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Patent code US10479795

Compile Data Set for Download or QSAR

Found 816 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
PIK3CG/PIK3R1


(Homo sapiens (Human))
BDBM421147
PNG
(3-(4-aminoimidazo[2,1-f][1,2,4]triazin-7-yl)-N-(1-...)
Show SMILES Cc1ccc(cc1-c1cnc2c(N)ncnn12)S(=O)(=O)NC1(CC1)C#N
Show InChI InChI=1S/C16H15N7O2S/c1-10-2-3-11(26(24,25)22-16(8-17)4-5-16)6-12(10)13-7-19-15-14(18)20-9-21-23(13)15/h2-3,6-7,9,22H,4-5H2,1H3,(H2,18,20,21)
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n/an/a<100n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
PI3K-γ:[γ-33P]ATP (10 mCi/mL) and Wheat Germ Agglutinin (WGA) YSi SPA Scintillation Beads was purchased from Perkin-Elmer (Waltham, Mass.)....


US Patent US10479795 (2019)

More data for this
Ligand-Target Pair
PIK3CG/PIK3R1


(Homo sapiens (Human))
BDBM421153
PNG
(1-((3-(4-Aminoimidazo[2,1-f][1,2,4]triazin-7-yl)-4...)
Show SMILES Cc1ccc(cc1-c1cnc2c(N)ncnn12)S(=O)(=O)N1CCC(F)(F)C(O)C1
Show InChI InChI=1S/C17H18F2N6O3S/c1-10-2-3-11(29(27,28)24-5-4-17(18,19)14(26)8-24)6-12(10)13-7-21-16-15(20)22-9-23-25(13)16/h2-3,6-7,9,14,26H,4-5,8H2,1H3,(H2,20,22,23)
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n/an/a<100n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
PI3K-γ:[γ-33P]ATP (10 mCi/mL) and Wheat Germ Agglutinin (WGA) YSi SPA Scintillation Beads was purchased from Perkin-Elmer (Waltham, Mass.)....


US Patent US10479795 (2019)

More data for this
Ligand-Target Pair
PIK3CG/PIK3R1


(Homo sapiens (Human))
BDBM421173
PNG
(7-(2-methyl-5-((4-(pyridin-2-yl)piperidin-1- yl)su...)
Show SMILES Cc1ccc(cc1-c1cnc2c(N)ncnn12)S(=O)(=O)N1CCC(CC1)c1ccccn1
Show InChI InChI=1S/C22H23N7O2S/c1-15-5-6-17(12-18(15)20-13-25-22-21(23)26-14-27-29(20)22)32(30,31)28-10-7-16(8-11-28)19-4-2-3-9-24-19/h2-6,9,12-14,16H,7-8,10-11H2,1H3,(H2,23,26,27)
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Incyte Corporation

US Patent


Assay Description
PI3K-γ:[γ-33P]ATP (10 mCi/mL) and Wheat Germ Agglutinin (WGA) YSi SPA Scintillation Beads was purchased from Perkin-Elmer (Waltham, Mass.)....


US Patent US10479795 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM421174
PNG
(1-((3-(4-aminoimidazo[2,1-f][1,2,4]triazin-7-yl)-4...)
Show SMILES Cc1ccc(cc1-c1cnc2c(N)ncnn12)S(=O)(=O)N1CCC(CC1)C#N
Show InChI InChI=1S/C18H19N7O2S/c1-12-2-3-14(28(26,27)24-6-4-13(9-19)5-7-24)8-15(12)16-10-21-18-17(20)22-11-23-25(16)18/h2-3,8,10-11,13H,4-7H2,1H3,(H2,20,22,23)
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Incyte Corporation

US Patent


Assay Description
PI3Kδ:[γ-33P]ATP (10 mCi/mL) and Wheat Germ Agglutinin (WGA) YSi SPA Scintillation Beads was purchased from Perkin-Elmer (Waltham, Mass.). ...


US Patent US10479795 (2019)

More data for this
Ligand-Target Pair
PIK3CG/PIK3R1


(Homo sapiens (Human))
BDBM421181
PNG
(7-(2-methyl-5-((3,4,6,7-tetrahydro-5H-imidazo[4,5-...)
Show SMILES Cc1ccc(cc1-c1cnc2c(N)ncnn12)S(=O)(=O)N1CCc2nc[nH]c2C1
Show InChI InChI=1S/C18H18N8O2S/c1-11-2-3-12(29(27,28)25-5-4-14-15(8-25)22-9-21-14)6-13(11)16-7-20-18-17(19)23-10-24-26(16)18/h2-3,6-7,9-10H,4-5,8H2,1H3,(H,21,22)(H2,19,23,24)
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Incyte Corporation

US Patent


Assay Description
PI3K-γ:[γ-33P]ATP (10 mCi/mL) and Wheat Germ Agglutinin (WGA) YSi SPA Scintillation Beads was purchased from Perkin-Elmer (Waltham, Mass.)....


US Patent US10479795 (2019)

More data for this
Ligand-Target Pair
PIK3CG/PIK3R1


(Homo sapiens (Human))
BDBM421182
PNG
(7-(2-methyl-5-((2-methyl-2,4,6,7-tetrahydro-5H- py...)
Show SMILES Cc1ccc(cc1-c1cnc2c(N)ncnn12)S(=O)(=O)N1CCc2nn(C)cc2C1
Show InChI InChI=1S/C19H20N8O2S/c1-12-3-4-14(7-15(12)17-8-21-19-18(20)22-11-23-27(17)19)30(28,29)26-6-5-16-13(10-26)9-25(2)24-16/h3-4,7-9,11H,5-6,10H2,1-2H3,(H2,20,22,23)
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Incyte Corporation

US Patent


Assay Description
PI3K-γ:[γ-33P]ATP (10 mCi/mL) and Wheat Germ Agglutinin (WGA) YSi SPA Scintillation Beads was purchased from Perkin-Elmer (Waltham, Mass.)....


