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Patent code US10472364

Compile Data Set for Download or QSAR
Found 86 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
5'-nucleotidase


(Homo sapiens (Human))
BDBM420007
PNG
(US10472364, Compound 79)
Show SMILES Nc1nc(Cl)nc2n(cnc12)[C@@H]1O[C@H](COC(Cc2ccc(cc2)-c2ccccc2)(C(O)=O)C(O)=O)[C@@H](O)[C@@H]1F
Show InChI InChI=1S/C26H23ClFN5O7/c27-25-31-20(29)18-21(32-25)33(12-30-18)22-17(28)19(34)16(40-22)11-39-26(23(35)36,24(37)38)10-13-6-8-15(9-7-13)14-4-2-1-3-5-14/h1-9,12,16-17,19,22,34H,10-11H2,(H,35,36)(H,37,38)(H2,29,31,32)/t16-,17+,19-,22-/m1/s1
PDB

UniProtKB/SwissProt

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US Patent
n/an/a 29n/an/an/an/an/an/a



Calithera Biosciences, Inc.

US Patent


Assay Description
For measurements of soluble CD73 enzyme activity, recombinant CD73 was obtained from R&D Systems, Cat. No. 5795-EN-010. Serial dilutions of test comp...


US Patent US10472364 (2019)

More data for this
Ligand-Target Pair
5'-nucleotidase


(Homo sapiens (Human))
BDBM419992
PNG
(US10472364, Compound 65)
Show SMILES Nc1nc(Cl)nc2n(cnc12)[C@@H]1O[C@H](COC(Cc2ccc(OCc3ccccc3)cc2)(C(O)=O)C(O)=O)[C@@H](O)[C@@H]1F
Show InChI InChI=1S/C27H25ClFN5O8/c28-26-32-21(30)19-22(33-26)34(13-31-19)23-18(29)20(35)17(42-23)12-41-27(24(36)37,25(38)39)10-14-6-8-16(9-7-14)40-11-15-4-2-1-3-5-15/h1-9,13,17-18,20,23,35H,10-12H2,(H,36,37)(H,38,39)(H2,30,32,33)/t17-,18+,20-,23-/m1/s1
PDB

UniProtKB/SwissProt

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UniChem
US Patent
n/an/a 31n/an/an/an/an/an/a



Calithera Biosciences, Inc.

US Patent


Assay Description
For measurements of soluble CD73 enzyme activity, recombinant CD73 was obtained from R&D Systems, Cat. No. 5795-EN-010. Serial dilutions of test comp...


US Patent US10472364 (2019)

More data for this
Ligand-Target Pair
5'-nucleotidase


(Homo sapiens (Human))
BDBM419981
PNG
(US10472364, Compound 58)
Show SMILES Nc1nc(Cl)nc2n(cnc12)[C@@H]1O[C@H](COC(Cc2ccc(C(O)=O)c(F)c2)(C(O)=O)C(O)=O)[C@@H](O)[C@@H]1F
Show InChI InChI=1S/C21H18ClF2N5O9/c22-20-27-14(25)12-15(28-20)29(6-26-12)16-11(24)13(30)10(38-16)5-37-21(18(33)34,19(35)36)4-7-1-2-8(17(31)32)9(23)3-7/h1-3,6,10-11,13,16,30H,4-5H2,(H,31,32)(H,33,34)(H,35,36)(H2,25,27,28)/t10-,11+,13-,16-/m1/s1
PDB

UniProtKB/SwissProt

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UniChem
US Patent
n/an/a 38n/an/an/an/an/an/a



Calithera Biosciences, Inc.

US Patent


Assay Description
For measurements of soluble CD73 enzyme activity, recombinant CD73 was obtained from R&D Systems, Cat. No. 5795-EN-010. Serial dilutions of test comp...


US Patent US10472364 (2019)

More data for this
Ligand-Target Pair
5'-nucleotidase


(Homo sapiens (Human))
BDBM420019
PNG
(US10472364, Compound 89)
Show SMILES Nc1nc(Cl)nc2n(cnc12)[C@@H]1O[C@H](COC(Cc2ccc(OCC(F)(F)F)cc2)(C(O)=O)C(O)=O)[C@@H](O)[C@@H]1F
Show InChI InChI=1S/C22H20ClF4N5O8/c23-20-30-15(28)13-16(31-20)32(8-29-13)17-12(24)14(33)11(40-17)6-39-21(18(34)35,19(36)37)5-9-1-3-10(4-2-9)38-7-22(25,26)27/h1-4,8,11-12,14,17,33H,5-7H2,(H,34,35)(H,36,37)(H2,28,30,31)/t11-,12+,14-,17-/m1/s1
PDB

UniProtKB/SwissProt

GoogleScholar
UniChem
US Patent
n/an/a 43n/an/an/an/an/an/a



Calithera Biosciences, Inc.

US Patent


Assay Description
For measurements of soluble CD73 enzyme activity, recombinant CD73 was obtained from R&D Systems, Cat. No. 5795-EN-010. Serial dilutions of test comp...


US Patent US10472364 (2019)

More data for this
Ligand-Target Pair
5'-nucleotidase


(Homo sapiens (Human))
BDBM420009
PNG
(US10472364, Compound 80)
Show SMILES Nc1nc(Cl)nc2n(cnc12)[C@@H]1O[C@H](COC(Cc2ccc(Cl)cc2F)(C(O)=O)C(O)=O)[C@@H](O)[C@@H]1F
Show InChI InChI=1S/C20H17Cl2F2N5O7/c21-8-2-1-7(9(23)3-8)4-20(17(31)32,18(33)34)35-5-10-13(30)11(24)16(36-10)29-6-26-12-14(25)27-19(22)28-15(12)29/h1-3,6,10-11,13,16,30H,4-5H2,(H,31,32)(H,33,34)(H2,25,27,28)/t10-,11+,13-,16-/m1/s1
PDB

UniProtKB/SwissProt

GoogleScholar
UniChem
US Patent
n/an/a 44n/an/an/an/an/an/a



Calithera Biosciences, Inc.

US Patent


Assay Description
For measurements of soluble CD73 enzyme activity, recombinant CD73 was obtained from R&D Systems, Cat. No. 5795-EN-010. Serial dilutions of test comp...


US Patent US10472364 (2019)

More data for this
Ligand-Target Pair
5'-nucleotidase


(Homo sapiens (Human))
BDBM419984
PNG
(US10472364, Compound 60)
Show SMILES Nc1nc(Cl)nc2n(cnc12)[C@@H]1O[C@H](COC(Cc2ccc(c(F)c2)C(F)(F)F)(C(O)=O)C(O)=O)[C@@H](O)[C@@H]1F
Show InChI InChI=1S/C21H17ClF5N5O7/c22-19-30-14(28)12-15(31-19)32(6-29-12)16-11(24)13(33)10(39-16)5-38-20(17(34)35,18(36)37)4-7-1-2-8(9(23)3-7)21(25,26)27/h1-3,6,10-11,13,16,33H,4-5H2,(H,34,35)(H,36,37)(H2,28,30,31)/t10-,11+,13-,16-/m1/s1
PDB

UniProtKB/SwissProt

GoogleScholar
UniChem
US Patent
n/an/a 51n/an/an/an/an/an/a



Calithera Biosciences, Inc.

US Patent


Assay Description
For measurements of soluble CD73 enzyme activity, recombinant CD73 was obtained from R&D Systems, Cat. No. 5795-EN-010. Serial dilutions of test comp...


US Patent US10472364 (2019)

More data for this
Ligand-Target Pair
5'-nucleotidase


(Homo sapiens (Human))
BDBM419950
PNG
(US10472364, Compound 36)
Show SMILES Nc1nc(Cl)nc2n(cnc12)[C@@H]1O[C@H](COC(Cc2ccc(OC(F)(F)F)cc2)(C(O)=O)C(O)=O)[C@@H](O)[C@@H]1F
Show InChI InChI=1S/C21H18ClF4N5O8/c22-19-29-14(27)12-15(30-19)31(7-28-12)16-11(23)13(32)10(38-16)6-37-20(17(33)34,18(35)36)5-8-1-3-9(4-2-8)39-21(24,25)26/h1-4,7,10-11,13,16,32H,5-6H2,(H,33,34)(H,35,36)(H2,27,29,30)/t10-,11+,13-,16-/m1/s1
PDB

UniProtKB/SwissProt

GoogleScholar
UniChem
US Patent
n/an/a 57n/an/an/an/an/an/a



Calithera Biosciences, Inc.

US Patent


Assay Description
For measurements of soluble CD73 enzyme activity, recombinant CD73 was obtained from R&D Systems, Cat. No. 5795-EN-010. Serial dilutions of test comp...


US Patent US10472364 (2019)

More data for this
Ligand-Target Pair
5'-nucleotidase


(Homo sapiens (Human))
BDBM420016
PNG
(US10472364, Compound 86)
Show SMILES Nc1nc(Cl)nc2n(cnc12)[C@@H]1O[C@H](COC(Cc2ccc(cc2)S(N)(=O)=O)(C(O)=O)C(O)=O)[C@@H](O)[C@@H]1F
Show InChI InChI=1S/C20H20ClFN6O9S/c21-19-26-14(23)12-15(27-19)28(7-25-12)16-11(22)13(29)10(37-16)6-36-20(17(30)31,18(32)33)5-8-1-3-9(4-2-8)38(24,34)35/h1-4,7,10-11,13,16,29H,5-6H2,(H,30,31)(H,32,33)(H2,23,26,27)(H2,24,34,35)/t10-,11+,13-,16-/m1/s1
PDB

UniProtKB/SwissProt

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UniChem
US Patent
n/an/a 62n/an/an/an/an/an/a



Calithera Biosciences, Inc.

US Patent


Assay Description
For measurements of soluble CD73 enzyme activity, recombinant CD73 was obtained from R&D Systems, Cat. No. 5795-EN-010. Serial dilutions of test comp...


US Patent US10472364 (2019)

More data for this
Ligand-Target Pair
5'-nucleotidase


(Homo sapiens (Human))
BDBM420003
PNG
(US10472364, Compound 76)
Show SMILES Nc1nc(Cl)nc2n(cnc12)[C@@H]1O[C@H](COC(Cc2csc(c2)C(O)=O)(C(O)=O)C(O)=O)[C@@H](O)[C@@H]1F
Show InChI InChI=1S/C19H17ClFN5O9S/c20-18-24-12(22)10-13(25-18)26(5-23-10)14-9(21)11(27)7(35-14)3-34-19(16(30)31,17(32)33)2-6-1-8(15(28)29)36-4-6/h1,4-5,7,9,11,14,27H,2-3H2,(H,28,29)(H,30,31)(H,32,33)(H2,22,24,25)/t7-,9+,11-,14-/m1/s1
PDB

UniProtKB/SwissProt

GoogleScholar
UniChem
US Patent
n/an/a 74n/an/an/an/an/an/a



Calithera Biosciences, Inc.

US Patent


Assay Description
For measurements of soluble CD73 enzyme activity, recombinant CD73 was obtained from R&D Systems, Cat. No. 5795-EN-010. Serial dilutions of test comp...


US Patent US10472364 (2019)

More data for this
Ligand-Target Pair
5'-nucleotidase


(Homo sapiens (Human))
BDBM420017
PNG
(US10472364, Compound 87)
Show SMILES Nc1nc(Cl)nc2n(cnc12)[C@@H]1O[C@H](COC(Cc2ccc(cc2)C(=O)NCCC(O)=O)(C(O)=O)C(O)=O)[C@@H](O)[C@@H]1F
Show InChI InChI=1S/C24H24ClFN6O10/c25-23-30-17(27)15-18(31-23)32(9-29-15)20-14(26)16(35)12(42-20)8-41-24(21(37)38,22(39)40)7-10-1-3-11(4-2-10)19(36)28-6-5-13(33)34/h1-4,9,12,14,16,20,35H,5-8H2,(H,28,36)(H,33,34)(H,37,38)(H,39,40)(H2,27,30,31)/t12-,14+,16-,20-/m1/s1
PDB

UniProtKB/SwissProt

GoogleScholar
UniChem
US Patent
n/an/a 83n/an/an/an/an/an/a



Calithera Biosciences, Inc.

US Patent


Assay Description
For measurements of soluble CD73 enzyme activity, recombinant CD73 was obtained from R&D Systems, Cat. No. 5795-EN-010. Serial dilutions of test comp...


