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Patent code US10487087

Compile Data Set for Download or QSAR
Found 38 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Glucagon-like peptide 1 receptor


(Homo sapiens (Human))
BDBM420030
PNG
((R)-2-cyclopentyl-N-((1-isopropylpyrrolidin-2- yl)...)
Show SMILES CC(C)N1CCC[C@@H]1CNC(=O)c1cn(C2CCCC2)c(=O)c2c(C)c3ccccc3n12
Show InChI InChI=1S/C26H34N4O2/c1-17(2)28-14-8-11-20(28)15-27-25(31)23-16-29(19-9-4-5-10-19)26(32)24-18(3)21-12-6-7-13-22(21)30(23)24/h6-7,12-13,16-17,19-20H,4-5,8-11,14-15H2,1-3H3,(H,27,31)/t20-/m1/s1
PDB

UniProtKB/SwissProt

GoogleScholar
UniChem
US Patent
n/an/an/an/a>3.00E+4n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
To assess the effects of test compounds on GLP-1 or glucagon potency and efficacy, a high-throughput calcium mobilization assay was used essentially ...


US Patent US10487087 (2019)

More data for this
Ligand-Target Pair
Glucagon-like peptide 1 receptor


(Homo sapiens (Human))
BDBM420065
PNG
(2-cyclopentyl-N-((1-isopropylazetidin-2- yl)methyl...)
Show SMILES CC(C)N1CCC1CNC(=O)c1cn(C2CCCC2)c(=O)c2c(C)c3ccccc3n12
Show InChI InChI=1S/C25H32N4O2/c1-16(2)27-13-12-19(27)14-26-24(30)22-15-28(18-8-4-5-9-18)25(31)23-17(3)20-10-6-7-11-21(20)29(22)23/h6-7,10-11,15-16,18-19H,4-5,8-9,12-14H2,1-3H3,(H,26,30)
PDB

UniProtKB/SwissProt

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US Patent
n/an/an/an/a 1.20E+4n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
To assess the effects of test compounds on GLP-1 or glucagon potency and efficacy, a high-throughput calcium mobilization assay was used essentially ...


US Patent US10487087 (2019)

More data for this
Ligand-Target Pair
Glucagon-like peptide 1 receptor


(Homo sapiens (Human))
BDBM420047
PNG
((S)-10-bromo-2-cyclopentyl-N-((1- isopropylpyrroli...)
Show SMILES CC(C)N1CCC[C@H]1CNC(=O)c1cn(C2CCCC2)c(=O)c2c(Br)c3ccccc3n12
Show InChI InChI=1S/C25H31BrN4O2/c1-16(2)28-13-7-10-18(28)14-27-24(31)21-15-29(17-8-3-4-9-17)25(32)23-22(26)19-11-5-6-12-20(19)30(21)23/h5-6,11-12,15-18H,3-4,7-10,13-14H2,1-2H3,(H,27,31)/t18-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
UniChem
US Patent
n/an/an/an/a 3.60E+3n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
To assess the effects of test compounds on GLP-1 or glucagon potency and efficacy, a high-throughput calcium mobilization assay was used essentially ...


US Patent US10487087 (2019)

More data for this
Ligand-Target Pair
Glucagon-like peptide 1 receptor


(Homo sapiens (Human))
BDBM420050
PNG
((R)-N-((1-isopropylpyrrolidin-2-yl)methyl)-10- met...)
Show SMILES CC(C)N1CCC[C@@H]1CNC(=O)c1cn(-c2ccccc2)c(=O)c2c(C)c3ccccc3n12
Show InChI InChI=1S/C27H30N4O2/c1-18(2)29-15-9-12-21(29)16-28-26(32)24-17-30(20-10-5-4-6-11-20)27(33)25-19(3)22-13-7-8-14-23(22)31(24)25/h4-8,10-11,13-14,17-18,21H,9,12,15-16H2,1-3H3,(H,28,32)/t21-/m1/s1
PDB

UniProtKB/SwissProt

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US Patent
n/an/an/an/a>3.00E+4n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
To assess the effects of test compounds on GLP-1 or glucagon potency and efficacy, a high-throughput calcium mobilization assay was used essentially ...


US Patent US10487087 (2019)

More data for this
Ligand-Target Pair
Glucagon-like peptide 1 receptor


(Homo sapiens (Human))
BDBM420051
PNG
((S)-10-cyano-2-cyclopentyl-N-((1- isopropylpyrroli...)
Show SMILES CC(C)N1CCC[C@H]1CNC(=O)c1cn(C2CCCC2)c(=O)c2c(C#N)c3ccccc3n12
Show InChI InChI=1S/C26H31N5O2/c1-17(2)29-13-7-10-19(29)15-28-25(32)23-16-30(18-8-3-4-9-18)26(33)24-21(14-27)20-11-5-6-12-22(20)31(23)24/h5-6,11-12,16-19H,3-4,7-10,13,15H2,1-2H3,(H,28,32)/t19-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
UniChem
US Patent
n/an/an/an/a 1.90E+3n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
To assess the effects of test compounds on GLP-1 or glucagon potency and efficacy, a high-throughput calcium mobilization assay was used essentially ...


