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Patent code US10464919

Compile Data Set for Download or QSAR

Found 346 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Tyrosine kinase non-receptor protein 2


(Homo sapiens (Human))
BDBM419721
PNG
(US10464919, Example 59)
Show SMILES [O-][N+](=O)c1ccc(N2CCN(Cc3ccc4c5NCCCc5c(=O)[nH]c4c3)CC2)c(F)c1
Show InChI InChI=1S/C23H24FN5O3/c24-19-13-16(29(31)32)4-6-21(19)28-10-8-27(9-11-28)14-15-3-5-17-20(12-15)26-23(30)18-2-1-7-25-22(17)18/h3-6,12-13,25H,1-2,7-11,14H2,(H,26,30)
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n/an/a 0.920n/an/an/an/an/an/a



Je Il Pharmaceutical Co., Ltd.

US Patent


Assay Description
The tankyrase-1 or tankyrase-2 enzyme inhibitory activities of the compounds of the present invention were assayed in the following manner by use of ...


US Patent US10464919 (2019)

More data for this
Ligand-Target Pair
Tyrosine kinase non-receptor protein 2


(Homo sapiens (Human))
BDBM419799
PNG
(US10464919, Example 137)
Show SMILES COc1cc(ncc1C#N)N1CCN(Cc2ccc3c4NCCCc4c(=O)[nH]c3c2)CC1
Show InChI InChI=1S/C24H26N6O2/c1-32-21-12-22(27-14-17(21)13-25)30-9-7-29(8-10-30)15-16-4-5-18-20(11-16)28-24(31)19-3-2-6-26-23(18)19/h4-5,11-12,14,26H,2-3,6-10,15H2,1H3,(H,28,31)
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n/an/a 0.950n/an/an/an/an/an/a



Je Il Pharmaceutical Co., Ltd.

US Patent


Assay Description
The tankyrase-1 or tankyrase-2 enzyme inhibitory activities of the compounds of the present invention were assayed in the following manner by use of ...


US Patent US10464919 (2019)

More data for this
Ligand-Target Pair
Tyrosine kinase non-receptor protein 2


(Homo sapiens (Human))
BDBM419844
PNG
(US10464919, Example 182)
Show SMILES Fc1cc(CN2CCN(CC2)c2ccc(nn2)C#N)cc2[nH]c(=O)c3CCCNc3c12
Show InChI InChI=1S/C22H22FN7O/c23-17-10-14(11-18-20(17)21-16(22(31)26-18)2-1-5-25-21)13-29-6-8-30(9-7-29)19-4-3-15(12-24)27-28-19/h3-4,10-11,25H,1-2,5-9,13H2,(H,26,31)
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n/an/a 1.26n/an/an/an/an/an/a



Je Il Pharmaceutical Co., Ltd.

US Patent


Assay Description
The tankyrase-1 or tankyrase-2 enzyme inhibitory activities of the compounds of the present invention were assayed in the following manner by use of ...


US Patent US10464919 (2019)

More data for this
Ligand-Target Pair
Tyrosine kinase non-receptor protein 2


(Homo sapiens (Human))
BDBM419794
PNG
(US10464919, Example 132)
Show SMILES O=c1[nH]c2cc(CN3CCN(CC3)c3ccc(nn3)C#N)ccc2c2NCCCc12
Show InChI InChI=1S/C22H23N7O/c23-13-16-4-6-20(27-26-16)29-10-8-28(9-11-29)14-15-3-5-17-19(12-15)25-22(30)18-2-1-7-24-21(17)18/h3-6,12,24H,1-2,7-11,14H2,(H,25,30)
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n/an/a 1.31n/an/an/an/an/an/a



Je Il Pharmaceutical Co., Ltd.

US Patent


Assay Description
The tankyrase-1 or tankyrase-2 enzyme inhibitory activities of the compounds of the present invention were assayed in the following manner by use of ...


US Patent US10464919 (2019)

More data for this
Ligand-Target Pair
Tyrosine kinase non-receptor protein 2


(Homo sapiens (Human))
BDBM419731
PNG
(US10464919, Example 69)
Show SMILES Fc1cc(ccc1N1CCN(Cc2ccc3c4NCCCc4c(=O)[nH]c3c2)CC1)C(=O)NC1CC1
Show InChI InChI=1S/C27H30FN5O2/c28-22-15-18(26(34)30-19-5-6-19)4-8-24(22)33-12-10-32(11-13-33)16-17-3-7-20-23(14-17)31-27(35)21-2-1-9-29-25(20)21/h3-4,7-8,14-15,19,29H,1-2,5-6,9-13,16H2,(H,30,34)(H,31,35)
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n/an/a 1.32n/an/an/an/an/an/a



Je Il Pharmaceutical Co., Ltd.

US Patent


Assay Description
The tankyrase-1 or tankyrase-2 enzyme inhibitory activities of the compounds of the present invention were assayed in the following manner by use of ...


US Patent US10464919 (2019)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TNK1


(Homo sapiens (Human))
BDBM419721
PNG
(US10464919, Example 59)
Show SMILES [O-][N+](=O)c1ccc(N2CCN(Cc3ccc4c5NCCCc5c(=O)[nH]c4c3)CC2)c(F)c1
Show InChI InChI=1S/C23H24FN5O3/c24-19-13-16(29(31)32)4-6-21(19)28-10-8-27(9-11-28)14-15-3-5-17-20(12-15)26-23(30)18-2-1-7-25-22(17)18/h3-6,12-13,25H,1-2,7-11,14H2,(H,26,30)
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n/an/a 1.37n/an/an/an/an/an/a



Je Il Pharmaceutical Co., Ltd.

US Patent


Assay Description
The tankyrase-1 or tankyrase-2 enzyme inhibitory activities of the compounds of the present invention were assayed in the following manner by use of ...


