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Patent code US10487092

Compile Data Set for Download or QSAR
Found 126 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1)


(Homo sapiens (Human))
BDBM420157
PNG
((7S)-4-[(6-Chloropyrazolo[1,5-a]pyridin-5-yl)amino...)
Show SMILES CN(C)[C@H]1CCN(C1)C(=O)[C@H]1CCc2c(C1)sc1ncnc(Nc3cc4ccnn4cc3Cl)c21
Show InChI InChI=1S/C24H26ClN7OS/c1-30(2)16-6-8-31(11-16)24(33)14-3-4-17-20(9-14)34-23-21(17)22(26-13-27-23)29-19-10-15-5-7-28-32(15)12-18(19)25/h5,7,10,12-14,16H,3-4,6,8-9,11H2,1-2H3,(H,26,27,29)/t14-,16-/m0/s1
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n/an/a 1n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
A recombinant fusion protein of Glutathione-S-Transferase (GST, N-terminally) and human full-length MKNK1 (amino acids 1-424 and T344D of accession n...


US Patent US10487092 (2019)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1)


(Homo sapiens (Human))
BDBM420251
PNG
((7S)óN-[3-(Dimethylamino)propyl]-4-[(6-methoxypyra...)
Show SMILES COc1cn2nccc2cc1Nc1ncnc2sc3C[C@H](CCc3c12)C(=O)N(C)CCCN(C)C
Show InChI InChI=1S/C25H31N7O2S/c1-30(2)10-5-11-31(3)25(33)16-6-7-18-21(12-16)35-24-22(18)23(26-15-27-24)29-19-13-17-8-9-28-32(17)14-20(19)34-4/h8-9,13-16H,5-7,10-12H2,1-4H3,(H,26,27,29)/t16-/m0/s1
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n/an/a 1n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
A recombinant fusion protein of Glutathione-S-Transferase (GST, N-terminally) and human full-length MKNK1 (amino acids 1-424 and T344D of accession n...


US Patent US10487092 (2019)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1)


(Homo sapiens (Human))
BDBM420262
PNG
((4-[2-Dimethylamino)ethyl]methyl)aminopiperidin-1-...)
Show SMILES COc1cn2nccc2cc1Nc1ncnc2sc3C[C@H](CCc3c12)C(=O)N1CCC(CC1)N(C)CCN(C)C
Show InChI InChI=1S/C29H38N8O2S/c1-34(2)13-14-35(3)20-8-11-36(12-9-20)29(38)19-5-6-22-25(15-19)40-28-26(22)27(30-18-31-28)33-23-16-21-7-10-32-37(21)17-24(23)39-4/h7,10,16-20H,5-6,8-9,11-15H2,1-4H3,(H,30,31,33)/t19-/m0/s1
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n/an/a<1n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
A recombinant fusion protein of Glutathione-S-Transferase (GST, N-terminally) and human full-length MKNK1 (amino acids 1-424 and T344D of accession n...


US Patent US10487092 (2019)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1)


(Homo sapiens (Human))
BDBM420261
PNG
(US10487092, Example 109 | [4-(Dimethylamino)piperi...)
Show SMILES COc1cn2nccc2cc1Nc1ncnc2sc3C[C@H](CCc3c12)C(=O)N1CCC(CC1)N(C)C
Show InChI InChI=1S/C26H31N7O2S/c1-31(2)17-7-10-32(11-8-17)26(34)16-4-5-19-22(12-16)36-25-23(19)24(27-15-28-25)30-20-13-18-6-9-29-33(18)14-21(20)35-3/h6,9,13-17H,4-5,7-8,10-12H2,1-3H3,(H,27,28,30)/t16-/m0/s1
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n/an/a 1n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
A recombinant fusion protein of Glutathione-S-Transferase (GST, N-terminally) and human full-length MKNK1 (amino acids 1-424 and T344D of accession n...


US Patent US10487092 (2019)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1)


(Homo sapiens (Human))
BDBM420278
PNG
((7S)-4-[(6-Methoxypyrazolo[1,5-a]pyridin-5-yl)amin...)
Show SMILES COc1cn2nccc2cc1Nc1ncnc2sc3C[C@H](CCc3c12)C(=O)N1CCOC[C@H]1C
Show InChI InChI=1S/C24H26N6O3S/c1-14-12-33-8-7-29(14)24(31)15-3-4-17-20(9-15)34-23-21(17)22(25-13-26-23)28-18-10-16-5-6-27-30(16)11-19(18)32-2/h5-6,10-11,13-15H,3-4,7-9,12H2,1-2H3,(H,25,26,28)/t14-,15+/m1/s1
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n/an/a 1n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
A recombinant fusion protein of Glutathione-S-Transferase (GST, N-terminally) and human full-length MKNK1 (amino acids 1-424 and T344D of accession n...


US Patent US10487092 (2019)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1)


(Homo sapiens (Human))
BDBM420277
PNG
((7S)-4-[(6-Methoxypyrazolo[1,5-a]pyridin-5-yl)amin...)
Show SMILES COc1cn2nccc2cc1Nc1ncnc2sc3C[C@H](CCc3c12)C(=O)N1CCOC[C@@H]1C
Show InChI InChI=1S/C24H26N6O3S/c1-14-12-33-8-7-29(14)24(31)15-3-4-17-20(9-15)34-23-21(17)22(25-13-26-23)28-18-10-16-5-6-27-30(16)11-19(18)32-2/h5-6,10-11,13-15H,3-4,7-9,12H2,1-2H3,(H,25,26,28)/t14-,15-/m0/s1
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n/an/a 1n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
A recombinant fusion protein of Glutathione-S-Transferase (GST, N-terminally) and human full-length MKNK1 (amino acids 1-424 and T344D of accession n...


US Patent US10487092 (2019)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1)


(Homo sapiens (Human))
BDBM420276
PNG
((7S)-4-[(6-Methoxypyrazolo[1,5-a]pyridin-5-yl)amin...)
Show SMILES COc1cn2nccc2cc1Nc1ncnc2sc3C[C@H](CCc3c12)C(=O)N1C[C@H]2C[C@@H]1CO2
Show InChI InChI=1S/C24H24N6O3S/c1-32-19-10-30-14(4-5-27-30)8-18(19)28-22-21-17-3-2-13(6-20(17)34-23(21)26-12-25-22)24(31)29-9-16-7-15(29)11-33-16/h4-5,8,10,12-13,15-16H,2-3,6-7,9,11H2,1H3,(H,25,26,28)/t13-,15+,16+/m0/s1
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n/an/a 1n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
A recombinant fusion protein of Glutathione-S-Transferase (GST, N-terminally) and human full-length MKNK1 (amino acids 1-424 and T344D of accession n...


US Patent US10487092 (2019)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1)


(Homo sapiens (Human))
BDBM420265
PNG
((7S)-4-[(6-Methoxypyrazolo[1,5-a]pyridin-5-yl)amin...)
Show SMILES COc1cn2nccc2cc1Nc1ncnc2sc3C[C@H](CCc3c12)C(=O)N1CCN(C)CC1
Show InChI InChI=1S/C24H27N7O2S/c1-29-7-9-30(10-8-29)24(32)15-3-4-17-20(11-15)34-23-21(17)22(25-14-26-23)28-18-12-16-5-6-27-31(16)13-19(18)33-2/h5-6,12-15H,3-4,7-11H2,1-2H3,(H,25,26,28)/t15-/m0/s1
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n/an/a 1n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
A recombinant fusion protein of Glutathione-S-Transferase (GST, N-terminally) and human full-length MKNK1 (amino acids 1-424 and T344D of accession n...


US Patent US10487092 (2019)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1)


(Homo sapiens (Human))
BDBM420260
PNG
(US10487092, Example 108 | [(3S,4S)-3,4-Dihydroxypy...)
Show SMILES COc1cn2nccc2cc1Nc1ncnc2sc3C[C@H](CCc3c12)C(=O)N1C[C@H](O)[C@@H](O)C1
Show InChI InChI=1S/C23H24N6O4S/c1-33-18-10-29-13(4-5-26-29)7-15(18)27-21-20-14-3-2-12(6-19(14)34-22(20)25-11-24-21)23(32)28-8-16(30)17(31)9-28/h4-5,7,10-12,16-17,30-31H,2-3,6,8-9H2,1H3,(H,24,25,27)/t12-,16-,17-/m0/s1
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n/an/a 1n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
A recombinant fusion protein of Glutathione-S-Transferase (GST, N-terminally) and human full-length MKNK1 (amino acids 1-424 and T344D of accession n...


US Patent US10487092 (2019)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1)


(Homo sapiens (Human))
BDBM420256
PNG
((7S)óN-(2-Methoxyethyl)-4-[(6-methoxypyrazolo[1,5-...)
Show SMILES COCCN(C)C(=O)[C@H]1CCc2c(C1)sc1ncnc(Nc3cc4ccnn4cc3OC)c21
Show InChI InChI=1S/C23H26N6O3S/c1-28(8-9-31-2)23(30)14-4-5-16-19(10-14)33-22-20(16)21(24-13-25-22)27-17-11-15-6-7-26-29(15)12-18(17)32-3/h6-7,11-14H,4-5,8-10H2,1-3H3,(H,24,25,27)/t14-/m0/s1
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n/an/a 1n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
A recombinant fusion protein of Glutathione-S-Transferase (GST, N-terminally) and human full-length MKNK1 (amino acids 1-424 and T344D of accession n...


US Patent US10487092 (2019)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1)


(Homo sapiens (Human))
BDBM420274
PNG
((7S)-4-[(6-Methoxypyrazolo[1,5-a]pyridin-5-yl)amin...)
Show SMILES COc1cn2nccc2cc1Nc1ncnc2sc3C[C@H](CCc3c12)C(=O)N1C[C@H]2C[C@@H]1CN2C
Show InChI InChI=1S/C25H27N7O2S/c1-30-10-17-8-16(30)11-31(17)25(33)14-3-4-18-21(7-14)35-24-22(18)23(26-13-27-24)29-19-9-15-5-6-28-32(15)12-20(19)34-2/h5-6,9,12-14,16-17H,3-4,7-8,10-11H2,1-2H3,(H,26,27,29)/t14-,16+,17+/m0/s1
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n/an/a<1n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
A recombinant fusion protein of Glutathione-S-Transferase (GST, N-terminally) and human full-length MKNK1 (amino acids 1-424 and T344D of accession n...


US Patent US10487092 (2019)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1)


(Homo sapiens (Human))
BDBM420273
PNG
((7S)-4-[(6-Methoxypyrazolo[1,5-a]pyridin-5-yl)amin...)
Show SMILES COc1cn2nccc2cc1Nc1ncnc2sc3C[C@H](CCc3c12)C(=O)N1C[C@@H]2C[C@H]1CN2C
Show InChI InChI=1S/C25H27N7O2S/c1-30-10-17-8-16(30)11-31(17)25(33)14-3-4-18-21(7-14)35-24-22(18)23(26-13-27-24)29-19-9-15-5-6-28-32(15)12-20(19)34-2/h5-6,9,12-14,16-17H,3-4,7-8,10-11H2,1-2H3,(H,26,27,29)/t14-,16-,17-/m0/s1
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n/an/a 1n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
A recombinant fusion protein of Glutathione-S-Transferase (GST, N-terminally) and human full-length MKNK1 (amino acids 1-424 and T344D of accession n...


US Patent US10487092 (2019)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1)


(Homo sapiens (Human))
BDBM420267
PNG
((7S)óN-[2-(Dimethylamino)ethyl]-N-ethyl-4-[(6-meth...)
Show SMILES CCN(CCN(C)C)C(=O)[C@H]1CCc2c(C1)sc1ncnc(Nc3cc4ccnn4cc3OC)c21
Show InChI InChI=1S/C25H31N7O2S/c1-5-31(11-10-30(2)3)25(33)16-6-7-18-21(12-16)35-24-22(18)23(26-15-27-24)29-19-13-17-8-9-28-32(17)14-20(19)34-4/h8-9,13-16H,5-7,10-12H2,1-4H3,(H,26,27,29)/t16-/m0/s1
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n/an/a 1n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
A recombinant fusion protein of Glutathione-S-Transferase (GST, N-terminally) and human full-length MKNK1 (amino acids 1-424 and T344D of accession n...


US Patent US10487092 (2019)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1)


(Homo sapiens (Human))
BDBM420259
PNG
(US10487092, Example 107 | [(3S)-3-(Dimethylamino)p...)
Show SMILES COc1cn2nccc2cc1Nc1ncnc2sc3C[C@H](CCc3c12)C(=O)N1CC[C@@H](C1)N(C)C
Show InChI InChI=1S/C25H29N7O2S/c1-30(2)17-7-9-31(12-17)25(33)15-4-5-18-21(10-15)35-24-22(18)23(26-14-27-24)29-19-11-16-6-8-28-32(16)13-20(19)34-3/h6,8,11,13-15,17H,4-5,7,9-10,12H2,1-3H3,(H,26,27,29)/t15-,17-/m0/s1
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n/an/a<1n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
A recombinant fusion protein of Glutathione-S-Transferase (GST, N-terminally) and human full-length MKNK1 (amino acids 1-424 and T344D of accession n...


US Patent US10487092 (2019)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1)


(Homo sapiens (Human))
BDBM420258
PNG
(US10487092, Example 106 | [(3R)-3-(Dimethylamino)p...)
Show SMILES COc1cn2nccc2cc1Nc1ncnc2sc3C[C@H](CCc3c12)C(=O)N1CC[C@H](C1)N(C)C
Show InChI InChI=1S/C25H29N7O2S/c1-30(2)17-7-9-31(12-17)25(33)15-4-5-18-21(10-15)35-24-22(18)23(26-14-27-24)29-19-11-16-6-8-28-32(16)13-20(19)34-3/h6,8,11,13-15,17H,4-5,7,9-10,12H2,1-3H3,(H,26,27,29)/t15-,17+/m0/s1
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n/an/a<1n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
A recombinant fusion protein of Glutathione-S-Transferase (GST, N-terminally) and human full-length MKNK1 (amino acids 1-424 and T344D of accession n...