US Patent US10479795 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM421183
PNG
(N-(1-((3-(4-aminoimidazo[2,1-f][1,2,4]triazin-7-yl...)
Show SMILES CC(=O)NC1CCN(CC1)S(=O)(=O)c1ccc(C)c(c1)-c1cnc2c(N)ncnn12
Show InChI InChI=1S/C19H23N7O3S/c1-12-3-4-15(30(28,29)25-7-5-14(6-8-25)24-13(2)27)9-16(12)17-10-21-19-18(20)22-11-23-26(17)19/h3-4,9-11,14H,5-8H2,1-2H3,(H,24,27)(H2,20,22,23)
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Incyte Corporation

US Patent


Assay Description
PI3Kδ:[γ-33P]ATP (10 mCi/mL) and Wheat Germ Agglutinin (WGA) YSi SPA Scintillation Beads was purchased from Perkin-Elmer (Waltham, Mass.). ...


US Patent US10479795 (2019)

More data for this
Ligand-Target Pair
PIK3CG/PIK3R1


(Homo sapiens (Human))
BDBM421184
PNG
(1-((3-(4-aminoimidazo[2,1-f][1,2,4]triazin-7-yl)-4...)
Show SMILES CNC(=O)C1CCN(CC1)S(=O)(=O)c1ccc(C)c(c1)-c1cnc2c(N)ncnn12
Show InChI InChI=1S/C19H23N7O3S/c1-12-3-4-14(30(28,29)25-7-5-13(6-8-25)19(27)21-2)9-15(12)16-10-22-18-17(20)23-11-24-26(16)18/h3-4,9-11,13H,5-8H2,1-2H3,(H,21,27)(H2,20,23,24)
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Incyte Corporation

US Patent


Assay Description
PI3K-γ:[γ-33P]ATP (10 mCi/mL) and Wheat Germ Agglutinin (WGA) YSi SPA Scintillation Beads was purchased from Perkin-Elmer (Waltham, Mass.)....


US Patent US10479795 (2019)

More data for this
Ligand-Target Pair
PIK3CG/PIK3R1


(Homo sapiens (Human))
BDBM421189
PNG
(6-(4-((3-(4-aminoimidazo[2,1-f][1,2,4]triazin-7-yl...)
Show SMILES Cc1ccc(cc1-c1cnc2c(N)ncnn12)S(=O)(=O)N1CCN(CC1)c1ccc(cn1)C#N
Show InChI InChI=1S/C22H21N9O2S/c1-15-2-4-17(10-18(15)19-13-26-22-21(24)27-14-28-31(19)22)34(32,33)30-8-6-29(7-9-30)20-5-3-16(11-23)12-25-20/h2-5,10,12-14H,6-9H2,1H3,(H2,24,27,28)
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Incyte Corporation

US Patent


Assay Description
PI3K-γ:[γ-33P]ATP (10 mCi/mL) and Wheat Germ Agglutinin (WGA) YSi SPA Scintillation Beads was purchased from Perkin-Elmer (Waltham, Mass.)....


US Patent US10479795 (2019)

More data for this
Ligand-Target Pair
PIK3CG/PIK3R1


(Homo sapiens (Human))
BDBM421192
PNG
(3-(4-aminoimidazo[2,1-f][1,2,4]triazin-7-yl)-4-met...)
Show SMILES Cc1ccc(cc1-c1cnc2c(N)ncnn12)S(=O)(=O)NCc1cccc(n1)C(F)(F)F
Show InChI InChI=1S/C19H16F3N7O2S/c1-11-5-6-13(7-14(11)15-9-24-18-17(23)25-10-26-29(15)18)32(30,31)27-8-12-3-2-4-16(28-12)19(20,21)22/h2-7,9-10,27H,8H2,1H3,(H2,23,25,26)
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Incyte Corporation

US Patent


Assay Description
PI3K-γ:[γ-33P]ATP (10 mCi/mL) and Wheat Germ Agglutinin (WGA) YSi SPA Scintillation Beads was purchased from Perkin-Elmer (Waltham, Mass.)....


US Patent US10479795 (2019)

More data for this
Ligand-Target Pair
PIK3CG/PIK3R1


(Homo sapiens (Human))
BDBM421200
PNG
(N-(5-((3-(4-aminoimidazo[2,1-f][1,2,4]triazin-7-yl...)
Show SMILES CC(=O)Nc1ccc(NS(=O)(=O)c2ccc(C)c(c2)-c2cnc3c(N)ncnn23)cn1
Show InChI InChI=1S/C19H18N8O3S/c1-11-3-5-14(7-15(11)16-9-22-19-18(20)23-10-24-27(16)19)31(29,30)26-13-4-6-17(21-8-13)25-12(2)28/h3-10,26H,1-2H3,(H2,20,23,24)(H,21,25,28)
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Incyte Corporation

US Patent


Assay Description
PI3K-γ:[γ-33P]ATP (10 mCi/mL) and Wheat Germ Agglutinin (WGA) YSi SPA Scintillation Beads was purchased from Perkin-Elmer (Waltham, Mass.)....


US Patent US10479795 (2019)

More data for this
Ligand-Target Pair
PIK3CG/PIK3R1


(Homo sapiens (Human))
BDBM421202
PNG
(3-(4-aminoimidazo[2,1-f][1,2,4]triazin-7-yl)-N-(6-...)
Show SMILES COc1ccc(NS(=O)(=O)c2ccc(C)c(c2)-c2cnc3c(N)ncnn23)c(C)n1
Show InChI InChI=1S/C19H19N7O3S/c1-11-4-5-13(30(27,28)25-15-6-7-17(29-3)24-12(15)2)8-14(11)16-9-21-19-18(20)22-10-23-26(16)19/h4-10,25H,1-3H3,(H2,20,22,23)
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Incyte Corporation

US Patent


Assay Description
PI3K-γ:[γ-33P]ATP (10 mCi/mL) and Wheat Germ Agglutinin (WGA) YSi SPA Scintillation Beads was purchased from Perkin-Elmer (Waltham, Mass.)....


