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Patent code US10485803

Compile Data Set for Download or QSAR
Found 106 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
JAK1/TYK2


(Homo sapiens (Human))
BDBM279815
PNG
(5-(((1R,3s,5S)-3-((4-((5-(hydroxymethyl)-1H-pyrazo...)
Show SMILES COc1cc(Nc2cc(CO)[nH]n2)nc(n1)N(C)[C@H]1C[C@@H]2CCC[C@H](C1)N2Cc1cncc(c1)C#N
Show InChI InChI=1/C25H31N9O2/c1-33(25-29-22(10-24(30-25)36-2)28-23-7-18(15-35)31-32-23)21-8-19-4-3-5-20(9-21)34(19)14-17-6-16(11-26)12-27-13-17/h6-7,10,12-13,19-21,35H,3-5,8-9,14-15H2,1-2H3,(H2,28,29,30,31,32)/t19-,20+,21-
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<0.100n/an/an/an/an/an/an/an/a



THERAVANCE BIOPHARMA R&D IP, LLC

US Patent


Assay Description
A panel of four LanthaScreen JAK biochemical assays (JAK1, 2, 3 and Tyk2) were carried in a common kinase reaction buffer (50 mM HEPES, pH 7.5, 0.01%...


US Patent US10485803 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM279831
PNG
(US10028960, Example 1-14 | US10485803, Example 1-1...)
Show SMILES COc1cc(Nc2cc(CO)[nH]n2)nc(n1)N(C)[C@H]1C[C@@H]2CCC[C@H](C1)N2S(=O)(=O)C1CC1
Show InChI InChI=1/C21H31N7O4S/c1-27(16-9-14-4-3-5-15(10-16)28(14)33(30,31)17-6-7-17)21-23-18(11-20(24-21)32-2)22-19-8-13(12-29)25-26-19/h8,11,14-17,29H,3-7,9-10,12H2,1-2H3,(H2,22,23,24,25,26)/t14-,15+,16-
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<0.100n/an/an/an/an/an/an/an/a



THERAVANCE BIOPHARMA R&D IP, LLC

US Patent


Assay Description
A panel of four LanthaScreen JAK biochemical assays (JAK1, 2, 3 and Tyk2) were carried in a common kinase reaction buffer (50 mM HEPES, pH 7.5, 0.01%...


US Patent US10485803 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM279832
PNG
(US10028960, Example 1-15 | US10485803, Example 1-1...)
Show SMILES COc1cc(Nc2cc(CO)[nH]n2)nc(n1)N(C)[C@H]1C[C@@H]2CCC[C@H](C1)N2S(=O)(=O)c1cccnc1
Show InChI InChI=1/C23H30N8O4S/c1-30(23-26-20(12-22(27-23)35-2)25-21-9-15(14-32)28-29-21)18-10-16-5-3-6-17(11-18)31(16)36(33,34)19-7-4-8-24-13-19/h4,7-9,12-13,16-18,32H,3,5-6,10-11,14H2,1-2H3,(H2,25,26,27,28,29)/t16-,17+,18-
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<0.100n/an/an/an/an/an/an/an/a



THERAVANCE BIOPHARMA R&D IP, LLC

US Patent


Assay Description
A panel of four LanthaScreen JAK biochemical assays (JAK1, 2, 3 and Tyk2) were carried in a common kinase reaction buffer (50 mM HEPES, pH 7.5, 0.01%...


US Patent US10485803 (2019)

More data for this
Ligand-Target Pair
JAK1/TYK2


(Homo sapiens (Human))
BDBM279810
PNG
(1-(((1R,3s,5S)-3-((4-((5-(Hydroxymethyl)-1H-pyrazo...)
Show SMILES COc1cc(Nc2cc(CO)[nH]n2)nc(n1)N(C)[C@H]1C[C@@H]2CCC[C@H](C1)N2S(=O)(=O)N1CC(C1)C#N
Show InChI InChI=1/C22H31N9O4S/c1-29(22-25-19(9-21(26-22)35-2)24-20-6-15(13-32)27-28-20)18-7-16-4-3-5-17(8-18)31(16)36(33,34)30-11-14(10-23)12-30/h6,9,14,16-18,32H,3-5,7-8,11-13H2,1-2H3,(H2,24,25,26,27,28)/t16-,17+,18-
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<0.100n/an/an/an/an/an/an/an/a



THERAVANCE BIOPHARMA R&D IP, LLC

US Patent


Assay Description
A panel of four LanthaScreen JAK biochemical assays (JAK1, 2, 3 and Tyk2) were carried in a common kinase reaction buffer (50 mM HEPES, pH 7.5, 0.01%...


US Patent US10485803 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM279812
PNG
((3-((6-methoxy-2-(((1R,3s,5S)-9-((2-methoxyethyl)s...)
Show SMILES COCCS(=O)(=O)N1[C@H]2CCC[C@@H]1C[C@H](C2)N(C)c1nc(Nc2cc(CO)[nH]n2)cc(OC)n1
Show InChI InChI=1/C21H33N7O5S/c1-27(17-10-15-5-4-6-16(11-17)28(15)34(30,31)8-7-32-2)21-23-18(12-20(24-21)33-3)22-19-9-14(13-29)25-26-19/h9,12,15-17,29H,4-8,10-11,13H2,1-3H3,(H2,22,23,24,25,26)/t15-,16+,17-
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<0.100n/an/an/an/an/an/an/an/a



THERAVANCE BIOPHARMA R&D IP, LLC

US Patent


Assay Description
A panel of four LanthaScreen JAK biochemical assays (JAK1, 2, 3 and Tyk2) were carried in a common kinase reaction buffer (50 mM HEPES, pH 7.5, 0.01%...


US Patent US10485803 (2019)

More data for this
Ligand-Target Pair
JAK1/TYK2


(Homo sapiens (Human))
BDBM279825
PNG
(US10028960, Example 1-8 | US10485803, Example 1-8)
Show SMILES COc1cc(Nc2cc(CO)[nH]n2)nc(N[C@H]2C[C@@H]3CCC[C@H](C2)N3S(=O)(=O)c2ccccc2)n1
Show InChI InChI=1/C23H29N7O4S/c1-34-22-13-20(25-21-12-16(14-31)28-29-21)26-23(27-22)24-15-10-17-6-5-7-18(11-15)30(17)35(32,33)19-8-3-2-4-9-19/h2-4,8-9,12-13,15,17-18,31H,5-7,10-11,14H2,1H3,(H3,24,25,26,27,28,29)/t15-,17-,18+
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<0.100n/an/an/an/an/an/an/an/a



THERAVANCE BIOPHARMA R&D IP, LLC

US Patent


Assay Description
A panel of four LanthaScreen JAK biochemical assays (JAK1, 2, 3 and Tyk2) were carried in a common kinase reaction buffer (50 mM HEPES, pH 7.5, 0.01%...


US Patent US10485803 (2019)

More data for this
Ligand-Target Pair
JAK1/TYK2


(Homo sapiens (Human))
BDBM279810
PNG
(1-(((1R,3s,5S)-3-((4-((5-(Hydroxymethyl)-1H-pyrazo...)
Show SMILES COc1cc(Nc2cc(CO)[nH]n2)nc(n1)N(C)[C@H]1C[C@@H]2CCC[C@H](C1)N2S(=O)(=O)N1CC(C1)C#N
Show InChI InChI=1/C22H31N9O4S/c1-29(22-25-19(9-21(26-22)35-2)24-20-6-15(13-32)27-28-20)18-7-16-4-3-5-17(8-18)31(16)36(33,34)30-11-14(10-23)12-30/h6,9,14,16-18,32H,3-5,7-8,11-13H2,1-2H3,(H2,24,25,26,27,28)/t16-,17+,18-
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<0.100n/an/an/an/an/an/an/an/a



THERAVANCE BIOPHARMA R&D IP, LLC

US Patent


Assay Description
A panel of four LanthaScreen JAK biochemical assays (JAK1, 2, 3 and Tyk2) were carried in a common kinase reaction buffer (50 mM HEPES, pH 7.5, 0.01%...


US Patent US10485803 (2019)

More data for this
Ligand-Target Pair
JAK1/TYK2


(Homo sapiens (Human))
BDBM279823
PNG
(US10028960, Example 1-6 | US10485803, Example 1-6)
Show SMILES COc1cc(Nc2cc(CO)[nH]n2)nc(N[C@H]2C[C@@H]3CCC[C@H](C2)N3S(=O)(=O)N2CC(C2)C#N)n1
Show InChI InChI=1/C21H29N9O4S/c1-34-20-8-18(24-19-7-15(12-31)27-28-19)25-21(26-20)23-14-5-16-3-2-4-17(6-14)30(16)35(32,33)29-10-13(9-22)11-29/h7-8,13-14,16-17,31H,2-6,10-12H2,1H3,(H3,23,24,25,26,27,28)/t14-,16-,17+
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<0.100n/an/an/an/an/an/an/an/a



THERAVANCE BIOPHARMA R&D IP, LLC

US Patent


Assay Description
A panel of four LanthaScreen JAK biochemical assays (JAK1, 2, 3 and Tyk2) were carried in a common kinase reaction buffer (50 mM HEPES, pH 7.5, 0.01%...


US Patent US10485803 (2019)

More data for this
Ligand-Target Pair
JAK1/TYK2


(Homo sapiens (Human))
BDBM279830
PNG
(US10028960, Example 1-13 | US10485803, Example 1-1...)
Show SMILES COc1cc(Nc2cc(CO)[nH]n2)nc(n1)N(C)[C@H]1C[C@@H]2CCC[C@H](C1)N2S(=O)(=O)N1CCCC1
Show InChI InChI=1/C22H34N8O4S/c1-28(22-24-19(13-21(25-22)34-2)23-20-10-15(14-31)26-27-20)18-11-16-6-5-7-17(12-18)30(16)35(32,33)29-8-3-4-9-29/h10,13,16-18,31H,3-9,11-12,14H2,1-2H3,(H2,23,24,25,26,27)/t16-,17+,18-
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<0.100n/an/an/an/an/an/an/an/a



THERAVANCE BIOPHARMA R&D IP, LLC

US Patent


Assay Description
A panel of four LanthaScreen JAK biochemical assays (JAK1, 2, 3 and Tyk2) were carried in a common kinase reaction buffer (50 mM HEPES, pH 7.5, 0.01%...


US Patent US10485803 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM279810
PNG
(1-(((1R,3s,5S)-3-((4-((5-(Hydroxymethyl)-1H-pyrazo...)
Show SMILES COc1cc(Nc2cc(CO)[nH]n2)nc(n1)N(C)[C@H]1C[C@@H]2CCC[C@H](C1)N2S(=O)(=O)N1CC(C1)C#N
Show InChI InChI=1/C22H31N9O4S/c1-29(22-25-19(9-21(26-22)35-2)24-20-6-15(13-32)27-28-20)18-7-16-4-3-5-17(8-18)31(16)36(33,34)30-11-14(10-23)12-30/h6,9,14,16-18,32H,3-5,7-8,11-13H2,1-2H3,(H2,24,25,26,27,28)/t16-,17+,18-
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<0.100n/an/an/an/an/an/an/an/a



THERAVANCE BIOPHARMA R&D IP, LLC

US Patent


Assay Description
A panel of four LanthaScreen JAK biochemical assays (JAK1, 2, 3 and Tyk2) were carried in a common kinase reaction buffer (50 mM HEPES, pH 7.5, 0.01%...


US Patent US10485803 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM279811
PNG
((3-((6-methoxy-2-(methyl((1R,3s,5S)-9-(methylsulfo...)
Show SMILES COc1cc(Nc2cc(CO)[nH]n2)nc(n1)N(C)[C@H]1C[C@@H]2CCC[C@H](C1)N2S(C)(=O)=O
Show InChI InChI=1/C19H29N7O4S/c1-25(15-8-13-5-4-6-14(9-15)26(13)31(3,28)29)19-21-16(10-18(22-19)30-2)20-17-7-12(11-27)23-24-17/h7,10,13-15,27H,4-6,8-9,11H2,1-3H3,(H2,20,21,22,23,24)/t13-,14+,15-
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<0.100n/an/an/an/an/an/an/an/a



THERAVANCE BIOPHARMA R&D IP, LLC

US Patent


Assay Description
A panel of four LanthaScreen JAK biochemical assays (JAK1, 2, 3 and Tyk2) were carried in a common kinase reaction buffer (50 mM HEPES, pH 7.5, 0.01%...


US Patent US10485803 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM279834
PNG
(US10028960, Example 1-17 | US10485803, Example 1-1...)
Show SMILES COc1cc(Nc2cc(CO)[nH]n2)nc(n1)N(C)[C@H]1C[C@@H]2CCC[C@H](C1)N2S(=O)(=O)N1CCC1
Show InChI InChI=1/C21H32N8O4S/c1-27(21-23-18(12-20(24-21)33-2)22-19-9-14(13-30)25-26-19)17-10-15-5-3-6-16(11-17)29(15)34(31,32)28-7-4-8-28/h9,12,15-17,30H,3-8,10-11,13H2,1-2H3,(H2,22,23,24,25,26)/t15-,16+,17-
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<0.100n/an/an/an/an/an/an/an/a



THERAVANCE BIOPHARMA R&D IP, LLC

US Patent


Assay Description
A panel of four LanthaScreen JAK biochemical assays (JAK1, 2, 3 and Tyk2) were carried in a common kinase reaction buffer (50 mM HEPES, pH 7.5, 0.01%...


US Patent US10485803 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM279810
PNG
(1-(((1R,3s,5S)-3-((4-((5-(Hydroxymethyl)-1H-pyrazo...)
Show SMILES COc1cc(Nc2cc(CO)[nH]n2)nc(n1)N(C)[C@H]1C[C@@H]2CCC[C@H](C1)N2S(=O)(=O)N1CC(C1)C#N
Show InChI InChI=1/C22H31N9O4S/c1-29(22-25-19(9-21(26-22)35-2)24-20-6-15(13-32)27-28-20)18-7-16-4-3-5-17(8-18)31(16)36(33,34)30-11-14(10-23)12-30/h6,9,14,16-18,32H,3-5,7-8,11-13H2,1-2H3,(H2,24,25,26,27,28)/t16-,17+,18-
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<0.100n/an/an/an/an/an/an/an/a



THERAVANCE BIOPHARMA R&D IP, LLC

US Patent


Assay Description
A panel of four LanthaScreen JAK biochemical assays (JAK1, 2, 3 and Tyk2) were carried in a common kinase reaction buffer (50 mM HEPES, pH 7.5, 0.01%...


