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Patent code US10464911

Compile Data Set for Download or QSAR
Found 88 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Cereblon/Histone deacetylase 1


(Homo sapiens (Human))
BDBM419629
PNG
(US10464911, Example 56)
Show SMILES FC(F)c1nnc(o1)-c1ccc(CN(c2ccc(F)c(Cl)c2)S(=O)(=O)N2CCN(CC2)C2COC2)nc1
Show InChI InChI=1S/C22H22ClF3N6O4S/c23-18-9-16(3-4-19(18)24)32(37(33,34)31-7-5-30(6-8-31)17-12-35-13-17)11-15-2-1-14(10-27-15)21-28-29-22(36-21)20(25)26/h1-4,9-10,17,20H,5-8,11-13H2
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n/an/a 14n/an/an/an/an/an/a



Chong Kun Dang Pharmaceutical Corp.

US Patent


Assay Description
HDAC enzyme activity was measured using a HDAC Fluorimetric Drug Discovery Kit (BML-AK511, 516, Enzo Life Science). For the HDAC1 enzyme activity tes...


US Patent US10464911 (2019)

More data for this
Ligand-Target Pair
Cereblon/Histone deacetylase 1


(Homo sapiens (Human))
BDBM419605
PNG
(US10464911, Example 33)
Show SMILES CN1CCN(CC1)S(=O)(=O)N(Cc1ccc(cn1)-c1nnc(o1)C(F)F)c1ccccc1
Show InChI InChI=1S/C20H22F2N6O3S/c1-26-9-11-27(12-10-26)32(29,30)28(17-5-3-2-4-6-17)14-16-8-7-15(13-23-16)19-24-25-20(31-19)18(21)22/h2-8,13,18H,9-12,14H2,1H3
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n/an/a 15n/an/an/an/an/an/a



Chong Kun Dang Pharmaceutical Corp.

US Patent


Assay Description
HDAC enzyme activity was measured using a HDAC Fluorimetric Drug Discovery Kit (BML-AK511, 516, Enzo Life Science). For the HDAC1 enzyme activity tes...


US Patent US10464911 (2019)

More data for this
Ligand-Target Pair
Cereblon/Histone deacetylase 1


(Homo sapiens (Human))
BDBM419611
PNG
(US10464911, Example 39)
Show SMILES FC(F)c1nnc(o1)-c1ccc(CN(c2ccccc2)S(=O)(=O)N2CCN(CC2)C2COC2)nc1
Show InChI InChI=1S/C22H24F2N6O4S/c23-20(24)22-27-26-21(34-22)16-6-7-17(25-12-16)13-30(18-4-2-1-3-5-18)35(31,32)29-10-8-28(9-11-29)19-14-33-15-19/h1-7,12,19-20H,8-11,13-15H2
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n/an/a 16n/an/an/an/an/an/a



Chong Kun Dang Pharmaceutical Corp.

US Patent


Assay Description
HDAC enzyme activity was measured using a HDAC Fluorimetric Drug Discovery Kit (BML-AK511, 516, Enzo Life Science). For the HDAC1 enzyme activity tes...


US Patent US10464911 (2019)

More data for this
Ligand-Target Pair
Cereblon/Histone deacetylase 1


(Homo sapiens (Human))
BDBM419650
PNG
(US10464911, Example 73)
Show SMILES C[C@H]1CN(CCN1C1COC1)S(=O)(=O)N(Cc1ccc(cn1)-c1nnc(o1)C(F)F)c1cccc(Cl)c1
Show InChI InChI=1/C23H25ClF2N6O4S/c1-15-11-30(7-8-31(15)20-13-35-14-20)37(33,34)32(19-4-2-3-17(24)9-19)12-18-6-5-16(10-27-18)22-28-29-23(36-22)21(25)26/h2-6,9-10,15,20-21H,7-8,11-14H2,1H3/t15-/s2
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n/an/a 17n/an/an/an/an/an/a



Chong Kun Dang Pharmaceutical Corp.

US Patent


Assay Description
HDAC enzyme activity was measured using a HDAC Fluorimetric Drug Discovery Kit (BML-AK511, 516, Enzo Life Science). For the HDAC1 enzyme activity tes...


US Patent US10464911 (2019)

More data for this
Ligand-Target Pair
Cereblon/Histone deacetylase 1


(Homo sapiens (Human))
BDBM419607
PNG
(US10464911, Example 35)
Show SMILES FC(F)c1nnc(o1)-c1ccc(CN(c2ccccc2)S(=O)(=O)N2CCS(=O)(=O)CC2)nc1
Show InChI InChI=1S/C19H19F2N5O5S2/c20-17(21)19-24-23-18(31-19)14-6-7-15(22-12-14)13-26(16-4-2-1-3-5-16)33(29,30)25-8-10-32(27,28)11-9-25/h1-7,12,17H,8-11,13H2
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n/an/a 20n/an/an/an/an/an/a



Chong Kun Dang Pharmaceutical Corp.

US Patent


Assay Description
HDAC enzyme activity was measured using a HDAC Fluorimetric Drug Discovery Kit (BML-AK511, 516, Enzo Life Science). For the HDAC1 enzyme activity tes...


US Patent US10464911 (2019)

More data for this
Ligand-Target Pair
Cereblon/Histone deacetylase 1


(Homo sapiens (Human))
BDBM419626
PNG
(US10464911, Example 54)
Show SMILES CC(C)N1CCN(CC1)S(=O)(=O)N(Cc1ccc(cn1)-c1nnc(o1)C(F)F)c1ccc(F)c(Cl)c1
Show InChI InChI=1S/C22H24ClF3N6O3S/c1-14(2)30-7-9-31(10-8-30)36(33,34)32(17-5-6-19(24)18(23)11-17)13-16-4-3-15(12-27-16)21-28-29-22(35-21)20(25)26/h3-6,11-12,14,20H,7-10,13H2,1-2H3
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n/an/a 21n/an/an/an/an/an/a



Chong Kun Dang Pharmaceutical Corp.

US Patent


Assay Description
HDAC enzyme activity was measured using a HDAC Fluorimetric Drug Discovery Kit (BML-AK511, 516, Enzo Life Science). For the HDAC1 enzyme activity tes...


US Patent US10464911 (2019)

More data for this
Ligand-Target Pair
Cereblon/Histone deacetylase 1


(Homo sapiens (Human))
BDBM419653
PNG
(US10464911, Example 75)
Show SMILES FC(F)c1nnc(o1)-c1ccc(CN(c2cccc(Cl)c2)S(=O)(=O)N2CCN(CC2)C2COC2)nc1
Show InChI InChI=1S/C22H23ClF2N6O4S/c23-16-2-1-3-18(10-16)31(36(32,33)30-8-6-29(7-9-30)19-13-34-14-19)12-17-5-4-15(11-26-17)21-27-28-22(35-21)20(24)25/h1-5,10-11,19-20H,6-9,12-14H2
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n/an/a 21n/an/an/an/an/an/a



Chong Kun Dang Pharmaceutical Corp.

US Patent


Assay Description
HDAC enzyme activity was measured using a HDAC Fluorimetric Drug Discovery Kit (BML-AK511, 516, Enzo Life Science). For the HDAC1 enzyme activity tes...


US Patent US10464911 (2019)

More data for this
Ligand-Target Pair
Cereblon/Histone deacetylase 1


(Homo sapiens (Human))
BDBM419608
PNG
(US10464911, Example 36)
Show SMILES FC(F)c1nnc(o1)-c1ccc(CN(c2ccc(F)c(Cl)c2)S(=O)(=O)N2CCS(=O)(=O)CC2)nc1
Show InChI InChI=1S/C19H17ClF3N5O5S2/c20-15-9-14(3-4-16(15)21)28(35(31,32)27-5-7-34(29,30)8-6-27)11-13-2-1-12(10-24-13)18-25-26-19(33-18)17(22)23/h1-4,9-10,17H,5-8,11H2
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n/an/a 23n/an/an/an/an/an/a



Chong Kun Dang Pharmaceutical Corp.

US Patent


Assay Description
HDAC enzyme activity was measured using a HDAC Fluorimetric Drug Discovery Kit (BML-AK511, 516, Enzo Life Science). For the HDAC1 enzyme activity tes...


US Patent US10464911 (2019)

More data for this
Ligand-Target Pair
Cereblon/Histone deacetylase 1


(Homo sapiens (Human))
BDBM419584
PNG
(US10464911, Example 16)
Show SMILES CN1CCN(CC1)S(=O)(=O)N(Cc1ccc(cc1F)-c1nnc(o1)C(F)F)c1ccccc1
Show InChI InChI=1S/C21H22F3N5O3S/c1-27-9-11-28(12-10-27)33(30,31)29(17-5-3-2-4-6-17)14-16-8-7-15(13-18(16)22)20-25-26-21(32-20)19(23)24/h2-8,13,19H,9-12,14H2,1H3
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n/an/a 23n/an/an/an/an/an/a



Chong Kun Dang Pharmaceutical Corp.

US Patent


Assay Description
HDAC enzyme activity was measured using a HDAC Fluorimetric Drug Discovery Kit (BML-AK511, 516, Enzo Life Science). For the HDAC1 enzyme activity tes...


US Patent US10464911 (2019)

More data for this
Ligand-Target Pair
Cereblon/Histone deacetylase 1


(Homo sapiens (Human))
BDBM419593
PNG
(US10464911, Example 23)
Show SMILES FC(F)c1nnc(o1)-c1ccc(CN(c2cccc(F)c2)S(=O)(=O)N2CCNCC2)c(F)c1
Show InChI InChI=1S/C20H19F4N5O3S/c21-15-2-1-3-16(11-15)29(33(30,31)28-8-6-25-7-9-28)12-14-5-4-13(10-17(14)22)19-26-27-20(32-19)18(23)24/h1-5,10-11,18,25H,6-9,12H2
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n/an/a 24n/an/an/an/an/an/a



Chong Kun Dang Pharmaceutical Corp.

US Patent


Assay Description
HDAC enzyme activity was measured using a HDAC Fluorimetric Drug Discovery Kit (BML-AK511, 516, Enzo Life Science). For the HDAC1 enzyme activity tes...


US Patent US10464911 (2019)

More data for this
Ligand-Target Pair
Cereblon/Histone deacetylase 1


(Homo sapiens (Human))
BDBM419598
PNG
(US10464911, Example 26)
Show SMILES CN1CCN(CC1)S(=O)(=O)N(Cc1ccc(cc1F)-c1nnc(o1)C(F)F)c1cccc(F)c1
Show InChI InChI=1S/C21H21F4N5O3S/c1-28-7-9-29(10-8-28)34(31,32)30(17-4-2-3-16(22)12-17)13-15-6-5-14(11-18(15)23)20-26-27-21(33-20)19(24)25/h2-6,11-12,19H,7-10,13H2,1H3
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n/an/a 25n/an/an/an/an/an/a



Chong Kun Dang Pharmaceutical Corp.

US Patent


Assay Description
HDAC enzyme activity was measured using a HDAC Fluorimetric Drug Discovery Kit (BML-AK511, 516, Enzo Life Science). For the HDAC1 enzyme activity tes...


