4,8-9,11H2
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Samumed, LLC

US Patent


Assay Description
Compounds that enhance the Wnt activity, or Activators, were assayed as follows. Reporter cell lines were generated by stably transducing cells of co...


US Patent US10457672 (2019)


BindingDB Entry DOI: 10.7270/Q26975ZV
More data for this
Ligand-Target Pair
Wnt/beta-Catenin


(Homo sapiens (Human))
BDBM418326
PNG
(US10457672, Compound 80)
Show SMILES O=C(CCC(=O)c1ccc2OCCCc2c1)c1ccccc1
Show InChI InChI=1S/C19H18O3/c20-17(14-5-2-1-3-6-14)9-10-18(21)15-8-11-19-16(13-15)7-4-12-22-19/h1-3,5-6,8,11,13H,4,7,9-10,12H2
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Samumed, LLC

US Patent


Assay Description
Compounds that enhance the Wnt activity, or Activators, were assayed as follows. Reporter cell lines were generated by stably transducing cells of co...


US Patent US10457672 (2019)


BindingDB Entry DOI: 10.7270/Q26975ZV
More data for this
Ligand-Target Pair
Wnt/beta-Catenin


(Homo sapiens (Human))
BDBM418333
PNG
(US10457672, Compound 216)
Show SMILES COc1ccccc1C(=O)CCC(=O)c1ccc2OCOc2c1
Show InChI InChI=1S/C18H16O5/c1-21-16-5-3-2-4-13(16)15(20)8-7-14(19)12-6-9-17-18(10-12)23-11-22-17/h2-6,9-10H,7-8,11H2,1H3
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n/an/an/an/a 11n/an/an/an/a



Samumed, LLC

US Patent


Assay Description
Compounds that enhance the Wnt activity, or Activators, were assayed as follows. Reporter cell lines were generated by stably transducing cells of co...


US Patent US10457672 (2019)


BindingDB Entry DOI: 10.7270/Q26975ZV
More data for this
Ligand-Target Pair
Wnt/beta-Catenin


(Homo sapiens (Human))
BDBM418343
PNG
(US10457672, Compound 252)
Show SMILES Fc1ccccc1C(=O)CCC(=O)c1ccc2[nH]ccc2c1
Show InChI InChI=1S/C18H14FNO2/c19-15-4-2-1-3-14(15)18(22)8-7-17(21)13-5-6-16-12(11-13)9-10-20-16/h1-6,9-11,20H,7-8H2
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Samumed, LLC

US Patent


Assay Description
Compounds that enhance the Wnt activity, or Activators, were assayed as follows. Reporter cell lines were generated by stably transducing cells of co...


US Patent US10457672 (2019)


BindingDB Entry DOI: 10.7270/Q26975ZV
More data for this
Ligand-Target Pair
Wnt/beta-Catenin


(Homo sapiens (Human))
BDBM418344
PNG
(US10457672, Compound 255)
Show SMILES COc1ccccc1C(=O)CCC(=O)c1ccc2[nH]ccc2c1
Show InChI InChI=1S/C19H17NO3/c1-23-19-5-3-2-4-15(19)18(22)9-8-17(21)14-6-7-16-13(12-14)10-11-20-16/h2-7,10-12,20H,8-9H2,1H3
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Samumed, LLC

US Patent


Assay Description
Compounds that enhance the Wnt activity, or Activators, were assayed as follows. Reporter cell lines were generated by stably transducing cells of co...


US Patent US10457672 (2019)


BindingDB Entry DOI: 10.7270/Q26975ZV
More data for this
Ligand-Target Pair
Wnt/beta-Catenin


(Homo sapiens (Human))
BDBM418354
PNG
(US10457672, Compound 287)
Show SMILES O=C(CCC(=O)c1ccc2occc2c1)c1ccccc1
Show InChI InChI=1S/C18H14O3/c19-16(13-4-2-1-3-5-13)7-8-17(20)14-6-9-18-15(12-14)10-11-21-18/h1-6,9-12H,7-8H2
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n/an/an/an/a 87n/an/an/an/a



Samumed, LLC

US Patent


Assay Description
Compounds that enhance the Wnt activity, or Activators, were assayed as follows. Reporter cell lines were generated by stably transducing cells of co...


US Patent US10457672 (2019)


BindingDB Entry DOI: 10.7270/Q26975ZV
More data for this
Ligand-Target Pair
Wnt/beta-Catenin


(Homo sapiens (Human))
BDBM418358
PNG
(US10457672, Compound 294)
Show SMILES COc1ccccc1C(=O)CCC(=O)c1ccc2ocnc2c1
Show InChI InChI=1S/C18H15NO4/c1-22-17-5-3-2-4-13(17)16(21)8-7-15(20)12-6-9-18-14(10-12)19-11-23-18/h2-6,9-11H,7-8H2,1H3
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n/an/an/an/a 1.72E+3n/an/an/an/a



Samumed, LLC

US Patent


Assay Description
Compounds that enhance the Wnt activity, or Activators, were assayed as follows. Reporter cell lines were generated by stably transducing cells of co...


US Patent US10457672 (2019)


BindingDB Entry DOI: 10.7270/Q26975ZV
More data for this
Ligand-Target Pair
Wnt/beta-Catenin


(Homo sapiens (Human))
BDBM418366
PNG
(US10457672, Compound 317)
Show SMILES Fc1ccccc1C(=O)CCC(=O)c1c[nH]c2ccccc12
Show InChI InChI=1S/C18H14FNO2/c19-15-7-3-1-6-13(15)17(21)9-10-18(22)14-11-20-16-8-4-2-5-12(14)16/h1-8,11,20H,9-10H2
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Samumed, LLC

US Patent


Assay Description
Compounds that enhance the Wnt activity, or Activators, were assayed as follows. Reporter cell lines were generated by stably transducing cells of co...


US Patent US10457672 (2019)


BindingDB Entry DOI: 10.7270/Q26975ZV
More data for this
Ligand-Target Pair
Wnt/beta-Catenin


(Homo sapiens (Human))
BDBM418380
PNG
(US10457672, Compound 344)
Show SMILES Cc1ccc(cc1)C(=O)CCC(=O)c1ccc2OCCOc2c1
Show InChI InChI=1S/C19H18O4/c1-13-2-4-14(5-3-13)16(20)7-8-17(21)15-6-9-18-19(12-15)23-11-10-22-18/h2-6,9,12H,7-8,10-11H2,1H3
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Samumed, LLC

US Patent


Assay Description
Compounds that enhance the Wnt activity, or Activators, were assayed as follows. Reporter cell lines were generated by stably transducing cells of co...


US Patent US10457672 (2019)


BindingDB Entry DOI: 10.7270/Q26975ZV
More data for this
Ligand-Target Pair
Wnt/beta-Catenin


(Homo sapiens (Human))
BDBM418392
PNG
(US10457672, Compound 385)
Show SMILES FC1(F)Oc2ccc(cc2O1)C(=O)CCC(=O)c1ccco1
Show InChI InChI=1S/C15H10F2O5/c16-15(17)21-13-6-3-9(8-14(13)22-15)10(18)4-5-11(19)12-2-1-7-20-12/h1-3,6-8H,4-5H2
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Samumed, LLC

US Patent


Assay Description
Compounds that enhance the Wnt activity, or Activators, were assayed as follows. Reporter cell lines were generated by stably transducing cells of co...


US Patent US10457672 (2019)


BindingDB Entry DOI: 10.7270/Q26975ZV
More data for this
Ligand-Target Pair
Wnt/beta-Catenin


(Homo sapiens (Human))
BDBM418394
PNG
(US10457672, Compound 426)
Show SMILES COc1ccc(cc1OC)C(=O)CCC(=O)c1ccc(C)cc1
Show InChI InChI=1S/C19H20O4/c1-13-4-6-14(7-5-13)16(20)9-10-17(21)15-8-11-18(22-2)19(12-15)23-3/h4-8,11-12H,9-10H2,1-3H3
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n/an/an/an/a 8.80E+3n/an/an/an/a



Samumed, LLC

US Patent


Assay Description
Compounds that enhance the Wnt activity, or Activators, were assayed as follows. Reporter cell lines were generated by stably transducing cells of co...