US Patent US10485803 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM279815
PNG
(5-(((1R,3s,5S)-3-((4-((5-(hydroxymethyl)-1H-pyrazo...)
Show SMILES COc1cc(Nc2cc(CO)[nH]n2)nc(n1)N(C)[C@H]1C[C@@H]2CCC[C@H](C1)N2Cc1cncc(c1)C#N
Show InChI InChI=1/C25H31N9O2/c1-33(25-29-22(10-24(30-25)36-2)28-23-7-18(15-35)31-32-23)21-8-19-4-3-5-20(9-21)34(19)14-17-6-16(11-26)12-27-13-17/h6-7,10,12-13,19-21,35H,3-5,8-9,14-15H2,1-2H3,(H2,28,29,30,31,32)/t19-,20+,21-
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<0.100n/an/an/an/an/an/an/an/a



THERAVANCE BIOPHARMA R&D IP, LLC

US Patent


Assay Description
A panel of four LanthaScreen JAK biochemical assays (JAK1, 2, 3 and Tyk2) were carried in a common kinase reaction buffer (50 mM HEPES, pH 7.5, 0.01%...


US Patent US10485803 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM279830
PNG
(US10028960, Example 1-13 | US10485803, Example 1-1...)
Show SMILES COc1cc(Nc2cc(CO)[nH]n2)nc(n1)N(C)[C@H]1C[C@@H]2CCC[C@H](C1)N2S(=O)(=O)N1CCCC1
Show InChI InChI=1/C22H34N8O4S/c1-28(22-24-19(13-21(25-22)34-2)23-20-10-15(14-31)26-27-20)18-11-16-6-5-7-17(12-18)30(16)35(32,33)29-8-3-4-9-29/h10,13,16-18,31H,3-9,11-12,14H2,1-2H3,(H2,23,24,25,26,27)/t16-,17+,18-
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<0.100n/an/an/an/an/an/an/an/a



THERAVANCE BIOPHARMA R&D IP, LLC

US Patent


Assay Description
A panel of four LanthaScreen JAK biochemical assays (JAK1, 2, 3 and Tyk2) were carried in a common kinase reaction buffer (50 mM HEPES, pH 7.5, 0.01%...


US Patent US10485803 (2019)

More data for this
Ligand-Target Pair
JAK3/JAK1


(Homo sapiens (Human))
BDBM279810
PNG
(1-(((1R,3s,5S)-3-((4-((5-(Hydroxymethyl)-1H-pyrazo...)
Show SMILES COc1cc(Nc2cc(CO)[nH]n2)nc(n1)N(C)[C@H]1C[C@@H]2CCC[C@H](C1)N2S(=O)(=O)N1CC(C1)C#N
Show InChI InChI=1/C22H31N9O4S/c1-29(22-25-19(9-21(26-22)35-2)24-20-6-15(13-32)27-28-20)18-7-16-4-3-5-17(8-18)31(16)36(33,34)30-11-14(10-23)12-30/h6,9,14,16-18,32H,3-5,7-8,11-13H2,1-2H3,(H2,24,25,26,27,28)/t16-,17+,18-
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0.550n/an/an/an/an/an/an/an/a



THERAVANCE BIOPHARMA R&D IP, LLC

US Patent


Assay Description
A panel of four LanthaScreen JAK biochemical assays (JAK1, 2, 3 and Tyk2) were carried in a common kinase reaction buffer (50 mM HEPES, pH 7.5, 0.01%...


US Patent US10485803 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM279813
PNG
(3-((1R,3s,5S)-3-((4-((5-(hydroxymethyl)-1H-pyrazol...)
Show SMILES COc1cc(Nc2cc(CO)[nH]n2)nc(n1)N(C)[C@H]1C[C@@H]2CC[C@H](C1)N2CCC#N
Show InChI InChI=1/C20H28N8O2/c1-27(16-9-14-4-5-15(10-16)28(14)7-3-6-21)20-23-17(11-19(24-20)30-2)22-18-8-13(12-29)25-26-18/h8,11,14-16,29H,3-5,7,9-10,12H2,1-2H3,(H2,22,23,24,25,26)/t14-,15+,16-
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0.550n/an/an/an/an/an/an/an/a



THERAVANCE BIOPHARMA R&D IP, LLC

US Patent


Assay Description
A panel of four LanthaScreen JAK biochemical assays (JAK1, 2, 3 and Tyk2) were carried in a common kinase reaction buffer (50 mM HEPES, pH 7.5, 0.01%...


US Patent US10485803 (2019)

More data for this
Ligand-Target Pair
JAK3/JAK1


(Homo sapiens (Human))
BDBM279815
PNG
(5-(((1R,3s,5S)-3-((4-((5-(hydroxymethyl)-1H-pyrazo...)
Show SMILES COc1cc(Nc2cc(CO)[nH]n2)nc(n1)N(C)[C@H]1C[C@@H]2CCC[C@H](C1)N2Cc1cncc(c1)C#N
Show InChI InChI=1/C25H31N9O2/c1-33(25-29-22(10-24(30-25)36-2)28-23-7-18(15-35)31-32-23)21-8-19-4-3-5-20(9-21)34(19)14-17-6-16(11-26)12-27-13-17/h6-7,10,12-13,19-21,35H,3-5,8-9,14-15H2,1-2H3,(H2,28,29,30,31,32)/t19-,20+,21-
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0.550n/an/an/an/an/an/an/an/a



THERAVANCE BIOPHARMA R&D IP, LLC

US Patent


Assay Description
A panel of four LanthaScreen JAK biochemical assays (JAK1, 2, 3 and Tyk2) were carried in a common kinase reaction buffer (50 mM HEPES, pH 7.5, 0.01%...


US Patent US10485803 (2019)

More data for this
Ligand-Target Pair
JAK2/TYK2


(Homo sapiens (Human))
BDBM279815
PNG
(5-(((1R,3s,5S)-3-((4-((5-(hydroxymethyl)-1H-pyrazo...)
Show SMILES COc1cc(Nc2cc(CO)[nH]n2)nc(n1)N(C)[C@H]1C[C@@H]2CCC[C@H](C1)N2Cc1cncc(c1)C#N
Show InChI InChI=1/C25H31N9O2/c1-33(25-29-22(10-24(30-25)36-2)28-23-7-18(15-35)31-32-23)21-8-19-4-3-5-20(9-21)34(19)14-17-6-16(11-26)12-27-13-17/h6-7,10,12-13,19-21,35H,3-5,8-9,14-15H2,1-2H3,(H2,28,29,30,31,32)/t19-,20+,21-
PDB

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0.550n/an/an/an/an/an/an/an/a



THERAVANCE BIOPHARMA R&D IP, LLC

US Patent


Assay Description
A panel of four LanthaScreen JAK biochemical assays (JAK1, 2, 3 and Tyk2) were carried in a common kinase reaction buffer (50 mM HEPES, pH 7.5, 0.01%...


US Patent US10485803 (2019)

More data for this
Ligand-Target Pair
JAK1/TYK2


(Homo sapiens (Human))
BDBM420046
PNG
(US10485803, Example 1-11)
Show SMILES COc1cc(Nc2cc(CO)[nH]n2)nc(N[C@H]2C[C@@H]3CCC[C@H](C2)N3S(=O)(=O)c2cccnc2)n1
Show InChI InChI=1/C22H28N8O4S/c1-34-21-11-19(25-20-10-15(13-31)28-29-20)26-22(27-21)24-14-8-16-4-2-5-17(9-14)30(16)35(32,33)18-6-3-7-23-12-18/h3,6-7,10-12,14,16-17,31H,2,4-5,8-9,13H2,1H3,(H3,24,25,26,27,28,29)/t14-,16-,17+
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THERAVANCE BIOPHARMA R&D IP, LLC

US Patent


Assay Description
A panel of four LanthaScreen JAK biochemical assays (JAK1, 2, 3 and Tyk2) were carried in a common kinase reaction buffer (50 mM HEPES, pH 7.5, 0.01%...


US Patent US10485803 (2019)

More data for this
Ligand-Target Pair
JAK1/TYK2


(Homo sapiens (Human))
BDBM420063
PNG
(US10485803, Example 2-6)
Show SMILES COc1cc(Nc2cc(CO)[nH]n2)nc(n1)N(C)[C@H]1C[C@@H]2CCC[C@H](C1)N2CC1CC1C#N
Show InChI InChI=1/C23H32N8O2/c1-30(19-8-17-4-3-5-18(9-19)31(17)12-15-6-14(15)11-24)23-26-20(10-22(27-23)33-2)25-21-7-16(13-32)28-29-21/h7,10,14-15,17-19,32H,3-6,8-9,12-13H2,1-2H3,(H2,25,26,27,28,29)/t14?,15?,17-,18+,19-
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0.550n/an/an/an/an/an/an/an/a



THERAVANCE BIOPHARMA R&D IP, LLC

US Patent


Assay Description
A panel of four LanthaScreen JAK biochemical assays (JAK1, 2, 3 and Tyk2) were carried in a common kinase reaction buffer (50 mM HEPES, pH 7.5, 0.01%...


US Patent US10485803 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM420072
PNG
(US10485803, Example 3-6)
Show SMILES COc1cc(Nc2cc(CO)[nH]n2)nc(n1)N(C)[C@H]1C[C@@H]2CCC[C@H](C1)N2C
Show InChI InChI=1/C19H29N7O2/c1-25-13-5-4-6-14(25)9-15(8-13)26(2)19-21-16(10-18(22-19)28-3)20-17-7-12(11-27)23-24-17/h7,10,13-15,27H,4-6,8-9,11H2,1-3H3,(H2,20,21,22,23,24)/t13-,14+,15-
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0.550n/an/an/an/an/an/an/an/a



THERAVANCE BIOPHARMA R&D IP, LLC

US Patent


Assay Description
A panel of four LanthaScreen JAK biochemical assays (JAK1, 2, 3 and Tyk2) were carried in a common kinase reaction buffer (50 mM HEPES, pH 7.5, 0.01%...


US Patent US10485803 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM420073
PNG
(US10485803, Example 3-7)
Show SMILES COc1cc(Nc2cc(CO)[nH]n2)nc(n1)N(C)[C@H]1C[C@@H]2CCC[C@H](C1)N2C1CCCC1
Show InChI InChI=1/C23H35N7O2/c1-29(19-11-17-8-5-9-18(12-19)30(17)16-6-3-4-7-16)23-25-20(13-22(26-23)32-2)24-21-10-15(14-31)27-28-21/h10,13,16-19,31H,3-9,11-12,14H2,1-2H3,(H2,24,25,26,27,28)/t17-,18+,19-
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0.550n/an/an/an/an/an/an/an/a



THERAVANCE BIOPHARMA R&D IP, LLC

US Patent


Assay Description
A panel of four LanthaScreen JAK biochemical assays (JAK1, 2, 3 and Tyk2) were carried in a common kinase reaction buffer (50 mM HEPES, pH 7.5, 0.01%...


US Patent US10485803 (2019)

More data for this
Ligand-Target Pair
JAK2/TYK2


(Homo sapiens (Human))
BDBM420073
PNG
(US10485803, Example 3-7)
Show SMILES COc1cc(Nc2cc(CO)[nH]n2)nc(n1)N(C)[C@H]1C[C@@H]2CCC[C@H](C1)N2C1CCCC1
Show InChI InChI=1/C23H35N7O2/c1-29(19-11-17-8-5-9-18(12-19)30(17)16-6-3-4-7-16)23-25-20(13-22(26-23)32-2)24-21-10-15(14-31)27-28-21/h10,13,16-19,31H,3-9,11-12,14H2,1-2H3,(H2,24,25,26,27,28)/t17-,18+,19-
PDB

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THERAVANCE BIOPHARMA R&D IP, LLC

US Patent


Assay Description
A panel of four LanthaScreen JAK biochemical assays (JAK1, 2, 3 and Tyk2) were carried in a common kinase reaction buffer (50 mM HEPES, pH 7.5, 0.01%...


US Patent US10485803 (2019)

More data for this
Ligand-Target Pair
JAK1/TYK2


(Homo sapiens (Human))
BDBM279816
PNG
(Isobutyl (1R,3s,5S)-3-((4-((5-(hydroxymethyl)-1H-p...)
Show SMILES COc1cc(Nc2cc(CO)[nH]n2)nc(n1)N(C)[C@H]1C[C@@H]2CCC[C@H](C1)N2C(=O)OCC(C)C
Show InChI InChI=1/C23H35N7O4/c1-14(2)13-34-23(32)30-16-6-5-7-17(30)10-18(9-16)29(3)22-25-19(11-21(26-22)33-4)24-20-8-15(12-31)27-28-20/h8,11,14,16-18,31H,5-7,9-10,12-13H2,1-4H3,(H2,24,25,26,27,28)/t16-,17+,18-
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0.550n/an/an/an/an/an/an/an/a



THERAVANCE BIOPHARMA R&D IP, LLC

US Patent


Assay Description
A panel of four LanthaScreen JAK biochemical assays (JAK1, 2, 3 and Tyk2) were carried in a common kinase reaction buffer (50 mM HEPES, pH 7.5, 0.01%...


US Patent US10485803 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM420035
PNG
(US10485803, Example 9)
Show SMILES COc1cc(Nc2cc(CO)[nH]n2)nc(n1)N(C)[C@H]1C[C@@H]2CCC[C@H](C1)N2C(=O)C(F)F
Show InChI InChI=1/C20H27F2N7O3/c1-28(14-7-12-4-3-5-13(8-14)29(12)19(31)18(21)22)20-24-15(9-17(25-20)32-2)23-16-6-11(10-30)26-27-16/h6,9,12-14,18,30H,3-5,7-8,10H2,1-2H3,(H2,23,24,25,26,27)/t12-,13+,14-
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THERAVANCE BIOPHARMA R&D IP, LLC

US Patent


Assay Description
A panel of four LanthaScreen JAK biochemical assays (JAK1, 2, 3 and Tyk2) were carried in a common kinase reaction buffer (50 mM HEPES, pH 7.5, 0.01%...


US Patent US10485803 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM279829
PNG
(US10028960, Example 1-12 | US10485803, Example 1-1...)
Show SMILES COc1cc(Nc2cc(CO)[nH]n2)nc(n1)N(C)[C@H]1C[C@@H]2CCC[C@H](C1)N2S(=O)(=O)CCC#N
Show InChI InChI=1/C21H30N8O4S/c1-28(17-10-15-5-3-6-16(11-17)29(15)34(31,32)8-4-7-22)21-24-18(12-20(25-21)33-2)23-19-9-14(13-30)26-27-19/h9,12,15-17,30H,3-6,8,10-11,13H2,1-2H3,(H2,23,24,25,26,27)/t15-,16+,17-
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0.550n/an/an/an/an/an/an/an/a



THERAVANCE BIOPHARMA R&D IP, LLC

US Patent


Assay Description
A panel of four LanthaScreen JAK biochemical assays (JAK1, 2, 3 and Tyk2) were carried in a common kinase reaction buffer (50 mM HEPES, pH 7.5, 0.01%...


