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Patent code US10463663

Compile Data Set for Download or QSAR
Found 68 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
D-amino-acid oxidase


(Homo sapiens (Human))
BDBM210775
PNG
(US10463663, Example 4 | US9290456, 4 | US9931340, ...)
Show SMILES Oc1cc(SCc2ccc(Cl)cc2)n[nH]c1=O
Show InChI InChI=1S/C11H9ClN2O2S/c12-8-3-1-7(2-4-8)6-17-10-5-9(15)11(16)14-13-10/h1-5H,6H2,(H,13,15)(H,14,16)
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n/an/a 3.70n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
The functional activity of compounds inhibiting the DAAO enzyme was determined by utilizing the co-product of the catalysis of D-Serine, H2O2 which c...


US Patent US10463663 (2019)

More data for this
Ligand-Target Pair
D-amino-acid oxidase


(Homo sapiens (Human))
BDBM210789
PNG
(US10463663, Example 24 | US9290456, 24 | US9931340...)
Show SMILES Cc1cc(CCc2cc(O)c(=O)[nH]n2)ccc1F
Show InChI InChI=1S/C13H13FN2O2/c1-8-6-9(3-5-11(8)14)2-4-10-7-12(17)13(18)16-15-10/h3,5-7H,2,4H2,1H3,(H,15,17)(H,16,18)
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n/an/a 6n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
The functional activity of compounds inhibiting the DAAO enzyme was determined by utilizing the co-product of the catalysis of D-Serine, H2O2 which c...


US Patent US10463663 (2019)

More data for this
Ligand-Target Pair
D-amino-acid oxidase


(Homo sapiens (Human))
BDBM210785
PNG
(US10463663, Example 20 | US9290456, 20 | US9931340...)
Show SMILES Oc1cc(CCc2cccc(Cl)c2)n[nH]c1=O
Show InChI InChI=1S/C12H11ClN2O2/c13-9-3-1-2-8(6-9)4-5-10-7-11(16)12(17)15-14-10/h1-3,6-7H,4-5H2,(H,14,16)(H,15,17)
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Takeda Pharmaceutical Company Limited

US Patent


Assay Description
The functional activity of compounds inhibiting the DAAO enzyme was determined by utilizing the co-product of the catalysis of D-Serine, H2O2 which c...


US Patent US10463663 (2019)

More data for this
Ligand-Target Pair
D-amino-acid oxidase


(Homo sapiens (Human))
BDBM50431067
PNG
(CHEMBL2338797 | US10202399, Example 18 | US1046366...)
Show SMILES Oc1cc(CCc2cccc(F)c2)n[nH]c1=O
Show InChI InChI=1S/C12H11FN2O2/c13-9-3-1-2-8(6-9)4-5-10-7-11(16)12(17)15-14-10/h1-3,6-7H,4-5H2,(H,14,16)(H,15,17)
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n/an/a 9.70n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
The functional activity of compounds inhibiting the DAAO enzyme was determined by utilizing the co-product of the catalysis of D-Serine, H2O2 which c...


US Patent US10463663 (2019)

More data for this
Ligand-Target Pair
D-amino-acid oxidase


(Homo sapiens (Human))
BDBM210777
PNG
(US10463663, Example 9 | US9290456, 9 | US9931340, ...)
Show SMILES Oc1cc(CCc2ccc(F)c(F)c2)n[nH]c1=O
Show InChI InChI=1S/C12H10F2N2O2/c13-9-4-2-7(5-10(9)14)1-3-8-6-11(17)12(18)16-15-8/h2,4-6H,1,3H2,(H,15,17)(H,16,18)
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Takeda Pharmaceutical Company Limited

US Patent


Assay Description
The functional activity of compounds inhibiting the DAAO enzyme was determined by utilizing the co-product of the catalysis of D-Serine, H2O2 which c...


US Patent US10463663 (2019)

More data for this
Ligand-Target Pair
D-amino-acid oxidase


(Homo sapiens (Human))
BDBM50431086
PNG
(CHEMBL2338800 | US10202399, Example 212 | US104636...)
Show SMILES Oc1cc(CCc2ccc(F)cc2)n[nH]c1=O
Show InChI InChI=1S/C12H11FN2O2/c13-9-4-1-8(2-5-9)3-6-10-7-11(16)12(17)15-14-10/h1-2,4-5,7H,3,6H2,(H,14,16)(H,15,17)
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Takeda Pharmaceutical Company Limited

US Patent


Assay Description
The functional activity of compounds inhibiting the DAAO enzyme was determined by utilizing the co-product of the catalysis of D-Serine, H2O2 which c...


US Patent US10463663 (2019)

More data for this
Ligand-Target Pair
D-amino-acid oxidase


(Homo sapiens (Human))
BDBM50431078
PNG
(CHEMBL2338786 | US10463663, Example 1 | US9290456,...)
Show SMILES Oc1cc(CCc2ccccc2)n[nH]c1=O
Show InChI InChI=1S/C12H12N2O2/c15-11-8-10(13-14-12(11)16)7-6-9-4-2-1-3-5-9/h1-5,8H,6-7H2,(H,13,15)(H,14,16)
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n/an/a 10n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
The functional activity of compounds inhibiting the DAAO enzyme was determined by utilizing the co-product of the catalysis of D-Serine, H2O2 which c...


US Patent US10463663 (2019)

More data for this
Ligand-Target Pair
D-amino-acid oxidase


(Homo sapiens (Human))
BDBM210827
PNG
(US10463663, Example 67 | US9290456, 67 | US9931340...)
Show SMILES Oc1cc(CCc2cc(F)c(c(F)c2)C(F)(F)F)n[nH]c1=O
Show InChI InChI=1S/C13H9F5N2O2/c14-8-3-6(4-9(15)11(8)13(16,17)18)1-2-7-5-10(21)12(22)20-19-7/h3-5H,1-2H2,(H,19,21)(H,20,22)
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Takeda Pharmaceutical Company Limited

US Patent


Assay Description
The functional activity of compounds inhibiting the DAAO enzyme was determined by utilizing the co-product of the catalysis of D-Serine, H2O2 which c...


US Patent US10463663 (2019)

More data for this
Ligand-Target Pair
D-amino-acid oxidase


(Homo sapiens (Human))
BDBM50431083
PNG
(CHEMBL2338803 | US10202399, Example 24 | US1046366...)
Show SMILES Oc1cc(CCc2cc(F)cc(F)c2)n[nH]c1=O
Show InChI InChI=1S/C12H10F2N2O2/c13-8-3-7(4-9(14)5-8)1-2-10-6-11(17)12(18)16-15-10/h3-6H,1-2H2,(H,15,17)(H,16,18)
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n/an/a 11n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
The functional activity of compounds inhibiting the DAAO enzyme was determined by utilizing the co-product of the catalysis of D-Serine, H2O2 which c...