US Patent US10457672 (2019)


BindingDB Entry DOI: 10.7270/Q26975ZV
More data for this
Ligand-Target Pair
Wnt/beta-Catenin


(Homo sapiens (Human))
BDBM418402
PNG
(US10457672, Compound 451)
Show SMILES O=C(CCC(=O)c1ccc2[nH]ccc2c1)c1cccs1
Show InChI InChI=1S/C16H13NO2S/c18-14(5-6-15(19)16-2-1-9-20-16)12-3-4-13-11(10-12)7-8-17-13/h1-4,7-10,17H,5-6H2
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Samumed, LLC

US Patent


Assay Description
Compounds that enhance the Wnt activity, or Activators, were assayed as follows. Reporter cell lines were generated by stably transducing cells of co...


US Patent US10457672 (2019)


BindingDB Entry DOI: 10.7270/Q26975ZV
More data for this
Ligand-Target Pair
Wnt/beta-Catenin


(Homo sapiens (Human))
BDBM418407
PNG
(US10457672, Compound 485)
Show SMILES Cc1ccccc1C(=O)CCC(=O)c1ccc2ocnc2c1
Show InChI InChI=1S/C18H15NO3/c1-12-4-2-3-5-14(12)17(21)8-7-16(20)13-6-9-18-15(10-13)19-11-22-18/h2-6,9-11H,7-8H2,1H3
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Samumed, LLC

US Patent


Assay Description
Compounds that enhance the Wnt activity, or Activators, were assayed as follows. Reporter cell lines were generated by stably transducing cells of co...


US Patent US10457672 (2019)


BindingDB Entry DOI: 10.7270/Q26975ZV
More data for this
Ligand-Target Pair
Wnt/beta-Catenin


(Homo sapiens (Human))
BDBM418412
PNG
(US10457672, Compound 507)
Show SMILES O=C(CCC(=O)c1ccccn1)c1ccc2[nH]ncc2c1
Show InChI InChI=1S/C16H13N3O2/c20-15(6-7-16(21)14-3-1-2-8-17-14)11-4-5-13-12(9-11)10-18-19-13/h1-5,8-10H,6-7H2,(H,18,19)
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Samumed, LLC

US Patent


Assay Description
Compounds that enhance the Wnt activity, or Activators, were assayed as follows. Reporter cell lines were generated by stably transducing cells of co...


US Patent US10457672 (2019)


BindingDB Entry DOI: 10.7270/Q26975ZV
More data for this
Ligand-Target Pair
Wnt/beta-Catenin


(Homo sapiens (Human))
BDBM418415
PNG
(US10457672, Compound 518)
Show SMILES Cc1ccccc1C(=O)CCC(=O)c1c[nH]c2ccccc12
Show InChI InChI=1S/C19H17NO2/c1-13-6-2-3-7-14(13)18(21)10-11-19(22)16-12-20-17-9-5-4-8-15(16)17/h2-9,12,20H,10-11H2,1H3
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Samumed, LLC

US Patent


Assay Description
Compounds that enhance the Wnt activity, or Activators, were assayed as follows. Reporter cell lines were generated by stably transducing cells of co...


US Patent US10457672 (2019)


BindingDB Entry DOI: 10.7270/Q26975ZV
More data for this
Ligand-Target Pair
Wnt/beta-Catenin


(Homo sapiens (Human))
BDBM418418
PNG
(US10457672, Compound 529)
Show SMILES Cc1cccc(c1)C(=O)CCC(=O)c1n[nH]c2ccccc12
Show InChI InChI=1S/C18H16N2O2/c1-12-5-4-6-13(11-12)16(21)9-10-17(22)18-14-7-2-3-8-15(14)19-20-18/h2-8,11H,9-10H2,1H3,(H,19,20)
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n/an/an/an/a 695n/an/an/an/a



Samumed, LLC

US Patent


Assay Description
Compounds that enhance the Wnt activity, or Activators, were assayed as follows. Reporter cell lines were generated by stably transducing cells of co...


US Patent US10457672 (2019)


BindingDB Entry DOI: 10.7270/Q26975ZV
More data for this
Ligand-Target Pair
Wnt/beta-Catenin


(Homo sapiens (Human))
BDBM418424
PNG
(US10457672, Compound 557)
Show SMILES Fc1ccccc1C(=O)CCC(=O)c1cccs1
Show InChI InChI=1S/C14H11FO2S/c15-11-5-2-1-4-10(11)12(16)7-8-13(17)14-6-3-9-18-14/h1-6,9H,7-8H2
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Samumed, LLC

US Patent


Assay Description
Compounds that enhance the Wnt activity, or Activators, were assayed as follows. Reporter cell lines were generated by stably transducing cells of co...


US Patent US10457672 (2019)


BindingDB Entry DOI: 10.7270/Q26975ZV
More data for this
Ligand-Target Pair
Wnt/beta-Catenin


(Homo sapiens (Human))
BDBM418432
PNG
(US10457672, Compound 767)
Show SMILES Clc1cccnc1C(=O)CCC(=O)c1ccc2OCCOc2c1
Show InChI InChI=1S/C17H14ClNO4/c18-12-2-1-7-19-17(12)14(21)5-4-13(20)11-3-6-15-16(10-11)23-9-8-22-15/h1-3,6-7,10H,4-5,8-9H2
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Samumed, LLC

US Patent


Assay Description
Compounds that enhance the Wnt activity, or Activators, were assayed as follows. Reporter cell lines were generated by stably transducing cells of co...


US Patent US10457672 (2019)


BindingDB Entry DOI: 10.7270/Q26975ZV
More data for this
Ligand-Target Pair
Wnt/beta-Catenin


(Homo sapiens (Human))
BDBM417489
PNG
(US10457672, Compound 9)
Show SMILES FC(F)(F)c1cccc(c1)C(=O)CCC(=O)c1ccc2OCCOc2c1
Show InChI InChI=1S/C19H15F3O4/c20-19(21,22)14-3-1-2-12(10-14)15(23)5-6-16(24)13-4-7-17-18(11-13)26-9-8-25-17/h1-4,7,10-11H,5-6,8-9H2
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n/an/an/an/a 100n/an/an/an/a



Samumed, LLC

US Patent


Assay Description
Compounds that enhance the Wnt activity, or Activators, were assayed as follows. Reporter cell lines were generated by stably transducing cells of co...


US Patent US10457672 (2019)


BindingDB Entry DOI: 10.7270/Q26975ZV
More data for this
Ligand-Target Pair
Wnt/beta-Catenin


(Homo sapiens (Human))
BDBM417514
PNG
(US10457672, Compound 11)
Show SMILES Fc1cccc(c1)C(=O)CCC(=O)c1ccc2OCCOc2c1
Show InChI InChI=1S/C18H15FO4/c19-14-3-1-2-12(10-14)15(20)5-6-16(21)13-4-7-17-18(11-13)23-9-8-22-17/h1-4,7,10-11H,5-6,8-9H2
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n/an/an/an/a 13n/an/an/an/a



Samumed, LLC

US Patent


Assay Description
Compounds that enhance the Wnt activity, or Activators, were assayed as follows. Reporter cell lines were generated by stably transducing cells of co...


US Patent US10457672 (2019)


BindingDB Entry DOI: 10.7270/Q26975ZV
More data for this
Ligand-Target Pair
Wnt/beta-Catenin


(Homo sapiens (Human))
BDBM418061
PNG
(US10457672, Compound 28)
Show SMILES O=C(CCC(=O)c1ccc2OCCSc2c1)c1ccccc1
Show InChI InChI=1S/C18H16O3S/c19-15(13-4-2-1-3-5-13)7-8-16(20)14-6-9-17-18(12-14)22-11-10-21-17/h1-6,9,12H,7-8,10-11H2
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Samumed, LLC

US Patent


Assay Description
Compounds that enhance the Wnt activity, or Activators, were assayed as follows. Reporter cell lines were generated by stably transducing cells of co...