US Patent US10485803 (2019)

More data for this
Ligand-Target Pair
JAK3/JAK1


(Homo sapiens (Human))
BDBM279830
PNG
(US10028960, Example 1-13 | US10485803, Example 1-1...)
Show SMILES COc1cc(Nc2cc(CO)[nH]n2)nc(n1)N(C)[C@H]1C[C@@H]2CCC[C@H](C1)N2S(=O)(=O)N1CCCC1
Show InChI InChI=1/C22H34N8O4S/c1-28(22-24-19(13-21(25-22)34-2)23-20-10-15(14-31)26-27-20)18-11-16-6-5-7-17(12-18)30(16)35(32,33)29-8-3-4-9-29/h10,13,16-18,31H,3-9,11-12,14H2,1-2H3,(H2,23,24,25,26,27)/t16-,17+,18-
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0.550n/an/an/an/an/an/an/an/a



THERAVANCE BIOPHARMA R&D IP, LLC

US Patent


Assay Description
A panel of four LanthaScreen JAK biochemical assays (JAK1, 2, 3 and Tyk2) were carried in a common kinase reaction buffer (50 mM HEPES, pH 7.5, 0.01%...


US Patent US10485803 (2019)

More data for this
Ligand-Target Pair
JAK2/TYK2


(Homo sapiens (Human))
BDBM279834
PNG
(US10028960, Example 1-17 | US10485803, Example 1-1...)
Show SMILES COc1cc(Nc2cc(CO)[nH]n2)nc(n1)N(C)[C@H]1C[C@@H]2CCC[C@H](C1)N2S(=O)(=O)N1CCC1
Show InChI InChI=1/C21H32N8O4S/c1-27(21-23-18(12-20(24-21)33-2)22-19-9-14(13-30)25-26-19)17-10-15-5-3-6-16(11-17)29(15)34(31,32)28-7-4-8-28/h9,12,15-17,30H,3-8,10-11,13H2,1-2H3,(H2,22,23,24,25,26)/t15-,16+,17-
PDB

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THERAVANCE BIOPHARMA R&D IP, LLC

US Patent


Assay Description
A panel of four LanthaScreen JAK biochemical assays (JAK1, 2, 3 and Tyk2) were carried in a common kinase reaction buffer (50 mM HEPES, pH 7.5, 0.01%...


US Patent US10485803 (2019)

More data for this
Ligand-Target Pair
JAK1/TYK2


(Homo sapiens (Human))
BDBM279839
PNG
(US10028960, Example 2-3 | US10485803, Example 2-3)
Show SMILES COc1cc(Nc2cc(CO)[nH]n2)nc(N[C@H]2C[C@@H]3CCC[C@H](C2)N3Cc2ccnc(c2)C#N)n1
Show InChI InChI=1/C24H29N9O2/c1-35-23-11-21(28-22-10-18(14-34)31-32-22)29-24(30-23)27-16-8-19-3-2-4-20(9-16)33(19)13-15-5-6-26-17(7-15)12-25/h5-7,10-11,16,19-20,34H,2-4,8-9,13-14H2,1H3,(H3,27,28,29,30,31,32)/t16-,19-,20+
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0.550n/an/an/an/an/an/an/an/a



THERAVANCE BIOPHARMA R&D IP, LLC

US Patent


Assay Description
A panel of four LanthaScreen JAK biochemical assays (JAK1, 2, 3 and Tyk2) were carried in a common kinase reaction buffer (50 mM HEPES, pH 7.5, 0.01%...


US Patent US10485803 (2019)

More data for this
Ligand-Target Pair
JAK1/TYK2


(Homo sapiens (Human))
BDBM279844
PNG
(US10028960, Example 2-8 | US10485803, Example 2-8)
Show SMILES COc1cc(Nc2cc(CO)[nH]n2)nc(n1)N(C)[C@H]1C[C@@H]2CCC[C@H](C1)N2Cc1ccnc(c1)C#N
Show InChI InChI=1/C25H31N9O2/c1-33(25-29-22(12-24(30-25)36-2)28-23-9-18(15-35)31-32-23)21-10-19-4-3-5-20(11-21)34(19)14-16-6-7-27-17(8-16)13-26/h6-9,12,19-21,35H,3-5,10-11,14-15H2,1-2H3,(H2,28,29,30,31,32)/t19-,20+,21-
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0.550n/an/an/an/an/an/an/an/a



THERAVANCE BIOPHARMA R&D IP, LLC

US Patent


Assay Description
A panel of four LanthaScreen JAK biochemical assays (JAK1, 2, 3 and Tyk2) were carried in a common kinase reaction buffer (50 mM HEPES, pH 7.5, 0.01%...


US Patent US10485803 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM420068
PNG
(US10485803, Example 3-2)
Show SMILES CCC(C)OC(=O)N1[C@H]2CCC[C@@H]1C[C@H](C2)N(C)c1nc(Nc2cc(CO)[nH]n2)cc(OC)n1
Show InChI InChI=1/C23H35N7O4/c1-5-14(2)34-23(32)30-16-7-6-8-17(30)11-18(10-16)29(3)22-25-19(12-21(26-22)33-4)24-20-9-15(13-31)27-28-20/h9,12,14,16-18,31H,5-8,10-11,13H2,1-4H3,(H2,24,25,26,27,28)/t14?,16-,17+,18-
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THERAVANCE BIOPHARMA R&D IP, LLC

US Patent


Assay Description
A panel of four LanthaScreen JAK biochemical assays (JAK1, 2, 3 and Tyk2) were carried in a common kinase reaction buffer (50 mM HEPES, pH 7.5, 0.01%...


US Patent US10485803 (2019)

More data for this
Ligand-Target Pair
JAK1/TYK2


(Homo sapiens (Human))
BDBM420074
PNG
(US10485803, Example 3-8)
Show SMILES COc1cc(Nc2cc(CO)[nH]n2)nc(n1)N(C)[C@H]1C[C@@H]2CCC[C@H](C1)N2C1CCC1
Show InChI InChI=1/C22H33N7O2/c1-28(18-10-16-7-4-8-17(11-18)29(16)15-5-3-6-15)22-24-19(12-21(25-22)31-2)23-20-9-14(13-30)26-27-20/h9,12,15-18,30H,3-8,10-11,13H2,1-2H3,(H2,23,24,25,26,27)/t16-,17+,18-
PDB

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THERAVANCE BIOPHARMA R&D IP, LLC

US Patent


Assay Description
A panel of four LanthaScreen JAK biochemical assays (JAK1, 2, 3 and Tyk2) were carried in a common kinase reaction buffer (50 mM HEPES, pH 7.5, 0.01%...


US Patent US10485803 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM420074
PNG
(US10485803, Example 3-8)
Show SMILES COc1cc(Nc2cc(CO)[nH]n2)nc(n1)N(C)[C@H]1C[C@@H]2CCC[C@H](C1)N2C1CCC1
Show InChI InChI=1/C22H33N7O2/c1-28(18-10-16-7-4-8-17(11-18)29(16)15-5-3-6-15)22-24-19(12-21(25-22)31-2)23-20-9-14(13-30)26-27-20/h9,12,15-18,30H,3-8,10-11,13H2,1-2H3,(H2,23,24,25,26,27)/t16-,17+,18-
PDB

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THERAVANCE BIOPHARMA R&D IP, LLC

US Patent


Assay Description
A panel of four LanthaScreen JAK biochemical assays (JAK1, 2, 3 and Tyk2) were carried in a common kinase reaction buffer (50 mM HEPES, pH 7.5, 0.01%...


US Patent US10485803 (2019)

More data for this
Ligand-Target Pair
JAK1/TYK2


(Homo sapiens (Human))
BDBM279814
PNG
(5-(((1R,3s,5S)-3-((4-((5-(hydroxymethyl)-1H-pyrazo...)
Show SMILES COc1cc(Nc2cc(CO)[nH]n2)nc(N[C@H]2C[C@@H]3CCC[C@H](C2)N3Cc2ccc(nc2)C#N)n1
Show InChI InChI=1/C24H29N9O2/c1-35-23-10-21(28-22-9-18(14-34)31-32-22)29-24(30-23)27-17-7-19-3-2-4-20(8-17)33(19)13-15-5-6-16(11-25)26-12-15/h5-6,9-10,12,17,19-20,34H,2-4,7-8,13-14H2,1H3,(H3,27,28,29,30,31,32)/t17-,19-,20+
PDB

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THERAVANCE BIOPHARMA R&D IP, LLC

US Patent


Assay Description
A panel of four LanthaScreen JAK biochemical assays (JAK1, 2, 3 and Tyk2) were carried in a common kinase reaction buffer (50 mM HEPES, pH 7.5, 0.01%...


US Patent US10485803 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM279816
PNG
(Isobutyl (1R,3s,5S)-3-((4-((5-(hydroxymethyl)-1H-p...)
Show SMILES COc1cc(Nc2cc(CO)[nH]n2)nc(n1)N(C)[C@H]1C[C@@H]2CCC[C@H](C1)N2C(=O)OCC(C)C
Show InChI InChI=1/C23H35N7O4/c1-14(2)13-34-23(32)30-16-6-5-7-17(30)10-18(9-16)29(3)22-25-19(11-21(26-22)33-4)24-20-8-15(12-31)27-28-20/h8,11,14,16-18,31H,5-7,9-10,12-13H2,1-4H3,(H2,24,25,26,27,28)/t16-,17+,18-
PDB

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0.550n/an/an/an/an/an/an/an/a



THERAVANCE BIOPHARMA R&D IP, LLC

US Patent


Assay Description
A panel of four LanthaScreen JAK biochemical assays (JAK1, 2, 3 and Tyk2) were carried in a common kinase reaction buffer (50 mM HEPES, pH 7.5, 0.01%...


US Patent US10485803 (2019)

More data for this
Ligand-Target Pair
JAK1/TYK2


(Homo sapiens (Human))
BDBM279822
PNG
(US10028960, Example 1-5 | US10485803, Example 1-5)
Show SMILES COc1cc(Nc2cc(CO)[nH]n2)nc(N[C@H]2C[C@@H]3CCC[C@H](C2)N3S(=O)(=O)N2CCC2)n1
Show InChI InChI=1/C20H30N8O4S/c1-32-19-11-17(22-18-10-14(12-29)25-26-18)23-20(24-19)21-13-8-15-4-2-5-16(9-13)28(15)33(30,31)27-6-3-7-27/h10-11,13,15-16,29H,2-9,12H2,1H3,(H3,21,22,23,24,25,26)/t13-,15-,16+
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0.550n/an/an/an/an/an/an/an/a



THERAVANCE BIOPHARMA R&D IP, LLC

US Patent


Assay Description
A panel of four LanthaScreen JAK biochemical assays (JAK1, 2, 3 and Tyk2) were carried in a common kinase reaction buffer (50 mM HEPES, pH 7.5, 0.01%...


US Patent US10485803 (2019)

More data for this
Ligand-Target Pair
JAK2/TYK2


(Homo sapiens (Human))
BDBM279830
PNG
(US10028960, Example 1-13 | US10485803, Example 1-1...)
Show SMILES COc1cc(Nc2cc(CO)[nH]n2)nc(n1)N(C)[C@H]1C[C@@H]2CCC[C@H](C1)N2S(=O)(=O)N1CCCC1
Show InChI InChI=1/C22H34N8O4S/c1-28(22-24-19(13-21(25-22)34-2)23-20-10-15(14-31)26-27-20)18-11-16-6-5-7-17(12-18)30(16)35(32,33)29-8-3-4-9-29/h10,13,16-18,31H,3-9,11-12,14H2,1-2H3,(H2,23,24,25,26,27)/t16-,17+,18-
PDB

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0.550n/an/an/an/an/an/an/an/a



THERAVANCE BIOPHARMA R&D IP, LLC

US Patent


Assay Description
A panel of four LanthaScreen JAK biochemical assays (JAK1, 2, 3 and Tyk2) were carried in a common kinase reaction buffer (50 mM HEPES, pH 7.5, 0.01%...


US Patent US10485803 (2019)

More data for this
Ligand-Target Pair
JAK1/TYK2


(Homo sapiens (Human))
BDBM279841
PNG
(US10028960, Example 2-5 | US10485803, Example 2-5)
Show SMILES COc1cc(Nc2cc(CO)[nH]n2)nc(n1)N(C)[C@H]1C[C@@H]2CCC[C@H](C1)N2CCC#N
Show InChI InChI=1/C21H30N8O2/c1-28(17-10-15-5-3-6-16(11-17)29(15)8-4-7-22)21-24-18(12-20(25-21)31-2)23-19-9-14(13-30)26-27-19/h9,12,15-17,30H,3-6,8,10-11,13H2,1-2H3,(H2,23,24,25,26,27)/t15-,16+,17-
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0.550n/an/an/an/an/an/an/an/a



THERAVANCE BIOPHARMA R&D IP, LLC

US Patent


Assay Description
A panel of four LanthaScreen JAK biochemical assays (JAK1, 2, 3 and Tyk2) were carried in a common kinase reaction buffer (50 mM HEPES, pH 7.5, 0.01%...


US Patent US10485803 (2019)

More data for this
Ligand-Target Pair
JAK1/TYK2


(Homo sapiens (Human))
BDBM420068
PNG
(US10485803, Example 3-2)
Show SMILES CCC(C)OC(=O)N1[C@H]2CCC[C@@H]1C[C@H](C2)N(C)c1nc(Nc2cc(CO)[nH]n2)cc(OC)n1
Show InChI InChI=1/C23H35N7O4/c1-5-14(2)34-23(32)30-16-7-6-8-17(30)11-18(10-16)29(3)22-25-19(12-21(26-22)33-4)24-20-9-15(13-31)27-28-20/h9,12,14,16-18,31H,5-8,10-11,13H2,1-4H3,(H2,24,25,26,27,28)/t14?,16-,17+,18-
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0.550n/an/an/an/an/an/an/an/a



THERAVANCE BIOPHARMA R&D IP, LLC

US Patent


Assay Description
A panel of four LanthaScreen JAK biochemical assays (JAK1, 2, 3 and Tyk2) were carried in a common kinase reaction buffer (50 mM HEPES, pH 7.5, 0.01%...