US Patent US10472364 (2019)

More data for this
Ligand-Target Pair
5'-nucleotidase


(Homo sapiens (Human))
BDBM420006
PNG
(US10472364, Compound 78)
Show SMILES Nc1nc(Cl)nc2n(cnc12)[C@@H]1O[C@H](COC(Cc2ccc(CC(O)=O)cc2)(C(O)=O)C(O)=O)[C@@H](O)[C@@H]1F
Show InChI InChI=1S/C22H21ClFN5O9/c23-21-27-16(25)14-17(28-21)29(8-26-14)18-13(24)15(32)11(38-18)7-37-22(19(33)34,20(35)36)6-10-3-1-9(2-4-10)5-12(30)31/h1-4,8,11,13,15,18,32H,5-7H2,(H,30,31)(H,33,34)(H,35,36)(H2,25,27,28)/t11-,13+,15-,18-/m1/s1
PDB

UniProtKB/SwissProt

GoogleScholar
KEGG
UniChem
US Patent
n/an/a 86n/an/an/an/an/an/a



Calithera Biosciences, Inc.

US Patent


Assay Description
For measurements of soluble CD73 enzyme activity, recombinant CD73 was obtained from R&D Systems, Cat. No. 5795-EN-010. Serial dilutions of test comp...


US Patent US10472364 (2019)

More data for this
Ligand-Target Pair
5'-nucleotidase


(Homo sapiens (Human))
BDBM419948
PNG
(US10472364, Compound 34)
Show SMILES Nc1nc(Cl)nc2n(cnc12)[C@@H]1O[C@H](COC(Cc2ccc(cc2)C#N)(C(O)=O)C(O)=O)[C@@H](O)[C@@H]1F
Show InChI InChI=1S/C21H18ClFN6O7/c22-20-27-15(25)13-16(28-20)29(8-26-13)17-12(23)14(30)11(36-17)7-35-21(18(31)32,19(33)34)5-9-1-3-10(6-24)4-2-9/h1-4,8,11-12,14,17,30H,5,7H2,(H,31,32)(H,33,34)(H2,25,27,28)/t11-,12+,14-,17-/m1/s1
PDB

UniProtKB/SwissProt

GoogleScholar
UniChem
US Patent
n/an/a 97n/an/an/an/an/an/a



Calithera Biosciences, Inc.

US Patent


Assay Description
For measurements of soluble CD73 enzyme activity, recombinant CD73 was obtained from R&D Systems, Cat. No. 5795-EN-010. Serial dilutions of test comp...


US Patent US10472364 (2019)

More data for this
Ligand-Target Pair
5'-nucleotidase


(Homo sapiens (Human))
BDBM420023
PNG
(US10472364, Compound 95)
Show SMILES Nc1nc(Cl)nc2n(cnc12)[C@@H]1O[C@H](COC(Cc2ccc(cc2)-c2ccccc2C#N)(C(O)=O)C(O)=O)[C@@H](O)[C@@H]1F
Show InChI InChI=1S/C27H22ClFN6O7/c28-26-33-21(31)19-22(34-26)35(12-32-19)23-18(29)20(36)17(42-23)11-41-27(24(37)38,25(39)40)9-13-5-7-14(8-6-13)16-4-2-1-3-15(16)10-30/h1-8,12,17-18,20,23,36H,9,11H2,(H,37,38)(H,39,40)(H2,31,33,34)/t17-,18+,20-,23-/m1/s1
PDB

UniProtKB/SwissProt

GoogleScholar
UniChem
US Patent
n/an/a 105n/an/an/an/an/an/a



Calithera Biosciences, Inc.

US Patent


Assay Description
For measurements of soluble CD73 enzyme activity, recombinant CD73 was obtained from R&D Systems, Cat. No. 5795-EN-010. Serial dilutions of test comp...


US Patent US10472364 (2019)

More data for this
Ligand-Target Pair
5'-nucleotidase


(Homo sapiens (Human))
BDBM419934
PNG
(US10472364, Compound 20)
Show SMILES Nc1nc(Cl)nc2n(cnc12)[C@@H]1O[C@H](COC(Cc2ccc(cc2)C(F)(F)F)(C(O)=O)C(O)=O)[C@@H](O)[C@@H]1F
Show InChI InChI=1S/C21H18ClF4N5O7/c22-19-29-14(27)12-15(30-19)31(7-28-12)16-11(23)13(32)10(38-16)6-37-20(17(33)34,18(35)36)5-8-1-3-9(4-2-8)21(24,25)26/h1-4,7,10-11,13,16,32H,5-6H2,(H,33,34)(H,35,36)(H2,27,29,30)/t10-,11+,13-,16-/m1/s1
PDB

UniProtKB/SwissProt

GoogleScholar
UniChem
US Patent
n/an/a 109n/an/an/an/an/an/a



Calithera Biosciences, Inc.

US Patent


Assay Description
For measurements of soluble CD73 enzyme activity, recombinant CD73 was obtained from R&D Systems, Cat. No. 5795-EN-010. Serial dilutions of test comp...


US Patent US10472364 (2019)

More data for this
Ligand-Target Pair
5'-nucleotidase


(Homo sapiens (Human))
BDBM419960
PNG
(US10472364, Compound 42)
Show SMILES Nc1nc(Cl)nc2n(cnc12)[C@@H]1O[C@H](COC(Cc2cccc(c2)C(O)=O)(C(O)=O)C(O)=O)[C@@H](O)[C@@H]1F
Show InChI InChI=1S/C21H19ClFN5O9/c22-20-26-14(24)12-15(27-20)28(7-25-12)16-11(23)13(29)10(37-16)6-36-21(18(32)33,19(34)35)5-8-2-1-3-9(4-8)17(30)31/h1-4,7,10-11,13,16,29H,5-6H2,(H,30,31)(H,32,33)(H,34,35)(H2,24,26,27)/t10-,11+,13-,16-/m1/s1
PDB

UniProtKB/SwissProt

GoogleScholar
UniChem
US Patent
n/an/a 119n/an/an/an/an/an/a



Calithera Biosciences, Inc.

US Patent


Assay Description
For measurements of soluble CD73 enzyme activity, recombinant CD73 was obtained from R&D Systems, Cat. No. 5795-EN-010. Serial dilutions of test comp...


US Patent US10472364 (2019)

More data for this
Ligand-Target Pair
5'-nucleotidase


(Homo sapiens (Human))
BDBM419920
PNG
(US10472364, Compound 6 | US10472364, Compound 7)
Show SMILES Nc1nc(Cl)nc2n(cnc12)[C@@H]1O[C@H](COC(Cc2ccccc2)(C(O)=O)C(O)=O)[C@@H](O)[C@@H]1F
Show InChI InChI=1S/C20H19ClFN5O7/c21-19-25-14(23)12-15(26-19)27(8-24-12)16-11(22)13(28)10(34-16)7-33-20(17(29)30,18(31)32)6-9-4-2-1-3-5-9/h1-5,8,10-11,13,16,28H,6-7H2,(H,29,30)(H,31,32)(H2,23,25,26)/t10-,11+,13-,16-/m1/s1
PDB

UniProtKB/SwissProt

GoogleScholar
UniChem
US Patent
n/an/a 121n/an/an/an/an/an/a



Calithera Biosciences, Inc.

US Patent


Assay Description
For measurements of soluble CD73 enzyme activity, recombinant CD73 was obtained from R&D Systems, Cat. No. 5795-EN-010. Serial dilutions of test comp...


US Patent US10472364 (2019)

More data for this
Ligand-Target Pair
5'-nucleotidase


(Homo sapiens (Human))
BDBM419920
PNG
(US10472364, Compound 6 | US10472364, Compound 7)
Show SMILES Nc1nc(Cl)nc2n(cnc12)[C@@H]1O[C@H](COC(Cc2ccccc2)(C(O)=O)C(O)=O)[C@@H](O)[C@@H]1F
Show InChI InChI=1S/C20H19ClFN5O7/c21-19-25-14(23)12-15(26-19)27(8-24-12)16-11(22)13(28)10(34-16)7-33-20(17(29)30,18(31)32)6-9-4-2-1-3-5-9/h1-5,8,10-11,13,16,28H,6-7H2,(H,29,30)(H,31,32)(H2,23,25,26)/t10-,11+,13-,16-/m1/s1
PDB

UniProtKB/SwissProt

GoogleScholar
UniChem
US Patent
n/an/a 130n/an/an/an/an/an/a



Calithera Biosciences, Inc.

US Patent


Assay Description
For measurements of soluble CD73 enzyme activity, recombinant CD73 was obtained from R&D Systems, Cat. No. 5795-EN-010. Serial dilutions of test comp...


US Patent US10472364 (2019)

More data for this
Ligand-Target Pair
5'-nucleotidase


(Homo sapiens (Human))
BDBM419993
PNG
(US10472364, Compound 66)
Show SMILES Nc1nc(Cl)nc2n(cnc12)[C@@H]1O[C@H](COC(Cc2ccc(O)cc2)(C(O)=O)C(O)=O)[C@@H](O)[C@@H]1F
Show InChI InChI=1S/C20H19ClFN5O8/c21-19-25-14(23)12-15(26-19)27(7-24-12)16-11(22)13(29)10(35-16)6-34-20(17(30)31,18(32)33)5-8-1-3-9(28)4-2-8/h1-4,7,10-11,13,16,28-29H,5-6H2,(H,30,31)(H,32,33)(H2,23,25,26)/t10-,11+,13-,16-/m1/s1
PDB

UniProtKB/SwissProt

GoogleScholar
UniChem
US Patent
n/an/a 133n/an/an/an/an/an/a



Calithera Biosciences, Inc.

US Patent


Assay Description
For measurements of soluble CD73 enzyme activity, recombinant CD73 was obtained from R&D Systems, Cat. No. 5795-EN-010. Serial dilutions of test comp...


US Patent US10472364 (2019)

More data for this
Ligand-Target Pair
5'-nucleotidase


(Homo sapiens (Human))
BDBM419979
PNG
(US10472364, Compound 57)
Show SMILES Nc1nc(Cl)nc2n(cnc12)[C@@H]1O[C@H](COC(Cc2ccc(cc2F)C(O)=O)(C(O)=O)C(O)=O)[C@@H](O)[C@@H]1F
Show InChI InChI=1S/C21H18ClF2N5O9/c22-20-27-14(25)12-15(28-20)29(6-26-12)16-11(24)13(30)10(38-16)5-37-21(18(33)34,19(35)36)4-8-2-1-7(17(31)32)3-9(8)23/h1-3,6,10-11,13,16,30H,4-5H2,(H,31,32)(H,33,34)(H,35,36)(H2,25,27,28)/t10-,11+,13-,16-/m1/s1
PDB

UniProtKB/SwissProt

GoogleScholar
UniChem
US Patent
n/an/a 142n/an/an/an/an/an/a



Calithera Biosciences, Inc.

US Patent


Assay Description
For measurements of soluble CD73 enzyme activity, recombinant CD73 was obtained from R&D Systems, Cat. No. 5795-EN-010. Serial dilutions of test comp...


US Patent US10472364 (2019)

More data for this
Ligand-Target Pair
5'-nucleotidase


(Homo sapiens (Human))
BDBM419953
PNG
(US10472364, Compound 39)
Show SMILES Nc1nc(Cl)nc2n(cnc12)[C@@H]1O[C@H](COC(Cc2ccc(CO)cc2)(C(O)=O)C(O)=O)[C@@H](O)[C@@H]1F
Show InChI InChI=1S/C21H21ClFN5O8/c22-20-26-15(24)13-16(27-20)28(8-25-13)17-12(23)14(30)11(36-17)7-35-21(18(31)32,19(33)34)5-9-1-3-10(6-29)4-2-9/h1-4,8,11-12,14,17,29-30H,5-7H2,(H,31,32)(H,33,34)(H2,24,26,27)/t11-,12+,14-,17-/m1/s1
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n/an/a 160n/an/an/an/an/an/a



Calithera Biosciences, Inc.

US Patent


Assay Description
For measurements of soluble CD73 enzyme activity, recombinant CD73 was obtained from R&D Systems, Cat. No. 5795-EN-010. Serial dilutions of test comp...


