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Patent code US10485800

Compile Data Set for Download or QSAR

Found 204 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Mitogen-activated protein kinase kinase kinase 11


(Homo sapiens (Human))
BDBM50441569
PNG
(CHEMBL2436981 | US10485800, Example 4 | US9814704,...)
Show SMILES Nc1ccc(cn1)-c1cnc2[nH]cc(-c3ccc4[nH]ccc4c3)c2c1
Show InChI InChI=1S/C20H15N5/c21-19-4-2-14(9-23-19)15-8-16-17(11-25-20(16)24-10-15)12-1-3-18-13(7-12)5-6-22-18/h1-11,22H,(H2,21,23)(H,24,25)
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n/an/a<100n/an/an/an/an/an/a



The University of Rochester; Board of Regents of the University of Nebraska

US Patent


Assay Description
200 ng (130 nM) MLK3 (Dundee, DU8313) was incubated with 1 μM inactive MKK7b (Dundee, DU703) in the presence of 2 μM cold ATP (Km) and 0.5 ...


US Patent US10485800 (2019)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 11


(Homo sapiens (Human))
BDBM354762
PNG
(Preparation of 4-(2-(4-(7-(1H-indol-5-yl)-5H-pyrro...)
Show SMILES COc1cc(ccc1OCCN1CCOCC1)-c1cnc2[nH]cc(-c3ccc4[nH]ccc4c3)c2n1
Show InChI InChI=1S/C27H27N5O3/c1-33-25-15-19(3-5-24(25)35-13-10-32-8-11-34-12-9-32)23-17-30-27-26(31-23)21(16-29-27)18-2-4-22-20(14-18)6-7-28-22/h2-7,14-17,28H,8-13H2,1H3,(H,29,30)
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n/an/a<100n/an/an/an/an/an/a



The University of Rochester; Board of Regents of the University of Nebraska

US Patent


Assay Description
200 ng (130 nM) MLK3 (Dundee, DU8313) was incubated with 1 μM inactive MKK7b (Dundee, DU703) in the presence of 2 μM cold ATP (Km) and 0.5 ...


US Patent US10485800 (2019)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 11


(Homo sapiens (Human))
BDBM354782
PNG
(6-(3,5-difluoro-4- hydroxyphenyl)-1-(1H- indol-5-y...)
Show SMILES Oc1c(F)cc(cc1F)-c1cnc2[nH]c(=O)n(-c3ccc4[nH]ccc4c3)c2n1
Show InChI InChI=1S/C19H11F2N5O2/c20-12-6-10(7-13(21)16(12)27)15-8-23-17-18(24-15)26(19(28)25-17)11-1-2-14-9(5-11)3-4-22-14/h1-8,22,27H,(H,23,25,28)
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n/an/a<100n/an/an/an/an/an/a



The University of Rochester; Board of Regents of the University of Nebraska

US Patent


Assay Description
200 ng (130 nM) MLK3 (Dundee, DU8313) was incubated with 1 μM inactive MKK7b (Dundee, DU703) in the presence of 2 μM cold ATP (Km) and 0.5 ...


US Patent US10485800 (2019)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 11


(Homo sapiens (Human))
BDBM354872
PNG
(Preparation of 4-{5-[4-(piperazine-1-carbonyl)-phe...)
Show SMILES NC(=O)c1ccc(cc1)-c1c[nH]c2ncc(cc12)-c1ccc(cc1)C(=O)N1CC[NH2+]CC1
Show InChI InChI=1S/C25H23N5O2/c26-23(31)18-5-3-17(4-6-18)22-15-29-24-21(22)13-20(14-28-24)16-1-7-19(8-2-16)25(32)30-11-9-27-10-12-30/h1-8,13-15,27H,9-12H2,(H2,26,31)(H,28,29)/p+1
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n/an/a<100n/an/an/an/an/an/a



The University of Rochester; Board of Regents of the University of Nebraska

US Patent


Assay Description
200 ng (130 nM) MLK3 (Dundee, DU8313) was incubated with 1 μM inactive MKK7b (Dundee, DU703) in the presence of 2 μM cold ATP (Km) and 0.5 ...


US Patent US10485800 (2019)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 11


(Homo sapiens (Human))
BDBM420205
PNG
(US10485800, Cmpd ID FH | US10485800, Example 162)
Show SMILES CN1CCN(Cc2ccc(cc2)-c2c[nH]c3ncc(cc23)-c2ccc(cc2)C(N)=O)CC1
Show InChI InChI=1S/C26H27N5O/c1-30-10-12-31(13-11-30)17-18-2-4-20(5-3-18)24-16-29-26-23(24)14-22(15-28-26)19-6-8-21(9-7-19)25(27)32/h2-9,14-16H,10-13,17H2,1H3,(H2,27,32)(H,28,29)
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n/an/a<100n/an/an/an/an/an/a



The University of Rochester; Board of Regents of the University of Nebraska

US Patent


Assay Description
200 ng (130 nM) MLK3 (Dundee, DU8313) was incubated with 1 μM inactive MKK7b (Dundee, DU703) in the presence of 2 μM cold ATP (Km) and 0.5 ...


US Patent US10485800 (2019)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 11


(Homo sapiens (Human))
BDBM50441566
PNG
(CHEMBL2436977 | US10485800, Example 179)
Show SMILES CN1CCN(Cc2ccc(cc2)-c2cnc3[nH]cc(-c4cnc5[nH]ccc5c4)c3c2)CC1
Show InChI InChI=1S/C26H26N6/c1-31-8-10-32(11-9-31)17-18-2-4-19(5-3-18)21-13-23-24(16-30-26(23)29-14-21)22-12-20-6-7-27-25(20)28-15-22/h2-7,12-16H,8-11,17H2,1H3,(H,27,28)(H,29,30)
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n/an/a<100n/an/an/an/an/an/a



The University of Rochester; Board of Regents of the University of Nebraska

US Patent


Assay Description
200 ng (130 nM) MLK3 (Dundee, DU8313) was incubated with 1 μM inactive MKK7b (Dundee, DU703) in the presence of 2 μM cold ATP (Km) and 0.5 ...