US Patent US10463663 (2019)

More data for this
Ligand-Target Pair
D-amino-acid oxidase


(Homo sapiens (Human))
BDBM210802
PNG
(US10463663, Example 40 | US9290456, 40 | US9931340...)
Show SMILES Oc1cc(Cc2ccc(Cl)cc2)n[nH]c1=O
Show InChI InChI=1S/C11H9ClN2O2/c12-8-3-1-7(2-4-8)5-9-6-10(15)11(16)14-13-9/h1-4,6H,5H2,(H,13,15)(H,14,16)
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Takeda Pharmaceutical Company Limited

US Patent


Assay Description
The functional activity of compounds inhibiting the DAAO enzyme was determined by utilizing the co-product of the catalysis of D-Serine, H2O2 which c...


US Patent US10463663 (2019)

More data for this
Ligand-Target Pair
D-amino-acid oxidase


(Homo sapiens (Human))
BDBM210826
PNG
(US10463663, Example 66 | US9290456, 66 | US9931340...)
Show SMILES Cc1cc(ccc1CCc1cc(O)c(=O)[nH]n1)C(F)(F)F
Show InChI InChI=1S/C14H13F3N2O2/c1-8-6-10(14(15,16)17)4-2-9(8)3-5-11-7-12(20)13(21)19-18-11/h2,4,6-7H,3,5H2,1H3,(H,18,20)(H,19,21)
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n/an/a 12n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
The functional activity of compounds inhibiting the DAAO enzyme was determined by utilizing the co-product of the catalysis of D-Serine, H2O2 which c...


US Patent US10463663 (2019)

More data for this
Ligand-Target Pair
D-amino-acid oxidase


(Homo sapiens (Human))
BDBM210784
PNG
(US10463663, Example 19 | US9290456, 19 | US9931340...)
Show SMILES Oc1cc(Cc2ccccc2)n[nH]c1=O
Show InChI InChI=1S/C11H10N2O2/c14-10-7-9(12-13-11(10)15)6-8-4-2-1-3-5-8/h1-5,7H,6H2,(H,12,14)(H,13,15)
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Takeda Pharmaceutical Company Limited

US Patent


Assay Description
The functional activity of compounds inhibiting the DAAO enzyme was determined by utilizing the co-product of the catalysis of D-Serine, H2O2 which c...


US Patent US10463663 (2019)

More data for this
Ligand-Target Pair
D-amino-acid oxidase


(Homo sapiens (Human))
BDBM210810
PNG
(US10463663, Example 48 | US9290456, 48 | US9931340...)
Show SMILES Cc1cccc(Cc2cc(O)c(=O)[nH]n2)c1
Show InChI InChI=1S/C12H12N2O2/c1-8-3-2-4-9(5-8)6-10-7-11(15)12(16)14-13-10/h2-5,7H,6H2,1H3,(H,13,15)(H,14,16)
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Takeda Pharmaceutical Company Limited

US Patent


Assay Description
The functional activity of compounds inhibiting the DAAO enzyme was determined by utilizing the co-product of the catalysis of D-Serine, H2O2 which c...


US Patent US10463663 (2019)

More data for this
Ligand-Target Pair
D-amino-acid oxidase


(Homo sapiens (Human))
BDBM196661
PNG
(US10202399, Example 21 | US10463663, Example 17 | ...)
Show SMILES Oc1cc(CCc2ccc(F)cc2F)n[nH]c1=O
Show InChI InChI=1S/C12H10F2N2O2/c13-8-3-1-7(10(14)5-8)2-4-9-6-11(17)12(18)16-15-9/h1,3,5-6H,2,4H2,(H,15,17)(H,16,18)
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n/an/a 13n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
The functional activity of compounds inhibiting the DAAO enzyme was determined by utilizing the co-product of the catalysis of D-Serine, H2O2 which c...


US Patent US10463663 (2019)

More data for this
Ligand-Target Pair
D-amino-acid oxidase


(Homo sapiens (Human))
BDBM210824
PNG
(US10463663, Example 64 | US9290456, 64 | US9931340...)
Show SMILES Cc1cc(CCc2cc(O)c(=O)[nH]n2)ccc1C(F)(F)F
Show InChI InChI=1S/C14H13F3N2O2/c1-8-6-9(3-5-11(8)14(15,16)17)2-4-10-7-12(20)13(21)19-18-10/h3,5-7H,2,4H2,1H3,(H,18,20)(H,19,21)
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Takeda Pharmaceutical Company Limited

US Patent


Assay Description
The functional activity of compounds inhibiting the DAAO enzyme was determined by utilizing the co-product of the catalysis of D-Serine, H2O2 which c...


US Patent US10463663 (2019)

More data for this
Ligand-Target Pair
D-amino-acid oxidase


(Homo sapiens (Human))
BDBM210825
PNG
(US10463663, Example 65 | US9290456, 65 | US9931340...)
Show SMILES Oc1cc(CCc2ccc(c(Cl)c2)C(F)(F)F)n[nH]c1=O
Show InChI InChI=1S/C13H10ClF3N2O2/c14-10-5-7(2-4-9(10)13(15,16)17)1-3-8-6-11(20)12(21)19-18-8/h2,4-6H,1,3H2,(H,18,20)(H,19,21)
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Takeda Pharmaceutical Company Limited

US Patent


Assay Description
The functional activity of compounds inhibiting the DAAO enzyme was determined by utilizing the co-product of the catalysis of D-Serine, H2O2 which c...


US Patent US10463663 (2019)

More data for this
Ligand-Target Pair
D-amino-acid oxidase


(Homo sapiens (Human))
BDBM210787
PNG
(US10463663, Example 22 | US9290456, 22 | US9931340...)
Show SMILES Oc1cc(CCc2ccc(cc2)C#N)n[nH]c1=O
Show InChI InChI=1S/C13H11N3O2/c14-8-10-3-1-9(2-4-10)5-6-11-7-12(17)13(18)16-15-11/h1-4,7H,5-6H2,(H,15,17)(H,16,18)
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Takeda Pharmaceutical Company Limited

US Patent


Assay Description
The functional activity of compounds inhibiting the DAAO enzyme was determined by utilizing the co-product of the catalysis of D-Serine, H2O2 which c...