US Patent US10472364 (2019)

More data for this
Ligand-Target Pair
5'-nucleotidase


(Homo sapiens (Human))
BDBM419977
PNG
(US10472364, Compound 56)
Show SMILES Nc1nc(Cl)nc2n(cnc12)[C@@H]1O[C@H](COC(Cc2cccc(O)c2)(C(O)=O)C(O)=O)[C@@H](O)[C@@H]1F
Show InChI InChI=1S/C20H19ClFN5O8/c21-19-25-14(23)12-15(26-19)27(7-24-12)16-11(22)13(29)10(35-16)6-34-20(17(30)31,18(32)33)5-8-2-1-3-9(28)4-8/h1-4,7,10-11,13,16,28-29H,5-6H2,(H,30,31)(H,32,33)(H2,23,25,26)/t10-,11+,13-,16-/m1/s1
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n/an/a 168n/an/an/an/an/an/a



Calithera Biosciences, Inc.

US Patent


Assay Description
For measurements of soluble CD73 enzyme activity, recombinant CD73 was obtained from R&D Systems, Cat. No. 5795-EN-010. Serial dilutions of test comp...


US Patent US10472364 (2019)

More data for this
Ligand-Target Pair
5'-nucleotidase


(Homo sapiens (Human))
BDBM420021
PNG
(US10472364, Compound 92)
Show SMILES Nc1nc(Cl)nc2n(cnc12)[C@@H]1O[C@H](COC(Cc2ccc(OCC(O)=O)cc2)(C(O)=O)C(O)=O)[C@@H](O)[C@@H]1F
Show InChI InChI=1S/C22H21ClFN5O10/c23-21-27-16(25)14-17(28-21)29(8-26-14)18-13(24)15(32)11(39-18)6-38-22(19(33)34,20(35)36)5-9-1-3-10(4-2-9)37-7-12(30)31/h1-4,8,11,13,15,18,32H,5-7H2,(H,30,31)(H,33,34)(H,35,36)(H2,25,27,28)/t11-,13+,15-,18-/m1/s1
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n/an/a 172n/an/an/an/an/an/a



Calithera Biosciences, Inc.

US Patent


Assay Description
For measurements of soluble CD73 enzyme activity, recombinant CD73 was obtained from R&D Systems, Cat. No. 5795-EN-010. Serial dilutions of test comp...


US Patent US10472364 (2019)

More data for this
Ligand-Target Pair
5'-nucleotidase


(Homo sapiens (Human))
BDBM420015
PNG
(US10472364, Compound 85)
Show SMILES COc1ccc(CC(OC[C@H]2O[C@H]([C@@H](F)[C@@H]2O)n2cnc3c(N)nc(Cl)nc23)(C(O)=O)C(O)=O)cc1Cl
Show InChI InChI=1S/C21H20Cl2FN5O8/c1-35-10-3-2-8(4-9(10)22)5-21(18(31)32,19(33)34)36-6-11-14(30)12(24)17(37-11)29-7-26-13-15(25)27-20(23)28-16(13)29/h2-4,7,11-12,14,17,30H,5-6H2,1H3,(H,31,32)(H,33,34)(H2,25,27,28)/t11-,12+,14-,17-/m1/s1
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n/an/a 183n/an/an/an/an/an/a



Calithera Biosciences, Inc.

US Patent


Assay Description
For measurements of soluble CD73 enzyme activity, recombinant CD73 was obtained from R&D Systems, Cat. No. 5795-EN-010. Serial dilutions of test comp...


US Patent US10472364 (2019)

More data for this
Ligand-Target Pair
5'-nucleotidase


(Homo sapiens (Human))
BDBM419935
PNG
(US10472364, Compound 21)
Show SMILES CS(=O)(=O)c1ccc(CC(OC[C@H]2O[C@H]([C@@H](F)[C@@H]2O)n2cnc3c(N)nc(Cl)nc23)(C(O)=O)C(O)=O)cc1
Show InChI InChI=1S/C21H21ClFN5O9S/c1-38(34,35)10-4-2-9(3-5-10)6-21(18(30)31,19(32)33)36-7-11-14(29)12(23)17(37-11)28-8-25-13-15(24)26-20(22)27-16(13)28/h2-5,8,11-12,14,17,29H,6-7H2,1H3,(H,30,31)(H,32,33)(H2,24,26,27)/t11-,12+,14-,17-/m1/s1
PDB

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n/an/a 193n/an/an/an/an/an/a



Calithera Biosciences, Inc.

US Patent


Assay Description
For measurements of soluble CD73 enzyme activity, recombinant CD73 was obtained from R&D Systems, Cat. No. 5795-EN-010. Serial dilutions of test comp...


US Patent US10472364 (2019)

More data for this
Ligand-Target Pair
5'-nucleotidase


(Homo sapiens (Human))
BDBM419965
PNG
(US10472364, Compound 32)
Show SMILES Nc1nc(Cl)nc2n(cnc12)[C@@H]1O[C@H](COC(Cc2ccc(nc2)C(F)(F)F)(C(O)=O)C(O)=O)[C@@H](O)[C@@H]1F
Show InChI InChI=1S/C20H17ClF4N6O7/c21-18-29-13(26)11-14(30-18)31(6-28-11)15-10(22)12(32)8(38-15)5-37-19(16(33)34,17(35)36)3-7-1-2-9(27-4-7)20(23,24)25/h1-2,4,6,8,10,12,15,32H,3,5H2,(H,33,34)(H,35,36)(H2,26,29,30)/t8-,10+,12-,15-/m1/s1
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n/an/a 199n/an/an/an/an/an/a



Calithera Biosciences, Inc.

US Patent


Assay Description
For measurements of soluble CD73 enzyme activity, recombinant CD73 was obtained from R&D Systems, Cat. No. 5795-EN-010. Serial dilutions of test comp...


US Patent US10472364 (2019)

More data for this
Ligand-Target Pair
5'-nucleotidase


(Homo sapiens (Human))
BDBM419938
PNG
(US10472364, Compound 23)
Show SMILES Nc1nc(Cl)nc2n(cnc12)[C@@H]1O[C@H](COC(Cc2ccsc2)(C(O)=O)C(O)=O)[C@@H](O)[C@@H]1F
Show InChI InChI=1S/C18H17ClFN5O7S/c19-17-23-12(21)10-13(24-17)25(6-22-10)14-9(20)11(26)8(32-14)4-31-18(15(27)28,16(29)30)3-7-1-2-33-5-7/h1-2,5-6,8-9,11,14,26H,3-4H2,(H,27,28)(H,29,30)(H2,21,23,24)/t8-,9+,11-,14-/m1/s1
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n/an/a 206n/an/an/an/an/an/a



Calithera Biosciences, Inc.

US Patent


Assay Description
For measurements of soluble CD73 enzyme activity, recombinant CD73 was obtained from R&D Systems, Cat. No. 5795-EN-010. Serial dilutions of test comp...


US Patent US10472364 (2019)

More data for this
Ligand-Target Pair
5'-nucleotidase


(Homo sapiens (Human))
BDBM419941
PNG
(US10472364, Compound 27)
Show SMILES Nc1cccc(CC(OC[C@H]2O[C@H]([C@@H](F)[C@@H]2O)n2cnc3c(N)nc(Cl)nc23)(C(O)=O)C(O)=O)c1
Show InChI InChI=1S/C20H20ClFN6O7/c21-19-26-14(24)12-15(27-19)28(7-25-12)16-11(22)13(29)10(35-16)6-34-20(17(30)31,18(32)33)5-8-2-1-3-9(23)4-8/h1-4,7,10-11,13,16,29H,5-6,23H2,(H,30,31)(H,32,33)(H2,24,26,27)/t10-,11+,13-,16-/m1/s1
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n/an/a 218n/an/an/an/an/an/a



Calithera Biosciences, Inc.

US Patent


Assay Description
For measurements of soluble CD73 enzyme activity, recombinant CD73 was obtained from R&D Systems, Cat. No. 5795-EN-010. Serial dilutions of test comp...


US Patent US10472364 (2019)

More data for this
Ligand-Target Pair
5'-nucleotidase


(Homo sapiens (Human))
BDBM419973
PNG
(US10472364, Compound 54)
Show SMILES Nc1nc(Cl)nc2n(cnc12)[C@@H]1O[C@H](COC(Cc2ccc(cc2)-c2nnn[nH]2)(C(O)=O)C(O)=O)[C@@H](O)[C@@H]1F
Show InChI InChI=1/C21H19ClFN9O7/c22-20-26-14(24)12-16(27-20)32(7-25-12)17-11(23)13(33)10(39-17)6-38-21(18(34)35,19(36)37)5-8-1-3-9(4-2-8)15-28-30-31-29-15/h1-4,7,10-11,13,17,33H,5-6H2,(H,34,35)(H,36,37)(H2,24,26,27)(H,28,29,30,31)/t10-,11+,13-,17-/s2
PDB

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n/an/a 220n/an/an/an/an/an/a



Calithera Biosciences, Inc.

US Patent


Assay Description
For measurements of soluble CD73 enzyme activity, recombinant CD73 was obtained from R&D Systems, Cat. No. 5795-EN-010. Serial dilutions of test comp...


US Patent US10472364 (2019)

More data for this
Ligand-Target Pair
5'-nucleotidase


(Homo sapiens (Human))
BDBM420018
PNG
(US10472364, Compound 88)
Show SMILES Nc1nc(Cl)nc2n(cnc12)[C@@H]1O[C@H](COC(Cc2ccc3oc(cc3c2)C(O)=O)(C(O)=O)C(O)=O)[C@@H](O)[C@@H]1F
Show InChI InChI=1S/C23H19ClFN5O10/c24-22-28-16(26)14-17(29-22)30(7-27-14)18-13(25)15(31)12(40-18)6-38-23(20(34)35,21(36)37)5-8-1-2-10-9(3-8)4-11(39-10)19(32)33/h1-4,7,12-13,15,18,31H,5-6H2,(H,32,33)(H,34,35)(H,36,37)(H2,26,28,29)/t12-,13+,15-,18-/m1/s1
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n/an/a 238n/an/an/an/an/an/a



Calithera Biosciences, Inc.

US Patent


Assay Description
For measurements of soluble CD73 enzyme activity, recombinant CD73 was obtained from R&D Systems, Cat. No. 5795-EN-010. Serial dilutions of test comp...


US Patent US10472364 (2019)

More data for this
Ligand-Target Pair
5'-nucleotidase


(Homo sapiens (Human))
BDBM420004
PNG
(US10472364, Compound 77)
Show SMILES Nc1nc(Cl)nc2n(cnc12)[C@@H]1O[C@H](COC(Cc2ccc(s2)C(O)=O)(C(O)=O)C(O)=O)[C@@H](O)[C@@H]1F
Show InChI InChI=1S/C19H17ClFN5O9S/c20-18-24-12(22)10-13(25-18)26(5-23-10)14-9(21)11(27)7(35-14)4-34-19(16(30)31,17(32)33)3-6-1-2-8(36-6)15(28)29/h1-2,5,7,9,11,14,27H,3-4H2,(H,28,29)(H,30,31)(H,32,33)(H2,22,24,25)/t7-,9+,11-,14-/m1/s1
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n/an/a 255n/an/an/an/an/an/a



Calithera Biosciences, Inc.

US Patent


Assay Description
For measurements of soluble CD73 enzyme activity, recombinant CD73 was obtained from R&D Systems, Cat. No. 5795-EN-010. Serial dilutions of test comp...


US Patent US10472364 (2019)

More data for this
Ligand-Target Pair
5'-nucleotidase


(Homo sapiens (Human))
BDBM419929
PNG
(US10472364, Compound 16)
Show SMILES Nc1nc(Cl)nc2n(cnc12)[C@@H]1O[C@H](COC(Cc2cccc(c2)C(F)(F)F)(C(O)=O)C(O)=O)[C@@H](O)[C@@H]1F
Show InChI InChI=1S/C21H18ClF4N5O7/c22-19-29-14(27)12-15(30-19)31(7-28-12)16-11(23)13(32)10(38-16)6-37-20(17(33)34,18(35)36)5-8-2-1-3-9(4-8)21(24,25)26/h1-4,7,10-11,13,16,32H,5-6H2,(H,33,34)(H,35,36)(H2,27,29,30)/t10-,11+,13-,16-/m1/s1
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n/an/a 257n/an/an/an/an/an/a



Calithera Biosciences, Inc.

US Patent


Assay Description
For measurements of soluble CD73 enzyme activity, recombinant CD73 was obtained from R&D Systems, Cat. No. 5795-EN-010. Serial dilutions of test comp...