US Patent US10464919 (2019)

More data for this
Ligand-Target Pair
Tyrosine kinase non-receptor protein 2


(Homo sapiens (Human))
BDBM419781
PNG
(US10464919, Example 119)
Show SMILES [O-][N+](=O)c1ccc(cc1F)N1CCN(Cc2ccc3c4NCCCc4c(=O)[nH]c3c2)CC1
Show InChI InChI=1S/C23H24FN5O3/c24-19-13-16(4-6-21(19)29(31)32)28-10-8-27(9-11-28)14-15-3-5-17-20(12-15)26-23(30)18-2-1-7-25-22(17)18/h3-6,12-13,25H,1-2,7-11,14H2,(H,26,30)
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n/an/a 1.38n/an/an/an/an/an/a



Je Il Pharmaceutical Co., Ltd.

US Patent


Assay Description
The tankyrase-1 or tankyrase-2 enzyme inhibitory activities of the compounds of the present invention were assayed in the following manner by use of ...


US Patent US10464919 (2019)

More data for this
Ligand-Target Pair
Tyrosine kinase non-receptor protein 2


(Homo sapiens (Human))
BDBM419751
PNG
(US10464919, Example 89)
Show SMILES O=c1[nH]c2cc(CN3CCN(CC3)c3ccc(cn3)C#N)ccc2c2NCCCc12
Show InChI InChI=1S/C23H24N6O/c24-13-17-4-6-21(26-14-17)29-10-8-28(9-11-29)15-16-3-5-18-20(12-16)27-23(30)19-2-1-7-25-22(18)19/h3-6,12,14,25H,1-2,7-11,15H2,(H,27,30)
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n/an/a 1.48n/an/an/an/an/an/a



Je Il Pharmaceutical Co., Ltd.

US Patent


Assay Description
The tankyrase-1 or tankyrase-2 enzyme inhibitory activities of the compounds of the present invention were assayed in the following manner by use of ...


US Patent US10464919 (2019)

More data for this
Ligand-Target Pair
Tyrosine kinase non-receptor protein 2


(Homo sapiens (Human))
BDBM419791
PNG
(US10464919, Example 129)
Show SMILES O=c1[nH]c2cc(CN3CCN(CC3)c3cnc(cn3)C#N)ccc2c2NCCCc12
Show InChI InChI=1S/C22H23N7O/c23-11-16-12-26-20(13-25-16)29-8-6-28(7-9-29)14-15-3-4-17-19(10-15)27-22(30)18-2-1-5-24-21(17)18/h3-4,10,12-13,24H,1-2,5-9,14H2,(H,27,30)
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n/an/a 1.65n/an/an/an/an/an/a



Je Il Pharmaceutical Co., Ltd.

US Patent


Assay Description
The tankyrase-1 or tankyrase-2 enzyme inhibitory activities of the compounds of the present invention were assayed in the following manner by use of ...


US Patent US10464919 (2019)

More data for this
Ligand-Target Pair
Tyrosine kinase non-receptor protein 2


(Homo sapiens (Human))
BDBM419758
PNG
(US10464919, Example 96)
Show SMILES CCNC(=O)c1ccc(nc1)N1CCN(Cc2ccc3c4NCCCc4c(=O)[nH]c3c2)CC1
Show InChI InChI=1S/C25H30N6O2/c1-2-26-24(32)18-6-8-22(28-15-18)31-12-10-30(11-13-31)16-17-5-7-19-21(14-17)29-25(33)20-4-3-9-27-23(19)20/h5-8,14-15,27H,2-4,9-13,16H2,1H3,(H,26,32)(H,29,33)
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n/an/a 1.75n/an/an/an/an/an/a



Je Il Pharmaceutical Co., Ltd.

US Patent


Assay Description
The tankyrase-1 or tankyrase-2 enzyme inhibitory activities of the compounds of the present invention were assayed in the following manner by use of ...


US Patent US10464919 (2019)

More data for this
Ligand-Target Pair
Tyrosine kinase non-receptor protein 2


(Homo sapiens (Human))
BDBM419797
PNG
(US10464919, Example 135)
Show SMILES Clc1cc(ncc1C#N)N1CCN(Cc2ccc3c4NCCCc4c(=O)[nH]c3c2)CC1
Show InChI InChI=1S/C23H23ClN6O/c24-19-11-21(27-13-16(19)12-25)30-8-6-29(7-9-30)14-15-3-4-17-20(10-15)28-23(31)18-2-1-5-26-22(17)18/h3-4,10-11,13,26H,1-2,5-9,14H2,(H,28,31)
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n/an/a 1.75n/an/an/an/an/an/a



Je Il Pharmaceutical Co., Ltd.

US Patent


Assay Description
The tankyrase-1 or tankyrase-2 enzyme inhibitory activities of the compounds of the present invention were assayed in the following manner by use of ...


US Patent US10464919 (2019)

More data for this
Ligand-Target Pair
Tyrosine kinase non-receptor protein 2


(Homo sapiens (Human))
BDBM419740
PNG
(US10464919, Example 78)
Show SMILES Fc1cc(ccc1C(=O)NC1CC1)N1CCN(Cc2ccc3c4NCCCc4c(=O)[nH]c3c2)CC1
Show InChI InChI=1S/C27H30FN5O2/c28-23-15-19(6-8-20(23)26(34)30-18-4-5-18)33-12-10-32(11-13-33)16-17-3-7-21-24(14-17)31-27(35)22-2-1-9-29-25(21)22/h3,6-8,14-15,18,29H,1-2,4-5,9-13,16H2,(H,30,34)(H,31,35)
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n/an/a 1.87n/an/an/an/an/an/a



Je Il Pharmaceutical Co., Ltd.

US Patent


Assay Description
The tankyrase-1 or tankyrase-2 enzyme inhibitory activities of the compounds of the present invention were assayed in the following manner by use of ...


