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Patent code US10472367

Compile Data Set for Download or QSAR
Found 5 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM98031
PNG
(US10472367, Compound Formula V | US8487096, V | US...)
Show SMILES CNC(=O)c1ccc(cc1C)-c1cnc2ncc(Cc3ccc4ncccc4c3)n2n1
Show InChI InChI=1S/C24H20N6O/c1-15-10-18(6-7-20(15)23(31)25-2)22-14-28-24-27-13-19(30(24)29-22)12-16-5-8-21-17(11-16)4-3-9-26-21/h3-11,13-14H,12H2,1-2H3,(H,25,31)
PDB
MMDB

KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 0.550n/an/an/an/an/an/a



INCYTE INCORPORATION; INCYTE HOLDINGS CORPORATION

US Patent


Assay Description
The compounds of the invention were screened in vitro for their ability to inhibit c-Met kinase activity. Briefly, histidine-tagged c-Met catalytic d...


US Patent US10472367 (2019)

More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM98028
PNG
(US10472367, Compound Formula II | US8487096, II | ...)
Show SMILES CNC(=O)c1ccc(cc1Cl)-c1cnc2ncc(Cc3ccc4ncccc4c3)n2n1
Show InChI InChI=1S/C23H17ClN6O/c1-25-22(31)18-6-5-16(11-19(18)24)21-13-28-23-27-12-17(30(23)29-21)10-14-4-7-20-15(9-14)3-2-8-26-20/h2-9,11-13H,10H2,1H3,(H,25,31)
PDB
MMDB

KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 0.550n/an/an/an/an/an/a



INCYTE INCORPORATION; INCYTE HOLDINGS CORPORATION

US Patent


Assay Description
The compounds of the invention were screened in vitro for their ability to inhibit c-Met kinase activity. Briefly, histidine-tagged c-Met catalytic d...


US Patent US10472367 (2019)

More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM98029
PNG
(US10472367, Compound Formula III | US8487096, III ...)
Show SMILES C[C@H](NC(=O)c1ccc(cc1Cl)-c1cnc2ncc(Cc3ccc4ncccc4c3)n2n1)c1noc(C)n1
Show InChI InChI=1/C27H21ClN8O2/c1-15(25-33-16(2)38-35-25)32-26(37)21-7-6-19(12-22(21)28)24-14-31-27-30-13-20(36(27)34-24)11-17-5-8-23-18(10-17)4-3-9-29-23/h3-10,12-15H,11H2,1-2H3,(H,32,37)/t15-/s2
PDB
MMDB

KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.550n/an/an/an/an/an/a



INCYTE INCORPORATION; INCYTE HOLDINGS CORPORATION

US Patent


Assay Description
The compounds of the invention were screened in vitro for their ability to inhibit c-Met kinase activity. Briefly, histidine-tagged c-Met catalytic d...


US Patent US10472367 (2019)

More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM98030
PNG
(US10472367, Compound Formula IV | US8487096, IV | ...)
Show SMILES CNC(=O)c1ccc(cn1)-c1cnc2ncc(Cc3ccc4ncccc4c3)n2n1
Show InChI InChI=1S/C22H17N7O/c1-23-21(30)19-7-5-16(11-25-19)20-13-27-22-26-12-17(29(22)28-20)10-14-4-6-18-15(9-14)3-2-8-24-18/h2-9,11-13H,10H2,1H3,(H,23,30)
PDB
MMDB

KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 0.550n/an/an/an/an/an/a



INCYTE INCORPORATION; INCYTE HOLDINGS CORPORATION

US Patent


Assay Description
The compounds of the invention were screened in vitro for their ability to inhibit c-Met kinase activity. Briefly, histidine-tagged c-Met catalytic d...


US Patent US10472367 (2019)

More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM98027
PNG
(US10472367, Compound Formula I | US8487096, I | US...)
Show SMILES C[C@@H](O)CNC(=O)c1ccc(cc1F)-c1cnc2ncc(Cc3ccc4ncccc4c3)n2n1
Show InChI InChI=1/C25H21FN6O2/c1-15(33)12-28-24(34)20-6-5-18(11-21(20)26)23-14-30-25-29-13-19(32(25)31-23)10-16-4-7-22-17(9-16)3-2-8-27-22/h2-9,11,13-15,33H,10,12H2,1H3,(H,28,34)/t15-/s2
PDB
MMDB

KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.550n/an/an/an/an/an/a



INCYTE INCORPORATION; INCYTE HOLDINGS CORPORATION

US Patent


Assay Description
The compounds of the invention were screened in vitro for their ability to inhibit c-Met kinase activity. Briefly, histidine-tagged c-Met catalytic d...


US Patent US10472367 (2019)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%