US Patent US10487087 (2019)

More data for this
Ligand-Target Pair
Glucagon-like peptide 1 receptor


(Homo sapiens (Human))
BDBM420052
PNG
((S)-2-cyclopentyl-N-((1-isopropylpyrrolidin-2- yl)...)
Show SMILES CC(C)N1CCC[C@H]1CNC(=O)c1cn(C2CCCC2)c(=O)c2c(C=C)c3ccccc3n12
Show InChI InChI=1S/C27H34N4O2/c1-4-21-22-13-7-8-14-23(22)31-24(17-30(27(33)25(21)31)19-10-5-6-11-19)26(32)28-16-20-12-9-15-29(20)18(2)3/h4,7-8,13-14,17-20H,1,5-6,9-12,15-16H2,2-3H3,(H,28,32)/t20-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
UniChem
US Patent
n/an/an/an/a 9.60E+3n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
To assess the effects of test compounds on GLP-1 or glucagon potency and efficacy, a high-throughput calcium mobilization assay was used essentially ...


US Patent US10487087 (2019)

More data for this
Ligand-Target Pair
Glucagon-like peptide 1 receptor


(Homo sapiens (Human))
BDBM420054
PNG
((S)-N-((1-isopropylpyrrolidin-2-yl)methyl)-10- met...)
Show SMILES CC(C)N1CCC[C@H]1CNC(=O)c1cn(-c2cnn(C)c2)c(=O)c2c(C)c3ccccc3n12
Show InChI InChI=1S/C25H30N6O2/c1-16(2)29-11-7-8-18(29)12-26-24(32)22-15-30(19-13-27-28(4)14-19)25(33)23-17(3)20-9-5-6-10-21(20)31(22)23/h5-6,9-10,13-16,18H,7-8,11-12H2,1-4H3,(H,26,32)/t18-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
UniChem
US Patent
n/an/an/an/a 6.70E+3n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
To assess the effects of test compounds on GLP-1 or glucagon potency and efficacy, a high-throughput calcium mobilization assay was used essentially ...


US Patent US10487087 (2019)

More data for this
Ligand-Target Pair
Glucagon-like peptide 1 receptor


(Homo sapiens (Human))
BDBM420037
PNG
((R)-2-cyclopentyl-8-fluoro-N-((1- isopropylpyrroli...)
Show SMILES CC(C)N1CCC[C@@H]1CNC(=O)c1cn(C2CCCC2)c(=O)c2c(C)c3cc(F)ccc3n12
Show InChI InChI=1S/C26H33FN4O2/c1-16(2)29-12-6-9-20(29)14-28-25(32)23-15-30(19-7-4-5-8-19)26(33)24-17(3)21-13-18(27)10-11-22(21)31(23)24/h10-11,13,15-16,19-20H,4-9,12,14H2,1-3H3,(H,28,32)/t20-/m1/s1
PDB

UniProtKB/SwissProt

GoogleScholar
UniChem
US Patent
n/an/an/an/a>3.00E+4n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
To assess the effects of test compounds on GLP-1 or glucagon potency and efficacy, a high-throughput calcium mobilization assay was used essentially ...


US Patent US10487087 (2019)

More data for this
Ligand-Target Pair
Glucagon-like peptide 1 receptor


(Homo sapiens (Human))
BDBM420044
PNG
((R)-10-chloro-2-cyclopentyl-N-((1- isopropylpyrrol...)
Show SMILES CC(C)N1CCC[C@@H]1CNC(=O)c1cn(C2CCCC2)c(=O)c2c(Cl)c3ccccc3n12
Show InChI InChI=1S/C25H31ClN4O2/c1-16(2)28-13-7-10-18(28)14-27-24(31)21-15-29(17-8-3-4-9-17)25(32)23-22(26)19-11-5-6-12-20(19)30(21)23/h5-6,11-12,15-18H,3-4,7-10,13-14H2,1-2H3,(H,27,31)/t18-/m1/s1
PDB

UniProtKB/SwissProt

GoogleScholar
UniChem
US Patent
n/an/an/an/a>3.00E+4n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
To assess the effects of test compounds on GLP-1 or glucagon potency and efficacy, a high-throughput calcium mobilization assay was used essentially ...