US Patent US10464919 (2019)

More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 1


(Homo sapiens (Human))
BDBM419721
PNG
(US10464919, Example 59)
Show SMILES [O-][N+](=O)c1ccc(N2CCN(Cc3ccc4c5NCCCc5c(=O)[nH]c4c3)CC2)c(F)c1
Show InChI InChI=1S/C23H24FN5O3/c24-19-13-16(29(31)32)4-6-21(19)28-10-8-27(9-11-28)14-15-3-5-17-20(12-15)26-23(30)18-2-1-7-25-22(17)18/h3-6,12-13,25H,1-2,7-11,14H2,(H,26,30)
PDB
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n/an/a 1.95n/an/an/an/an/an/a



Je Il Pharmaceutical Co., Ltd.

US Patent


Assay Description
The PARP-1 enzyme inhibitory activities of the compounds of the present invention were assayed in the following manner by use of a kit (cat. 80551) p...


US Patent US10464919 (2019)

More data for this
Ligand-Target Pair
Tyrosine kinase non-receptor protein 2


(Homo sapiens (Human))
BDBM419832
PNG
(US10464919, Example 170)
Show SMILES Fc1cc(CN2CCN(CC2)c2ccc(cn2)C#N)cc2[nH]c(=O)c3CCCNc3c12
Show InChI InChI=1S/C23H23FN6O/c24-18-10-16(11-19-21(18)22-17(23(31)28-19)2-1-5-26-22)14-29-6-8-30(9-7-29)20-4-3-15(12-25)13-27-20/h3-4,10-11,13,26H,1-2,5-9,14H2,(H,28,31)
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n/an/a 1.96n/an/an/an/an/an/a



Je Il Pharmaceutical Co., Ltd.

US Patent


Assay Description
The tankyrase-1 or tankyrase-2 enzyme inhibitory activities of the compounds of the present invention were assayed in the following manner by use of ...


US Patent US10464919 (2019)

More data for this
Ligand-Target Pair
Tyrosine kinase non-receptor protein 2


(Homo sapiens (Human))
BDBM419755
PNG
(US10464919, Example 93)
Show SMILES Clc1ccc(nn1)N1CCN(Cc2ccc3c4NCCCc4c(=O)[nH]c3c2)CC1
Show InChI InChI=1S/C21H23ClN6O/c22-18-5-6-19(26-25-18)28-10-8-27(9-11-28)13-14-3-4-15-17(12-14)24-21(29)16-2-1-7-23-20(15)16/h3-6,12,23H,1-2,7-11,13H2,(H,24,29)
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n/an/a 1.97n/an/an/an/an/an/a



Je Il Pharmaceutical Co., Ltd.

US Patent


Assay Description
The tankyrase-1 or tankyrase-2 enzyme inhibitory activities of the compounds of the present invention were assayed in the following manner by use of ...


US Patent US10464919 (2019)

More data for this
Ligand-Target Pair
Tyrosine kinase non-receptor protein 2


(Homo sapiens (Human))
BDBM419761
PNG
(US10464919, Example 99)
Show SMILES CCOC(=O)c1csc(n1)N1CCN(Cc2ccc3c4NCCCc4c(=O)[nH]c3c2)CC1
Show InChI InChI=1S/C23H27N5O3S/c1-2-31-22(30)19-14-32-23(26-19)28-10-8-27(9-11-28)13-15-5-6-16-18(12-15)25-21(29)17-4-3-7-24-20(16)17/h5-6,12,14,24H,2-4,7-11,13H2,1H3,(H,25,29)
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n/an/a 1.99n/an/an/an/an/an/a



Je Il Pharmaceutical Co., Ltd.

US Patent


Assay Description
The tankyrase-1 or tankyrase-2 enzyme inhibitory activities of the compounds of the present invention were assayed in the following manner by use of ...


US Patent US10464919 (2019)

More data for this
Ligand-Target Pair
Tyrosine kinase non-receptor protein 2


(Homo sapiens (Human))
BDBM419765
PNG
(US10464919, Example 103)
Show SMILES Fc1cc(ccc1C#N)N1C[C@@H]2C[C@H]1CN2Cc1ccc2c3NCCCc3c(=O)[nH]c2c1
Show InChI InChI=1/C25H24FN5O/c26-22-10-17(5-4-16(22)11-27)31-14-18-9-19(31)13-30(18)12-15-3-6-20-23(8-15)29-25(32)21-2-1-7-28-24(20)21/h3-6,8,10,18-19,28H,1-2,7,9,12-14H2,(H,29,32)/t18-,19-/s2
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n/an/a 2.10n/an/an/an/an/an/a



Je Il Pharmaceutical Co., Ltd.

US Patent


Assay Description
The tankyrase-1 or tankyrase-2 enzyme inhibitory activities of the compounds of the present invention were assayed in the following manner by use of ...


US Patent US10464919 (2019)

More data for this
Ligand-Target Pair
Tyrosine kinase non-receptor protein 2


(Homo sapiens (Human))
BDBM419842
PNG
(US10464919, Example 180)
Show SMILES Fc1cc(CN2CCN(CC2)c2ccc(nc2)C#N)cc2[nH]c(=O)c3CCCNc3c12
Show InChI InChI=1S/C23H23FN6O/c24-19-10-15(11-20-21(19)22-18(23(31)28-20)2-1-5-26-22)14-29-6-8-30(9-7-29)17-4-3-16(12-25)27-13-17/h3-4,10-11,13,26H,1-2,5-9,14H2,(H,28,31)
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n/an/a 2.12n/an/an/an/an/an/a



Je Il Pharmaceutical Co., Ltd.

US Patent


Assay Description
The tankyrase-1 or tankyrase-2 enzyme inhibitory activities of the compounds of the present invention were assayed in the following manner by use of ...


US Patent US10464919 (2019)

More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 1


(Homo sapiens (Human))
BDBM419751
PNG
(US10464919, Example 89)
Show SMILES O=c1[nH]c2cc(CN3CCN(CC3)c3ccc(cn3)C#N)ccc2c2NCCCc12
Show InChI InChI=1S/C23H24N6O/c24-13-17-4-6-21(26-14-17)29-10-8-28(9-11-29)15-16-3-5-18-20(12-16)27-23(30)19-2-1-7-25-22(18)19/h3-6,12,14,25H,1-2,7-11,15H2,(H,27,30)
PDB
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n/an/a 2.35n/an/an/an/an/an/a



Je Il Pharmaceutical Co., Ltd.