US Patent US10485800 (2019)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 11


(Homo sapiens (Human))
BDBM420236
PNG
(US10485800, Cmpd ID GZ | US10485800, Example 203)
Show SMILES O=C(CC1CC1)N1CCN(Cc2ccc(cc2)-c2cnc3[nH]cc(-c4ccc5[nH]ccc5c4)c3c2)CC1
Show InChI InChI=1S/C31H29N5O/c37-30(15-21-1-2-21)36-13-11-35(12-14-36)20-22-3-5-23(6-4-22)26-17-27-28(19-34-31(27)33-18-26)24-7-8-29-25(16-24)9-10-32-29/h3-10,16-19,21H,1-2,11-15,20H2/b28-24+
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n/an/a<100n/an/an/an/an/an/a



The University of Rochester; Board of Regents of the University of Nebraska

US Patent


Assay Description
200 ng (130 nM) MLK3 (Dundee, DU8313) was incubated with 1 μM inactive MKK7b (Dundee, DU703) in the presence of 2 μM cold ATP (Km) and 0.5 ...


US Patent US10485800 (2019)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 11


(Homo sapiens (Human))
BDBM50441567
PNG
(CHEMBL2436978 | US10485800, Example 181)
Show SMILES CN1CCN(Cc2ccc(cc2)-c2cnc3[nH]cc(-c4ccc5[nH]ccc5c4)c3c2)CC1
Show InChI InChI=1S/C27H27N5/c1-31-10-12-32(13-11-31)18-19-2-4-20(5-3-19)23-15-24-25(17-30-27(24)29-16-23)21-6-7-26-22(14-21)8-9-28-26/h2-9,14-17,28H,10-13,18H2,1H3,(H,29,30)
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n/an/a<100n/an/an/an/an/an/a



The University of Rochester; Board of Regents of the University of Nebraska

US Patent


Assay Description
200 ng (130 nM) MLK3 (Dundee, DU8313) was incubated with 1 μM inactive MKK7b (Dundee, DU703) in the presence of 2 μM cold ATP (Km) and 0.5 ...


US Patent US10485800 (2019)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 11


(Homo sapiens (Human))
BDBM354739
PNG
(Preparation of N-(4-(5-(3,4,5-trimethoxyphenyl)-1H...)
Show SMILES COc1cc(cc(OC)c1OC)-c1cnc2[nH]cc(-c3ccc(NC(C)=O)cc3)c2c1
Show InChI InChI=1S/C24H23N3O4/c1-14(28)27-18-7-5-15(6-8-18)20-13-26-24-19(20)9-17(12-25-24)16-10-21(29-2)23(31-4)22(11-16)30-3/h5-13H,1-4H3,(H,25,26)(H,27,28)
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n/an/a<100n/an/an/an/an/an/a



The University of Rochester; Board of Regents of the University of Nebraska

US Patent


Assay Description
200 ng (130 nM) MLK3 (Dundee, DU8313) was incubated with 1 μM inactive MKK7b (Dundee, DU703) in the presence of 2 μM cold ATP (Km) and 0.5 ...


US Patent US10485800 (2019)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 11


(Homo sapiens (Human))
BDBM50441571
PNG
(CHEMBL2436982 | US10485800, Example 18 | US9814704...)
Show SMILES COc1cc(cc(OC)c1OC)-c1cnc2[nH]cc(-c3ccc(N)nc3)c2c1
Show InChI InChI=1S/C21H20N4O3/c1-26-17-7-13(8-18(27-2)20(17)28-3)14-6-15-16(11-25-21(15)24-10-14)12-4-5-19(22)23-9-12/h4-11H,1-3H3,(H2,22,23)(H,24,25)
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n/an/a<100n/an/an/an/an/an/a



The University of Rochester; Board of Regents of the University of Nebraska

US Patent


Assay Description
200 ng (130 nM) MLK3 (Dundee, DU8313) was incubated with 1 μM inactive MKK7b (Dundee, DU703) in the presence of 2 μM cold ATP (Km) and 0.5 ...


US Patent US10485800 (2019)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 11


(Homo sapiens (Human))
BDBM354747
PNG
(Preparation of 3-(1-methyl-1H-indol-5-yl)-5-(3,4,5...)
Show SMILES COc1cc(cc(OC)c1OC)-c1cnc2[nH]cc(-c3ccc4n(C)ccc4c3)c2c1
Show InChI InChI=1S/C25H23N3O3/c1-28-8-7-16-9-15(5-6-21(16)28)20-14-27-25-19(20)10-18(13-26-25)17-11-22(29-2)24(31-4)23(12-17)30-3/h5-14H,1-4H3,(H,26,27)
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n/an/a<100n/an/an/an/an/an/a



The University of Rochester; Board of Regents of the University of Nebraska

US Patent


Assay Description
200 ng (130 nM) MLK3 (Dundee, DU8313) was incubated with 1 μM inactive MKK7b (Dundee, DU703) in the presence of 2 μM cold ATP (Km) and 0.5 ...


US Patent US10485800 (2019)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 11


(Homo sapiens (Human))
BDBM354795
PNG
(1-(2-methyl-1H-indol-5-yl)- 6-(3,4,5-trimethoxyphe...)
Show SMILES COc1cc(cc(OC)c1OC)-c1cnc2[nH]c(=O)n(-c3ccc4[nH]c(C)cc4c3)c2n1
Show InChI InChI=1S/C23H21N5O4/c1-12-7-13-8-15(5-6-16(13)25-12)28-22-21(27-23(28)29)24-11-17(26-22)14-9-18(30-2)20(32-4)19(10-14)31-3/h5-11,25H,1-4H3,(H,24,27,29)
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n/an/a<100n/an/an/an/an/an/a



The University of Rochester; Board of Regents of the University of Nebraska

US Patent


Assay Description
200 ng (130 nM) MLK3 (Dundee, DU8313) was incubated with 1 μM inactive MKK7b (Dundee, DU703) in the presence of 2 μM cold ATP (Km) and 0.5 ...