US Patent US10463663 (2019)

More data for this
Ligand-Target Pair
D-amino-acid oxidase


(Homo sapiens (Human))
BDBM210801
PNG
(US10463663, Example 39 | US9290456, 39 | US9931340...)
Show SMILES Oc1cc(Cc2cccc(Cl)c2)n[nH]c1=O
Show InChI InChI=1S/C11H9ClN2O2/c12-8-3-1-2-7(4-8)5-9-6-10(15)11(16)14-13-9/h1-4,6H,5H2,(H,13,15)(H,14,16)
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Takeda Pharmaceutical Company Limited

US Patent


Assay Description
The functional activity of compounds inhibiting the DAAO enzyme was determined by utilizing the co-product of the catalysis of D-Serine, H2O2 which c...


US Patent US10463663 (2019)

More data for this
Ligand-Target Pair
D-amino-acid oxidase


(Homo sapiens (Human))
BDBM50431069
PNG
(CHEMBL2338795 | US10202399, Example 27 | US1046366...)
Show SMILES Oc1cc(CCc2ccccc2F)n[nH]c1=O
Show InChI InChI=1S/C12H11FN2O2/c13-10-4-2-1-3-8(10)5-6-9-7-11(16)12(17)15-14-9/h1-4,7H,5-6H2,(H,14,16)(H,15,17)
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n/an/a 13n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
The functional activity of compounds inhibiting the DAAO enzyme was determined by utilizing the co-product of the catalysis of D-Serine, H2O2 which c...


US Patent US10463663 (2019)

More data for this
Ligand-Target Pair
D-amino-acid oxidase


(Homo sapiens (Human))
BDBM50431074
PNG
(CHEMBL2338790 | US10463663, Example 27 | US9212147...)
Show SMILES Oc1cc(CCc2ccc(Cl)cc2)n[nH]c1=O
Show InChI InChI=1S/C12H11ClN2O2/c13-9-4-1-8(2-5-9)3-6-10-7-11(16)12(17)15-14-10/h1-2,4-5,7H,3,6H2,(H,14,16)(H,15,17)
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n/an/a 13n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
The functional activity of compounds inhibiting the DAAO enzyme was determined by utilizing the co-product of the catalysis of D-Serine, H2O2 which c...


US Patent US10463663 (2019)

More data for this
Ligand-Target Pair
D-amino-acid oxidase


(Homo sapiens (Human))
BDBM210788
PNG
(US10463663, Example 23 | US9290456, 23 | US9931340...)
Show SMILES Cc1ccc(CCc2cc(O)c(=O)[nH]n2)cc1F
Show InChI InChI=1S/C13H13FN2O2/c1-8-2-3-9(6-11(8)14)4-5-10-7-12(17)13(18)16-15-10/h2-3,6-7H,4-5H2,1H3,(H,15,17)(H,16,18)
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n/an/a 14n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
The functional activity of compounds inhibiting the DAAO enzyme was determined by utilizing the co-product of the catalysis of D-Serine, H2O2 which c...


US Patent US10463663 (2019)

More data for this
Ligand-Target Pair
D-amino-acid oxidase


(Homo sapiens (Human))
BDBM210816
PNG
(US10463663, Example 54 | US9290456, 54 | US9931340...)
Show SMILES Oc1cc(CCc2c(F)cccc2Cl)n[nH]c1=O
Show InChI InChI=1S/C12H10ClFN2O2/c13-9-2-1-3-10(14)8(9)5-4-7-6-11(17)12(18)16-15-7/h1-3,6H,4-5H2,(H,15,17)(H,16,18)
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n/an/a 14n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
The functional activity of compounds inhibiting the DAAO enzyme was determined by utilizing the co-product of the catalysis of D-Serine, H2O2 which c...


US Patent US10463663 (2019)

More data for this
Ligand-Target Pair
D-amino-acid oxidase


(Homo sapiens (Human))
BDBM210783
PNG
(US10463663, Example 18 | US9290456, 18 | US9931340...)
Show SMILES Oc1cc(CCc2cccc(c2)C(F)F)n[nH]c1=O
Show InChI InChI=1S/C13H12F2N2O2/c14-12(15)9-3-1-2-8(6-9)4-5-10-7-11(18)13(19)17-16-10/h1-3,6-7,12H,4-5H2,(H,16,18)(H,17,19)
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Takeda Pharmaceutical Company Limited

US Patent


Assay Description
The functional activity of compounds inhibiting the DAAO enzyme was determined by utilizing the co-product of the catalysis of D-Serine, H2O2 which c...


US Patent US10463663 (2019)

More data for this
Ligand-Target Pair
D-amino-acid oxidase


(Homo sapiens (Human))
BDBM210821
PNG
(US10463663, Example 60 | US9290456, 60 | US9931340...)
Show SMILES Oc1cc(CCc2ccc(cc2F)C(F)(F)F)n[nH]c1=O
Show InChI InChI=1S/C13H10F4N2O2/c14-10-5-8(13(15,16)17)3-1-7(10)2-4-9-6-11(20)12(21)19-18-9/h1,3,5-6H,2,4H2,(H,18,20)(H,19,21)
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Takeda Pharmaceutical Company Limited

US Patent


Assay Description
The functional activity of compounds inhibiting the DAAO enzyme was determined by utilizing the co-product of the catalysis of D-Serine, H2O2 which c...


US Patent US10463663 (2019)

More data for this
Ligand-Target Pair
D-amino-acid oxidase


(Homo sapiens (Human))
BDBM210808
PNG
(US10463663, Example 46 | US9290456, 46 | US9931340...)
Show SMILES Oc1cc(Cc2ccccc2F)n[nH]c1=O
Show InChI InChI=1S/C11H9FN2O2/c12-9-4-2-1-3-7(9)5-8-6-10(15)11(16)14-13-8/h1-4,6H,5H2,(H,13,15)(H,14,16)
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Takeda Pharmaceutical Company Limited

US Patent


Assay Description
The functional activity of compounds inhibiting the DAAO enzyme was determined by utilizing the co-product of the catalysis of D-Serine, H2O2 which c...


US Patent US10463663 (2019)

More data for this
Ligand-Target Pair
D-amino-acid oxidase


(Homo sapiens (Human))
BDBM210823
PNG
(US10463663, Example 63 | US9290456, 63 | US9931340...)
Show SMILES Oc1cc(CCc2ccc(c(c2)C(F)(F)F)C(F)(F)F)n[nH]c1=O
Show InChI InChI=1S/C14H10F6N2O2/c15-13(16,17)9-4-2-7(5-10(9)14(18,19)20)1-3-8-6-11(23)12(24)22-21-8/h2,4-6H,1,3H2,(H,21,23)(H,22,24)
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Takeda Pharmaceutical Company Limited

US Patent


Assay Description
The functional activity of compounds inhibiting the DAAO enzyme was determined by utilizing the co-product of the catalysis of D-Serine, H2O2 which c...