US Patent US10457672 (2019)


BindingDB Entry DOI: 10.7270/Q26975ZV
More data for this
Ligand-Target Pair
Wnt/beta-Catenin


(Homo sapiens (Human))
BDBM418330
PNG
(US10457672, Compound 210)
Show SMILES FC(F)(F)c1ccccc1C(=O)CCC(=O)c1ccc2OCOc2c1
Show InChI InChI=1S/C18H13F3O4/c19-18(20,21)13-4-2-1-3-12(13)15(23)7-6-14(22)11-5-8-16-17(9-11)25-10-24-16/h1-5,8-9H,6-7,10H2
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Samumed, LLC

US Patent


Assay Description
Compounds that enhance the Wnt activity, or Activators, were assayed as follows. Reporter cell lines were generated by stably transducing cells of co...


US Patent US10457672 (2019)


BindingDB Entry DOI: 10.7270/Q26975ZV
More data for this
Ligand-Target Pair
Wnt/beta-Catenin


(Homo sapiens (Human))
BDBM418336
PNG
(US10457672, Compound 232)
Show SMILES FC1(F)Oc2ccc(cc2O1)C(=O)CCC(=O)c1ccccn1
Show InChI InChI=1S/C16H11F2NO4/c17-16(18)22-14-7-4-10(9-15(14)23-16)12(20)5-6-13(21)11-3-1-2-8-19-11/h1-4,7-9H,5-6H2
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Samumed, LLC

US Patent


Assay Description
Compounds that enhance the Wnt activity, or Activators, were assayed as follows. Reporter cell lines were generated by stably transducing cells of co...


US Patent US10457672 (2019)


BindingDB Entry DOI: 10.7270/Q26975ZV
More data for this
Ligand-Target Pair
Wnt/beta-Catenin


(Homo sapiens (Human))
BDBM418340
PNG
(US10457672, Compound 242)
Show SMILES COc1ccccc1C(=O)CCC(=O)c1cccc2OCCOc12
Show InChI InChI=1S/C19H18O5/c1-22-17-7-3-2-5-13(17)15(20)9-10-16(21)14-6-4-8-18-19(14)24-12-11-23-18/h2-8H,9-12H2,1H3
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Samumed, LLC

US Patent


Assay Description
Compounds that enhance the Wnt activity, or Activators, were assayed as follows. Reporter cell lines were generated by stably transducing cells of co...


US Patent US10457672 (2019)


BindingDB Entry DOI: 10.7270/Q26975ZV
More data for this
Ligand-Target Pair
Wnt/beta-Catenin


(Homo sapiens (Human))
BDBM418381
PNG
(US10457672, Compound 345)
Show SMILES O=C(CCC(=O)c1cncnc1)c1ccc2OCCOc2c1
Show InChI InChI=1S/C16H14N2O4/c19-13(2-3-14(20)12-8-17-10-18-9-12)11-1-4-15-16(7-11)22-6-5-21-15/h1,4,7-10H,2-3,5-6H2
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Samumed, LLC

US Patent


Assay Description
Compounds that enhance the Wnt activity, or Activators, were assayed as follows. Reporter cell lines were generated by stably transducing cells of co...


US Patent US10457672 (2019)


BindingDB Entry DOI: 10.7270/Q26975ZV
More data for this
Ligand-Target Pair
Wnt/beta-Catenin


(Homo sapiens (Human))
BDBM418395
PNG
(US10457672, Compound 430)
Show SMILES COc1ccc(cc1OC)C(=O)CCC(=O)c1cncnc1
Show InChI InChI=1S/C16H16N2O4/c1-21-15-6-3-11(7-16(15)22-2)13(19)4-5-14(20)12-8-17-10-18-9-12/h3,6-10H,4-5H2,1-2H3
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Samumed, LLC

US Patent


Assay Description
Compounds that enhance the Wnt activity, or Activators, were assayed as follows. Reporter cell lines were generated by stably transducing cells of co...


US Patent US10457672 (2019)


BindingDB Entry DOI: 10.7270/Q26975ZV
More data for this
Ligand-Target Pair
Wnt/beta-Catenin


(Homo sapiens (Human))
BDBM418406
PNG
(US10457672, Compound 462)
Show SMILES O=C(CCC(=O)c1ccc2occc2c1)c1ccco1
Show InChI InChI=1S/C16H12O4/c17-13(4-5-14(18)16-2-1-8-19-16)11-3-6-15-12(10-11)7-9-20-15/h1-3,6-10H,4-5H2
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n/an/an/an/a 424n/an/an/an/a



Samumed, LLC

US Patent


Assay Description
Compounds that enhance the Wnt activity, or Activators, were assayed as follows. Reporter cell lines were generated by stably transducing cells of co...


US Patent US10457672 (2019)


BindingDB Entry DOI: 10.7270/Q26975ZV
More data for this
Ligand-Target Pair
Wnt/beta-Catenin


(Homo sapiens (Human))
BDBM418414
PNG
(US10457672, Compound 515)
Show SMILES O=C(CCC(=O)c1ccc2[nH]ncc2c1)c1ccco1
Show InChI InChI=1S/C15H12N2O3/c18-13(5-6-14(19)15-2-1-7-20-15)10-3-4-12-11(8-10)9-16-17-12/h1-4,7-9H,5-6H2,(H,16,17)
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n/an/an/an/a 127n/an/an/an/a



Samumed, LLC

US Patent


Assay Description
Compounds that enhance the Wnt activity, or Activators, were assayed as follows. Reporter cell lines were generated by stably transducing cells of co...


US Patent US10457672 (2019)


BindingDB Entry DOI: 10.7270/Q26975ZV
More data for this
Ligand-Target Pair
Wnt/beta-Catenin


(Homo sapiens (Human))
BDBM418425
PNG
(US10457672, Compound 559)
Show SMILES FC(F)(F)c1ccccc1C(=O)CCC(=O)c1cccs1
Show InChI InChI=1S/C15H11F3O2S/c16-15(17,18)11-5-2-1-4-10(11)12(19)7-8-13(20)14-6-3-9-21-14/h1-6,9H,7-8H2
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Samumed, LLC

US Patent


Assay Description
Compounds that enhance the Wnt activity, or Activators, were assayed as follows. Reporter cell lines were generated by stably transducing cells of co...


US Patent US10457672 (2019)


BindingDB Entry DOI: 10.7270/Q26975ZV
More data for this
Ligand-Target Pair
Wnt/beta-Catenin


(Homo sapiens (Human))
BDBM418426
PNG
(US10457672, Compound 560)
Show SMILES Cc1ccccc1C(=O)CCC(=O)c1cccs1
Show InChI InChI=1S/C15H14O2S/c1-11-5-2-3-6-12(11)13(16)8-9-14(17)15-7-4-10-18-15/h2-7,10H,8-9H2,1H3
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Samumed, LLC

US Patent


Assay Description
Compounds that enhance the Wnt activity, or Activators, were assayed as follows. Reporter cell lines were generated by stably transducing cells of co...


US Patent US10457672 (2019)


BindingDB Entry DOI: 10.7270/Q26975ZV
More data for this
Ligand-Target Pair
Wnt/beta-Catenin


(Homo sapiens (Human))
BDBM418430
PNG
(US10457672, Compound 718)
Show SMILES O=C(CCC(=O)c1ncccn1)c1ccccc1
Show InChI InChI=1S/C14H12N2O2/c17-12(11-5-2-1-3-6-11)7-8-13(18)14-15-9-4-10-16-14/h1-6,9-10H,7-8H2
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Samumed, LLC

US Patent


Assay Description
Compounds that enhance the Wnt activity, or Activators, were assayed as follows. Reporter cell lines were generated by stably transducing cells of co...