US Patent US10472364 (2019)

More data for this
Ligand-Target Pair
5'-nucleotidase


(Homo sapiens (Human))
BDBM419962
PNG
(US10472364, Compound 44)
Show SMILES Nc1nc(Cl)nc2n(cnc12)[C@@H]1O[C@H](COC(Cc2cccc(F)c2)(C(O)=O)C(O)=O)[C@@H](O)[C@@H]1F
Show InChI InChI=1S/C20H18ClF2N5O7/c21-19-26-14(24)12-15(27-19)28(7-25-12)16-11(23)13(29)10(35-16)6-34-20(17(30)31,18(32)33)5-8-2-1-3-9(22)4-8/h1-4,7,10-11,13,16,29H,5-6H2,(H,30,31)(H,32,33)(H2,24,26,27)/t10-,11+,13-,16-/m1/s1
PDB

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n/an/a 273n/an/an/an/an/an/a



Calithera Biosciences, Inc.

US Patent


Assay Description
For measurements of soluble CD73 enzyme activity, recombinant CD73 was obtained from R&D Systems, Cat. No. 5795-EN-010. Serial dilutions of test comp...


US Patent US10472364 (2019)

More data for this
Ligand-Target Pair
5'-nucleotidase


(Homo sapiens (Human))
BDBM419928
PNG
(US10472364, Compound 15)
Show SMILES Nc1nc(Cl)nc2n(cnc12)[C@@H]1O[C@H](COC(Cc2cccc(OC(F)(F)F)c2)(C(O)=O)C(O)=O)[C@@H](O)[C@@H]1F
Show InChI InChI=1S/C21H18ClF4N5O8/c22-19-29-14(27)12-15(30-19)31(7-28-12)16-11(23)13(32)10(38-16)6-37-20(17(33)34,18(35)36)5-8-2-1-3-9(4-8)39-21(24,25)26/h1-4,7,10-11,13,16,32H,5-6H2,(H,33,34)(H,35,36)(H2,27,29,30)/t10-,11+,13-,16-/m1/s1
PDB

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n/an/a 308n/an/an/an/an/an/a



Calithera Biosciences, Inc.

US Patent


Assay Description
For measurements of soluble CD73 enzyme activity, recombinant CD73 was obtained from R&D Systems, Cat. No. 5795-EN-010. Serial dilutions of test comp...


US Patent US10472364 (2019)

More data for this
Ligand-Target Pair
5'-nucleotidase


(Homo sapiens (Human))
BDBM420020
PNG
(US10472364, Compound 91)
Show SMILES Cc1ccc(CC(OC[C@H]2O[C@H]([C@@H](F)[C@@H]2O)n2cnc3c(N)nc(Cl)nc23)(C(O)=O)C(O)=O)cc1
Show InChI InChI=1S/C21H21ClFN5O7/c1-9-2-4-10(5-3-9)6-21(18(30)31,19(32)33)34-7-11-14(29)12(23)17(35-11)28-8-25-13-15(24)26-20(22)27-16(13)28/h2-5,8,11-12,14,17,29H,6-7H2,1H3,(H,30,31)(H,32,33)(H2,24,26,27)/t11-,12+,14-,17-/m1/s1
PDB

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n/an/a 322n/an/an/an/an/an/a



Calithera Biosciences, Inc.

US Patent


Assay Description
For measurements of soluble CD73 enzyme activity, recombinant CD73 was obtained from R&D Systems, Cat. No. 5795-EN-010. Serial dilutions of test comp...


US Patent US10472364 (2019)

More data for this
Ligand-Target Pair
5'-nucleotidase


(Homo sapiens (Human))
BDBM419999
PNG
(US10472364, Compound 68)
Show SMILES Nc1nc(Cl)nc2n(cnc12)[C@@H]1O[C@H](COC(Cc2csc(n2)C(O)=O)(C(O)=O)C(O)=O)[C@@H](O)[C@@H]1F
Show InChI InChI=1S/C18H16ClFN6O9S/c19-17-24-10(21)8-11(25-17)26(4-22-8)13-7(20)9(27)6(35-13)2-34-18(15(30)31,16(32)33)1-5-3-36-12(23-5)14(28)29/h3-4,6-7,9,13,27H,1-2H2,(H,28,29)(H,30,31)(H,32,33)(H2,21,24,25)/t6-,7+,9-,13-/m1/s1
PDB

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n/an/a 322n/an/an/an/an/an/a



Calithera Biosciences, Inc.

US Patent


Assay Description
For measurements of soluble CD73 enzyme activity, recombinant CD73 was obtained from R&D Systems, Cat. No. 5795-EN-010. Serial dilutions of test comp...


US Patent US10472364 (2019)

More data for this
Ligand-Target Pair
5'-nucleotidase


(Homo sapiens (Human))
BDBM419963
PNG
(US10472364, Compound 47)
Show SMILES Nc1nc(Cl)nc2n(cnc12)[C@@H]1O[C@H](COC(Cc2ccc(F)cc2)(C(O)=O)C(O)=O)[C@@H](O)[C@@H]1F
Show InChI InChI=1S/C20H18ClF2N5O7/c21-19-26-14(24)12-15(27-19)28(7-25-12)16-11(23)13(29)10(35-16)6-34-20(17(30)31,18(32)33)5-8-1-3-9(22)4-2-8/h1-4,7,10-11,13,16,29H,5-6H2,(H,30,31)(H,32,33)(H2,24,26,27)/t10-,11+,13-,16-/m1/s1
PDB

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n/an/a 343n/an/an/an/an/an/a



Calithera Biosciences, Inc.

US Patent


Assay Description
For measurements of soluble CD73 enzyme activity, recombinant CD73 was obtained from R&D Systems, Cat. No. 5795-EN-010. Serial dilutions of test comp...


US Patent US10472364 (2019)

More data for this
Ligand-Target Pair
5'-nucleotidase


(Homo sapiens (Human))
BDBM419922
PNG
(US10472364, Compound 8)
Show SMILES Nc1nc(Cl)nc2n(cnc12)[C@@H]1O[C@H](COC(Cc2ccc(Cl)nc2)(C(O)=O)C(O)=O)[C@@H](O)[C@@H]1F
Show InChI InChI=1S/C19H17Cl2FN6O7/c20-9-2-1-7(4-24-9)3-19(16(30)31,17(32)33)34-5-8-12(29)10(22)15(35-8)28-6-25-11-13(23)26-18(21)27-14(11)28/h1-2,4,6,8,10,12,15,29H,3,5H2,(H,30,31)(H,32,33)(H2,23,26,27)/t8-,10+,12-,15-/m1/s1
PDB

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n/an/a 363n/an/an/an/an/an/a



Calithera Biosciences, Inc.

US Patent


Assay Description
For measurements of soluble CD73 enzyme activity, recombinant CD73 was obtained from R&D Systems, Cat. No. 5795-EN-010. Serial dilutions of test comp...


US Patent US10472364 (2019)

More data for this
Ligand-Target Pair
5'-nucleotidase


(Homo sapiens (Human))
BDBM419926
PNG
(US10472364, Compound 13)
Show SMILES Nc1nc(Cl)nc2n(cnc12)[C@@H]1O[C@H](COC(Cc2cccc(Oc3ccccc3)c2)(C(O)=O)C(O)=O)[C@@H](O)[C@@H]1F
Show InChI InChI=1S/C26H23ClFN5O8/c27-25-31-20(29)18-21(32-25)33(12-30-18)22-17(28)19(34)16(41-22)11-39-26(23(35)36,24(37)38)10-13-5-4-8-15(9-13)40-14-6-2-1-3-7-14/h1-9,12,16-17,19,22,34H,10-11H2,(H,35,36)(H,37,38)(H2,29,31,32)/t16-,17+,19-,22-/m1/s1
PDB

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n/an/a 403n/an/an/an/an/an/a



Calithera Biosciences, Inc.

US Patent


Assay Description
For measurements of soluble CD73 enzyme activity, recombinant CD73 was obtained from R&D Systems, Cat. No. 5795-EN-010. Serial dilutions of test comp...


US Patent US10472364 (2019)

More data for this
Ligand-Target Pair
5'-nucleotidase


(Homo sapiens (Human))
BDBM419983
PNG
(US10472364, Compound 59)
Show SMILES Nc1nc(Cl)nc2n(cnc12)[C@@H]1O[C@H](COC(Cc2ccc(o2)C(F)(F)F)(C(O)=O)C(O)=O)[C@@H](O)[C@@H]1F
Show InChI InChI=1S/C19H16ClF4N5O8/c20-17-27-12(25)10-13(28-17)29(5-26-10)14-9(21)11(30)7(37-14)4-35-18(15(31)32,16(33)34)3-6-1-2-8(36-6)19(22,23)24/h1-2,5,7,9,11,14,30H,3-4H2,(H,31,32)(H,33,34)(H2,25,27,28)/t7-,9+,11-,14-/m1/s1
PDB

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n/an/a 439n/an/an/an/an/an/a



Calithera Biosciences, Inc.

US Patent


Assay Description
For measurements of soluble CD73 enzyme activity, recombinant CD73 was obtained from R&D Systems, Cat. No. 5795-EN-010. Serial dilutions of test comp...


US Patent US10472364 (2019)

More data for this
Ligand-Target Pair
5'-nucleotidase


(Homo sapiens (Human))
BDBM419972
PNG
(US10472364, Compound 53)
Show SMILES Nc1nc(Cl)nc2n(cnc12)[C@@H]1O[C@H](COC(Cc2cccc(c2)-c2nnn[nH]2)(C(O)=O)C(O)=O)[C@@H](O)[C@@H]1F
Show InChI InChI=1/C21H19ClFN9O7/c22-20-26-14(24)12-16(27-20)32(7-25-12)17-11(23)13(33)10(39-17)6-38-21(18(34)35,19(36)37)5-8-2-1-3-9(4-8)15-28-30-31-29-15/h1-4,7,10-11,13,17,33H,5-6H2,(H,34,35)(H,36,37)(H2,24,26,27)(H,28,29,30,31)/t10-,11+,13-,17-/s2
PDB

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n/an/a 448n/an/an/an/an/an/a



Calithera Biosciences, Inc.

US Patent


Assay Description
For measurements of soluble CD73 enzyme activity, recombinant CD73 was obtained from R&D Systems, Cat. No. 5795-EN-010. Serial dilutions of test comp...


US Patent US10472364 (2019)

More data for this
Ligand-Target Pair
5'-nucleotidase


(Homo sapiens (Human))
BDBM420026
PNG
(US10472364, Compound 98)
Show SMILES CNC(=O)c1ccc(CC(OC[C@H]2O[C@H]([C@@H](F)[C@@H]2O)n2cnc3c(N)nc(Cl)nc23)(C(O)=O)C(O)=O)cc1
Show InChI InChI=1S/C22H22ClFN6O8/c1-26-17(32)10-4-2-9(3-5-10)6-22(19(33)34,20(35)36)37-7-11-14(31)12(24)18(38-11)30-8-27-13-15(25)28-21(23)29-16(13)30/h2-5,8,11-12,14,18,31H,6-7H2,1H3,(H,26,32)(H,33,34)(H,35,36)(H2,25,28,29)/t11-,12+,14-,18-/m1/s1
PDB

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n/an/a 512n/an/an/an/an/an/a



Calithera Biosciences, Inc.

US Patent


Assay Description
For measurements of soluble CD73 enzyme activity, recombinant CD73 was obtained from R&D Systems, Cat. No. 5795-EN-010. Serial dilutions of test comp...


US Patent US10472364 (2019)

More data for this
Ligand-Target Pair
5'-nucleotidase


(Homo sapiens (Human))
BDBM419936
PNG
(US10472364, Compound 22)
Show SMILES CN(C)C(=O)c1cccc(CC(OC[C@H]2O[C@H]([C@@H](F)[C@@H]2O)n2cnc3c(N)nc(Cl)nc23)(C(O)=O)C(O)=O)c1
Show InChI InChI=1S/C23H24ClFN6O8/c1-30(2)18(33)11-5-3-4-10(6-11)7-23(20(34)35,21(36)37)38-8-12-15(32)13(25)19(39-12)31-9-27-14-16(26)28-22(24)29-17(14)31/h3-6,9,12-13,15,19,32H,7-8H2,1-2H3,(H,34,35)(H,36,37)(H2,26,28,29)/t12-,13+,15-,19-/m1/s1
PDB

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n/an/a 521n/an/an/an/an/an/a



Calithera Biosciences, Inc.

US Patent


Assay Description
For measurements of soluble CD73 enzyme activity, recombinant CD73 was obtained from R&D Systems, Cat. No. 5795-EN-010. Serial dilutions of test comp...