US Patent US10463663 (2019)

More data for this
Ligand-Target Pair
D-amino-acid oxidase


(Homo sapiens (Human))
BDBM210804
PNG
(US10463663, Example 42 | US9290456, 42 | US9931340...)
Show SMILES Oc1cc(Cc2ccc(F)cc2)n[nH]c1=O
Show InChI InChI=1S/C11H9FN2O2/c12-8-3-1-7(2-4-8)5-9-6-10(15)11(16)14-13-9/h1-4,6H,5H2,(H,13,15)(H,14,16)
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Takeda Pharmaceutical Company Limited

US Patent


Assay Description
The functional activity of compounds inhibiting the DAAO enzyme was determined by utilizing the co-product of the catalysis of D-Serine, H2O2 which c...


US Patent US10463663 (2019)

More data for this
Ligand-Target Pair
D-amino-acid oxidase


(Homo sapiens (Human))
BDBM210781
PNG
(US10463663, Example 15 | US9290456, 15 | US9931340...)
Show SMILES Oc1cc(CCC2CCCC2)n[nH]c1=O
Show InChI InChI=1S/C11H16N2O2/c14-10-7-9(12-13-11(10)15)6-5-8-3-1-2-4-8/h7-8H,1-6H2,(H,12,14)(H,13,15)
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Takeda Pharmaceutical Company Limited

US Patent


Assay Description
The functional activity of compounds inhibiting the DAAO enzyme was determined by utilizing the co-product of the catalysis of D-Serine, H2O2 which c...


US Patent US10463663 (2019)

More data for this
Ligand-Target Pair
D-amino-acid oxidase


(Homo sapiens (Human))
BDBM210795
PNG
(US10463663, Example 32 | US9290456, 32 | US9931340...)
Show SMILES Oc1cc(CCc2cccc(OC(F)F)c2)n[nH]c1=O
Show InChI InChI=1S/C13H12F2N2O3/c14-13(15)20-10-3-1-2-8(6-10)4-5-9-7-11(18)12(19)17-16-9/h1-3,6-7,13H,4-5H2,(H,16,18)(H,17,19)
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Takeda Pharmaceutical Company Limited

US Patent


Assay Description
The functional activity of compounds inhibiting the DAAO enzyme was determined by utilizing the co-product of the catalysis of D-Serine, H2O2 which c...


US Patent US10463663 (2019)

More data for this
Ligand-Target Pair
D-amino-acid oxidase


(Homo sapiens (Human))
BDBM50431066
PNG
(CHEMBL2338798 | US10202399, Example 17 | US1046366...)
Show SMILES Oc1cc(CCc2cccc(c2)C(F)(F)F)n[nH]c1=O
Show InChI InChI=1S/C13H11F3N2O2/c14-13(15,16)9-3-1-2-8(6-9)4-5-10-7-11(19)12(20)18-17-10/h1-3,6-7H,4-5H2,(H,17,19)(H,18,20)
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Takeda Pharmaceutical Company Limited

US Patent


Assay Description
The functional activity of compounds inhibiting the DAAO enzyme was determined by utilizing the co-product of the catalysis of D-Serine, H2O2 which c...


US Patent US10463663 (2019)

More data for this
Ligand-Target Pair
D-amino-acid oxidase


(Homo sapiens (Human))
BDBM210793
PNG
(US10463663, Example 30 | US9290456, 30 | US9931340...)
Show SMILES Oc1cc(CCc2ccc(OC(F)F)cc2)n[nH]c1=O
Show InChI InChI=1S/C13H12F2N2O3/c14-13(15)20-10-5-2-8(3-6-10)1-4-9-7-11(18)12(19)17-16-9/h2-3,5-7,13H,1,4H2,(H,16,18)(H,17,19)
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Takeda Pharmaceutical Company Limited

US Patent


Assay Description
The functional activity of compounds inhibiting the DAAO enzyme was determined by utilizing the co-product of the catalysis of D-Serine, H2O2 which c...


US Patent US10463663 (2019)

More data for this
Ligand-Target Pair
D-amino-acid oxidase


(Homo sapiens (Human))
BDBM210807
PNG
(US10463663, Example 45 | US9290456, 45 | US9931340...)
Show SMILES Oc1cc(Cc2cccc(F)c2)n[nH]c1=O
Show InChI InChI=1S/C11H9FN2O2/c12-8-3-1-2-7(4-8)5-9-6-10(15)11(16)14-13-9/h1-4,6H,5H2,(H,13,15)(H,14,16)
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Takeda Pharmaceutical Company Limited

US Patent


Assay Description
The functional activity of compounds inhibiting the DAAO enzyme was determined by utilizing the co-product of the catalysis of D-Serine, H2O2 which c...


US Patent US10463663 (2019)

More data for this
Ligand-Target Pair
D-amino-acid oxidase


(Homo sapiens (Human))
BDBM210815
PNG
(US10463663, Example 53 | US9290456, 53 | US9931340...)
Show SMILES Oc1cc(CCc2c(F)cccc2F)n[nH]c1=O
Show InChI InChI=1S/C12H10F2N2O2/c13-9-2-1-3-10(14)8(9)5-4-7-6-11(17)12(18)16-15-7/h1-3,6H,4-5H2,(H,15,17)(H,16,18)
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Takeda Pharmaceutical Company Limited

US Patent


Assay Description
The functional activity of compounds inhibiting the DAAO enzyme was determined by utilizing the co-product of the catalysis of D-Serine, H2O2 which c...


US Patent US10463663 (2019)

More data for this
Ligand-Target Pair
D-amino-acid oxidase


(Homo sapiens (Human))
BDBM50431085
PNG
(CHEMBL2338801 | US10202399, Example 12 | US1046366...)
Show SMILES Oc1cc(CCc2ccc(cc2)C(F)(F)F)n[nH]c1=O
Show InChI InChI=1S/C13H11F3N2O2/c14-13(15,16)9-4-1-8(2-5-9)3-6-10-7-11(19)12(20)18-17-10/h1-2,4-5,7H,3,6H2,(H,17,19)(H,18,20)
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Takeda Pharmaceutical Company Limited

US Patent


Assay Description
The functional activity of compounds inhibiting the DAAO enzyme was determined by utilizing the co-product of the catalysis of D-Serine, H2O2 which c...