US Patent US10464911 (2019)

More data for this
Ligand-Target Pair
Cereblon/Histone deacetylase 1


(Homo sapiens (Human))
BDBM419606
PNG
(US10464911, Example 34)
Show SMILES FC(F)c1nnc(o1)-c1ccc(CN(c2ccccc2)S(=O)(=O)N2CCN(CC2)C2COC2)c(F)c1
Show InChI InChI=1S/C23H24F3N5O4S/c24-20-12-16(22-27-28-23(35-22)21(25)26)6-7-17(20)13-31(18-4-2-1-3-5-18)36(32,33)30-10-8-29(9-11-30)19-14-34-15-19/h1-7,12,19,21H,8-11,13-15H2
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n/an/a 26n/an/an/an/an/an/a



Chong Kun Dang Pharmaceutical Corp.

US Patent


Assay Description
HDAC enzyme activity was measured using a HDAC Fluorimetric Drug Discovery Kit (BML-AK511, 516, Enzo Life Science). For the HDAC1 enzyme activity tes...


US Patent US10464911 (2019)

More data for this
Ligand-Target Pair
Cereblon/Histone deacetylase 1


(Homo sapiens (Human))
BDBM419622
PNG
(US10464911, Example 50)
Show SMILES C[C@H]1CN(C[C@@H](C)N1C(C)=O)S(=O)(=O)N(Cc1ccc(cn1)-c1nnc(o1)C(F)F)c1ccccc1
Show InChI InChI=1/C23H26F2N6O4S/c1-15-12-29(13-16(2)31(15)17(3)32)36(33,34)30(20-7-5-4-6-8-20)14-19-10-9-18(11-26-19)22-27-28-23(35-22)21(24)25/h4-11,15-16,21H,12-14H2,1-3H3/t15-,16+
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n/an/a 26n/an/an/an/an/an/a



Chong Kun Dang Pharmaceutical Corp.

US Patent


Assay Description
HDAC enzyme activity was measured using a HDAC Fluorimetric Drug Discovery Kit (BML-AK511, 516, Enzo Life Science). For the HDAC1 enzyme activity tes...


US Patent US10464911 (2019)

More data for this
Ligand-Target Pair
Cereblon/Histone deacetylase 1


(Homo sapiens (Human))
BDBM419627
PNG
(US10464911, Example 55)
Show SMILES FC(F)c1nnc(o1)-c1ccc(CN(c2ccc(F)c(Cl)c2)S(=O)(=O)N2CCN(CC2)C2CCC2)nc1
Show InChI InChI=1S/C23H24ClF3N6O3S/c24-19-12-18(6-7-20(19)25)33(37(34,35)32-10-8-31(9-11-32)17-2-1-3-17)14-16-5-4-15(13-28-16)22-29-30-23(36-22)21(26)27/h4-7,12-13,17,21H,1-3,8-11,14H2
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n/an/a 27n/an/an/an/an/an/a



Chong Kun Dang Pharmaceutical Corp.

US Patent


Assay Description
HDAC enzyme activity was measured using a HDAC Fluorimetric Drug Discovery Kit (BML-AK511, 516, Enzo Life Science). For the HDAC1 enzyme activity tes...


US Patent US10464911 (2019)

More data for this
Ligand-Target Pair
Cereblon/Histone deacetylase 1


(Homo sapiens (Human))
BDBM419579
PNG
(US10464911, Example 11)
Show SMILES FC(F)c1nnc(o1)-c1ccc(CN(c2ccccc2)S(=O)(=O)N2CCNCC2)c(F)c1
Show InChI InChI=1S/C20H20F3N5O3S/c21-17-12-14(19-25-26-20(31-19)18(22)23)6-7-15(17)13-28(16-4-2-1-3-5-16)32(29,30)27-10-8-24-9-11-27/h1-7,12,18,24H,8-11,13H2
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n/an/a 28n/an/an/an/an/an/a



Chong Kun Dang Pharmaceutical Corp.

US Patent


Assay Description
HDAC enzyme activity was measured using a HDAC Fluorimetric Drug Discovery Kit (BML-AK511, 516, Enzo Life Science). For the HDAC1 enzyme activity tes...


US Patent US10464911 (2019)

More data for this
Ligand-Target Pair
Cereblon/Histone deacetylase 1


(Homo sapiens (Human))
BDBM419648
PNG
(US10464911, Example 72)
Show SMILES C[C@H]1CN(CCN1C)S(=O)(=O)N(Cc1ccc(cn1)-c1nnc(o1)C(F)F)c1cccc(Cl)c1
Show InChI InChI=1/C21H23ClF2N6O3S/c1-14-12-29(9-8-28(14)2)34(31,32)30(18-5-3-4-16(22)10-18)13-17-7-6-15(11-25-17)20-26-27-21(33-20)19(23)24/h3-7,10-11,14,19H,8-9,12-13H2,1-2H3/t14-/s2
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n/an/a 29n/an/an/an/an/an/a



Chong Kun Dang Pharmaceutical Corp.

US Patent


Assay Description
HDAC enzyme activity was measured using a HDAC Fluorimetric Drug Discovery Kit (BML-AK511, 516, Enzo Life Science). For the HDAC1 enzyme activity tes...


US Patent US10464911 (2019)

More data for this
Ligand-Target Pair
Cereblon/Histone deacetylase 1


(Homo sapiens (Human))
BDBM419597
PNG
(US10464911, Example 25)
Show SMILES CC(=O)N1CCN(CC1)S(=O)(=O)N(Cc1ccc(cc1F)-c1nnc(o1)C(F)F)c1cccc(F)c1
Show InChI InChI=1S/C22H21F4N5O4S/c1-14(32)29-7-9-30(10-8-29)36(33,34)31(18-4-2-3-17(23)12-18)13-16-6-5-15(11-19(16)24)21-27-28-22(35-21)20(25)26/h2-6,11-12,20H,7-10,13H2,1H3
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n/an/a 30n/an/an/an/an/an/a



Chong Kun Dang Pharmaceutical Corp.

US Patent


Assay Description
HDAC enzyme activity was measured using a HDAC Fluorimetric Drug Discovery Kit (BML-AK511, 516, Enzo Life Science). For the HDAC1 enzyme activity tes...


US Patent US10464911 (2019)

More data for this
Ligand-Target Pair
Cereblon/Histone deacetylase 1


(Homo sapiens (Human))
BDBM419581
PNG
(US10464911, Example 13)
Show SMILES CCC(=O)N1CCN(CC1)S(=O)(=O)N(Cc1ccc(cc1F)-c1nnc(o1)C(F)F)c1ccccc1
Show InChI InChI=1S/C23H24F3N5O4S/c1-2-20(32)29-10-12-30(13-11-29)36(33,34)31(18-6-4-3-5-7-18)15-17-9-8-16(14-19(17)24)22-27-28-23(35-22)21(25)26/h3-9,14,21H,2,10-13,15H2,1H3
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n/an/a 31n/an/an/an/an/an/a



Chong Kun Dang Pharmaceutical Corp.

US Patent


Assay Description
HDAC enzyme activity was measured using a HDAC Fluorimetric Drug Discovery Kit (BML-AK511, 516, Enzo Life Science). For the HDAC1 enzyme activity tes...


US Patent US10464911 (2019)

More data for this
Ligand-Target Pair
Cereblon/Histone deacetylase 1


(Homo sapiens (Human))
BDBM419580
PNG
(US10464911, Example 12)
Show SMILES CC(=O)N1CCN(CC1)S(=O)(=O)N(Cc1ccc(cc1F)-c1nnc(o1)C(F)F)c1ccccc1
Show InChI InChI=1S/C22H22F3N5O4S/c1-15(31)28-9-11-29(12-10-28)35(32,33)30(18-5-3-2-4-6-18)14-17-8-7-16(13-19(17)23)21-26-27-22(34-21)20(24)25/h2-8,13,20H,9-12,14H2,1H3
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n/an/a 32n/an/an/an/an/an/a



Chong Kun Dang Pharmaceutical Corp.

US Patent


Assay Description
HDAC enzyme activity was measured using a HDAC Fluorimetric Drug Discovery Kit (BML-AK511, 516, Enzo Life Science). For the HDAC1 enzyme activity tes...


US Patent US10464911 (2019)

More data for this
Ligand-Target Pair
Cereblon/Histone deacetylase 1


(Homo sapiens (Human))
BDBM419596
PNG
(US10464911, Example 24)
Show SMILES CS(=O)(=O)N1CCN(CC1)S(=O)(=O)N(Cc1ccc(cc1F)-c1nnc(o1)C(F)F)c1cccc(F)c1
Show InChI InChI=1S/C21H21F4N5O5S2/c1-36(31,32)28-7-9-29(10-8-28)37(33,34)30(17-4-2-3-16(22)12-17)13-15-6-5-14(11-18(15)23)20-26-27-21(35-20)19(24)25/h2-6,11-12,19H,7-10,13H2,1H3
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n/an/a 33n/an/an/an/an/an/a



Chong Kun Dang Pharmaceutical Corp.

US Patent


Assay Description
HDAC enzyme activity was measured using a HDAC Fluorimetric Drug Discovery Kit (BML-AK511, 516, Enzo Life Science). For the HDAC1 enzyme activity tes...


US Patent US10464911 (2019)

More data for this
Ligand-Target Pair
Cereblon/Histone deacetylase 1


(Homo sapiens (Human))
BDBM419614
PNG
(US10464911, Example 42)
Show SMILES C[C@H]1CN(C[C@@H](C)N1C(C)=O)S(=O)(=O)N(Cc1ccc(cc1)-c1nnc(o1)C(F)F)c1ccccc1
Show InChI InChI=1/C24H27F2N5O4S/c1-16-13-29(14-17(2)31(16)18(3)32)36(33,34)30(21-7-5-4-6-8-21)15-19-9-11-20(12-10-19)23-27-28-24(35-23)22(25)26/h4-12,16-17,22H,13-15H2,1-3H3/t16-,17+
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n/an/a 33n/an/an/an/an/an/a



Chong Kun Dang Pharmaceutical Corp.

US Patent


Assay Description
HDAC enzyme activity was measured using a HDAC Fluorimetric Drug Discovery Kit (BML-AK511, 516, Enzo Life Science). For the HDAC1 enzyme activity tes...


US Patent US10464911 (2019)

More data for this
Ligand-Target Pair
Cereblon/Histone deacetylase 1


(Homo sapiens (Human))
BDBM419621
PNG
(US10464911, Example 49)
Show SMILES CN1CCN(CC1)S(=O)(=O)N(Cc1ccc(cc1)-c1nnc(o1)C(F)F)c1ccc(F)c(Cl)c1
Show InChI InChI=1S/C21H21ClF3N5O3S/c1-28-8-10-29(11-9-28)34(31,32)30(16-6-7-18(23)17(22)12-16)13-14-2-4-15(5-3-14)20-26-27-21(33-20)19(24)25/h2-7,12,19H,8-11,13H2,1H3
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n/an/a 36n/an/an/an/an/an/a



Chong Kun Dang Pharmaceutical Corp.

US Patent


Assay Description
HDAC enzyme activity was measured using a HDAC Fluorimetric Drug Discovery Kit (BML-AK511, 516, Enzo Life Science). For the HDAC1 enzyme activity tes...