US Patent


Assay Description
The PARP-1 enzyme inhibitory activities of the compounds of the present invention were assayed in the following manner by use of a kit (cat. 80551) p...


US Patent US10464919 (2019)

More data for this
Ligand-Target Pair
Tyrosine kinase non-receptor protein 2


(Homo sapiens (Human))
BDBM419784
PNG
(US10464919, Example 122)
Show SMILES CS(=O)(=O)c1ccc(nc1)N1CCN(Cc2ccc3c4NCCCc4c(=O)[nH]c3c2)CC1
Show InChI InChI=1S/C23H27N5O3S/c1-32(30,31)17-5-7-21(25-14-17)28-11-9-27(10-12-28)15-16-4-6-18-20(13-16)26-23(29)19-3-2-8-24-22(18)19/h4-7,13-14,24H,2-3,8-12,15H2,1H3,(H,26,29)
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n/an/a 2.37n/an/an/an/an/an/a



Je Il Pharmaceutical Co., Ltd.

US Patent


Assay Description
The tankyrase-1 or tankyrase-2 enzyme inhibitory activities of the compounds of the present invention were assayed in the following manner by use of ...


US Patent US10464919 (2019)

More data for this
Ligand-Target Pair
Tyrosine kinase non-receptor protein 2


(Homo sapiens (Human))
BDBM419785
PNG
(US10464919, Example 123)
Show SMILES O=c1[nH]c2cc(CN3CCN(CC3)c3ccc(nc3)C#N)ccc2c2NCCCc12
Show InChI InChI=1S/C23H24N6O/c24-13-17-4-5-18(14-26-17)29-10-8-28(9-11-29)15-16-3-6-19-21(12-16)27-23(30)20-2-1-7-25-22(19)20/h3-6,12,14,25H,1-2,7-11,15H2,(H,27,30)
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n/an/a 2.38n/an/an/an/an/an/a



Je Il Pharmaceutical Co., Ltd.

US Patent


Assay Description
The tankyrase-1 or tankyrase-2 enzyme inhibitory activities of the compounds of the present invention were assayed in the following manner by use of ...


US Patent US10464919 (2019)

More data for this
Ligand-Target Pair
Tyrosine kinase non-receptor protein 2


(Homo sapiens (Human))
BDBM419804
PNG
(US10464919, Example 142)
Show SMILES O=c1[nH]c2cc(CN3CCN(CC3)c3ncc(s3)C#N)ccc2c2NCCCc12
Show InChI InChI=1S/C21H22N6OS/c22-11-15-12-24-21(29-15)27-8-6-26(7-9-27)13-14-3-4-16-18(10-14)25-20(28)17-2-1-5-23-19(16)17/h3-4,10,12,23H,1-2,5-9,13H2,(H,25,28)
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n/an/a 2.45n/an/an/an/an/an/a



Je Il Pharmaceutical Co., Ltd.

US Patent


Assay Description
The tankyrase-1 or tankyrase-2 enzyme inhibitory activities of the compounds of the present invention were assayed in the following manner by use of ...


US Patent US10464919 (2019)

More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 1


(Homo sapiens (Human))
BDBM419812
PNG
(US10464919, Example 150)
Show SMILES O=c1[nH]c2cc(CN3CCN(CC3)c3ccc4cc[nH]c4c3)ccc2c2NCCCc12
Show InChI InChI=1S/C25H27N5O/c31-25-21-2-1-8-27-24(21)20-6-3-17(14-23(20)28-25)16-29-10-12-30(13-11-29)19-5-4-18-7-9-26-22(18)15-19/h3-7,9,14-15,26-27H,1-2,8,10-13,16H2,(H,28,31)
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n/an/a 2.49n/an/an/an/an/an/a



Je Il Pharmaceutical Co., Ltd.

US Patent


Assay Description
The PARP-1 enzyme inhibitory activities of the compounds of the present invention were assayed in the following manner by use of a kit (cat. 80551) p...


US Patent US10464919 (2019)

More data for this
Ligand-Target Pair
Tyrosine kinase non-receptor protein 2


(Homo sapiens (Human))
BDBM419803
PNG
(US10464919, Example 141)
Show SMILES CCOC(=O)c1cnc(s1)N1CCN(Cc2ccc3c4NCCCc4c(=O)[nH]c3c2)CC1
Show InChI InChI=1S/C23H27N5O3S/c1-2-31-22(30)19-13-25-23(32-19)28-10-8-27(9-11-28)14-15-5-6-16-18(12-15)26-21(29)17-4-3-7-24-20(16)17/h5-6,12-13,24H,2-4,7-11,14H2,1H3,(H,26,29)
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n/an/a 2.62n/an/an/an/an/an/a



Je Il Pharmaceutical Co., Ltd.

US Patent


Assay Description
The tankyrase-1 or tankyrase-2 enzyme inhibitory activities of the compounds of the present invention were assayed in the following manner by use of ...


US Patent US10464919 (2019)

More data for this
Ligand-Target Pair
Tyrosine kinase non-receptor protein 2


(Homo sapiens (Human))
BDBM419796
PNG
(US10464919, Example 134)
Show SMILES Clc1cc(N2CCN(Cc3ccc4c5NCCCc5c(=O)[nH]c4c3)CC2)c(cn1)C#N
Show InChI InChI=1S/C23H23ClN6O/c24-21-11-20(16(12-25)13-27-21)30-8-6-29(7-9-30)14-15-3-4-17-19(10-15)28-23(31)18-2-1-5-26-22(17)18/h3-4,10-11,13,26H,1-2,5-9,14H2,(H,28,31)
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n/an/a 2.70n/an/an/an/an/an/a



Je Il Pharmaceutical Co., Ltd.