US Patent US10457672 (2019)


BindingDB Entry DOI: 10.7270/Q26975ZV
More data for this
Ligand-Target Pair
Wnt/beta-Catenin


(Homo sapiens (Human))
BDBM417465
PNG
(US10457672, Compound 3)
Show SMILES Oc1cc(C(=O)CCC(=O)c2ccccc2)c(O)c2OCCOc12
Show InChI InChI=1S/C18H16O6/c19-13(11-4-2-1-3-5-11)6-7-14(20)12-10-15(21)17-18(16(12)22)24-9-8-23-17/h1-5,10,21-22H,6-9H2
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Samumed, LLC

US Patent


Assay Description
Compounds that enhance the Wnt activity, or Activators, were assayed as follows. Reporter cell lines were generated by stably transducing cells of co...


US Patent US10457672 (2019)


BindingDB Entry DOI: 10.7270/Q26975ZV
More data for this
Ligand-Target Pair
Wnt/beta-Catenin


(Homo sapiens (Human))
BDBM417775
PNG
(US10457672, Compound 14)
Show SMILES O=C(CCC(=O)c1ccc2OCCOc2c1)c1cccnc1
Show InChI InChI=1S/C17H15NO4/c19-14(4-5-15(20)13-2-1-7-18-11-13)12-3-6-16-17(10-12)22-9-8-21-16/h1-3,6-7,10-11H,4-5,8-9H2
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Samumed, LLC

US Patent


Assay Description
Compounds that enhance the Wnt activity, or Activators, were assayed as follows. Reporter cell lines were generated by stably transducing cells of co...


US Patent US10457672 (2019)


BindingDB Entry DOI: 10.7270/Q26975ZV
More data for this
Ligand-Target Pair
Wnt/beta-Catenin


(Homo sapiens (Human))
BDBM417830
PNG
(US10457672, Compound 16)
Show SMILES FC(F)(F)c1ccccc1C(=O)CCC(=O)c1ccc2OCCSc2c1
Show InChI InChI=1S/C19H15F3O3S/c20-19(21,22)14-4-2-1-3-13(14)16(24)7-6-15(23)12-5-8-17-18(11-12)26-10-9-25-17/h1-5,8,11H,6-7,9-10H2
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Samumed, LLC

US Patent


Assay Description
Compounds that enhance the Wnt activity, or Activators, were assayed as follows. Reporter cell lines were generated by stably transducing cells of co...


US Patent US10457672 (2019)


BindingDB Entry DOI: 10.7270/Q26975ZV
More data for this
Ligand-Target Pair
Wnt/beta-Catenin


(Homo sapiens (Human))
BDBM418329
PNG
(US10457672, Compound 209)
Show SMILES COc1ccc(cc1OC)C(=O)CCC(=O)c1ccncc1
Show InChI InChI=1S/C17H17NO4/c1-21-16-6-3-13(11-17(16)22-2)15(20)5-4-14(19)12-7-9-18-10-8-12/h3,6-11H,4-5H2,1-2H3
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Samumed, LLC

US Patent


Assay Description
Compounds that enhance the Wnt activity, or Activators, were assayed as follows. Reporter cell lines were generated by stably transducing cells of co...


US Patent US10457672 (2019)


BindingDB Entry DOI: 10.7270/Q26975ZV
More data for this
Ligand-Target Pair
Wnt/beta-Catenin


(Homo sapiens (Human))
BDBM418350
PNG
(US10457672, Compound 274)
Show SMILES O=C(CCC(=O)c1ccc2[nH]cnc2c1)c1ccccc1
Show InChI InChI=1S/C17H14N2O2/c20-16(12-4-2-1-3-5-12)8-9-17(21)13-6-7-14-15(10-13)19-11-18-14/h1-7,10-11H,8-9H2,(H,18,19)
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n/an/an/an/a 6.80E+3n/an/an/an/a



Samumed, LLC

US Patent


Assay Description
Compounds that enhance the Wnt activity, or Activators, were assayed as follows. Reporter cell lines were generated by stably transducing cells of co...


US Patent US10457672 (2019)


BindingDB Entry DOI: 10.7270/Q26975ZV
More data for this
Ligand-Target Pair
Wnt/beta-Catenin


(Homo sapiens (Human))
BDBM418355
PNG
(US10457672, Compound 288)
Show SMILES FC(F)(F)c1ccccc1C(=O)CCC(=O)c1ccc2ocnc2c1
Show InChI InChI=1S/C18H12F3NO3/c19-18(20,21)13-4-2-1-3-12(13)16(24)7-6-15(23)11-5-8-17-14(9-11)22-10-25-17/h1-5,8-10H,6-7H2
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Samumed, LLC

US Patent


Assay Description
Compounds that enhance the Wnt activity, or Activators, were assayed as follows. Reporter cell lines were generated by stably transducing cells of co...


US Patent US10457672 (2019)


BindingDB Entry DOI: 10.7270/Q26975ZV
More data for this
Ligand-Target Pair
Wnt/beta-Catenin


(Homo sapiens (Human))
BDBM418360
PNG
(US10457672, Compound 301)
Show SMILES FC(F)(F)c1ccccc1C(=O)CCC(=O)c1ccc2sccc2c1
Show InChI InChI=1S/C19H13F3O2S/c20-19(21,22)15-4-2-1-3-14(15)17(24)7-6-16(23)12-5-8-18-13(11-12)9-10-25-18/h1-5,8-11H,6-7H2
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Samumed, LLC

US Patent


Assay Description
Compounds that enhance the Wnt activity, or Activators, were assayed as follows. Reporter cell lines were generated by stably transducing cells of co...


US Patent US10457672 (2019)


BindingDB Entry DOI: 10.7270/Q26975ZV
More data for this
Ligand-Target Pair
Wnt/beta-Catenin


(Homo sapiens (Human))
BDBM418362
PNG
(US10457672, Compound 310)
Show SMILES O=C(CCC(=O)c1ccccn1)c1ccc2sccc2c1
Show InChI InChI=1S/C17H13NO2S/c19-15(5-6-16(20)14-3-1-2-9-18-14)12-4-7-17-13(11-12)8-10-21-17/h1-4,7-11H,5-6H2
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n/an/an/an/a 68n/an/an/an/a



Samumed, LLC

US Patent


Assay Description
Compounds that enhance the Wnt activity, or Activators, were assayed as follows. Reporter cell lines were generated by stably transducing cells of co...


US Patent US10457672 (2019)


BindingDB Entry DOI: 10.7270/Q26975ZV
More data for this
Ligand-Target Pair
Wnt/beta-Catenin


(Homo sapiens (Human))
BDBM418367
PNG
(US10457672, Compound 319)
Show SMILES COc1ccccc1C(=O)CCC(=O)c1c[nH]c2ccccc12
Show InChI InChI=1S/C19H17NO3/c1-23-19-9-5-3-7-14(19)17(21)10-11-18(22)15-12-20-16-8-4-2-6-13(15)16/h2-9,12,20H,10-11H2,1H3
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Samumed, LLC

US Patent


Assay Description
Compounds that enhance the Wnt activity, or Activators, were assayed as follows. Reporter cell lines were generated by stably transducing cells of co...


US Patent US10457672 (2019)


BindingDB Entry DOI: 10.7270/Q26975ZV
More data for this
Ligand-Target Pair
Wnt/beta-Catenin


(Homo sapiens (Human))
BDBM418369
PNG
(US10457672, Compound 325)
Show SMILES O=C(CCC(=O)c1ccccc1)c1c[nH]c2ccccc12
Show InChI InChI=1S/C18H15NO2/c20-17(13-6-2-1-3-7-13)10-11-18(21)15-12-19-16-9-5-4-8-14(15)16/h1-9,12,19H,10-11H2
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Samumed, LLC

US Patent


Assay Description
Compounds that enhance the Wnt activity, or Activators, were assayed as follows. Reporter cell lines were generated by stably transducing cells of co...


US Patent US10457672 (2019)


BindingDB Entry DOI: 10.7270/Q26975ZV
More data for this
Ligand-Target Pair
Wnt/beta-Catenin


(Homo sapiens (Human))
BDBM418373
PNG
(US10457672, Compound 334)
Show SMILES COc1ccc(cc1)C(=O)CCC(=O)c1n[nH]c2ccccc12
Show InChI InChI=1S/C18H16N2O3/c1-23-13-8-6-12(7-9-13)16(21)10-11-17(22)18-14-4-2-3-5-15(14)19-20-18/h2-9H,10-11H2,1H3,(H,19,20)
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Samumed, LLC

US Patent


Assay Description
Compounds that enhance the Wnt activity, or Activators, were assayed as follows. Reporter cell lines were generated by stably transducing cells of co...