US Patent US10487092 (2019)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1)


(Homo sapiens (Human))
BDBM420268
PNG
((7S)-4-[(6-Methoxypyrazolo[1,5-a]pyridin-5-yl)amin...)
Show SMILES COc1cn2nccc2cc1Nc1ncnc2sc3C[C@H](CCc3c12)C(=O)N1CCOCC1
Show InChI InChI=1S/C23H24N6O3S/c1-31-18-12-29-15(4-5-26-29)11-17(18)27-21-20-16-3-2-14(23(30)28-6-8-32-9-7-28)10-19(16)33-22(20)25-13-24-21/h4-5,11-14H,2-3,6-10H2,1H3,(H,24,25,27)/t14-/m0/s1
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n/an/a 1n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
A recombinant fusion protein of Glutathione-S-Transferase (GST, N-terminally) and human full-length MKNK1 (amino acids 1-424 and T344D of accession n...


US Patent US10487092 (2019)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1)


(Homo sapiens (Human))
BDBM420250
PNG
(1-((7S)-4-[(6-Methoxypyrazolo[1,5-a]pyridin-5-yl)a...)
Show SMILES COc1cn2nccc2cc1Nc1ncnc2sc3C[C@H](CCc3c12)C(=O)N1CC(C1)C#N
Show InChI InChI=1S/C23H21N7O2S/c1-32-18-11-30-15(4-5-27-30)7-17(18)28-21-20-16-3-2-14(23(31)29-9-13(8-24)10-29)6-19(16)33-22(20)26-12-25-21/h4-5,7,11-14H,2-3,6,9-10H2,1H3,(H,25,26,28)/t14-/m0/s1
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n/an/a 1n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
A recombinant fusion protein of Glutathione-S-Transferase (GST, N-terminally) and human full-length MKNK1 (amino acids 1-424 and T344D of accession n...


US Patent US10487092 (2019)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1)


(Homo sapiens (Human))
BDBM420271
PNG
((7S)óN,N-Bis(2-methoxyethyl)-4-[(6-methoxypyrazolo...)
Show SMILES COCCN(CCOC)C(=O)[C@H]1CCc2c(C1)sc1ncnc(Nc3cc4ccnn4cc3OC)c21
Show InChI InChI=1S/C25H30N6O4S/c1-33-10-8-30(9-11-34-2)25(32)16-4-5-18-21(12-16)36-24-22(18)23(26-15-27-24)29-19-13-17-6-7-28-31(17)14-20(19)35-3/h6-7,13-16H,4-5,8-12H2,1-3H3,(H,26,27,29)/t16-/m0/s1
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n/an/a<1n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
A recombinant fusion protein of Glutathione-S-Transferase (GST, N-terminally) and human full-length MKNK1 (amino acids 1-424 and T344D of accession n...


US Patent US10487092 (2019)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1)


(Homo sapiens (Human))
BDBM420270
PNG
((7S)óN-Ethyl-N-(2-methoxyethyl)-4-[(6-methoxypyraz...)
Show SMILES CCN(CCOC)C(=O)[C@H]1CCc2c(C1)sc1ncnc(Nc3cc4ccnn4cc3OC)c21
Show InChI InChI=1S/C24H28N6O3S/c1-4-29(9-10-32-2)24(31)15-5-6-17-20(11-15)34-23-21(17)22(25-14-26-23)28-18-12-16-7-8-27-30(16)13-19(18)33-3/h7-8,12-15H,4-6,9-11H2,1-3H3,(H,25,26,28)/t15-/m0/s1
PDB

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n/an/a 1n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
A recombinant fusion protein of Glutathione-S-Transferase (GST, N-terminally) and human full-length MKNK1 (amino acids 1-424 and T344D of accession n...


US Patent US10487092 (2019)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1)


(Homo sapiens (Human))
BDBM420266
PNG
(4-[2-(Dimethylamino)ethyl]piperazin-1-yl(7S)-4-[(6...)
Show SMILES COc1cn2nccc2cc1Nc1ncnc2sc3C[C@H](CCc3c12)C(=O)N1CCN(CCN(C)C)CC1
Show InChI InChI=1S/C27H34N8O2S/c1-32(2)8-9-33-10-12-34(13-11-33)27(36)18-4-5-20-23(14-18)38-26-24(20)25(28-17-29-26)31-21-15-19-6-7-30-35(19)16-22(21)37-3/h6-7,15-18H,4-5,8-14H2,1-3H3,(H,28,29,31)/t18-/m0/s1
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n/an/a<1n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
A recombinant fusion protein of Glutathione-S-Transferase (GST, N-terminally) and human full-length MKNK1 (amino acids 1-424 and T344D of accession n...


US Patent US10487092 (2019)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1)


(Homo sapiens (Human))
BDBM420252
PNG
((3-Hydroxy-3-methylazetidin-1-yl)(7S)-4-[(6-methox...)
Show SMILES COc1cn2nccc2cc1Nc1ncnc2sc3C[C@H](CCc3c12)C(=O)N1CC(C)(O)C1
Show InChI InChI=1S/C23H24N6O3S/c1-23(31)10-28(11-23)22(30)13-3-4-15-18(7-13)33-21-19(15)20(24-12-25-21)27-16-8-14-5-6-26-29(14)9-17(16)32-2/h5-6,8-9,12-13,31H,3-4,7,10-11H2,1-2H3,(H,24,25,27)/t13-/m0/s1
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n/an/a<1n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
A recombinant fusion protein of Glutathione-S-Transferase (GST, N-terminally) and human full-length MKNK1 (amino acids 1-424 and T344D of accession n...


US Patent US10487092 (2019)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1)


(Homo sapiens (Human))
BDBM420249
PNG
((7S)óN-Butyl-4-[(6-methoxypyrazolo[1,5-a]pyridin-5...)
Show SMILES CCCCN(C)C(=O)[C@H]1CCc2c(C1)sc1ncnc(Nc3cc4ccnn4cc3OC)c21
Show InChI InChI=1S/C24H28N6O2S/c1-4-5-10-29(2)24(31)15-6-7-17-20(11-15)33-23-21(17)22(25-14-26-23)28-18-12-16-8-9-27-30(16)13-19(18)32-3/h8-9,12-15H,4-7,10-11H2,1-3H3,(H,25,26,28)/t15-/m0/s1
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n/an/a 1n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
A recombinant fusion protein of Glutathione-S-Transferase (GST, N-terminally) and human full-length MKNK1 (amino acids 1-424 and T344D of accession n...


US Patent US10487092 (2019)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1)


(Homo sapiens (Human))
BDBM420246
PNG
((7S)óN-Ethyl-4-[(6-methoxypyrazolo[1,5-a]pyridin-5...)
Show SMILES CCN(C)C(=O)[C@H]1CCc2c(C1)sc1ncnc(Nc3cc4ccnn4cc3OC)c21
Show InChI InChI=1S/C22H24N6O2S/c1-4-27(2)22(29)13-5-6-15-18(9-13)31-21-19(15)20(23-12-24-21)26-16-10-14-7-8-25-28(14)11-17(16)30-3/h7-8,10-13H,4-6,9H2,1-3H3,(H,23,24,26)/t13-/m0/s1
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n/an/a 1n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
A recombinant fusion protein of Glutathione-S-Transferase (GST, N-terminally) and human full-length MKNK1 (amino acids 1-424 and T344D of accession n...


US Patent US10487092 (2019)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1)


(Homo sapiens (Human))
BDBM420269
PNG
((7S)óN-Ethyl-N-(2-hydroxyethyl)-4-[(6-methoxypyraz...)
Show SMILES CCN(CCO)C(=O)[C@H]1CCc2c(C1)sc1ncnc(Nc3cc4ccnn4cc3OC)c21
Show InChI InChI=1S/C23H26N6O3S/c1-3-28(8-9-30)23(31)14-4-5-16-19(10-14)33-22-20(16)21(24-13-25-22)27-17-11-15-6-7-26-29(15)12-18(17)32-2/h6-7,11-14,30H,3-5,8-10H2,1-2H3,(H,24,25,27)/t14-/m0/s1
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n/an/a 1n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
A recombinant fusion protein of Glutathione-S-Transferase (GST, N-terminally) and human full-length MKNK1 (amino acids 1-424 and T344D of accession n...


US Patent US10487092 (2019)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1)


(Homo sapiens (Human))
BDBM420247
PNG
((7S)óN-(2,2-Difluoroethyl)-4-[(6-methoxypyrazolo[1...)
Show SMILES COc1cn2nccc2cc1Nc1ncnc2sc3C[C@H](CCc3c12)C(=O)N(C)CC(F)F
Show InChI InChI=1S/C22H22F2N6O2S/c1-29(10-18(23)24)22(31)12-3-4-14-17(7-12)33-21-19(14)20(25-11-26-21)28-15-8-13-5-6-27-30(13)9-16(15)32-2/h5-6,8-9,11-12,18H,3-4,7,10H2,1-2H3,(H,25,26,28)/t12-/m0/s1
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n/an/a 2n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
A recombinant fusion protein of Glutathione-S-Transferase (GST, N-terminally) and human full-length MKNK1 (amino acids 1-424 and T344D of accession n...


US Patent US10487092 (2019)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1)


(Homo sapiens (Human))
BDBM420275
PNG
((7S)-4-[(6-Methoxypyrazolo[1,5-a]pyridin-5-yl)amin...)
Show SMILES COc1cn2nccc2cc1Nc1ncnc2sc3C[C@H](CCc3c12)C(=O)N1C[C@@H]2C[C@H]1CO2
Show InChI InChI=1S/C24H24N6O3S/c1-32-19-10-30-14(4-5-27-30)8-18(19)28-22-21-17-3-2-13(6-20(17)34-23(21)26-12-25-22)24(31)29-9-16-7-15(29)11-33-16/h4-5,8,10,12-13,15-16H,2-3,6-7,9,11H2,1H3,(H,25,26,28)/t13-,15-,16-/m0/s1
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n/an/a 2n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
A recombinant fusion protein of Glutathione-S-Transferase (GST, N-terminally) and human full-length MKNK1 (amino acids 1-424 and T344D of accession n...


US Patent US10487092 (2019)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1)


(Homo sapiens (Human))
BDBM420264
PNG
(US10487092, Example 112 | [(2R,6S)-2,6-Dimethylmor...)
Show SMILES COc1cn2nccc2cc1Nc1ncnc2sc3C[C@H](CCc3c12)C(=O)N1C[C@H](C)O[C@H](C)C1
Show InChI InChI=1S/C25H28N6O3S/c1-14-10-30(11-15(2)34-14)25(32)16-4-5-18-21(8-16)35-24-22(18)23(26-13-27-24)29-19-9-17-6-7-28-31(17)12-20(19)33-3/h6-7,9,12-16H,4-5,8,10-11H2,1-3H3,(H,26,27,29)/t14-,15+,16-/m0/s1
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n/an/a 2n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
A recombinant fusion protein of Glutathione-S-Transferase (GST, N-terminally) and human full-length MKNK1 (amino acids 1-424 and T344D of accession n...


US Patent US10487092 (2019)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1)


(Homo sapiens (Human))
BDBM420155
PNG
((7S)-4-[(6-Chloropyrazolo[1,5-a]pyridin-5-yl)amino...)
Show SMILES CN(C)[C@@H]1CCN(C1)C(=O)[C@H]1CCc2c(C1)sc1ncnc(Nc3cc4ccnn4cc3Cl)c21
Show InChI InChI=1S/C24H26ClN7OS/c1-30(2)16-6-8-31(11-16)24(33)14-3-4-17-20(9-14)34-23-21(17)22(26-13-27-23)29-19-10-15-5-7-28-32(15)12-18(19)25/h5,7,10,12-14,16H,3-4,6,8-9,11H2,1-2H3,(H,26,27,29)/t14-,16+/m0/s1
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n/an/a 2n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
A recombinant fusion protein of Glutathione-S-Transferase (GST, N-terminally) and human full-length MKNK1 (amino acids 1-424 and T344D of accession n...


US Patent US10487092 (2019)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1)


(Homo sapiens (Human))
BDBM420253
PNG
((7S)óN-[2-(Dimethylamino)ethyl]-4-[(6-methoxypyraz...)
Show SMILES COc1cn2nccc2cc1Nc1ncnc2sc3C[C@H](CCc3c12)C(=O)N(C)CCN(C)C
Show InChI InChI=1S/C24H29N7O2S/c1-29(2)9-10-30(3)24(32)15-5-6-17-20(11-15)34-23-21(17)22(25-14-26-23)28-18-12-16-7-8-27-31(16)13-19(18)33-4/h7-8,12-15H,5-6,9-11H2,1-4H3,(H,25,26,28)/t15-/m0/s1
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n/an/a 2n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
A recombinant fusion protein of Glutathione-S-Transferase (GST, N-terminally) and human full-length MKNK1 (amino acids 1-424 and T344D of accession n...


US Patent US10487092 (2019)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1)


(Homo sapiens (Human))
BDBM420257
PNG
((7S)-4-[(6-Methoxypyrazolo[1,5-a]pyridin-5-yl)amin...)
Show SMILES COc1cn2nccc2cc1Nc1ncnc2sc3C[C@H](CCc3c12)C(=O)N(C)C(C)C
Show InChI InChI=1S/C23H26N6O2S/c1-13(2)28(3)23(30)14-5-6-16-19(9-14)32-22-20(16)21(24-12-25-22)27-17-10-15-7-8-26-29(15)11-18(17)31-4/h7-8,10-14H,5-6,9H2,1-4H3,(H,24,25,27)/t14-/m0/s1
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n/an/a 2n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
A recombinant fusion protein of Glutathione-S-Transferase (GST, N-terminally) and human full-length MKNK1 (amino acids 1-424 and T344D of accession n...