US Patent US10487087 (2019)

More data for this
Ligand-Target Pair
Glucagon-like peptide 1 receptor


(Homo sapiens (Human))
BDBM420047
PNG
((S)-10-bromo-2-cyclopentyl-N-((1- isopropylpyrroli...)
Show SMILES CC(C)N1CCC[C@H]1CNC(=O)c1cn(C2CCCC2)c(=O)c2c(Br)c3ccccc3n12
Show InChI InChI=1S/C25H31BrN4O2/c1-16(2)28-13-7-10-18(28)14-27-24(31)21-15-29(17-8-3-4-9-17)25(32)23-22(26)19-11-5-6-12-20(19)30(21)23/h5-6,11-12,15-18H,3-4,7-10,13-14H2,1-2H3,(H,27,31)/t18-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
UniChem
US Patent
n/an/an/an/a 2.20E+3n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
To assess the effects of test compounds on GLP-1 or glucagon potency and efficacy, a high-throughput calcium mobilization assay was used essentially ...


US Patent US10487087 (2019)

More data for this
Ligand-Target Pair
Glucagon-like peptide 1 receptor


(Homo sapiens (Human))
BDBM420029
PNG
((S)-2-Cyclopentyl-N-((1-isopropylpyrrolidin-2-yl)m...)
Show SMILES CC(C)N1CCC[C@H]1CNC(=O)c1cn(C2CCCC2)c(=O)c2c(C)c3ccccc3n12
Show InChI InChI=1S/C26H34N4O2/c1-17(2)28-14-8-11-20(28)15-27-25(31)23-16-29(19-9-4-5-10-19)26(32)24-18(3)21-12-6-7-13-22(21)30(23)24/h6-7,12-13,16-17,19-20H,4-5,8-11,14-15H2,1-3H3,(H,27,31)/t20-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
UniChem
US Patent
n/an/an/an/a 2.70E+3n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
To assess the effects of test compounds on GLP-1 or glucagon potency and efficacy, a high-throughput calcium mobilization assay was used essentially ...


US Patent US10487087 (2019)

More data for this
Ligand-Target Pair
Glucagon-like peptide 1 receptor


(Homo sapiens (Human))
BDBM420032
PNG
(N-(((S)-1-isopropylpyrrolidin-2-yl)methyl)-10- met...)
Show SMILES CC(C)N1CCC[C@H]1CNC(=O)c1cn([C@H]2CCOC2)c(=O)c2c(C)c3ccccc3n12
Show InChI InChI=1S/C25H32N4O3/c1-16(2)27-11-6-7-18(27)13-26-24(30)22-14-28(19-10-12-32-15-19)25(31)23-17(3)20-8-4-5-9-21(20)29(22)23/h4-5,8-9,14,16,18-19H,6-7,10-13,15H2,1-3H3,(H,26,30)/t18-,19-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
UniChem
US Patent
n/an/an/an/a 2.90E+3n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
To assess the effects of test compounds on GLP-1 or glucagon potency and efficacy, a high-throughput calcium mobilization assay was used essentially ...


US Patent US10487087 (2019)

More data for this
Ligand-Target Pair
Glucagon-like peptide 1 receptor


(Homo sapiens (Human))
BDBM420034
PNG
((S)-2-cyclopentyl-8-fluoro-N-((1- isopropylpyrroli...)
Show SMILES CC(C)N1CCC[C@H]1CNC(=O)c1cn(C2CCCC2)c(=O)c2c(C)c3cc(F)ccc3n12
Show InChI InChI=1S/C26H33FN4O2/c1-16(2)29-12-6-9-20(29)14-28-25(32)23-15-30(19-7-4-5-8-19)26(33)24-17(3)21-13-18(27)10-11-22(21)31(23)24/h10-11,13,15-16,19-20H,4-9,12,14H2,1-3H3,(H,28,32)/t20-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
UniChem
US Patent
n/an/an/an/a 4.40E+3n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
To assess the effects of test compounds on GLP-1 or glucagon potency and efficacy, a high-throughput calcium mobilization assay was used essentially ...


US Patent US10487087 (2019)

More data for this
Ligand-Target Pair
Glucagon-like peptide 1 receptor


(Homo sapiens (Human))
BDBM420044
PNG
((R)-10-chloro-2-cyclopentyl-N-((1- isopropylpyrrol...)
Show SMILES CC(C)N1CCC[C@@H]1CNC(=O)c1cn(C2CCCC2)c(=O)c2c(Cl)c3ccccc3n12
Show InChI InChI=1S/C25H31ClN4O2/c1-16(2)28-13-7-10-18(28)14-27-24(31)21-15-29(17-8-3-4-9-17)25(32)23-22(26)19-11-5-6-12-20(19)30(21)23/h5-6,11-12,15-18H,3-4,7-10,13-14H2,1-2H3,(H,27,31)/t18-/m1/s1
PDB

UniProtKB/SwissProt

GoogleScholar
UniChem
US Patent
n/an/an/an/a>3.00E+4n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
To assess the effects of test compounds on GLP-1 or glucagon potency and efficacy, a high-throughput calcium mobilization assay was used essentially ...