US Patent US10479795 (2019)

More data for this
Ligand-Target Pair
PIK3CG/PIK3R1


(Homo sapiens (Human))
BDBM421203
PNG
(3-(4-aminoimidazo[2,1-f][1,2,4]triazin-7-yl)-N-(2-...)
Show SMILES Cc1ccc(cc1-c1cnc2c(N)ncnn12)S(=O)(=O)Nc1ccnc(c1)C#N
Show InChI InChI=1S/C18H14N8O2S/c1-11-2-3-14(29(27,28)25-12-4-5-21-13(6-12)8-19)7-15(11)16-9-22-18-17(20)23-10-24-26(16)18/h2-7,9-10H,1H3,(H,21,25)(H2,20,23,24)
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Incyte Corporation

US Patent


Assay Description
PI3K-γ:[γ-33P]ATP (10 mCi/mL) and Wheat Germ Agglutinin (WGA) YSi SPA Scintillation Beads was purchased from Perkin-Elmer (Waltham, Mass.)....


US Patent US10479795 (2019)

More data for this
Ligand-Target Pair
PIK3CG/PIK3R1


(Homo sapiens (Human))
BDBM421206
PNG
(US10479795, Example 251)
Show SMILES Cc1ccc(cc1-c1cnc2c(N)ncnn12)S(=O)(=O)NC12CC(C1)(CC2)C#N
Show InChI InChI=1S/C19H19N7O2S/c1-12-2-3-13(29(27,28)25-19-5-4-18(8-19,9-19)10-20)6-14(12)15-7-22-17-16(21)23-11-24-26(15)17/h2-3,6-7,11,25H,4-5,8-9H2,1H3,(H2,21,23,24)
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Incyte Corporation

US Patent


Assay Description
PI3K-γ:[γ-33P]ATP (10 mCi/mL) and Wheat Germ Agglutinin (WGA) YSi SPA Scintillation Beads was purchased from Perkin-Elmer (Waltham, Mass.)....


US Patent US10479795 (2019)

More data for this
Ligand-Target Pair
PIK3CG/PIK3R1


(Homo sapiens (Human))
BDBM421212
PNG
(US10479795, Example 257)
Show SMILES Cc1ncc(cc1-c1cnc2c(N)nc(cn12)C(F)(F)F)S(=O)(=O)NC12CC(C1)(CC2)C#N
Show InChI InChI=1S/C20H18F3N7O2S/c1-11-13(14-6-27-17-16(25)28-15(7-30(14)17)20(21,22)23)4-12(5-26-11)33(31,32)29-19-3-2-18(8-19,9-19)10-24/h4-7,29H,2-3,8-9H2,1H3,(H2,25,28)
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Incyte Corporation

US Patent


Assay Description
PI3K-γ:[γ-33P]ATP (10 mCi/mL) and Wheat Germ Agglutinin (WGA) YSi SPA Scintillation Beads was purchased from Perkin-Elmer (Waltham, Mass.)....


US Patent US10479795 (2019)

More data for this
Ligand-Target Pair
PIK3CG/PIK3R1


(Homo sapiens (Human))
BDBM421224
PNG
(3-(3-(8-Amino-6-(trifluoromethyl)imidazo[1,2-a]pyr...)
Show SMILES Cc1ccc(cc1-c1cnc2c(N)nc(cn12)C(F)(F)F)S(=O)(=O)NC12CC(C1)(C2)C(O)=O
Show InChI InChI=1S/C20H18F3N5O4S/c1-10-2-3-11(33(31,32)27-19-7-18(8-19,9-19)17(29)30)4-12(10)13-5-25-16-15(24)26-14(6-28(13)16)20(21,22)23/h2-6,27H,7-9H2,1H3,(H2,24,26)(H,29,30)
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Incyte Corporation

US Patent


Assay Description
PI3K-γ:[γ-33P]ATP (10 mCi/mL) and Wheat Germ Agglutinin (WGA) YSi SPA Scintillation Beads was purchased from Perkin-Elmer (Waltham, Mass.)....


US Patent US10479795 (2019)

More data for this
Ligand-Target Pair
PIK3CG/PIK3R1


(Homo sapiens (Human))
BDBM421232
PNG
(2-((3-(8-amino-6-(trifluoromethyl)imidazo[1,2-a]py...)
Show SMILES Cc1ccc(cc1-c1cnc2c(N)nc(cn12)C(F)(F)F)S(=O)(=O)N1CC2NCC1C2O
Show InChI InChI=1S/C19H19F3N6O3S/c1-9-2-3-10(32(30,31)28-7-12-16(29)14(28)6-24-12)4-11(9)13-5-25-18-17(23)26-15(8-27(13)18)19(20,21)22/h2-5,8,12,14,16,24,29H,6-7H2,1H3,(H2,23,26)
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Incyte Corporation

US Patent


Assay Description
PI3K-γ:[γ-33P]ATP (10 mCi/mL) and Wheat Germ Agglutinin (WGA) YSi SPA Scintillation Beads was purchased from Perkin-Elmer (Waltham, Mass.)....


US Patent US10479795 (2019)

More data for this
Ligand-Target Pair
PIK3CG/PIK3R1


(Homo sapiens (Human))
BDBM421250
PNG
(3-(5-((3-(4-amino-2-(trifluoromethyl)imidazo[2,1- ...)
Show SMILES Cc1ccc(cc1-c1cnc2c(N)nc(nn12)C(F)(F)F)S(=O)(=O)N1CC2C(O)C1CN2C1CCC(C1)C#N
Show InChI InChI=1S/C24H25F3N8O3S/c1-12-2-5-15(7-16(12)17-9-30-22-21(29)31-23(24(25,26)27)32-35(17)22)39(37,38)34-11-18-20(36)19(34)10-33(18)14-4-3-13(6-14)8-28/h2,5,7,9,13-14,18-20,36H,3-4,6,10-11H2,1H3,(H2,29,31,32)
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Incyte Corporation

US Patent


Assay Description
PI3K-γ:[γ-33P]ATP (10 mCi/mL) and Wheat Germ Agglutinin (WGA) YSi SPA Scintillation Beads was purchased from Perkin-Elmer (Waltham, Mass.)....