US Patent US10487092 (2019)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1)


(Homo sapiens (Human))
BDBM420254
PNG
(US10487092, Example 102 | [3-(Dimethylamino)azetid...)
Show SMILES COc1cn2nccc2cc1Nc1ncnc2sc3C[C@H](CCc3c12)C(=O)N1CC(C1)N(C)C
Show InChI InChI=1S/C24H27N7O2S/c1-29(2)16-10-30(11-16)24(32)14-4-5-17-20(8-14)34-23-21(17)22(25-13-26-23)28-18-9-15-6-7-27-31(15)12-19(18)33-3/h6-7,9,12-14,16H,4-5,8,10-11H2,1-3H3,(H,25,26,28)/t14-/m0/s1
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n/an/a 2n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
A recombinant fusion protein of Glutathione-S-Transferase (GST, N-terminally) and human full-length MKNK1 (amino acids 1-424 and T344D of accession n...


US Patent US10487092 (2019)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1)


(Homo sapiens (Human))
BDBM420195
PNG
((7S)óN-(2-Hydroxy-2-methylpropyl)-4-[(6-methoxypyr...)
Show SMILES COc1cn2nccc2nc1Nc1ncnc2sc3C[C@H](CCc3c12)C(=O)NCC(C)(C)O
Show InChI InChI=1S/C22H25N7O3S/c1-22(2,31)10-23-20(30)12-4-5-13-15(8-12)33-21-17(13)19(24-11-25-21)28-18-14(32-3)9-29-16(27-18)6-7-26-29/h6-7,9,11-12,31H,4-5,8,10H2,1-3H3,(H,23,30)(H,24,25,27,28)/t12-/m0/s1
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n/an/a 2n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
A recombinant fusion protein of Glutathione-S-Transferase (GST, N-terminally) and human full-length MKNK1 (amino acids 1-424 and T344D of accession n...


US Patent US10487092 (2019)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1)


(Homo sapiens (Human))
BDBM420197
PNG
((7S)óN-(2-Hydroxyethyl)-4-[(6-methoxypyrazolo[1,5-...)
Show SMILES COc1cn2nccc2nc1Nc1ncnc2sc3C[C@H](CCc3c12)C(=O)NCCO
Show InChI InChI=1S/C20H21N7O3S/c1-30-13-9-27-15(4-5-24-27)25-17(13)26-18-16-12-3-2-11(19(29)21-6-7-28)8-14(12)31-20(16)23-10-22-18/h4-5,9-11,28H,2-3,6-8H2,1H3,(H,21,29)(H,22,23,25,26)/t11-/m0/s1
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n/an/a 3n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
A recombinant fusion protein of Glutathione-S-Transferase (GST, N-terminally) and human full-length MKNK1 (amino acids 1-424 and T344D of accession n...


US Patent US10487092 (2019)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1)


(Homo sapiens (Human))
BDBM420255
PNG
((7S)óN-(2-Hydroxyethyl)-4-[(6-methoxypyrazolo [1,5...)
Show SMILES COc1cn2nccc2cc1Nc1ncnc2sc3C[C@H](CCc3c12)C(=O)N(C)CCO
Show InChI InChI=1S/C22H24N6O3S/c1-27(7-8-29)22(30)13-3-4-15-18(9-13)32-21-19(15)20(23-12-24-21)26-16-10-14-5-6-25-28(14)11-17(16)31-2/h5-6,10-13,29H,3-4,7-9H2,1-2H3,(H,23,24,26)/t13-/m0/s1
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n/an/a 3n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
A recombinant fusion protein of Glutathione-S-Transferase (GST, N-terminally) and human full-length MKNK1 (amino acids 1-424 and T344D of accession n...


US Patent US10487092 (2019)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1)


(Homo sapiens (Human))
BDBM420193
PNG
((7S)óN-(2,2-Difluoroethyl)-4-[(6-methoxypyrazolo[1...)
Show SMILES COc1cn2nccc2nc1Nc1ncnc2sc3C[C@H](CCc3c12)C(=O)NCC(F)F
Show InChI InChI=1S/C20H19F2N7O2S/c1-31-12-8-29-15(4-5-26-29)27-17(12)28-18-16-11-3-2-10(19(30)23-7-14(21)22)6-13(11)32-20(16)25-9-24-18/h4-5,8-10,14H,2-3,6-7H2,1H3,(H,23,30)(H,24,25,27,28)/t10-/m0/s1
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n/an/a 3n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
A recombinant fusion protein of Glutathione-S-Transferase (GST, N-terminally) and human full-length MKNK1 (amino acids 1-424 and T344D of accession n...


US Patent US10487092 (2019)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1)


(Homo sapiens (Human))
BDBM420263
PNG
((7S)óN-[3-(Dimethylamino)propyl]-N-(2-hydroxyethyl...)
Show SMILES COc1cn2nccc2cc1Nc1ncnc2sc3C[C@H](CCc3c12)C(=O)N(CCO)CCCN(C)C
Show InChI InChI=1S/C26H33N7O3S/c1-31(2)9-4-10-32(11-12-34)26(35)17-5-6-19-22(13-17)37-25-23(19)24(27-16-28-25)30-20-14-18-7-8-29-33(18)15-21(20)36-3/h7-8,14-17,34H,4-6,9-13H2,1-3H3,(H,27,28,30)/t17-/m0/s1
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n/an/a 3n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
A recombinant fusion protein of Glutathione-S-Transferase (GST, N-terminally) and human full-length MKNK1 (amino acids 1-424 and T344D of accession n...


US Patent US10487092 (2019)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1)


(Homo sapiens (Human))
BDBM420196
PNG
((7S)óN-[2-(Dimethylamino)ethyl]-4-[(6-methoxypyraz...)
Show SMILES COc1cn2nccc2nc1Nc1ncnc2sc3C[C@H](CCc3c12)C(=O)NCCN(C)C
Show InChI InChI=1S/C22H26N8O2S/c1-29(2)9-8-23-21(31)13-4-5-14-16(10-13)33-22-18(14)20(24-12-25-22)28-19-15(32-3)11-30-17(27-19)6-7-26-30/h6-7,11-13H,4-5,8-10H2,1-3H3,(H,23,31)(H,24,25,27,28)/t13-/m0/s1
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n/an/a 3n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
A recombinant fusion protein of Glutathione-S-Transferase (GST, N-terminally) and human full-length MKNK1 (amino acids 1-424 and T344D of accession n...


US Patent US10487092 (2019)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1)


(Homo sapiens (Human))
BDBM420198
PNG
((7S)óN-(2-Methoxyethyl)-4-[(6-methoxypyrazolo[1,5-...)
Show SMILES COCCNC(=O)[C@H]1CCc2c(C1)sc1ncnc(Nc3nc4ccnn4cc3OC)c21
Show InChI InChI=1S/C21H23N7O3S/c1-30-8-7-22-20(29)12-3-4-13-15(9-12)32-21-17(13)19(23-11-24-21)27-18-14(31-2)10-28-16(26-18)5-6-25-28/h5-6,10-12H,3-4,7-9H2,1-2H3,(H,22,29)(H,23,24,26,27)/t12-/m0/s1
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n/an/a 3n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
A recombinant fusion protein of Glutathione-S-Transferase (GST, N-terminally) and human full-length MKNK1 (amino acids 1-424 and T344D of accession n...


US Patent US10487092 (2019)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1)


(Homo sapiens (Human))
BDBM420194
PNG
((7S)-4-[(6-Methoxypyrazolo[1,5-a]pyridin-5-yl)amin...)
Show SMILES COc1cn2nccc2nc1Nc1ncnc2sc3C[C@H](CCc3c12)C(=O)NCCC(F)(F)F
Show InChI InChI=1S/C21H20F3N7O2S/c1-33-13-9-31-15(4-6-28-31)29-17(13)30-18-16-12-3-2-11(19(32)25-7-5-21(22,23)24)8-14(12)34-20(16)27-10-26-18/h4,6,9-11H,2-3,5,7-8H2,1H3,(H,25,32)(H,26,27,29,30)/t11-/m0/s1
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n/an/a 3n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
A recombinant fusion protein of Glutathione-S-Transferase (GST, N-terminally) and human full-length MKNK1 (amino acids 1-424 and T344D of accession n...


US Patent US10487092 (2019)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1)


(Homo sapiens (Human))
BDBM420222
PNG
((7S)óN-(1H-Indol-5-yl)-4-[(6-methoxypyrazolo[1,5-a...)
Show SMILES COc1cn2nccc2cc1Nc1ncnc2sc3C[C@H](CCc3c12)C(=O)Nc1ccc2[nH]ccc2c1
Show InChI InChI=1/C27H23N7O2S/c1-36-22-13-34-18(7-9-31-34)12-21(22)33-25-24-19-4-2-16(11-23(19)37-27(24)30-14-29-25)26(35)32-17-3-5-20-15(10-17)6-8-28-20/h3,5-10,12-14,16,28H,2,4,11H2,1H3,(H,32,35)(H,29,30,33)/t16-/s2
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n/an/a 3n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
A recombinant fusion protein of Glutathione-S-Transferase (GST, N-terminally) and human full-length MKNK1 (amino acids 1-424 and T344D of accession n...


US Patent US10487092 (2019)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1)


(Homo sapiens (Human))
BDBM420201
PNG
((7S)-4-[(6-Methoxypyrazolo[1,5-a]pyridin-5-yl)amin...)
Show SMILES COc1cn2nccc2nc1Nc1ncnc2sc3C[C@H](CCc3c12)C(=O)NC1(C)CCC1
Show InChI InChI=1S/C23H25N7O2S/c1-23(7-3-8-23)29-21(31)13-4-5-14-16(10-13)33-22-18(14)20(24-12-25-22)28-19-15(32-2)11-30-17(27-19)6-9-26-30/h6,9,11-13H,3-5,7-8,10H2,1-2H3,(H,29,31)(H,24,25,27,28)/t13-/m0/s1
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n/an/a 4n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
A recombinant fusion protein of Glutathione-S-Transferase (GST, N-terminally) and human full-length MKNK1 (amino acids 1-424 and T344D of accession n...


US Patent US10487092 (2019)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1)


(Homo sapiens (Human))
BDBM420169
PNG
((7S)-4-[(6-Chloropyrazolo[1,5-a]pyridin-5-yl)amino...)
Show SMILES Clc1cn2nccc2cc1Nc1ncnc2sc3C[C@H](CCc3c12)C(=O)N1CCOCC1
Show InChI InChI=1S/C22H21ClN6O2S/c23-16-11-29-14(3-4-26-29)10-17(16)27-20-19-15-2-1-13(22(30)28-5-7-31-8-6-28)9-18(15)32-21(19)25-12-24-20/h3-4,10-13H,1-2,5-9H2,(H,24,25,27)/t13-/m0/s1
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n/an/a 4n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
A recombinant fusion protein of Glutathione-S-Transferase (GST, N-terminally) and human full-length MKNK1 (amino acids 1-424 and T344D of accession n...


US Patent US10487092 (2019)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1)


(Homo sapiens (Human))
BDBM420184
PNG
((7S)-4-[(6-Chloropyrazolo[1,5-a]pyridin-5-yl)amino...)
Show SMILES CN1C[C@H]2C[C@@H]1CN2C(=O)[C@H]1CCc2c(C1)sc1ncnc(Nc3cc4ccnn4cc3Cl)c21
Show InChI InChI=1S/C24H24ClN7OS/c1-30-9-16-7-15(30)10-31(16)24(33)13-2-3-17-20(6-13)34-23-21(17)22(26-12-27-23)29-19-8-14-4-5-28-32(14)11-18(19)25/h4-5,8,11-13,15-16H,2-3,6-7,9-10H2,1H3,(H,26,27,29)/t13-,15+,16+/m0/s1
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n/an/a 4n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
A recombinant fusion protein of Glutathione-S-Transferase (GST, N-terminally) and human full-length MKNK1 (amino acids 1-424 and T344D of accession n...


US Patent US10487092 (2019)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1)


(Homo sapiens (Human))
BDBM420101
PNG
((7S)-4-[(6-Methoxypyrazolo[1,5-a]pyridin-5-yl)amin...)
Show SMILES COc1cn2nccc2cc1Nc1ncnc2sc3C[C@H](CCc3c12)C(=O)N(C)C
Show InChI InChI=1S/C21H22N6O2S/c1-26(2)21(28)12-4-5-14-17(8-12)30-20-18(14)19(22-11-23-20)25-15-9-13-6-7-24-27(13)10-16(15)29-3/h6-7,9-12H,4-5,8H2,1-3H3,(H,22,23,25)/t12-/m0/s1
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n/an/a 4n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
A recombinant fusion protein of Glutathione-S-Transferase (GST, N-terminally) and human full-length MKNK1 (amino acids 1-424 and T344D of accession n...


US Patent US10487092 (2019)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1)


(Homo sapiens (Human))
BDBM420199
PNG
((7S)-4-[(6-Methoxypyrazolo[1,5-a]pyridin-5-yl)amin...)
Show SMILES COc1cn2nccc2nc1Nc1ncnc2sc3C[C@H](CCc3c12)C(=O)NC(C)C
Show InChI InChI=1S/C21H23N7O2S/c1-11(2)25-20(29)12-4-5-13-15(8-12)31-21-17(13)19(22-10-23-21)27-18-14(30-3)9-28-16(26-18)6-7-24-28/h6-7,9-12H,4-5,8H2,1-3H3,(H,25,29)(H,22,23,26,27)/t12-/m0/s1
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n/an/a 4n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
A recombinant fusion protein of Glutathione-S-Transferase (GST, N-terminally) and human full-length MKNK1 (amino acids 1-424 and T344D of accession n...