US Patent US10485800 (2019)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 11


(Homo sapiens (Human))
BDBM354797
PNG
(1-cyclopentyl-6-(3,4,5- trimethoxy phenyl)-1H- imi...)
Show SMILES COc1cc(cc(OC)c1OC)-c1cnc2[nH]c(=O)n(C3CCCC3)c2n1
Show InChI InChI=1S/C19H22N4O4/c1-25-14-8-11(9-15(26-2)16(14)27-3)13-10-20-17-18(21-13)23(19(24)22-17)12-6-4-5-7-12/h8-10,12H,4-7H2,1-3H3,(H,20,22,24)
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n/an/a<100n/an/an/an/an/an/a



The University of Rochester; Board of Regents of the University of Nebraska

US Patent


Assay Description
200 ng (130 nM) MLK3 (Dundee, DU8313) was incubated with 1 μM inactive MKK7b (Dundee, DU703) in the presence of 2 μM cold ATP (Km) and 0.5 ...


US Patent US10485800 (2019)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 11


(Homo sapiens (Human))
BDBM354833
PNG
(1-(2,3-dihydro-1H-inden-2- yl)-6-(3,4,5- trimethox...)
Show SMILES COc1cc(cc(OC)c1OC)-c1cnc2[nH]c(=O)n(C3Cc4ccccc4C3)c2n1
Show InChI InChI=1S/C23H22N4O4/c1-29-18-10-15(11-19(30-2)20(18)31-3)17-12-24-21-22(25-17)27(23(28)26-21)16-8-13-6-4-5-7-14(13)9-16/h4-7,10-12,16H,8-9H2,1-3H3,(H,24,26,28)
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n/an/a<100n/an/an/an/an/an/a



The University of Rochester; Board of Regents of the University of Nebraska

US Patent


Assay Description
200 ng (130 nM) MLK3 (Dundee, DU8313) was incubated with 1 μM inactive MKK7b (Dundee, DU703) in the presence of 2 μM cold ATP (Km) and 0.5 ...


US Patent US10485800 (2019)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 11


(Homo sapiens (Human))
BDBM354864
PNG
(Preparation of 4-{4-[3-(1H-indol-5-yl)-1H-pyrrolo[...)
Show SMILES CN1CCN(Cc2ccc(cc2)-c2cnc3[nH]cc(-c4ccc5[nH]ccc5c4)c3c2)CC1=O
Show InChI InChI=1S/C27H25N5O/c1-31-10-11-32(17-26(31)33)16-18-2-4-19(5-3-18)22-13-23-24(15-30-27(23)29-14-22)20-6-7-25-21(12-20)8-9-28-25/h2-9,12-15,28H,10-11,16-17H2,1H3,(H,29,30)
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n/an/a<100n/an/an/an/an/an/a



The University of Rochester; Board of Regents of the University of Nebraska

US Patent


Assay Description
200 ng (130 nM) MLK3 (Dundee, DU8313) was incubated with 1 μM inactive MKK7b (Dundee, DU703) in the presence of 2 μM cold ATP (Km) and 0.5 ...


US Patent US10485800 (2019)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 11


(Homo sapiens (Human))
BDBM354871
PNG
(US10485800, Example 148 | US9814704, Example 148)
Show SMILES CC(C)(C)OC(=O)N1CCN(CC1)C(=O)c1ccc(cc1)-c1cnc2[nH]cc(-c3ccc(cc3)C(N)=O)c2c1
Show InChI InChI=1S/C30H31N5O4/c1-30(2,3)39-29(38)35-14-12-34(13-15-35)28(37)22-10-4-19(5-11-22)23-16-24-25(18-33-27(24)32-17-23)20-6-8-21(9-7-20)26(31)36/h4-11,16-18H,12-15H2,1-3H3,(H2,31,36)(H,32,33)
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n/an/a<100n/an/an/an/an/an/a



The University of Rochester; Board of Regents of the University of Nebraska

US Patent


Assay Description
200 ng (130 nM) MLK3 (Dundee, DU8313) was incubated with 1 μM inactive MKK7b (Dundee, DU703) in the presence of 2 μM cold ATP (Km) and 0.5 ...


US Patent US10485800 (2019)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 11


(Homo sapiens (Human))
BDBM420212
PNG
(US10485800, Cmpd ID Preparation of 4-(4-(3-(1H-ind...)
Show SMILES C(N1CCOCC1)c1ccc(cc1)-c1cnc2[nH]cc(-c3ccc4[nH]ccc4c3)c2c1
Show InChI InChI=1S/C26H22N4O/c1-3-19(4-2-18(1)17-30-9-11-31-12-10-30)22-14-23-24(16-29-26(23)28-15-22)20-5-6-25-21(13-20)7-8-27-25/h1-8,13-16H,9-12,17H2/b24-20+
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n/an/a<100n/an/an/an/an/an/a



The University of Rochester; Board of Regents of the University of Nebraska

US Patent


Assay Description
200 ng (130 nM) MLK3 (Dundee, DU8313) was incubated with 1 μM inactive MKK7b (Dundee, DU703) in the presence of 2 μM cold ATP (Km) and 0.5 ...


US Patent US10485800 (2019)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 11


(Homo sapiens (Human))
BDBM420225
PNG
(US10485800, Cmpd ID GO | US10485800, Example 192)
Show SMILES CC(C)(C)CC(=O)N1CCN(Cc2ccc(cc2)-c2cnc3[nH]cc(-c4ccc5[nH]ccc5c4)c3c2)CC1
Show InChI InChI=1S/C32H33N5O/c1-32(2,3)18-30(38)37-14-12-36(13-15-37)21-22-4-6-23(7-5-22)26-17-27-28(20-35-31(27)34-19-26)24-8-9-29-25(16-24)10-11-33-29/h4-11,16-17,19-20H,12-15,18,21H2,1-3H3/b28-24+
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n/an/a<100n/an/an/an/an/an/a



The University of Rochester; Board of Regents of the University of Nebraska

US Patent


Assay Description
200 ng (130 nM) MLK3 (Dundee, DU8313) was incubated with 1 μM inactive MKK7b (Dundee, DU703) in the presence of 2 μM cold ATP (Km) and 0.5 ...