US Patent US10472364 (2019)

More data for this
Ligand-Target Pair
5'-nucleotidase


(Homo sapiens (Human))
BDBM419949
PNG
(US10472364, Compound 35)
Show SMILES Nc1nc(Cl)nc2n(cnc12)[C@@H]1O[C@H](COC(Cc2cccc(c2)C#N)(C(O)=O)C(O)=O)[C@@H](O)[C@@H]1F
Show InChI InChI=1S/C21H18ClFN6O7/c22-20-27-15(25)13-16(28-20)29(8-26-13)17-12(23)14(30)11(36-17)7-35-21(18(31)32,19(33)34)5-9-2-1-3-10(4-9)6-24/h1-4,8,11-12,14,17,30H,5,7H2,(H,31,32)(H,33,34)(H2,25,27,28)/t11-,12+,14-,17-/m1/s1
PDB

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n/an/a 531n/an/an/an/an/an/a



Calithera Biosciences, Inc.

US Patent


Assay Description
For measurements of soluble CD73 enzyme activity, recombinant CD73 was obtained from R&D Systems, Cat. No. 5795-EN-010. Serial dilutions of test comp...


US Patent US10472364 (2019)

More data for this
Ligand-Target Pair
5'-nucleotidase


(Homo sapiens (Human))
BDBM419998
PNG
(US10472364, Compound 67)
Show SMILES Nc1nc(Cl)nc2n(cnc12)[C@@H]1O[C@H](COC(Cc2cnc(s2)C(O)=O)(C(O)=O)C(O)=O)[C@@H](O)[C@@H]1F
Show InChI InChI=1S/C18H16ClFN6O9S/c19-17-24-10(21)8-11(25-17)26(4-23-8)13-7(20)9(27)6(35-13)3-34-18(15(30)31,16(32)33)1-5-2-22-12(36-5)14(28)29/h2,4,6-7,9,13,27H,1,3H2,(H,28,29)(H,30,31)(H,32,33)(H2,21,24,25)/t6-,7+,9-,13-/m1/s1
PDB

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n/an/a 602n/an/an/an/an/an/a



Calithera Biosciences, Inc.

US Patent


Assay Description
For measurements of soluble CD73 enzyme activity, recombinant CD73 was obtained from R&D Systems, Cat. No. 5795-EN-010. Serial dilutions of test comp...


US Patent US10472364 (2019)

More data for this
Ligand-Target Pair
5'-nucleotidase


(Homo sapiens (Human))
BDBM419951
PNG
(US10472364, Compound 37 | US10472364, Compound 38)
Show SMILES CCOC(=O)C(Cc1ccc(OC(F)(F)F)cc1)(OC[C@H]1O[C@H]([C@@H](F)[C@@H]1O)n1cnc2c(N)nc(Cl)nc12)C(O)=O
Show InChI InChI=1S/C23H22ClF4N5O8/c1-2-38-20(37)22(19(35)36,7-10-3-5-11(6-4-10)41-23(26,27)28)39-8-12-15(34)13(25)18(40-12)33-9-30-14-16(29)31-21(24)32-17(14)33/h3-6,9,12-13,15,18,34H,2,7-8H2,1H3,(H,35,36)(H2,29,31,32)/t12-,13+,15-,18-,22?/m1/s1
PDB

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n/an/a 686n/an/an/an/an/an/a



Calithera Biosciences, Inc.

US Patent


Assay Description
For measurements of soluble CD73 enzyme activity, recombinant CD73 was obtained from R&D Systems, Cat. No. 5795-EN-010. Serial dilutions of test comp...


US Patent US10472364 (2019)

More data for this
Ligand-Target Pair
5'-nucleotidase


(Homo sapiens (Human))
BDBM419930
PNG
(US10472364, Compound 17)
Show SMILES Nc1nc(Cl)nc2n(cnc12)[C@@H]1O[C@H](COC(Cc2ccc3ccccc3c2)(C(O)=O)C(O)=O)[C@@H](O)[C@@H]1F
Show InChI InChI=1S/C24H21ClFN5O7/c25-23-29-18(27)16-19(30-23)31(10-28-16)20-15(26)17(32)14(38-20)9-37-24(21(33)34,22(35)36)8-11-5-6-12-3-1-2-4-13(12)7-11/h1-7,10,14-15,17,20,32H,8-9H2,(H,33,34)(H,35,36)(H2,27,29,30)/t14-,15+,17-,20-/m1/s1
PDB

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n/an/a 699n/an/an/an/an/an/a



Calithera Biosciences, Inc.

US Patent


Assay Description
For measurements of soluble CD73 enzyme activity, recombinant CD73 was obtained from R&D Systems, Cat. No. 5795-EN-010. Serial dilutions of test comp...


US Patent US10472364 (2019)

More data for this
Ligand-Target Pair
5'-nucleotidase


(Homo sapiens (Human))
BDBM419951
PNG
(US10472364, Compound 37 | US10472364, Compound 38)
Show SMILES CCOC(=O)C(Cc1ccc(OC(F)(F)F)cc1)(OC[C@H]1O[C@H]([C@@H](F)[C@@H]1O)n1cnc2c(N)nc(Cl)nc12)C(O)=O
Show InChI InChI=1S/C23H22ClF4N5O8/c1-2-38-20(37)22(19(35)36,7-10-3-5-11(6-4-10)41-23(26,27)28)39-8-12-15(34)13(25)18(40-12)33-9-30-14-16(29)31-21(24)32-17(14)33/h3-6,9,12-13,15,18,34H,2,7-8H2,1H3,(H,35,36)(H2,29,31,32)/t12-,13+,15-,18-,22?/m1/s1
PDB

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n/an/a 718n/an/an/an/an/an/a



Calithera Biosciences, Inc.

US Patent


Assay Description
For measurements of soluble CD73 enzyme activity, recombinant CD73 was obtained from R&D Systems, Cat. No. 5795-EN-010. Serial dilutions of test comp...


US Patent US10472364 (2019)

More data for this
Ligand-Target Pair
5'-nucleotidase


(Homo sapiens (Human))
BDBM420024
PNG
(US10472364, Compound 96)
Show SMILES Nc1nc(Cl)nc2n(cnc12)[C@@H]1O[C@H](COC(Cc2csc3ccc(Cl)cc23)(C(O)=O)C(O)=O)[C@@H](O)[C@@H]1F
Show InChI InChI=1S/C22H18Cl2FN5O7S/c23-9-1-2-12-10(3-9)8(6-38-12)4-22(19(32)33,20(34)35)36-5-11-15(31)13(25)18(37-11)30-7-27-14-16(26)28-21(24)29-17(14)30/h1-3,6-7,11,13,15,18,31H,4-5H2,(H,32,33)(H,34,35)(H2,26,28,29)/t11-,13+,15-,18-/m1/s1
PDB

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n/an/a 788n/an/an/an/an/an/a



Calithera Biosciences, Inc.

US Patent


Assay Description
For measurements of soluble CD73 enzyme activity, recombinant CD73 was obtained from R&D Systems, Cat. No. 5795-EN-010. Serial dilutions of test comp...


US Patent US10472364 (2019)

More data for this
Ligand-Target Pair
5'-nucleotidase


(Homo sapiens (Human))
BDBM419964
PNG
(US10472364, Compound 49)
Show SMILES COc1cccc(CC(OC[C@H]2O[C@H]([C@@H](F)[C@@H]2O)n2cnc3c(N)nc(Cl)nc23)(C(O)=O)C(O)=O)c1
Show InChI InChI=1S/C21H21ClFN5O8/c1-34-10-4-2-3-9(5-10)6-21(18(30)31,19(32)33)35-7-11-14(29)12(23)17(36-11)28-8-25-13-15(24)26-20(22)27-16(13)28/h2-5,8,11-12,14,17,29H,6-7H2,1H3,(H,30,31)(H,32,33)(H2,24,26,27)/t11-,12+,14-,17-/m1/s1
PDB

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n/an/a 839n/an/an/an/an/an/a



Calithera Biosciences, Inc.

US Patent


Assay Description
For measurements of soluble CD73 enzyme activity, recombinant CD73 was obtained from R&D Systems, Cat. No. 5795-EN-010. Serial dilutions of test comp...


US Patent US10472364 (2019)

More data for this
Ligand-Target Pair
5'-nucleotidase


(Homo sapiens (Human))
BDBM419991
PNG
(US10472364, Compound 64)
Show SMILES Nc1nc(Cl)nc2n(cnc12)[C@@H]1O[C@H](COC(Cc2cn[nH]c2)(C(O)=O)C(O)=O)[C@@H](O)[C@@H]1F
Show InChI InChI=1/C17H17ClFN7O7/c18-16-24-11(20)9-12(25-16)26(5-21-9)13-8(19)10(27)7(33-13)4-32-17(14(28)29,15(30)31)1-6-2-22-23-3-6/h2-3,5,7-8,10,13,27H,1,4H2,(H,22,23)(H,28,29)(H,30,31)(H2,20,24,25)/t7-,8+,10-,13-/s2
PDB

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n/an/a 860n/an/an/an/an/an/a



Calithera Biosciences, Inc.

US Patent


Assay Description
For measurements of soluble CD73 enzyme activity, recombinant CD73 was obtained from R&D Systems, Cat. No. 5795-EN-010. Serial dilutions of test comp...


US Patent US10472364 (2019)

More data for this
Ligand-Target Pair
5'-nucleotidase


(Homo sapiens (Human))
BDBM420002
PNG
(US10472364, Compound 75)
Show SMILES Nc1nc(Cl)nc2n(cnc12)[C@@H]1O[C@H](COC(Cc2ccc(C#N)c(F)c2)(C(O)=O)C(O)=O)[C@@H](O)[C@@H]1F
Show InChI InChI=1S/C21H17ClF2N6O7/c22-20-28-15(26)13-16(29-20)30(7-27-13)17-12(24)14(31)11(37-17)6-36-21(18(32)33,19(34)35)4-8-1-2-9(5-25)10(23)3-8/h1-3,7,11-12,14,17,31H,4,6H2,(H,32,33)(H,34,35)(H2,26,28,29)/t11-,12+,14-,17-/m1/s1
PDB

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n/an/a 887n/an/an/an/an/an/a



Calithera Biosciences, Inc.

US Patent


Assay Description
For measurements of soluble CD73 enzyme activity, recombinant CD73 was obtained from R&D Systems, Cat. No. 5795-EN-010. Serial dilutions of test comp...


US Patent US10472364 (2019)

More data for this
Ligand-Target Pair
5'-nucleotidase


(Homo sapiens (Human))
BDBM420022
PNG
(US10472364, Compound 94)
Show SMILES Cc1nnc(o1)-c1ccc(CC(OC[C@H]2O[C@H]([C@@H](F)[C@@H]2O)n2cnc3c(N)nc(Cl)nc23)(C(O)=O)C(O)=O)cc1
Show InChI InChI=1S/C23H21ClFN7O8/c1-9-30-31-18(39-9)11-4-2-10(3-5-11)6-23(20(34)35,21(36)37)38-7-12-15(33)13(25)19(40-12)32-8-27-14-16(26)28-22(24)29-17(14)32/h2-5,8,12-13,15,19,33H,6-7H2,1H3,(H,34,35)(H,36,37)(H2,26,28,29)/t12-,13+,15-,19-/m1/s1
PDB

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n/an/a 906n/an/an/an/an/an/a



Calithera Biosciences, Inc.

US Patent


Assay Description
For measurements of soluble CD73 enzyme activity, recombinant CD73 was obtained from R&D Systems, Cat. No. 5795-EN-010. Serial dilutions of test comp...


US Patent US10472364 (2019)

More data for this
Ligand-Target Pair
5'-nucleotidase


(Homo sapiens (Human))
BDBM419961
PNG
(US10472364, Compound 43)
Show SMILES Nc1nc(N=[N+]=[N-])nc2n(cnc12)[C@@H]1O[C@H](COC(Cc2cccc(c2)-c2nnn[nH]2)(C(O)=O)C(O)=O)[C@@H](O)[C@@H]1F
Show InChI InChI=1/C21H19FN12O7/c22-11-13(35)10(41-17(11)34-7-25-12-14(23)26-20(30-31-24)27-16(12)34)6-40-21(18(36)37,19(38)39)5-8-2-1-3-9(4-8)15-28-32-33-29-15/h1-4,7,10-11,13,17,35H,5-6H2,(H,36,37)(H,38,39)(H2,23,26,27)(H,28,29,32,33)/t10-,11+,13-,17-/s2
PDB

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n/an/a 1.04E+3n/an/an/an/an/an/a



Calithera Biosciences, Inc.