US Patent US10457672 (2019)


BindingDB Entry DOI: 10.7270/Q26975ZV
More data for this
Ligand-Target Pair
Wnt/beta-Catenin


(Homo sapiens (Human))
BDBM418396
PNG
(US10457672, Compound 431)
Show SMILES COc1ccc(cc1OC)C(=O)CCC(=O)c1ncccn1
Show InChI InChI=1S/C16H16N2O4/c1-21-14-7-4-11(10-15(14)22-2)12(19)5-6-13(20)16-17-8-3-9-18-16/h3-4,7-10H,5-6H2,1-2H3
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Samumed, LLC

US Patent


Assay Description
Compounds that enhance the Wnt activity, or Activators, were assayed as follows. Reporter cell lines were generated by stably transducing cells of co...


US Patent US10457672 (2019)


BindingDB Entry DOI: 10.7270/Q26975ZV
More data for this
Ligand-Target Pair
Wnt/beta-Catenin


(Homo sapiens (Human))
BDBM418410
PNG
(US10457672, Compound 498)
Show SMILES FC(F)(F)c1ccccc1C(=O)CCC(=O)c1ccc2[nH]ncc2c1
Show InChI InChI=1S/C18H13F3N2O2/c19-18(20,21)14-4-2-1-3-13(14)17(25)8-7-16(24)11-5-6-15-12(9-11)10-22-23-15/h1-6,9-10H,7-8H2,(H,22,23)
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Samumed, LLC

US Patent


Assay Description
Compounds that enhance the Wnt activity, or Activators, were assayed as follows. Reporter cell lines were generated by stably transducing cells of co...


US Patent US10457672 (2019)


BindingDB Entry DOI: 10.7270/Q26975ZV
More data for this
Ligand-Target Pair
Wnt/beta-Catenin


(Homo sapiens (Human))
BDBM418427
PNG
(US10457672, Compound 562)
Show SMILES COc1ccccc1C(=O)CCC(=O)c1cccs1
Show InChI InChI=1S/C15H14O3S/c1-18-14-6-3-2-5-11(14)12(16)8-9-13(17)15-7-4-10-19-15/h2-7,10H,8-9H2,1H3
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Samumed, LLC

US Patent


Assay Description
Compounds that enhance the Wnt activity, or Activators, were assayed as follows. Reporter cell lines were generated by stably transducing cells of co...


US Patent US10457672 (2019)


BindingDB Entry DOI: 10.7270/Q26975ZV
More data for this
Ligand-Target Pair
Wnt/beta-Catenin


(Homo sapiens (Human))
BDBM418428
PNG
(US10457672, Compound 569)
Show SMILES Fc1cccnc1C(=O)CCC(=O)c1ccc2OCCOc2c1
Show InChI InChI=1S/C17H14FNO4/c18-12-2-1-7-19-17(12)14(21)5-4-13(20)11-3-6-15-16(10-11)23-9-8-22-15/h1-3,6-7,10H,4-5,8-9H2
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n/an/an/an/a 1.96n/an/an/an/a



Samumed, LLC

US Patent


Assay Description
Compounds that enhance the Wnt activity, or Activators, were assayed as follows. Reporter cell lines were generated by stably transducing cells of co...


US Patent US10457672 (2019)


BindingDB Entry DOI: 10.7270/Q26975ZV
More data for this
Ligand-Target Pair
Wnt/beta-Catenin


(Homo sapiens (Human))
BDBM418429
PNG
(US10457672, Compound 570)
Show SMILES FC(F)(F)c1cccnc1C(=O)CCC(=O)c1ccc2OCCOc2c1
Show InChI InChI=1S/C18H14F3NO4/c19-18(20,21)12-2-1-7-22-17(12)14(24)5-4-13(23)11-3-6-15-16(10-11)26-9-8-25-15/h1-3,6-7,10H,4-5,8-9H2
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Samumed, LLC

US Patent


Assay Description
Compounds that enhance the Wnt activity, or Activators, were assayed as follows. Reporter cell lines were generated by stably transducing cells of co...


US Patent US10457672 (2019)


BindingDB Entry DOI: 10.7270/Q26975ZV
More data for this
Ligand-Target Pair
Wnt/beta-Catenin


(Homo sapiens (Human))
BDBM418325
PNG
(US10457672, Compound 76)
Show SMILES COc1ccc(cc1)C(=O)CCC(=O)c1ccc2OCCCc2c1
Show InChI InChI=1S/C20H20O4/c1-23-17-7-4-14(5-8-17)18(21)9-10-19(22)15-6-11-20-16(13-15)3-2-12-24-20/h4-8,11,13H,2-3,9-10,12H2,1H3
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Samumed, LLC

US Patent


Assay Description
Compounds that enhance the Wnt activity, or Activators, were assayed as follows. Reporter cell lines were generated by stably transducing cells of co...


US Patent US10457672 (2019)


BindingDB Entry DOI: 10.7270/Q26975ZV
More data for this
Ligand-Target Pair
Wnt/beta-Catenin


(Homo sapiens (Human))
BDBM418338
PNG
(US10457672, Compound 238)
Show SMILES FC(F)(F)c1ccc(cc1)C(=O)CCC(=O)c1cccc2OCCOc12
Show InChI InChI=1S/C19H15F3O4/c20-19(21,22)13-6-4-12(5-7-13)15(23)8-9-16(24)14-2-1-3-17-18(14)26-11-10-25-17/h1-7H,8-11H2
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Samumed, LLC

US Patent


Assay Description
Compounds that enhance the Wnt activity, or Activators, were assayed as follows. Reporter cell lines were generated by stably transducing cells of co...


US Patent US10457672 (2019)


BindingDB Entry DOI: 10.7270/Q26975ZV
More data for this
Ligand-Target Pair
Wnt/beta-Catenin


(Homo sapiens (Human))
BDBM418345
PNG
(US10457672, Compound 258)
Show SMILES O=C(CCC(=O)c1ccccn1)c1ccc2[nH]ccc2c1
Show InChI InChI=1S/C17H14N2O2/c20-16(6-7-17(21)15-3-1-2-9-18-15)13-4-5-14-12(11-13)8-10-19-14/h1-5,8-11,19H,6-7H2
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Samumed, LLC

US Patent


Assay Description
Compounds that enhance the Wnt activity, or Activators, were assayed as follows. Reporter cell lines were generated by stably transducing cells of co...


US Patent US10457672 (2019)


BindingDB Entry DOI: 10.7270/Q26975ZV
More data for this
Ligand-Target Pair
Wnt/beta-Catenin


(Homo sapiens (Human))
BDBM418349
PNG
(US10457672, Compound 269)
Show SMILES COc1cccc(c1)C(=O)CCC(=O)c1ccc2[nH]cnc2c1
Show InChI InChI=1S/C18H16N2O3/c1-23-14-4-2-3-12(9-14)17(21)7-8-18(22)13-5-6-15-16(10-13)20-11-19-15/h2-6,9-11H,7-8H2,1H3,(H,19,20)
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Samumed, LLC

US Patent


Assay Description
Compounds that enhance the Wnt activity, or Activators, were assayed as follows. Reporter cell lines were generated by stably transducing cells of co...


US Patent US10457672 (2019)


BindingDB Entry DOI: 10.7270/Q26975ZV
More data for this
Ligand-Target Pair
Wnt/beta-Catenin


(Homo sapiens (Human))
BDBM418359
PNG
(US10457672, Compound 300)
Show SMILES O=C(CCC(=O)c1ccc2ocnc2c1)c1ccccc1
Show InChI InChI=1S/C17H13NO3/c19-15(12-4-2-1-3-5-12)7-8-16(20)13-6-9-17-14(10-13)18-11-21-17/h1-6,9-11H,7-8H2
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Samumed, LLC

US Patent


Assay Description
Compounds that enhance the Wnt activity, or Activators, were assayed as follows. Reporter cell lines were generated by stably transducing cells of co...