US Patent US10485800 (2019)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 11


(Homo sapiens (Human))
BDBM420234
PNG
(US10485800, Cmpd ID GX | US10485800, Example 201)
Show SMILES OCCC(=O)N1CCN(Cc2ccc(cc2)-c2cnc3[nH]cc(-c4ccc5[nH]ccc5c4)c3c2)CC1
Show InChI InChI=1S/C29H27N5O2/c35-14-8-28(36)34-12-10-33(11-13-34)19-20-1-3-21(4-2-20)24-16-25-26(18-32-29(25)31-17-24)22-5-6-27-23(15-22)7-9-30-27/h1-7,9,15-18,35H,8,10-14,19H2/b26-22+
PDB

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n/an/a<100n/an/an/an/an/an/a



The University of Rochester; Board of Regents of the University of Nebraska

US Patent


Assay Description
200 ng (130 nM) MLK3 (Dundee, DU8313) was incubated with 1 μM inactive MKK7b (Dundee, DU703) in the presence of 2 μM cold ATP (Km) and 0.5 ...


US Patent US10485800 (2019)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 11


(Homo sapiens (Human))
BDBM420241
PNG
(US10485800, Cmpd ID 5-(4-((3,4-dimethylpiperazin-1...)
Show SMILES CC1CN(Cc2ccc(cc2)-c2cnc3[nH]cc(-c4ccc5[nH]ccc5c4)c3c2)CCN1C
Show InChI InChI=1S/C28H27N5/c1-19-17-33(12-11-32(19)2)18-20-3-5-21(6-4-20)24-14-25-26(16-31-28(25)30-15-24)22-7-8-27-23(13-22)9-10-29-27/h3-10,13-16,19H,11-12,17-18H2,1-2H3/b26-22+
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n/an/a<100n/an/an/an/an/an/a



The University of Rochester; Board of Regents of the University of Nebraska

US Patent


Assay Description
200 ng (130 nM) MLK3 (Dundee, DU8313) was incubated with 1 μM inactive MKK7b (Dundee, DU703) in the presence of 2 μM cold ATP (Km) and 0.5 ...


US Patent US10485800 (2019)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 11


(Homo sapiens (Human))
BDBM354753
PNG
(US10485800, Example 30 | US9814704, Example 30)
Show SMILES Cc1ccc(cc1)S(=O)(=O)n1cc(-c2ccc3[nH]ccc3c2)c2cc(cnc12)-c1ccc(F)nc1
Show InChI InChI=1S/C27H19FN4O2S/c1-17-2-6-22(7-3-17)35(33,34)32-16-24(18-4-8-25-19(12-18)10-11-29-25)23-13-21(15-31-27(23)32)20-5-9-26(28)30-14-20/h2-16,29H,1H3
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n/an/a<100n/an/an/an/an/an/a



The University of Rochester; Board of Regents of the University of Nebraska

US Patent


Assay Description
200 ng (130 nM) MLK3 (Dundee, DU8313) was incubated with 1 μM inactive MKK7b (Dundee, DU703) in the presence of 2 μM cold ATP (Km) and 0.5 ...


US Patent US10485800 (2019)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 11


(Homo sapiens (Human))
BDBM354760
PNG
(Preparation of 2-(3,4-dimethoxyphenyl)-7-(1H-indol...)
Show SMILES COc1ccc(cc1OC)-c1cnc2[nH]cc(-c3ccc4[nH]ccc4c3)c2n1
Show InChI InChI=1S/C22H18N4O2/c1-27-19-6-4-14(10-20(19)28-2)18-12-25-22-21(26-18)16(11-24-22)13-3-5-17-15(9-13)7-8-23-17/h3-12,23H,1-2H3,(H,24,25)
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n/an/a<100n/an/an/an/an/an/a



The University of Rochester; Board of Regents of the University of Nebraska

US Patent


Assay Description
200 ng (130 nM) MLK3 (Dundee, DU8313) was incubated with 1 μM inactive MKK7b (Dundee, DU703) in the presence of 2 μM cold ATP (Km) and 0.5 ...


US Patent US10485800 (2019)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 11


(Homo sapiens (Human))
BDBM354761
PNG
(Preparation of 4-(7-(1H-indol-5-yl)-5H-pyrrolo[3,2...)
Show SMILES COc1cc(ccc1N)-c1cnc2[nH]cc(-c3ccc4[nH]ccc4c3)c2n1
Show InChI InChI=1S/C21H17N5O/c1-27-19-9-13(2-4-16(19)22)18-11-25-21-20(26-18)15(10-24-21)12-3-5-17-14(8-12)6-7-23-17/h2-11,23H,22H2,1H3,(H,24,25)
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n/an/a<100n/an/an/an/an/an/a



The University of Rochester; Board of Regents of the University of Nebraska

US Patent


Assay Description
200 ng (130 nM) MLK3 (Dundee, DU8313) was incubated with 1 μM inactive MKK7b (Dundee, DU703) in the presence of 2 μM cold ATP (Km) and 0.5 ...


US Patent US10485800 (2019)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 11


(Homo sapiens (Human))
BDBM354835
PNG
(1-(1H-pyrrolo[2,3- b]pyridin-5-yl)-6-(3,4,5- trime...)
Show SMILES COc1cc(cc(OC)c1OC)-c1cnc2[nH]c(=O)n(-c3cnc4[nH]ccc4c3)c2n1
Show InChI InChI=1S/C21H18N6O4/c1-29-15-7-12(8-16(30-2)17(15)31-3)14-10-24-19-20(25-14)27(21(28)26-19)13-6-11-4-5-22-18(11)23-9-13/h4-10H,1-3H3,(H,22,23)(H,24,26,28)
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n/an/a<100n/an/an/an/an/an/a



The University of Rochester; Board of Regents of the University of Nebraska

US Patent


Assay Description
200 ng (130 nM) MLK3 (Dundee, DU8313) was incubated with 1 μM inactive MKK7b (Dundee, DU703) in the presence of 2 μM cold ATP (Km) and 0.5 ...


US Patent US10485800 (2019)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 11


(Homo sapiens (Human))
BDBM354866
PNG
(Preparation of 4-{3-[3-(1H-indol-5-yl)-1H-pyrrolo[...)
Show SMILES CN1CCN(Cc2cccc(c2)-c2cnc3[nH]cc(-c4ccc5[nH]ccc5c4)c3c2)CC1=O
Show InChI InChI=1S/C27H25N5O/c1-31-9-10-32(17-26(31)33)16-18-3-2-4-19(11-18)22-13-23-24(15-30-27(23)29-14-22)20-5-6-25-21(12-20)7-8-28-25/h2-8,11-15,28H,9-10,16-17H2,1H3,(H,29,30)
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n/an/a<100n/an/an/an/an/an/a



The University of Rochester; Board of Regents of the University of Nebraska

US Patent


Assay Description
200 ng (130 nM) MLK3 (Dundee, DU8313) was incubated with 1 μM inactive MKK7b (Dundee, DU703) in the presence of 2 μM cold ATP (Km) and 0.5 ...