US Patent US10485803 (2019)

More data for this
Ligand-Target Pair
JAK1/TYK2


(Homo sapiens (Human))
BDBM420071
PNG
(US10485803, Example 3-5)
Show SMILES COc1cc(Nc2cc(CO)[nH]n2)nc(n1)N(C)[C@H]1C[C@@H]2CCC[C@H](C1)N2C(=O)C1CC1
Show InChI InChI=1/C22H31N7O3/c1-28(17-9-15-4-3-5-16(10-17)29(15)21(31)13-6-7-13)22-24-18(11-20(25-22)32-2)23-19-8-14(12-30)26-27-19/h8,11,13,15-17,30H,3-7,9-10,12H2,1-2H3,(H2,23,24,25,26,27)/t15-,16+,17-
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THERAVANCE BIOPHARMA R&D IP, LLC

US Patent


Assay Description
A panel of four LanthaScreen JAK biochemical assays (JAK1, 2, 3 and Tyk2) were carried in a common kinase reaction buffer (50 mM HEPES, pH 7.5, 0.01%...


US Patent US10485803 (2019)

More data for this
Ligand-Target Pair
JAK1/TYK2


(Homo sapiens (Human))
BDBM279829
PNG
(US10028960, Example 1-12 | US10485803, Example 1-1...)
Show SMILES COc1cc(Nc2cc(CO)[nH]n2)nc(n1)N(C)[C@H]1C[C@@H]2CCC[C@H](C1)N2S(=O)(=O)CCC#N
Show InChI InChI=1/C21H30N8O4S/c1-28(17-10-15-5-3-6-16(11-17)29(15)34(31,32)8-4-7-22)21-24-18(12-20(25-21)33-2)23-19-9-14(13-30)26-27-19/h9,12,15-17,30H,3-6,8,10-11,13H2,1-2H3,(H2,23,24,25,26,27)/t15-,16+,17-
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0.550n/an/an/an/an/an/an/an/a



THERAVANCE BIOPHARMA R&D IP, LLC

US Patent


Assay Description
A panel of four LanthaScreen JAK biochemical assays (JAK1, 2, 3 and Tyk2) were carried in a common kinase reaction buffer (50 mM HEPES, pH 7.5, 0.01%...


US Patent US10485803 (2019)

More data for this
Ligand-Target Pair
JAK1/TYK2


(Homo sapiens (Human))
BDBM279831
PNG
(US10028960, Example 1-14 | US10485803, Example 1-1...)
Show SMILES COc1cc(Nc2cc(CO)[nH]n2)nc(n1)N(C)[C@H]1C[C@@H]2CCC[C@H](C1)N2S(=O)(=O)C1CC1
Show InChI InChI=1/C21H31N7O4S/c1-27(16-9-14-4-3-5-15(10-16)28(14)33(30,31)17-6-7-17)21-23-18(11-20(24-21)32-2)22-19-8-13(12-29)25-26-19/h8,11,14-17,29H,3-7,9-10,12H2,1-2H3,(H2,22,23,24,25,26)/t14-,15+,16-
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0.550n/an/an/an/an/an/an/an/a



THERAVANCE BIOPHARMA R&D IP, LLC

US Patent


Assay Description
A panel of four LanthaScreen JAK biochemical assays (JAK1, 2, 3 and Tyk2) were carried in a common kinase reaction buffer (50 mM HEPES, pH 7.5, 0.01%...


US Patent US10485803 (2019)

More data for this
Ligand-Target Pair
JAK1/TYK2


(Homo sapiens (Human))
BDBM279832
PNG
(US10028960, Example 1-15 | US10485803, Example 1-1...)
Show SMILES COc1cc(Nc2cc(CO)[nH]n2)nc(n1)N(C)[C@H]1C[C@@H]2CCC[C@H](C1)N2S(=O)(=O)c1cccnc1
Show InChI InChI=1/C23H30N8O4S/c1-30(23-26-20(12-22(27-23)35-2)25-21-9-15(14-32)28-29-21)18-10-16-5-3-6-17(11-18)31(16)36(33,34)19-7-4-8-24-13-19/h4,7-9,12-13,16-18,32H,3,5-6,10-11,14H2,1-2H3,(H2,25,26,27,28,29)/t16-,17+,18-
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0.550n/an/an/an/an/an/an/an/a



THERAVANCE BIOPHARMA R&D IP, LLC

US Patent


Assay Description
A panel of four LanthaScreen JAK biochemical assays (JAK1, 2, 3 and Tyk2) were carried in a common kinase reaction buffer (50 mM HEPES, pH 7.5, 0.01%...


US Patent US10485803 (2019)

More data for this
Ligand-Target Pair
JAK2/TYK2


(Homo sapiens (Human))
BDBM279832
PNG
(US10028960, Example 1-15 | US10485803, Example 1-1...)
Show SMILES COc1cc(Nc2cc(CO)[nH]n2)nc(n1)N(C)[C@H]1C[C@@H]2CCC[C@H](C1)N2S(=O)(=O)c1cccnc1
Show InChI InChI=1/C23H30N8O4S/c1-30(23-26-20(12-22(27-23)35-2)25-21-9-15(14-32)28-29-21)18-10-16-5-3-6-17(11-18)31(16)36(33,34)19-7-4-8-24-13-19/h4,7-9,12-13,16-18,32H,3,5-6,10-11,14H2,1-2H3,(H2,25,26,27,28,29)/t16-,17+,18-
PDB

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0.550n/an/an/an/an/an/an/an/a



THERAVANCE BIOPHARMA R&D IP, LLC

US Patent


Assay Description
A panel of four LanthaScreen JAK biochemical assays (JAK1, 2, 3 and Tyk2) were carried in a common kinase reaction buffer (50 mM HEPES, pH 7.5, 0.01%...


US Patent US10485803 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM279833
PNG
(US10028960, Example 1-16 | US10485803, Example 1-1...)
Show SMILES COc1cc(Nc2cc(CO)[nH]n2)nc(n1)N(C)[C@H]1C[C@@H]2CCC[C@H](C1)N2S(=O)(=O)c1ccccc1
Show InChI InChI=1/C24H31N7O4S/c1-30(24-26-21(14-23(27-24)35-2)25-22-11-16(15-32)28-29-22)19-12-17-7-6-8-18(13-19)31(17)36(33,34)20-9-4-3-5-10-20/h3-5,9-11,14,17-19,32H,6-8,12-13,15H2,1-2H3,(H2,25,26,27,28,29)/t17-,18+,19-
PDB

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0.550n/an/an/an/an/an/an/an/a



THERAVANCE BIOPHARMA R&D IP, LLC

US Patent


Assay Description
A panel of four LanthaScreen JAK biochemical assays (JAK1, 2, 3 and Tyk2) were carried in a common kinase reaction buffer (50 mM HEPES, pH 7.5, 0.01%...


US Patent US10485803 (2019)

More data for this
Ligand-Target Pair
JAK1/TYK2


(Homo sapiens (Human))
BDBM279838
PNG
(US10028960, Example 2-2 | US10485803, Example 2-4)
Show SMILES COc1cc(Nc2cc(CO)[nH]n2)nc(N[C@H]2C[C@@H]3CCC[C@H](C2)N3Cc2ccncc2)n1
Show InChI InChI=1/C23H30N8O2/c1-33-22-12-20(26-21-11-17(14-32)29-30-21)27-23(28-22)25-16-9-18-3-2-4-19(10-16)31(18)13-15-5-7-24-8-6-15/h5-8,11-12,16,18-19,32H,2-4,9-10,13-14H2,1H3,(H3,25,26,27,28,29,30)/t16-,18-,19+
PDB

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0.550n/an/an/an/an/an/an/an/a



THERAVANCE BIOPHARMA R&D IP, LLC

US Patent


Assay Description
A panel of four LanthaScreen JAK biochemical assays (JAK1, 2, 3 and Tyk2) were carried in a common kinase reaction buffer (50 mM HEPES, pH 7.5, 0.01%...


US Patent US10485803 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM420063
PNG
(US10485803, Example 2-6)
Show SMILES COc1cc(Nc2cc(CO)[nH]n2)nc(n1)N(C)[C@H]1C[C@@H]2CCC[C@H](C1)N2CC1CC1C#N
Show InChI InChI=1/C23H32N8O2/c1-30(19-8-17-4-3-5-18(9-19)31(17)12-15-6-14(15)11-24)23-26-20(10-22(27-23)33-2)25-21-7-16(13-32)28-29-21/h7,10,14-15,17-19,32H,3-6,8-9,12-13H2,1-2H3,(H2,25,26,27,28,29)/t14?,15?,17-,18+,19-
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THERAVANCE BIOPHARMA R&D IP, LLC

US Patent


Assay Description
A panel of four LanthaScreen JAK biochemical assays (JAK1, 2, 3 and Tyk2) were carried in a common kinase reaction buffer (50 mM HEPES, pH 7.5, 0.01%...


US Patent US10485803 (2019)

More data for this
Ligand-Target Pair
JAK1/TYK2


(Homo sapiens (Human))
BDBM279848
PNG
(US10028960, Example 3-3 | US10485803, Example 3-3)
Show SMILES COC(=O)N1[C@H]2CCC[C@@H]1C[C@H](C2)N(C)c1nc(Nc2cc(CO)[nH]n2)cc(OC)n1
Show InChI InChI=1/C20H29N7O4/c1-26(15-8-13-5-4-6-14(9-15)27(13)20(29)31-3)19-22-16(10-18(23-19)30-2)21-17-7-12(11-28)24-25-17/h7,10,13-15,28H,4-6,8-9,11H2,1-3H3,(H2,21,22,23,24,25)/t13-,14+,15-
PDB

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0.550n/an/an/an/an/an/an/an/a



THERAVANCE BIOPHARMA R&D IP, LLC

US Patent


Assay Description
A panel of four LanthaScreen JAK biochemical assays (JAK1, 2, 3 and Tyk2) were carried in a common kinase reaction buffer (50 mM HEPES, pH 7.5, 0.01%...


US Patent US10485803 (2019)

More data for this
Ligand-Target Pair
JAK2/TYK2


(Homo sapiens (Human))
BDBM279849
PNG
(US10028960, Example 3-4 | US10485803, Example 3-4)
Show SMILES COc1cc(Nc2cc(CO)[nH]n2)nc(n1)N(C)[C@H]1C[C@@H]2CCC[C@H](C1)N2C(=O)N1CCOCC1
Show InChI InChI=1/C23H34N8O4/c1-29(22-25-19(13-21(26-22)34-2)24-20-10-15(14-32)27-28-20)18-11-16-4-3-5-17(12-18)31(16)23(33)30-6-8-35-9-7-30/h10,13,16-18,32H,3-9,11-12,14H2,1-2H3,(H2,24,25,26,27,28)/t16-,17+,18-
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0.550n/an/an/an/an/an/an/an/a



THERAVANCE BIOPHARMA R&D IP, LLC

US Patent


Assay Description
A panel of four LanthaScreen JAK biochemical assays (JAK1, 2, 3 and Tyk2) were carried in a common kinase reaction buffer (50 mM HEPES, pH 7.5, 0.01%...


US Patent US10485803 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM420071
PNG
(US10485803, Example 3-5)
Show SMILES COc1cc(Nc2cc(CO)[nH]n2)nc(n1)N(C)[C@H]1C[C@@H]2CCC[C@H](C1)N2C(=O)C1CC1
Show InChI InChI=1/C22H31N7O3/c1-28(17-9-15-4-3-5-16(10-17)29(15)21(31)13-6-7-13)22-24-18(11-20(25-22)32-2)23-19-8-14(12-30)26-27-19/h8,11,13,15-17,30H,3-7,9-10,12H2,1-2H3,(H2,23,24,25,26,27)/t15-,16+,17-
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THERAVANCE BIOPHARMA R&D IP, LLC

US Patent


Assay Description
A panel of four LanthaScreen JAK biochemical assays (JAK1, 2, 3 and Tyk2) were carried in a common kinase reaction buffer (50 mM HEPES, pH 7.5, 0.01%...


US Patent US10485803 (2019)

More data for this
Ligand-Target Pair
JAK1/TYK2


(Homo sapiens (Human))
BDBM420073
PNG
(US10485803, Example 3-7)
Show SMILES COc1cc(Nc2cc(CO)[nH]n2)nc(n1)N(C)[C@H]1C[C@@H]2CCC[C@H](C1)N2C1CCCC1
Show InChI InChI=1/C23H35N7O2/c1-29(19-11-17-8-5-9-18(12-19)30(17)16-6-3-4-7-16)23-25-20(13-22(26-23)32-2)24-21-10-15(14-31)27-28-21/h10,13,16-19,31H,3-9,11-12,14H2,1-2H3,(H2,24,25,26,27,28)/t17-,18+,19-
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THERAVANCE BIOPHARMA R&D IP, LLC

US Patent


Assay Description
A panel of four LanthaScreen JAK biochemical assays (JAK1, 2, 3 and Tyk2) were carried in a common kinase reaction buffer (50 mM HEPES, pH 7.5, 0.01%...


US Patent US10485803 (2019)

More data for this
Ligand-Target Pair
JAK2/TYK2


(Homo sapiens (Human))
BDBM279812
PNG
((3-((6-methoxy-2-(((1R,3s,5S)-9-((2-methoxyethyl)s...)
Show SMILES COCCS(=O)(=O)N1[C@H]2CCC[C@@H]1C[C@H](C2)N(C)c1nc(Nc2cc(CO)[nH]n2)cc(OC)n1
Show InChI InChI=1/C21H33N7O5S/c1-27(17-10-15-5-4-6-16(11-17)28(15)34(30,31)8-7-32-2)21-23-18(12-20(24-21)33-3)22-19-9-14(13-29)25-26-19/h9,12,15-17,29H,4-8,10-11,13H2,1-3H3,(H2,22,23,24,25,26)/t15-,16+,17-
PDB

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THERAVANCE BIOPHARMA R&D IP, LLC

US Patent


Assay Description
A panel of four LanthaScreen JAK biochemical assays (JAK1, 2, 3 and Tyk2) were carried in a common kinase reaction buffer (50 mM HEPES, pH 7.5, 0.01%...