US Patent US10457672 (2019)


BindingDB Entry DOI: 10.7270/Q26975ZV
More data for this
Ligand-Target Pair
Wnt/beta-Catenin


(Homo sapiens (Human))
BDBM418368
PNG
(US10457672, Compound 320)
Show SMILES COc1cccc(c1)C(=O)CCC(=O)c1c[nH]c2ccccc12
Show InChI InChI=1S/C19H17NO3/c1-23-14-6-4-5-13(11-14)18(21)9-10-19(22)16-12-20-17-8-3-2-7-15(16)17/h2-8,11-12,20H,9-10H2,1H3
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Samumed, LLC

US Patent


Assay Description
Compounds that enhance the Wnt activity, or Activators, were assayed as follows. Reporter cell lines were generated by stably transducing cells of co...


US Patent US10457672 (2019)


BindingDB Entry DOI: 10.7270/Q26975ZV
More data for this
Ligand-Target Pair
Wnt/beta-Catenin


(Homo sapiens (Human))
BDBM418372
PNG
(US10457672, Compound 332)
Show SMILES COc1ccccc1C(=O)CCC(=O)c1n[nH]c2ccccc12
Show InChI InChI=1S/C18H16N2O3/c1-23-17-9-5-3-7-13(17)15(21)10-11-16(22)18-12-6-2-4-8-14(12)19-20-18/h2-9H,10-11H2,1H3,(H,19,20)
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Samumed, LLC

US Patent


Assay Description
Compounds that enhance the Wnt activity, or Activators, were assayed as follows. Reporter cell lines were generated by stably transducing cells of co...


US Patent US10457672 (2019)


BindingDB Entry DOI: 10.7270/Q26975ZV
More data for this
Ligand-Target Pair
Wnt/beta-Catenin


(Homo sapiens (Human))
BDBM418375
PNG
(US10457672, Compound 339)
Show SMILES O=C(CCC(=O)c1ncccn1)c1ccc2OCCOc2c1
Show InChI InChI=1S/C16H14N2O4/c19-12(3-4-13(20)16-17-6-1-7-18-16)11-2-5-14-15(10-11)22-9-8-21-14/h1-2,5-7,10H,3-4,8-9H2
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Samumed, LLC

US Patent


Assay Description
Compounds that enhance the Wnt activity, or Activators, were assayed as follows. Reporter cell lines were generated by stably transducing cells of co...


US Patent US10457672 (2019)


BindingDB Entry DOI: 10.7270/Q26975ZV
More data for this
Ligand-Target Pair
Wnt/beta-Catenin


(Homo sapiens (Human))
BDBM418378
PNG
(US10457672, Compound 342)
Show SMILES Cc1ccccc1C(=O)CCC(=O)c1ccc2OCCOc2c1
Show InChI InChI=1S/C19H18O4/c1-13-4-2-3-5-15(13)17(21)8-7-16(20)14-6-9-18-19(12-14)23-11-10-22-18/h2-6,9,12H,7-8,10-11H2,1H3
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Samumed, LLC

US Patent


Assay Description
Compounds that enhance the Wnt activity, or Activators, were assayed as follows. Reporter cell lines were generated by stably transducing cells of co...


US Patent US10457672 (2019)


BindingDB Entry DOI: 10.7270/Q26975ZV
More data for this
Ligand-Target Pair
Wnt/beta-Catenin


(Homo sapiens (Human))
BDBM418386
PNG
(US10457672, Compound 365)
Show SMILES O=C(CCC(=O)c1ccc2OCCCc2c1)c1ccco1
Show InChI InChI=1S/C17H16O4/c18-14(6-7-15(19)17-4-2-10-21-17)12-5-8-16-13(11-12)3-1-9-20-16/h2,4-5,8,10-11H,1,3,6-7,9H2
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Samumed, LLC

US Patent


Assay Description
Compounds that enhance the Wnt activity, or Activators, were assayed as follows. Reporter cell lines were generated by stably transducing cells of co...


US Patent US10457672 (2019)


BindingDB Entry DOI: 10.7270/Q26975ZV
More data for this
Ligand-Target Pair
Wnt/beta-Catenin


(Homo sapiens (Human))
BDBM418393
PNG
(US10457672, Compound 425)
Show SMILES COc1ccc(cc1OC)C(=O)CCC(=O)c1cccc(C)c1
Show InChI InChI=1S/C19H20O4/c1-13-5-4-6-14(11-13)16(20)8-9-17(21)15-7-10-18(22-2)19(12-15)23-3/h4-7,10-12H,8-9H2,1-3H3
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Samumed, LLC

US Patent


Assay Description
Compounds that enhance the Wnt activity, or Activators, were assayed as follows. Reporter cell lines were generated by stably transducing cells of co...


US Patent US10457672 (2019)


BindingDB Entry DOI: 10.7270/Q26975ZV
More data for this
Ligand-Target Pair
Wnt/beta-Catenin


(Homo sapiens (Human))
BDBM418403
PNG
(US10457672, Compound 455)
Show SMILES Cc1ccccc1C(=O)CCC(=O)c1ccc2occc2c1
Show InChI InChI=1S/C19H16O3/c1-13-4-2-3-5-16(13)18(21)8-7-17(20)14-6-9-19-15(12-14)10-11-22-19/h2-6,9-12H,7-8H2,1H3
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Samumed, LLC

US Patent


Assay Description
Compounds that enhance the Wnt activity, or Activators, were assayed as follows. Reporter cell lines were generated by stably transducing cells of co...


US Patent US10457672 (2019)


BindingDB Entry DOI: 10.7270/Q26975ZV
More data for this
Ligand-Target Pair
Wnt/beta-Catenin


(Homo sapiens (Human))
BDBM418405
PNG
(US10457672, Compound 457)
Show SMILES Cc1ccc(cc1)C(=O)CCC(=O)c1ccc2occc2c1
Show InChI InChI=1S/C19H16O3/c1-13-2-4-14(5-3-13)17(20)7-8-18(21)15-6-9-19-16(12-15)10-11-22-19/h2-6,9-12H,7-8H2,1H3
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n/an/an/an/a 2.89E+3n/an/an/an/a



Samumed, LLC

US Patent


Assay Description
Compounds that enhance the Wnt activity, or Activators, were assayed as follows. Reporter cell lines were generated by stably transducing cells of co...


US Patent US10457672 (2019)


BindingDB Entry DOI: 10.7270/Q26975ZV
More data for this
Ligand-Target Pair
Wnt/beta-Catenin


(Homo sapiens (Human))
BDBM418411
PNG
(US10457672, Compound 503)
Show SMILES Cc1ccc(cc1)C(=O)CCC(=O)c1ccc2[nH]ncc2c1
Show InChI InChI=1S/C18H16N2O2/c1-12-2-4-13(5-3-12)17(21)8-9-18(22)14-6-7-16-15(10-14)11-19-20-16/h2-7,10-11H,8-9H2,1H3,(H,19,20)
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Samumed, LLC

US Patent


Assay Description
Compounds that enhance the Wnt activity, or Activators, were assayed as follows. Reporter cell lines were generated by stably transducing cells of co...


US Patent US10457672 (2019)


BindingDB Entry DOI: 10.7270/Q26975ZV
More data for this
Ligand-Target Pair
Wnt/beta-Catenin


(Homo sapiens (Human))
BDBM418413
PNG
(US10457672, Compound 513)
Show SMILES O=C(CCC(=O)c1ccc2[nH]ncc2c1)c1ccccc1
Show InChI InChI=1S/C17H14N2O2/c20-16(12-4-2-1-3-5-12)8-9-17(21)13-6-7-15-14(10-13)11-18-19-15/h1-7,10-11H,8-9H2,(H,18,19)
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Samumed, LLC

US Patent


Assay Description
Compounds that enhance the Wnt activity, or Activators, were assayed as follows. Reporter cell lines were generated by stably transducing cells of co...