US Patent US10485800 (2019)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 11


(Homo sapiens (Human))
BDBM420227
PNG
(US10485800, Cmpd ID GQ | US10485800, Example 194)
Show SMILES COC(=O)N1CCN(Cc2ccc(cc2)-c2cnc3[nH]cc(-c4ccc5[nH]ccc5c4)c3c2)CC1
Show InChI InChI=1S/C28H25N5O2/c1-35-28(34)33-12-10-32(11-13-33)18-19-2-4-20(5-3-19)23-15-24-25(17-31-27(24)30-16-23)21-6-7-26-22(14-21)8-9-29-26/h2-9,14-17H,10-13,18H2,1H3/b25-21+
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The University of Rochester; Board of Regents of the University of Nebraska

US Patent


Assay Description
200 ng (130 nM) MLK3 (Dundee, DU8313) was incubated with 1 μM inactive MKK7b (Dundee, DU703) in the presence of 2 μM cold ATP (Km) and 0.5 ...


US Patent US10485800 (2019)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 11


(Homo sapiens (Human))
BDBM50441566
PNG
(CHEMBL2436977 | US10485800, Example 179)
Show SMILES CN1CCN(Cc2ccc(cc2)-c2cnc3[nH]cc(-c4cnc5[nH]ccc5c4)c3c2)CC1
Show InChI InChI=1S/C26H26N6/c1-31-8-10-32(11-9-31)17-18-2-4-19(5-3-18)21-13-23-24(16-30-26(23)29-14-21)22-12-20-6-7-27-25(20)28-15-22/h2-7,12-16H,8-11,17H2,1H3,(H,27,28)(H,29,30)
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n/an/a<100n/an/an/an/an/an/a



The University of Rochester; Board of Regents of the University of Nebraska

US Patent


Assay Description
200 ng (130 nM) MLK3 (Dundee, DU8313) was incubated with 1 μM inactive MKK7b (Dundee, DU703) in the presence of 2 μM cold ATP (Km) and 0.5 ...


US Patent US10485800 (2019)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 11


(Homo sapiens (Human))
BDBM420245
PNG
(US10485800, Cmpd ID FZ | US10485800, Example 180)
Show SMILES CN1CCN(Cc2ccc(cc2)-c2cnc3[nH]cc(-c4ccc5ncccc5c4)c3c2)CC1
Show InChI InChI=1S/C28H27N5/c1-32-11-13-33(14-12-32)19-20-4-6-21(7-5-20)24-16-25-26(18-31-28(25)30-17-24)22-8-9-27-23(15-22)3-2-10-29-27/h2-10,15-18H,11-14,19H2,1H3,(H,30,31)
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The University of Rochester; Board of Regents of the University of Nebraska

US Patent


Assay Description
200 ng (130 nM) MLK3 (Dundee, DU8313) was incubated with 1 μM inactive MKK7b (Dundee, DU703) in the presence of 2 μM cold ATP (Km) and 0.5 ...


US Patent US10485800 (2019)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 11


(Homo sapiens (Human))
BDBM354731
PNG
(Preparation of 4-(3-(1H-indol-5-yl)-1H-pyrrolo[2,3...)
Show SMILES Nc1ccc(cc1)-c1cnc2[nH]cc(-c3ccc4[nH]ccc4c3)c2c1
Show InChI InChI=1S/C21H16N4/c22-17-4-1-13(2-5-17)16-10-18-19(12-25-21(18)24-11-16)14-3-6-20-15(9-14)7-8-23-20/h1-12,23H,22H2,(H,24,25)
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The University of Rochester; Board of Regents of the University of Nebraska

US Patent


Assay Description
200 ng (130 nM) MLK3 (Dundee, DU8313) was incubated with 1 μM inactive MKK7b (Dundee, DU703) in the presence of 2 μM cold ATP (Km) and 0.5 ...


US Patent US10485800 (2019)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 11


(Homo sapiens (Human))
BDBM50441568
PNG
(CHEMBL2436983 | US10485800, Example 9 | US9814704,...)
Show SMILES Nc1ncc(cn1)-c1cnc2[nH]cc(-c3ccc4[nH]ccc4c3)c2c1
Show InChI InChI=1S/C19H14N6/c20-19-24-8-14(9-25-19)13-6-15-16(10-23-18(15)22-7-13)11-1-2-17-12(5-11)3-4-21-17/h1-10,21H,(H,22,23)(H2,20,24,25)
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The University of Rochester; Board of Regents of the University of Nebraska

US Patent


Assay Description
200 ng (130 nM) MLK3 (Dundee, DU8313) was incubated with 1 μM inactive MKK7b (Dundee, DU703) in the presence of 2 μM cold ATP (Km) and 0.5 ...


US Patent US10485800 (2019)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 11


(Homo sapiens (Human))
BDBM354748
PNG
(Preparation of 4-(5-(3,4,5-trimethoxyphenyl)-1H-py...)
Show SMILES COc1cc(cc(OC)c1OC)-c1cnc2[nH]cc(-c3ccc(cc3)C(N)=O)c2c1
Show InChI InChI=1S/C23H21N3O4/c1-28-19-9-15(10-20(29-2)21(19)30-3)16-8-17-18(12-26-23(17)25-11-16)13-4-6-14(7-5-13)22(24)27/h4-12H,1-3H3,(H2,24,27)(H,25,26)
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n/an/a<100n/an/an/an/an/an/a



The University of Rochester; Board of Regents of the University of Nebraska

US Patent


Assay Description
200 ng (130 nM) MLK3 (Dundee, DU8313) was incubated with 1 μM inactive MKK7b (Dundee, DU703) in the presence of 2 μM cold ATP (Km) and 0.5 ...


