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Patent code US10464918

Compile Data Set for Download or QSAR
Found 11 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Somatostatin receptor type 2


(Homo sapiens (Human))
BDBM419661
PNG
(US10464918, Compound 1-5)
Show SMILES Nc1c(ccnc1-c1ccc2ncc(-c3cc(F)cc(Cl)c3)c(N3CC[C@@H]4NCCO[C@H]4C3)c2c1)C#N
Show InChI InChI=1S/C28H24ClFN6O/c29-19-9-18(10-20(30)12-19)22-14-35-23-2-1-16(27-26(32)17(13-31)3-5-34-27)11-21(23)28(22)36-7-4-24-25(15-36)37-8-6-33-24/h1-3,5,9-12,14,24-25,33H,4,6-8,15,32H2/t24-,25-/m0/s1
KEGG

UniProtKB/SwissProt

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GoogleScholar
UniChem
US Patent
n/an/an/an/a<10n/an/an/an/a



CRINETICS PHARMACEUTICALS, INC.

US Patent


Assay Description
Four days prior to the assay, 5,000 Chinese hamster ovary cells (CHO-K1, ATCC #CCL-61) stably expressing the human SSTR2 are plated in each well of a...


US Patent US10464918 (2019)

More data for this
Ligand-Target Pair
Somatostatin receptor type 2


(Homo sapiens (Human))
BDBM419665
PNG
(US10464918, Compound 1-9)
Show SMILES Cc1cc(F)cc(c1)-c1cnc2ccc(c(F)c2c1N1CCC(N)CC1)-c1cccc(C#N)c1O
Show InChI InChI=1S/C28H24F2N4O/c1-16-11-18(13-19(29)12-16)23-15-33-24-6-5-21(22-4-2-3-17(14-31)28(22)35)26(30)25(24)27(23)34-9-7-20(32)8-10-34/h2-6,11-13,15,20,35H,7-10,32H2,1H3
KEGG

UniProtKB/SwissProt

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GoogleScholar
UniChem
US Patent
n/an/an/an/a<10n/an/an/an/a



CRINETICS PHARMACEUTICALS, INC.

US Patent


Assay Description
Four days prior to the assay, 5,000 Chinese hamster ovary cells (CHO-K1, ATCC #CCL-61) stably expressing the human SSTR2 are plated in each well of a...


US Patent US10464918 (2019)

More data for this
Ligand-Target Pair
Somatostatin receptor type 2


(Homo sapiens (Human))
BDBM419657
PNG
(US10464918, Compound 1-1)
Show SMILES O\N=C\c1cccc(c1O)-c1ccc2ncc(-c3cc(F)cc(F)c3)c(N3CC[C@@H]4NCCO[C@H]4C3)c2c1
Show InChI InChI=1S/C29H26F2N4O3/c30-20-10-19(11-21(31)13-20)24-15-33-25-5-4-17(22-3-1-2-18(14-34-37)29(22)36)12-23(25)28(24)35-8-6-26-27(16-35)38-9-7-32-26/h1-5,10-15,26-27,32,36-37H,6-9,16H2/b34-14+/t26-,27-/m0/s1
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
KEGG
UniChem
US Patent
n/an/an/an/a<10n/an/an/an/a



CRINETICS PHARMACEUTICALS, INC.

US Patent


Assay Description
Four days prior to the assay, 5,000 Chinese hamster ovary cells (CHO-K1, ATCC #CCL-61) stably expressing the human SSTR2 are plated in each well of a...


US Patent US10464918 (2019)

More data for this
Ligand-Target Pair
Somatostatin receptor type 2


(Homo sapiens (Human))
BDBM419663
PNG
(US10464918, Compound 1-7)
Show SMILES Nc1c(ccnc1-c1ccc2ncc(-c3cccc(F)c3)c(N3CC[C@@H]4NCCO[C@H]4C3)c2c1)C#N
Show InChI InChI=1S/C28H25FN6O/c29-20-3-1-2-17(12-20)22-15-34-23-5-4-18(27-26(31)19(14-30)6-8-33-27)13-21(23)28(22)35-10-7-24-25(16-35)36-11-9-32-24/h1-6,8,12-13,15,24-25,32H,7,9-11,16,31H2/t24-,25-/m0/s1
KEGG

UniProtKB/SwissProt

DrugBank
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UniChem
US Patent
n/an/an/an/a<10n/an/an/an/a



CRINETICS PHARMACEUTICALS, INC.