US Patent US10487092 (2019)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1)


(Homo sapiens (Human))
BDBM420200
PNG
((7S)óN-tert-Butyl-4-[(6-methoxypyrazolo[1,5-a]pyri...)
Show SMILES COc1cn2nccc2nc1Nc1ncnc2sc3C[C@H](CCc3c12)C(=O)NC(C)(C)C
Show InChI InChI=1S/C22H25N7O2S/c1-22(2,3)28-20(30)12-5-6-13-15(9-12)32-21-17(13)19(23-11-24-21)27-18-14(31-4)10-29-16(26-18)7-8-25-29/h7-8,10-12H,5-6,9H2,1-4H3,(H,28,30)(H,23,24,26,27)/t12-/m0/s1
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n/an/a 4n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
A recombinant fusion protein of Glutathione-S-Transferase (GST, N-terminally) and human full-length MKNK1 (amino acids 1-424 and T344D of accession n...


US Patent US10487092 (2019)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1)


(Homo sapiens (Human))
BDBM420166
PNG
((7S)-4-[(6-Chloropyrazolo[1,5-a]pyridin-5-yl)amino...)
Show SMILES CN1CCN(CC1)C(=O)[C@H]1CCc2c(C1)sc1ncnc(Nc3cc4ccnn4cc3Cl)c21
Show InChI InChI=1S/C23H24ClN7OS/c1-29-6-8-30(9-7-29)23(32)14-2-3-16-19(10-14)33-22-20(16)21(25-13-26-22)28-18-11-15-4-5-27-31(15)12-17(18)24/h4-5,11-14H,2-3,6-10H2,1H3,(H,25,26,28)/t14-/m0/s1
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n/an/a 5n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
A recombinant fusion protein of Glutathione-S-Transferase (GST, N-terminally) and human full-length MKNK1 (amino acids 1-424 and T344D of accession n...


US Patent US10487092 (2019)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1)


(Homo sapiens (Human))
BDBM420272
PNG
((7S)óN-tert-Butyl-4-[(6-methoxypyrazolo[1,5-a]pyri...)
Show SMILES COc1cn2nccc2cc1Nc1ncnc2sc3C[C@H](CCc3c12)C(=O)N(C)C(C)(C)C
Show InChI InChI=1S/C24H28N6O2S/c1-24(2,3)29(4)23(31)14-6-7-16-19(10-14)33-22-20(16)21(25-13-26-22)28-17-11-15-8-9-27-30(15)12-18(17)32-5/h8-9,11-14H,6-7,10H2,1-5H3,(H,25,26,28)/t14-/m0/s1
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n/an/a 5n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
A recombinant fusion protein of Glutathione-S-Transferase (GST, N-terminally) and human full-length MKNK1 (amino acids 1-424 and T344D of accession n...


US Patent US10487092 (2019)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1)


(Homo sapiens (Human))
BDBM420192
PNG
((7S)-4-[(6-Methoxypyrazolo[1,5-a]pyridin-5-yl)amin...)
Show SMILES CNC(=O)[C@H]1CCc2c(C1)sc1ncnc(Nc3cc4ccnn4cc3OC)c21
Show InChI InChI=1S/C20H20N6O2S/c1-21-19(27)11-3-4-13-16(7-11)29-20-17(13)18(22-10-23-20)25-14-8-12-5-6-24-26(12)9-15(14)28-2/h5-6,8-11H,3-4,7H2,1-2H3,(H,21,27)(H,22,23,25)/t11-/m0/s1
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n/an/a 5n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
A recombinant fusion protein of Glutathione-S-Transferase (GST, N-terminally) and human full-length MKNK1 (amino acids 1-424 and T344D of accession n...


US Patent US10487092 (2019)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1)


(Homo sapiens (Human))
BDBM420144
PNG
((7S)-4-[(6-Chloropyrazolo[1,5-a]pyridin-5-yl)amino...)
Show SMILES CN(C)CCCN(C)C(=O)[C@H]1CCc2c(C1)sc1ncnc(Nc3cc4ccnn4cc3Cl)c21
Show InChI InChI=1S/C24H28ClN7OS/c1-30(2)9-4-10-31(3)24(33)15-5-6-17-20(11-15)34-23-21(17)22(26-14-27-23)29-19-12-16-7-8-28-32(16)13-18(19)25/h7-8,12-15H,4-6,9-11H2,1-3H3,(H,26,27,29)/t15-/m0/s1
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n/an/a 5n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
A recombinant fusion protein of Glutathione-S-Transferase (GST, N-terminally) and human full-length MKNK1 (amino acids 1-424 and T344D of accession n...


US Patent US10487092 (2019)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1)


(Homo sapiens (Human))
BDBM420167
PNG
((7S)-4-[(6-Chloropyrazolo[1,5-a]pyridin-5-yl)amino...)
Show SMILES CN(C)CCN1CCN(CC1)C(=O)[C@H]1CCc2c(C1)sc1ncnc(Nc3cc4ccnn4cc3Cl)c21
Show InChI InChI=1S/C26H31ClN8OS/c1-32(2)7-8-33-9-11-34(12-10-33)26(36)17-3-4-19-22(13-17)37-25-23(19)24(28-16-29-25)31-21-14-18-5-6-30-35(18)15-20(21)27/h5-6,14-17H,3-4,7-13H2,1-2H3,(H,28,29,31)/t17-/m0/s1
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n/an/a 6n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
A recombinant fusion protein of Glutathione-S-Transferase (GST, N-terminally) and human full-length MKNK1 (amino acids 1-424 and T344D of accession n...


US Patent US10487092 (2019)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1)


(Homo sapiens (Human))
BDBM420146
PNG
((7S)-4-[(6-Chloropyrazolo[1,5-a]pyridin-5-yl)amino...)
Show SMILES CN(C)CCN(C)C(=O)[C@H]1CCc2c(C1)sc1ncnc(Nc3cc4ccnn4cc3Cl)c21
Show InChI InChI=1S/C23H26ClN7OS/c1-29(2)8-9-30(3)23(32)14-4-5-16-19(10-14)33-22-20(16)21(25-13-26-22)28-18-11-15-6-7-27-31(15)12-17(18)24/h6-7,11-14H,4-5,8-10H2,1-3H3,(H,25,26,28)/t14-/m0/s1
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n/an/a 6n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
A recombinant fusion protein of Glutathione-S-Transferase (GST, N-terminally) and human full-length MKNK1 (amino acids 1-424 and T344D of accession n...


US Patent US10487092 (2019)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1)


(Homo sapiens (Human))
BDBM420133
PNG
((4-{[2-(Dimethylamino)ethyl](methyl)amino}piperidi...)
Show SMILES CN(C)CCN(C)C1CCN(CC1)C(=O)[C@H]1CCc2c(C1)sc1ncnc(Nc3ccn4nccc4c3)c21
Show InChI InChI=1S/C28H36N8OS/c1-33(2)14-15-34(3)21-8-11-35(12-9-21)28(37)19-4-5-23-24(16-19)38-27-25(23)26(29-18-30-27)32-20-7-13-36-22(17-20)6-10-31-36/h6-7,10,13,17-19,21H,4-5,8-9,11-12,14-16H2,1-3H3,(H,29,30,32)/t19-/m0/s1
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n/an/a 6n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
A recombinant fusion protein of Glutathione-S-Transferase (GST, N-terminally) and human full-length MKNK1 (amino acids 1-424 and T344D of accession n...


US Patent US10487092 (2019)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1)


(Homo sapiens (Human))
BDBM420174
PNG
((7S)-4-[(6-Chloropyrazolo[1,5-a]pyridin-5-yl)amino...)
Show SMILES CCN(CCO)C(=O)[C@H]1CCc2c(C1)sc1ncnc(Nc3cc4ccnn4cc3Cl)c21
Show InChI InChI=1S/C22H23ClN6O2S/c1-2-28(7-8-30)22(31)13-3-4-15-18(9-13)32-21-19(15)20(24-12-25-21)27-17-10-14-5-6-26-29(14)11-16(17)23/h5-6,10-13,30H,2-4,7-9H2,1H3,(H,24,25,27)/t13-/m0/s1
PDB

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n/an/a 6n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
A recombinant fusion protein of Glutathione-S-Transferase (GST, N-terminally) and human full-length MKNK1 (amino acids 1-424 and T344D of accession n...


US Patent US10487092 (2019)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1)


(Homo sapiens (Human))
BDBM420248
PNG
((7S)-4-[(6-Methoxypyrazolo[1,5-a]pyridin-5-yl)amin...)
Show SMILES COc1cn2nccc2cc1Nc1ncnc2sc3C[C@H](CCc3c12)C(=O)N(C)CCC(F)(F)F
Show InChI InChI=1S/C23H23F3N6O2S/c1-31(8-6-23(24,25)26)22(33)13-3-4-15-18(9-13)35-21-19(15)20(27-12-28-21)30-16-10-14-5-7-29-32(14)11-17(16)34-2/h5,7,10-13H,3-4,6,8-9H2,1-2H3,(H,27,28,30)/t13-/m0/s1
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n/an/a 7n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
A recombinant fusion protein of Glutathione-S-Transferase (GST, N-terminally) and human full-length MKNK1 (amino acids 1-424 and T344D of accession n...


US Patent US10487092 (2019)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1)


(Homo sapiens (Human))
BDBM420210
PNG
((7S)óN-(3-Fluorophenyl)-4-[(6-methoxypyrazolo[1,5-...)
Show SMILES COc1cn2nccc2cc1Nc1ncnc2sc3C[C@H](CCc3c12)C(=O)Nc1cccc(F)c1
Show InChI InChI=1S/C25H21FN6O2S/c1-34-20-12-32-17(7-8-29-32)11-19(20)31-23-22-18-6-5-14(9-21(18)35-25(22)28-13-27-23)24(33)30-16-4-2-3-15(26)10-16/h2-4,7-8,10-14H,5-6,9H2,1H3,(H,30,33)(H,27,28,31)/t14-/m0/s1
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n/an/a 7n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
A recombinant fusion protein of Glutathione-S-Transferase (GST, N-terminally) and human full-length MKNK1 (amino acids 1-424 and T344D of accession n...


US Patent US10487092 (2019)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1)


(Homo sapiens (Human))
BDBM420175
PNG
((7S)-4-[(6-Chloropyrazolo[1,5-a]pyridin-5-yl)amino...)
Show SMILES CCN(CCOC)C(=O)[C@H]1CCc2c(C1)sc1ncnc(Nc3cc4ccnn4cc3Cl)c21
Show InChI InChI=1S/C23H25ClN6O2S/c1-3-29(8-9-32-2)23(31)14-4-5-16-19(10-14)33-22-20(16)21(25-13-26-22)28-18-11-15-6-7-27-30(15)12-17(18)24/h6-7,11-14H,3-5,8-10H2,1-2H3,(H,25,26,28)/t14-/m0/s1
PDB

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n/an/a 7n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
A recombinant fusion protein of Glutathione-S-Transferase (GST, N-terminally) and human full-length MKNK1 (amino acids 1-424 and T344D of accession n...


US Patent US10487092 (2019)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1)


(Homo sapiens (Human))
BDBM420189
PNG
((7S)-4-[(6-Chloropyrazolo[1,5-a]pyridin-5-yl)amino...)
Show SMILES C[C@H]1COCCN1C(=O)[C@H]1CCc2c(C1)sc1ncnc(Nc3cc4ccnn4cc3Cl)c21
Show InChI InChI=1S/C23H23ClN6O2S/c1-13-11-32-7-6-29(13)23(31)14-2-3-16-19(8-14)33-22-20(16)21(25-12-26-22)28-18-9-15-4-5-27-30(15)10-17(18)24/h4-5,9-10,12-14H,2-3,6-8,11H2,1H3,(H,25,26,28)/t13-,14-/m0/s1
PDB

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n/an/a 7n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
A recombinant fusion protein of Glutathione-S-Transferase (GST, N-terminally) and human full-length MKNK1 (amino acids 1-424 and T344D of accession n...


US Patent US10487092 (2019)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1)


(Homo sapiens (Human))
BDBM420143
PNG
(1-((7S)-4-[(6-Chloropyrazolo[1,5-a]pyridin-5-yl)am...)
Show SMILES Clc1cn2nccc2cc1Nc1ncnc2sc3C[C@H](CCc3c12)C(=O)N1CC(C1)C#N
Show InChI InChI=1S/C22H18ClN7OS/c23-16-10-30-14(3-4-27-30)6-17(16)28-20-19-15-2-1-13(22(31)29-8-12(7-24)9-29)5-18(15)32-21(19)26-11-25-20/h3-4,6,10-13H,1-2,5,8-9H2,(H,25,26,28)/t13-/m0/s1
PDB

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n/an/a 7n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
A recombinant fusion protein of Glutathione-S-Transferase (GST, N-terminally) and human full-length MKNK1 (amino acids 1-424 and T344D of accession n...


US Patent US10487092 (2019)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1)


(Homo sapiens (Human))
BDBM420100
PNG
(US10487092, Example 14 | [(3R,5R)-3,5-Dimethylmorp...)
Show SMILES C[C@@H]1COC[C@@H](C)N1C(=O)[C@H]1CCc2c(C1)sc1ncnc(Nc3ccn4nccc4c3)c21
Show InChI InChI=1S/C24H26N6O2S/c1-14-11-32-12-15(2)30(14)24(31)16-3-4-19-20(9-16)33-23-21(19)22(25-13-26-23)28-17-6-8-29-18(10-17)5-7-27-29/h5-8,10,13-16H,3-4,9,11-12H2,1-2H3,(H,25,26,28)/t14-,15-,16+/m1/s1
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n/an/a 7n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
A recombinant fusion protein of Glutathione-S-Transferase (GST, N-terminally) and human full-length MKNK1 (amino acids 1-424 and T344D of accession n...