US Patent US10457672 (2019)


BindingDB Entry DOI: 10.7270/Q26975ZV
More data for this
Ligand-Target Pair
Wnt/beta-Catenin


(Homo sapiens (Human))
BDBM418431
PNG
(US10457672, Compound 737)
Show SMILES O=C(CCC(=O)c1ncccn1)c1ccc2CCCCc2c1
Show InChI InChI=1S/C18H18N2O2/c21-16(8-9-17(22)18-19-10-3-11-20-18)15-7-6-13-4-1-2-5-14(13)12-15/h3,6-7,10-12H,1-2,4-5,8-9H2
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Samumed, LLC

US Patent


Assay Description
Compounds that enhance the Wnt activity, or Activators, were assayed as follows. Reporter cell lines were generated by stably transducing cells of co...


US Patent US10457672 (2019)


BindingDB Entry DOI: 10.7270/Q26975ZV
More data for this
Ligand-Target Pair
Wnt/beta-Catenin


(Homo sapiens (Human))
BDBM417467
PNG
(US10457672, Compound 4)
Show SMILES Oc1c(O)c2OCCOc2cc1C(=O)CCC(=O)c1ccccc1
Show InChI InChI=1S/C18H16O6/c19-13(11-4-2-1-3-5-11)6-7-14(20)12-10-15-18(17(22)16(12)21)24-9-8-23-15/h1-5,10,21-22H,6-9H2
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Samumed, LLC

US Patent


Assay Description
Compounds that enhance the Wnt activity, or Activators, were assayed as follows. Reporter cell lines were generated by stably transducing cells of co...


US Patent US10457672 (2019)


BindingDB Entry DOI: 10.7270/Q26975ZV
More data for this
Ligand-Target Pair
Wnt/beta-Catenin


(Homo sapiens (Human))
BDBM417490
PNG
(US10457672, Compound 10)
Show SMILES FC(F)(F)c1ccc(cc1)C(=O)CCC(=O)c1ccc2OCCOc2c1
Show InChI InChI=1S/C19H15F3O4/c20-19(21,22)14-4-1-12(2-5-14)15(23)6-7-16(24)13-3-8-17-18(11-13)26-10-9-25-17/h1-5,8,11H,6-7,9-10H2
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Samumed, LLC

US Patent


Assay Description
Compounds that enhance the Wnt activity, or Activators, were assayed as follows. Reporter cell lines were generated by stably transducing cells of co...


US Patent US10457672 (2019)


BindingDB Entry DOI: 10.7270/Q26975ZV
More data for this
Ligand-Target Pair
Wnt/beta-Catenin


(Homo sapiens (Human))
BDBM417518
PNG
(US10457672, Compound 12)
Show SMILES COc1ccccc1C(=O)CCC(=O)c1ccc2OCCOc2c1
Show InChI InChI=1S/C19H18O5/c1-22-17-5-3-2-4-14(17)16(21)8-7-15(20)13-6-9-18-19(12-13)24-11-10-23-18/h2-6,9,12H,7-8,10-11H2,1H3
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Samumed, LLC

US Patent


Assay Description
Compounds that enhance the Wnt activity, or Activators, were assayed as follows. Reporter cell lines were generated by stably transducing cells of co...


US Patent US10457672 (2019)


BindingDB Entry DOI: 10.7270/Q26975ZV
More data for this
Ligand-Target Pair
Wnt/beta-Catenin


(Homo sapiens (Human))
BDBM417527
PNG
(US10457672, Compound 13)
Show SMILES COc1cccc(c1)C(=O)CCC(=O)c1ccc2OCCOc2c1
Show InChI InChI=1S/C19H18O5/c1-22-15-4-2-3-13(11-15)16(20)6-7-17(21)14-5-8-18-19(12-14)24-10-9-23-18/h2-5,8,11-12H,6-7,9-10H2,1H3
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Samumed, LLC

US Patent


Assay Description
Compounds that enhance the Wnt activity, or Activators, were assayed as follows. Reporter cell lines were generated by stably transducing cells of co...


US Patent US10457672 (2019)


BindingDB Entry DOI: 10.7270/Q26975ZV
More data for this
Ligand-Target Pair
Wnt/beta-Catenin


(Homo sapiens (Human))
BDBM417904
PNG
(US10457672, Compound 18)
Show SMILES FC(F)(F)c1ccc(cc1)C(=O)CCC(=O)c1ccc2OCCSc2c1
Show InChI InChI=1S/C19H15F3O3S/c20-19(21,22)14-4-1-12(2-5-14)15(23)6-7-16(24)13-3-8-17-18(11-13)26-10-9-25-17/h1-5,8,11H,6-7,9-10H2
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Samumed, LLC

US Patent


Assay Description
Compounds that enhance the Wnt activity, or Activators, were assayed as follows. Reporter cell lines were generated by stably transducing cells of co...


US Patent US10457672 (2019)


BindingDB Entry DOI: 10.7270/Q26975ZV
More data for this
Ligand-Target Pair
Wnt/beta-Catenin


(Homo sapiens (Human))
BDBM418005
PNG
(US10457672, Compound 21)
Show SMILES Fc1ccc(cc1)C(=O)CCC(=O)c1ccc2OCCSc2c1
Show InChI InChI=1S/C18H15FO3S/c19-14-4-1-12(2-5-14)15(20)6-7-16(21)13-3-8-17-18(11-13)23-10-9-22-17/h1-5,8,11H,6-7,9-10H2
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Samumed, LLC

US Patent


Assay Description
Compounds that enhance the Wnt activity, or Activators, were assayed as follows. Reporter cell lines were generated by stably transducing cells of co...


US Patent US10457672 (2019)


BindingDB Entry DOI: 10.7270/Q26975ZV
More data for this
Ligand-Target Pair
Wnt/beta-Catenin


(Homo sapiens (Human))
BDBM418322
PNG
(US10457672, Compound 68)
Show SMILES FC(F)(F)c1ccccc1C(=O)CCC(=O)c1ccc2OCCCc2c1
Show InChI InChI=1S/C20H17F3O3/c21-20(22,23)16-6-2-1-5-15(16)18(25)9-8-17(24)13-7-10-19-14(12-13)4-3-11-26-19/h1-2,5-7,10,12H,3-4,8-9,11H2
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Samumed, LLC

US Patent


Assay Description
Compounds that enhance the Wnt activity, or Activators, were assayed as follows. Reporter cell lines were generated by stably transducing cells of co...


US Patent US10457672 (2019)


BindingDB Entry DOI: 10.7270/Q26975ZV
More data for this
Ligand-Target Pair
Wnt/beta-Catenin


(Homo sapiens (Human))
BDBM418334
PNG
(US10457672, Compound 217)
Show SMILES COc1cccc(c1)C(=O)CCC(=O)c1ccc2OCOc2c1
Show InChI InChI=1S/C18H16O5/c1-21-14-4-2-3-12(9-14)15(19)6-7-16(20)13-5-8-17-18(10-13)23-11-22-17/h2-5,8-10H,6-7,11H2,1H3
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n/an/an/an/a 343n/an/an/an/a



Samumed, LLC

US Patent


Assay Description
Compounds that enhance the Wnt activity, or Activators, were assayed as follows. Reporter cell lines were generated by stably transducing cells of co...


US Patent US10457672 (2019)


BindingDB Entry DOI: 10.7270/Q26975ZV
More data for this
Ligand-Target Pair
Wnt/beta-Catenin


(Homo sapiens (Human))
BDBM418341
PNG
(US10457672, Compound 248)
Show SMILES O=C(CCC(=O)c1cccc2OCCOc12)c1ccccc1
Show InChI InChI=1S/C18H16O4/c19-15(13-5-2-1-3-6-13)9-10-16(20)14-7-4-8-17-18(14)22-12-11-21-17/h1-8H,9-12H2
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Samumed, LLC

US Patent


Assay Description
Compounds that enhance the Wnt activity, or Activators, were assayed as follows. Reporter cell lines were generated by stably transducing cells of co...