US Patent US10463663 (2019)

More data for this
Ligand-Target Pair
D-amino-acid oxidase


(Homo sapiens (Human))
BDBM210828
PNG
(US10463663, Example 68 | US9290456, 68 | US9931340...)
Show SMILES Oc1cc(CCc2ccc(c(F)c2)C(F)(F)F)n[nH]c1=O
Show InChI InChI=1S/C13H10F4N2O2/c14-10-5-7(2-4-9(10)13(15,16)17)1-3-8-6-11(20)12(21)19-18-8/h2,4-6H,1,3H2,(H,18,20)(H,19,21)
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Takeda Pharmaceutical Company Limited

US Patent


Assay Description
The functional activity of compounds inhibiting the DAAO enzyme was determined by utilizing the co-product of the catalysis of D-Serine, H2O2 which c...


US Patent US10463663 (2019)

More data for this
Ligand-Target Pair
D-amino-acid oxidase


(Homo sapiens (Human))
BDBM210820
PNG
(US10463663, Example 59 | US9290456, 59 | US9931340...)
Show SMILES Oc1cc(CCc2ccc(cc2Cl)C(F)(F)F)n[nH]c1=O
Show InChI InChI=1S/C13H10ClF3N2O2/c14-10-5-8(13(15,16)17)3-1-7(10)2-4-9-6-11(20)12(21)19-18-9/h1,3,5-6H,2,4H2,(H,18,20)(H,19,21)
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Takeda Pharmaceutical Company Limited

US Patent


Assay Description
The functional activity of compounds inhibiting the DAAO enzyme was determined by utilizing the co-product of the catalysis of D-Serine, H2O2 which c...


US Patent US10463663 (2019)

More data for this
Ligand-Target Pair
D-amino-acid oxidase


(Homo sapiens (Human))
BDBM210794
PNG
(US10202399, Example 28 | US10463663, Example 31 | ...)
Show SMILES Oc1cc(CCc2ccc(OC(F)(F)F)cc2)n[nH]c1=O
Show InChI InChI=1S/C13H11F3N2O3/c14-13(15,16)21-10-5-2-8(3-6-10)1-4-9-7-11(19)12(20)18-17-9/h2-3,5-7H,1,4H2,(H,17,19)(H,18,20)
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Takeda Pharmaceutical Company Limited

US Patent


Assay Description
The functional activity of compounds inhibiting the DAAO enzyme was determined by utilizing the co-product of the catalysis of D-Serine, H2O2 which c...


US Patent US10463663 (2019)

More data for this
Ligand-Target Pair
D-amino-acid oxidase


(Homo sapiens (Human))
BDBM210792
PNG
(US10463663, Example 28 | US9290456, 28 | US9931340...)
Show SMILES Oc1cc(CCc2ccccc2Cl)n[nH]c1=O
Show InChI InChI=1S/C12H11ClN2O2/c13-10-4-2-1-3-8(10)5-6-9-7-11(16)12(17)15-14-9/h1-4,7H,5-6H2,(H,14,16)(H,15,17)
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Takeda Pharmaceutical Company Limited

US Patent


Assay Description
The functional activity of compounds inhibiting the DAAO enzyme was determined by utilizing the co-product of the catalysis of D-Serine, H2O2 which c...


US Patent US10463663 (2019)

More data for this
Ligand-Target Pair
D-amino-acid oxidase


(Homo sapiens (Human))
BDBM210800
PNG
(US10463663, Example 38 | US9290456, 38 | US9931340...)
Show SMILES CN(CC1CCCCC1)c1cc(O)c(=O)[nH]n1
Show InChI InChI=1S/C12H19N3O2/c1-15(8-9-5-3-2-4-6-9)11-7-10(16)12(17)14-13-11/h7,9H,2-6,8H2,1H3,(H,13,16)(H,14,17)
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Takeda Pharmaceutical Company Limited

US Patent


Assay Description
The functional activity of compounds inhibiting the DAAO enzyme was determined by utilizing the co-product of the catalysis of D-Serine, H2O2 which c...


US Patent US10463663 (2019)

More data for this
Ligand-Target Pair
D-amino-acid oxidase


(Homo sapiens (Human))
BDBM210786
PNG
(US10463663, Example 21 | US9290456, 21 | US9931340...)
Show SMILES Oc1cc(n[nH]c1=O)C1(CC1)c1ccccc1
Show InChI InChI=1S/C13H12N2O2/c16-10-8-11(14-15-12(10)17)13(6-7-13)9-4-2-1-3-5-9/h1-5,8H,6-7H2,(H,14,16)(H,15,17)
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Takeda Pharmaceutical Company Limited

US Patent


Assay Description
The functional activity of compounds inhibiting the DAAO enzyme was determined by utilizing the co-product of the catalysis of D-Serine, H2O2 which c...


US Patent US10463663 (2019)

More data for this
Ligand-Target Pair
D-amino-acid oxidase


(Homo sapiens (Human))
BDBM419558
PNG
(US10463663, Example 3)
Show SMILES Oc1cc(CCc2ccc(F)cn2)n[nH]c1=O
Show InChI InChI=1S/C11H10FN3O2/c12-7-1-2-8(13-6-7)3-4-9-5-10(16)11(17)15-14-9/h1-2,5-6H,3-4H2,(H,14,16)(H,15,17)
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Takeda Pharmaceutical Company Limited

US Patent


Assay Description
The functional activity of compounds inhibiting the DAAO enzyme was determined by utilizing the co-product of the catalysis of D-Serine, H2O2 which c...


US Patent US10463663 (2019)

More data for this
Ligand-Target Pair
D-amino-acid oxidase


(Homo sapiens (Human))
BDBM210778
PNG
(US10463663, Example 10 | US9290456, 10 | US9290456...)
Show SMILES Oc1cc(CCc2cccc(OC(F)(F)F)c2)n[nH]c1=O
Show InChI InChI=1S/C13H11F3N2O3/c14-13(15,16)21-10-3-1-2-8(6-10)4-5-9-7-11(19)12(20)18-17-9/h1-3,6-7H,4-5H2,(H,17,19)(H,18,20)
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Takeda Pharmaceutical Company Limited

US Patent


Assay Description
The functional activity of compounds inhibiting the DAAO enzyme was determined by utilizing the co-product of the catalysis of D-Serine, H2O2 which c...


US Patent US10463663 (2019)

More data for this
Ligand-Target Pair
D-amino-acid oxidase


(Homo sapiens (Human))
BDBM210806
PNG
(US10463663, Example 44 | US9290456, 44 | US9931340...)
Show SMILES Oc1cc(Cc2ccccc2Cl)n[nH]c1=O
Show InChI InChI=1S/C11H9ClN2O2/c12-9-4-2-1-3-7(9)5-8-6-10(15)11(16)14-13-8/h1-4,6H,5H2,(H,13,15)(H,14,16)
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Takeda Pharmaceutical Company Limited

US Patent


Assay Description
The functional activity of compounds inhibiting the DAAO enzyme was determined by utilizing the co-product of the catalysis of D-Serine, H2O2 which c...