US Patent US10464911 (2019)

More data for this
Ligand-Target Pair
Cereblon/Histone deacetylase 1


(Homo sapiens (Human))
BDBM419644
PNG
(US10464911, Example 68)
Show SMILES C[C@@H]1CN(CCN1C)S(=O)(=O)N(Cc1ccc(cn1)-c1nnc(o1)C(F)F)c1cccc(Cl)c1
Show InChI InChI=1/C21H23ClF2N6O3S/c1-14-12-29(9-8-28(14)2)34(31,32)30(18-5-3-4-16(22)10-18)13-17-7-6-15(11-25-17)20-26-27-21(33-20)19(23)24/h3-7,10-11,14,19H,8-9,12-13H2,1-2H3/t14-/s2
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n/an/a 36n/an/an/an/an/an/a



Chong Kun Dang Pharmaceutical Corp.

US Patent


Assay Description
HDAC enzyme activity was measured using a HDAC Fluorimetric Drug Discovery Kit (BML-AK511, 516, Enzo Life Science). For the HDAC1 enzyme activity tes...


US Patent US10464911 (2019)

More data for this
Ligand-Target Pair
Cereblon/Histone deacetylase 1


(Homo sapiens (Human))
BDBM419651
PNG
(US10464911, Example 74)
Show SMILES FC(F)c1nnc(o1)-c1ccc(CN(c2cccc(Cl)c2)S(=O)(=O)N2CCN(CC2)C2CCC2)nc1
Show InChI InChI=1S/C23H25ClF2N6O3S/c24-17-3-1-6-20(13-17)32(36(33,34)31-11-9-30(10-12-31)19-4-2-5-19)15-18-8-7-16(14-27-18)22-28-29-23(35-22)21(25)26/h1,3,6-8,13-14,19,21H,2,4-5,9-12,15H2
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n/an/a 36n/an/an/an/an/an/a



Chong Kun Dang Pharmaceutical Corp.

US Patent


Assay Description
HDAC enzyme activity was measured using a HDAC Fluorimetric Drug Discovery Kit (BML-AK511, 516, Enzo Life Science). For the HDAC1 enzyme activity tes...


US Patent US10464911 (2019)

More data for this
Ligand-Target Pair
Cereblon/Histone deacetylase 1


(Homo sapiens (Human))
BDBM419583
PNG
(US10464911, Example 15)
Show SMILES CS(=O)(=O)N1CCN(CC1)S(=O)(=O)N(Cc1ccc(cc1F)-c1nnc(o1)C(F)F)c1ccccc1
Show InChI InChI=1S/C21H22F3N5O5S2/c1-35(30,31)27-9-11-28(12-10-27)36(32,33)29(17-5-3-2-4-6-17)14-16-8-7-15(13-18(16)22)20-25-26-21(34-20)19(23)24/h2-8,13,19H,9-12,14H2,1H3
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n/an/a 38n/an/an/an/an/an/a



Chong Kun Dang Pharmaceutical Corp.

US Patent


Assay Description
HDAC enzyme activity was measured using a HDAC Fluorimetric Drug Discovery Kit (BML-AK511, 516, Enzo Life Science). For the HDAC1 enzyme activity tes...


US Patent US10464911 (2019)

More data for this
Ligand-Target Pair
Cereblon/Histone deacetylase 1


(Homo sapiens (Human))
BDBM419645
PNG
(US10464911, Example 69)
Show SMILES C[C@@H]1CN(CCN1C1COC1)S(=O)(=O)N(Cc1ccc(cn1)-c1nnc(o1)C(F)F)c1cccc(Cl)c1
Show InChI InChI=1/C23H25ClF2N6O4S/c1-15-11-30(7-8-31(15)20-13-35-14-20)37(33,34)32(19-4-2-3-17(24)9-19)12-18-6-5-16(10-27-18)22-28-29-23(36-22)21(25)26/h2-6,9-10,15,20-21H,7-8,11-14H2,1H3/t15-/s2
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n/an/a 41n/an/an/an/an/an/a



Chong Kun Dang Pharmaceutical Corp.

US Patent


Assay Description
HDAC enzyme activity was measured using a HDAC Fluorimetric Drug Discovery Kit (BML-AK511, 516, Enzo Life Science). For the HDAC1 enzyme activity tes...


US Patent US10464911 (2019)

More data for this
Ligand-Target Pair
Cereblon/Histone deacetylase 1


(Homo sapiens (Human))
BDBM419647
PNG
(US10464911, Example 71)
Show SMILES C[C@H]1CN(CCN1C1COC1)S(=O)(=O)N(Cc1ccc(cn1)-c1nnc(o1)C(F)F)c1cccc(C)c1
Show InChI InChI=1/C24H28F2N6O4S/c1-16-4-3-5-20(10-16)32(37(33,34)30-8-9-31(17(2)12-30)21-14-35-15-21)13-19-7-6-18(11-27-19)23-28-29-24(36-23)22(25)26/h3-7,10-11,17,21-22H,8-9,12-15H2,1-2H3/t17-/s2
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n/an/a 42n/an/an/an/an/an/a



Chong Kun Dang Pharmaceutical Corp.

US Patent


Assay Description
HDAC enzyme activity was measured using a HDAC Fluorimetric Drug Discovery Kit (BML-AK511, 516, Enzo Life Science). For the HDAC1 enzyme activity tes...


US Patent US10464911 (2019)

More data for this
Ligand-Target Pair
Cereblon/Histone deacetylase 1


(Homo sapiens (Human))
BDBM419587
PNG
(US10464911, Example 17)
Show SMILES CCN1CCN(CC1)S(=O)(=O)N(Cc1ccc(cc1F)-c1nnc(o1)C(F)F)c1ccccc1
Show InChI InChI=1S/C22H24F3N5O3S/c1-2-28-10-12-29(13-11-28)34(31,32)30(18-6-4-3-5-7-18)15-17-9-8-16(14-19(17)23)21-26-27-22(33-21)20(24)25/h3-9,14,20H,2,10-13,15H2,1H3
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n/an/a 42n/an/an/an/an/an/a



Chong Kun Dang Pharmaceutical Corp.

US Patent


Assay Description
HDAC enzyme activity was measured using a HDAC Fluorimetric Drug Discovery Kit (BML-AK511, 516, Enzo Life Science). For the HDAC1 enzyme activity tes...


US Patent US10464911 (2019)

More data for this
Ligand-Target Pair
Cereblon/Histone deacetylase 1


(Homo sapiens (Human))
BDBM419620
PNG
(US10464911, Example 48)
Show SMILES FC(F)c1nnc(o1)-c1ccc(CN(c2ccc(F)c(Cl)c2)S(=O)(=O)N2CCN(CC2)C2COC2)cc1
Show InChI InChI=1S/C23H23ClF3N5O4S/c24-19-11-17(5-6-20(19)25)32(37(33,34)31-9-7-30(8-10-31)18-13-35-14-18)12-15-1-3-16(4-2-15)22-28-29-23(36-22)21(26)27/h1-6,11,18,21H,7-10,12-14H2
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n/an/a 43n/an/an/an/an/an/a



Chong Kun Dang Pharmaceutical Corp.

US Patent


Assay Description
HDAC enzyme activity was measured using a HDAC Fluorimetric Drug Discovery Kit (BML-AK511, 516, Enzo Life Science). For the HDAC1 enzyme activity tes...


US Patent US10464911 (2019)

More data for this
Ligand-Target Pair
Cereblon/Histone deacetylase 1


(Homo sapiens (Human))
BDBM419600
PNG
(US10464911, Example 28)
Show SMILES CC(=O)N1CCN(CC1)S(=O)(=O)N(Cc1ccc(cc1F)-c1nnc(o1)C(F)F)c1cccnc1
Show InChI InChI=1S/C21H21F3N6O4S/c1-14(31)28-7-9-29(10-8-28)35(32,33)30(17-3-2-6-25-12-17)13-16-5-4-15(11-18(16)22)20-26-27-21(34-20)19(23)24/h2-6,11-12,19H,7-10,13H2,1H3
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n/an/a 43n/an/an/an/an/an/a



Chong Kun Dang Pharmaceutical Corp.

US Patent


Assay Description
HDAC enzyme activity was measured using a HDAC Fluorimetric Drug Discovery Kit (BML-AK511, 516, Enzo Life Science). For the HDAC1 enzyme activity tes...


US Patent US10464911 (2019)

More data for this
Ligand-Target Pair
Cereblon/Histone deacetylase 1


(Homo sapiens (Human))
BDBM419603
PNG
(US10464911, Example 31)
Show SMILES Fc1cc(ccc1CN(c1cccnc1)S(=O)(=O)N1CCNCC1)-c1nnc(o1)C(F)(F)F
Show InChI InChI=1S/C19H18F4N6O3S/c20-16-10-13(17-26-27-18(32-17)19(21,22)23)3-4-14(16)12-29(15-2-1-5-25-11-15)33(30,31)28-8-6-24-7-9-28/h1-5,10-11,24H,6-9,12H2
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n/an/a 44n/an/an/an/an/an/a



Chong Kun Dang Pharmaceutical Corp.

US Patent


Assay Description
HDAC enzyme activity was measured using a HDAC Fluorimetric Drug Discovery Kit (BML-AK511, 516, Enzo Life Science). For the HDAC1 enzyme activity tes...


US Patent US10464911 (2019)

More data for this
Ligand-Target Pair
Cereblon/Histone deacetylase 1


(Homo sapiens (Human))
BDBM419588
PNG
(US10464911, Example 18)
Show SMILES CC(C)N1CCN(CC1)S(=O)(=O)N(Cc1ccc(cc1F)-c1nnc(o1)C(F)F)c1ccccc1
Show InChI InChI=1S/C23H26F3N5O3S/c1-16(2)29-10-12-30(13-11-29)35(32,33)31(19-6-4-3-5-7-19)15-18-9-8-17(14-20(18)24)22-27-28-23(34-22)21(25)26/h3-9,14,16,21H,10-13,15H2,1-2H3
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n/an/a 46n/an/an/an/an/an/a



Chong Kun Dang Pharmaceutical Corp.

US Patent


Assay Description
HDAC enzyme activity was measured using a HDAC Fluorimetric Drug Discovery Kit (BML-AK511, 516, Enzo Life Science). For the HDAC1 enzyme activity tes...


US Patent US10464911 (2019)

More data for this
Ligand-Target Pair
Cereblon/Histone deacetylase 1


(Homo sapiens (Human))
BDBM419625
PNG
(US10464911, Example 53)
Show SMILES C[C@H]1CN(C[C@@H](C)N1C)S(=O)(=O)N(Cc1ccc(cc1)-c1nnc(o1)C(F)F)c1cccnc1
Show InChI InChI=1/C22H26F2N6O3S/c1-15-12-29(13-16(2)28(15)3)34(31,32)30(19-5-4-10-25-11-19)14-17-6-8-18(9-7-17)21-26-27-22(33-21)20(23)24/h4-11,15-16,20H,12-14H2,1-3H3/t15-,16+
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n/an/a 47n/an/an/an/an/an/a



Chong Kun Dang Pharmaceutical Corp.

US Patent


Assay Description
HDAC enzyme activity was measured using a HDAC Fluorimetric Drug Discovery Kit (BML-AK511, 516, Enzo Life Science). For the HDAC1 enzyme activity tes...