US Patent


Assay Description
For measurements of soluble CD73 enzyme activity, recombinant CD73 was obtained from R&D Systems, Cat. No. 5795-EN-010. Serial dilutions of test comp...


US Patent US10472364 (2019)

More data for this
Ligand-Target Pair
5'-nucleotidase


(Homo sapiens (Human))
BDBM419987
PNG
(US10472364, Compound 63)
Show SMILES Nc1nc(Cl)nc2n(cnc12)[C@@H]1O[C@H](COC(Cc2cnn(Cc3ccccc3)c2)(C(O)=O)C(O)=O)[C@@H](O)[C@@H]1F
Show InChI InChI=1S/C24H23ClFN7O7/c25-23-30-18(27)16-19(31-23)33(11-28-16)20-15(26)17(34)14(40-20)10-39-24(21(35)36,22(37)38)6-13-7-29-32(9-13)8-12-4-2-1-3-5-12/h1-5,7,9,11,14-15,17,20,34H,6,8,10H2,(H,35,36)(H,37,38)(H2,27,30,31)/t14-,15+,17-,20-/m1/s1
PDB

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n/an/a 1.22E+3n/an/an/an/an/an/a



Calithera Biosciences, Inc.

US Patent


Assay Description
For measurements of soluble CD73 enzyme activity, recombinant CD73 was obtained from R&D Systems, Cat. No. 5795-EN-010. Serial dilutions of test comp...


US Patent US10472364 (2019)

More data for this
Ligand-Target Pair
5'-nucleotidase


(Homo sapiens (Human))
BDBM419954
PNG
(US10472364, Compound 40)
Show SMILES Nc1nc(N=[N+]=[N-])nc2n(cnc12)[C@@H]1O[C@H](COC(Cc2cccc(c2)C#N)(C(O)=O)C(O)=O)[C@@H](O)[C@@H]1F
Show InChI InChI=1S/C21H18FN9O7/c22-12-14(32)11(38-17(12)31-8-26-13-15(24)27-20(29-30-25)28-16(13)31)7-37-21(18(33)34,19(35)36)5-9-2-1-3-10(4-9)6-23/h1-4,8,11-12,14,17,32H,5,7H2,(H,33,34)(H,35,36)(H2,24,27,28)/t11-,12+,14-,17-/m1/s1
PDB

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n/an/a 1.28E+3n/an/an/an/an/an/a



Calithera Biosciences, Inc.

US Patent


Assay Description
For measurements of soluble CD73 enzyme activity, recombinant CD73 was obtained from R&D Systems, Cat. No. 5795-EN-010. Serial dilutions of test comp...


US Patent US10472364 (2019)

More data for this
Ligand-Target Pair
5'-nucleotidase


(Homo sapiens (Human))
BDBM419947
PNG
(US10472364, Compound 33)
Show SMILES Nc1nc(Cl)nc2n(cnc12)[C@@H]1O[C@H](COC(CC#N)(C(O)=O)C(O)=O)[C@@H](O)[C@@H]1F
Show InChI InChI=1S/C15H14ClFN6O7/c16-14-21-9(19)7-10(22-14)23(4-20-7)11-6(17)8(24)5(30-11)3-29-15(1-2-18,12(25)26)13(27)28/h4-6,8,11,24H,1,3H2,(H,25,26)(H,27,28)(H2,19,21,22)/t5-,6+,8-,11-/m1/s1
PDB

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n/an/a 1.51E+3n/an/an/an/an/an/a



Calithera Biosciences, Inc.

US Patent


Assay Description
For measurements of soluble CD73 enzyme activity, recombinant CD73 was obtained from R&D Systems, Cat. No. 5795-EN-010. Serial dilutions of test comp...


US Patent US10472364 (2019)

More data for this
Ligand-Target Pair
5'-nucleotidase


(Homo sapiens (Human))
BDBM420001
PNG
(US10472364, Compound 74)
Show SMILES O[C@@H]1[C@@H](COC(Cc2ccccc2)(C(O)=O)C(O)=O)O[C@H]([C@H]1F)n1cnc2c(O)nc(Cl)nc12
Show InChI InChI=1S/C20H18ClFN4O8/c21-19-24-14-12(15(28)25-19)23-8-26(14)16-11(22)13(27)10(34-16)7-33-20(17(29)30,18(31)32)6-9-4-2-1-3-5-9/h1-5,8,10-11,13,16,27H,6-7H2,(H,29,30)(H,31,32)(H,24,25,28)/t10-,11+,13-,16-/m1/s1
PDB

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n/an/a 1.66E+3n/an/an/an/an/an/a



Calithera Biosciences, Inc.

US Patent


Assay Description
For measurements of soluble CD73 enzyme activity, recombinant CD73 was obtained from R&D Systems, Cat. No. 5795-EN-010. Serial dilutions of test comp...


US Patent US10472364 (2019)

More data for this
Ligand-Target Pair
5'-nucleotidase


(Homo sapiens (Human))
BDBM419955
PNG
(US10472364, Compound 41)
Show SMILES CC(C)(C)OC(=O)Nc1nc(N=[N+]=[N-])nc2n(cnc12)[C@@H]1O[C@H](COC(Cc2cccc(c2)C#N)(C(O)=O)C(O)=O)[C@@H](O)[C@@H]1F
Show InChI InChI=1S/C26H26FN9O9/c1-25(2,3)45-24(42)32-18-16-19(33-23(31-18)34-35-29)36(11-30-16)20-15(27)17(37)14(44-20)10-43-26(21(38)39,22(40)41)8-12-5-4-6-13(7-12)9-28/h4-7,11,14-15,17,20,37H,8,10H2,1-3H3,(H,38,39)(H,40,41)(H,31,32,33,42)/t14-,15+,17-,20-/m1/s1
PDB

UniProtKB/SwissProt

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US Patent
n/an/a 1.79E+3n/an/an/an/an/an/a



Calithera Biosciences, Inc.

US Patent


Assay Description
For measurements of soluble CD73 enzyme activity, recombinant CD73 was obtained from R&D Systems, Cat. No. 5795-EN-010. Serial dilutions of test comp...


US Patent US10472364 (2019)

More data for this
Ligand-Target Pair
5'-nucleotidase


(Homo sapiens (Human))
BDBM419966
PNG
(US10472364, Compound 51)
Show SMILES N[C@@H]1[C@@H](COC(Cc2ccccc2)(C(O)=O)C(O)=O)O[C@H]([C@@H]1O)n1cnc2c(N)nc(Cl)nc12
Show InChI InChI=1S/C20H21ClN6O7/c21-19-25-14(23)12-15(26-19)27(8-24-12)16-13(28)11(22)10(34-16)7-33-20(17(29)30,18(31)32)6-9-4-2-1-3-5-9/h1-5,8,10-11,13,16,28H,6-7,22H2,(H,29,30)(H,31,32)(H2,23,25,26)/t10-,11-,13-,16-/m1/s1
PDB

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n/an/a 1.87E+3n/an/an/an/an/an/a



Calithera Biosciences, Inc.

US Patent


Assay Description
For measurements of soluble CD73 enzyme activity, recombinant CD73 was obtained from R&D Systems, Cat. No. 5795-EN-010. Serial dilutions of test comp...


US Patent US10472364 (2019)

More data for this
Ligand-Target Pair
5'-nucleotidase


(Homo sapiens (Human))
BDBM419931
PNG
(US10472364, Compound 18)
Show SMILES Nc1nc(Cl)nc2n(cnc12)[C@@H]1O[C@H](COC(CCCCO)(C(O)=O)C(O)=O)[C@@H](O)[C@@H]1F
Show InChI InChI=1S/C17H21ClFN5O8/c18-16-22-11(20)9-12(23-16)24(6-21-9)13-8(19)10(26)7(32-13)5-31-17(14(27)28,15(29)30)3-1-2-4-25/h6-8,10,13,25-26H,1-5H2,(H,27,28)(H,29,30)(H2,20,22,23)/t7-,8+,10-,13-/m1/s1
PDB

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n/an/a 1.89E+3n/an/an/an/an/an/a



Calithera Biosciences, Inc.

US Patent


Assay Description
For measurements of soluble CD73 enzyme activity, recombinant CD73 was obtained from R&D Systems, Cat. No. 5795-EN-010. Serial dilutions of test comp...


US Patent US10472364 (2019)

More data for this
Ligand-Target Pair
5'-nucleotidase


(Homo sapiens (Human))
BDBM419946
PNG
(US10472364, Compound 50)
Show SMILES Nc1nc(Cl)nc2n(cnc12)[C@@H]1O[C@H](COC(Cc2nnn[nH]2)(C(O)=O)C(O)=O)[C@@H](O)[C@@H]1F
Show InChI InChI=1/C15H15ClFN9O7/c16-14-20-9(18)7-10(21-14)26(3-19-7)11-6(17)8(27)4(33-11)2-32-15(12(28)29,13(30)31)1-5-22-24-25-23-5/h3-4,6,8,11,27H,1-2H2,(H,28,29)(H,30,31)(H2,18,20,21)(H,22,23,24,25)/t4-,6+,8-,11-/s2
PDB

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n/an/a 1.91E+3n/an/an/an/an/an/a



Calithera Biosciences, Inc.

US Patent


Assay Description
For measurements of soluble CD73 enzyme activity, recombinant CD73 was obtained from R&D Systems, Cat. No. 5795-EN-010. Serial dilutions of test comp...


US Patent US10472364 (2019)

More data for this
Ligand-Target Pair
5'-nucleotidase


(Homo sapiens (Human))
BDBM419986
PNG
(US10472364, Compound 61)
Show SMILES Nc1nc(Cl)nc2n(cnc12)[C@@H]1O[C@H](COC(Cc2cc(no2)-c2ccccc2)(C(O)=O)C(O)=O)[C@@H](O)[C@@H]1F
Show InChI InChI=1S/C23H20ClFN6O8/c24-22-28-17(26)15-18(29-22)31(9-27-15)19-14(25)16(32)13(38-19)8-37-23(20(33)34,21(35)36)7-11-6-12(30-39-11)10-4-2-1-3-5-10/h1-6,9,13-14,16,19,32H,7-8H2,(H,33,34)(H,35,36)(H2,26,28,29)/t13-,14+,16-,19-/m1/s1
PDB

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n/an/a 2.25E+3n/an/an/an/an/an/a



Calithera Biosciences, Inc.

US Patent


Assay Description
For measurements of soluble CD73 enzyme activity, recombinant CD73 was obtained from R&D Systems, Cat. No. 5795-EN-010. Serial dilutions of test comp...


US Patent US10472364 (2019)

More data for this
Ligand-Target Pair
5'-nucleotidase


(Homo sapiens (Human))
BDBM419917
PNG
(US10472364, Compound 3 | US10472364, Compound 4)
Show SMILES CCOC(=O)C(OC[C@H]1O[C@H]([C@@H](F)[C@@H]1O)n1cnc2c(NC(=O)OC(C)(C)C)nc(Cl)nc12)P(O)(O)=O
Show InChI InChI=1S/C19H26ClFN5O10P/c1-5-33-15(28)16(37(30,31)32)34-6-8-11(27)9(21)14(35-8)26-7-22-10-12(23-17(20)25-13(10)26)24-18(29)36-19(2,3)4/h7-9,11,14,16,27H,5-6H2,1-4H3,(H2,30,31,32)(H,23,24,25,29)/t8-,9+,11-,14-,16?/m1/s1
PDB

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n/an/a 2.47E+3n/an/an/an/an/an/a



Calithera Biosciences, Inc.

US Patent


Assay Description
For measurements of soluble CD73 enzyme activity, recombinant CD73 was obtained from R&D Systems, Cat. No. 5795-EN-010. Serial dilutions of test comp...


US Patent US10472364 (2019)

More data for this
Ligand-Target Pair
5'-nucleotidase


(Homo sapiens (Human))
BDBM419933
PNG
(US10472364, Compound 19)
Show SMILES Nc1nc(Cl)nc2n(cnc12)[C@@H]1O[C@H](COC(CC(O)=O)(C(O)=O)C(O)=O)[C@@H](O)[C@@H]1F
Show InChI InChI=1S/C15H15ClFN5O9/c16-14-20-9(18)7-10(21-14)22(3-19-7)11-6(17)8(25)4(31-11)2-30-15(12(26)27,13(28)29)1-5(23)24/h3-4,6,8,11,25H,1-2H2,(H,23,24)(H,26,27)(H,28,29)(H2,18,20,21)/t4-,6+,8-,11-/m1/s1
PDB

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n/an/a 2.56E+3n/an/an/an/an/an/a



Calithera Biosciences, Inc.