US Patent US10463663 (2019)

More data for this
Ligand-Target Pair
D-amino-acid oxidase


(Homo sapiens (Human))
BDBM210778
PNG
(US10463663, Example 10 | US9290456, 10 | US9290456...)
Show SMILES Oc1cc(CCc2cccc(OC(F)(F)F)c2)n[nH]c1=O
Show InChI InChI=1S/C13H11F3N2O3/c14-13(15,16)21-10-3-1-2-8(6-10)4-5-9-7-11(19)12(20)18-17-9/h1-3,6-7H,4-5H2,(H,17,19)(H,18,20)
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Takeda Pharmaceutical Company Limited

US Patent


Assay Description
The functional activity of compounds inhibiting the DAAO enzyme was determined by utilizing the co-product of the catalysis of D-Serine, H2O2 which c...


US Patent US10463663 (2019)

More data for this
Ligand-Target Pair
D-amino-acid oxidase


(Homo sapiens (Human))
BDBM210779
PNG
(US10463663, Example 50 | US9290456, 12 | US9290456...)
Show SMILES Oc1cc(CCc2cncc(c2)C(F)(F)F)n[nH]c1=O
Show InChI InChI=1S/C12H10F3N3O2/c13-12(14,15)8-3-7(5-16-6-8)1-2-9-4-10(19)11(20)18-17-9/h3-6H,1-2H2,(H,17,19)(H,18,20)
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Takeda Pharmaceutical Company Limited

US Patent


Assay Description
The functional activity of compounds inhibiting the DAAO enzyme was determined by utilizing the co-product of the catalysis of D-Serine, H2O2 which c...


US Patent US10463663 (2019)

More data for this
Ligand-Target Pair
D-amino-acid oxidase


(Homo sapiens (Human))
BDBM210811
PNG
(US10463663, Example 49 | US9290456, 49 | US9931340...)
Show SMILES Oc1cc(Cc2cccc(c2)C(F)(F)F)n[nH]c1=O
Show InChI InChI=1S/C12H9F3N2O2/c13-12(14,15)8-3-1-2-7(4-8)5-9-6-10(18)11(19)17-16-9/h1-4,6H,5H2,(H,16,18)(H,17,19)
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n/an/a 23n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
The functional activity of compounds inhibiting the DAAO enzyme was determined by utilizing the co-product of the catalysis of D-Serine, H2O2 which c...


US Patent US10463663 (2019)

More data for this
Ligand-Target Pair
D-amino-acid oxidase


(Homo sapiens (Human))
BDBM210796
PNG
(US10463663, Example 33 | US9290456, 33 | US9931340...)
Show SMILES Oc1cc(n[nH]c1=O)C1(CC1)c1ccc(F)cc1
Show InChI InChI=1S/C13H11FN2O2/c14-9-3-1-8(2-4-9)13(5-6-13)11-7-10(17)12(18)16-15-11/h1-4,7H,5-6H2,(H,15,17)(H,16,18)
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n/an/a 23n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
The functional activity of compounds inhibiting the DAAO enzyme was determined by utilizing the co-product of the catalysis of D-Serine, H2O2 which c...


US Patent US10463663 (2019)

More data for this
Ligand-Target Pair
D-amino-acid oxidase


(Homo sapiens (Human))
BDBM210779
PNG
(US10463663, Example 50 | US9290456, 12 | US9290456...)
Show SMILES Oc1cc(CCc2cncc(c2)C(F)(F)F)n[nH]c1=O
Show InChI InChI=1S/C12H10F3N3O2/c13-12(14,15)8-3-7(5-16-6-8)1-2-9-4-10(19)11(20)18-17-9/h3-6H,1-2H2,(H,17,19)(H,18,20)
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Takeda Pharmaceutical Company Limited

US Patent


Assay Description
The functional activity of compounds inhibiting the DAAO enzyme was determined by utilizing the co-product of the catalysis of D-Serine, H2O2 which c...


US Patent US10463663 (2019)

More data for this
Ligand-Target Pair
D-amino-acid oxidase


(Homo sapiens (Human))
BDBM210809
PNG
(US10463663, Example 47 | US9290456, 47 | US9931340...)
Show SMILES Cc1ccc(Cc2cc(O)c(=O)[nH]n2)cc1
Show InChI InChI=1S/C12H12N2O2/c1-8-2-4-9(5-3-8)6-10-7-11(15)12(16)14-13-10/h2-5,7H,6H2,1H3,(H,13,15)(H,14,16)
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Takeda Pharmaceutical Company Limited

US Patent


Assay Description
The functional activity of compounds inhibiting the DAAO enzyme was determined by utilizing the co-product of the catalysis of D-Serine, H2O2 which c...


US Patent US10463663 (2019)

More data for this
Ligand-Target Pair
D-amino-acid oxidase


(Homo sapiens (Human))
BDBM210797
PNG
(US10463663, Example 34 | US9290456, 34 | US9931340...)
Show SMILES CC(c1ccc(F)cc1)c1cc(O)c(=O)[nH]n1
Show InChI InChI=1/C12H11FN2O2/c1-7(8-2-4-9(13)5-3-8)10-6-11(16)12(17)15-14-10/h2-7H,1H3,(H,14,16)(H,15,17)
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Takeda Pharmaceutical Company Limited

US Patent


Assay Description
The functional activity of compounds inhibiting the DAAO enzyme was determined by utilizing the co-product of the catalysis of D-Serine, H2O2 which c...


US Patent US10463663 (2019)

More data for this
Ligand-Target Pair
D-amino-acid oxidase


(Homo sapiens (Human))
BDBM210805
PNG
(US10463663, Example 43 | US9290456, 43 | US9931340...)
Show SMILES Oc1cc(Cc2c(F)cccc2Cl)n[nH]c1=O
Show InChI InChI=1S/C11H8ClFN2O2/c12-8-2-1-3-9(13)7(8)4-6-5-10(16)11(17)15-14-6/h1-3,5H,4H2,(H,14,16)(H,15,17)
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Takeda Pharmaceutical Company Limited

US Patent


Assay Description
The functional activity of compounds inhibiting the DAAO enzyme was determined by utilizing the co-product of the catalysis of D-Serine, H2O2 which c...