US Patent US10487087 (2019)

More data for this
Ligand-Target Pair
Glucagon-like peptide 1 receptor


(Homo sapiens (Human))
BDBM420055
PNG
((R)-N-((1-isopropylpyrrolidin-2-yl)methyl)-10- met...)
Show SMILES CC(C)N1CCC[C@@H]1CNC(=O)c1cn(-c2cnn(C)c2)c(=O)c2c(C)c3ccccc3n12
Show InChI InChI=1S/C25H30N6O2/c1-16(2)29-11-7-8-18(29)12-26-24(32)22-15-30(19-13-27-28(4)14-19)25(33)23-17(3)20-9-5-6-10-21(20)31(22)23/h5-6,9-10,13-16,18H,7-8,11-12H2,1-4H3,(H,26,32)/t18-/m1/s1
PDB

UniProtKB/SwissProt

GoogleScholar
UniChem
US Patent
n/an/an/an/a>3.00E+4n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
To assess the effects of test compounds on GLP-1 or glucagon potency and efficacy, a high-throughput calcium mobilization assay was used essentially ...


US Patent US10487087 (2019)

More data for this
Ligand-Target Pair
Glucagon-like peptide 1 receptor


(Homo sapiens (Human))
BDBM420029
PNG
((S)-2-Cyclopentyl-N-((1-isopropylpyrrolidin-2-yl)m...)
Show SMILES CC(C)N1CCC[C@H]1CNC(=O)c1cn(C2CCCC2)c(=O)c2c(C)c3ccccc3n12
Show InChI InChI=1S/C26H34N4O2/c1-17(2)28-14-8-11-20(28)15-27-25(31)23-16-29(19-9-4-5-10-19)26(32)24-18(3)21-12-6-7-13-22(21)30(23)24/h6-7,12-13,16-17,19-20H,4-5,8-11,14-15H2,1-3H3,(H,27,31)/t20-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
UniChem
US Patent
n/an/an/an/a 4.60E+3n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
To assess the effects of test compounds on GLP-1 or glucagon potency and efficacy, a high-throughput calcium mobilization assay was used essentially ...


US Patent US10487087 (2019)

More data for this
Ligand-Target Pair
Glucagon-like peptide 1 receptor


(Homo sapiens (Human))
BDBM420043
PNG
((S)-10-chloro-2-cyclopentyl-N-((1- isopropylpyrrol...)
Show SMILES CC(C)N1CCC[C@H]1CNC(=O)c1cn(C2CCCC2)c(=O)c2c(Cl)c3ccccc3n12
Show InChI InChI=1S/C25H31ClN4O2/c1-16(2)28-13-7-10-18(28)14-27-24(31)21-15-29(17-8-3-4-9-17)25(32)23-22(26)19-11-5-6-12-20(19)30(21)23/h5-6,11-12,15-18H,3-4,7-10,13-14H2,1-2H3,(H,27,31)/t18-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
UniChem
US Patent
n/an/an/an/a 1.30E+3n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
To assess the effects of test compounds on GLP-1 or glucagon potency and efficacy, a high-throughput calcium mobilization assay was used essentially ...


US Patent US10487087 (2019)

More data for this
Ligand-Target Pair
Glucagon-like peptide 1 receptor


(Homo sapiens (Human))
BDBM420043
PNG
((S)-10-chloro-2-cyclopentyl-N-((1- isopropylpyrrol...)
Show SMILES CC(C)N1CCC[C@H]1CNC(=O)c1cn(C2CCCC2)c(=O)c2c(Cl)c3ccccc3n12
Show InChI InChI=1S/C25H31ClN4O2/c1-16(2)28-13-7-10-18(28)14-27-24(31)21-15-29(17-8-3-4-9-17)25(32)23-22(26)19-11-5-6-12-20(19)30(21)23/h5-6,11-12,15-18H,3-4,7-10,13-14H2,1-2H3,(H,27,31)/t18-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
UniChem
US Patent
n/an/an/an/a 1.50E+3n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
To assess the effects of test compounds on GLP-1 or glucagon potency and efficacy, a high-throughput calcium mobilization assay was used essentially ...


US Patent US10487087 (2019)

More data for this
Ligand-Target Pair
Glucagon-like peptide 1 receptor


(Homo sapiens (Human))
BDBM420049
PNG
((S)-N-((1-isopropylpyrrolidin-2-yl)methyl)-10- met...)
Show SMILES CC(C)N1CCC[C@H]1CNC(=O)c1cn(-c2ccccc2)c(=O)c2c(C)c3ccccc3n12
Show InChI InChI=1S/C27H30N4O2/c1-18(2)29-15-9-12-21(29)16-28-26(32)24-17-30(20-10-5-4-6-11-20)27(33)25-19(3)22-13-7-8-14-23(22)31(24)25/h4-8,10-11,13-14,17-18,21H,9,12,15-16H2,1-3H3,(H,28,32)/t21-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
UniChem
US Patent
n/an/an/an/a 1.30E+4n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
To assess the effects of test compounds on GLP-1 or glucagon potency and efficacy, a high-throughput calcium mobilization assay was used essentially ...