US Patent US10487092 (2019)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1)


(Homo sapiens (Human))
BDBM420145
PNG
((7S)-4-[(6-Chloropyrazolo[1,5-a]pyridin-5-yl)amino...)
Show SMILES CC1(O)CN(C1)C(=O)[C@H]1CCc2c(C1)sc1ncnc(Nc3cc4ccnn4cc3Cl)c21
Show InChI InChI=1S/C22H21ClN6O2S/c1-22(31)9-28(10-22)21(30)12-2-3-14-17(6-12)32-20-18(14)19(24-11-25-20)27-16-7-13-4-5-26-29(13)8-15(16)23/h4-5,7-8,11-12,31H,2-3,6,9-10H2,1H3,(H,24,25,27)/t12-/m0/s1
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n/an/a 8n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
A recombinant fusion protein of Glutathione-S-Transferase (GST, N-terminally) and human full-length MKNK1 (amino acids 1-424 and T344D of accession n...


US Patent US10487092 (2019)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1)


(Homo sapiens (Human))
BDBM420203
PNG
((7S)óN-(4-Fluorophenyl)-4-[(6-methoxypyrazolo[1,5-...)
Show SMILES COc1cn2nccc2nc1Nc1ncnc2sc3C[C@H](CCc3c12)C(=O)Nc1ccc(F)cc1
Show InChI InChI=1S/C24H20FN7O2S/c1-34-17-11-32-19(8-9-28-32)30-21(17)31-22-20-16-7-2-13(10-18(16)35-24(20)27-12-26-22)23(33)29-15-5-3-14(25)4-6-15/h3-6,8-9,11-13H,2,7,10H2,1H3,(H,29,33)(H,26,27,30,31)/t13-/m0/s1
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n/an/a 8n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
A recombinant fusion protein of Glutathione-S-Transferase (GST, N-terminally) and human full-length MKNK1 (amino acids 1-424 and T344D of accession n...


US Patent US10487092 (2019)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1)


(Homo sapiens (Human))
BDBM420146
PNG
((7S)-4-[(6-Chloropyrazolo[1,5-a]pyridin-5-yl)amino...)
Show SMILES CN(C)CCN(C)C(=O)[C@H]1CCc2c(C1)sc1ncnc(Nc3cc4ccnn4cc3Cl)c21
Show InChI InChI=1S/C23H26ClN7OS/c1-29(2)8-9-30(3)23(32)14-4-5-16-19(10-14)33-22-20(16)21(25-13-26-22)28-18-11-15-6-7-27-31(15)12-17(18)24/h6-7,11-14H,4-5,8-10H2,1-3H3,(H,25,26,28)/t14-/m0/s1
PDB

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n/an/a 9n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
A recombinant fusion protein of Glutathione-S-Transferase (GST, N-terminally) and human full-length MKNK1 (amino acids 1-424 and T344D of accession n...


US Patent US10487092 (2019)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1)


(Homo sapiens (Human))
BDBM420165
PNG
((7S)-4-[(6-Chloropyrazolo[1,5-a]pyridin-5-yl)amino...)
Show SMILES C[C@H]1CN(C[C@@H](C)O1)C(=O)[C@H]1CCc2c(C1)sc1ncnc(Nc3cc4ccnn4cc3Cl)c21
Show InChI InChI=1S/C24H25ClN6O2S/c1-13-9-30(10-14(2)33-13)24(32)15-3-4-17-20(7-15)34-23-21(17)22(26-12-27-23)29-19-8-16-5-6-28-31(16)11-18(19)25/h5-6,8,11-15H,3-4,7,9-10H2,1-2H3,(H,26,27,29)/t13-,14+,15-/m0/s1
PDB

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n/an/a 10n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
A recombinant fusion protein of Glutathione-S-Transferase (GST, N-terminally) and human full-length MKNK1 (amino acids 1-424 and T344D of accession n...


US Patent US10487092 (2019)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1)


(Homo sapiens (Human))
BDBM420147
PNG
((7S)-4-[(6-Chloropyrazolo[1,5-a]pyridin-5-yl)amino...)
Show SMILES CN(C)C1CN(C1)C(=O)[C@H]1CCc2c(C1)sc1ncnc(Nc3cc4ccnn4cc3Cl)c21
Show InChI InChI=1S/C23H24ClN7OS/c1-29(2)15-9-30(10-15)23(32)13-3-4-16-19(7-13)33-22-20(16)21(25-12-26-22)28-18-8-14-5-6-27-31(14)11-17(18)24/h5-6,8,11-13,15H,3-4,7,9-10H2,1-2H3,(H,25,26,28)/t13-/m0/s1
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n/an/a 11n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
A recombinant fusion protein of Glutathione-S-Transferase (GST, N-terminally) and human full-length MKNK1 (amino acids 1-424 and T344D of accession n...


US Patent US10487092 (2019)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1)


(Homo sapiens (Human))
BDBM420134
PNG
(US10487092, Example 41 | [(3S)-3-(Dimethylamino)py...)
Show SMILES CN(C)[C@H]1CCN(C1)C(=O)[C@H]1CCc2c(C1)sc1ncnc(Nc3ccn4nccc4c3)c21
Show InChI InChI=1S/C24H27N7OS/c1-29(2)18-7-9-30(13-18)24(32)15-3-4-19-20(11-15)33-23-21(19)22(25-14-26-23)28-16-6-10-31-17(12-16)5-8-27-31/h5-6,8,10,12,14-15,18H,3-4,7,9,11,13H2,1-2H3,(H,25,26,28)/t15-,18-/m0/s1
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n/an/a 11n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
A recombinant fusion protein of Glutathione-S-Transferase (GST, N-terminally) and human full-length MKNK1 (amino acids 1-424 and T344D of accession n...


US Patent US10487092 (2019)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1)


(Homo sapiens (Human))
BDBM420135
PNG
(US10487092, Example 42 | [(1R,4R)-5-Methyl-2,5-dia...)
Show SMILES CN1C[C@H]2C[C@@H]1CN2C(=O)[C@H]1CCc2c(C1)sc1ncnc(Nc3ccn4nccc4c3)c21
Show InChI InChI=1S/C24H25N7OS/c1-29-11-18-10-17(29)12-30(18)24(32)14-2-3-19-20(8-14)33-23-21(19)22(25-13-26-23)28-15-5-7-31-16(9-15)4-6-27-31/h4-7,9,13-14,17-18H,2-3,8,10-12H2,1H3,(H,25,26,28)/t14-,17+,18+/m0/s1
PDB

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n/an/a 11n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
A recombinant fusion protein of Glutathione-S-Transferase (GST, N-terminally) and human full-length MKNK1 (amino acids 1-424 and T344D of accession n...


US Patent US10487092 (2019)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1)


(Homo sapiens (Human))
BDBM420139
PNG
((7S)-4-[(6-Chloropyrazolo[1,5-a]pyridin-5-yl)amino...)
Show SMILES CCN(C)C(=O)[C@H]1CCc2c(C1)sc1ncnc(Nc3cc4ccnn4cc3Cl)c21
Show InChI InChI=1S/C21H21ClN6OS/c1-3-27(2)21(29)12-4-5-14-17(8-12)30-20-18(14)19(23-11-24-20)26-16-9-13-6-7-25-28(13)10-15(16)22/h6-7,9-12H,3-5,8H2,1-2H3,(H,23,24,26)/t12-/m0/s1
PDB

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n/an/a 11n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
A recombinant fusion protein of Glutathione-S-Transferase (GST, N-terminally) and human full-length MKNK1 (amino acids 1-424 and T344D of accession n...


US Patent US10487092 (2019)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1)


(Homo sapiens (Human))
BDBM420138
PNG
((7S)-4-[(6-Chloropyrazolo[1,5-a]pyridin-5-yl)amino...)
Show SMILES CN(C)C(=O)[C@H]1CCc2c(C1)sc1ncnc(Nc3cc4ccnn4cc3Cl)c21
Show InChI InChI=1S/C20H19ClN6OS/c1-26(2)20(28)11-3-4-13-16(7-11)29-19-17(13)18(22-10-23-19)25-15-8-12-5-6-24-27(12)9-14(15)21/h5-6,8-11H,3-4,7H2,1-2H3,(H,22,23,25)/t11-/m0/s1
PDB

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n/an/a 12n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
A recombinant fusion protein of Glutathione-S-Transferase (GST, N-terminally) and human full-length MKNK1 (amino acids 1-424 and T344D of accession n...


US Patent US10487092 (2019)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1)


(Homo sapiens (Human))
BDBM420085
PNG
(US10487092, Example 6 | [(3R)-3-(Dimethylamino)pyr...)
Show SMILES CN(C)[C@@H]1CCN(C1)C(=O)[C@H]1CCc2c(C1)sc1ncnc(Nc3ccn4nccc4c3)c21
Show InChI InChI=1S/C24H27N7OS/c1-29(2)18-7-9-30(13-18)24(32)15-3-4-19-20(11-15)33-23-21(19)22(25-14-26-23)28-16-6-10-31-17(12-16)5-8-27-31/h5-6,8,10,12,14-15,18H,3-4,7,9,11,13H2,1-2H3,(H,25,26,28)/t15-,18+/m0/s1
PDB

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n/an/a 12n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
A recombinant fusion protein of Glutathione-S-Transferase (GST, N-terminally) and human full-length MKNK1 (amino acids 1-424 and T344D of accession n...


US Patent US10487092 (2019)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1)


(Homo sapiens (Human))
BDBM420176
PNG
((7S)-4-[(6-Chloropyrazolo[1,5-a]pyridin-5-yl)amino...)
Show SMILES COCCN(CCOC)C(=O)[C@H]1CCc2c(C1)sc1ncnc(Nc3cc4ccnn4cc3Cl)c21
Show InChI InChI=1S/C24H27ClN6O3S/c1-33-9-7-30(8-10-34-2)24(32)15-3-4-17-20(11-15)35-23-21(17)22(26-14-27-23)29-19-12-16-5-6-28-31(16)13-18(19)25/h5-6,12-15H,3-4,7-11H2,1-2H3,(H,26,27,29)/t15-/m0/s1
PDB

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n/an/a 12n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
A recombinant fusion protein of Glutathione-S-Transferase (GST, N-terminally) and human full-length MKNK1 (amino acids 1-424 and T344D of accession n...


US Patent US10487092 (2019)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1)


(Homo sapiens (Human))
BDBM420152
PNG
((7S)-4-[(6-Chloropyrazolo[1,5-a]pyridin-5-yl)amino...)
Show SMILES CC(C)N(C)C(=O)[C@H]1CCc2c(C1)sc1ncnc(Nc3cc4ccnn4cc3Cl)c21
Show InChI InChI=1S/C22H23ClN6OS/c1-12(2)28(3)22(30)13-4-5-15-18(8-13)31-21-19(15)20(24-11-25-21)27-17-9-14-6-7-26-29(14)10-16(17)23/h6-7,9-13H,4-5,8H2,1-3H3,(H,24,25,27)/t13-/m0/s1
PDB

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n/an/a 12n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
A recombinant fusion protein of Glutathione-S-Transferase (GST, N-terminally) and human full-length MKNK1 (amino acids 1-424 and T344D of accession n...


US Patent US10487092 (2019)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1)


(Homo sapiens (Human))
BDBM420118
PNG
((7S)óN-[3-(Dimethylamino)propyl]-N-methyl-4-(pyraz...)
Show SMILES CN(C)CCCN(C)C(=O)[C@H]1CCc2c(C1)sc1ncnc(Nc3ccn4nccc4c3)c21
Show InChI InChI=1S/C24H29N7OS/c1-29(2)10-4-11-30(3)24(32)16-5-6-19-20(13-16)33-23-21(19)22(25-15-26-23)28-17-8-12-31-18(14-17)7-9-27-31/h7-9,12,14-16H,4-6,10-11,13H2,1-3H3,(H,25,26,28)/t16-/m0/s1
PDB

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n/an/a 13n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
A recombinant fusion protein of Glutathione-S-Transferase (GST, N-terminally) and human full-length MKNK1 (amino acids 1-424 and T344D of accession n...


US Patent US10487092 (2019)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1)


(Homo sapiens (Human))
BDBM420159
PNG
((7S)-4-[(6-Chloropyrazolo[1,5-a]pyridin-5-yl)amino...)
Show SMILES CN(C)C1CCN(CC1)C(=O)[C@H]1CCc2c(C1)sc1ncnc(Nc3cc4ccnn4cc3Cl)c21
Show InChI InChI=1S/C25H28ClN7OS/c1-31(2)16-6-9-32(10-7-16)25(34)15-3-4-18-21(11-15)35-24-22(18)23(27-14-28-24)30-20-12-17-5-8-29-33(17)13-19(20)26/h5,8,12-16H,3-4,6-7,9-11H2,1-2H3,(H,27,28,30)/t15-/m0/s1
PDB

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n/an/a 13n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
A recombinant fusion protein of Glutathione-S-Transferase (GST, N-terminally) and human full-length MKNK1 (amino acids 1-424 and T344D of accession n...