US Patent


Assay Description
For measurements of soluble CD73 enzyme activity, recombinant CD73 was obtained from R&D Systems, Cat. No. 5795-EN-010. Serial dilutions of test comp...


US Patent US10472364 (2019)

More data for this
Ligand-Target Pair
5'-nucleotidase


(Homo sapiens (Human))
BDBM419942
PNG
(US10472364, Compound 28)
Show SMILES O[C@@H]1[C@@H](COC(Cc2ccccc2)(C(O)=O)C(O)=O)O[C@H]([C@H]1F)n1cnc2c(NCc3ccccc3)nc(Cl)nc12
Show InChI InChI=1S/C27H25ClFN5O7/c28-26-32-21(30-12-16-9-5-2-6-10-16)19-22(33-26)34(14-31-19)23-18(29)20(35)17(41-23)13-40-27(24(36)37,25(38)39)11-15-7-3-1-4-8-15/h1-10,14,17-18,20,23,35H,11-13H2,(H,36,37)(H,38,39)(H,30,32,33)/t17-,18+,20-,23-/m1/s1
PDB

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n/an/a 2.65E+3n/an/an/an/an/an/a



Calithera Biosciences, Inc.

US Patent


Assay Description
For measurements of soluble CD73 enzyme activity, recombinant CD73 was obtained from R&D Systems, Cat. No. 5795-EN-010. Serial dilutions of test comp...


US Patent US10472364 (2019)

More data for this
Ligand-Target Pair
5'-nucleotidase


(Homo sapiens (Human))
BDBM419914
PNG
(US10472364, Compound 1 | US10472364, Compound 2)
Show SMILES CCOC(=O)C(OC[C@H]1O[C@H]([C@@H](F)[C@@H]1O)n1cnc2c(N)nc(Cl)nc12)P(O)(O)=O
Show InChI InChI=1S/C14H18ClFN5O8P/c1-2-27-12(23)13(30(24,25)26)28-3-5-8(22)6(16)11(29-5)21-4-18-7-9(17)19-14(15)20-10(7)21/h4-6,8,11,13,22H,2-3H2,1H3,(H2,17,19,20)(H2,24,25,26)/t5-,6+,8-,11-,13?/m1/s1
PDB

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n/an/a 2.79E+3n/an/an/an/an/an/a



Calithera Biosciences, Inc.

US Patent


Assay Description
For measurements of soluble CD73 enzyme activity, recombinant CD73 was obtained from R&D Systems, Cat. No. 5795-EN-010. Serial dilutions of test comp...


US Patent US10472364 (2019)

More data for this
Ligand-Target Pair
5'-nucleotidase


(Homo sapiens (Human))
BDBM420011
PNG
(US10472364, Compound 81 | US10472364, Compound 82)
Show SMILES COC(=O)C(Cc1ccc(cc1)-c1ccccc1)(OC[C@H]1O[C@H]([C@@H](F)[C@@H]1O)n1cnc2c(N)nc(Cl)nc12)C(O)=O
Show InChI InChI=1S/C27H25ClFN5O7/c1-39-25(38)27(24(36)37,11-14-7-9-16(10-8-14)15-5-3-2-4-6-15)40-12-17-20(35)18(29)23(41-17)34-13-31-19-21(30)32-26(28)33-22(19)34/h2-10,13,17-18,20,23,35H,11-12H2,1H3,(H,36,37)(H2,30,32,33)/t17-,18+,20-,23-,27?/m1/s1
PDB

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n/an/a 2.86E+3n/an/an/an/an/an/a



Calithera Biosciences, Inc.

US Patent


Assay Description
For measurements of soluble CD73 enzyme activity, recombinant CD73 was obtained from R&D Systems, Cat. No. 5795-EN-010. Serial dilutions of test comp...


US Patent US10472364 (2019)

More data for this
Ligand-Target Pair
5'-nucleotidase


(Homo sapiens (Human))
BDBM419917
PNG
(US10472364, Compound 3 | US10472364, Compound 4)
Show SMILES CCOC(=O)C(OC[C@H]1O[C@H]([C@@H](F)[C@@H]1O)n1cnc2c(NC(=O)OC(C)(C)C)nc(Cl)nc12)P(O)(O)=O
Show InChI InChI=1S/C19H26ClFN5O10P/c1-5-33-15(28)16(37(30,31)32)34-6-8-11(27)9(21)14(35-8)26-7-22-10-12(23-17(20)25-13(10)26)24-18(29)36-19(2,3)4/h7-9,11,14,16,27H,5-6H2,1-4H3,(H2,30,31,32)(H,23,24,25,29)/t8-,9+,11-,14-,16?/m1/s1
PDB

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n/an/a 2.95E+3n/an/an/an/an/an/a



Calithera Biosciences, Inc.

US Patent


Assay Description
For measurements of soluble CD73 enzyme activity, recombinant CD73 was obtained from R&D Systems, Cat. No. 5795-EN-010. Serial dilutions of test comp...


US Patent US10472364 (2019)

More data for this
Ligand-Target Pair
5'-nucleotidase


(Homo sapiens (Human))
BDBM420025
PNG
(US10472364, Compound 97)
Show SMILES Nc1nc(Cl)nc2n(cnc12)[C@@H]1O[C@H](COC(Cc2nc3ccccc3s2)(C(O)=O)C(O)=O)[C@@H](O)[C@@H]1F
Show InChI InChI=1S/C21H18ClFN6O7S/c22-20-27-15(24)13-16(28-20)29(7-25-13)17-12(23)14(30)9(36-17)6-35-21(18(31)32,19(33)34)5-11-26-8-3-1-2-4-10(8)37-11/h1-4,7,9,12,14,17,30H,5-6H2,(H,31,32)(H,33,34)(H2,24,27,28)/t9-,12+,14-,17-/m1/s1
PDB

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n/an/a 3.43E+3n/an/an/an/an/an/a



Calithera Biosciences, Inc.

US Patent


Assay Description
For measurements of soluble CD73 enzyme activity, recombinant CD73 was obtained from R&D Systems, Cat. No. 5795-EN-010. Serial dilutions of test comp...


US Patent US10472364 (2019)

More data for this
Ligand-Target Pair
5'-nucleotidase


(Homo sapiens (Human))
BDBM420011
PNG
(US10472364, Compound 81 | US10472364, Compound 82)
Show SMILES COC(=O)C(Cc1ccc(cc1)-c1ccccc1)(OC[C@H]1O[C@H]([C@@H](F)[C@@H]1O)n1cnc2c(N)nc(Cl)nc12)C(O)=O
Show InChI InChI=1S/C27H25ClFN5O7/c1-39-25(38)27(24(36)37,11-14-7-9-16(10-8-14)15-5-3-2-4-6-15)40-12-17-20(35)18(29)23(41-17)34-13-31-19-21(30)32-26(28)33-22(19)34/h2-10,13,17-18,20,23,35H,11-12H2,1H3,(H,36,37)(H2,30,32,33)/t17-,18+,20-,23-,27?/m1/s1
PDB

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n/an/a 3.43E+3n/an/an/an/an/an/a



Calithera Biosciences, Inc.

US Patent


Assay Description
For measurements of soluble CD73 enzyme activity, recombinant CD73 was obtained from R&D Systems, Cat. No. 5795-EN-010. Serial dilutions of test comp...


US Patent US10472364 (2019)

More data for this
Ligand-Target Pair
5'-nucleotidase


(Homo sapiens (Human))
BDBM419939
PNG
(US10472364, Compound 24)
Show SMILES COC(=O)C(OC[C@H]1O[C@H]([C@@H](F)[C@@H]1O)n1cnc2c(N)nc(Cl)nc12)P(O)(O)=O
Show InChI InChI=1S/C13H16ClFN5O8P/c1-26-11(22)12(29(23,24)25)27-2-4-7(21)5(15)10(28-4)20-3-17-6-8(16)18-13(14)19-9(6)20/h3-5,7,10,12,21H,2H2,1H3,(H2,16,18,19)(H2,23,24,25)/t4-,5+,7-,10-,12?/m1/s1
PDB

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n/an/a 5.90E+3n/an/an/an/an/an/a



Calithera Biosciences, Inc.

US Patent


Assay Description
For measurements of soluble CD73 enzyme activity, recombinant CD73 was obtained from R&D Systems, Cat. No. 5795-EN-010. Serial dilutions of test comp...


US Patent US10472364 (2019)

More data for this
Ligand-Target Pair
5'-nucleotidase


(Homo sapiens (Human))
BDBM420013
PNG
(US10472364, Compound 83)
Show SMILES Nc1nc(Cl)nc2n(cnc12)[C@@H]1O[C@H](COC(Cc2cc(no2)C(O)=O)(C(O)=O)C(O)=O)[C@@H](O)[C@@H]1F
Show InChI InChI=1S/C18H16ClFN6O10/c19-17-23-11(21)9-12(24-17)26(4-22-9)13-8(20)10(27)7(35-13)3-34-18(15(30)31,16(32)33)2-5-1-6(14(28)29)25-36-5/h1,4,7-8,10,13,27H,2-3H2,(H,28,29)(H,30,31)(H,32,33)(H2,21,23,24)/t7-,8+,10-,13-/m1/s1
PDB

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n/an/a 6.44E+3n/an/an/an/an/an/a



Calithera Biosciences, Inc.

US Patent


Assay Description
For measurements of soluble CD73 enzyme activity, recombinant CD73 was obtained from R&D Systems, Cat. No. 5795-EN-010. Serial dilutions of test comp...


US Patent US10472364 (2019)

More data for this
Ligand-Target Pair
5'-nucleotidase


(Homo sapiens (Human))
BDBM420014
PNG
(US10472364, Compound 84)
Show SMILES CCOC(=O)C(Cc1ccc(cc1)-c1ccccc1)(OC[C@H]1O[C@H]([C@@H](F)[C@@H]1O)n1cnc2c(N)nc(Cl)nc12)C(O)=O
Show InChI InChI=1S/C28H27ClFN5O7/c1-2-40-26(39)28(25(37)38,12-15-8-10-17(11-9-15)16-6-4-3-5-7-16)41-13-18-21(36)19(30)24(42-18)35-14-32-20-22(31)33-27(29)34-23(20)35/h3-11,14,18-19,21,24,36H,2,12-13H2,1H3,(H,37,38)(H2,31,33,34)/t18-,19+,21-,24-,28?/m1/s1
PDB

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n/an/a 7.26E+3n/an/an/an/an/an/a



Calithera Biosciences, Inc.

US Patent


Assay Description
For measurements of soluble CD73 enzyme activity, recombinant CD73 was obtained from R&D Systems, Cat. No. 5795-EN-010. Serial dilutions of test comp...


US Patent US10472364 (2019)

More data for this
Ligand-Target Pair
5'-nucleotidase


(Homo sapiens (Human))
BDBM420014
PNG
(US10472364, Compound 84)
Show SMILES CCOC(=O)C(Cc1ccc(cc1)-c1ccccc1)(OC[C@H]1O[C@H]([C@@H](F)[C@@H]1O)n1cnc2c(N)nc(Cl)nc12)C(O)=O
Show InChI InChI=1S/C28H27ClFN5O7/c1-2-40-26(39)28(25(37)38,12-15-8-10-17(11-9-15)16-6-4-3-5-7-16)41-13-18-21(36)19(30)24(42-18)35-14-32-20-22(31)33-27(29)34-23(20)35/h3-11,14,18-19,21,24,36H,2,12-13H2,1H3,(H,37,38)(H2,31,33,34)/t18-,19+,21-,24-,28?/m1/s1
PDB

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n/an/a 8.26E+3n/an/an/an/an/an/a



Calithera Biosciences, Inc.

US Patent


Assay Description
For measurements of soluble CD73 enzyme activity, recombinant CD73 was obtained from R&D Systems, Cat. No. 5795-EN-010. Serial dilutions of test comp...