US Patent


Assay Description
The tankyrase-1 or tankyrase-2 enzyme inhibitory activities of the compounds of the present invention were assayed in the following manner by use of ...


US Patent US10464919 (2019)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TNK1


(Homo sapiens (Human))
BDBM419794
PNG
(US10464919, Example 132)
Show SMILES O=c1[nH]c2cc(CN3CCN(CC3)c3ccc(nn3)C#N)ccc2c2NCCCc12
Show InChI InChI=1S/C22H23N7O/c23-13-16-4-6-20(27-26-16)29-10-8-28(9-11-29)14-15-3-5-17-19(12-15)25-22(30)18-2-1-7-24-21(17)18/h3-6,12,24H,1-2,7-11,14H2,(H,25,30)
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n/an/a 2.77n/an/an/an/an/an/a



Je Il Pharmaceutical Co., Ltd.

US Patent


Assay Description
The tankyrase-1 or tankyrase-2 enzyme inhibitory activities of the compounds of the present invention were assayed in the following manner by use of ...


US Patent US10464919 (2019)

More data for this
Ligand-Target Pair
Tyrosine kinase non-receptor protein 2


(Homo sapiens (Human))
BDBM419793
PNG
(US10464919, Example 131)
Show SMILES COc1ccc(nn1)N1CCN(Cc2ccc3c4NCCCc4c(=O)[nH]c3c2)CC1
Show InChI InChI=1S/C22H26N6O2/c1-30-20-7-6-19(25-26-20)28-11-9-27(10-12-28)14-15-4-5-16-18(13-15)24-22(29)17-3-2-8-23-21(16)17/h4-7,13,23H,2-3,8-12,14H2,1H3,(H,24,29)
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n/an/a 2.81n/an/an/an/an/an/a



Je Il Pharmaceutical Co., Ltd.

US Patent


Assay Description
The tankyrase-1 or tankyrase-2 enzyme inhibitory activities of the compounds of the present invention were assayed in the following manner by use of ...


US Patent US10464919 (2019)

More data for this
Ligand-Target Pair
Tyrosine kinase non-receptor protein 2


(Homo sapiens (Human))
BDBM419738
PNG
(US10464919, Example 76)
Show SMILES CNC(=O)c1ccc(cc1F)N1CCN(Cc2ccc3c4NCCCc4c(=O)[nH]c3c2)CC1
Show InChI InChI=1S/C25H28FN5O2/c1-27-24(32)18-7-5-17(14-21(18)26)31-11-9-30(10-12-31)15-16-4-6-19-22(13-16)29-25(33)20-3-2-8-28-23(19)20/h4-7,13-14,28H,2-3,8-12,15H2,1H3,(H,27,32)(H,29,33)
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n/an/a 2.86n/an/an/an/an/an/a



Je Il Pharmaceutical Co., Ltd.

US Patent


Assay Description
The tankyrase-1 or tankyrase-2 enzyme inhibitory activities of the compounds of the present invention were assayed in the following manner by use of ...


US Patent US10464919 (2019)

More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 1


(Homo sapiens (Human))
BDBM419731
PNG
(US10464919, Example 69)
Show SMILES Fc1cc(ccc1N1CCN(Cc2ccc3c4NCCCc4c(=O)[nH]c3c2)CC1)C(=O)NC1CC1
Show InChI InChI=1S/C27H30FN5O2/c28-22-15-18(26(34)30-19-5-6-19)4-8-24(22)33-12-10-32(11-13-33)16-17-3-7-20-23(14-17)31-27(35)21-2-1-9-29-25(20)21/h3-4,7-8,14-15,19,29H,1-2,5-6,9-13,16H2,(H,30,34)(H,31,35)
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n/an/a 3.04n/an/an/an/an/an/a



Je Il Pharmaceutical Co., Ltd.

US Patent


Assay Description
The PARP-1 enzyme inhibitory activities of the compounds of the present invention were assayed in the following manner by use of a kit (cat. 80551) p...


US Patent US10464919 (2019)

More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 1


(Homo sapiens (Human))
BDBM419802
PNG
(US10464919, Example 140 | US10464919, Example 186)
Show SMILES O=c1[nH]c2cc(CN3CCN(CC3)c3ccc(s3)C#N)ccc2c2NCCCc12
Show InChI InChI=1S/C22H23N5OS/c23-13-16-4-6-20(29-16)27-10-8-26(9-11-27)14-15-3-5-17-19(12-15)25-22(28)18-2-1-7-24-21(17)18/h3-6,12,24H,1-2,7-11,14H2,(H,25,28)
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n/an/a 3.05n/an/an/an/an/an/a



Je Il Pharmaceutical Co., Ltd.

US Patent


Assay Description
The PARP-1 enzyme inhibitory activities of the compounds of the present invention were assayed in the following manner by use of a kit (cat. 80551) p...


US Patent US10464919 (2019)

More data for this
Ligand-Target Pair
Tyrosine kinase non-receptor protein 2


(Homo sapiens (Human))
BDBM419787
PNG
(US10464919, Example 125)
Show SMILES O=c1[nH]c2cc(CN3CCN(CC3)c3ncccc3C#N)ccc2c2NCCCc12
Show InChI InChI=1S/C23H24N6O/c24-14-17-3-1-8-26-22(17)29-11-9-28(10-12-29)15-16-5-6-18-20(13-16)27-23(30)19-4-2-7-25-21(18)19/h1,3,5-6,8,13,25H,2,4,7,9-12,15H2,(H,27,30)
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n/an/a 3.18n/an/an/an/an/an/a



Je Il Pharmaceutical Co., Ltd.

US Patent


Assay Description
The tankyrase-1 or tankyrase-2 enzyme inhibitory activities of the compounds of the present invention were assayed in the following manner by use of ...