US Patent US10464911 (2019)

More data for this
Ligand-Target Pair
Cereblon/Histone deacetylase 1


(Homo sapiens (Human))
BDBM419612
PNG
(US10464911, Example 40)
Show SMILES FC(F)c1nnc(o1)-c1ccc(CN(c2ccccc2)S(=O)(=O)N2CCN(CC2)C2COC2)cc1
Show InChI InChI=1S/C23H25F2N5O4S/c24-21(25)23-27-26-22(34-23)18-8-6-17(7-9-18)14-30(19-4-2-1-3-5-19)35(31,32)29-12-10-28(11-13-29)20-15-33-16-20/h1-9,20-21H,10-16H2
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n/an/a 48n/an/an/an/an/an/a



Chong Kun Dang Pharmaceutical Corp.

US Patent


Assay Description
HDAC enzyme activity was measured using a HDAC Fluorimetric Drug Discovery Kit (BML-AK511, 516, Enzo Life Science). For the HDAC1 enzyme activity tes...


US Patent US10464911 (2019)

More data for this
Ligand-Target Pair
Cereblon/Histone deacetylase 1


(Homo sapiens (Human))
BDBM419642
PNG
(US10464911, Example 66)
Show SMILES C[C@@H]1CN(CCN1C)S(=O)(=O)N(Cc1ccc(cn1)-c1nnc(o1)C(F)F)c1cccc(C)c1
Show InChI InChI=1/C22H26F2N6O3S/c1-15-5-4-6-19(11-15)30(34(31,32)29-10-9-28(3)16(2)13-29)14-18-8-7-17(12-25-18)21-26-27-22(33-21)20(23)24/h4-8,11-12,16,20H,9-10,13-14H2,1-3H3/t16-/s2
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n/an/a 48n/an/an/an/an/an/a



Chong Kun Dang Pharmaceutical Corp.

US Patent


Assay Description
HDAC enzyme activity was measured using a HDAC Fluorimetric Drug Discovery Kit (BML-AK511, 516, Enzo Life Science). For the HDAC1 enzyme activity tes...


US Patent US10464911 (2019)

More data for this
Ligand-Target Pair
Cereblon/Histone deacetylase 1


(Homo sapiens (Human))
BDBM419654
PNG
(US10464911, Example 76)
Show SMILES Cc1cccc(c1)N(Cc1ccc(cn1)-c1nnc(o1)C(F)F)S(=O)(=O)N1CCN(CC1)C1COC1
Show InChI InChI=1S/C23H26F2N6O4S/c1-16-3-2-4-19(11-16)31(36(32,33)30-9-7-29(8-10-30)20-14-34-15-20)13-18-6-5-17(12-26-18)22-27-28-23(35-22)21(24)25/h2-6,11-12,20-21H,7-10,13-15H2,1H3
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n/an/a 49n/an/an/an/an/an/a



Chong Kun Dang Pharmaceutical Corp.

US Patent


Assay Description
HDAC enzyme activity was measured using a HDAC Fluorimetric Drug Discovery Kit (BML-AK511, 516, Enzo Life Science). For the HDAC1 enzyme activity tes...


US Patent US10464911 (2019)

More data for this
Ligand-Target Pair
Cereblon/Histone deacetylase 1


(Homo sapiens (Human))
BDBM419643
PNG
(US10464911, Example 67)
Show SMILES C[C@@H]1CN(CCN1C1COC1)S(=O)(=O)N(Cc1ccc(cn1)-c1nnc(o1)C(F)F)c1cccc(C)c1
Show InChI InChI=1/C24H28F2N6O4S/c1-16-4-3-5-20(10-16)32(37(33,34)30-8-9-31(17(2)12-30)21-14-35-15-21)13-19-7-6-18(11-27-19)23-28-29-24(36-23)22(25)26/h3-7,10-11,17,21-22H,8-9,12-15H2,1-2H3/t17-/s2
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n/an/a 50n/an/an/an/an/an/a



Chong Kun Dang Pharmaceutical Corp.

US Patent


Assay Description
HDAC enzyme activity was measured using a HDAC Fluorimetric Drug Discovery Kit (BML-AK511, 516, Enzo Life Science). For the HDAC1 enzyme activity tes...


US Patent US10464911 (2019)

More data for this
Ligand-Target Pair
Cereblon/Histone deacetylase 1


(Homo sapiens (Human))
BDBM419568
PNG
(US10464911, Example 2)
Show SMILES FC(F)c1nnc(o1)-c1ccc(CN(c2ccc(F)cc2)S(=O)(=O)N2CCOCC2)cc1
Show InChI InChI=1S/C20H19F3N4O4S/c21-16-5-7-17(8-6-16)27(32(28,29)26-9-11-30-12-10-26)13-14-1-3-15(4-2-14)19-24-25-20(31-19)18(22)23/h1-8,18H,9-13H2
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n/an/a 52n/an/an/an/an/an/a



Chong Kun Dang Pharmaceutical Corp.

US Patent


Assay Description
HDAC enzyme activity was measured using a HDAC Fluorimetric Drug Discovery Kit (BML-AK511, 516, Enzo Life Science). For the HDAC1 enzyme activity tes...


US Patent US10464911 (2019)

More data for this
Ligand-Target Pair
Cereblon/Histone deacetylase 1


(Homo sapiens (Human))
BDBM419582
PNG
(US10464911, Example 14)
Show SMILES CC(C)C(=O)N1CCN(CC1)S(=O)(=O)N(Cc1ccc(cc1F)-c1nnc(o1)C(F)F)c1ccccc1
Show InChI InChI=1S/C24H26F3N5O4S/c1-16(2)24(33)30-10-12-31(13-11-30)37(34,35)32(19-6-4-3-5-7-19)15-18-9-8-17(14-20(18)25)22-28-29-23(36-22)21(26)27/h3-9,14,16,21H,10-13,15H2,1-2H3
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n/an/a 52n/an/an/an/an/an/a



Chong Kun Dang Pharmaceutical Corp.

US Patent


Assay Description
HDAC enzyme activity was measured using a HDAC Fluorimetric Drug Discovery Kit (BML-AK511, 516, Enzo Life Science). For the HDAC1 enzyme activity tes...


US Patent US10464911 (2019)

More data for this
Ligand-Target Pair
Cereblon/Histone deacetylase 1


(Homo sapiens (Human))
BDBM419646
PNG
(US10464911, Example 70)
Show SMILES C[C@H]1CN(CCN1C)S(=O)(=O)N(Cc1ccc(cn1)-c1nnc(o1)C(F)F)c1cccc(C)c1
Show InChI InChI=1/C22H26F2N6O3S/c1-15-5-4-6-19(11-15)30(34(31,32)29-10-9-28(3)16(2)13-29)14-18-8-7-17(12-25-18)21-26-27-22(33-21)20(23)24/h4-8,11-12,16,20H,9-10,13-14H2,1-3H3/t16-/s2
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n/an/a 52n/an/an/an/an/an/a



Chong Kun Dang Pharmaceutical Corp.

US Patent


Assay Description
HDAC enzyme activity was measured using a HDAC Fluorimetric Drug Discovery Kit (BML-AK511, 516, Enzo Life Science). For the HDAC1 enzyme activity tes...


US Patent US10464911 (2019)

More data for this
Ligand-Target Pair
Cereblon/Histone deacetylase 1


(Homo sapiens (Human))
BDBM419602
PNG
(US10464911, Example 30)
Show SMILES CN1CCN(CC1)S(=O)(=O)N(Cc1ccc(cc1F)-c1nnc(o1)C(F)F)c1cccnc1
Show InChI InChI=1S/C20H21F3N6O3S/c1-27-7-9-28(10-8-27)33(30,31)29(16-3-2-6-24-12-16)13-15-5-4-14(11-17(15)21)19-25-26-20(32-19)18(22)23/h2-6,11-12,18H,7-10,13H2,1H3
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n/an/a 55n/an/an/an/an/an/a



Chong Kun Dang Pharmaceutical Corp.

US Patent


Assay Description
HDAC enzyme activity was measured using a HDAC Fluorimetric Drug Discovery Kit (BML-AK511, 516, Enzo Life Science). For the HDAC1 enzyme activity tes...


US Patent US10464911 (2019)

More data for this
Ligand-Target Pair
Cereblon/Histone deacetylase 1


(Homo sapiens (Human))
BDBM419589
PNG
(US10464911, Example 19)
Show SMILES Fc1cccc(c1)N(Cc1ccc(cc1F)-c1nnc(o1)C(F)(F)F)S(=O)(=O)N1CCNCC1
Show InChI InChI=1S/C20H18F5N5O3S/c21-15-2-1-3-16(11-15)30(34(31,32)29-8-6-26-7-9-29)12-14-5-4-13(10-17(14)22)18-27-28-19(33-18)20(23,24)25/h1-5,10-11,26H,6-9,12H2
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n/an/a 58n/an/an/an/an/an/a



Chong Kun Dang Pharmaceutical Corp.

US Patent


Assay Description
HDAC enzyme activity was measured using a HDAC Fluorimetric Drug Discovery Kit (BML-AK511, 516, Enzo Life Science). For the HDAC1 enzyme activity tes...


US Patent US10464911 (2019)

More data for this
Ligand-Target Pair
Cereblon/Histone deacetylase 1


(Homo sapiens (Human))
BDBM419624
PNG
(US10464911, Example 52)
Show SMILES CCN1[C@@H](C)CN(C[C@H]1C)S(=O)(=O)N(Cc1ccc(cn1)-c1nnc(o1)C(F)F)c1ccccc1
Show InChI InChI=1/C23H28F2N6O3S/c1-4-30-16(2)13-29(14-17(30)3)35(32,33)31(20-8-6-5-7-9-20)15-19-11-10-18(12-26-19)22-27-28-23(34-22)21(24)25/h5-12,16-17,21H,4,13-15H2,1-3H3/t16-,17+
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n/an/a 61n/an/an/an/an/an/a



Chong Kun Dang Pharmaceutical Corp.

US Patent


Assay Description
HDAC enzyme activity was measured using a HDAC Fluorimetric Drug Discovery Kit (BML-AK511, 516, Enzo Life Science). For the HDAC1 enzyme activity tes...


US Patent US10464911 (2019)

More data for this
Ligand-Target Pair
Cereblon/Histone deacetylase 1


(Homo sapiens (Human))
BDBM419623
PNG
(US10464911, Example 51)
Show SMILES C[C@H]1CN(C[C@@H](C)N1C(C)=O)S(=O)(=O)N(Cc1ccc(cc1)-c1nnc(o1)C(F)F)c1cccnc1
Show InChI InChI=1/C23H26F2N6O4S/c1-15-12-29(13-16(2)31(15)17(3)32)36(33,34)30(20-5-4-10-26-11-20)14-18-6-8-19(9-7-18)22-27-28-23(35-22)21(24)25/h4-11,15-16,21H,12-14H2,1-3H3/t15-,16+
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n/an/a 63n/an/an/an/an/an/a



Chong Kun Dang Pharmaceutical Corp.

US Patent


Assay Description
HDAC enzyme activity was measured using a HDAC Fluorimetric Drug Discovery Kit (BML-AK511, 516, Enzo Life Science). For the HDAC1 enzyme activity tes...