US Patent US10479795 (2019)

More data for this
Ligand-Target Pair
PIK3CG/PIK3R1


(Homo sapiens (Human))
BDBM421252
PNG
(2-(5-((3-(4-amino-2-(trifluoromethyl)imidazo[2,1- ...)
Show SMILES Cc1ccc(cc1-c1cnc2c(N)nc(nn12)C(F)(F)F)S(=O)(=O)N1CC2C(O)C1CN2C1CCCC1C#N
Show InChI InChI=1S/C24H25F3N8O3S/c1-12-5-6-14(7-15(12)17-9-30-22-21(29)31-23(24(25,26)27)32-35(17)22)39(37,38)34-11-18-20(36)19(34)10-33(18)16-4-2-3-13(16)8-28/h5-7,9,13,16,18-20,36H,2-4,10-11H2,1H3,(H2,29,31,32)
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Incyte Corporation

US Patent


Assay Description
PI3K-γ:[γ-33P]ATP (10 mCi/mL) and Wheat Germ Agglutinin (WGA) YSi SPA Scintillation Beads was purchased from Perkin-Elmer (Waltham, Mass.)....


US Patent US10479795 (2019)

More data for this
Ligand-Target Pair
PIK3CG/PIK3R1


(Homo sapiens (Human))
BDBM421254
PNG
(2-((3-(4-amino-2-(trifluoromethyl)imidazo[2,1- f][...)
Show SMILES Cc1ccc(cc1-c1cnc2c(N)nc(nn12)C(F)(F)F)S(=O)(=O)N1CC2NCC1C2O
Show InChI InChI=1S/C18H18F3N7O3S/c1-8-2-3-9(32(30,31)27-7-11-14(29)13(27)6-23-11)4-10(8)12-5-24-16-15(22)25-17(18(19,20)21)26-28(12)16/h2-5,11,13-14,23,29H,6-7H2,1H3,(H2,22,25,26)
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Incyte Corporation

US Patent


Assay Description
PI3K-γ:[γ-33P]ATP (10 mCi/mL) and Wheat Germ Agglutinin (WGA) YSi SPA Scintillation Beads was purchased from Perkin-Elmer (Waltham, Mass.)....


US Patent US10479795 (2019)

More data for this
Ligand-Target Pair
PIK3CG/PIK3R1


(Homo sapiens (Human))
BDBM421262
PNG
(5-(4-aminoimidazo[2,1-f][1,2,4]triazin-7-yl)-2-flu...)
Show SMILES CC1(O)CCC(CC1)NS(=O)(=O)c1cc(ccc1F)-c1cnc2c(N)ncnn12
Show InChI InChI=1S/C18H21FN6O3S/c1-18(26)6-4-12(5-7-18)24-29(27,28)15-8-11(2-3-13(15)19)14-9-21-17-16(20)22-10-23-25(14)17/h2-3,8-10,12,24,26H,4-7H2,1H3,(H2,20,22,23)
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Incyte Corporation

US Patent


Assay Description
PI3K-γ:[γ-33P]ATP (10 mCi/mL) and Wheat Germ Agglutinin (WGA) YSi SPA Scintillation Beads was purchased from Perkin-Elmer (Waltham, Mass.)....


US Patent US10479795 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM421263
PNG
(5-(4-aminoimidazo[2,1-f][1,2,4]triazin-7-yl)-2-chl...)
Show SMILES CC1(O)CCC(CC1)NS(=O)(=O)c1cc(ccc1Cl)-c1cnc2c(N)ncnn12
Show InChI InChI=1S/C18H21ClN6O3S/c1-18(26)6-4-12(5-7-18)24-29(27,28)15-8-11(2-3-13(15)19)14-9-21-17-16(20)22-10-23-25(14)17/h2-3,8-10,12,24,26H,4-7H2,1H3,(H2,20,22,23)
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Incyte Corporation

US Patent


Assay Description
PI3Kδ:[γ-33P]ATP (10 mCi/mL) and Wheat Germ Agglutinin (WGA) YSi SPA Scintillation Beads was purchased from Perkin-Elmer (Waltham, Mass.). ...


US Patent US10479795 (2019)

More data for this
Ligand-Target Pair
PIK3CG/PIK3R1


(Homo sapiens (Human))
BDBM421278
PNG
(3-(8-Amino-6-(trifluoromethyl)imidazo[1,2- a]pyraz...)
Show SMILES Nc1nc(cn2c(cnc12)-c1cccc(c1)S(=O)(=O)NC12CC(CO)(C1)CC2)C(F)(F)F
Show InChI InChI=1S/C20H20F3N5O3S/c21-20(22,23)15-8-28-14(7-25-17(28)16(24)26-15)12-2-1-3-13(6-12)32(30,31)27-19-5-4-18(9-19,10-19)11-29/h1-3,6-8,27,29H,4-5,9-11H2,(H2,24,26)
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Incyte Corporation

US Patent


Assay Description
PI3K-γ:[γ-33P]ATP (10 mCi/mL) and Wheat Germ Agglutinin (WGA) YSi SPA Scintillation Beads was purchased from Perkin-Elmer (Waltham, Mass.)....


US Patent US10479795 (2019)

More data for this
Ligand-Target Pair
PIK3CG/PIK3R1


(Homo sapiens (Human))
BDBM421284
PNG
(5-(8-Amino-6-(trifluoromethyl)imidazo[1,2- a]pyraz...)
Show SMILES Cc1cc(C)c(cc1-c1cnc2c(N)nc(cn12)C(F)(F)F)S(=O)(=O)NC12CC(CO)(C1)CC2
Show InChI InChI=1S/C22H24F3N5O3S/c1-12-5-13(2)16(34(32,33)29-21-4-3-20(9-21,10-21)11-31)6-14(12)15-7-27-19-18(26)28-17(8-30(15)19)22(23,24)25/h5-8,29,31H,3-4,9-11H2,1-2H3,(H2,26,28)
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Incyte Corporation

US Patent


Assay Description
PI3K-γ:[γ-33P]ATP (10 mCi/mL) and Wheat Germ Agglutinin (WGA) YSi SPA Scintillation Beads was purchased from Perkin-Elmer (Waltham, Mass.)....