US Patent US10464919 (2019)

More data for this
Ligand-Target Pair
Tyrosine kinase non-receptor protein 2


(Homo sapiens (Human))
BDBM419807
PNG
(US10464919, Example 145)
Show SMILES O=c1[nH]c2cc(CN3CCN(CC3)c3nc(ns3)C#N)ccc2c2NCCCc12
Show InChI InChI=1S/C20H21N7OS/c21-11-17-24-20(29-25-17)27-8-6-26(7-9-27)12-13-3-4-14-16(10-13)23-19(28)15-2-1-5-22-18(14)15/h3-4,10,22H,1-2,5-9,12H2,(H,23,28)
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n/an/a 3.24n/an/an/an/an/an/a



Je Il Pharmaceutical Co., Ltd.

US Patent


Assay Description
The tankyrase-1 or tankyrase-2 enzyme inhibitory activities of the compounds of the present invention were assayed in the following manner by use of ...


US Patent US10464919 (2019)

More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 1


(Homo sapiens (Human))
BDBM419755
PNG
(US10464919, Example 93)
Show SMILES Clc1ccc(nn1)N1CCN(Cc2ccc3c4NCCCc4c(=O)[nH]c3c2)CC1
Show InChI InChI=1S/C21H23ClN6O/c22-18-5-6-19(26-25-18)28-10-8-27(9-11-28)13-14-3-4-15-17(12-14)24-21(29)16-2-1-7-23-20(15)16/h3-6,12,23H,1-2,7-11,13H2,(H,24,29)
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n/an/a 3.25n/an/an/an/an/an/a



Je Il Pharmaceutical Co., Ltd.

US Patent


Assay Description
The PARP-1 enzyme inhibitory activities of the compounds of the present invention were assayed in the following manner by use of a kit (cat. 80551) p...


US Patent US10464919 (2019)

More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 1


(Homo sapiens (Human))
BDBM419832
PNG
(US10464919, Example 170)
Show SMILES Fc1cc(CN2CCN(CC2)c2ccc(cn2)C#N)cc2[nH]c(=O)c3CCCNc3c12
Show InChI InChI=1S/C23H23FN6O/c24-18-10-16(11-19-21(18)22-17(23(31)28-19)2-1-5-26-22)14-29-6-8-30(9-7-29)20-4-3-15(12-25)13-27-20/h3-4,10-11,13,26H,1-2,5-9,14H2,(H,28,31)
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n/an/a 3.30n/an/an/an/an/an/a



Je Il Pharmaceutical Co., Ltd.

US Patent


Assay Description
The PARP-1 enzyme inhibitory activities of the compounds of the present invention were assayed in the following manner by use of a kit (cat. 80551) p...


US Patent US10464919 (2019)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TNK1


(Homo sapiens (Human))
BDBM419844
PNG
(US10464919, Example 182)
Show SMILES Fc1cc(CN2CCN(CC2)c2ccc(nn2)C#N)cc2[nH]c(=O)c3CCCNc3c12
Show InChI InChI=1S/C22H22FN7O/c23-17-10-14(11-18-20(17)21-16(22(31)26-18)2-1-5-25-21)13-29-6-8-30(9-7-29)19-4-3-15(12-24)27-28-19/h3-4,10-11,25H,1-2,5-9,13H2,(H,26,31)
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n/an/a 3.33n/an/an/an/an/an/a



Je Il Pharmaceutical Co., Ltd.

US Patent


Assay Description
The tankyrase-1 or tankyrase-2 enzyme inhibitory activities of the compounds of the present invention were assayed in the following manner by use of ...


US Patent US10464919 (2019)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TNK1


(Homo sapiens (Human))
BDBM419799
PNG
(US10464919, Example 137)
Show SMILES COc1cc(ncc1C#N)N1CCN(Cc2ccc3c4NCCCc4c(=O)[nH]c3c2)CC1
Show InChI InChI=1S/C24H26N6O2/c1-32-21-12-22(27-14-17(21)13-25)30-9-7-29(8-10-30)15-16-4-5-18-20(11-16)28-24(31)19-3-2-6-26-23(18)19/h4-5,11-12,14,26H,2-3,6-10,15H2,1H3,(H,28,31)
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n/an/a 3.36n/an/an/an/an/an/a



Je Il Pharmaceutical Co., Ltd.

US Patent


Assay Description
The tankyrase-1 or tankyrase-2 enzyme inhibitory activities of the compounds of the present invention were assayed in the following manner by use of ...


US Patent US10464919 (2019)

More data for this
Ligand-Target Pair
Tyrosine kinase non-receptor protein 2


(Homo sapiens (Human))
BDBM419726
PNG
(US10464919, Example 64)
Show SMILES CCNC(=O)c1ccc(N2CCN(Cc3ccc4c5NCCCc5c(=O)[nH]c4c3)CC2)c(C)c1
Show InChI InChI=1S/C27H33N5O2/c1-3-28-26(33)20-7-9-24(18(2)15-20)32-13-11-31(12-14-32)17-19-6-8-21-23(16-19)30-27(34)22-5-4-10-29-25(21)22/h6-9,15-16,29H,3-5,10-14,17H2,1-2H3,(H,28,33)(H,30,34)
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n/an/a 3.38n/an/an/an/an/an/a



Je Il Pharmaceutical Co., Ltd.

US Patent


Assay Description
The tankyrase-1 or tankyrase-2 enzyme inhibitory activities of the compounds of the present invention were assayed in the following manner by use of ...


US Patent US10464919 (2019)

More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 1


(Homo sapiens (Human))
BDBM419785
PNG
(US10464919, Example 123)
Show SMILES O=c1[nH]c2cc(CN3CCN(CC3)c3ccc(nc3)C#N)ccc2c2NCCCc12
Show InChI InChI=1S/C23H24N6O/c24-13-17-4-5-18(14-26-17)29-10-8-28(9-11-29)15-16-3-6-19-21(12-16)27-23(30)20-2-1-7-25-22(19)20/h3-6,12,14,25H,1-2,7-11,15H2,(H,27,30)
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n/an/a 3.49n/an/an/an/an/an/a



Je Il Pharmaceutical Co., Ltd.