US Patent US10487087 (2019)

More data for this
Ligand-Target Pair
Glucagon-like peptide 1 receptor


(Homo sapiens (Human))
BDBM420031
PNG
(2-cyclopentyl-N-(((S)-1-isopropylpyrrolidin-2- yl)...)
Show SMILES CC(C)N1CCC[C@H]1CNC(=O)C1CN(C2CCCC2)C(=O)c2c(C)c3ccccc3n12
Show InChI InChI=1S/C26H36N4O2/c1-17(2)28-14-8-11-20(28)15-27-25(31)23-16-29(19-9-4-5-10-19)26(32)24-18(3)21-12-6-7-13-22(21)30(23)24/h6-7,12-13,17,19-20,23H,4-5,8-11,14-16H2,1-3H3,(H,27,31)/t20-,23?/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
UniChem
US Patent
n/an/an/an/a 1.10E+4n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
To assess the effects of test compounds on GLP-1 or glucagon potency and efficacy, a high-throughput calcium mobilization assay was used essentially ...


US Patent US10487087 (2019)

More data for this
Ligand-Target Pair
Glucagon-like peptide 1 receptor


(Homo sapiens (Human))
BDBM420033
PNG
(N-(((R)-1-isopropylpyrrolidin-2-yl)methyl)-10- met...)
Show SMILES CC(C)N1CCC[C@@H]1CNC(=O)c1cn([C@H]2CCOC2)c(=O)c2c(C)c3ccccc3n12
Show InChI InChI=1S/C25H32N4O3/c1-16(2)27-11-6-7-18(27)13-26-24(30)22-14-28(19-10-12-32-15-19)25(31)23-17(3)20-8-4-5-9-21(20)29(22)23/h4-5,8-9,14,16,18-19H,6-7,10-13,15H2,1-3H3,(H,26,30)/t18-,19+/m1/s1
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n/an/an/an/a 4.20E+3n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
To assess the effects of test compounds on GLP-1 or glucagon potency and efficacy, a high-throughput calcium mobilization assay was used essentially ...


US Patent US10487087 (2019)

More data for this
Ligand-Target Pair
Glucagon-like peptide 1 receptor


(Homo sapiens (Human))
BDBM420034
PNG
((S)-2-cyclopentyl-8-fluoro-N-((1- isopropylpyrroli...)
Show SMILES CC(C)N1CCC[C@H]1CNC(=O)c1cn(C2CCCC2)c(=O)c2c(C)c3cc(F)ccc3n12
Show InChI InChI=1S/C26H33FN4O2/c1-16(2)29-12-6-9-20(29)14-28-25(32)23-15-30(19-7-4-5-8-19)26(33)24-17(3)21-13-18(27)10-11-22(21)31(23)24/h10-11,13,15-16,19-20H,4-9,12,14H2,1-3H3,(H,28,32)/t20-/m0/s1
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n/an/an/an/a 6.10E+3n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
To assess the effects of test compounds on GLP-1 or glucagon potency and efficacy, a high-throughput calcium mobilization assay was used essentially ...


US Patent US10487087 (2019)

More data for this
Ligand-Target Pair
Glucagon-like peptide 1 receptor


(Homo sapiens (Human))
BDBM420057
PNG
((R)-N-((1-isopropylpyrrolidin-2-yl)methyl)-10- met...)
Show SMILES CC(C)N1CCC[C@@H]1CNC(=O)c1cn(-c2cccnc2)c(=O)c2c(C)c3ccccc3n12
Show InChI InChI=1S/C26H29N5O2/c1-17(2)29-13-7-9-20(29)15-28-25(32)23-16-30(19-8-6-12-27-14-19)26(33)24-18(3)21-10-4-5-11-22(21)31(23)24/h4-6,8,10-12,14,16-17,20H,7,9,13,15H2,1-3H3,(H,28,32)/t20-/m1/s1
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n/an/an/an/a>3.00E+4n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
To assess the effects of test compounds on GLP-1 or glucagon potency and efficacy, a high-throughput calcium mobilization assay was used essentially ...