US Patent US10463663 (2019)

More data for this
Ligand-Target Pair
D-amino-acid oxidase


(Homo sapiens (Human))
BDBM210822
PNG
(US10463663, Example 62 | US9290456, 62 | US9931340...)
Show SMILES Oc1cc(CCc2ccc(cc2C(F)(F)F)C(F)(F)F)n[nH]c1=O
Show InChI InChI=1S/C14H10F6N2O2/c15-13(16,17)8-3-1-7(10(5-8)14(18,19)20)2-4-9-6-11(23)12(24)22-21-9/h1,3,5-6H,2,4H2,(H,21,23)(H,22,24)
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Takeda Pharmaceutical Company Limited

US Patent


Assay Description
The functional activity of compounds inhibiting the DAAO enzyme was determined by utilizing the co-product of the catalysis of D-Serine, H2O2 which c...


US Patent US10463663 (2019)

More data for this
Ligand-Target Pair
D-amino-acid oxidase


(Homo sapiens (Human))
BDBM210776
PNG
(US10463663, Example 5 | US9290456, 5 | US9931340, ...)
Show SMILES Oc1cc(CCc2ccc(nc2)C(F)(F)F)n[nH]c1=O
Show InChI InChI=1S/C12H10F3N3O2/c13-12(14,15)10-4-2-7(6-16-10)1-3-8-5-9(19)11(20)18-17-8/h2,4-6H,1,3H2,(H,17,19)(H,18,20)
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Takeda Pharmaceutical Company Limited

US Patent


Assay Description
The functional activity of compounds inhibiting the DAAO enzyme was determined by utilizing the co-product of the catalysis of D-Serine, H2O2 which c...


US Patent US10463663 (2019)

More data for this
Ligand-Target Pair
D-amino-acid oxidase


(Homo sapiens (Human))
BDBM210813
PNG
(US10463663, Example 51 | US9290456, 51 | US9931340...)
Show SMILES Oc1cc(CCC2CCOCC2)n[nH]c1=O
Show InChI InChI=1S/C11H16N2O3/c14-10-7-9(12-13-11(10)15)2-1-8-3-5-16-6-4-8/h7-8H,1-6H2,(H,12,14)(H,13,15)
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Takeda Pharmaceutical Company Limited

US Patent


Assay Description
The functional activity of compounds inhibiting the DAAO enzyme was determined by utilizing the co-product of the catalysis of D-Serine, H2O2 which c...


US Patent US10463663 (2019)

More data for this
Ligand-Target Pair
D-amino-acid oxidase


(Homo sapiens (Human))
BDBM50431075
PNG
(CHEMBL2338789 | US10202399, Example 40 | US1046366...)
Show SMILES Oc1cc(CCC2CCCCC2)n[nH]c1=O
Show InChI InChI=1S/C12H18N2O2/c15-11-8-10(13-14-12(11)16)7-6-9-4-2-1-3-5-9/h8-9H,1-7H2,(H,13,15)(H,14,16)
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n/an/a 31n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
The functional activity of compounds inhibiting the DAAO enzyme was determined by utilizing the co-product of the catalysis of D-Serine, H2O2 which c...


US Patent US10463663 (2019)

More data for this
Ligand-Target Pair
D-amino-acid oxidase


(Homo sapiens (Human))
BDBM50431077
PNG
(CHEMBL2338787 | US10202399, Example 48 | US1046366...)
Show SMILES CC(c1ccccc1)c1cc(O)c(=O)[nH]n1
Show InChI InChI=1/C12H12N2O2/c1-8(9-5-3-2-4-6-9)10-7-11(15)12(16)14-13-10/h2-8H,1H3,(H,13,15)(H,14,16)
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Takeda Pharmaceutical Company Limited

US Patent


Assay Description
The functional activity of compounds inhibiting the DAAO enzyme was determined by utilizing the co-product of the catalysis of D-Serine, H2O2 which c...


US Patent US10463663 (2019)

More data for this
Ligand-Target Pair
D-amino-acid oxidase


(Homo sapiens (Human))
BDBM210780
PNG
(US10463663, Example 14 | US9290456, 14 | US9931340...)
Show SMILES Oc1cc(CCC2CC2)n[nH]c1=O
Show InChI InChI=1S/C9H12N2O2/c12-8-5-7(10-11-9(8)13)4-3-6-1-2-6/h5-6H,1-4H2,(H,10,12)(H,11,13)
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Takeda Pharmaceutical Company Limited

US Patent


Assay Description
The functional activity of compounds inhibiting the DAAO enzyme was determined by utilizing the co-product of the catalysis of D-Serine, H2O2 which c...


US Patent US10463663 (2019)

More data for this
Ligand-Target Pair
D-amino-acid oxidase


(Homo sapiens (Human))
BDBM210798
PNG
(US10463663, Example 35 | US9290456, 35 | US9931340...)
Show SMILES CC(c1cccc(c1)C(F)(F)F)c1cc(O)c(=O)[nH]n1
Show InChI InChI=1/C13H11F3N2O2/c1-7(10-6-11(19)12(20)18-17-10)8-3-2-4-9(5-8)13(14,15)16/h2-7H,1H3,(H,17,19)(H,18,20)
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Takeda Pharmaceutical Company Limited

US Patent


Assay Description
The functional activity of compounds inhibiting the DAAO enzyme was determined by utilizing the co-product of the catalysis of D-Serine, H2O2 which c...


US Patent US10463663 (2019)

More data for this
Ligand-Target Pair
D-amino-acid oxidase


(Homo sapiens (Human))
BDBM210790
PNG
(US10463663, Example 25 | US9290456, 25 | US9931340...)
Show SMILES COc1ccc(CCc2cc(O)c(=O)[nH]n2)cc1OC
Show InChI InChI=1S/C14H16N2O4/c1-19-12-6-4-9(7-13(12)20-2)3-5-10-8-11(17)14(18)16-15-10/h4,6-8H,3,5H2,1-2H3,(H,15,17)(H,16,18)
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Takeda Pharmaceutical Company Limited

US Patent


Assay Description
The functional activity of compounds inhibiting the DAAO enzyme was determined by utilizing the co-product of the catalysis of D-Serine, H2O2 which c...


US Patent US10463663 (2019)

More data for this
Ligand-Target Pair
D-amino-acid oxidase


(Homo sapiens (Human))
BDBM50431068
PNG
(CHEMBL2338796 | US10202399, Example 30 | US1046366...)
Show SMILES Oc1cc(CCc2ccccc2C(F)(F)F)n[nH]c1=O
Show InChI InChI=1S/C13H11F3N2O2/c14-13(15,16)10-4-2-1-3-8(10)5-6-9-7-11(19)12(20)18-17-9/h1-4,7H,5-6H2,(H,17,19)(H,18,20)
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Takeda Pharmaceutical Company Limited

US Patent


Assay Description
The functional activity of compounds inhibiting the DAAO enzyme was determined by utilizing the co-product of the catalysis of D-Serine, H2O2 which c...