US Patent US10464911 (2019)

More data for this
Ligand-Target Pair
Cereblon/Histone deacetylase 1


(Homo sapiens (Human))
BDBM419569
PNG
(US10464911, Example 3)
Show SMILES Fc1cc(ccc1CN(c1ccccc1)S(=O)(=O)N1CCNCC1)-c1nnc(o1)C(F)(F)F
Show InChI InChI=1S/C20H19F4N5O3S/c21-17-12-14(18-26-27-19(32-18)20(22,23)24)6-7-15(17)13-29(16-4-2-1-3-5-16)33(30,31)28-10-8-25-9-11-28/h1-7,12,25H,8-11,13H2
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n/an/a 66n/an/an/an/an/an/a



Chong Kun Dang Pharmaceutical Corp.

US Patent


Assay Description
HDAC enzyme activity was measured using a HDAC Fluorimetric Drug Discovery Kit (BML-AK511, 516, Enzo Life Science). For the HDAC1 enzyme activity tes...


US Patent US10464911 (2019)

More data for this
Ligand-Target Pair
Cereblon/Histone deacetylase 1


(Homo sapiens (Human))
BDBM419604
PNG
(US10464911, Example 32)
Show SMILES CC(=O)N1CCN(CC1)S(=O)(=O)N(Cc1ccc(cc1F)-c1nnc(o1)C(F)(F)F)c1cccnc1
Show InChI InChI=1S/C21H20F4N6O4S/c1-14(32)29-7-9-30(10-8-29)36(33,34)31(17-3-2-6-26-12-17)13-16-5-4-15(11-18(16)22)19-27-28-20(35-19)21(23,24)25/h2-6,11-12H,7-10,13H2,1H3
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n/an/a 66n/an/an/an/an/an/a



Chong Kun Dang Pharmaceutical Corp.

US Patent


Assay Description
HDAC enzyme activity was measured using a HDAC Fluorimetric Drug Discovery Kit (BML-AK511, 516, Enzo Life Science). For the HDAC1 enzyme activity tes...


US Patent US10464911 (2019)

More data for this
Ligand-Target Pair
Cereblon/Histone deacetylase 1


(Homo sapiens (Human))
BDBM419601
PNG
(US10464911, Example 29)
Show SMILES CS(=O)(=O)N1CCN(CC1)S(=O)(=O)N(Cc1ccc(cc1F)-c1nnc(o1)C(F)F)c1cccnc1
Show InChI InChI=1S/C20H21F3N6O5S2/c1-35(30,31)27-7-9-28(10-8-27)36(32,33)29(16-3-2-6-24-12-16)13-15-5-4-14(11-17(15)21)19-25-26-20(34-19)18(22)23/h2-6,11-12,18H,7-10,13H2,1H3
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n/an/a 68n/an/an/an/an/an/a



Chong Kun Dang Pharmaceutical Corp.

US Patent


Assay Description
HDAC enzyme activity was measured using a HDAC Fluorimetric Drug Discovery Kit (BML-AK511, 516, Enzo Life Science). For the HDAC1 enzyme activity tes...


US Patent US10464911 (2019)

More data for this
Ligand-Target Pair
Cereblon/Histone deacetylase 1


(Homo sapiens (Human))
BDBM419616
PNG
(US10464911, Example 44)
Show SMILES C[C@H]1CN(C[C@@H](C)N1C)S(=O)(=O)N(Cc1ccc(cc1)-c1nnc(o1)C(F)F)c1ccccc1
Show InChI InChI=1/C23H27F2N5O3S/c1-16-13-29(14-17(2)28(16)3)34(31,32)30(20-7-5-4-6-8-20)15-18-9-11-19(12-10-18)22-26-27-23(33-22)21(24)25/h4-12,16-17,21H,13-15H2,1-3H3/t16-,17+
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n/an/a 69n/an/an/an/an/an/a



Chong Kun Dang Pharmaceutical Corp.

US Patent


Assay Description
HDAC enzyme activity was measured using a HDAC Fluorimetric Drug Discovery Kit (BML-AK511, 516, Enzo Life Science). For the HDAC1 enzyme activity tes...


US Patent US10464911 (2019)

More data for this
Ligand-Target Pair
Cereblon/Histone deacetylase 1


(Homo sapiens (Human))
BDBM419570
PNG
(US10464911, Example 4)
Show SMILES CC(=O)N1CCN(CC1)S(=O)(=O)N(Cc1ccc(cc1F)-c1nnc(o1)C(F)(F)F)c1ccccc1
Show InChI InChI=1S/C22H21F4N5O4S/c1-15(32)29-9-11-30(12-10-29)36(33,34)31(18-5-3-2-4-6-18)14-17-8-7-16(13-19(17)23)20-27-28-21(35-20)22(24,25)26/h2-8,13H,9-12,14H2,1H3
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n/an/a 71n/an/an/an/an/an/a



Chong Kun Dang Pharmaceutical Corp.

US Patent


Assay Description
HDAC enzyme activity was measured using a HDAC Fluorimetric Drug Discovery Kit (BML-AK511, 516, Enzo Life Science). For the HDAC1 enzyme activity tes...


US Patent US10464911 (2019)

More data for this
Ligand-Target Pair
Cereblon/Histone deacetylase 1


(Homo sapiens (Human))
BDBM419592
PNG
(US10464911, Example 22)
Show SMILES CN1CCN(CC1)S(=O)(=O)N(Cc1ccc(cc1F)-c1nnc(o1)C(F)(F)F)c1cccc(F)c1
Show InChI InChI=1S/C21H20F5N5O3S/c1-29-7-9-30(10-8-29)35(32,33)31(17-4-2-3-16(22)12-17)13-15-6-5-14(11-18(15)23)19-27-28-20(34-19)21(24,25)26/h2-6,11-12H,7-10,13H2,1H3
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n/an/a 73n/an/an/an/an/an/a



Chong Kun Dang Pharmaceutical Corp.

US Patent


Assay Description
HDAC enzyme activity was measured using a HDAC Fluorimetric Drug Discovery Kit (BML-AK511, 516, Enzo Life Science). For the HDAC1 enzyme activity tes...


US Patent US10464911 (2019)

More data for this
Ligand-Target Pair
Cereblon/Histone deacetylase 1


(Homo sapiens (Human))
BDBM419630
PNG
(US10464911, Example 57)
Show SMILES CC(C)N1CCN(CC1)S(=O)(=O)N(Cc1ccc(cc1)-c1nnc(o1)C(F)F)c1ccccc1
Show InChI InChI=1S/C23H27F2N5O3S/c1-17(2)28-12-14-29(15-13-28)34(31,32)30(20-6-4-3-5-7-20)16-18-8-10-19(11-9-18)22-26-27-23(33-22)21(24)25/h3-11,17,21H,12-16H2,1-2H3
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n/an/a 74n/an/an/an/an/an/a



Chong Kun Dang Pharmaceutical Corp.

US Patent


Assay Description
HDAC enzyme activity was measured using a HDAC Fluorimetric Drug Discovery Kit (BML-AK511, 516, Enzo Life Science). For the HDAC1 enzyme activity tes...


US Patent US10464911 (2019)

More data for this
Ligand-Target Pair
Cereblon/Histone deacetylase 1


(Homo sapiens (Human))
BDBM419576
PNG
(US10464911, Example 8)
Show SMILES CN1CCN(CC1)S(=O)(=O)N(Cc1ccc(cc1F)-c1nnc(o1)C(F)(F)F)c1ccccc1
Show InChI InChI=1S/C21H21F4N5O3S/c1-28-9-11-29(12-10-28)34(31,32)30(17-5-3-2-4-6-17)14-16-8-7-15(13-18(16)22)19-26-27-20(33-19)21(23,24)25/h2-8,13H,9-12,14H2,1H3
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n/an/a 75n/an/an/an/an/an/a



Chong Kun Dang Pharmaceutical Corp.

US Patent


Assay Description
HDAC enzyme activity was measured using a HDAC Fluorimetric Drug Discovery Kit (BML-AK511, 516, Enzo Life Science). For the HDAC1 enzyme activity tes...


US Patent US10464911 (2019)

More data for this
Ligand-Target Pair
Cereblon/Histone deacetylase 1


(Homo sapiens (Human))
BDBM419590
PNG
(US10464911, Example 20)
Show SMILES CS(=O)(=O)N1CCN(CC1)S(=O)(=O)N(Cc1ccc(cc1F)-c1nnc(o1)C(F)(F)F)c1cccc(F)c1
Show InChI InChI=1S/C21H20F5N5O5S2/c1-37(32,33)29-7-9-30(10-8-29)38(34,35)31(17-4-2-3-16(22)12-17)13-15-6-5-14(11-18(15)23)19-27-28-20(36-19)21(24,25)26/h2-6,11-12H,7-10,13H2,1H3
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n/an/a 76n/an/an/an/an/an/a



Chong Kun Dang Pharmaceutical Corp.

US Patent


Assay Description
HDAC enzyme activity was measured using a HDAC Fluorimetric Drug Discovery Kit (BML-AK511, 516, Enzo Life Science). For the HDAC1 enzyme activity tes...


US Patent US10464911 (2019)

More data for this
Ligand-Target Pair
Cereblon/Histone deacetylase 1


(Homo sapiens (Human))
BDBM419609
PNG
(US10464911, Example 37)
Show SMILES Fc1cc(ccc1CN(c1ccccc1)S(=O)(=O)N1CCN(CC1)C1COC1)-c1nnc(o1)C(F)(F)F
Show InChI InChI=1S/C23H23F4N5O4S/c24-20-12-16(21-28-29-22(36-21)23(25,26)27)6-7-17(20)13-32(18-4-2-1-3-5-18)37(33,34)31-10-8-30(9-11-31)19-14-35-15-19/h1-7,12,19H,8-11,13-15H2
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n/an/a 76n/an/an/an/an/an/a



Chong Kun Dang Pharmaceutical Corp.

US Patent


Assay Description
HDAC enzyme activity was measured using a HDAC Fluorimetric Drug Discovery Kit (BML-AK511, 516, Enzo Life Science). For the HDAC1 enzyme activity tes...


US Patent US10464911 (2019)

More data for this
Ligand-Target Pair
Cereblon/Histone deacetylase 1


(Homo sapiens (Human))
BDBM419610
PNG
(US10464911, Example 38)
Show SMILES FC(F)(F)c1nnc(o1)-c1ccc(CN(c2ccccc2)S(=O)(=O)N2CCN(CC2)C2COC2)nc1
Show InChI InChI=1S/C22H23F3N6O4S/c23-22(24,25)21-28-27-20(35-21)16-6-7-17(26-12-16)13-31(18-4-2-1-3-5-18)36(32,33)30-10-8-29(9-11-30)19-14-34-15-19/h1-7,12,19H,8-11,13-15H2
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n/an/a 79n/an/an/an/an/an/a



Chong Kun Dang Pharmaceutical Corp.

US Patent


Assay Description
HDAC enzyme activity was measured using a HDAC Fluorimetric Drug Discovery Kit (BML-AK511, 516, Enzo Life Science). For the HDAC1 enzyme activity tes...