US Patent US10479795 (2019)

More data for this
Ligand-Target Pair
PIK3CG/PIK3R1


(Homo sapiens (Human))
BDBM421290
PNG
((1-((3-(8-Amino-6-(trifluoromethyl)imidazo[1,2- a]...)
Show SMILES Cc1ccc(cc1-c1cnc2c(N)nc(cn12)C(F)(F)F)S(=O)(=O)N1CCCC(CO)C1
Show InChI InChI=1S/C20H22F3N5O3S/c1-12-4-5-14(32(30,31)27-6-2-3-13(9-27)11-29)7-15(12)16-8-25-19-18(24)26-17(10-28(16)19)20(21,22)23/h4-5,7-8,10,13,29H,2-3,6,9,11H2,1H3,(H2,24,26)
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Incyte Corporation

US Patent


Assay Description
PI3K-γ:[γ-33P]ATP (10 mCi/mL) and Wheat Germ Agglutinin (WGA) YSi SPA Scintillation Beads was purchased from Perkin-Elmer (Waltham, Mass.)....


US Patent US10479795 (2019)

More data for this
Ligand-Target Pair
PIK3CG/PIK3R1


(Homo sapiens (Human))
BDBM421296
PNG
(US10479795, Example 426)
Show SMILES Cc1ccc(cc1-c1cnc2c(N)nc(C)nn12)S(=O)(=O)NC12CC(C)(C1)OC2
Show InChI InChI=1S/C19H22N6O3S/c1-11-4-5-13(29(26,27)24-19-8-18(3,9-19)28-10-19)6-14(11)15-7-21-17-16(20)22-12(2)23-25(15)17/h4-7,24H,8-10H2,1-3H3,(H2,20,22,23)
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Incyte Corporation

US Patent


Assay Description
PI3K-γ:[γ-33P]ATP (10 mCi/mL) and Wheat Germ Agglutinin (WGA) YSi SPA Scintillation Beads was purchased from Perkin-Elmer (Waltham, Mass.)....


US Patent US10479795 (2019)

More data for this
Ligand-Target Pair
PIK3CG/PIK3R1


(Homo sapiens (Human))
BDBM421306
PNG
(US10479795, Example 436)
Show SMILES Cc1ccc(cc1-c1cnc2c(N)ncnn12)S(=O)(=O)NC12CCC(CC1)(OC2)C(F)F
Show InChI InChI=1S/C20H22F2N6O3S/c1-12-2-3-13(8-14(12)15-9-24-17-16(23)25-11-26-28(15)17)32(29,30)27-19-4-6-20(7-5-19,18(21)22)31-10-19/h2-3,8-9,11,18,27H,4-7,10H2,1H3,(H2,23,25,26)
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Incyte Corporation

US Patent


Assay Description
PI3K-γ:[γ-33P]ATP (10 mCi/mL) and Wheat Germ Agglutinin (WGA) YSi SPA Scintillation Beads was purchased from Perkin-Elmer (Waltham, Mass.)....


US Patent US10479795 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM421313
PNG
(US10479795, Example 443)
Show SMILES Cc1ccc(cc1-c1cnc2c(N)nc(C)nn12)S(=O)(=O)NC12CCC(O)(CC1)C2
Show InChI InChI=1S/C20H24N6O3S/c1-12-3-4-14(30(28,29)25-19-5-7-20(27,11-19)8-6-19)9-15(12)16-10-22-18-17(21)23-13(2)24-26(16)18/h3-4,9-10,25,27H,5-8,11H2,1-2H3,(H2,21,23,24)
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Incyte Corporation

US Patent


Assay Description
PI3Kδ:[γ-33P]ATP (10 mCi/mL) and Wheat Germ Agglutinin (WGA) YSi SPA Scintillation Beads was purchased from Perkin-Elmer (Waltham, Mass.). ...


US Patent US10479795 (2019)

More data for this
Ligand-Target Pair
PIK3CG/PIK3R1


(Homo sapiens (Human))
BDBM421336
PNG
(US10479795, Example 466)
Show SMILES Cc1c(F)cc(cc1-c1cnc2c(N)nc(nn12)C(F)(F)F)S(=O)(=O)N[C@H]1CC[C@H](CC#N)OC1
Show InChI InChI=1S/C20H19F4N7O3S/c1-10-14(16-8-27-18-17(26)28-19(20(22,23)24)29-31(16)18)6-13(7-15(10)21)35(32,33)30-11-2-3-12(4-5-25)34-9-11/h6-8,11-12,30H,2-4,9H2,1H3,(H2,26,28,29)/t11-,12+/m0/s1
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Incyte Corporation

US Patent


Assay Description
PI3K-γ:[γ-33P]ATP (10 mCi/mL) and Wheat Germ Agglutinin (WGA) YSi SPA Scintillation Beads was purchased from Perkin-Elmer (Waltham, Mass.)....


US Patent US10479795 (2019)

More data for this
Ligand-Target Pair
PIK3CG/PIK3R1


(Homo sapiens (Human))
BDBM421343
PNG
(US10479795, Example 473)
Show SMILES Cc1ccc(cc1-c1cnc2c(N)nc(cn12)-c1ccncc1C)S(C)(=O)=O
Show InChI InChI=1S/C20H19N5O2S/c1-12-4-5-14(28(3,26)27)8-16(12)18-10-23-20-19(21)24-17(11-25(18)20)15-6-7-22-9-13(15)2/h4-11H,1-3H3,(H2,21,24)
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Incyte Corporation

US Patent


Assay Description
PI3K-γ:[γ-33P]ATP (10 mCi/mL) and Wheat Germ Agglutinin (WGA) YSi SPA Scintillation Beads was purchased from Perkin-Elmer (Waltham, Mass.)....


US Patent US10479795 (2019)

More data for this
Ligand-Target Pair
PIK3CG/PIK3R1


(Homo sapiens (Human))
BDBM421355
PNG
(6-(3-Methoxypyridin-4-yl)-3-(2-methyl-5- (methylsu...)
Show SMILES COc1cnccc1-c1cn2c(cnc2c(N)n1)-c1cc(ccc1C)S(C)(=O)=O
Show InChI InChI=1S/C20H19N5O3S/c1-12-4-5-13(29(3,26)27)8-15(12)17-9-23-20-19(21)24-16(11-25(17)20)14-6-7-22-10-18(14)28-2/h4-11H,1-3H3,(H2,21,24)
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Incyte Corporation

US Patent


Assay Description
PI3K-γ:[γ-33P]ATP (10 mCi/mL) and Wheat Germ Agglutinin (WGA) YSi SPA Scintillation Beads was purchased from Perkin-Elmer (Waltham, Mass.)....