US Patent US10472364 (2019)

More data for this
Ligand-Target Pair
5'-nucleotidase


(Homo sapiens (Human))
BDBM420000
PNG
(US10472364, Compound 73)
Show SMILES CN1[O]=C(CC(OC[C@H]2O[C@H]([C@@H](F)[C@@H]2O)n2cnc3c(N)nc(Cl)nc23)(C(O)=O)C(O)=O)C=C1C(O)=O
Show InChI InChI=1S/C19H19ClFN6O10/c1-26-7(15(29)30)2-6(37-26)3-19(16(31)32,17(33)34)35-4-8-11(28)9(21)14(36-8)27-5-23-10-12(22)24-18(20)25-13(10)27/h2,5,8-9,11,14,28H,3-4H2,1H3,(H,29,30)(H,31,32)(H,33,34)(H2,22,24,25)/t8-,9+,11-,14-/m1/s1
PDB

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n/an/a 8.61E+3n/an/an/an/an/an/a



Calithera Biosciences, Inc.

US Patent


Assay Description
For measurements of soluble CD73 enzyme activity, recombinant CD73 was obtained from R&D Systems, Cat. No. 5795-EN-010. Serial dilutions of test comp...


US Patent US10472364 (2019)

More data for this
Ligand-Target Pair
5'-nucleotidase


(Homo sapiens (Human))
BDBM419940
PNG
(US10472364, Compound 26)
Show SMILES O[C@@H]1[C@@H](COC(C(O)=O)C(O)=O)O[C@H]([C@H]1F)n1cnc2c(NCc3ccccc3)nc(Cl)nc12
Show InChI InChI=1S/C20H19ClFN5O7/c21-20-25-15(23-6-9-4-2-1-3-5-9)12-16(26-20)27(8-24-12)17-11(22)13(28)10(34-17)7-33-14(18(29)30)19(31)32/h1-5,8,10-11,13-14,17,28H,6-7H2,(H,29,30)(H,31,32)(H,23,25,26)/t10-,11+,13-,17-/m1/s1
PDB

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n/an/a 8.78E+3n/an/an/an/an/an/a



Calithera Biosciences, Inc.

US Patent


Assay Description
For measurements of soluble CD73 enzyme activity, recombinant CD73 was obtained from R&D Systems, Cat. No. 5795-EN-010. Serial dilutions of test comp...


US Patent US10472364 (2019)

More data for this
Ligand-Target Pair
5'-nucleotidase


(Homo sapiens (Human))
BDBM419914
PNG
(US10472364, Compound 1 | US10472364, Compound 2)
Show SMILES CCOC(=O)C(OC[C@H]1O[C@H]([C@@H](F)[C@@H]1O)n1cnc2c(N)nc(Cl)nc12)P(O)(O)=O
Show InChI InChI=1S/C14H18ClFN5O8P/c1-2-27-12(23)13(30(24,25)26)28-3-5-8(22)6(16)11(29-5)21-4-18-7-9(17)19-14(15)20-10(7)21/h4-6,8,11,13,22H,2-3H2,1H3,(H2,17,19,20)(H2,24,25,26)/t5-,6+,8-,11-,13?/m1/s1
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n/an/a 8.91E+3n/an/an/an/an/an/a



Calithera Biosciences, Inc.

US Patent


Assay Description
For measurements of soluble CD73 enzyme activity, recombinant CD73 was obtained from R&D Systems, Cat. No. 5795-EN-010. Serial dilutions of test comp...


US Patent US10472364 (2019)

More data for this
Ligand-Target Pair
5'-nucleotidase


(Homo sapiens (Human))
BDBM419943
PNG
(US10472364, Compound 29)
Show SMILES CNC(=O)C(OC[C@H]1O[C@H]([C@@H](F)[C@@H]1O)n1cnc2c(N)nc(Cl)nc12)P(O)(O)=O
Show InChI InChI=1S/C13H17ClFN6O7P/c1-17-10(23)12(29(24,25)26)27-2-4-7(22)5(15)11(28-4)21-3-18-6-8(16)19-13(14)20-9(6)21/h3-5,7,11-12,22H,2H2,1H3,(H,17,23)(H2,16,19,20)(H2,24,25,26)/t4-,5+,7-,11-,12?/m1/s1
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n/an/a 1.20E+4n/an/an/an/an/an/a



Calithera Biosciences, Inc.

US Patent


Assay Description
For measurements of soluble CD73 enzyme activity, recombinant CD73 was obtained from R&D Systems, Cat. No. 5795-EN-010. Serial dilutions of test comp...


US Patent US10472364 (2019)

More data for this
Ligand-Target Pair
5'-nucleotidase


(Homo sapiens (Human))
BDBM419919
PNG
(US10472364, Compound 5)
Show SMILES Nc1nc(Cl)nc2n(cnc12)[C@@H]1O[C@H](COC(C(O)=O)C(O)=O)[C@@H](O)[C@@H]1F
Show InChI InChI=1S/C13H13ClFN5O7/c14-13-18-8(16)5-9(19-13)20(2-17-5)10-4(15)6(21)3(27-10)1-26-7(11(22)23)12(24)25/h2-4,6-7,10,21H,1H2,(H,22,23)(H,24,25)(H2,16,18,19)/t3-,4+,6-,10-/m1/s1
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n/an/a 1.31E+4n/an/an/an/an/an/a



Calithera Biosciences, Inc.

US Patent


Assay Description
For measurements of soluble CD73 enzyme activity, recombinant CD73 was obtained from R&D Systems, Cat. No. 5795-EN-010. Serial dilutions of test comp...


US Patent US10472364 (2019)

More data for this
Ligand-Target Pair
5'-nucleotidase


(Homo sapiens (Human))
BDBM419924
PNG
(US10472364, Compound 10)
Show SMILES Nc1ncnc2n(cnc12)[C@@H]1O[C@H](COC(Cc2ccccc2)(C(O)=O)C(O)=O)[C@@H](O)[C@H]1F
Show InChI InChI=1S/C20H20FN5O7/c21-12-14(27)11(33-17(12)26-9-25-13-15(22)23-8-24-16(13)26)7-32-20(18(28)29,19(30)31)6-10-4-2-1-3-5-10/h1-5,8-9,11-12,14,17,27H,6-7H2,(H,28,29)(H,30,31)(H2,22,23,24)/t11-,12-,14-,17-/m1/s1
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n/an/a 2.16E+4n/an/an/an/an/an/a



Calithera Biosciences, Inc.

US Patent


Assay Description
For measurements of soluble CD73 enzyme activity, recombinant CD73 was obtained from R&D Systems, Cat. No. 5795-EN-010. Serial dilutions of test comp...


US Patent US10472364 (2019)

More data for this
Ligand-Target Pair
5'-nucleotidase


(Homo sapiens (Human))
BDBM419969
PNG
(US10472364, Compound 52)
Show SMILES Nc1nc(Cl)nc2n(cnc12)[C@@H]1O[C@H](COC(C(O)=O)C(O)=O)[C@@H](N=[N+]=[N-])[C@H]1O
Show InChI InChI=1S/C13H13ClN8O7/c14-13-18-8(15)5-9(19-13)22(2-17-5)10-6(23)4(20-21-16)3(29-10)1-28-7(11(24)25)12(26)27/h2-4,6-7,10,23H,1H2,(H,24,25)(H,26,27)(H2,15,18,19)/t3-,4-,6-,10-/m1/s1
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n/an/a>5.00E+4n/an/an/an/an/an/a



Calithera Biosciences, Inc.

US Patent


Assay Description
For measurements of soluble CD73 enzyme activity, recombinant CD73 was obtained from R&D Systems, Cat. No. 5795-EN-010. Serial dilutions of test comp...


US Patent US10472364 (2019)

More data for this
Ligand-Target Pair
5'-nucleotidase


(Homo sapiens (Human))
BDBM419923
PNG
(US10472364, Compound 9)
Show SMILES Nc1ncnc2n(cnc12)[C@@H]1O[C@H](COC(C(O)=O)C(O)=O)[C@@H](O)[C@H]1F
Show InChI InChI=1S/C13H14FN5O7/c14-5-7(20)4(1-25-8(12(21)22)13(23)24)26-11(5)19-3-18-6-9(15)16-2-17-10(6)19/h2-5,7-8,11,20H,1H2,(H,21,22)(H,23,24)(H2,15,16,17)/t4-,5-,7-,11-/m1/s1
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n/an/a>5.00E+4n/an/an/an/an/an/a



Calithera Biosciences, Inc.

US Patent


Assay Description
For measurements of soluble CD73 enzyme activity, recombinant CD73 was obtained from R&D Systems, Cat. No. 5795-EN-010. Serial dilutions of test comp...


US Patent US10472364 (2019)

More data for this
Ligand-Target Pair
5'-nucleotidase


(Homo sapiens (Human))
BDBM419944
PNG
(US10472364, Compound 31)
Show SMILES Nc1nc(Cl)nc2n(cnc12)[C@@H]1O[C@H](COC(CC(O)=O)C(O)=O)[C@@H](O)[C@@H]1F
Show InChI InChI=1S/C14H15ClFN5O7/c15-14-19-10(17)8-11(20-14)21(3-18-8)12-7(16)9(24)5(28-12)2-27-4(13(25)26)1-6(22)23/h3-5,7,9,12,24H,1-2H2,(H,22,23)(H,25,26)(H2,17,19,20)/t4?,5-,7+,9-,12-/m1/s1
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n/an/a>5.00E+4n/an/an/an/an/an/a



Calithera Biosciences, Inc.

US Patent


Assay Description
For measurements of soluble CD73 enzyme activity, recombinant CD73 was obtained from R&D Systems, Cat. No. 5795-EN-010. Serial dilutions of test comp...


US Patent US10472364 (2019)

More data for this
Ligand-Target Pair
5'-nucleotidase


(Homo sapiens (Human))
BDBM419927
PNG
(US10472364, Compound 14)
Show SMILES Cc1cn([C@H]2C[C@H](O)[C@@H](COCC(O)=O)O2)c(=O)[nH]c1=O
Show InChI InChI=1/C12H16N2O7/c1-6-3-14(12(19)13-11(6)18)9-2-7(15)8(21-9)4-20-5-10(16)17/h3,7-9,15H,2,4-5H2,1H3,(H,16,17)(H,13,18,19)/t7-,8+,9+/s2
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n/an/a>5.00E+4n/an/an/an/an/an/a



Calithera Biosciences, Inc.

US Patent


Assay Description
For measurements of soluble CD73 enzyme activity, recombinant CD73 was obtained from R&D Systems, Cat. No. 5795-EN-010. Serial dilutions of test comp...


US Patent US10472364 (2019)

More data for this
Ligand-Target Pair
5'-nucleotidase


(Homo sapiens (Human))
BDBM419974
PNG
(US10472364, Compound 55)
Show SMILES N[C@@H]1[C@H](O)[C@@H](COC(Cc2ccccc2)(C(O)=O)C(O)=O)O[C@H]1n1cnc2c(N)nc(Cl)nc12
Show InChI InChI=1S/C20H21ClN6O7/c21-19-25-14(23)12-15(26-19)27(8-24-12)16-11(22)13(28)10(34-16)7-33-20(17(29)30,18(31)32)6-9-4-2-1-3-5-9/h1-5,8,10-11,13,16,28H,6-7,22H2,(H,29,30)(H,31,32)(H2,23,25,26)/t10-,11-,13-,16-/m1/s1
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n/an/a>5.00E+4n/an/an/an/an/an/a



Calithera Biosciences, Inc.

US Patent


Assay Description
For measurements of soluble CD73 enzyme activity, recombinant CD73 was obtained from R&D Systems, Cat. No. 5795-EN-010. Serial dilutions of test comp...


US Patent US10472364 (2019)

More data for this
Ligand-Target Pair
5'-nucleotidase


(Homo sapiens (Human))
BDBM419925
PNG
(US10472364, Compound 11)
Show SMILES Nc1nc(Cl)nc2n(cnc12)[C@H]1C[C@H](O)[C@@H](COC(C(O)=O)C(O)=O)O1
Show InChI InChI=1S/C13H14ClN5O7/c14-13-17-9(15)7-10(18-13)19(3-16-7)6-1-4(20)5(26-6)2-25-8(11(21)22)12(23)24/h3-6,8,20H,1-2H2,(H,21,22)(H,23,24)(H2,15,17,18)/t4-,5+,6+/m0/s1
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n/an/a>5.00E+4n/an/an/an/an/an/a



Calithera Biosciences, Inc.

US Patent


Assay Description
For measurements of soluble CD73 enzyme activity, recombinant CD73 was obtained from R&D Systems, Cat. No. 5795-EN-010. Serial dilutions of test comp...


US Patent US10472364 (2019)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%