US Patent US10487092 (2019)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1)


(Homo sapiens (Human))
BDBM420116
PNG
(US10487092, Example 25 | US10487092, Example 39 | ...)
Show SMILES CN(CCNC(=O)OC(C)(C)C)C(=O)[C@H]1CCc2c(C1)sc1ncnc(Nc3ccn4nccc4c3)c21
Show InChI InChI=1S/C26H31N7O3S/c1-26(2,3)36-25(35)27-10-12-32(4)24(34)16-5-6-19-20(13-16)37-23-21(19)22(28-15-29-23)31-17-8-11-33-18(14-17)7-9-30-33/h7-9,11,14-16H,5-6,10,12-13H2,1-4H3,(H,27,35)(H,28,29,31)/t16-/m0/s1
PDB

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n/an/a 13n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
A recombinant fusion protein of Glutathione-S-Transferase (GST, N-terminally) and human full-length MKNK1 (amino acids 1-424 and T344D of accession n...


US Patent US10487092 (2019)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1)


(Homo sapiens (Human))
BDBM420183
PNG
((7S)-4-[(6-Chloropyrazolo[1,5-a]pyridin-5-yl)amino...)
Show SMILES CN1C[C@@H]2C[C@H]1CN2C(=O)[C@H]1CCc2c(C1)sc1ncnc(Nc3cc4ccnn4cc3Cl)c21
Show InChI InChI=1S/C24H24ClN7OS/c1-30-9-16-7-15(30)10-31(16)24(33)13-2-3-17-20(6-13)34-23-21(17)22(26-12-27-23)29-19-8-14-4-5-28-32(14)11-18(19)25/h4-5,8,11-13,15-16H,2-3,6-7,9-10H2,1H3,(H,26,27,29)/t13-,15-,16-/m0/s1
PDB

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n/an/a 14n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
A recombinant fusion protein of Glutathione-S-Transferase (GST, N-terminally) and human full-length MKNK1 (amino acids 1-424 and T344D of accession n...


US Patent US10487092 (2019)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1)


(Homo sapiens (Human))
BDBM420117
PNG
((7S)óN-[2-(Dimethylamino)-2-oxoethyl]-N-methyl-4-(...)
Show SMILES CN(C)C(=O)CN(C)C(=O)[C@H]1CCc2c(C1)sc1ncnc(Nc3ccn4nccc4c3)c21
Show InChI InChI=1S/C23H25N7O2S/c1-28(2)19(31)12-29(3)23(32)14-4-5-17-18(10-14)33-22-20(17)21(24-13-25-22)27-15-7-9-30-16(11-15)6-8-26-30/h6-9,11,13-14H,4-5,10,12H2,1-3H3,(H,24,25,27)/t14-/m0/s1
PDB

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n/an/a 14n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
A recombinant fusion protein of Glutathione-S-Transferase (GST, N-terminally) and human full-length MKNK1 (amino acids 1-424 and T344D of accession n...


US Patent US10487092 (2019)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1)


(Homo sapiens (Human))
BDBM420164
PNG
((7S)4-[(6-Chloropyrazolo[1,5-a]pyridin-5-yl)amino]...)
Show SMILES CN(C)CCCN(CCO)C(=O)[C@H]1CCc2c(C1)sc1ncnc(Nc3cc4ccnn4cc3Cl)c21
Show InChI InChI=1S/C25H30ClN7O2S/c1-31(2)8-3-9-32(10-11-34)25(35)16-4-5-18-21(12-16)36-24-22(18)23(27-15-28-24)30-20-13-17-6-7-29-33(17)14-19(20)26/h6-7,13-16,34H,3-5,8-12H2,1-2H3,(H,27,28,30)/t16-/m0/s1
PDB

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n/an/a 15n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
A recombinant fusion protein of Glutathione-S-Transferase (GST, N-terminally) and human full-length MKNK1 (amino acids 1-424 and T344D of accession n...


US Patent US10487092 (2019)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1)


(Homo sapiens (Human))
BDBM420142
PNG
((7S)óN-Butyl-4-[(6-chloropyrazolo[1,5-a]pyridin-5-...)
Show SMILES CCCCN(C)C(=O)[C@H]1CCc2c(C1)sc1ncnc(Nc3cc4ccnn4cc3Cl)c21
Show InChI InChI=1S/C23H25ClN6OS/c1-3-4-9-29(2)23(31)14-5-6-16-19(10-14)32-22-20(16)21(25-13-26-22)28-18-11-15-7-8-27-30(15)12-17(18)24/h7-8,11-14H,3-6,9-10H2,1-2H3,(H,25,26,28)/t14-/m0/s1
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n/an/a 15n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
A recombinant fusion protein of Glutathione-S-Transferase (GST, N-terminally) and human full-length MKNK1 (amino acids 1-424 and T344D of accession n...


US Patent US10487092 (2019)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1)


(Homo sapiens (Human))
BDBM420123
PNG
((3-Hydroxy-3-methylazetidin-1-yl)[(7S)-4-(pyrazolo...)
Show SMILES CC1(O)CN(C1)C(=O)[C@H]1CCc2c(C1)sc1ncnc(Nc3ccn4nccc4c3)c21
Show InChI InChI=1S/C22H22N6O2S/c1-22(30)10-27(11-22)21(29)13-2-3-16-17(8-13)31-20-18(16)19(23-12-24-20)26-14-5-7-28-15(9-14)4-6-25-28/h4-7,9,12-13,30H,2-3,8,10-11H2,1H3,(H,23,24,26)/t13-/m0/s1
PDB

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n/an/a 16n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
A recombinant fusion protein of Glutathione-S-Transferase (GST, N-terminally) and human full-length MKNK1 (amino acids 1-424 and T344D of accession n...


US Patent US10487092 (2019)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1)


(Homo sapiens (Human))
BDBM420098
PNG
(US10487092, Example 13 | [(3R,5S)-3,5-Dimethylmorp...)
Show SMILES C[C@H]1COC[C@@H](C)N1C(=O)[C@H]1CCc2c(C1)sc1ncnc(Nc3ccn4nccc4c3)c21
Show InChI InChI=1S/C24H26N6O2S/c1-14-11-32-12-15(2)30(14)24(31)16-3-4-19-20(9-16)33-23-21(19)22(25-13-26-23)28-17-6-8-29-18(10-17)5-7-27-29/h5-8,10,13-16H,3-4,9,11-12H2,1-2H3,(H,25,26,28)/t14-,15+,16-/m0/s1
PDB

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n/an/a 17n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
A recombinant fusion protein of Glutathione-S-Transferase (GST, N-terminally) and human full-length MKNK1 (amino acids 1-424 and T344D of accession n...


US Patent US10487092 (2019)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1)


(Homo sapiens (Human))
BDBM420149
PNG
((7S)-4-[(6-Chloropyrazolo[1,5-a]pyridin-5-yl)amino...)
Show SMILES CN(CCO)C(=O)[C@H]1CCc2c(C1)sc1ncnc(Nc3cc4ccnn4cc3Cl)c21
Show InChI InChI=1S/C21H21ClN6O2S/c1-27(6-7-29)21(30)12-2-3-14-17(8-12)31-20-18(14)19(23-11-24-20)26-16-9-13-4-5-25-28(13)10-15(16)22/h4-5,9-12,29H,2-3,6-8H2,1H3,(H,23,24,26)/t12-/m0/s1
PDB

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n/an/a 18n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
A recombinant fusion protein of Glutathione-S-Transferase (GST, N-terminally) and human full-length MKNK1 (amino acids 1-424 and T344D of accession n...


US Patent US10487092 (2019)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1)


(Homo sapiens (Human))
BDBM420140
PNG
((7S)-4-[(6-Chloropyrazolo[1,5-a]pyridin-5-yl)amino...)
Show SMILES CN(CC(F)F)C(=O)[C@H]1CCc2c(C1)sc1ncnc(Nc3cc4ccnn4cc3Cl)c21
Show InChI InChI=1S/C21H19ClF2N6OS/c1-29(9-17(23)24)21(31)11-2-3-13-16(6-11)32-20-18(13)19(25-10-26-20)28-15-7-12-4-5-27-30(12)8-14(15)22/h4-5,7-8,10-11,17H,2-3,6,9H2,1H3,(H,25,26,28)/t11-/m0/s1
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n/an/a 18n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
A recombinant fusion protein of Glutathione-S-Transferase (GST, N-terminally) and human full-length MKNK1 (amino acids 1-424 and T344D of accession n...


US Patent US10487092 (2019)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1)


(Homo sapiens (Human))
BDBM420158
PNG
((7S)-4-[(6-Chloropyrazolo[1,5-a]pyridin-5-yl)amino...)
Show SMILES O[C@H]1CN(C[C@@H]1O)C(=O)[C@H]1CCc2c(C1)sc1ncnc(Nc3cc4ccnn4cc3Cl)c21
Show InChI InChI=1S/C22H21ClN6O3S/c23-14-7-29-12(3-4-26-29)6-15(14)27-20-19-13-2-1-11(5-18(13)33-21(19)25-10-24-20)22(32)28-8-16(30)17(31)9-28/h3-4,6-7,10-11,16-17,30-31H,1-2,5,8-9H2,(H,24,25,27)/t11-,16-,17-/m0/s1
PDB

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n/an/a 18n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
A recombinant fusion protein of Glutathione-S-Transferase (GST, N-terminally) and human full-length MKNK1 (amino acids 1-424 and T344D of accession n...


US Patent US10487092 (2019)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1)


(Homo sapiens (Human))
BDBM420119
PNG
(US10487092, Example 28 | [3-(Dimethylamino)azetidi...)
Show SMILES CN(C)C1CN(C1)C(=O)[C@H]1CCc2c(C1)sc1ncnc(Nc3ccn4nccc4c3)c21
Show InChI InChI=1S/C23H25N7OS/c1-28(2)17-11-29(12-17)23(31)14-3-4-18-19(9-14)32-22-20(18)21(24-13-25-22)27-15-6-8-30-16(10-15)5-7-26-30/h5-8,10,13-14,17H,3-4,9,11-12H2,1-2H3,(H,24,25,27)/t14-/m0/s1
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n/an/a 19n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
A recombinant fusion protein of Glutathione-S-Transferase (GST, N-terminally) and human full-length MKNK1 (amino acids 1-424 and T344D of accession n...


US Patent US10487092 (2019)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1)


(Homo sapiens (Human))
BDBM420102
PNG
((7S)óN-Isopropyl-N-methyl-4-(pyrazolo[1,5-a]pyridi...)
Show SMILES CC(C)N(C)C(=O)[C@H]1CCc2c(C1)sc1ncnc(Nc3ccn4nccc4c3)c21
Show InChI InChI=1S/C22H24N6OS/c1-13(2)27(3)22(29)14-4-5-17-18(10-14)30-21-19(17)20(23-12-24-21)26-15-7-9-28-16(11-15)6-8-25-28/h6-9,11-14H,4-5,10H2,1-3H3,(H,23,24,26)/t14-/m0/s1
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n/an/a 19n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
A recombinant fusion protein of Glutathione-S-Transferase (GST, N-terminally) and human full-length MKNK1 (amino acids 1-424 and T344D of accession n...


US Patent US10487092 (2019)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1)


(Homo sapiens (Human))
BDBM420106
PNG
((7S)óN-(2,2-Difluoroethyl)-N-methyl-4-(pyrazolo[1,...)
Show SMILES CN(CC(F)F)C(=O)[C@H]1CCc2c(C1)sc1ncnc(Nc3ccn4nccc4c3)c21
Show InChI InChI=1S/C21H20F2N6OS/c1-28(10-17(22)23)21(30)12-2-3-15-16(8-12)31-20-18(15)19(24-11-25-20)27-13-5-7-29-14(9-13)4-6-26-29/h4-7,9,11-12,17H,2-3,8,10H2,1H3,(H,24,25,27)/t12-/m0/s1
PDB

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n/an/a 19n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
A recombinant fusion protein of Glutathione-S-Transferase (GST, N-terminally) and human full-length MKNK1 (amino acids 1-424 and T344D of accession n...


US Patent US10487092 (2019)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1)


(Homo sapiens (Human))
BDBM420110
PNG
((7S)óN-Ethyl-N-(2-hydroxyethyl)-4-(pyrazolo[1,5-a]...)
Show SMILES CCN(CCO)C(=O)[C@H]1CCc2c(C1)sc1ncnc(Nc3ccn4nccc4c3)c21
Show InChI InChI=1S/C22H24N6O2S/c1-2-27(9-10-29)22(30)14-3-4-17-18(11-14)31-21-19(17)20(23-13-24-21)26-15-6-8-28-16(12-15)5-7-25-28/h5-8,12-14,29H,2-4,9-11H2,1H3,(H,23,24,26)/t14-/m0/s1
PDB

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n/an/a 19n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
A recombinant fusion protein of Glutathione-S-Transferase (GST, N-terminally) and human full-length MKNK1 (amino acids 1-424 and T344D of accession n...


US Patent US10487092 (2019)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1)


(Homo sapiens (Human))
BDBM420115
PNG
((3-Hydroxyazetidin-1-yl)[(7S)-4-(pyrazolo[1,5-a]py...)
Show SMILES OC1CN(C1)C(=O)[C@H]1CCc2c(C1)sc1ncnc(Nc3ccn4nccc4c3)c21
Show InChI InChI=1S/C21H20N6O2S/c28-15-9-26(10-15)21(29)12-1-2-16-17(7-12)30-20-18(16)19(22-11-23-20)25-13-4-6-27-14(8-13)3-5-24-27/h3-6,8,11-12,15,28H,1-2,7,9-10H2,(H,22,23,25)/t12-/m0/s1
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n/an/a 20n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
A recombinant fusion protein of Glutathione-S-Transferase (GST, N-terminally) and human full-length MKNK1 (amino acids 1-424 and T344D of accession n...