US Patent US10457672 (2019)


BindingDB Entry DOI: 10.7270/Q26975ZV
More data for this
Ligand-Target Pair
Wnt/beta-Catenin


(Homo sapiens (Human))
BDBM418351
PNG
(US10457672, Compound 275)
Show SMILES FC(F)(F)c1ccccc1C(=O)CCC(=O)c1ccc2occc2c1
Show InChI InChI=1S/C19H13F3O3/c20-19(21,22)15-4-2-1-3-14(15)17(24)7-6-16(23)12-5-8-18-13(11-12)9-10-25-18/h1-5,8-11H,6-7H2
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Samumed, LLC

US Patent


Assay Description
Compounds that enhance the Wnt activity, or Activators, were assayed as follows. Reporter cell lines were generated by stably transducing cells of co...


US Patent US10457672 (2019)


BindingDB Entry DOI: 10.7270/Q26975ZV
More data for this
Ligand-Target Pair
Wnt/beta-Catenin


(Homo sapiens (Human))
BDBM418361
PNG
(US10457672, Compound 307)
Show SMILES COc1ccccc1C(=O)CCC(=O)c1ccc2sccc2c1
Show InChI InChI=1S/C19H16O3S/c1-22-18-5-3-2-4-15(18)17(21)8-7-16(20)13-6-9-19-14(12-13)10-11-23-19/h2-6,9-12H,7-8H2,1H3
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n/an/an/an/a 55n/an/an/an/a



Samumed, LLC

US Patent


Assay Description
Compounds that enhance the Wnt activity, or Activators, were assayed as follows. Reporter cell lines were generated by stably transducing cells of co...


US Patent US10457672 (2019)


BindingDB Entry DOI: 10.7270/Q26975ZV
More data for this
Ligand-Target Pair
Wnt/beta-Catenin


(Homo sapiens (Human))
BDBM418363
PNG
(US10457672, Compound 313)
Show SMILES O=C(CCC(=O)c1ccc2sccc2c1)c1ccccc1
Show InChI InChI=1S/C18H14O2S/c19-16(13-4-2-1-3-5-13)7-8-17(20)14-6-9-18-15(12-14)10-11-21-18/h1-6,9-12H,7-8H2
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n/an/an/an/a 44n/an/an/an/a



Samumed, LLC

US Patent


Assay Description
Compounds that enhance the Wnt activity, or Activators, were assayed as follows. Reporter cell lines were generated by stably transducing cells of co...


US Patent US10457672 (2019)


BindingDB Entry DOI: 10.7270/Q26975ZV
More data for this
Ligand-Target Pair
Wnt/beta-Catenin


(Homo sapiens (Human))
BDBM418364
PNG
(US10457672, Compound 314)
Show SMILES FC(F)(F)c1ccccc1C(=O)CCC(=O)c1c[nH]c2ccccc12
Show InChI InChI=1S/C19H14F3NO2/c20-19(21,22)15-7-3-1-6-13(15)17(24)9-10-18(25)14-11-23-16-8-4-2-5-12(14)16/h1-8,11,23H,9-10H2
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Samumed, LLC

US Patent


Assay Description
Compounds that enhance the Wnt activity, or Activators, were assayed as follows. Reporter cell lines were generated by stably transducing cells of co...


US Patent US10457672 (2019)


BindingDB Entry DOI: 10.7270/Q26975ZV
More data for this
Ligand-Target Pair
Wnt/beta-Catenin


(Homo sapiens (Human))
BDBM418370
PNG
(US10457672, Compound 326)
Show SMILES FC(F)(F)c1ccccc1C(=O)CCC(=O)c1n[nH]c2ccccc12
Show InChI InChI=1S/C18H13F3N2O2/c19-18(20,21)13-7-3-1-5-11(13)15(24)9-10-16(25)17-12-6-2-4-8-14(12)22-23-17/h1-8H,9-10H2,(H,22,23)
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Samumed, LLC

US Patent


Assay Description
Compounds that enhance the Wnt activity, or Activators, were assayed as follows. Reporter cell lines were generated by stably transducing cells of co...


US Patent US10457672 (2019)


BindingDB Entry DOI: 10.7270/Q26975ZV
More data for this
Ligand-Target Pair
Wnt/beta-Catenin


(Homo sapiens (Human))
BDBM418374
PNG
(US10457672, Compound 338)
Show SMILES O=C(CCC(=O)c1ccccc1)c1n[nH]c2ccccc12
Show InChI InChI=1S/C17H14N2O2/c20-15(12-6-2-1-3-7-12)10-11-16(21)17-13-8-4-5-9-14(13)18-19-17/h1-9H,10-11H2,(H,18,19)
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Samumed, LLC

US Patent


Assay Description
Compounds that enhance the Wnt activity, or Activators, were assayed as follows. Reporter cell lines were generated by stably transducing cells of co...


US Patent US10457672 (2019)


BindingDB Entry DOI: 10.7270/Q26975ZV
More data for this
Ligand-Target Pair
Wnt/beta-Catenin


(Homo sapiens (Human))
BDBM418382
PNG
(US10457672, Compound 346)
Show SMILES O=C(CCC(=O)c1ccc2OCCOc2c1)c1ccco1
Show InChI InChI=1S/C16H14O5/c17-12(4-5-13(18)14-2-1-7-19-14)11-3-6-15-16(10-11)21-9-8-20-15/h1-3,6-7,10H,4-5,8-9H2
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Samumed, LLC

US Patent


Assay Description
Compounds that enhance the Wnt activity, or Activators, were assayed as follows. Reporter cell lines were generated by stably transducing cells of co...


US Patent US10457672 (2019)


BindingDB Entry DOI: 10.7270/Q26975ZV
More data for this
Ligand-Target Pair
Wnt/beta-Catenin


(Homo sapiens (Human))
BDBM418385
PNG
(US10457672, Compound 364)
Show SMILES O=C(CCC(=O)c1ccc2OCCCc2c1)c1cccs1
Show InChI InChI=1S/C17H16O3S/c18-14(6-7-15(19)17-4-2-10-21-17)12-5-8-16-13(11-12)3-1-9-20-16/h2,4-5,8,10-11H,1,3,6-7,9H2
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Samumed, LLC

US Patent


Assay Description
Compounds that enhance the Wnt activity, or Activators, were assayed as follows. Reporter cell lines were generated by stably transducing cells of co...


US Patent US10457672 (2019)


BindingDB Entry DOI: 10.7270/Q26975ZV
More data for this
Ligand-Target Pair
Wnt/beta-Catenin


(Homo sapiens (Human))
BDBM418389
PNG
(US10457672, Compound 374)
Show SMILES O=C(CCC(=O)c1ccc2OCOc2c1)c1cccs1
Show InChI InChI=1S/C15H12O4S/c16-11(4-5-12(17)15-2-1-7-20-15)10-3-6-13-14(8-10)19-9-18-13/h1-3,6-8H,4-5,9H2
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Samumed, LLC

US Patent


Assay Description
Compounds that enhance the Wnt activity, or Activators, were assayed as follows. Reporter cell lines were generated by stably transducing cells of co...


US Patent US10457672 (2019)


BindingDB Entry DOI: 10.7270/Q26975ZV
More data for this
Ligand-Target Pair
Wnt/beta-Catenin


(Homo sapiens (Human))
BDBM418399
PNG
(US10457672, Compound 442)
Show SMILES O=C(CCC(=O)c1cccc2OCCOc12)c1ccco1
Show InChI InChI=1S/C16H14O5/c17-12(6-7-13(18)14-5-2-8-19-14)11-3-1-4-15-16(11)21-10-9-20-15/h1-5,8H,6-7,9-10H2
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n/an/an/an/a 2.15E+3n/an/an/an/a



Samumed, LLC

US Patent


Assay Description
Compounds that enhance the Wnt activity, or Activators, were assayed as follows. Reporter cell lines were generated by stably transducing cells of co...


US Patent US10457672 (2019)


BindingDB Entry DOI: 10.7270/Q26975ZV
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%