US Patent US10487087 (2019)

More data for this
Ligand-Target Pair
Glucagon-like peptide 1 receptor


(Homo sapiens (Human))
BDBM420031
PNG
(2-cyclopentyl-N-(((S)-1-isopropylpyrrolidin-2- yl)...)
Show SMILES CC(C)N1CCC[C@H]1CNC(=O)C1CN(C2CCCC2)C(=O)c2c(C)c3ccccc3n12
Show InChI InChI=1S/C26H36N4O2/c1-17(2)28-14-8-11-20(28)15-27-25(31)23-16-29(19-9-4-5-10-19)26(32)24-18(3)21-12-6-7-13-22(21)30(23)24/h6-7,12-13,17,19-20,23H,4-5,8-11,14-16H2,1-3H3,(H,27,31)/t20-,23?/m0/s1
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n/an/an/an/a 5.70E+3n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
To assess the effects of test compounds on GLP-1 or glucagon potency and efficacy, a high-throughput calcium mobilization assay was used essentially ...


US Patent US10487087 (2019)

More data for this
Ligand-Target Pair
Glucagon-like peptide 1 receptor


(Homo sapiens (Human))
BDBM420033
PNG
(N-(((R)-1-isopropylpyrrolidin-2-yl)methyl)-10- met...)
Show SMILES CC(C)N1CCC[C@@H]1CNC(=O)c1cn([C@H]2CCOC2)c(=O)c2c(C)c3ccccc3n12
Show InChI InChI=1S/C25H32N4O3/c1-16(2)27-11-6-7-18(27)13-26-24(30)22-14-28(19-10-12-32-15-19)25(31)23-17(3)20-8-4-5-9-21(20)29(22)23/h4-5,8-9,14,16,18-19H,6-7,10-13,15H2,1-3H3,(H,26,30)/t18-,19+/m1/s1
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n/an/an/an/a 5.90E+3n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
To assess the effects of test compounds on GLP-1 or glucagon potency and efficacy, a high-throughput calcium mobilization assay was used essentially ...


US Patent US10487087 (2019)

More data for this
Ligand-Target Pair
Glucagon-like peptide 1 receptor


(Homo sapiens (Human))
BDBM420037
PNG
((R)-2-cyclopentyl-8-fluoro-N-((1- isopropylpyrroli...)
Show SMILES CC(C)N1CCC[C@@H]1CNC(=O)c1cn(C2CCCC2)c(=O)c2c(C)c3cc(F)ccc3n12
Show InChI InChI=1S/C26H33FN4O2/c1-16(2)29-12-6-9-20(29)14-28-25(32)23-15-30(19-7-4-5-8-19)26(33)24-17(3)21-13-18(27)10-11-22(21)31(23)24/h10-11,13,15-16,19-20H,4-9,12,14H2,1-3H3,(H,28,32)/t20-/m1/s1
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n/an/an/an/a>3.00E+4n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
To assess the effects of test compounds on GLP-1 or glucagon potency and efficacy, a high-throughput calcium mobilization assay was used essentially ...


US Patent US10487087 (2019)

More data for this
Ligand-Target Pair
Glucagon-like peptide 1 receptor


(Homo sapiens (Human))
BDBM420038
PNG
((R)-2-cyclopentyl-N-(((S)-1-isopropylpyrrolidin-2-...)
Show SMILES CC(C)N1CCC[C@H]1CNC(=O)[C@H]1CN(C2CCCC2)C(=O)c2c(C)c3ccccc3n12
Show InChI InChI=1S/C26H36N4O2/c1-17(2)28-14-8-11-20(28)15-27-25(31)23-16-29(19-9-4-5-10-19)26(32)24-18(3)21-12-6-7-13-22(21)30(23)24/h6-7,12-13,17,19-20,23H,4-5,8-11,14-16H2,1-3H3,(H,27,31)/t20-,23+/m0/s1
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n/an/an/an/a 3.60E+3n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
To assess the effects of test compounds on GLP-1 or glucagon potency and efficacy, a high-throughput calcium mobilization assay was used essentially ...


US Patent US10487087 (2019)

More data for this
Ligand-Target Pair
Glucagon-like peptide 1 receptor


(Homo sapiens (Human))
BDBM420039
PNG
((S)-2-cyclopentyl-N-(((S)-1-isopropylpyrrolidin-2-...)
Show SMILES CC(C)N1CCC[C@H]1CNC(=O)[C@@H]1CN(C2CCCC2)C(=O)c2c(C)c3ccccc3n12
Show InChI InChI=1S/C26H36N4O2/c1-17(2)28-14-8-11-20(28)15-27-25(31)23-16-29(19-9-4-5-10-19)26(32)24-18(3)21-12-6-7-13-22(21)30(23)24/h6-7,12-13,17,19-20,23H,4-5,8-11,14-16H2,1-3H3,(H,27,31)/t20-,23-/m0/s1
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n/an/an/an/a>3.00E+4n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
To assess the effects of test compounds on GLP-1 or glucagon potency and efficacy, a high-throughput calcium mobilization assay was used essentially ...


