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Patent code US10464928

Compile Data Set for Download or QSAR
Found 3 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Amine oxidase, copper containing


(Homo sapiens (Human))
BDBM385387
PNG
((E)-3-Fluoro-2-[[2-(4-methoxy-1-piperidyl)pyrimidi...)
Show SMILES COC1CCN(CC1)c1ncc(OC\C(CN)=C\F)cn1
Show InChI InChI=1S/C14H21FN4O2/c1-20-12-2-4-19(5-3-12)14-17-8-13(9-18-14)21-10-11(6-15)7-16/h6,8-9,12H,2-5,7,10,16H2,1H3/b11-6+
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 12n/an/an/an/an/an/a



Eli Lilly and Company

US Patent


Assay Description
Amine oxidase activity of recombinant SSAO, MAOa, and MAOb isoforms are measured using the MAO-Glo™ assay kit from Promega (V1402). Test compounds (w...


US Patent US10464928 (2019)

More data for this
Ligand-Target Pair
Amine oxidase, copper containing


(Homo sapiens (Human))
BDBM385388
PNG
((E)-3-Fluoro-2-[[2-[(3S)-3-methoxypyrrolidin-1-yl]...)
Show SMILES CO[C@H]1CCN(C1)c1ncc(OC\C(CN)=C\F)cn1
Show InChI InChI=1S/C13H19FN4O2/c1-19-11-2-3-18(8-11)13-16-6-12(7-17-13)20-9-10(4-14)5-15/h4,6-7,11H,2-3,5,8-9,15H2,1H3/b10-4+/t11-/m0/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 32n/an/an/an/an/an/a



Eli Lilly and Company

US Patent


Assay Description
Amine oxidase activity of recombinant SSAO, MAOa, and MAOb isoforms are measured using the MAO-Glo™ assay kit from Promega (V1402). Test compounds (w...


US Patent US10464928 (2019)

More data for this
Ligand-Target Pair
Amine oxidase, copper containing


(Homo sapiens (Human))
BDBM385389
PNG
((3 S)-1-[5-[(E)-2-(Aminomethyl)-3-fluoro-allyloxy]...)
Show SMILES NC\C(COc1cnc(nc1)N1CC[C@H](O)C1)=C/F
Show InChI InChI=1S/C12H17FN4O2/c13-3-9(4-14)8-19-11-5-15-12(16-6-11)17-2-1-10(18)7-17/h3,5-6,10,18H,1-2,4,7-8,14H2/b9-3+/t10-/m0/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 52n/an/an/an/an/an/a



Eli Lilly and Company

US Patent


Assay Description
Amine oxidase activity of recombinant SSAO, MAOa, and MAOb isoforms are measured using the MAO-Glo™ assay kit from Promega (V1402). Test compounds (w...


US Patent US10464928 (2019)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%