US Patent US10464911 (2019)

More data for this
Ligand-Target Pair
Cereblon/Histone deacetylase 1


(Homo sapiens (Human))
BDBM419599
PNG
(US10464911, Example 27)
Show SMILES FC(F)c1nnc(o1)-c1ccc(CN(c2cccnc2)S(=O)(=O)N2CCNCC2)c(F)c1
Show InChI InChI=1S/C19H19F3N6O3S/c20-16-10-13(18-25-26-19(31-18)17(21)22)3-4-14(16)12-28(15-2-1-5-24-11-15)32(29,30)27-8-6-23-7-9-27/h1-5,10-11,17,23H,6-9,12H2
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n/an/a 81n/an/an/an/an/an/a



Chong Kun Dang Pharmaceutical Corp.

US Patent


Assay Description
HDAC enzyme activity was measured using a HDAC Fluorimetric Drug Discovery Kit (BML-AK511, 516, Enzo Life Science). For the HDAC1 enzyme activity tes...


US Patent US10464911 (2019)

More data for this
Ligand-Target Pair
Cereblon/Histone deacetylase 1


(Homo sapiens (Human))
BDBM419591
PNG
(US10464911, Example 21)
Show SMILES CC(=O)N1CCN(CC1)S(=O)(=O)N(Cc1ccc(cc1F)-c1nnc(o1)C(F)(F)F)c1cccc(F)c1
Show InChI InChI=1S/C22H20F5N5O4S/c1-14(33)30-7-9-31(10-8-30)37(34,35)32(18-4-2-3-17(23)12-18)13-16-6-5-15(11-19(16)24)20-28-29-21(36-20)22(25,26)27/h2-6,11-12H,7-10,13H2,1H3
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n/an/a 84n/an/an/an/an/an/a



Chong Kun Dang Pharmaceutical Corp.

US Patent


Assay Description
HDAC enzyme activity was measured using a HDAC Fluorimetric Drug Discovery Kit (BML-AK511, 516, Enzo Life Science). For the HDAC1 enzyme activity tes...


US Patent US10464911 (2019)

More data for this
Ligand-Target Pair
Cereblon/Histone deacetylase 1


(Homo sapiens (Human))
BDBM419577
PNG
(US10464911, Example 9)
Show SMILES CCN1CCN(CC1)S(=O)(=O)N(Cc1ccc(cc1F)-c1nnc(o1)C(F)(F)F)c1ccccc1
Show InChI InChI=1S/C22H23F4N5O3S/c1-2-29-10-12-30(13-11-29)35(32,33)31(18-6-4-3-5-7-18)15-17-9-8-16(14-19(17)23)20-27-28-21(34-20)22(24,25)26/h3-9,14H,2,10-13,15H2,1H3
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n/an/a 86n/an/an/an/an/an/a



Chong Kun Dang Pharmaceutical Corp.

US Patent


Assay Description
HDAC enzyme activity was measured using a HDAC Fluorimetric Drug Discovery Kit (BML-AK511, 516, Enzo Life Science). For the HDAC1 enzyme activity tes...


US Patent US10464911 (2019)

More data for this
Ligand-Target Pair
Cereblon/Histone deacetylase 1


(Homo sapiens (Human))
BDBM419632
PNG
(US10464911, Example 59)
Show SMILES CN(CCN1CCN(C)CC1)S(=O)(=O)N(Cc1ccc(cc1)-c1nnc(o1)C(F)F)c1ccccc1
Show InChI InChI=1S/C24H30F2N6O3S/c1-29-12-15-31(16-13-29)17-14-30(2)36(33,34)32(21-6-4-3-5-7-21)18-19-8-10-20(11-9-19)23-27-28-24(35-23)22(25)26/h3-11,22H,12-18H2,1-2H3
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n/an/a 93n/an/an/an/an/an/a



Chong Kun Dang Pharmaceutical Corp.

US Patent


Assay Description
HDAC enzyme activity was measured using a HDAC Fluorimetric Drug Discovery Kit (BML-AK511, 516, Enzo Life Science). For the HDAC1 enzyme activity tes...


US Patent US10464911 (2019)

More data for this
Ligand-Target Pair
Cereblon/Histone deacetylase 1


(Homo sapiens (Human))
BDBM419637
PNG
(US10464911, Example 63)
Show SMILES FC(F)c1nnc(o1)-c1ccc(CN(c2ccccc2)S(=O)(=O)N2CCC3(CNC3)CC2)cc1
Show InChI InChI=1S/C23H25F2N5O3S/c24-20(25)22-28-27-21(33-22)18-8-6-17(7-9-18)14-30(19-4-2-1-3-5-19)34(31,32)29-12-10-23(11-13-29)15-26-16-23/h1-9,20,26H,10-16H2
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n/an/a 96n/an/an/an/an/an/a



Chong Kun Dang Pharmaceutical Corp.

US Patent


Assay Description
HDAC enzyme activity was measured using a HDAC Fluorimetric Drug Discovery Kit (BML-AK511, 516, Enzo Life Science). For the HDAC1 enzyme activity tes...


US Patent US10464911 (2019)

More data for this
Ligand-Target Pair
Cereblon/Histone deacetylase 1


(Homo sapiens (Human))
BDBM419613
PNG
(US10464911, Example 41)
Show SMILES CCN1[C@@H](C)CN(C[C@H]1C)S(=O)(=O)N(Cc1ccc(cc1)-c1nnc(o1)C(F)F)c1ccccc1
Show InChI InChI=1/C24H29F2N5O3S/c1-4-30-17(2)14-29(15-18(30)3)35(32,33)31(21-8-6-5-7-9-21)16-19-10-12-20(13-11-19)23-27-28-24(34-23)22(25)26/h5-13,17-18,22H,4,14-16H2,1-3H3/t17-,18+
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n/an/a 105n/an/an/an/an/an/a



Chong Kun Dang Pharmaceutical Corp.

US Patent


Assay Description
HDAC enzyme activity was measured using a HDAC Fluorimetric Drug Discovery Kit (BML-AK511, 516, Enzo Life Science). For the HDAC1 enzyme activity tes...


US Patent US10464911 (2019)

More data for this
Ligand-Target Pair
Cereblon/Histone deacetylase 1


(Homo sapiens (Human))
BDBM419578
PNG
(US10464911, Example 10)
Show SMILES CC(C)N1CCN(CC1)S(=O)(=O)N(Cc1ccc(cc1F)-c1nnc(o1)C(F)(F)F)c1ccccc1
Show InChI InChI=1S/C23H25F4N5O3S/c1-16(2)30-10-12-31(13-11-30)36(33,34)32(19-6-4-3-5-7-19)15-18-9-8-17(14-20(18)24)21-28-29-22(35-21)23(25,26)27/h3-9,14,16H,10-13,15H2,1-2H3
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n/an/a 116n/an/an/an/an/an/a



Chong Kun Dang Pharmaceutical Corp.

US Patent


Assay Description
HDAC enzyme activity was measured using a HDAC Fluorimetric Drug Discovery Kit (BML-AK511, 516, Enzo Life Science). For the HDAC1 enzyme activity tes...


US Patent US10464911 (2019)

More data for this
Ligand-Target Pair
Cereblon/Histone deacetylase 1


(Homo sapiens (Human))
BDBM419639
PNG
(US10464911, Example 65)
Show SMILES FC(F)c1nnc(o1)-c1ccc(CN(c2ccccc2)S(=O)(=O)N2CCC3(CN(C3)C3CCC3)CC2)cc1
Show InChI InChI=1S/C27H31F2N5O3S/c28-24(29)26-31-30-25(37-26)21-11-9-20(10-12-21)17-34(23-5-2-1-3-6-23)38(35,36)33-15-13-27(14-16-33)18-32(19-27)22-7-4-8-22/h1-3,5-6,9-12,22,24H,4,7-8,13-19H2
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n/an/a 122n/an/an/an/an/an/a



Chong Kun Dang Pharmaceutical Corp.

US Patent


Assay Description
HDAC enzyme activity was measured using a HDAC Fluorimetric Drug Discovery Kit (BML-AK511, 516, Enzo Life Science). For the HDAC1 enzyme activity tes...


US Patent US10464911 (2019)

More data for this
Ligand-Target Pair
Cereblon/Histone deacetylase 1


(Homo sapiens (Human))
BDBM419575
PNG
(US10464911, Example 7)
Show SMILES CS(=O)(=O)N1CCN(CC1)S(=O)(=O)N(Cc1ccc(cc1F)-c1nnc(o1)C(F)(F)F)c1ccccc1
Show InChI InChI=1S/C21H21F4N5O5S2/c1-36(31,32)28-9-11-29(12-10-28)37(33,34)30(17-5-3-2-4-6-17)14-16-8-7-15(13-18(16)22)19-26-27-20(35-19)21(23,24)25/h2-8,13H,9-12,14H2,1H3
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n/an/a 124n/an/an/an/an/an/a



Chong Kun Dang Pharmaceutical Corp.

US Patent


Assay Description
HDAC enzyme activity was measured using a HDAC Fluorimetric Drug Discovery Kit (BML-AK511, 516, Enzo Life Science). For the HDAC1 enzyme activity tes...


US Patent US10464911 (2019)

More data for this
Ligand-Target Pair
Cereblon/Histone deacetylase 1


(Homo sapiens (Human))
BDBM419617
PNG
(US10464911, Example 45)
Show SMILES C[C@H]1CN(C[C@@H](C)N1C(=O)[H]C(F)F)S(=O)(=O)N(Cc1ccc(cc1)-c1nnc(o1)C(F)F)c1ccccc1
Show InChI InChI=1/C24H26F4N5O4S/c1-15-12-31(13-16(2)33(15)24(34)39-23(27)28)38(35,36)32(19-6-4-3-5-7-19)14-17-8-10-18(11-9-17)21-29-30-22(37-21)20(25)26/h3-11,15-16,20,23H,12-14H2,1-2H3/t15-,16+
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n/an/a 130n/an/an/an/an/an/a



Chong Kun Dang Pharmaceutical Corp.

US Patent


Assay Description
HDAC enzyme activity was measured using a HDAC Fluorimetric Drug Discovery Kit (BML-AK511, 516, Enzo Life Science). For the HDAC1 enzyme activity tes...


US Patent US10464911 (2019)

More data for this
Ligand-Target Pair
Cereblon/Histone deacetylase 1


(Homo sapiens (Human))
BDBM419572
PNG
(US10464911, Example 5)
Show SMILES CCC(=O)N1CCN(CC1)S(=O)(=O)N(Cc1ccc(cc1F)-c1nnc(o1)C(F)(F)F)c1ccccc1
Show InChI InChI=1S/C23H23F4N5O4S/c1-2-20(33)30-10-12-31(13-11-30)37(34,35)32(18-6-4-3-5-7-18)15-17-9-8-16(14-19(17)24)21-28-29-22(36-21)23(25,26)27/h3-9,14H,2,10-13,15H2,1H3
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n/an/a 133n/an/an/an/an/an/a



Chong Kun Dang Pharmaceutical Corp.

US Patent


Assay Description
HDAC enzyme activity was measured using a HDAC Fluorimetric Drug Discovery Kit (BML-AK511, 516, Enzo Life Science). For the HDAC1 enzyme activity tes...