US Patent US10487087 (2019)

More data for this
Ligand-Target Pair
Glucagon-like peptide 1 receptor


(Homo sapiens (Human))
BDBM420027
PNG
(US10487087, Compound I)
Show SMILES Cc1c2ccccc2n2c(cn(C3CCCC3)c(=O)c12)C(O)=O
Show InChI InChI=1S/C18H18N2O3/c1-11-13-8-4-5-9-14(13)20-15(18(22)23)10-19(17(21)16(11)20)12-6-2-3-7-12/h4-5,8-10,12H,2-3,6-7H2,1H3,(H,22,23)
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n/an/an/an/a>3.00E+4n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
To assess the effects of test compounds on GLP-1 or glucagon potency and efficacy, a high-throughput calcium mobilization assay was used essentially ...


US Patent US10487087 (2019)

More data for this
Ligand-Target Pair
Glucagon-like peptide 1 receptor


(Homo sapiens (Human))
BDBM420038
PNG
((R)-2-cyclopentyl-N-(((S)-1-isopropylpyrrolidin-2-...)
Show SMILES CC(C)N1CCC[C@H]1CNC(=O)[C@H]1CN(C2CCCC2)C(=O)c2c(C)c3ccccc3n12
Show InChI InChI=1S/C26H36N4O2/c1-17(2)28-14-8-11-20(28)15-27-25(31)23-16-29(19-9-4-5-10-19)26(32)24-18(3)21-12-6-7-13-22(21)30(23)24/h6-7,12-13,17,19-20,23H,4-5,8-11,14-16H2,1-3H3,(H,27,31)/t20-,23+/m0/s1
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n/an/an/an/a 3.60E+3n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
To assess the effects of test compounds on GLP-1 or glucagon potency and efficacy, a high-throughput calcium mobilization assay was used essentially ...


US Patent US10487087 (2019)

More data for this
Ligand-Target Pair
Glucagon-like peptide 1 receptor


(Homo sapiens (Human))
BDBM420048
PNG
((R)-10-bromo-2-cyclopentyl-N-((1- isopropylpyrroli...)
Show SMILES CC(C)N1CCC[C@@H]1CNC(=O)c1cn(C2CCCC2)c(=O)c2c(Br)c3ccccc3n12
Show InChI InChI=1S/C25H31BrN4O2/c1-16(2)28-13-7-10-18(28)14-27-24(31)21-15-29(17-8-3-4-9-17)25(32)23-22(26)19-11-5-6-12-20(19)30(21)23/h5-6,11-12,15-18H,3-4,7-10,13-14H2,1-2H3,(H,27,31)/t18-/m1/s1
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n/an/an/an/a>3.00E+4n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
To assess the effects of test compounds on GLP-1 or glucagon potency and efficacy, a high-throughput calcium mobilization assay was used essentially ...


US Patent US10487087 (2019)

More data for this
Ligand-Target Pair
Glucagon-like peptide 1 receptor


(Homo sapiens (Human))
BDBM420030
PNG
((R)-2-cyclopentyl-N-((1-isopropylpyrrolidin-2- yl)...)
Show SMILES CC(C)N1CCC[C@@H]1CNC(=O)c1cn(C2CCCC2)c(=O)c2c(C)c3ccccc3n12
Show InChI InChI=1S/C26H34N4O2/c1-17(2)28-14-8-11-20(28)15-27-25(31)23-16-29(19-9-4-5-10-19)26(32)24-18(3)21-12-6-7-13-22(21)30(23)24/h6-7,12-13,16-17,19-20H,4-5,8-11,14-15H2,1-3H3,(H,27,31)/t20-/m1/s1
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n/an/an/an/a>3.00E+4n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
To assess the effects of test compounds on GLP-1 or glucagon potency and efficacy, a high-throughput calcium mobilization assay was used essentially ...


US Patent US10487087 (2019)

More data for this
Ligand-Target Pair
Glucagon-like peptide 1 receptor


(Homo sapiens (Human))
BDBM420039
PNG
((S)-2-cyclopentyl-N-(((S)-1-isopropylpyrrolidin-2-...)
Show SMILES CC(C)N1CCC[C@H]1CNC(=O)[C@@H]1CN(C2CCCC2)C(=O)c2c(C)c3ccccc3n12
Show InChI InChI=1S/C26H36N4O2/c1-17(2)28-14-8-11-20(28)15-27-25(31)23-16-29(19-9-4-5-10-19)26(32)24-18(3)21-12-6-7-13-22(21)30(23)24/h6-7,12-13,17,19-20,23H,4-5,8-11,14-16H2,1-3H3,(H,27,31)/t20-,23-/m0/s1
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n/an/an/an/a>3.00E+4n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
To assess the effects of test compounds on GLP-1 or glucagon potency and efficacy, a high-throughput calcium mobilization assay was used essentially ...