US Patent US10485803 (2019)

More data for this
Ligand-Target Pair
JAK1/TYK2


(Homo sapiens (Human))
BDBM420045
PNG
(US10485803, Example 1-10)
Show SMILES COc1cc(Nc2cc(CO)[nH]n2)nc(N[C@H]2C[C@@H]3CCC[C@H](C2)N3S(=O)(=O)C2CC2)n1
Show InChI InChI=1/C20H29N7O4S/c1-31-19-10-17(22-18-9-13(11-28)25-26-18)23-20(24-19)21-12-7-14-3-2-4-15(8-12)27(14)32(29,30)16-5-6-16/h9-10,12,14-16,28H,2-8,11H2,1H3,(H3,21,22,23,24,25,26)/t12-,14-,15+
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THERAVANCE BIOPHARMA R&D IP, LLC

US Patent


Assay Description
A panel of four LanthaScreen JAK biochemical assays (JAK1, 2, 3 and Tyk2) were carried in a common kinase reaction buffer (50 mM HEPES, pH 7.5, 0.01%...


US Patent US10485803 (2019)

More data for this
Ligand-Target Pair
JAK2/TYK2


(Homo sapiens (Human))
BDBM279831
PNG
(US10028960, Example 1-14 | US10485803, Example 1-1...)
Show SMILES COc1cc(Nc2cc(CO)[nH]n2)nc(n1)N(C)[C@H]1C[C@@H]2CCC[C@H](C1)N2S(=O)(=O)C1CC1
Show InChI InChI=1/C21H31N7O4S/c1-27(16-9-14-4-3-5-15(10-16)28(14)33(30,31)17-6-7-17)21-23-18(11-20(24-21)32-2)22-19-8-13(12-29)25-26-19/h8,11,14-17,29H,3-7,9-10,12H2,1-2H3,(H2,22,23,24,25,26)/t14-,15+,16-
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0.550n/an/an/an/an/an/an/an/a



THERAVANCE BIOPHARMA R&D IP, LLC

US Patent


Assay Description
A panel of four LanthaScreen JAK biochemical assays (JAK1, 2, 3 and Tyk2) were carried in a common kinase reaction buffer (50 mM HEPES, pH 7.5, 0.01%...


US Patent US10485803 (2019)

More data for this
Ligand-Target Pair
JAK1/TYK2


(Homo sapiens (Human))
BDBM420053
PNG
(US10485803, Example 1-18)
Show SMILES COc1cc(Nc2cc(CO)[nH]n2)nc(n1)N(C)[C@H]1C[C@@H]2CCC[C@H](C1)N2S(=O)(=O)CC1CC1
Show InChI InChI=1/C22H33N7O4S/c1-28(22-24-19(11-21(25-22)33-2)23-20-8-15(12-30)26-27-20)18-9-16-4-3-5-17(10-18)29(16)34(31,32)13-14-6-7-14/h8,11,14,16-18,30H,3-7,9-10,12-13H2,1-2H3,(H2,23,24,25,26,27)/t16-,17+,18-
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THERAVANCE BIOPHARMA R&D IP, LLC

US Patent


Assay Description
A panel of four LanthaScreen JAK biochemical assays (JAK1, 2, 3 and Tyk2) were carried in a common kinase reaction buffer (50 mM HEPES, pH 7.5, 0.01%...


US Patent US10485803 (2019)

More data for this
Ligand-Target Pair
JAK1/TYK2


(Homo sapiens (Human))
BDBM279838
PNG
(US10028960, Example 2-2 | US10485803, Example 2-4)
Show SMILES COc1cc(Nc2cc(CO)[nH]n2)nc(N[C@H]2C[C@@H]3CCC[C@H](C2)N3Cc2ccncc2)n1
Show InChI InChI=1/C23H30N8O2/c1-33-22-12-20(26-21-11-17(14-32)29-30-21)27-23(28-22)25-16-9-18-3-2-4-19(10-16)31(18)13-15-5-7-24-8-6-15/h5-8,11-12,16,18-19,32H,2-4,9-10,13-14H2,1H3,(H3,25,26,27,28,29,30)/t16-,18-,19+
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0.550n/an/an/an/an/an/an/an/a



THERAVANCE BIOPHARMA R&D IP, LLC

US Patent


Assay Description
A panel of four LanthaScreen JAK biochemical assays (JAK1, 2, 3 and Tyk2) were carried in a common kinase reaction buffer (50 mM HEPES, pH 7.5, 0.01%...


US Patent US10485803 (2019)

More data for this
Ligand-Target Pair
JAK1/TYK2


(Homo sapiens (Human))
BDBM279811
PNG
((3-((6-methoxy-2-(methyl((1R,3s,5S)-9-(methylsulfo...)
Show SMILES COc1cc(Nc2cc(CO)[nH]n2)nc(n1)N(C)[C@H]1C[C@@H]2CCC[C@H](C1)N2S(C)(=O)=O
Show InChI InChI=1/C19H29N7O4S/c1-25(15-8-13-5-4-6-14(9-15)26(13)31(3,28)29)19-21-16(10-18(22-19)30-2)20-17-7-12(11-27)23-24-17/h7,10,13-15,27H,4-6,8-9,11H2,1-3H3,(H2,20,21,22,23,24)/t13-,14+,15-
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0.550n/an/an/an/an/an/an/an/a



THERAVANCE BIOPHARMA R&D IP, LLC

US Patent


Assay Description
A panel of four LanthaScreen JAK biochemical assays (JAK1, 2, 3 and Tyk2) were carried in a common kinase reaction buffer (50 mM HEPES, pH 7.5, 0.01%...


US Patent US10485803 (2019)

More data for this
Ligand-Target Pair
JAK2/TYK2


(Homo sapiens (Human))
BDBM279811
PNG
((3-((6-methoxy-2-(methyl((1R,3s,5S)-9-(methylsulfo...)
Show SMILES COc1cc(Nc2cc(CO)[nH]n2)nc(n1)N(C)[C@H]1C[C@@H]2CCC[C@H](C1)N2S(C)(=O)=O
Show InChI InChI=1/C19H29N7O4S/c1-25(15-8-13-5-4-6-14(9-15)26(13)31(3,28)29)19-21-16(10-18(22-19)30-2)20-17-7-12(11-27)23-24-17/h7,10,13-15,27H,4-6,8-9,11H2,1-3H3,(H2,20,21,22,23,24)/t13-,14+,15-
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0.550n/an/an/an/an/an/an/an/a



THERAVANCE BIOPHARMA R&D IP, LLC

US Patent


Assay Description
A panel of four LanthaScreen JAK biochemical assays (JAK1, 2, 3 and Tyk2) were carried in a common kinase reaction buffer (50 mM HEPES, pH 7.5, 0.01%...


US Patent US10485803 (2019)

More data for this
Ligand-Target Pair
JAK1/TYK2


(Homo sapiens (Human))
BDBM420035
PNG
(US10485803, Example 9)
Show SMILES COc1cc(Nc2cc(CO)[nH]n2)nc(n1)N(C)[C@H]1C[C@@H]2CCC[C@H](C1)N2C(=O)C(F)F
Show InChI InChI=1/C20H27F2N7O3/c1-28(14-7-12-4-3-5-13(8-14)29(12)19(31)18(21)22)20-24-15(9-17(25-20)32-2)23-16-6-11(10-30)26-27-16/h6,9,12-14,18,30H,3-5,7-8,10H2,1-2H3,(H2,23,24,25,26,27)/t12-,13+,14-
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THERAVANCE BIOPHARMA R&D IP, LLC

US Patent


Assay Description
A panel of four LanthaScreen JAK biochemical assays (JAK1, 2, 3 and Tyk2) were carried in a common kinase reaction buffer (50 mM HEPES, pH 7.5, 0.01%...


US Patent US10485803 (2019)

More data for this
Ligand-Target Pair
JAK1/TYK2


(Homo sapiens (Human))
BDBM279819
PNG
(US10028960, Example 1-2 | US10485803, Example 1-2)
Show SMILES COc1cc(Nc2cc(CO)[nH]n2)nc(N[C@H]2C[C@@H]3CC[C@H](C2)N3S(=O)(=O)N2CC(C2)C#N)n1
Show InChI InChI=1/C20H27N9O4S/c1-33-19-7-17(23-18-6-14(11-30)26-27-18)24-20(25-19)22-13-4-15-2-3-16(5-13)29(15)34(31,32)28-9-12(8-21)10-28/h6-7,12-13,15-16,30H,2-5,9-11H2,1H3,(H3,22,23,24,25,26,27)/t13-,15-,16+
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0.550n/an/an/an/an/an/an/an/a



THERAVANCE BIOPHARMA R&D IP, LLC

US Patent


Assay Description
A panel of four LanthaScreen JAK biochemical assays (JAK1, 2, 3 and Tyk2) were carried in a common kinase reaction buffer (50 mM HEPES, pH 7.5, 0.01%...


US Patent US10485803 (2019)

More data for this
Ligand-Target Pair
JAK1/TYK2


(Homo sapiens (Human))
BDBM279824
PNG
(US10028960, Example 1-7 | US10485803, Example 1-7)
Show SMILES COc1cc(Nc2cc(CO)[nH]n2)nc(N[C@H]2C[C@@H]3CCC[C@H](C2)N3S(=O)(=O)c2cncc(F)c2)n1
Show InChI InChI=1/C22H27FN8O4S/c1-35-21-9-19(26-20-8-15(12-32)29-30-20)27-22(28-21)25-14-6-16-3-2-4-17(7-14)31(16)36(33,34)18-5-13(23)10-24-11-18/h5,8-11,14,16-17,32H,2-4,6-7,12H2,1H3,(H3,25,26,27,28,29,30)/t14-,16-,17+
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THERAVANCE BIOPHARMA R&D IP, LLC

US Patent


Assay Description
A panel of four LanthaScreen JAK biochemical assays (JAK1, 2, 3 and Tyk2) were carried in a common kinase reaction buffer (50 mM HEPES, pH 7.5, 0.01%...


US Patent US10485803 (2019)

More data for this
Ligand-Target Pair
JAK1/TYK2


(Homo sapiens (Human))
BDBM279826
PNG
(US10028960, Example 1-9 | US10485803, Example 1-9)
Show SMILES CCS(=O)(=O)N1[C@H]2CCC[C@@H]1C[C@H](C2)Nc1nc(Nc2cc(CO)[nH]n2)cc(OC)n1
Show InChI InChI=1/C19H29N7O4S/c1-3-31(28,29)26-14-5-4-6-15(26)8-12(7-14)20-19-22-16(10-18(23-19)30-2)21-17-9-13(11-27)24-25-17/h9-10,12,14-15,27H,3-8,11H2,1-2H3,(H3,20,21,22,23,24,25)/t12-,14-,15+
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0.550n/an/an/an/an/an/an/an/a



THERAVANCE BIOPHARMA R&D IP, LLC

US Patent


Assay Description
A panel of four LanthaScreen JAK biochemical assays (JAK1, 2, 3 and Tyk2) were carried in a common kinase reaction buffer (50 mM HEPES, pH 7.5, 0.01%...


US Patent US10485803 (2019)

More data for this
Ligand-Target Pair
JAK2/TYK2


(Homo sapiens (Human))
BDBM279829
PNG
(US10028960, Example 1-12 | US10485803, Example 1-1...)
Show SMILES COc1cc(Nc2cc(CO)[nH]n2)nc(n1)N(C)[C@H]1C[C@@H]2CCC[C@H](C1)N2S(=O)(=O)CCC#N
Show InChI InChI=1/C21H30N8O4S/c1-28(17-10-15-5-3-6-16(11-17)29(15)34(31,32)8-4-7-22)21-24-18(12-20(25-21)33-2)23-19-9-14(13-30)26-27-19/h9,12,15-17,30H,3-6,8,10-11,13H2,1-2H3,(H2,23,24,25,26,27)/t15-,16+,17-
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0.550n/an/an/an/an/an/an/an/a



THERAVANCE BIOPHARMA R&D IP, LLC

US Patent


Assay Description
A panel of four LanthaScreen JAK biochemical assays (JAK1, 2, 3 and Tyk2) were carried in a common kinase reaction buffer (50 mM HEPES, pH 7.5, 0.01%...


US Patent US10485803 (2019)

More data for this
Ligand-Target Pair
JAK1/TYK2


(Homo sapiens (Human))
BDBM279833
PNG
(US10028960, Example 1-16 | US10485803, Example 1-1...)
Show SMILES COc1cc(Nc2cc(CO)[nH]n2)nc(n1)N(C)[C@H]1C[C@@H]2CCC[C@H](C1)N2S(=O)(=O)c1ccccc1
Show InChI InChI=1/C24H31N7O4S/c1-30(24-26-21(14-23(27-24)35-2)25-22-11-16(15-32)28-29-22)19-12-17-7-6-8-18(13-19)31(17)36(33,34)20-9-4-3-5-10-20/h3-5,9-11,14,17-19,32H,6-8,12-13,15H2,1-2H3,(H2,25,26,27,28,29)/t17-,18+,19-
PDB

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0.550n/an/an/an/an/an/an/an/a



THERAVANCE BIOPHARMA R&D IP, LLC

US Patent


Assay Description
A panel of four LanthaScreen JAK biochemical assays (JAK1, 2, 3 and Tyk2) were carried in a common kinase reaction buffer (50 mM HEPES, pH 7.5, 0.01%...


US Patent US10485803 (2019)

More data for this
Ligand-Target Pair
JAK1/TYK2


(Homo sapiens (Human))
BDBM279836
PNG
(US10028960, Example 1-19 | US10485803, Example 1-1...)
Show SMILES COc1cc(Nc2cc(CO)[nH]n2)nc(n1)N(C)[C@H]1C[C@@H]2CCC[C@H](C1)N2S(=O)(=O)c1cncc(F)c1
Show InChI InChI=1/C23H29FN8O4S/c1-31(23-27-20(10-22(28-23)36-2)26-21-7-15(13-33)29-30-21)18-8-16-4-3-5-17(9-18)32(16)37(34,35)19-6-14(24)11-25-12-19/h6-7,10-12,16-18,33H,3-5,8-9,13H2,1-2H3,(H2,26,27,28,29,30)/t16-,17+,18-
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0.550n/an/an/an/an/an/an/an/a



THERAVANCE BIOPHARMA R&D IP, LLC

US Patent


Assay Description
A panel of four LanthaScreen JAK biochemical assays (JAK1, 2, 3 and Tyk2) were carried in a common kinase reaction buffer (50 mM HEPES, pH 7.5, 0.01%...


US Patent US10485803 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM279841
PNG
(US10028960, Example 2-5 | US10485803, Example 2-5)
Show SMILES COc1cc(Nc2cc(CO)[nH]n2)nc(n1)N(C)[C@H]1C[C@@H]2CCC[C@H](C1)N2CCC#N
Show InChI InChI=1/C21H30N8O2/c1-28(17-10-15-5-3-6-16(11-17)29(15)8-4-7-22)21-24-18(12-20(25-21)31-2)23-19-9-14(13-30)26-27-19/h9,12,15-17,30H,3-6,8,10-11,13H2,1-2H3,(H2,23,24,25,26,27)/t15-,16+,17-
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0.550n/an/an/an/an/an/an/an/a



THERAVANCE BIOPHARMA R&D IP, LLC

US Patent


Assay Description
A panel of four LanthaScreen JAK biochemical assays (JAK1, 2, 3 and Tyk2) were carried in a common kinase reaction buffer (50 mM HEPES, pH 7.5, 0.01%...