US Patent US10485800 (2019)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 11


(Homo sapiens (Human))
BDBM354756
PNG
(Preparation of 1-(4-(3-(1H-indol-5-yl)-1H-pyrrolo[...)
Show SMILES CN(C)Cc1ccc(cc1)-c1cnc2[nH]cc(-c3ccc4[nH]ccc4c3)c2c1
Show InChI InChI=1S/C24H22N4/c1-28(2)15-16-3-5-17(6-4-16)20-12-21-22(14-27-24(21)26-13-20)18-7-8-23-19(11-18)9-10-25-23/h3-14,25H,15H2,1-2H3,(H,26,27)
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n/an/a<100n/an/an/an/an/an/a



The University of Rochester; Board of Regents of the University of Nebraska

US Patent


Assay Description
200 ng (130 nM) MLK3 (Dundee, DU8313) was incubated with 1 μM inactive MKK7b (Dundee, DU703) in the presence of 2 μM cold ATP (Km) and 0.5 ...


US Patent US10485800 (2019)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 11


(Homo sapiens (Human))
BDBM420060
PNG
(US10485800, Cmpd ID AJ | US10485800, Example 34)
Show SMILES COc1cc(ccc1OCCN1CCNCC1)-c1cnc2[nH]cc(-c3ccc4[nH]ccc4c3)c2c1
Show InChI InChI=1S/C28H27N5O2/c1-34-27-16-19(3-5-26(27)35-13-12-33-10-8-29-9-11-33)22-15-23-24(18-32-28(23)31-17-22)20-2-4-25-21(14-20)6-7-30-25/h2-7,14-18,29H,8-13H2,1H3/b24-20+
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The University of Rochester; Board of Regents of the University of Nebraska

US Patent


Assay Description
200 ng (130 nM) MLK3 (Dundee, DU8313) was incubated with 1 μM inactive MKK7b (Dundee, DU703) in the presence of 2 μM cold ATP (Km) and 0.5 ...


US Patent US10485800 (2019)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 11


(Homo sapiens (Human))
BDBM354778
PNG
(6-(4-hydroxy-3- methoxyphenyl)-1-(1H- indol-5-yl)-...)
Show SMILES COc1cc(ccc1O)-c1cnc2[nH]c(=O)n(-c3ccc4[nH]ccc4c3)c2n1
Show InChI InChI=1S/C20H15N5O3/c1-28-17-9-11(2-5-16(17)26)15-10-22-18-19(23-15)25(20(27)24-18)13-3-4-14-12(8-13)6-7-21-14/h2-10,21,26H,1H3,(H,22,24,27)
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n/an/a<100n/an/an/an/an/an/a



The University of Rochester; Board of Regents of the University of Nebraska

US Patent


Assay Description
200 ng (130 nM) MLK3 (Dundee, DU8313) was incubated with 1 μM inactive MKK7b (Dundee, DU703) in the presence of 2 μM cold ATP (Km) and 0.5 ...


US Patent US10485800 (2019)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 11


(Homo sapiens (Human))
BDBM354881
PNG
(Preparation of 4-{5-[4-(4-methyl-3-oxo-piperazin-1...)
Show SMILES CN1CCN(Cc2ccc(cc2)-c2cnc3[nH]cc(-c4ccc(cc4)C(N)=O)c3c2)CC1=O
Show InChI InChI=1S/C26H25N5O2/c1-30-10-11-31(16-24(30)32)15-17-2-4-18(5-3-17)21-12-22-23(14-29-26(22)28-13-21)19-6-8-20(9-7-19)25(27)33/h2-9,12-14H,10-11,15-16H2,1H3,(H2,27,33)(H,28,29)
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n/an/a<100n/an/an/an/an/an/a



The University of Rochester; Board of Regents of the University of Nebraska

US Patent


Assay Description
200 ng (130 nM) MLK3 (Dundee, DU8313) was incubated with 1 μM inactive MKK7b (Dundee, DU703) in the presence of 2 μM cold ATP (Km) and 0.5 ...


US Patent US10485800 (2019)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 11


(Homo sapiens (Human))
BDBM420237
PNG
(US10485800, Cmpd ID HA | US10485800, Example 204)
Show SMILES CC(C)CC(=O)N1CCN(Cc2ccc(cc2)-c2cnc3[nH]cc(-c4ccc5[nH]ccc5c4)c3c2)CC1
Show InChI InChI=1S/C31H31N5O/c1-21(2)15-30(37)36-13-11-35(12-14-36)20-22-3-5-23(6-4-22)26-17-27-28(19-34-31(27)33-18-26)24-7-8-29-25(16-24)9-10-32-29/h3-10,16-19,21H,11-15,20H2,1-2H3/b28-24+
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The University of Rochester; Board of Regents of the University of Nebraska

US Patent


Assay Description
200 ng (130 nM) MLK3 (Dundee, DU8313) was incubated with 1 μM inactive MKK7b (Dundee, DU703) in the presence of 2 μM cold ATP (Km) and 0.5 ...


US Patent US10485800 (2019)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 11


(Homo sapiens (Human))
BDBM354728
PNG
(Preparation of 4-(3-(1H-indol-5-yl)-1H-pyrrolo[2,3...)
Show SMILES COc1cc(ccc1N)-c1cnc2[nH]cc(-c3ccc4[nH]ccc4c3)c2c1
Show InChI InChI=1S/C22H18N4O/c1-27-21-10-13(2-4-19(21)23)16-9-17-18(12-26-22(17)25-11-16)14-3-5-20-15(8-14)6-7-24-20/h2-12,24H,23H2,1H3,(H,25,26)
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n/an/a<100n/an/an/an/an/an/a



The University of Rochester; Board of Regents of the University of Nebraska

US Patent


Assay Description
200 ng (130 nM) MLK3 (Dundee, DU8313) was incubated with 1 μM inactive MKK7b (Dundee, DU703) in the presence of 2 μM cold ATP (Km) and 0.5 ...