US Patent US10487087 (2019)

More data for this
Ligand-Target Pair
Glucagon-like peptide 1 receptor


(Homo sapiens (Human))
BDBM420048
PNG
((R)-10-bromo-2-cyclopentyl-N-((1- isopropylpyrroli...)
Show SMILES CC(C)N1CCC[C@@H]1CNC(=O)c1cn(C2CCCC2)c(=O)c2c(Br)c3ccccc3n12
Show InChI InChI=1S/C25H31BrN4O2/c1-16(2)28-13-7-10-18(28)14-27-24(31)21-15-29(17-8-3-4-9-17)25(32)23-22(26)19-11-5-6-12-20(19)30(21)23/h5-6,11-12,15-18H,3-4,7-10,13-14H2,1-2H3,(H,27,31)/t18-/m1/s1
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n/an/an/an/a>3.00E+4n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
To assess the effects of test compounds on GLP-1 or glucagon potency and efficacy, a high-throughput calcium mobilization assay was used essentially ...


US Patent US10487087 (2019)

More data for this
Ligand-Target Pair
Glucagon-like peptide 1 receptor


(Homo sapiens (Human))
BDBM420056
PNG
((S)-N-((1-isopropylpyrrolidin-2-yl)methyl)-10- met...)
Show SMILES CC(C)N1CCC[C@H]1CNC(=O)c1cn(-c2cccnc2)c(=O)c2c(C)c3ccccc3n12
Show InChI InChI=1S/C26H29N5O2/c1-17(2)29-13-7-9-20(29)15-28-25(32)23-16-30(19-8-6-12-27-14-19)26(33)24-18(3)21-10-4-5-11-22(21)31(23)24/h4-6,8,10-12,14,16-17,20H,7,9,13,15H2,1-3H3,(H,28,32)/t20-/m0/s1
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n/an/an/an/a 5.20E+3n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
To assess the effects of test compounds on GLP-1 or glucagon potency and efficacy, a high-throughput calcium mobilization assay was used essentially ...


US Patent US10487087 (2019)

More data for this
Ligand-Target Pair
Glucagon-like peptide 1 receptor


(Homo sapiens (Human))
BDBM420059
PNG
(N-(azetidin-2-ylmethyl)-2-cyclopentyl-10-methyl- 1...)
Show SMILES Cc1c2ccccc2n2c(cn(C3CCCC3)c(=O)c12)C(=O)NCC1CCN1
Show InChI InChI=1S/C22H26N4O2/c1-14-17-8-4-5-9-18(17)26-19(21(27)24-12-15-10-11-23-15)13-25(22(28)20(14)26)16-6-2-3-7-16/h4-5,8-9,13,15-16,23H,2-3,6-7,10-12H2,1H3,(H,24,27)
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n/an/an/an/a>3.00E+4n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
To assess the effects of test compounds on GLP-1 or glucagon potency and efficacy, a high-throughput calcium mobilization assay was used essentially ...


US Patent US10487087 (2019)

More data for this
Ligand-Target Pair
Glucagon-like peptide 1 receptor


(Homo sapiens (Human))
BDBM420061
PNG
(2-cyclopentyl-4-(hydroxymethyl)-10- methylpyrazino...)
Show SMILES Cc1c2ccccc2n2c(CO)cn(C3CCCC3)c(=O)c12
Show InChI InChI=1S/C18H20N2O2/c1-12-15-8-4-5-9-16(15)20-14(11-21)10-19(18(22)17(12)20)13-6-2-3-7-13/h4-5,8-10,13,21H,2-3,6-7,11H2,1H3
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n/an/an/an/a>3.00E+4n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
To assess the effects of test compounds on GLP-1 or glucagon potency and efficacy, a high-throughput calcium mobilization assay was used essentially ...


US Patent US10487087 (2019)

More data for this
Ligand-Target Pair
Glucagon-like peptide 1 receptor


(Homo sapiens (Human))
BDBM420032
PNG
(N-(((S)-1-isopropylpyrrolidin-2-yl)methyl)-10- met...)
Show SMILES CC(C)N1CCC[C@H]1CNC(=O)c1cn([C@H]2CCOC2)c(=O)c2c(C)c3ccccc3n12
Show InChI InChI=1S/C25H32N4O3/c1-16(2)27-11-6-7-18(27)13-26-24(30)22-14-28(19-10-12-32-15-19)25(31)23-17(3)20-8-4-5-9-21(20)29(22)23/h4-5,8-9,14,16,18-19H,6-7,10-13,15H2,1-3H3,(H,26,30)/t18-,19-/m0/s1
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n/an/an/an/a 2.40E+3n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
To assess the effects of test compounds on GLP-1 or glucagon potency and efficacy, a high-throughput calcium mobilization assay was used essentially ...


US Patent US10487087 (2019)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%