US Patent


Assay Description
The PARP-1 enzyme inhibitory activities of the compounds of the present invention were assayed in the following manner by use of a kit (cat. 80551) p...


US Patent US10464919 (2019)

More data for this
Ligand-Target Pair
Tyrosine kinase non-receptor protein 2


(Homo sapiens (Human))
BDBM419775
PNG
(US10464919, Example 113)
Show SMILES C[C@H]1CN(CCN1Cc1ccc2c3NCCCc3c(=O)[nH]c2c1)c1ccc(C#N)c(F)c1
Show InChI InChI=1/C25H26FN5O/c1-16-14-31(19-6-5-18(13-27)22(26)12-19)10-9-30(16)15-17-4-7-20-23(11-17)29-25(32)21-3-2-8-28-24(20)21/h4-7,11-12,16,28H,2-3,8-10,14-15H2,1H3,(H,29,32)/t16-/s2
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n/an/a 3.49n/an/an/an/an/an/a



Je Il Pharmaceutical Co., Ltd.

US Patent


Assay Description
The tankyrase-1 or tankyrase-2 enzyme inhibitory activities of the compounds of the present invention were assayed in the following manner by use of ...


US Patent US10464919 (2019)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TNK1


(Homo sapiens (Human))
BDBM419755
PNG
(US10464919, Example 93)
Show SMILES Clc1ccc(nn1)N1CCN(Cc2ccc3c4NCCCc4c(=O)[nH]c3c2)CC1
Show InChI InChI=1S/C21H23ClN6O/c22-18-5-6-19(26-25-18)28-10-8-27(9-11-28)13-14-3-4-15-17(12-14)24-21(29)16-2-1-7-23-20(15)16/h3-6,12,23H,1-2,7-11,13H2,(H,24,29)
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n/an/a 3.59n/an/an/an/an/an/a



Je Il Pharmaceutical Co., Ltd.

US Patent


Assay Description
The tankyrase-1 or tankyrase-2 enzyme inhibitory activities of the compounds of the present invention were assayed in the following manner by use of ...


US Patent US10464919 (2019)

More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 1


(Homo sapiens (Human))
BDBM419794
PNG
(US10464919, Example 132)
Show SMILES O=c1[nH]c2cc(CN3CCN(CC3)c3ccc(nn3)C#N)ccc2c2NCCCc12
Show InChI InChI=1S/C22H23N7O/c23-13-16-4-6-20(27-26-16)29-10-8-28(9-11-29)14-15-3-5-17-19(12-15)25-22(30)18-2-1-7-24-21(17)18/h3-6,12,24H,1-2,7-11,14H2,(H,25,30)
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n/an/a 3.60n/an/an/an/an/an/a



Je Il Pharmaceutical Co., Ltd.

US Patent


Assay Description
The PARP-1 enzyme inhibitory activities of the compounds of the present invention were assayed in the following manner by use of a kit (cat. 80551) p...


US Patent US10464919 (2019)

More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 1


(Homo sapiens (Human))
BDBM419797
PNG
(US10464919, Example 135)
Show SMILES Clc1cc(ncc1C#N)N1CCN(Cc2ccc3c4NCCCc4c(=O)[nH]c3c2)CC1
Show InChI InChI=1S/C23H23ClN6O/c24-19-11-21(27-13-16(19)12-25)30-8-6-29(7-9-30)14-15-3-4-17-20(10-15)28-23(31)18-2-1-5-26-22(17)18/h3-4,10-11,13,26H,1-2,5-9,14H2,(H,28,31)
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n/an/a 3.66n/an/an/an/an/an/a



Je Il Pharmaceutical Co., Ltd.

US Patent


Assay Description
The PARP-1 enzyme inhibitory activities of the compounds of the present invention were assayed in the following manner by use of a kit (cat. 80551) p...


US Patent US10464919 (2019)

More data for this
Ligand-Target Pair
Tyrosine kinase non-receptor protein 2


(Homo sapiens (Human))
BDBM419759
PNG
(US10464919, Example 97)
Show SMILES O=C(NC1CC1)c1ccc(nc1)N1CCN(Cc2ccc3c4NCCCc4c(=O)[nH]c3c2)CC1
Show InChI InChI=1S/C26H30N6O2/c33-25(29-19-5-6-19)18-4-8-23(28-15-18)32-12-10-31(11-13-32)16-17-3-7-20-22(14-17)30-26(34)21-2-1-9-27-24(20)21/h3-4,7-8,14-15,19,27H,1-2,5-6,9-13,16H2,(H,29,33)(H,30,34)
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n/an/a 3.70n/an/an/an/an/an/a



Je Il Pharmaceutical Co., Ltd.

US Patent


Assay Description
The tankyrase-1 or tankyrase-2 enzyme inhibitory activities of the compounds of the present invention were assayed in the following manner by use of ...


US Patent US10464919 (2019)

More data for this
Ligand-Target Pair
Tyrosine kinase non-receptor protein 2


(Homo sapiens (Human))
BDBM419718
PNG
(US10464919, Example 56)
Show SMILES CC(=O)c1cc(ccc1N1CCN(Cc2ccc3c4NCCCc4c(=O)[nH]c3c2)CC1)C#N
Show InChI InChI=1S/C26H27N5O2/c1-17(32)22-13-18(15-27)5-7-24(22)31-11-9-30(10-12-31)16-19-4-6-20-23(14-19)29-26(33)21-3-2-8-28-25(20)21/h4-7,13-14,28H,2-3,8-12,16H2,1H3,(H,29,33)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
UniChem
US Patent
n/an/a 3.78n/an/an/an/an/an/a



Je Il Pharmaceutical Co., Ltd.

US Patent


Assay Description
The tankyrase-1 or tankyrase-2 enzyme inhibitory activities of the compounds of the present invention were assayed in the following manner by use of ...