US Patent US10464911 (2019)

More data for this
Ligand-Target Pair
Cereblon/Histone deacetylase 1


(Homo sapiens (Human))
BDBM419631
PNG
(US10464911, Example 58)
Show SMILES FC(F)c1nnc(o1)-c1ccc(CN(c2ccccc2)S(=O)(=O)N2CCN(CC2)C2CCC2)cc1
Show InChI InChI=1S/C24H27F2N5O3S/c25-22(26)24-28-27-23(34-24)19-11-9-18(10-12-19)17-31(21-5-2-1-3-6-21)35(32,33)30-15-13-29(14-16-30)20-7-4-8-20/h1-3,5-6,9-12,20,22H,4,7-8,13-17H2
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n/an/a 133n/an/an/an/an/an/a



Chong Kun Dang Pharmaceutical Corp.

US Patent


Assay Description
HDAC enzyme activity was measured using a HDAC Fluorimetric Drug Discovery Kit (BML-AK511, 516, Enzo Life Science). For the HDAC1 enzyme activity tes...


US Patent US10464911 (2019)

More data for this
Ligand-Target Pair
Cereblon/Histone deacetylase 1


(Homo sapiens (Human))
BDBM419567
PNG
(US10464911, Example 1)
Show SMILES Fc1ccc(cc1)N(Cc1ccc(cc1)-c1nnc(o1)C(F)(F)F)S(=O)(=O)N1CCOCC1
Show InChI InChI=1S/C20H18F4N4O4S/c21-16-5-7-17(8-6-16)28(33(29,30)27-9-11-31-12-10-27)13-14-1-3-15(4-2-14)18-25-26-19(32-18)20(22,23)24/h1-8H,9-13H2
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n/an/a 136n/an/an/an/an/an/a



Chong Kun Dang Pharmaceutical Corp.

US Patent


Assay Description
HDAC enzyme activity was measured using a HDAC Fluorimetric Drug Discovery Kit (BML-AK511, 516, Enzo Life Science). For the HDAC1 enzyme activity tes...


US Patent US10464911 (2019)

More data for this
Ligand-Target Pair
Cereblon/Histone deacetylase 1


(Homo sapiens (Human))
BDBM419574
PNG
(US10464911, Example 6)
Show SMILES CC(C)C(=O)N1CCN(CC1)S(=O)(=O)N(Cc1ccc(cc1F)-c1nnc(o1)C(F)(F)F)c1ccccc1
Show InChI InChI=1S/C24H25F4N5O4S/c1-16(2)22(34)31-10-12-32(13-11-31)38(35,36)33(19-6-4-3-5-7-19)15-18-9-8-17(14-20(18)25)21-29-30-23(37-21)24(26,27)28/h3-9,14,16H,10-13,15H2,1-2H3
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n/an/a 157n/an/an/an/an/an/a



Chong Kun Dang Pharmaceutical Corp.

US Patent


Assay Description
HDAC enzyme activity was measured using a HDAC Fluorimetric Drug Discovery Kit (BML-AK511, 516, Enzo Life Science). For the HDAC1 enzyme activity tes...


US Patent US10464911 (2019)

More data for this
Ligand-Target Pair
Cereblon/Histone deacetylase 1


(Homo sapiens (Human))
BDBM419636
PNG
(US10464911, Example 62)
Show SMILES CN(CCN1CCN(CC1)S(C)(=O)=O)S(=O)(=O)N(Cc1ccc(cc1)-c1nnc(o1)C(F)F)c1ccccc1
Show InChI InChI=1S/C24H30F2N6O5S2/c1-29(12-13-30-14-16-31(17-15-30)38(2,33)34)39(35,36)32(21-6-4-3-5-7-21)18-19-8-10-20(11-9-19)23-27-28-24(37-23)22(25)26/h3-11,22H,12-18H2,1-2H3
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n/an/a 162n/an/an/an/an/an/a



Chong Kun Dang Pharmaceutical Corp.

US Patent


Assay Description
HDAC enzyme activity was measured using a HDAC Fluorimetric Drug Discovery Kit (BML-AK511, 516, Enzo Life Science). For the HDAC1 enzyme activity tes...


US Patent US10464911 (2019)

More data for this
Ligand-Target Pair
Cereblon/Histone deacetylase 1


(Homo sapiens (Human))
BDBM419638
PNG
(US10464911, Example 64)
Show SMILES FC(F)c1nnc(o1)-c1ccc(CN(c2ccccc2)S(=O)(=O)N2CCC3(CN(C3)C3COC3)CC2)cc1
Show InChI InChI=1S/C26H29F2N5O4S/c27-23(28)25-30-29-24(37-25)20-8-6-19(7-9-20)14-33(21-4-2-1-3-5-21)38(34,35)32-12-10-26(11-13-32)17-31(18-26)22-15-36-16-22/h1-9,22-23H,10-18H2
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n/an/a 178n/an/an/an/an/an/a



Chong Kun Dang Pharmaceutical Corp.

US Patent


Assay Description
HDAC enzyme activity was measured using a HDAC Fluorimetric Drug Discovery Kit (BML-AK511, 516, Enzo Life Science). For the HDAC1 enzyme activity tes...


US Patent US10464911 (2019)

More data for this
Ligand-Target Pair
Cereblon/Histone deacetylase 1


(Homo sapiens (Human))
BDBM419633
PNG
(US10464911, Example 60)
Show SMILES CN(CCN1CCN(CC1)C1COC1)S(=O)(=O)N(Cc1ccc(cc1)-c1nnc(o1)C(F)F)c1ccccc1
Show InChI InChI=1S/C26H32F2N6O4S/c1-31(11-12-32-13-15-33(16-14-32)23-18-37-19-23)39(35,36)34(22-5-3-2-4-6-22)17-20-7-9-21(10-8-20)25-29-30-26(38-25)24(27)28/h2-10,23-24H,11-19H2,1H3
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n/an/a 233n/an/an/an/an/an/a



Chong Kun Dang Pharmaceutical Corp.

US Patent


Assay Description
HDAC enzyme activity was measured using a HDAC Fluorimetric Drug Discovery Kit (BML-AK511, 516, Enzo Life Science). For the HDAC1 enzyme activity tes...


US Patent US10464911 (2019)

More data for this
Ligand-Target Pair
Cereblon/Histone deacetylase 1


(Homo sapiens (Human))
BDBM419619
PNG
(US10464911, Example 47)
Show SMILES FC(F)c1nnc(o1)-c1ccc(CN(c2ccc(F)c(Cl)c2)S(=O)(=O)N2CCN(CC2)C2CCC2)cc1
Show InChI InChI=1S/C24H25ClF3N5O3S/c25-20-14-19(8-9-21(20)26)33(37(34,35)32-12-10-31(11-13-32)18-2-1-3-18)15-16-4-6-17(7-5-16)23-29-30-24(36-23)22(27)28/h4-9,14,18,22H,1-3,10-13,15H2
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n/an/a 237n/an/an/an/an/an/a



Chong Kun Dang Pharmaceutical Corp.

US Patent


Assay Description
HDAC enzyme activity was measured using a HDAC Fluorimetric Drug Discovery Kit (BML-AK511, 516, Enzo Life Science). For the HDAC1 enzyme activity tes...


US Patent US10464911 (2019)

More data for this
Ligand-Target Pair
Cereblon/Histone deacetylase 1


(Homo sapiens (Human))
BDBM419615
PNG
(US10464911, Example 43)
Show SMILES CCCN1[C@@H](C)CN(C[C@H]1C)S(=O)(=O)N(Cc1ccc(cc1)-c1nnc(o1)C(F)F)c1ccccc1
Show InChI InChI=1/C25H31F2N5O3S/c1-4-14-31-18(2)15-30(16-19(31)3)36(33,34)32(22-8-6-5-7-9-22)17-20-10-12-21(13-11-20)24-28-29-25(35-24)23(26)27/h5-13,18-19,23H,4,14-17H2,1-3H3/t18-,19+
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n/an/a 348n/an/an/an/an/an/a



Chong Kun Dang Pharmaceutical Corp.

US Patent


Assay Description
HDAC enzyme activity was measured using a HDAC Fluorimetric Drug Discovery Kit (BML-AK511, 516, Enzo Life Science). For the HDAC1 enzyme activity tes...


US Patent US10464911 (2019)

More data for this
Ligand-Target Pair
Cereblon/Histone deacetylase 1


(Homo sapiens (Human))
BDBM419618
PNG
(US10464911, Example 46)
Show SMILES CC(C)N1CCN(CC1)S(=O)(=O)N(Cc1ccc(cc1)-c1nnc(o1)C(F)F)c1ccc(F)c(Cl)c1
Show InChI InChI=1S/C23H25ClF3N5O3S/c1-15(2)30-9-11-31(12-10-30)36(33,34)32(18-7-8-20(25)19(24)13-18)14-16-3-5-17(6-4-16)22-28-29-23(35-22)21(26)27/h3-8,13,15,21H,9-12,14H2,1-2H3
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n/an/a 481n/an/an/an/an/an/a



Chong Kun Dang Pharmaceutical Corp.

US Patent


Assay Description
HDAC enzyme activity was measured using a HDAC Fluorimetric Drug Discovery Kit (BML-AK511, 516, Enzo Life Science). For the HDAC1 enzyme activity tes...


US Patent US10464911 (2019)

More data for this
Ligand-Target Pair
Cereblon/Histone deacetylase 1


(Homo sapiens (Human))
BDBM419634
PNG
(US10464911, Example 61)
Show SMILES CN(CCN1CCN(CC1)C(C)=O)S(=O)(=O)N(Cc1ccc(cc1)-c1nnc(o1)C(F)F)c1ccccc1
Show InChI InChI=1S/C25H30F2N6O4S/c1-19(34)32-16-14-31(15-17-32)13-12-30(2)38(35,36)33(22-6-4-3-5-7-22)18-20-8-10-21(11-9-20)24-28-29-25(37-24)23(26)27/h3-11,23H,12-18H2,1-2H3
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n/an/a 705n/an/an/an/an/an/a



Chong Kun Dang Pharmaceutical Corp.

US Patent


Assay Description
HDAC enzyme activity was measured using a HDAC Fluorimetric Drug Discovery Kit (BML-AK511, 516, Enzo Life Science). For the HDAC1 enzyme activity tes...


US Patent US10464911 (2019)

More data for this
Ligand-Target Pair
Cereblon/Histone deacetylase 6


(Homo sapiens (Human))
BDBM419589
PNG
(US10464911, Example 19)
Show SMILES Fc1cccc(c1)N(Cc1ccc(cc1F)-c1nnc(o1)C(F)(F)F)S(=O)(=O)N1CCNCC1
Show InChI InChI=1S/C20H18F5N5O3S/c21-15-2-1-3-16(11-15)30(34(31,32)29-8-6-26-7-9-29)12-14-5-4-13(10-17(14)22)18-27-28-19(33-18)20(23,24)25/h1-5,10-11,26H,6-9,12H2
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n/an/a 4.15E+4n/an/an/an/an/an/a



Chong Kun Dang Pharmaceutical Corp.

US Patent


Assay Description
HDAC enzyme activity was measured using a HDAC Fluorimetric Drug Discovery Kit (BML-AK511, 516, Enzo Life Science). For the HDAC1 enzyme activity tes...