US Patent US10479795 (2019)

More data for this
Ligand-Target Pair
PIK3CG/PIK3R1


(Homo sapiens (Human))
BDBM421364
PNG
(US10479795, Example 494)
Show SMILES CC(O)CCS(=O)(=O)c1ccc(C)c(c1)-c1cnc2c(N)nc(cn12)C(F)(F)F
Show InChI InChI=1S/C18H19F3N4O3S/c1-10-3-4-12(29(27,28)6-5-11(2)26)7-13(10)14-8-23-17-16(22)24-15(9-25(14)17)18(19,20)21/h3-4,7-9,11,26H,5-6H2,1-2H3,(H2,22,24)
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Incyte Corporation

US Patent


Assay Description
PI3K-γ:[γ-33P]ATP (10 mCi/mL) and Wheat Germ Agglutinin (WGA) YSi SPA Scintillation Beads was purchased from Perkin-Elmer (Waltham, Mass.)....


US Patent US10479795 (2019)

More data for this
Ligand-Target Pair
PIK3CG/PIK3R1


(Homo sapiens (Human))
BDBM421370
PNG
(7-(5-(((3,3-Difluorocyclobutyl)methyl)sulfonyl)-2-...)
Show SMILES Cc1ccc(cc1-c1cnc2c(N)ncnn12)S(=O)(=O)CC1CC(F)(F)C1
Show InChI InChI=1S/C17H17F2N5O2S/c1-10-2-3-12(27(25,26)8-11-5-17(18,19)6-11)4-13(10)14-7-21-16-15(20)22-9-23-24(14)16/h2-4,7,9,11H,5-6,8H2,1H3,(H2,20,22,23)
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Incyte Corporation

US Patent


Assay Description
PI3K-γ:[γ-33P]ATP (10 mCi/mL) and Wheat Germ Agglutinin (WGA) YSi SPA Scintillation Beads was purchased from Perkin-Elmer (Waltham, Mass.)....


US Patent US10479795 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM421373
PNG
(US10479795, Example 503)
Show SMILES Cc1ccc(cc1-c1cnc2c(N)nc(cn12)-c1ccncc1F)S(=O)(=O)CC1(O)CCC1
Show InChI InChI=1S/C23H22FN5O3S/c1-14-3-4-15(33(31,32)13-23(30)6-2-7-23)9-17(14)20-11-27-22-21(25)28-19(12-29(20)22)16-5-8-26-10-18(16)24/h3-5,8-12,30H,2,6-7,13H2,1H3,(H2,25,28)
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Incyte Corporation

US Patent


Assay Description
PI3Kδ:[γ-33P]ATP (10 mCi/mL) and Wheat Germ Agglutinin (WGA) YSi SPA Scintillation Beads was purchased from Perkin-Elmer (Waltham, Mass.). ...


US Patent US10479795 (2019)

More data for this
Ligand-Target Pair
PIK3CG/PIK3R1


(Homo sapiens (Human))
BDBM421377
PNG
(US10479795, Example 507)
Show SMILES Cc1ccc(cc1-c1cnc2c(N)ncnn12)S(=O)(=O)N[C@H]1CC[C@@](C)(O)CC1
Show InChI InChI=1S/C19H24N6O3S/c1-12-3-4-14(29(27,28)24-13-5-7-19(2,26)8-6-13)9-15(12)16-10-21-18-17(20)22-11-23-25(16)18/h3-4,9-11,13,24,26H,5-8H2,1-2H3,(H2,20,22,23)/t13-,19+
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Incyte Corporation

US Patent


Assay Description
PI3K-γ:[γ-33P]ATP (10 mCi/mL) and Wheat Germ Agglutinin (WGA) YSi SPA Scintillation Beads was purchased from Perkin-Elmer (Waltham, Mass.)....


US Patent US10479795 (2019)

More data for this
Ligand-Target Pair
PIK3CG/PIK3R1


(Homo sapiens (Human))
BDBM421378
PNG
(US10479795, Example 508)
Show SMILES Cc1ccc(cc1-c1cnc2c(N)ncnn12)S(=O)(=O)N[C@H]1CC[C@](C)(O)CC1
Show InChI InChI=1S/C19H24N6O3S/c1-12-3-4-14(29(27,28)24-13-5-7-19(2,26)8-6-13)9-15(12)16-10-21-18-17(20)22-11-23-25(16)18/h3-4,9-11,13,24,26H,5-8H2,1-2H3,(H2,20,22,23)/t13-,19-
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Incyte Corporation

US Patent


Assay Description
PI3K-γ:[γ-33P]ATP (10 mCi/mL) and Wheat Germ Agglutinin (WGA) YSi SPA Scintillation Beads was purchased from Perkin-Elmer (Waltham, Mass.)....


US Patent US10479795 (2019)

More data for this
Ligand-Target Pair
PIK3CG/PIK3R1


(Homo sapiens (Human))
BDBM421005
PNG
(3-(8-Amino-6-pyrimidin-5-ylimidazo[1,2-a]pyridin-3...)
Show SMILES Cc1ccc(cc1-c1cnc2c(N)cc(cn12)-c1cncnc1)S(=O)(=O)N[C@H]1CC[C@H](O)CC1
Show InChI InChI=1S/C24H26N6O3S/c1-15-2-7-20(34(32,33)29-18-3-5-19(31)6-4-18)9-21(15)23-12-28-24-22(25)8-16(13-30(23)24)17-10-26-14-27-11-17/h2,7-14,18-19,29,31H,3-6,25H2,1H3/t18-,19-
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Incyte Corporation

US Patent


Assay Description
PI3K-γ:[γ-33P]ATP (10 mCi/mL) and Wheat Germ Agglutinin (WGA) YSi SPA Scintillation Beads was purchased from Perkin-Elmer (Waltham, Mass.)....