US Patent US10487092 (2019)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1)


(Homo sapiens (Human))
BDBM420121
PNG
((4-Methylpiperazin-1-yl)[(7S)-4-(pyrazolo[1,5-a]py...)
Show SMILES CN1CCN(CC1)C(=O)[C@H]1CCc2c(C1)sc1ncnc(Nc3ccn4nccc4c3)c21
Show InChI InChI=1S/C23H25N7OS/c1-28-8-10-29(11-9-28)23(31)15-2-3-18-19(12-15)32-22-20(18)21(24-14-25-22)27-16-5-7-30-17(13-16)4-6-26-30/h4-7,13-15H,2-3,8-12H2,1H3,(H,24,25,27)/t15-/m0/s1
PDB

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n/an/a 20n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
A recombinant fusion protein of Glutathione-S-Transferase (GST, N-terminally) and human full-length MKNK1 (amino acids 1-424 and T344D of accession n...


US Patent US10487092 (2019)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1)


(Homo sapiens (Human))
BDBM420080
PNG
(US10487092, Example 5 | [(2R,6S)-2,6-Dimethylmorph...)
Show SMILES C[C@H]1CN(C[C@@H](C)O1)C(=O)[C@H]1CCc2c(C1)sc1ncnc(Nc3ccn4nccc4c3)c21
Show InChI InChI=1S/C24H26N6O2S/c1-14-11-29(12-15(2)32-14)24(31)16-3-4-19-20(9-16)33-23-21(19)22(25-13-26-23)28-17-6-8-30-18(10-17)5-7-27-30/h5-8,10,13-16H,3-4,9,11-12H2,1-2H3,(H,25,26,28)/t14-,15+,16-/m0/s1
PDB

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n/an/a 21n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
A recombinant fusion protein of Glutathione-S-Transferase (GST, N-terminally) and human full-length MKNK1 (amino acids 1-424 and T344D of accession n...


US Patent US10487092 (2019)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1)


(Homo sapiens (Human))
BDBM420079
PNG
((7S)óN-[2-(Dimethylamino)ethyl]-N-methyl-4-(pyrazo...)
Show SMILES CN(C)CCN(C)C(=O)[C@H]1CCc2c(C1)sc1ncnc(Nc3ccn4nccc4c3)c21
Show InChI InChI=1S/C23H27N7OS/c1-28(2)10-11-29(3)23(31)15-4-5-18-19(12-15)32-22-20(18)21(24-14-25-22)27-16-7-9-30-17(13-16)6-8-26-30/h6-9,13-15H,4-5,10-12H2,1-3H3,(H,24,25,27)/t15-/m0/s1
PDB

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n/an/a 21n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
A recombinant fusion protein of Glutathione-S-Transferase (GST, N-terminally) and human full-length MKNK1 (amino acids 1-424 and T344D of accession n...


US Patent US10487092 (2019)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1)


(Homo sapiens (Human))
BDBM420191
PNG
((7S)-4-[(6-Chloropyrazolo[1,5-a]pyridin-5-yl)amino...)
Show SMILES C[C@@H]1COCCN1C(=O)[C@H]1CCc2c(C1)sc1ncnc(Nc3cc4ccnn4cc3Cl)c21
Show InChI InChI=1S/C23H23ClN6O2S/c1-13-11-32-7-6-29(13)23(31)14-2-3-16-19(8-14)33-22-20(16)21(25-12-26-22)28-18-9-15-4-5-27-30(15)10-17(18)24/h4-5,9-10,12-14H,2-3,6-8,11H2,1H3,(H,25,26,28)/t13-,14+/m1/s1
PDB

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n/an/a 21n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
A recombinant fusion protein of Glutathione-S-Transferase (GST, N-terminally) and human full-length MKNK1 (amino acids 1-424 and T344D of accession n...


US Patent US10487092 (2019)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1)


(Homo sapiens (Human))
BDBM420108
PNG
((7S)óN-(2-Hydroxy-2-methylpropyl)-N-methyl-4-(pyra...)
Show SMILES CN(CC(C)(C)O)C(=O)[C@H]1CCc2c(C1)sc1ncnc(Nc3ccn4nccc4c3)c21
Show InChI InChI=1S/C23H26N6O2S/c1-23(2,31)12-28(3)22(30)14-4-5-17-18(10-14)32-21-19(17)20(24-13-25-21)27-15-7-9-29-16(11-15)6-8-26-29/h6-9,11,13-14,31H,4-5,10,12H2,1-3H3,(H,24,25,27)/t14-/m0/s1
PDB

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n/an/a 21n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
A recombinant fusion protein of Glutathione-S-Transferase (GST, N-terminally) and human full-length MKNK1 (amino acids 1-424 and T344D of accession n...


US Patent US10487092 (2019)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1)


(Homo sapiens (Human))
BDBM420112
PNG
(1-{[(7S)-4-(Pyrazolo[1,5-a]pyridin-5-ylamino)-5,6,...)
Show SMILES O=C([C@H]1CCc2c(C1)sc1ncnc(Nc3ccn4nccc4c3)c21)N1CC(C1)C#N
Show InChI InChI=1S/C22H19N7OS/c23-9-13-10-28(11-13)22(30)14-1-2-17-18(7-14)31-21-19(17)20(24-12-25-21)27-15-4-6-29-16(8-15)3-5-26-29/h3-6,8,12-14H,1-2,7,10-11H2,(H,24,25,27)/t14-/m0/s1
PDB

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n/an/a 21n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
A recombinant fusion protein of Glutathione-S-Transferase (GST, N-terminally) and human full-length MKNK1 (amino acids 1-424 and T344D of accession n...


US Patent US10487092 (2019)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1)


(Homo sapiens (Human))
BDBM420186
PNG
((7S)-4-[(6-Chloropyrazolo[1,5-a]pyridin-5-yl)amino...)
Show SMILES Clc1cn2nccc2cc1Nc1ncnc2sc3C[C@H](CCc3c12)C(=O)N1C[C@@H]2C[C@H]1CO2
Show InChI InChI=1S/C23H21ClN6O2S/c24-17-9-30-13(3-4-27-30)7-18(17)28-21-20-16-2-1-12(5-19(16)33-22(20)26-11-25-21)23(31)29-8-15-6-14(29)10-32-15/h3-4,7,9,11-12,14-15H,1-2,5-6,8,10H2,(H,25,26,28)/t12-,14-,15-/m0/s1
PDB

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n/an/a 22n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
A recombinant fusion protein of Glutathione-S-Transferase (GST, N-terminally) and human full-length MKNK1 (amino acids 1-424 and T344D of accession n...


US Patent US10487092 (2019)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1)


(Homo sapiens (Human))
BDBM420114
PNG
((3,3-Difluoroazetidin-1-yl)[(7S)-4-(pyrazolo[1,5-a...)
Show SMILES FC1(F)CN(C1)C(=O)[C@H]1CCc2c(C1)sc1ncnc(Nc3ccn4nccc4c3)c21
Show InChI InChI=1S/C21H18F2N6OS/c22-21(23)9-28(10-21)20(30)12-1-2-15-16(7-12)31-19-17(15)18(24-11-25-19)27-13-4-6-29-14(8-13)3-5-26-29/h3-6,8,11-12H,1-2,7,9-10H2,(H,24,25,27)/t12-/m0/s1
PDB

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n/an/a 23n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
A recombinant fusion protein of Glutathione-S-Transferase (GST, N-terminally) and human full-length MKNK1 (amino acids 1-424 and T344D of accession n...


US Patent US10487092 (2019)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1)


(Homo sapiens (Human))
BDBM420094
PNG
(3-Azabicyclo[3.1.0]hex-3-yl[(7S)-4-(pyrazolo[1,5-a...)
Show SMILES O=C([C@H]1CCc2c(C1)sc1ncnc(Nc3ccn4nccc4c3)c21)N1CC2CC2C1
Show InChI InChI=1S/C23H22N6OS/c30-23(28-10-14-7-15(14)11-28)13-1-2-18-19(8-13)31-22-20(18)21(24-12-25-22)27-16-4-6-29-17(9-16)3-5-26-29/h3-6,9,12-15H,1-2,7-8,10-11H2,(H,24,25,27)/t13-,14?,15?/m0/s1
PDB

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n/an/a 24n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
A recombinant fusion protein of Glutathione-S-Transferase (GST, N-terminally) and human full-length MKNK1 (amino acids 1-424 and T344D of accession n...


US Patent US10487092 (2019)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1)


(Homo sapiens (Human))
BDBM420204
PNG
((7S)óN-(3-Chlorophenyl)-4-[(6-methoxypyrazolo[1,5-...)
Show SMILES COc1cn2nccc2nc1Nc1ncnc2sc3C[C@H](CCc3c12)C(=O)Nc1cccc(Cl)c1
Show InChI InChI=1S/C24H20ClN7O2S/c1-34-17-11-32-19(7-8-28-32)30-21(17)31-22-20-16-6-5-13(9-18(16)35-24(20)27-12-26-22)23(33)29-15-4-2-3-14(25)10-15/h2-4,7-8,10-13H,5-6,9H2,1H3,(H,29,33)(H,26,27,30,31)/t13-/m0/s1
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n/an/a 24n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
A recombinant fusion protein of Glutathione-S-Transferase (GST, N-terminally) and human full-length MKNK1 (amino acids 1-424 and T344D of accession n...


US Patent US10487092 (2019)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1)


(Homo sapiens (Human))
BDBM420125
PNG
(US10487092, Example 32 | [4-(Dimethylamino)piperid...)
Show SMILES CN(C)C1CCN(CC1)C(=O)[C@H]1CCc2c(C1)sc1ncnc(Nc3ccn4nccc4c3)c21
Show InChI InChI=1S/C25H29N7OS/c1-30(2)18-7-10-31(11-8-18)25(33)16-3-4-20-21(13-16)34-24-22(20)23(26-15-27-24)29-17-6-12-32-19(14-17)5-9-28-32/h5-6,9,12,14-16,18H,3-4,7-8,10-11,13H2,1-2H3,(H,26,27,29)/t16-/m0/s1
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n/an/a 25n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
A recombinant fusion protein of Glutathione-S-Transferase (GST, N-terminally) and human full-length MKNK1 (amino acids 1-424 and T344D of accession n...


US Patent US10487092 (2019)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1)


(Homo sapiens (Human))
BDBM420131
PNG
(US10487092, Example 38 | [(1S,4S)-5-Methyl-2,5-dia...)
Show SMILES CN1C[C@@H]2C[C@H]1CN2C(=O)[C@H]1CCc2c(C1)sc1ncnc(Nc3ccn4nccc4c3)c21
Show InChI InChI=1S/C24H25N7OS/c1-29-11-18-10-17(29)12-30(18)24(32)14-2-3-19-20(8-14)33-23-21(19)22(25-13-26-23)28-15-5-7-31-16(9-15)4-6-27-31/h4-7,9,13-14,17-18H,2-3,8,10-12H2,1H3,(H,25,26,28)/t14-,17-,18-/m0/s1
PDB

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n/an/a 25n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
A recombinant fusion protein of Glutathione-S-Transferase (GST, N-terminally) and human full-length MKNK1 (amino acids 1-424 and T344D of accession n...


US Patent US10487092 (2019)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1)


(Homo sapiens (Human))
BDBM420109
PNG
(Azetidin-1-yl[(7S)-4-(pyrazolo[1,5-a]pyridin-5-yla...)
Show SMILES O=C([C@H]1CCc2c(C1)sc1ncnc(Nc3ccn4nccc4c3)c21)N1CCC1
Show InChI InChI=1S/C21H20N6OS/c28-21(26-7-1-8-26)13-2-3-16-17(10-13)29-20-18(16)19(22-12-23-20)25-14-5-9-27-15(11-14)4-6-24-27/h4-6,9,11-13H,1-3,7-8,10H2,(H,22,23,25)/t13-/m0/s1
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n/an/a 26n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
A recombinant fusion protein of Glutathione-S-Transferase (GST, N-terminally) and human full-length MKNK1 (amino acids 1-424 and T344D of accession n...


US Patent US10487092 (2019)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1)


(Homo sapiens (Human))
BDBM420124
PNG
(US10487092, Example 31 | {4-[2-(Dimethylamino)ethy...)
Show SMILES CN(C)CCN1CCN(CC1)C(=O)[C@H]1CCc2c(C1)sc1ncnc(Nc3ccn4nccc4c3)c21
Show InChI InChI=1S/C26H32N8OS/c1-31(2)9-10-32-11-13-33(14-12-32)26(35)18-3-4-21-22(15-18)36-25-23(21)24(27-17-28-25)30-19-6-8-34-20(16-19)5-7-29-34/h5-8,16-18H,3-4,9-15H2,1-2H3,(H,27,28,30)/t18-/m0/s1
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n/an/a 26n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
A recombinant fusion protein of Glutathione-S-Transferase (GST, N-terminally) and human full-length MKNK1 (amino acids 1-424 and T344D of accession n...


US Patent US10487092 (2019)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1)


(Homo sapiens (Human))
BDBM420168
PNG
((7S)-4-[(6-Chloropyrazolo[1,5-a]pyridin-5-yl)amino...)
Show SMILES CCN(CCN(C)C)C(=O)[C@H]1CCc2c(C1)sc1ncnc(Nc3cc4ccnn4cc3Cl)c21
Show InChI InChI=1S/C24H28ClN7OS/c1-4-31(10-9-30(2)3)24(33)15-5-6-17-20(11-15)34-23-21(17)22(26-14-27-23)29-19-12-16-7-8-28-32(16)13-18(19)25/h7-8,12-15H,4-6,9-11H2,1-3H3,(H,26,27,29)/t15-/m0/s1
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n/an/a 30n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
A recombinant fusion protein of Glutathione-S-Transferase (GST, N-terminally) and human full-length MKNK1 (amino acids 1-424 and T344D of accession n...