US Patent US10485803 (2019)

More data for this
Ligand-Target Pair
JAK2/TYK2


(Homo sapiens (Human))
BDBM420063
PNG
(US10485803, Example 2-6)
Show SMILES COc1cc(Nc2cc(CO)[nH]n2)nc(n1)N(C)[C@H]1C[C@@H]2CCC[C@H](C1)N2CC1CC1C#N
Show InChI InChI=1/C23H32N8O2/c1-30(19-8-17-4-3-5-18(9-19)31(17)12-15-6-14(15)11-24)23-26-20(10-22(27-23)33-2)25-21-7-16(13-32)28-29-21/h7,10,14-15,17-19,32H,3-6,8-9,12-13H2,1-2H3,(H2,25,26,27,28,29)/t14?,15?,17-,18+,19-
PDB

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THERAVANCE BIOPHARMA R&D IP, LLC

US Patent


Assay Description
A panel of four LanthaScreen JAK biochemical assays (JAK1, 2, 3 and Tyk2) were carried in a common kinase reaction buffer (50 mM HEPES, pH 7.5, 0.01%...


US Patent US10485803 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM279849
PNG
(US10028960, Example 3-4 | US10485803, Example 3-4)
Show SMILES COc1cc(Nc2cc(CO)[nH]n2)nc(n1)N(C)[C@H]1C[C@@H]2CCC[C@H](C1)N2C(=O)N1CCOCC1
Show InChI InChI=1/C23H34N8O4/c1-29(22-25-19(13-21(26-22)34-2)24-20-10-15(14-32)27-28-20)18-11-16-4-3-5-17(12-18)31(16)23(33)30-6-8-35-9-7-30/h10,13,16-18,32H,3-9,11-12,14H2,1-2H3,(H2,24,25,26,27,28)/t16-,17+,18-
PDB

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THERAVANCE BIOPHARMA R&D IP, LLC

US Patent


Assay Description
A panel of four LanthaScreen JAK biochemical assays (JAK1, 2, 3 and Tyk2) were carried in a common kinase reaction buffer (50 mM HEPES, pH 7.5, 0.01%...


US Patent US10485803 (2019)

More data for this
Ligand-Target Pair
JAK1/TYK2


(Homo sapiens (Human))
BDBM420072
PNG
(US10485803, Example 3-6)
Show SMILES COc1cc(Nc2cc(CO)[nH]n2)nc(n1)N(C)[C@H]1C[C@@H]2CCC[C@H](C1)N2C
Show InChI InChI=1/C19H29N7O2/c1-25-13-5-4-6-14(25)9-15(8-13)26(2)19-21-16(10-18(22-19)28-3)20-17-7-12(11-27)23-24-17/h7,10,13-15,27H,4-6,8-9,11H2,1-3H3,(H2,20,21,22,23,24)/t13-,14+,15-
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THERAVANCE BIOPHARMA R&D IP, LLC

US Patent


Assay Description
A panel of four LanthaScreen JAK biochemical assays (JAK1, 2, 3 and Tyk2) were carried in a common kinase reaction buffer (50 mM HEPES, pH 7.5, 0.01%...


US Patent US10485803 (2019)

More data for this
Ligand-Target Pair
JAK2/TYK2


(Homo sapiens (Human))
BDBM420074
PNG
(US10485803, Example 3-8)
Show SMILES COc1cc(Nc2cc(CO)[nH]n2)nc(n1)N(C)[C@H]1C[C@@H]2CCC[C@H](C1)N2C1CCC1
Show InChI InChI=1/C22H33N7O2/c1-28(18-10-16-7-4-8-17(11-18)29(16)15-5-3-6-15)22-24-19(12-21(25-22)31-2)23-20-9-14(13-30)26-27-20/h9,12,15-18,30H,3-8,10-11,13H2,1-2H3,(H2,23,24,25,26,27)/t16-,17+,18-
PDB

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THERAVANCE BIOPHARMA R&D IP, LLC

US Patent


Assay Description
A panel of four LanthaScreen JAK biochemical assays (JAK1, 2, 3 and Tyk2) were carried in a common kinase reaction buffer (50 mM HEPES, pH 7.5, 0.01%...


US Patent US10485803 (2019)

More data for this
Ligand-Target Pair
JAK2/TYK2


(Homo sapiens (Human))
BDBM279810
PNG
(1-(((1R,3s,5S)-3-((4-((5-(Hydroxymethyl)-1H-pyrazo...)
Show SMILES COc1cc(Nc2cc(CO)[nH]n2)nc(n1)N(C)[C@H]1C[C@@H]2CCC[C@H](C1)N2S(=O)(=O)N1CC(C1)C#N
Show InChI InChI=1/C22H31N9O4S/c1-29(22-25-19(9-21(26-22)35-2)24-20-6-15(13-32)27-28-20)18-7-16-4-3-5-17(8-18)31(16)36(33,34)30-11-14(10-23)12-30/h6,9,14,16-18,32H,3-5,7-8,11-13H2,1-2H3,(H2,24,25,26,27,28)/t16-,17+,18-
PDB

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0.550n/an/an/an/an/an/an/an/a



THERAVANCE BIOPHARMA R&D IP, LLC

US Patent


Assay Description
A panel of four LanthaScreen JAK biochemical assays (JAK1, 2, 3 and Tyk2) were carried in a common kinase reaction buffer (50 mM HEPES, pH 7.5, 0.01%...


US Patent US10485803 (2019)

More data for this
Ligand-Target Pair
JAK1/TYK2


(Homo sapiens (Human))
BDBM279812
PNG
((3-((6-methoxy-2-(((1R,3s,5S)-9-((2-methoxyethyl)s...)
Show SMILES COCCS(=O)(=O)N1[C@H]2CCC[C@@H]1C[C@H](C2)N(C)c1nc(Nc2cc(CO)[nH]n2)cc(OC)n1
Show InChI InChI=1/C21H33N7O5S/c1-27(17-10-15-5-4-6-16(11-17)28(15)34(30,31)8-7-32-2)21-23-18(12-20(24-21)33-3)22-19-9-14(13-29)25-26-19/h9,12,15-17,29H,4-8,10-11,13H2,1-3H3,(H2,22,23,24,25,26)/t15-,16+,17-
PDB

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0.550n/an/an/an/an/an/an/an/a



THERAVANCE BIOPHARMA R&D IP, LLC

US Patent


Assay Description
A panel of four LanthaScreen JAK biochemical assays (JAK1, 2, 3 and Tyk2) were carried in a common kinase reaction buffer (50 mM HEPES, pH 7.5, 0.01%...


US Patent US10485803 (2019)

More data for this
Ligand-Target Pair
JAK1/TYK2


(Homo sapiens (Human))
BDBM279834
PNG
(US10028960, Example 1-17 | US10485803, Example 1-1...)
Show SMILES COc1cc(Nc2cc(CO)[nH]n2)nc(n1)N(C)[C@H]1C[C@@H]2CCC[C@H](C1)N2S(=O)(=O)N1CCC1
Show InChI InChI=1/C21H32N8O4S/c1-27(21-23-18(12-20(24-21)33-2)22-19-9-14(13-30)25-26-19)17-10-15-5-3-6-16(11-17)29(15)34(31,32)28-7-4-8-28/h9,12,15-17,30H,3-8,10-11,13H2,1-2H3,(H2,22,23,24,25,26)/t15-,16+,17-
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0.550n/an/an/an/an/an/an/an/a



THERAVANCE BIOPHARMA R&D IP, LLC

US Patent


Assay Description
A panel of four LanthaScreen JAK biochemical assays (JAK1, 2, 3 and Tyk2) were carried in a common kinase reaction buffer (50 mM HEPES, pH 7.5, 0.01%...


US Patent US10485803 (2019)

More data for this
Ligand-Target Pair
JAK1/TYK2


(Homo sapiens (Human))
BDBM279843
PNG
(US10028960, Example 2-7 | US10485803, Example 2-7)
Show SMILES COc1cc(Nc2cc(CO)[nH]n2)nc(n1)N(C)[C@H]1C[C@@H]2CCC[C@H](C1)N2Cc1ccncc1
Show InChI InChI=1/C24H32N8O2/c1-31(24-27-21(13-23(28-24)34-2)26-22-10-17(15-33)29-30-22)20-11-18-4-3-5-19(12-20)32(18)14-16-6-8-25-9-7-16/h6-10,13,18-20,33H,3-5,11-12,14-15H2,1-2H3,(H2,26,27,28,29,30)/t18-,19+,20-
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0.550n/an/an/an/an/an/an/an/a



THERAVANCE BIOPHARMA R&D IP, LLC

US Patent


Assay Description
A panel of four LanthaScreen JAK biochemical assays (JAK1, 2, 3 and Tyk2) were carried in a common kinase reaction buffer (50 mM HEPES, pH 7.5, 0.01%...


US Patent US10485803 (2019)

More data for this
Ligand-Target Pair
JAK2/TYK2


(Homo sapiens (Human))
BDBM279810
PNG
(1-(((1R,3s,5S)-3-((4-((5-(Hydroxymethyl)-1H-pyrazo...)
Show SMILES COc1cc(Nc2cc(CO)[nH]n2)nc(n1)N(C)[C@H]1C[C@@H]2CCC[C@H](C1)N2S(=O)(=O)N1CC(C1)C#N
Show InChI InChI=1/C22H31N9O4S/c1-29(22-25-19(9-21(26-22)35-2)24-20-6-15(13-32)27-28-20)18-7-16-4-3-5-17(8-18)31(16)36(33,34)30-11-14(10-23)12-30/h6,9,14,16-18,32H,3-5,7-8,11-13H2,1-2H3,(H2,24,25,26,27,28)/t16-,17+,18-
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0.550n/an/an/an/an/an/an/an/a



THERAVANCE BIOPHARMA R&D IP, LLC

US Patent


Assay Description
A panel of four LanthaScreen JAK biochemical assays (JAK1, 2, 3 and Tyk2) were carried in a common kinase reaction buffer (50 mM HEPES, pH 7.5, 0.01%...


US Patent US10485803 (2019)

More data for this
Ligand-Target Pair
JAK1/TYK2


(Homo sapiens (Human))
BDBM279813
PNG
(3-((1R,3s,5S)-3-((4-((5-(hydroxymethyl)-1H-pyrazol...)
Show SMILES COc1cc(Nc2cc(CO)[nH]n2)nc(n1)N(C)[C@H]1C[C@@H]2CC[C@H](C1)N2CCC#N
Show InChI InChI=1/C20H28N8O2/c1-27(16-9-14-4-5-15(10-16)28(14)7-3-6-21)20-23-17(11-19(24-20)30-2)22-18-8-13(12-29)25-26-18/h8,11,14-16,29H,3-5,7,9-10,12H2,1-2H3,(H2,22,23,24,25,26)/t14-,15+,16-
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0.550n/an/an/an/an/an/an/an/a



THERAVANCE BIOPHARMA R&D IP, LLC

US Patent


Assay Description
A panel of four LanthaScreen JAK biochemical assays (JAK1, 2, 3 and Tyk2) were carried in a common kinase reaction buffer (50 mM HEPES, pH 7.5, 0.01%...


US Patent US10485803 (2019)

More data for this
Ligand-Target Pair
JAK2/TYK2


(Homo sapiens (Human))
BDBM279816
PNG
(Isobutyl (1R,3s,5S)-3-((4-((5-(hydroxymethyl)-1H-p...)
Show SMILES COc1cc(Nc2cc(CO)[nH]n2)nc(n1)N(C)[C@H]1C[C@@H]2CCC[C@H](C1)N2C(=O)OCC(C)C
Show InChI InChI=1/C23H35N7O4/c1-14(2)13-34-23(32)30-16-6-5-7-17(30)10-18(9-16)29(3)22-25-19(11-21(26-22)33-4)24-20-8-15(12-31)27-28-20/h8,11,14,16-18,31H,5-7,9-10,12-13H2,1-4H3,(H2,24,25,26,27,28)/t16-,17+,18-
PDB

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0.550n/an/an/an/an/an/an/an/a



THERAVANCE BIOPHARMA R&D IP, LLC

US Patent


Assay Description
A panel of four LanthaScreen JAK biochemical assays (JAK1, 2, 3 and Tyk2) were carried in a common kinase reaction buffer (50 mM HEPES, pH 7.5, 0.01%...


US Patent US10485803 (2019)

More data for this
Ligand-Target Pair
JAK2/TYK2


(Homo sapiens (Human))
BDBM420035
PNG
(US10485803, Example 9)
Show SMILES COc1cc(Nc2cc(CO)[nH]n2)nc(n1)N(C)[C@H]1C[C@@H]2CCC[C@H](C1)N2C(=O)C(F)F
Show InChI InChI=1/C20H27F2N7O3/c1-28(14-7-12-4-3-5-13(8-14)29(12)19(31)18(21)22)20-24-15(9-17(25-20)32-2)23-16-6-11(10-30)26-27-16/h6,9,12-14,18,30H,3-5,7-8,10H2,1-2H3,(H2,23,24,25,26,27)/t12-,13+,14-
PDB

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THERAVANCE BIOPHARMA R&D IP, LLC

US Patent


Assay Description
A panel of four LanthaScreen JAK biochemical assays (JAK1, 2, 3 and Tyk2) were carried in a common kinase reaction buffer (50 mM HEPES, pH 7.5, 0.01%...


US Patent US10485803 (2019)

More data for this
Ligand-Target Pair
JAK2/TYK2


(Homo sapiens (Human))
BDBM279833
PNG
(US10028960, Example 1-16 | US10485803, Example 1-1...)
Show SMILES COc1cc(Nc2cc(CO)[nH]n2)nc(n1)N(C)[C@H]1C[C@@H]2CCC[C@H](C1)N2S(=O)(=O)c1ccccc1
Show InChI InChI=1/C24H31N7O4S/c1-30(24-26-21(14-23(27-24)35-2)25-22-11-16(15-32)28-29-22)19-12-17-7-6-8-18(13-19)31(17)36(33,34)20-9-4-3-5-10-20/h3-5,9-11,14,17-19,32H,6-8,12-13,15H2,1-2H3,(H2,25,26,27,28,29)/t17-,18+,19-
PDB

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0.550n/an/an/an/an/an/an/an/a



THERAVANCE BIOPHARMA R&D IP, LLC

US Patent


Assay Description
A panel of four LanthaScreen JAK biochemical assays (JAK1, 2, 3 and Tyk2) were carried in a common kinase reaction buffer (50 mM HEPES, pH 7.5, 0.01%...