US Patent US10479795 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM421018
PNG
(3-[8-Amino-6-(3-fluorophenyl)imidazo[1,2-a]pyrazin...)
Show SMILES Cc1ccc(cc1-c1cnc2c(N)nc(cn12)-c1cccc(F)c1)S(=O)(=O)N[C@H]1CC[C@H](O)CC1
Show InChI InChI=1S/C25H26FN5O3S/c1-15-5-10-20(35(33,34)30-18-6-8-19(32)9-7-18)12-21(15)23-13-28-25-24(27)29-22(14-31(23)25)16-3-2-4-17(26)11-16/h2-5,10-14,18-19,30,32H,6-9H2,1H3,(H2,27,29)/t18-,19-
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Incyte Corporation

US Patent


Assay Description
PI3Kδ:[γ-33P]ATP (10 mCi/mL) and Wheat Germ Agglutinin (WGA) YSi SPA Scintillation Beads was purchased from Perkin-Elmer (Waltham, Mass.). ...


US Patent US10479795 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM421021
PNG
(3-[8-Amino-6-(4-cyanophenyl)imidazo[1,2-a]pyrazin-...)
Show SMILES Cc1ccc(cc1-c1cn2cc(nc(N)c2n1)-c1ccc(cc1)C#N)S(=O)(=O)N[C@H]1CC[C@H](O)CC1
Show InChI InChI=1S/C26H26N6O3S/c1-16-2-11-21(36(34,35)31-19-7-9-20(33)10-8-19)12-22(16)24-15-32-14-23(29-25(28)26(32)30-24)18-5-3-17(13-27)4-6-18/h2-6,11-12,14-15,19-20,31,33H,7-10H2,1H3,(H2,28,29)/t19-,20-
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Incyte Corporation

US Patent


Assay Description
PI3Kδ:[γ-33P]ATP (10 mCi/mL) and Wheat Germ Agglutinin (WGA) YSi SPA Scintillation Beads was purchased from Perkin-Elmer (Waltham, Mass.). ...


US Patent US10479795 (2019)

More data for this
Ligand-Target Pair
PIK3CG/PIK3R1


(Homo sapiens (Human))
BDBM421383
PNG
(US10479795, Example 513)
Show SMILES Cc1ccc(cc1-c1cnc2c(N)nc(cn12)C(F)(F)F)S(=O)(=O)N1CCCC(CN)C1
Show InChI InChI=1S/C20H23F3N6O2S/c1-12-4-5-14(32(30,31)28-6-2-3-13(8-24)10-28)7-15(12)16-9-26-19-18(25)27-17(11-29(16)19)20(21,22)23/h4-5,7,9,11,13H,2-3,6,8,10,24H2,1H3,(H2,25,27)
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Incyte Corporation

US Patent


Assay Description
PI3K-γ:[γ-33P]ATP (10 mCi/mL) and Wheat Germ Agglutinin (WGA) YSi SPA Scintillation Beads was purchased from Perkin-Elmer (Waltham, Mass.)....


US Patent US10479795 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM421391
PNG
(US10479795, Example 521)
Show SMILES CC(O)C12CC(C1)(CCC2)NS(=O)(=O)c1ccc(C)c(c1)-c1cnc2c(N)ncnn12
Show InChI InChI=1S/C21H26N6O3S/c1-13-4-5-15(8-16(13)17-9-23-19-18(22)24-12-25-27(17)19)31(29,30)26-21-7-3-6-20(10-21,11-21)14(2)28/h4-5,8-9,12,14,26,28H,3,6-7,10-11H2,1-2H3,(H2,22,24,25)
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Incyte Corporation

US Patent


Assay Description
PI3Kδ:[γ-33P]ATP (10 mCi/mL) and Wheat Germ Agglutinin (WGA) YSi SPA Scintillation Beads was purchased from Perkin-Elmer (Waltham, Mass.). ...


US Patent US10479795 (2019)

More data for this
Ligand-Target Pair
PIK3CG/PIK3R1


(Homo sapiens (Human))
BDBM421393
PNG
(US10479795, Example 523)
Show SMILES CN1CC2CC(C2)(C1)NS(=O)(=O)c1ccc(C)c(c1)-c1cnc2c(N)ncnn12
Show InChI InChI=1S/C19H23N7O2S/c1-12-3-4-14(29(27,28)24-19-6-13(7-19)9-25(2)10-19)5-15(12)16-8-21-18-17(20)22-11-23-26(16)18/h3-5,8,11,13,24H,6-7,9-10H2,1-2H3,(H2,20,22,23)
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Incyte Corporation

US Patent


Assay Description
PI3K-γ:[γ-33P]ATP (10 mCi/mL) and Wheat Germ Agglutinin (WGA) YSi SPA Scintillation Beads was purchased from Perkin-Elmer (Waltham, Mass.)....


US Patent US10479795 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM421395
PNG
(US10479795, Example 525)
Show SMILES Cc1ccc(cc1-c1cnc2c(N)ncnn12)S(=O)(=O)NC12CC(C1)CN(C2)C1CCC1
Show InChI InChI=1S/C22H27N7O2S/c1-14-5-6-17(7-18(14)19-10-24-21-20(23)25-13-26-29(19)21)32(30,31)27-22-8-15(9-22)11-28(12-22)16-3-2-4-16/h5-7,10,13,15-16,27H,2-4,8-9,11-12H2,1H3,(H2,23,25,26)
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Incyte Corporation

US Patent


Assay Description
PI3Kδ:[γ-33P]ATP (10 mCi/mL) and Wheat Germ Agglutinin (WGA) YSi SPA Scintillation Beads was purchased from Perkin-Elmer (Waltham, Mass.). ...


US Patent US10479795 (2019)

More data for this
Ligand-Target Pair
PIK3CG/PIK3R1


(Homo sapiens (Human))
BDBM421397
PNG
(US10479795, Example 527)
Show SMILES CC(C)N1CCCC(C)(C1)NS(=O)(=O)c1ccc(C)c(c1)-c1cnc2c(N)nc(nn12)C(F)(F)F
Show InChI InChI=1S/C22H28F3N7O2S/c1-13(2)31-9-5-8-21(4,12-31)30-35(33,34)15-7-6-14(3)16(10-15)17-11-27-19-18(26)28-20(22(23,24)25)29-32(17)19/h6-7,10-11,13,30H,5,8-9,12H2,1-4H3,(H2,26,28,29)
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Incyte Corporation

US Patent


Assay Description
PI3K-γ:[γ-33P]ATP (10 mCi/mL) and Wheat Germ Agglutinin (WGA) YSi SPA Scintillation Beads was purchased from Perkin-Elmer (Waltham, Mass.)....