US Patent


Assay Description
Four days prior to the assay, 5,000 Chinese hamster ovary cells (CHO-K1, ATCC #CCL-61) stably expressing the human SSTR2 are plated in each well of a...


US Patent US10464918 (2019)

More data for this
Ligand-Target Pair
Somatostatin receptor type 2


(Homo sapiens (Human))
BDBM405588
PNG
(US10351547, Compound 2-2 | US10464918, Compound A)
Show SMILES NC1CCN(CC1)c1c(cnc2ccc(cc12)-c1cccc(C#N)c1O)-c1cc(F)cc(F)c1
Show InChI InChI=1S/C27H22F2N4O/c28-19-10-18(11-20(29)13-19)24-15-32-25-5-4-16(22-3-1-2-17(14-30)27(22)34)12-23(25)26(24)33-8-6-21(31)7-9-33/h1-5,10-13,15,21,34H,6-9,31H2
KEGG

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PC cid
PC sid
UniChem
US Patent
n/an/an/an/a<10n/an/an/an/a



CRINETICS PHARMACEUTICALS, INC.

US Patent


Assay Description
Four days prior to the assay, 5,000 Chinese hamster ovary cells (CHO-K1, ATCC #CCL-61) stably expressing the human SSTR2 are plated in each well of a...


US Patent US10464918 (2019)

More data for this
Ligand-Target Pair
Somatostatin receptor type 2


(Homo sapiens (Human))
BDBM419664
PNG
(US10464918, Compound 1-8)
Show SMILES Cc1ccnc(c1N)-c1ccc2ncc(-c3cccc(F)c3)c(N3CC[C@@H]4NCCO[C@H]4C3)c2c1
Show InChI InChI=1S/C28H28FN5O/c1-17-7-9-32-27(26(17)30)19-5-6-23-21(14-19)28(22(15-33-23)18-3-2-4-20(29)13-18)34-11-8-24-25(16-34)35-12-10-31-24/h2-7,9,13-15,24-25,31H,8,10-12,16,30H2,1H3/t24-,25-/m0/s1
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
UniChem
US Patent
n/an/an/an/a<10n/an/an/an/a



CRINETICS PHARMACEUTICALS, INC.

US Patent


Assay Description
Four days prior to the assay, 5,000 Chinese hamster ovary cells (CHO-K1, ATCC #CCL-61) stably expressing the human SSTR2 are plated in each well of a...


US Patent US10464918 (2019)

More data for this
Ligand-Target Pair
Somatostatin receptor type 2


(Homo sapiens (Human))
BDBM419666
PNG
(US10464918, Compound 1-10)
Show SMILES Cc1cc(F)cc(c1)-c1cnc2cc(F)c(cc2c1N1CCC(N)CC1)-c1cccc(C#N)c1O
Show InChI InChI=1S/C28H24F2N4O/c1-16-9-18(11-19(29)10-16)24-15-33-26-13-25(30)22(21-4-2-3-17(14-31)28(21)35)12-23(26)27(24)34-7-5-20(32)6-8-34/h2-4,9-13,15,20,35H,5-8,32H2,1H3
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
UniChem
US Patent
n/an/an/an/a<10n/an/an/an/a



CRINETICS PHARMACEUTICALS, INC.

US Patent


Assay Description
Four days prior to the assay, 5,000 Chinese hamster ovary cells (CHO-K1, ATCC #CCL-61) stably expressing the human SSTR2 are plated in each well of a...


US Patent US10464918 (2019)

More data for this
Ligand-Target Pair
Somatostatin receptor type 2


(Homo sapiens (Human))
BDBM419660
PNG
(US10464918, Compound 1-4)
Show SMILES Cc1cc(F)cc(c1)-c1cnc2ccc(cc2c1N1CC[C@@H]2NCCO[C@H]2C1)-c1nccc(C#N)c1N
Show InChI InChI=1S/C29H27FN6O/c1-17-10-20(12-21(30)11-17)23-15-35-24-3-2-18(28-27(32)19(14-31)4-6-34-28)13-22(24)29(23)36-8-5-25-26(16-36)37-9-7-33-25/h2-4,6,10-13,15,25-26,33H,5,7-9,16,32H2,1H3/t25-,26-/m0/s1
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
UniChem
US Patent
n/an/an/an/a<10n/an/an/an/a



CRINETICS PHARMACEUTICALS, INC.