US Patent US10464911 (2019)

More data for this
Ligand-Target Pair
Cereblon/Histone deacetylase 6


(Homo sapiens (Human))
BDBM419610
PNG
(US10464911, Example 38)
Show SMILES FC(F)(F)c1nnc(o1)-c1ccc(CN(c2ccccc2)S(=O)(=O)N2CCN(CC2)C2COC2)nc1
Show InChI InChI=1S/C22H23F3N6O4S/c23-22(24,25)21-28-27-20(35-21)16-6-7-17(26-12-16)13-31(18-4-2-1-3-5-18)36(32,33)30-10-8-29(9-11-30)19-14-34-15-19/h1-7,12,19H,8-11,13-15H2
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n/an/a 4.16E+4n/an/an/an/an/an/a



Chong Kun Dang Pharmaceutical Corp.

US Patent


Assay Description
HDAC enzyme activity was measured using a HDAC Fluorimetric Drug Discovery Kit (BML-AK511, 516, Enzo Life Science). For the HDAC1 enzyme activity tes...


US Patent US10464911 (2019)

More data for this
Ligand-Target Pair
Cereblon/Histone deacetylase 6


(Homo sapiens (Human))
BDBM419609
PNG
(US10464911, Example 37)
Show SMILES Fc1cc(ccc1CN(c1ccccc1)S(=O)(=O)N1CCN(CC1)C1COC1)-c1nnc(o1)C(F)(F)F
Show InChI InChI=1S/C23H23F4N5O4S/c24-20-12-16(21-28-29-22(36-21)23(25,26)27)6-7-17(20)13-32(18-4-2-1-3-5-18)37(33,34)31-10-8-30(9-11-31)19-14-35-15-19/h1-7,12,19H,8-11,13-15H2
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n/an/a 4.77E+4n/an/an/an/an/an/a



Chong Kun Dang Pharmaceutical Corp.

US Patent


Assay Description
HDAC enzyme activity was measured using a HDAC Fluorimetric Drug Discovery Kit (BML-AK511, 516, Enzo Life Science). For the HDAC1 enzyme activity tes...


US Patent US10464911 (2019)

More data for this
Ligand-Target Pair
Cereblon/Histone deacetylase 6


(Homo sapiens (Human))
BDBM419608
PNG
(US10464911, Example 36)
Show SMILES FC(F)c1nnc(o1)-c1ccc(CN(c2ccc(F)c(Cl)c2)S(=O)(=O)N2CCS(=O)(=O)CC2)nc1
Show InChI InChI=1S/C19H17ClF3N5O5S2/c20-15-9-14(3-4-16(15)21)28(35(31,32)27-5-7-34(29,30)8-6-27)11-13-2-1-12(10-24-13)18-25-26-19(33-18)17(22)23/h1-4,9-10,17H,5-8,11H2
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n/an/a 4.92E+4n/an/an/an/an/an/a



Chong Kun Dang Pharmaceutical Corp.

US Patent


Assay Description
HDAC enzyme activity was measured using a HDAC Fluorimetric Drug Discovery Kit (BML-AK511, 516, Enzo Life Science). For the HDAC1 enzyme activity tes...


US Patent US10464911 (2019)

More data for this
Ligand-Target Pair
Cereblon/Histone deacetylase 6


(Homo sapiens (Human))
BDBM419632
PNG
(US10464911, Example 59)
Show SMILES CN(CCN1CCN(C)CC1)S(=O)(=O)N(Cc1ccc(cc1)-c1nnc(o1)C(F)F)c1ccccc1
Show InChI InChI=1S/C24H30F2N6O3S/c1-29-12-15-31(16-13-29)17-14-30(2)36(33,34)32(21-6-4-3-5-7-21)18-19-8-10-20(11-9-19)23-27-28-24(35-23)22(25)26/h3-11,22H,12-18H2,1-2H3
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n/an/a 5.02E+4n/an/an/an/an/an/a



Chong Kun Dang Pharmaceutical Corp.

US Patent


Assay Description
HDAC enzyme activity was measured using a HDAC Fluorimetric Drug Discovery Kit (BML-AK511, 516, Enzo Life Science). For the HDAC1 enzyme activity tes...


US Patent US10464911 (2019)

More data for this
Ligand-Target Pair
Cereblon/Histone deacetylase 6


(Homo sapiens (Human))
BDBM419620
PNG
(US10464911, Example 48)
Show SMILES FC(F)c1nnc(o1)-c1ccc(CN(c2ccc(F)c(Cl)c2)S(=O)(=O)N2CCN(CC2)C2COC2)cc1
Show InChI InChI=1S/C23H23ClF3N5O4S/c24-19-11-17(5-6-20(19)25)32(37(33,34)31-9-7-30(8-10-31)18-13-35-14-18)12-15-1-3-16(4-2-15)22-28-29-23(36-22)21(26)27/h1-6,11,18,21H,7-10,12-14H2
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n/an/a 5.24E+4n/an/an/an/an/an/a



Chong Kun Dang Pharmaceutical Corp.

US Patent


Assay Description
HDAC enzyme activity was measured using a HDAC Fluorimetric Drug Discovery Kit (BML-AK511, 516, Enzo Life Science). For the HDAC1 enzyme activity tes...


US Patent US10464911 (2019)

More data for this
Ligand-Target Pair
Cereblon/Histone deacetylase 6


(Homo sapiens (Human))
BDBM419625
PNG
(US10464911, Example 53)
Show SMILES C[C@H]1CN(C[C@@H](C)N1C)S(=O)(=O)N(Cc1ccc(cc1)-c1nnc(o1)C(F)F)c1cccnc1
Show InChI InChI=1/C22H26F2N6O3S/c1-15-12-29(13-16(2)28(15)3)34(31,32)30(19-5-4-10-25-11-19)14-17-6-8-18(9-7-17)21-26-27-22(33-21)20(23)24/h4-11,15-16,20H,12-14H2,1-3H3/t15-,16+
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n/an/a 5.53E+4n/an/an/an/an/an/a



Chong Kun Dang Pharmaceutical Corp.

US Patent


Assay Description
HDAC enzyme activity was measured using a HDAC Fluorimetric Drug Discovery Kit (BML-AK511, 516, Enzo Life Science). For the HDAC1 enzyme activity tes...


US Patent US10464911 (2019)

More data for this
Ligand-Target Pair
Cereblon/Histone deacetylase 6


(Homo sapiens (Human))
BDBM419621
PNG
(US10464911, Example 49)
Show SMILES CN1CCN(CC1)S(=O)(=O)N(Cc1ccc(cc1)-c1nnc(o1)C(F)F)c1ccc(F)c(Cl)c1
Show InChI InChI=1S/C21H21ClF3N5O3S/c1-28-8-10-29(11-9-28)34(31,32)30(16-6-7-18(23)17(22)12-16)13-14-2-4-15(5-3-14)20-26-27-21(33-20)19(24)25/h2-7,12,19H,8-11,13H2,1H3
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n/an/a 7.15E+4n/an/an/an/an/an/a



Chong Kun Dang Pharmaceutical Corp.

US Patent


Assay Description
HDAC enzyme activity was measured using a HDAC Fluorimetric Drug Discovery Kit (BML-AK511, 516, Enzo Life Science). For the HDAC1 enzyme activity tes...


US Patent US10464911 (2019)

More data for this
Ligand-Target Pair
Cereblon/Histone deacetylase 6


(Homo sapiens (Human))
BDBM419622
PNG
(US10464911, Example 50)
Show SMILES C[C@H]1CN(C[C@@H](C)N1C(C)=O)S(=O)(=O)N(Cc1ccc(cn1)-c1nnc(o1)C(F)F)c1ccccc1
Show InChI InChI=1/C23H26F2N6O4S/c1-15-12-29(13-16(2)31(15)17(3)32)36(33,34)30(20-7-5-4-6-8-20)14-19-10-9-18(11-26-19)22-27-28-23(35-22)21(24)25/h4-11,15-16,21H,12-14H2,1-3H3/t15-,16+
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n/an/a 7.24E+4n/an/an/an/an/an/a



Chong Kun Dang Pharmaceutical Corp.

US Patent


Assay Description
HDAC enzyme activity was measured using a HDAC Fluorimetric Drug Discovery Kit (BML-AK511, 516, Enzo Life Science). For the HDAC1 enzyme activity tes...


US Patent US10464911 (2019)

More data for this
Ligand-Target Pair
Cereblon/Histone deacetylase 6


(Homo sapiens (Human))
BDBM419569
PNG
(US10464911, Example 3)
Show SMILES Fc1cc(ccc1CN(c1ccccc1)S(=O)(=O)N1CCNCC1)-c1nnc(o1)C(F)(F)F
Show InChI InChI=1S/C20H19F4N5O3S/c21-17-12-14(18-26-27-19(32-18)20(22,23)24)6-7-15(17)13-29(16-4-2-1-3-5-16)33(30,31)28-10-8-25-9-11-28/h1-7,12,25H,8-11,13H2
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n/an/a 7.60E+4n/an/an/an/an/an/a



Chong Kun Dang Pharmaceutical Corp.

US Patent


Assay Description
HDAC enzyme activity was measured using a HDAC Fluorimetric Drug Discovery Kit (BML-AK511, 516, Enzo Life Science). For the HDAC1 enzyme activity tes...


US Patent US10464911 (2019)

More data for this
Ligand-Target Pair
Cereblon/Histone deacetylase 6


(Homo sapiens (Human))
BDBM419623
PNG
(US10464911, Example 51)
Show SMILES C[C@H]1CN(C[C@@H](C)N1C(C)=O)S(=O)(=O)N(Cc1ccc(cc1)-c1nnc(o1)C(F)F)c1cccnc1
Show InChI InChI=1/C23H26F2N6O4S/c1-15-12-29(13-16(2)31(15)17(3)32)36(33,34)30(20-5-4-10-26-11-20)14-18-6-8-19(9-7-18)22-27-28-23(35-22)21(24)25/h4-11,15-16,21H,12-14H2,1-3H3/t15-,16+
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n/an/a 7.65E+4n/an/an/an/an/an/a



Chong Kun Dang Pharmaceutical Corp.

US Patent


Assay Description
HDAC enzyme activity was measured using a HDAC Fluorimetric Drug Discovery Kit (BML-AK511, 516, Enzo Life Science). For the HDAC1 enzyme activity tes...


US Patent US10464911 (2019)

More data for this
Ligand-Target Pair
Cereblon/Histone deacetylase 6


(Homo sapiens (Human))
BDBM419624
PNG
(US10464911, Example 52)
Show SMILES CCN1[C@@H](C)CN(C[C@H]1C)S(=O)(=O)N(Cc1ccc(cn1)-c1nnc(o1)C(F)F)c1ccccc1
Show InChI InChI=1/C23H28F2N6O3S/c1-4-30-16(2)13-29(14-17(30)3)35(32,33)31(20-8-6-5-7-9-20)15-19-11-10-18(12-26-19)22-27-28-23(34-22)21(24)25/h5-12,16-17,21H,4,13-15H2,1-3H3/t16-,17+
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n/an/a 1.16E+5n/an/an/an/an/an/a



Chong Kun Dang Pharmaceutical Corp.

US Patent


Assay Description
HDAC enzyme activity was measured using a HDAC Fluorimetric Drug Discovery Kit (BML-AK511, 516, Enzo Life Science). For the HDAC1 enzyme activity tes...


US Patent US10464911 (2019)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%