US Patent US10479795 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM421397
PNG
(US10479795, Example 527)
Show SMILES CC(C)N1CCCC(C)(C1)NS(=O)(=O)c1ccc(C)c(c1)-c1cnc2c(N)nc(nn12)C(F)(F)F
Show InChI InChI=1S/C22H28F3N7O2S/c1-13(2)31-9-5-8-21(4,12-31)30-35(33,34)15-7-6-14(3)16(10-15)17-11-27-19-18(26)28-20(22(23,24)25)29-32(17)19/h6-7,10-11,13,30H,5,8-9,12H2,1-4H3,(H2,26,28,29)
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Incyte Corporation

US Patent


Assay Description
PI3Kδ:[γ-33P]ATP (10 mCi/mL) and Wheat Germ Agglutinin (WGA) YSi SPA Scintillation Beads was purchased from Perkin-Elmer (Waltham, Mass.). ...


US Patent US10479795 (2019)

More data for this
Ligand-Target Pair
PIK3CG/PIK3R1


(Homo sapiens (Human))
BDBM421026
PNG
(3-[8-Amino-6-(1-methyl-1H-pyrazol-4-yl)imidazo[1,2...)
Show SMILES Cc1ccc(cc1-c1cnc2c(N)nc(cn12)-c1cnn(C)c1)S(=O)(=O)N[C@H]1CC[C@H](O)CC1
Show InChI InChI=1S/C23H27N7O3S/c1-14-3-8-18(34(32,33)28-16-4-6-17(31)7-5-16)9-19(14)21-11-25-23-22(24)27-20(13-30(21)23)15-10-26-29(2)12-15/h3,8-13,16-17,28,31H,4-7H2,1-2H3,(H2,24,27)/t16-,17-
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Incyte Corporation

US Patent


Assay Description
PI3K-γ:[γ-33P]ATP (10 mCi/mL) and Wheat Germ Agglutinin (WGA) YSi SPA Scintillation Beads was purchased from Perkin-Elmer (Waltham, Mass.)....


US Patent US10479795 (2019)

More data for this
Ligand-Target Pair
PIK3CG/PIK3R1


(Homo sapiens (Human))
BDBM421034
PNG
(US10479795, Example 37)
Show SMILES Cc1cn2c(cnc2c(N)n1)-c1cc(ccc1C)S(=O)(=O)N[C@H]1CC[C@H](O)CC1
Show InChI InChI=1S/C20H25N5O3S/c1-12-3-8-16(29(27,28)24-14-4-6-15(26)7-5-14)9-17(12)18-10-22-20-19(21)23-13(2)11-25(18)20/h3,8-11,14-15,24,26H,4-7H2,1-2H3,(H2,21,23)/t14-,15-
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Incyte Corporation

US Patent


Assay Description
PI3K-γ:[γ-33P]ATP (10 mCi/mL) and Wheat Germ Agglutinin (WGA) YSi SPA Scintillation Beads was purchased from Perkin-Elmer (Waltham, Mass.)....


US Patent US10479795 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM421404
PNG
(US10479795, Example 534)
Show SMILES Cc1ccc(cc1-c1cnc2c(N)ncnn12)S(=O)(=O)NC12C3C4C1C1C2C3C41C#N
Show InChI InChI=1S/C21H17N7O2S/c1-8-2-3-9(4-10(8)11-5-24-19-18(23)25-7-26-28(11)19)31(29,30)27-21-15-12-16(21)14-17(21)13(15)20(12,14)6-22/h2-5,7,12-17,27H,1H3,(H2,23,25,26)
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Incyte Corporation

US Patent


Assay Description
PI3Kδ:[γ-33P]ATP (10 mCi/mL) and Wheat Germ Agglutinin (WGA) YSi SPA Scintillation Beads was purchased from Perkin-Elmer (Waltham, Mass.). ...


US Patent US10479795 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM421407
PNG
(US10479795, Example 537)
Show SMILES CC(=O)N1CCC(CC1)c1cn2c(cnc2c(N)n1)-c1cc(ccc1C)S(C)(=O)=O
Show InChI InChI=1S/C21H25N5O3S/c1-13-4-5-16(30(3,28)29)10-17(13)19-11-23-21-20(22)24-18(12-26(19)21)15-6-8-25(9-7-15)14(2)27/h4-5,10-12,15H,6-9H2,1-3H3,(H2,22,24)
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Incyte Corporation

US Patent


Assay Description
PI3Kδ:[γ-33P]ATP (10 mCi/mL) and Wheat Germ Agglutinin (WGA) YSi SPA Scintillation Beads was purchased from Perkin-Elmer (Waltham, Mass.). ...


US Patent US10479795 (2019)

More data for this
Ligand-Target Pair
PIK3CG/PIK3R1


(Homo sapiens (Human))
BDBM421409
PNG
(US10479795, Example 539)
Show SMILES Cc1ccc(cc1-c1cnc2c(N)ncnn12)S(=O)(=O)Nc1ccc(nc1)C(=O)NCC(F)(F)F
Show InChI InChI=1S/C20H17F3N8O3S/c1-11-2-4-13(6-14(11)16-8-26-18-17(24)28-10-29-31(16)18)35(33,34)30-12-3-5-15(25-7-12)19(32)27-9-20(21,22)23/h2-8,10,30H,9H2,1H3,(H,27,32)(H2,24,28,29)
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Incyte Corporation

US Patent


Assay Description
PI3K-γ:[γ-33P]ATP (10 mCi/mL) and Wheat Germ Agglutinin (WGA) YSi SPA Scintillation Beads was purchased from Perkin-Elmer (Waltham, Mass.)....


US Patent US10479795 (2019)

More data for this
Ligand-Target Pair
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* indicates data uncertainty>20%