US Patent US10464919 (2019)

More data for this
Ligand-Target Pair
Tyrosine kinase non-receptor protein 2


(Homo sapiens (Human))
BDBM419723
PNG
(US10464919, Example 61)
Show SMILES Clc1cc(ccc1C#N)N1CCN(Cc2ccc3c4NCCCc4c(=O)[nH]c3c2)CC1
Show InChI InChI=1S/C24H24ClN5O/c25-21-13-18(5-4-17(21)14-26)30-10-8-29(9-11-30)15-16-3-6-19-22(12-16)28-24(31)20-2-1-7-27-23(19)20/h3-6,12-13,27H,1-2,7-11,15H2,(H,28,31)
PDB
MMDB

KEGG

UniProtKB/SwissProt

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DrugBank
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US Patent
n/an/a 3.80n/an/an/an/an/an/a



Je Il Pharmaceutical Co., Ltd.

US Patent


Assay Description
The tankyrase-1 or tankyrase-2 enzyme inhibitory activities of the compounds of the present invention were assayed in the following manner by use of ...


US Patent US10464919 (2019)

More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 1


(Homo sapiens (Human))
BDBM419763
PNG
(US10464919, Example 101)
Show SMILES Fc1cc(ccc1C#N)N1CC2CCC(C1)N2Cc1ccc2c3NCCCc3c(=O)[nH]c2c1
Show InChI InChI=1/C26H26FN5O/c27-23-11-18(5-4-17(23)12-28)31-14-19-6-7-20(15-31)32(19)13-16-3-8-21-24(10-16)30-26(33)22-2-1-9-29-25(21)22/h3-5,8,10-11,19-20,29H,1-2,6-7,9,13-15H2,(H,30,33)
PDB
MMDB

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
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UniChem
US Patent
n/an/a 3.87n/an/an/an/an/an/a



Je Il Pharmaceutical Co., Ltd.

US Patent


Assay Description
The PARP-1 enzyme inhibitory activities of the compounds of the present invention were assayed in the following manner by use of a kit (cat. 80551) p...


US Patent US10464919 (2019)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TNK1


(Homo sapiens (Human))
BDBM419785
PNG
(US10464919, Example 123)
Show SMILES O=c1[nH]c2cc(CN3CCN(CC3)c3ccc(nc3)C#N)ccc2c2NCCCc12
Show InChI InChI=1S/C23H24N6O/c24-13-17-4-5-18(14-26-17)29-10-8-28(9-11-29)15-16-3-6-19-21(12-16)27-23(30)20-2-1-7-25-22(19)20/h3-6,12,14,25H,1-2,7-11,15H2,(H,27,30)
KEGG

UniProtKB/SwissProt

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US Patent
n/an/a 3.92n/an/an/an/an/an/a



Je Il Pharmaceutical Co., Ltd.

US Patent


Assay Description
The tankyrase-1 or tankyrase-2 enzyme inhibitory activities of the compounds of the present invention were assayed in the following manner by use of ...


US Patent US10464919 (2019)

More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 1


(Homo sapiens (Human))
BDBM419844
PNG
(US10464919, Example 182)
Show SMILES Fc1cc(CN2CCN(CC2)c2ccc(nn2)C#N)cc2[nH]c(=O)c3CCCNc3c12
Show InChI InChI=1S/C22H22FN7O/c23-17-10-14(11-18-20(17)21-16(22(31)26-18)2-1-5-25-21)13-29-6-8-30(9-7-29)19-4-3-15(12-24)27-28-19/h3-4,10-11,25H,1-2,5-9,13H2,(H,26,31)
PDB
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UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
GoogleScholar
UniChem
US Patent
n/an/a 4.02n/an/an/an/an/an/a



Je Il Pharmaceutical Co., Ltd.

US Patent


Assay Description
The PARP-1 enzyme inhibitory activities of the compounds of the present invention were assayed in the following manner by use of a kit (cat. 80551) p...


US Patent US10464919 (2019)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TNK1


(Homo sapiens (Human))
BDBM419797
PNG
(US10464919, Example 135)
Show SMILES Clc1cc(ncc1C#N)N1CCN(Cc2ccc3c4NCCCc4c(=O)[nH]c3c2)CC1
Show InChI InChI=1S/C23H23ClN6O/c24-19-11-21(27-13-16(19)12-25)30-8-6-29(7-9-30)14-15-3-4-17-20(10-15)28-23(31)18-2-1-5-26-22(17)18/h3-4,10-11,13,26H,1-2,5-9,14H2,(H,28,31)
KEGG

UniProtKB/SwissProt

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US Patent
n/an/a 4.04n/an/an/an/an/an/a



Je Il Pharmaceutical Co., Ltd.

US Patent


Assay Description
The tankyrase-1 or tankyrase-2 enzyme inhibitory activities of the compounds of the present invention were assayed in the following manner by use of ...


US Patent US10464919 (2019)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TNK1


(Homo sapiens (Human))
BDBM419796
PNG
(US10464919, Example 134)
Show SMILES Clc1cc(N2CCN(Cc3ccc4c5NCCCc5c(=O)[nH]c4c3)CC2)c(cn1)C#N
Show InChI InChI=1S/C23H23ClN6O/c24-21-11-20(16(12-25)13-27-21)30-8-6-29(7-9-30)14-15-3-4-17-19(10-15)28-23(31)18-2-1-5-26-22(17)18/h3-4,10-11,13,26H,1-2,5-9,14H2,(H,28,31)
KEGG

UniProtKB/SwissProt

GoogleScholar
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US Patent
n/an/a 4.15n/an/an/an/an/an/a



Je Il Pharmaceutical Co., Ltd.

US Patent


Assay Description
The tankyrase-1 or tankyrase-2 enzyme inhibitory activities of the compounds of the present invention were assayed in the following manner by use of ...


US Patent US10464919 (2019)

More data for this
Ligand-Target Pair
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