US Patent US10463663 (2019)

More data for this
Ligand-Target Pair
D-amino-acid oxidase


(Homo sapiens (Human))
BDBM419571
PNG
(US10463663, Example 16)
Show SMILES COC1CCC(CCc2cc(O)c(=O)[nH]n2)CC1
Show InChI InChI=1S/C13H20N2O3/c1-18-11-6-3-9(4-7-11)2-5-10-8-12(16)13(17)15-14-10/h8-9,11H,2-7H2,1H3,(H,14,16)(H,15,17)
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Takeda Pharmaceutical Company Limited

US Patent


Assay Description
The functional activity of compounds inhibiting the DAAO enzyme was determined by utilizing the co-product of the catalysis of D-Serine, H2O2 which c...


US Patent US10463663 (2019)

More data for this
Ligand-Target Pair
D-amino-acid oxidase


(Homo sapiens (Human))
BDBM50431082
PNG
(CHEMBL2338804 | US10202399, Example 19 | US1046366...)
Show SMILES Oc1cc(CCc2cc(cc(c2)C(F)(F)F)C(F)(F)F)n[nH]c1=O
Show InChI InChI=1S/C14H10F6N2O2/c15-13(16,17)8-3-7(4-9(5-8)14(18,19)20)1-2-10-6-11(23)12(24)22-21-10/h3-6H,1-2H2,(H,21,23)(H,22,24)
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Takeda Pharmaceutical Company Limited

US Patent


Assay Description
The functional activity of compounds inhibiting the DAAO enzyme was determined by utilizing the co-product of the catalysis of D-Serine, H2O2 which c...


US Patent US10463663 (2019)

More data for this
Ligand-Target Pair
D-amino-acid oxidase


(Homo sapiens (Human))
BDBM210819
PNG
(US10463663, Example 58 | US9290456, 58 | US9931340...)
Show SMILES Oc1cc(n[nH]c1=O)C1(CC1)c1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C14H11F3N2O2/c15-14(16,17)9-3-1-8(2-4-9)13(5-6-13)11-7-10(20)12(21)19-18-11/h1-4,7H,5-6H2,(H,18,20)(H,19,21)
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Takeda Pharmaceutical Company Limited

US Patent


Assay Description
The functional activity of compounds inhibiting the DAAO enzyme was determined by utilizing the co-product of the catalysis of D-Serine, H2O2 which c...


US Patent US10463663 (2019)

More data for this
Ligand-Target Pair
D-amino-acid oxidase


(Homo sapiens (Human))
BDBM210803
PNG
(US10463663, Example 41 | US9290456, 41 | US9931340...)
Show SMILES Oc1cc(CC2CCCCC2)n[nH]c1=O
Show InChI InChI=1S/C11H16N2O2/c14-10-7-9(12-13-11(10)15)6-8-4-2-1-3-5-8/h7-8H,1-6H2,(H,12,14)(H,13,15)
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Takeda Pharmaceutical Company Limited

US Patent


Assay Description
The functional activity of compounds inhibiting the DAAO enzyme was determined by utilizing the co-product of the catalysis of D-Serine, H2O2 which c...


US Patent US10463663 (2019)

More data for this
Ligand-Target Pair
D-amino-acid oxidase


(Homo sapiens (Human))
BDBM210814
PNG
(US10463663, Example 52 | US9290456, 52 | US9931340...)
Show SMILES CN(Cc1ccc(F)cc1)c1cc(O)c(=O)[nH]n1
Show InChI InChI=1S/C12H12FN3O2/c1-16(7-8-2-4-9(13)5-3-8)11-6-10(17)12(18)15-14-11/h2-6H,7H2,1H3,(H,14,17)(H,15,18)
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Takeda Pharmaceutical Company Limited

US Patent


Assay Description
The functional activity of compounds inhibiting the DAAO enzyme was determined by utilizing the co-product of the catalysis of D-Serine, H2O2 which c...


US Patent US10463663 (2019)

More data for this
Ligand-Target Pair
D-amino-acid oxidase


(Homo sapiens (Human))
BDBM210799
PNG
(US10463663, Example 37 | US9290456, 37 | US9931340...)
Show SMILES CN(CC1CC1)c1cc(O)c(=O)[nH]n1
Show InChI InChI=1S/C9H13N3O2/c1-12(5-6-2-3-6)8-4-7(13)9(14)11-10-8/h4,6H,2-3,5H2,1H3,(H,10,13)(H,11,14)
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Takeda Pharmaceutical Company Limited

US Patent


Assay Description
The functional activity of compounds inhibiting the DAAO enzyme was determined by utilizing the co-product of the catalysis of D-Serine, H2O2 which c...


US Patent US10463663 (2019)

More data for this
Ligand-Target Pair
D-amino-acid oxidase


(Homo sapiens (Human))
BDBM210818
PNG
(US10463663, Example 57 | US9290456, 57 | US9931340...)
Show SMILES Oc1cc(CC2CC2)n[nH]c1=O
Show InChI InChI=1S/C8H10N2O2/c11-7-4-6(3-5-1-2-5)9-10-8(7)12/h4-5H,1-3H2,(H,9,11)(H,10,12)
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Takeda Pharmaceutical Company Limited

US Patent


Assay Description
The functional activity of compounds inhibiting the DAAO enzyme was determined by utilizing the co-product of the catalysis of D-Serine, H2O2 which c...


US Patent US10463663 (2019)

More data for this
Ligand-Target Pair
D-amino-acid oxidase


(Homo sapiens (Human))
BDBM210817
PNG
(US10463663, Example 55 | US9290456, 55 | US9931340...)
Show SMILES Oc1cc(Cc2cc(cc(c2)C(F)(F)F)C(F)(F)F)n[nH]c1=O
Show InChI InChI=1S/C13H8F6N2O2/c14-12(15,16)7-1-6(2-8(4-7)13(17,18)19)3-9-5-10(22)11(23)21-20-9/h1-2,4-5H,3H2,(H,20,22)(H,21,23)
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US Patent
n/an/a 760n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
The functional activity of compounds inhibiting the DAAO enzyme was determined by utilizing the co-product of the catalysis of D-Serine, H2O2 which c...


US Patent US10463663 (2019)

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Ligand-Target Pair
* indicates data uncertainty>20%