US Patent


Assay Description
Four days prior to the assay, 5,000 Chinese hamster ovary cells (CHO-K1, ATCC #CCL-61) stably expressing the human SSTR2 are plated in each well of a...


US Patent US10464918 (2019)

More data for this
Ligand-Target Pair
Somatostatin receptor type 2


(Homo sapiens (Human))
BDBM419658
PNG
(US10464918, Compound 1-2)
Show SMILES CO\N=C\c1ccnc(c1N)-c1ccc2ncc(-c3cc(C)cc(F)c3)c(N3CC[C@@H]4NCCO[C@H]4C3)c2c1
Show InChI InChI=1S/C30H31FN6O2/c1-18-11-21(13-22(31)12-18)24-16-35-25-4-3-19(29-28(32)20(5-7-34-29)15-36-38-2)14-23(25)30(24)37-9-6-26-27(17-37)39-10-8-33-26/h3-5,7,11-16,26-27,33H,6,8-10,17,32H2,1-2H3/b36-15+/t26-,27-/m0/s1
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
UniChem
US Patent
n/an/an/an/a<10n/an/an/an/a



CRINETICS PHARMACEUTICALS, INC.

US Patent


Assay Description
Four days prior to the assay, 5,000 Chinese hamster ovary cells (CHO-K1, ATCC #CCL-61) stably expressing the human SSTR2 are plated in each well of a...


US Patent US10464918 (2019)

More data for this
Ligand-Target Pair
Somatostatin receptor type 2


(Homo sapiens (Human))
BDBM419662
PNG
(US10464918, Compound 1-6)
Show SMILES Nc1c(\C=N\O)ccnc1-c1ccc2ncc(-c3cc(F)cc(F)c3)c(N3CC[C@@H]4NCCO[C@H]4C3)c2c1
Show InChI InChI=1S/C28H26F2N6O2/c29-19-9-18(10-20(30)12-19)22-14-34-23-2-1-16(27-26(31)17(13-35-37)3-5-33-27)11-21(23)28(22)36-7-4-24-25(15-36)38-8-6-32-24/h1-3,5,9-14,24-25,32,37H,4,6-8,15,31H2/b35-13+/t24-,25-/m0/s1
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
KEGG
UniChem
US Patent
n/an/an/an/a<10n/an/an/an/a



CRINETICS PHARMACEUTICALS, INC.

US Patent


Assay Description
Four days prior to the assay, 5,000 Chinese hamster ovary cells (CHO-K1, ATCC #CCL-61) stably expressing the human SSTR2 are plated in each well of a...


US Patent US10464918 (2019)

More data for this
Ligand-Target Pair
Somatostatin receptor type 2


(Homo sapiens (Human))
BDBM419659
PNG
(US10464918, Compound 1-3)
Show SMILES CO\N=C\c1ccnc(c1N)-c1ccc2ncc(-c3cc(F)cc(Cl)c3)c(N3CC[C@@H]4NCCO[C@H]4C3)c2c1
Show InChI InChI=1S/C29H28ClFN6O2/c1-38-36-14-18-4-6-34-28(27(18)32)17-2-3-24-22(12-17)29(37-8-5-25-26(16-37)39-9-7-33-25)23(15-35-24)19-10-20(30)13-21(31)11-19/h2-4,6,10-15,25-26,33H,5,7-9,16,32H2,1H3/b36-14+/t25-,26-/m0/s1
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
UniChem
US Patent
n/an/an/an/a<10n/an/an/an/a



CRINETICS PHARMACEUTICALS, INC.

US Patent


Assay Description
Four days prior to the assay, 5,000 Chinese hamster ovary cells (CHO-K1, ATCC #CCL-61) stably expressing the human SSTR2 are plated in each well of a...


US Patent US10464918 (2019)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%