US Patent US10485800 (2019)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 11


(Homo sapiens (Human))
BDBM354734
PNG
(Preparation of N-(4-(3-(1H-indol-5-yl)-1H-pyrrolo[...)
Show SMILES CS(=O)(=O)Nc1ccc(cc1)-c1cnc2[nH]cc(-c3ccc4[nH]ccc4c3)c2c1
Show InChI InChI=1S/C22H18N4O2S/c1-29(27,28)26-18-5-2-14(3-6-18)17-11-19-20(13-25-22(19)24-12-17)15-4-7-21-16(10-15)8-9-23-21/h2-13,23,26H,1H3,(H,24,25)
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n/an/a<100n/an/an/an/an/an/a



The University of Rochester; Board of Regents of the University of Nebraska

US Patent


Assay Description
200 ng (130 nM) MLK3 (Dundee, DU8313) was incubated with 1 μM inactive MKK7b (Dundee, DU703) in the presence of 2 μM cold ATP (Km) and 0.5 ...


US Patent US10485800 (2019)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 11


(Homo sapiens (Human))
BDBM50441570
PNG
(CHEMBL2436976 | US10485800, Example 17 | US9814704...)
Show SMILES COc1cc(cc(OC)c1OC)-c1cnc2[nH]cc(-c3cnc(N)nc3)c2c1
Show InChI InChI=1S/C20H19N5O3/c1-26-16-5-11(6-17(27-2)18(16)28-3)12-4-14-15(10-23-19(14)22-7-12)13-8-24-20(21)25-9-13/h4-10H,1-3H3,(H,22,23)(H2,21,24,25)
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n/an/a<100n/an/an/an/an/an/a



The University of Rochester; Board of Regents of the University of Nebraska

US Patent


Assay Description
200 ng (130 nM) MLK3 (Dundee, DU8313) was incubated with 1 μM inactive MKK7b (Dundee, DU703) in the presence of 2 μM cold ATP (Km) and 0.5 ...


US Patent US10485800 (2019)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 11


(Homo sapiens (Human))
BDBM354749
PNG
(Preparation of 4-(5-(3,4-dimethoxyphenyl)-1H-pyrro...)
Show SMILES COc1ccc(cc1OC)-c1cnc2[nH]cc(-c3ccc(cc3)C(N)=O)c2c1
Show InChI InChI=1S/C22H19N3O3/c1-27-19-8-7-15(10-20(19)28-2)16-9-17-18(12-25-22(17)24-11-16)13-3-5-14(6-4-13)21(23)26/h3-12H,1-2H3,(H2,23,26)(H,24,25)
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n/an/a<100n/an/an/an/an/an/a



The University of Rochester; Board of Regents of the University of Nebraska

US Patent


Assay Description
200 ng (130 nM) MLK3 (Dundee, DU8313) was incubated with 1 μM inactive MKK7b (Dundee, DU703) in the presence of 2 μM cold ATP (Km) and 0.5 ...


US Patent US10485800 (2019)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 11


(Homo sapiens (Human))
BDBM354785
PNG
(6-(4-hydroxy-3,5- dimethoxyphenyl)-1-(1H- indol-5-...)
Show SMILES COc1cc(cc(OC)c1O)-c1cnc2[nH]c(=O)n(-c3ccc4[nH]ccc4c3)c2n1
Show InChI InChI=1S/C21H17N5O4/c1-29-16-8-12(9-17(30-2)18(16)27)15-10-23-19-20(24-15)26(21(28)25-19)13-3-4-14-11(7-13)5-6-22-14/h3-10,22,27H,1-2H3,(H,23,25,28)
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n/an/a<100n/an/an/an/an/an/a



The University of Rochester; Board of Regents of the University of Nebraska

US Patent


Assay Description
200 ng (130 nM) MLK3 (Dundee, DU8313) was incubated with 1 μM inactive MKK7b (Dundee, DU703) in the presence of 2 μM cold ATP (Km) and 0.5 ...


US Patent US10485800 (2019)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 11


(Homo sapiens (Human))
BDBM354869
PNG
(Preparation of 1-(4-{4-[3-(1H-indol-5-yl)-1H-pyrro...)
Show SMILES CC(=O)N1CCN(CC1)C(=O)c1ccc(cc1)-c1cnc2[nH]cc(-c3ccc4[nH]ccc4c3)c2c1
Show InChI InChI=1S/C28H25N5O2/c1-18(34)32-10-12-33(13-11-32)28(35)20-4-2-19(3-5-20)23-15-24-25(17-31-27(24)30-16-23)21-6-7-26-22(14-21)8-9-29-26/h2-9,14-17,29H,10-13H2,1H3,(H,30,31)
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n/an/a<100n/an/an/an/an/an/a



The University of Rochester; Board of Regents of the University of Nebraska

US Patent


Assay Description
200 ng (130 nM) MLK3 (Dundee, DU8313) was incubated with 1 μM inactive MKK7b (Dundee, DU703) in the presence of 2 μM cold ATP (Km) and 0.5 ...


US Patent US10485800 (2019)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 11


(Homo sapiens (Human))
BDBM420229
PNG
(US10485800, Cmpd ID GS | US10485800, Example 196)
Show SMILES CC(C)C(=O)N1CCN(Cc2ccc(cc2)-c2cnc3[nH]cc(-c4ccc5[nH]ccc5c4)c3c2)CC1
Show InChI InChI=1S/C30H29N5O/c1-20(2)30(36)35-13-11-34(12-14-35)19-21-3-5-22(6-4-21)25-16-26-27(18-33-29(26)32-17-25)23-7-8-28-24(15-23)9-10-31-28/h3-10,15-18,20H,11-14,19H2,1-2H3/b27-23+
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n/an/a<100n/an/an/an/an/an/a



The University of Rochester; Board of Regents of the University of Nebraska

US Patent


Assay Description
200 ng (130 nM) MLK3 (Dundee, DU8313) was incubated with 1 μM inactive MKK7b (Dundee, DU703) in the presence of 2 μM cold ATP (Km) and 0.5 ...


US Patent US10485800 (2019)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 11


(Homo sapiens (Human))
BDBM420242
PNG
(US10485800, Cmpd ID Preparation of 5-(4-((1H-imida...)
Show SMILES C(c1ccc(cc1)-c1cnc2[nH]cc(-c3ccc4[nH]ccc4c3)c2c1)n1ccnc1
Show InChI InChI=1S/C25H17N5/c1-3-18(4-2-17(1)15-30-10-9-26-16-30)21-12-22-23(14-29-25(22)28-13-21)19-5-6-24-20(11-19)7-8-27-24/h1-14,16H,15H2/b23-19+
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n/an/a<100n/an/an/an/an/an/a



The University of Rochester; Board of Regents of the University of Nebraska

US Patent


Assay Description
200 ng (130 nM) MLK3 (Dundee, DU8313) was incubated with 1 μM inactive MKK7b (Dundee, DU703) in the presence of 2 μM cold ATP (Km) and 0.5 ...