US Patent US10485803 (2019)

More data for this
Ligand-Target Pair
JAK1/TYK2


(Homo sapiens (Human))
BDBM279846
PNG
(US10028960, Example 3-1 | US10485803, Example 3-1)
Show SMILES COc1cc(Nc2cc(CO)[nH]n2)nc(N[C@H]2C[C@@H]3CCC[C@H](C2)N3C(=O)C(F)F)n1
Show InChI InChI=1/C19H25F2N7O3/c1-31-16-8-14(23-15-7-11(9-29)26-27-15)24-19(25-16)22-10-5-12-3-2-4-13(6-10)28(12)18(30)17(20)21/h7-8,10,12-13,17,29H,2-6,9H2,1H3,(H3,22,23,24,25,26,27)/t10-,12-,13+
PDB

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0.550n/an/an/an/an/an/an/an/a



THERAVANCE BIOPHARMA R&D IP, LLC

US Patent


Assay Description
A panel of four LanthaScreen JAK biochemical assays (JAK1, 2, 3 and Tyk2) were carried in a common kinase reaction buffer (50 mM HEPES, pH 7.5, 0.01%...


US Patent US10485803 (2019)

More data for this
Ligand-Target Pair
JAK2/TYK2


(Homo sapiens (Human))
BDBM420068
PNG
(US10485803, Example 3-2)
Show SMILES CCC(C)OC(=O)N1[C@H]2CCC[C@@H]1C[C@H](C2)N(C)c1nc(Nc2cc(CO)[nH]n2)cc(OC)n1
Show InChI InChI=1/C23H35N7O4/c1-5-14(2)34-23(32)30-16-7-6-8-17(30)11-18(10-16)29(3)22-25-19(12-21(26-22)33-4)24-20-9-15(13-31)27-28-20/h9,12,14,16-18,31H,5-8,10-11,13H2,1-4H3,(H2,24,25,26,27,28)/t14?,16-,17+,18-
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THERAVANCE BIOPHARMA R&D IP, LLC

US Patent


Assay Description
A panel of four LanthaScreen JAK biochemical assays (JAK1, 2, 3 and Tyk2) were carried in a common kinase reaction buffer (50 mM HEPES, pH 7.5, 0.01%...


US Patent US10485803 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM279848
PNG
(US10028960, Example 3-3 | US10485803, Example 3-3)
Show SMILES COC(=O)N1[C@H]2CCC[C@@H]1C[C@H](C2)N(C)c1nc(Nc2cc(CO)[nH]n2)cc(OC)n1
Show InChI InChI=1/C20H29N7O4/c1-26(15-8-13-5-4-6-14(9-15)27(13)20(29)31-3)19-22-16(10-18(23-19)30-2)21-17-7-12(11-28)24-25-17/h7,10,13-15,28H,4-6,8-9,11H2,1-3H3,(H2,21,22,23,24,25)/t13-,14+,15-
PDB

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0.550n/an/an/an/an/an/an/an/a



THERAVANCE BIOPHARMA R&D IP, LLC

US Patent


Assay Description
A panel of four LanthaScreen JAK biochemical assays (JAK1, 2, 3 and Tyk2) were carried in a common kinase reaction buffer (50 mM HEPES, pH 7.5, 0.01%...


US Patent US10485803 (2019)

More data for this
Ligand-Target Pair
JAK1/TYK2


(Homo sapiens (Human))
BDBM279849
PNG
(US10028960, Example 3-4 | US10485803, Example 3-4)
Show SMILES COc1cc(Nc2cc(CO)[nH]n2)nc(n1)N(C)[C@H]1C[C@@H]2CCC[C@H](C1)N2C(=O)N1CCOCC1
Show InChI InChI=1/C23H34N8O4/c1-29(22-25-19(13-21(26-22)34-2)24-20-10-15(14-32)27-28-20)18-11-16-4-3-5-17(12-18)31(16)23(33)30-6-8-35-9-7-30/h10,13,16-18,32H,3-9,11-12,14H2,1-2H3,(H2,24,25,26,27,28)/t16-,17+,18-
PDB

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0.550n/an/an/an/an/an/an/an/a



THERAVANCE BIOPHARMA R&D IP, LLC

US Patent


Assay Description
A panel of four LanthaScreen JAK biochemical assays (JAK1, 2, 3 and Tyk2) were carried in a common kinase reaction buffer (50 mM HEPES, pH 7.5, 0.01%...


US Patent US10485803 (2019)

More data for this
Ligand-Target Pair
JAK2/TYK2


(Homo sapiens (Human))
BDBM420071
PNG
(US10485803, Example 3-5)
Show SMILES COc1cc(Nc2cc(CO)[nH]n2)nc(n1)N(C)[C@H]1C[C@@H]2CCC[C@H](C1)N2C(=O)C1CC1
Show InChI InChI=1/C22H31N7O3/c1-28(17-9-15-4-3-5-16(10-17)29(15)21(31)13-6-7-13)22-24-18(11-20(25-22)32-2)23-19-8-14(12-30)26-27-19/h8,11,13,15-17,30H,3-7,9-10,12H2,1-2H3,(H2,23,24,25,26,27)/t15-,16+,17-
PDB

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THERAVANCE BIOPHARMA R&D IP, LLC

US Patent


Assay Description
A panel of four LanthaScreen JAK biochemical assays (JAK1, 2, 3 and Tyk2) were carried in a common kinase reaction buffer (50 mM HEPES, pH 7.5, 0.01%...


US Patent US10485803 (2019)

More data for this
Ligand-Target Pair
JAK1/TYK2


(Homo sapiens (Human))
BDBM420036
PNG
(US10485803, Example 1-1)
Show SMILES COc1cc(Nc2cc(CO)[nH]n2)nc(N[C@H]2C[C@@H]3CC[C@H](C2)N3S(=O)(=O)N2CCC2)n1
Show InChI InChI=1/C19H28N8O4S/c1-31-18-10-16(21-17-9-13(11-28)24-25-17)22-19(23-18)20-12-7-14-3-4-15(8-12)27(14)32(29,30)26-5-2-6-26/h9-10,12,14-15,28H,2-8,11H2,1H3,(H3,20,21,22,23,24,25)/t12-,14-,15+
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THERAVANCE BIOPHARMA R&D IP, LLC

US Patent


Assay Description
A panel of four LanthaScreen JAK biochemical assays (JAK1, 2, 3 and Tyk2) were carried in a common kinase reaction buffer (50 mM HEPES, pH 7.5, 0.01%...


US Patent US10485803 (2019)

More data for this
Ligand-Target Pair
JAK3/JAK1


(Homo sapiens (Human))
BDBM420063
PNG
(US10485803, Example 2-6)
Show SMILES COc1cc(Nc2cc(CO)[nH]n2)nc(n1)N(C)[C@H]1C[C@@H]2CCC[C@H](C1)N2CC1CC1C#N
Show InChI InChI=1/C23H32N8O2/c1-30(19-8-17-4-3-5-18(9-19)31(17)12-15-6-14(15)11-24)23-26-20(10-22(27-23)33-2)25-21-7-16(13-32)28-29-21/h7,10,14-15,17-19,32H,3-6,8-9,12-13H2,1-2H3,(H2,25,26,27,28,29)/t14?,15?,17-,18+,19-
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THERAVANCE BIOPHARMA R&D IP, LLC

US Patent


Assay Description
A panel of four LanthaScreen JAK biochemical assays (JAK1, 2, 3 and Tyk2) were carried in a common kinase reaction buffer (50 mM HEPES, pH 7.5, 0.01%...


US Patent US10485803 (2019)

More data for this
Ligand-Target Pair
JAK2/TYK2


(Homo sapiens (Human))
BDBM420072
PNG
(US10485803, Example 3-6)
Show SMILES COc1cc(Nc2cc(CO)[nH]n2)nc(n1)N(C)[C@H]1C[C@@H]2CCC[C@H](C1)N2C
Show InChI InChI=1/C19H29N7O2/c1-25-13-5-4-6-14(25)9-15(8-13)26(2)19-21-16(10-18(22-19)28-3)20-17-7-12(11-27)23-24-17/h7,10,13-15,27H,4-6,8-9,11H2,1-3H3,(H2,20,21,22,23,24)/t13-,14+,15-
PDB

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THERAVANCE BIOPHARMA R&D IP, LLC

US Patent


Assay Description
A panel of four LanthaScreen JAK biochemical assays (JAK1, 2, 3 and Tyk2) were carried in a common kinase reaction buffer (50 mM HEPES, pH 7.5, 0.01%...


US Patent US10485803 (2019)

More data for this
Ligand-Target Pair
JAK2/TYK2


(Homo sapiens (Human))
BDBM279848
PNG
(US10028960, Example 3-3 | US10485803, Example 3-3)
Show SMILES COC(=O)N1[C@H]2CCC[C@@H]1C[C@H](C2)N(C)c1nc(Nc2cc(CO)[nH]n2)cc(OC)n1
Show InChI InChI=1/C20H29N7O4/c1-26(15-8-13-5-4-6-14(9-15)27(13)20(29)31-3)19-22-16(10-18(23-19)30-2)21-17-7-12(11-28)24-25-17/h7,10,13-15,28H,4-6,8-9,11H2,1-3H3,(H2,21,22,23,24,25)/t13-,14+,15-
PDB

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THERAVANCE BIOPHARMA R&D IP, LLC

US Patent


Assay Description
A panel of four LanthaScreen JAK biochemical assays (JAK1, 2, 3 and Tyk2) were carried in a common kinase reaction buffer (50 mM HEPES, pH 7.5, 0.01%...


US Patent US10485803 (2019)

More data for this
Ligand-Target Pair
JAK2/TYK2


(Homo sapiens (Human))
BDBM279841
PNG
(US10028960, Example 2-5 | US10485803, Example 2-5)
Show SMILES COc1cc(Nc2cc(CO)[nH]n2)nc(n1)N(C)[C@H]1C[C@@H]2CCC[C@H](C1)N2CCC#N
Show InChI InChI=1/C21H30N8O2/c1-28(17-10-15-5-3-6-16(11-17)29(15)8-4-7-22)21-24-18(12-20(25-21)31-2)23-19-9-14(13-30)26-27-19/h9,12,15-17,30H,3-6,8,10-11,13H2,1-2H3,(H2,23,24,25,26,27)/t15-,16+,17-
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5.5n/an/an/an/an/an/an/an/a



THERAVANCE BIOPHARMA R&D IP, LLC

US Patent


Assay Description
A panel of four LanthaScreen JAK biochemical assays (JAK1, 2, 3 and Tyk2) were carried in a common kinase reaction buffer (50 mM HEPES, pH 7.5, 0.01%...


US Patent US10485803 (2019)

More data for this
Ligand-Target Pair
JAK1/TYK2


(Homo sapiens (Human))
BDBM279837
PNG
(US10028960, Example 2-1 | US10485803, Example 2-1)
Show SMILES COc1cc(Nc2cc(CO)[nH]n2)nc(N[C@H]2C[C@@H]3CC[C@H](C2)N3Cc2ccncc2)n1
Show InChI InChI=1/C22H28N8O2/c1-32-21-11-19(25-20-10-16(13-31)28-29-20)26-22(27-21)24-15-8-17-2-3-18(9-15)30(17)12-14-4-6-23-7-5-14/h4-7,10-11,15,17-18,31H,2-3,8-9,12-13H2,1H3,(H3,24,25,26,27,28,29)/t15-,17-,18+
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5.5n/an/an/an/an/an/an/an/a



THERAVANCE BIOPHARMA R&D IP, LLC

US Patent


Assay Description
A panel of four LanthaScreen JAK biochemical assays (JAK1, 2, 3 and Tyk2) were carried in a common kinase reaction buffer (50 mM HEPES, pH 7.5, 0.01%...


US Patent US10485803 (2019)

More data for this
Ligand-Target Pair
JAK3/JAK1


(Homo sapiens (Human))
BDBM279833
PNG
(US10028960, Example 1-16 | US10485803, Example 1-1...)
Show SMILES COc1cc(Nc2cc(CO)[nH]n2)nc(n1)N(C)[C@H]1C[C@@H]2CCC[C@H](C1)N2S(=O)(=O)c1ccccc1
Show InChI InChI=1/C24H31N7O4S/c1-30(24-26-21(14-23(27-24)35-2)25-22-11-16(15-32)28-29-22)19-12-17-7-6-8-18(13-19)31(17)36(33,34)20-9-4-3-5-10-20/h3-5,9-11,14,17-19,32H,6-8,12-13,15H2,1-2H3,(H2,25,26,27,28,29)/t17-,18+,19-
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5.5n/an/an/an/an/an/an/an/a



THERAVANCE BIOPHARMA R&D IP, LLC

US Patent


Assay Description
A panel of four LanthaScreen JAK biochemical assays (JAK1, 2, 3 and Tyk2) were carried in a common kinase reaction buffer (50 mM HEPES, pH 7.5, 0.01%...


US Patent US10485803 (2019)

More data for this
Ligand-Target Pair
JAK3/JAK1


(Homo sapiens (Human))
BDBM279832
PNG
(US10028960, Example 1-15 | US10485803, Example 1-1...)
Show SMILES COc1cc(Nc2cc(CO)[nH]n2)nc(n1)N(C)[C@H]1C[C@@H]2CCC[C@H](C1)N2S(=O)(=O)c1cccnc1
Show InChI InChI=1/C23H30N8O4S/c1-30(23-26-20(12-22(27-23)35-2)25-21-9-15(14-32)28-29-21)18-10-16-5-3-6-17(11-18)31(16)36(33,34)19-7-4-8-24-13-19/h4,7-9,12-13,16-18,32H,3,5-6,10-11,14H2,1-2H3,(H2,25,26,27,28,29)/t16-,17+,18-
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5.5n/an/an/an/an/an/an/an/a



THERAVANCE BIOPHARMA R&D IP, LLC

US Patent


Assay Description
A panel of four LanthaScreen JAK biochemical assays (JAK1, 2, 3 and Tyk2) were carried in a common kinase reaction buffer (50 mM HEPES, pH 7.5, 0.01%...