US Patent US10485800 (2019)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 11


(Homo sapiens (Human))
BDBM354742
PNG
(Preparation of N,N-dimethyl-5-(5-(3,4,5-trimethoxy...)
Show SMILES COc1cc(cc(OC)c1OC)-c1cnc2[nH]cc(-c3ccc(nc3)N(C)C)c2c1
Show InChI InChI=1S/C23H24N4O3/c1-27(2)21-7-6-14(11-24-21)18-13-26-23-17(18)8-16(12-25-23)15-9-19(28-3)22(30-5)20(10-15)29-4/h6-13H,1-5H3,(H,25,26)
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n/an/a<100n/an/an/an/an/an/a



The University of Rochester; Board of Regents of the University of Nebraska

US Patent


Assay Description
200 ng (130 nM) MLK3 (Dundee, DU8313) was incubated with 1 μM inactive MKK7b (Dundee, DU703) in the presence of 2 μM cold ATP (Km) and 0.5 ...


US Patent US10485800 (2019)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 11


(Homo sapiens (Human))
BDBM420062
PNG
(US10485800, Cmpd ID AL | US10485800, Example 36)
Show SMILES Cc1ccc(cc1)S(=O)(=O)n1cc(I)c2nc(Br)cnc12
Show InChI InChI=1S/C13H9BrIN3O2S/c1-8-2-4-9(5-3-8)21(19,20)18-7-10(15)12-13(18)16-6-11(14)17-12/h2-7H,1H3
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n/an/a<100n/an/an/an/an/an/a



The University of Rochester; Board of Regents of the University of Nebraska

US Patent


Assay Description
200 ng (130 nM) MLK3 (Dundee, DU8313) was incubated with 1 μM inactive MKK7b (Dundee, DU703) in the presence of 2 μM cold ATP (Km) and 0.5 ...


US Patent US10485800 (2019)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 11


(Homo sapiens (Human))
BDBM50441573
PNG
(CHEMBL2436979 | US10485800, Example 40 | US9814704...)
Show SMILES COc1cc(cc(OC)c1OC)-c1cnc2[nH]c(=O)n(-c3ccc4[nH]ccc4c3)c2n1
Show InChI InChI=1S/C22H19N5O4/c1-29-17-9-13(10-18(30-2)19(17)31-3)16-11-24-20-21(25-16)27(22(28)26-20)14-4-5-15-12(8-14)6-7-23-15/h4-11,23H,1-3H3,(H,24,26,28)
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n/an/a<100n/an/an/an/an/an/a



The University of Rochester; Board of Regents of the University of Nebraska

US Patent


Assay Description
200 ng (130 nM) MLK3 (Dundee, DU8313) was incubated with 1 μM inactive MKK7b (Dundee, DU703) in the presence of 2 μM cold ATP (Km) and 0.5 ...


US Patent US10485800 (2019)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 11


(Homo sapiens (Human))
BDBM354783
PNG
(6-(4-amino-3- methoxyphenyl)-1-(1H- indol-5-yl)-1H...)
Show SMILES COc1cc(ccc1N)-c1cnc2[nH]c(=O)n(-c3ccc4[nH]ccc4c3)c2n1
Show InChI InChI=1S/C20H16N6O2/c1-28-17-9-11(2-4-14(17)21)16-10-23-18-19(24-16)26(20(27)25-18)13-3-5-15-12(8-13)6-7-22-15/h2-10,22H,21H2,1H3,(H,23,25,27)
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n/an/a<100n/an/an/an/an/an/a



The University of Rochester; Board of Regents of the University of Nebraska

US Patent


Assay Description
200 ng (130 nM) MLK3 (Dundee, DU8313) was incubated with 1 μM inactive MKK7b (Dundee, DU703) in the presence of 2 μM cold ATP (Km) and 0.5 ...


US Patent US10485800 (2019)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 11


(Homo sapiens (Human))
BDBM354825
PNG
(1-(1H-benzo[d]imidazol-5- yl)-6-(3,4,5- trimethoxy...)
Show SMILES COc1cc(cc(OC)c1OC)-c1cnc2[nH]c(=O)n(-c3ccc4[nH]cnc4c3)c2n1
Show InChI InChI=1S/C21H18N6O4/c1-29-16-6-11(7-17(30-2)18(16)31-3)15-9-22-19-20(25-15)27(21(28)26-19)12-4-5-13-14(8-12)24-10-23-13/h4-10H,1-3H3,(H,23,24)(H,22,26,28)
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n/an/a<100n/an/an/an/an/an/a



The University of Rochester; Board of Regents of the University of Nebraska

US Patent


Assay Description
200 ng (130 nM) MLK3 (Dundee, DU8313) was incubated with 1 μM inactive MKK7b (Dundee, DU703) in the presence of 2 μM cold ATP (Km) and 0.5 ...


US Patent US10485800 (2019)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 11


(Homo sapiens (Human))
BDBM354865
PNG
(Preparation of 4-{4-[3-(1H-indol-5-yl)-1H-pyrrolo[...)
Show SMILES O=C1CN(Cc2ccc(cc2)-c2cnc3[nH]cc(-c4ccc5[nH]ccc5c4)c3c2)CCN1
Show InChI InChI=1S/C26H23N5O/c32-25-16-31(10-9-28-25)15-17-1-3-18(4-2-17)21-12-22-23(14-30-26(22)29-13-21)19-5-6-24-20(11-19)7-8-27-24/h1-8,11-14,27H,9-10,15-16H2,(H,28,32)(H,29,30)
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n/an/a<100n/an/an/an/an/an/a



The University of Rochester; Board of Regents of the University of Nebraska

US Patent


Assay Description
200 ng (130 nM) MLK3 (Dundee, DU8313) was incubated with 1 μM inactive MKK7b (Dundee, DU703) in the presence of 2 μM cold ATP (Km) and 0.5 ...


US Patent US10485800 (2019)

More data for this
Ligand-Target Pair
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* indicates data uncertainty>20%