US Patent US10485803 (2019)

More data for this
Ligand-Target Pair
JAK3/JAK1


(Homo sapiens (Human))
BDBM279810
PNG
(1-(((1R,3s,5S)-3-((4-((5-(Hydroxymethyl)-1H-pyrazo...)
Show SMILES COc1cc(Nc2cc(CO)[nH]n2)nc(n1)N(C)[C@H]1C[C@@H]2CCC[C@H](C1)N2S(=O)(=O)N1CC(C1)C#N
Show InChI InChI=1/C22H31N9O4S/c1-29(22-25-19(9-21(26-22)35-2)24-20-6-15(13-32)27-28-20)18-7-16-4-3-5-17(8-18)31(16)36(33,34)30-11-14(10-23)12-30/h6,9,14,16-18,32H,3-5,7-8,11-13H2,1-2H3,(H2,24,25,26,27,28)/t16-,17+,18-
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THERAVANCE BIOPHARMA R&D IP, LLC

US Patent


Assay Description
A panel of four LanthaScreen JAK biochemical assays (JAK1, 2, 3 and Tyk2) were carried in a common kinase reaction buffer (50 mM HEPES, pH 7.5, 0.01%...


US Patent US10485803 (2019)

More data for this
Ligand-Target Pair
JAK3/JAK1


(Homo sapiens (Human))
BDBM279812
PNG
((3-((6-methoxy-2-(((1R,3s,5S)-9-((2-methoxyethyl)s...)
Show SMILES COCCS(=O)(=O)N1[C@H]2CCC[C@@H]1C[C@H](C2)N(C)c1nc(Nc2cc(CO)[nH]n2)cc(OC)n1
Show InChI InChI=1/C21H33N7O5S/c1-27(17-10-15-5-4-6-16(11-17)28(15)34(30,31)8-7-32-2)21-23-18(12-20(24-21)33-3)22-19-9-14(13-29)25-26-19/h9,12,15-17,29H,4-8,10-11,13H2,1-3H3,(H2,22,23,24,25,26)/t15-,16+,17-
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5.5n/an/an/an/an/an/an/an/a



THERAVANCE BIOPHARMA R&D IP, LLC

US Patent


Assay Description
A panel of four LanthaScreen JAK biochemical assays (JAK1, 2, 3 and Tyk2) were carried in a common kinase reaction buffer (50 mM HEPES, pH 7.5, 0.01%...


US Patent US10485803 (2019)

More data for this
Ligand-Target Pair
JAK1/TYK2


(Homo sapiens (Human))
BDBM279820
PNG
(US10028960, Example 1-3 | US10485803, Example 1-3)
Show SMILES COc1cc(Nc2cc(CO)[nH]n2)nc(N[C@H]2C[C@@H]3CC[C@H](C2)N3S(=O)(=O)c2cccnc2)n1
Show InChI InChI=1/C21H26N8O4S/c1-33-20-10-18(24-19-9-14(12-30)27-28-19)25-21(26-20)23-13-7-15-4-5-16(8-13)29(15)34(31,32)17-3-2-6-22-11-17/h2-3,6,9-11,13,15-16,30H,4-5,7-8,12H2,1H3,(H3,23,24,25,26,27,28)/t13-,15-,16+
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5.5n/an/an/an/an/an/an/an/a



THERAVANCE BIOPHARMA R&D IP, LLC

US Patent


Assay Description
A panel of four LanthaScreen JAK biochemical assays (JAK1, 2, 3 and Tyk2) were carried in a common kinase reaction buffer (50 mM HEPES, pH 7.5, 0.01%...


US Patent US10485803 (2019)

More data for this
Ligand-Target Pair
JAK3/JAK1


(Homo sapiens (Human))
BDBM279834
PNG
(US10028960, Example 1-17 | US10485803, Example 1-1...)
Show SMILES COc1cc(Nc2cc(CO)[nH]n2)nc(n1)N(C)[C@H]1C[C@@H]2CCC[C@H](C1)N2S(=O)(=O)N1CCC1
Show InChI InChI=1/C21H32N8O4S/c1-27(21-23-18(12-20(24-21)33-2)22-19-9-14(13-30)25-26-19)17-10-15-5-3-6-16(11-17)29(15)34(31,32)28-7-4-8-28/h9,12,15-17,30H,3-8,10-11,13H2,1-2H3,(H2,22,23,24,25,26)/t15-,16+,17-
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5.5n/an/an/an/an/an/an/an/a



THERAVANCE BIOPHARMA R&D IP, LLC

US Patent


Assay Description
A panel of four LanthaScreen JAK biochemical assays (JAK1, 2, 3 and Tyk2) were carried in a common kinase reaction buffer (50 mM HEPES, pH 7.5, 0.01%...


US Patent US10485803 (2019)

More data for this
Ligand-Target Pair
JAK3/JAK1


(Homo sapiens (Human))
BDBM279829
PNG
(US10028960, Example 1-12 | US10485803, Example 1-1...)
Show SMILES COc1cc(Nc2cc(CO)[nH]n2)nc(n1)N(C)[C@H]1C[C@@H]2CCC[C@H](C1)N2S(=O)(=O)CCC#N
Show InChI InChI=1/C21H30N8O4S/c1-28(17-10-15-5-3-6-16(11-17)29(15)34(31,32)8-4-7-22)21-24-18(12-20(25-21)33-2)23-19-9-14(13-30)26-27-19/h9,12,15-17,30H,3-6,8,10-11,13H2,1-2H3,(H2,23,24,25,26,27)/t15-,16+,17-
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5.5n/an/an/an/an/an/an/an/a



THERAVANCE BIOPHARMA R&D IP, LLC

US Patent


Assay Description
A panel of four LanthaScreen JAK biochemical assays (JAK1, 2, 3 and Tyk2) were carried in a common kinase reaction buffer (50 mM HEPES, pH 7.5, 0.01%...


US Patent US10485803 (2019)

More data for this
Ligand-Target Pair
JAK3/JAK1


(Homo sapiens (Human))
BDBM279831
PNG
(US10028960, Example 1-14 | US10485803, Example 1-1...)
Show SMILES COc1cc(Nc2cc(CO)[nH]n2)nc(n1)N(C)[C@H]1C[C@@H]2CCC[C@H](C1)N2S(=O)(=O)C1CC1
Show InChI InChI=1/C21H31N7O4S/c1-27(16-9-14-4-3-5-15(10-16)28(14)33(30,31)17-6-7-17)21-23-18(11-20(24-21)32-2)22-19-8-13(12-29)25-26-19/h8,11,14-17,29H,3-7,9-10,12H2,1-2H3,(H2,22,23,24,25,26)/t14-,15+,16-
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5.5n/an/an/an/an/an/an/an/a



THERAVANCE BIOPHARMA R&D IP, LLC

US Patent


Assay Description
A panel of four LanthaScreen JAK biochemical assays (JAK1, 2, 3 and Tyk2) were carried in a common kinase reaction buffer (50 mM HEPES, pH 7.5, 0.01%...


US Patent US10485803 (2019)

More data for this
Ligand-Target Pair
JAK3/JAK1


(Homo sapiens (Human))
BDBM279811
PNG
((3-((6-methoxy-2-(methyl((1R,3s,5S)-9-(methylsulfo...)
Show SMILES COc1cc(Nc2cc(CO)[nH]n2)nc(n1)N(C)[C@H]1C[C@@H]2CCC[C@H](C1)N2S(C)(=O)=O
Show InChI InChI=1/C19H29N7O4S/c1-25(15-8-13-5-4-6-14(9-15)26(13)31(3,28)29)19-21-16(10-18(22-19)30-2)20-17-7-12(11-27)23-24-17/h7,10,13-15,27H,4-6,8-9,11H2,1-3H3,(H2,20,21,22,23,24)/t13-,14+,15-
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5.5n/an/an/an/an/an/an/an/a



THERAVANCE BIOPHARMA R&D IP, LLC

US Patent


Assay Description
A panel of four LanthaScreen JAK biochemical assays (JAK1, 2, 3 and Tyk2) were carried in a common kinase reaction buffer (50 mM HEPES, pH 7.5, 0.01%...


US Patent US10485803 (2019)

More data for this
Ligand-Target Pair
JAK2/TYK2


(Homo sapiens (Human))
BDBM279813
PNG
(3-((1R,3s,5S)-3-((4-((5-(hydroxymethyl)-1H-pyrazol...)
Show SMILES COc1cc(Nc2cc(CO)[nH]n2)nc(n1)N(C)[C@H]1C[C@@H]2CC[C@H](C1)N2CCC#N
Show InChI InChI=1/C20H28N8O2/c1-27(16-9-14-4-5-15(10-16)28(14)7-3-6-21)20-23-17(11-19(24-20)30-2)22-18-8-13(12-29)25-26-18/h8,11,14-16,29H,3-5,7,9-10,12H2,1-2H3,(H2,22,23,24,25,26)/t14-,15+,16-
PDB

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5.5n/an/an/an/an/an/an/an/a



THERAVANCE BIOPHARMA R&D IP, LLC

US Patent


Assay Description
A panel of four LanthaScreen JAK biochemical assays (JAK1, 2, 3 and Tyk2) were carried in a common kinase reaction buffer (50 mM HEPES, pH 7.5, 0.01%...


US Patent US10485803 (2019)

More data for this
Ligand-Target Pair
JAK3/JAK1


(Homo sapiens (Human))
BDBM279816
PNG
(Isobutyl (1R,3s,5S)-3-((4-((5-(hydroxymethyl)-1H-p...)
Show SMILES COc1cc(Nc2cc(CO)[nH]n2)nc(n1)N(C)[C@H]1C[C@@H]2CCC[C@H](C1)N2C(=O)OCC(C)C
Show InChI InChI=1/C23H35N7O4/c1-14(2)13-34-23(32)30-16-6-5-7-17(30)10-18(9-16)29(3)22-25-19(11-21(26-22)33-4)24-20-8-15(12-31)27-28-20/h8,11,14,16-18,31H,5-7,9-10,12-13H2,1-4H3,(H2,24,25,26,27,28)/t16-,17+,18-
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5.5n/an/an/an/an/an/an/an/a



THERAVANCE BIOPHARMA R&D IP, LLC

US Patent


Assay Description
A panel of four LanthaScreen JAK biochemical assays (JAK1, 2, 3 and Tyk2) were carried in a common kinase reaction buffer (50 mM HEPES, pH 7.5, 0.01%...


US Patent US10485803 (2019)

More data for this
Ligand-Target Pair
JAK3/JAK1


(Homo sapiens (Human))
BDBM420035
PNG
(US10485803, Example 9)
Show SMILES COc1cc(Nc2cc(CO)[nH]n2)nc(n1)N(C)[C@H]1C[C@@H]2CCC[C@H](C1)N2C(=O)C(F)F
Show InChI InChI=1/C20H27F2N7O3/c1-28(14-7-12-4-3-5-13(8-14)29(12)19(31)18(21)22)20-24-15(9-17(25-20)32-2)23-16-6-11(10-30)26-27-16/h6,9,12-14,18,30H,3-5,7-8,10H2,1-2H3,(H2,23,24,25,26,27)/t12-,13+,14-
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66n/an/an/an/an/an/an/an/a



THERAVANCE BIOPHARMA R&D IP, LLC

US Patent


Assay Description
A panel of four LanthaScreen JAK biochemical assays (JAK1, 2, 3 and Tyk2) were carried in a common kinase reaction buffer (50 mM HEPES, pH 7.5, 0.01%...


US Patent US10485803 (2019)

More data for this
Ligand-Target Pair
JAK3/JAK1


(Homo sapiens (Human))
BDBM279841
PNG
(US10028960, Example 2-5 | US10485803, Example 2-5)
Show SMILES COc1cc(Nc2cc(CO)[nH]n2)nc(n1)N(C)[C@H]1C[C@@H]2CCC[C@H](C1)N2CCC#N
Show InChI InChI=1/C21H30N8O2/c1-28(17-10-15-5-3-6-16(11-17)29(15)8-4-7-22)21-24-18(12-20(25-21)31-2)23-19-9-14(13-30)26-27-19/h9,12,15-17,30H,3-6,8,10-11,13H2,1-2H3,(H2,23,24,25,26,27)/t15-,16+,17-
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66n/an/an/an/an/an/an/an/a



THERAVANCE BIOPHARMA R&D IP, LLC

US Patent


Assay Description
A panel of four LanthaScreen JAK biochemical assays (JAK1, 2, 3 and Tyk2) were carried in a common kinase reaction buffer (50 mM HEPES, pH 7.5, 0.01%...


US Patent US10485803 (2019)

More data for this
Ligand-Target Pair
JAK1/TYK2


(Homo sapiens (Human))
BDBM279821
PNG
(US10028960, Example 1-4 | US10485803, Example 1-4)
Show SMILES COc1cc(Nc2cc(CO)[nH]n2)nc(N[C@H]2C[C@@H]3CC[C@H](C2)N3S(=O)(=O)c2ccccc2)n1
Show InChI InChI=1/C22H27N7O4S/c1-33-21-12-19(24-20-11-15(13-30)27-28-20)25-22(26-21)23-14-9-16-7-8-17(10-14)29(16)34(31,32)18-5-3-2-4-6-18/h2-6,11-12,14,16-17,30H,7-10,13H2,1H3,(H3,23,24,25,26,27,28)/t14-,16-,17+
PDB

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66n/an/an/an/an/an/an/an/a



THERAVANCE BIOPHARMA R&D IP, LLC

US Patent


Assay Description
A panel of four LanthaScreen JAK biochemical assays (JAK1, 2, 3 and Tyk2) were carried in a common kinase reaction buffer (50 mM HEPES, pH 7.5, 0.01%...


US Patent US10485803 (2019)

More data for this
Ligand-Target Pair
JAK3/JAK1


(Homo sapiens (Human))
BDBM279813
PNG
(3-((1R,3s,5S)-3-((4-((5-(hydroxymethyl)-1H-pyrazol...)
Show SMILES COc1cc(Nc2cc(CO)[nH]n2)nc(n1)N(C)[C@H]1C[C@@H]2CC[C@H](C1)N2CCC#N
Show InChI InChI=1/C20H28N8O2/c1-27(16-9-14-4-5-15(10-16)28(14)7-3-6-21)20-23-17(11-19(24-20)30-2)22-18-8-13(12-29)25-26-18/h8,11,14-16,29H,3-5,7,9-10,12H2,1-2H3,(H2,22,23,24,25,26)/t14-,15+,16-
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66n/an/an/an/an/an/an/an/a



THERAVANCE BIOPHARMA R&D IP, LLC

US Patent


Assay Description
A panel of four LanthaScreen JAK biochemical assays (JAK1, 2, 3 and Tyk2) were carried in a common kinase reaction buffer (50 mM HEPES, pH 7.5, 0.01%...


US Patent US10485803 (2019)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%