US Patent US10487092 (2019)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1)


(Homo sapiens (Human))
BDBM420105
PNG
((7S)óN,N-Dimethyl-4-(pyrazolo[1,5-a]pyridin-5-ylam...)
Show SMILES CN(C)C(=O)[C@H]1CCc2c(C1)sc1ncnc(Nc3ccn4nccc4c3)c21
Show InChI InChI=1S/C20H20N6OS/c1-25(2)20(27)12-3-4-15-16(9-12)28-19-17(15)18(21-11-22-19)24-13-6-8-26-14(10-13)5-7-23-26/h5-8,10-12H,3-4,9H2,1-2H3,(H,21,22,24)/t12-/m0/s1
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n/an/a 33n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
A recombinant fusion protein of Glutathione-S-Transferase (GST, N-terminally) and human full-length MKNK1 (amino acids 1-424 and T344D of accession n...


US Patent US10487092 (2019)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1)


(Homo sapiens (Human))
BDBM420092
PNG
(US10487092, Example 10 | [(2R,6R)-2,6-Dimethylmorp...)
Show SMILES C[C@@H]1CN(C[C@@H](C)O1)C(=O)[C@H]1CCc2c(C1)sc1ncnc(Nc3ccn4nccc4c3)c21
Show InChI InChI=1S/C24H26N6O2S/c1-14-11-29(12-15(2)32-14)24(31)16-3-4-19-20(9-16)33-23-21(19)22(25-13-26-23)28-17-6-8-30-18(10-17)5-7-27-30/h5-8,10,13-16H,3-4,9,11-12H2,1-2H3,(H,25,26,28)/t14-,15-,16+/m1/s1
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n/an/a 33n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
A recombinant fusion protein of Glutathione-S-Transferase (GST, N-terminally) and human full-length MKNK1 (amino acids 1-424 and T344D of accession n...


US Patent US10487092 (2019)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1)


(Homo sapiens (Human))
BDBM420141
PNG
((7S)-4-[(6-Chloropyrazolo[1,5-a]pyridin-5-yl)amino...)
Show SMILES CN(CCC(F)(F)F)C(=O)[C@H]1CCc2c(C1)sc1ncnc(Nc3cc4ccnn4cc3Cl)c21
Show InChI InChI=1S/C22H20ClF3N6OS/c1-31(7-5-22(24,25)26)21(33)12-2-3-14-17(8-12)34-20-18(14)19(27-11-28-20)30-16-9-13-4-6-29-32(13)10-15(16)23/h4,6,9-12H,2-3,5,7-8H2,1H3,(H,27,28,30)/t12-/m0/s1
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n/an/a 35n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
A recombinant fusion protein of Glutathione-S-Transferase (GST, N-terminally) and human full-length MKNK1 (amino acids 1-424 and T344D of accession n...


US Patent US10487092 (2019)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1)


(Homo sapiens (Human))
BDBM420136
PNG
((7S)-4-[(6-Chloropyrazolo[1,5-a]pyridin-5-yl)amino...)
Show SMILES FC(F)(F)CCNC(=O)[C@H]1CCc2c(C1)sc1ncnc(Nc3cc4ccnn4cc3Cl)c21
Show InChI InChI=1S/C21H18ClF3N6OS/c22-14-9-31-12(3-5-29-31)8-15(14)30-18-17-13-2-1-11(19(32)26-6-4-21(23,24)25)7-16(13)33-20(17)28-10-27-18/h3,5,8-11H,1-2,4,6-7H2,(H,26,32)(H,27,28,30)/t11-/m0/s1
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n/an/a 35n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
A recombinant fusion protein of Glutathione-S-Transferase (GST, N-terminally) and human full-length MKNK1 (amino acids 1-424 and T344D of accession n...


US Patent US10487092 (2019)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1)


(Homo sapiens (Human))
BDBM420116
PNG
(US10487092, Example 25 | US10487092, Example 39 | ...)
Show SMILES CN(CCNC(=O)OC(C)(C)C)C(=O)[C@H]1CCc2c(C1)sc1ncnc(Nc3ccn4nccc4c3)c21
Show InChI InChI=1S/C26H31N7O3S/c1-26(2,3)36-25(35)27-10-12-32(4)24(34)16-5-6-19-20(13-16)37-23-21(19)22(28-15-29-23)31-17-8-11-33-18(14-17)7-9-30-33/h7-9,11,14-16H,5-6,10,12-13H2,1-4H3,(H,27,35)(H,28,29,31)/t16-/m0/s1
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n/an/a 41n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
A recombinant fusion protein of Glutathione-S-Transferase (GST, N-terminally) and human full-length MKNK1 (amino acids 1-424 and T344D of accession n...


US Patent US10487092 (2019)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1)


(Homo sapiens (Human))
BDBM420151
PNG
((7S)-4-[(6-Chloropyrazolo[1,5-a]pyridin-5-yl)amino...)
Show SMILES COCCN(C)C(=O)[C@H]1CCc2c(C1)sc1ncnc(Nc3cc4ccnn4cc3Cl)c21
Show InChI InChI=1S/C22H23ClN6O2S/c1-28(7-8-31-2)22(30)13-3-4-15-18(9-13)32-21-19(15)20(24-12-25-21)27-17-10-14-5-6-26-29(14)11-16(17)23/h5-6,10-13H,3-4,7-9H2,1-2H3,(H,24,25,27)/t13-/m0/s1
PDB

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n/an/a 41n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
A recombinant fusion protein of Glutathione-S-Transferase (GST, N-terminally) and human full-length MKNK1 (amino acids 1-424 and T344D of accession n...


US Patent US10487092 (2019)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1)


(Homo sapiens (Human))
BDBM420088
PNG
((7S)óN-(2-Methoxyethyl)-N-methyl-4-(pyrazolo[1,5-a...)
Show SMILES COCCN(C)C(=O)[C@H]1CCc2c(C1)sc1ncnc(Nc3ccn4nccc4c3)c21
Show InChI InChI=1S/C22H24N6O2S/c1-27(9-10-30-2)22(29)14-3-4-17-18(11-14)31-21-19(17)20(23-13-24-21)26-15-6-8-28-16(12-15)5-7-25-28/h5-8,12-14H,3-4,9-11H2,1-2H3,(H,23,24,26)/t14-/m0/s1
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n/an/a 42n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
A recombinant fusion protein of Glutathione-S-Transferase (GST, N-terminally) and human full-length MKNK1 (amino acids 1-424 and T344D of accession n...


US Patent US10487092 (2019)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1)


(Homo sapiens (Human))
BDBM420208
PNG
((7S)óN-(3-Chloro-4-fluorophenyl)-4-[(6-methoxypyra...)
Show SMILES COc1cn2nccc2cc1Nc1ncnc2sc3C[C@H](CCc3c12)C(=O)Nc1ccc(F)c(Cl)c1
Show InChI InChI=1S/C25H20ClFN6O2S/c1-35-20-11-33-15(6-7-30-33)10-19(20)32-23-22-16-4-2-13(8-21(16)36-25(22)29-12-28-23)24(34)31-14-3-5-18(27)17(26)9-14/h3,5-7,9-13H,2,4,8H2,1H3,(H,31,34)(H,28,29,32)/t13-/m0/s1
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n/an/a 48n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
A recombinant fusion protein of Glutathione-S-Transferase (GST, N-terminally) and human full-length MKNK1 (amino acids 1-424 and T344D of accession n...


US Patent US10487092 (2019)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1)


(Homo sapiens (Human))
BDBM420089
PNG
(US10487092, Example 9 | [(2S,6S)-2,6-Dimethylmorph...)
Show SMILES C[C@H]1CN(C[C@H](C)O1)C(=O)[C@H]1CCc2c(C1)sc1ncnc(Nc3ccn4nccc4c3)c21
Show InChI InChI=1S/C24H26N6O2S/c1-14-11-29(12-15(2)32-14)24(31)16-3-4-19-20(9-16)33-23-21(19)22(25-13-26-23)28-17-6-8-30-18(10-17)5-7-27-30/h5-8,10,13-16H,3-4,9,11-12H2,1-2H3,(H,25,26,28)/t14-,15-,16-/m0/s1
PDB

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n/an/a 49n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
A recombinant fusion protein of Glutathione-S-Transferase (GST, N-terminally) and human full-length MKNK1 (amino acids 1-424 and T344D of accession n...


US Patent US10487092 (2019)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1)


(Homo sapiens (Human))
BDBM420137
PNG
((7S)-4-[(6-Chloropyrazolo[1,5-a]pyridin-5-yl)amino...)
Show SMILES CC(C)NC(=O)[C@H]1CCc2c(C1)sc1ncnc(Nc3cc4ccnn4cc3Cl)c21
Show InChI InChI=1S/C21H21ClN6OS/c1-11(2)26-20(29)12-3-4-14-17(7-12)30-21-18(14)19(23-10-24-21)27-16-8-13-5-6-25-28(13)9-15(16)22/h5-6,8-12H,3-4,7H2,1-2H3,(H,26,29)(H,23,24,27)/t12-/m0/s1
PDB

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n/an/a 54n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
A recombinant fusion protein of Glutathione-S-Transferase (GST, N-terminally) and human full-length MKNK1 (amino acids 1-424 and T344D of accession n...


US Patent US10487092 (2019)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1)


(Homo sapiens (Human))
BDBM420187
PNG
((7S)-4-[(6-Chloropyrazolo[1,5-a]pyridin-5-yl)amino...)
Show SMILES Clc1cn2nccc2cc1Nc1ncnc2sc3C[C@H](CCc3c12)C(=O)N1C[C@H]2C[C@@H]1CO2
Show InChI InChI=1S/C23H21ClN6O2S/c24-17-9-30-13(3-4-27-30)7-18(17)28-21-20-16-2-1-12(5-19(16)33-22(20)26-11-25-21)23(31)29-8-15-6-14(29)10-32-15/h3-4,7,9,11-12,14-15H,1-2,5-6,8,10H2,(H,25,26,28)/t12-,14+,15+/m0/s1
PDB

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n/an/a 56n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
A recombinant fusion protein of Glutathione-S-Transferase (GST, N-terminally) and human full-length MKNK1 (amino acids 1-424 and T344D of accession n...


US Patent US10487092 (2019)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1)


(Homo sapiens (Human))
BDBM420130
PNG
((1R,4R)-2-Oxa-5-azabicyclo[2.2.1]hept-5-yl[(7S)-4-...)
Show SMILES O=C([C@H]1CCc2c(C1)sc1ncnc(Nc3ccn4nccc4c3)c21)N1C[C@H]2C[C@@H]1CO2
Show InChI InChI=1S/C23H22N6O2S/c30-23(28-10-17-9-16(28)11-31-17)13-1-2-18-19(7-13)32-22-20(18)21(24-12-25-22)27-14-4-6-29-15(8-14)3-5-26-29/h3-6,8,12-13,16-17H,1-2,7,9-11H2,(H,24,25,27)/t13-,16+,17+/m0/s1
PDB

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n/an/a 56n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
A recombinant fusion protein of Glutathione-S-Transferase (GST, N-terminally) and human full-length MKNK1 (amino acids 1-424 and T344D of accession n...


US Patent US10487092 (2019)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1)


(Homo sapiens (Human))
BDBM420093
PNG
(Morpholin-4-yl[(7S)-4-(pyrazolo[1,5-a]pyridin-5-yl...)
Show SMILES O=C([C@H]1CCc2c(C1)sc1ncnc(Nc3ccn4nccc4c3)c21)N1CCOCC1
Show InChI InChI=1S/C22H22N6O2S/c29-22(27-7-9-30-10-8-27)14-1-2-17-18(11-14)31-21-19(17)20(23-13-24-21)26-15-4-6-28-16(12-15)3-5-25-28/h3-6,12-14H,1-2,7-11H2,(H,23,24,26)/t14-/m0/s1
PDB

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n/an/a 62n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
A recombinant fusion protein of Glutathione-S-Transferase (GST, N-terminally) and human full-length MKNK1 (amino acids 1-424 and T344D of accession n...


US Patent US10487092 (2019)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1)


(Homo sapiens (Human))
BDBM420066
PNG
((RS) N,N-Dimethyl-4-(pyrazolo[1,5-a]pyridin-5-ylam...)
Show SMILES CN(C)C(=O)C1CCc2c(C1)sc1ncnc(Nc3ccn4nccc4c3)c21
Show InChI InChI=1S/C20H20N6OS/c1-25(2)20(27)12-3-4-15-16(9-12)28-19-17(15)18(21-11-22-19)24-13-6-8-26-14(10-13)5-7-23-26/h5-8,10-12H,3-4,9H2,1-2H3,(H,21,22,24)
PDB

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n/an/a 64n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
A recombinant fusion protein of Glutathione-S-Transferase (GST, N-terminally) and human full-length MKNK1 (amino acids 1-424 and T344D of accession n...


US Patent US10487092 (2019)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1)


(Homo sapiens (Human))
BDBM420086
PNG
(US10487092, Example 7 | [(3S)-3-Methylmorpholin-4-...)
Show SMILES C[C@H]1COCCN1C(=O)[C@H]1CCc2c(C1)sc1ncnc(Nc3ccn4nccc4c3)c21
Show InChI InChI=1S/C23H24N6O2S/c1-14-12-31-9-8-28(14)23(30)15-2-3-18-19(10-15)32-22-20(18)21(24-13-25-22)27-16-5-7-29-17(11-16)4-6-26-29/h4-7,11,13-15H,2-3,8-10,12H2,1H3,(H,24,25,27)/t14-,15-/m0/s1
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n/an/a 65n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
A recombinant fusion protein of Glutathione-S-Transferase (GST, N-terminally) and human full-length MKNK1 (amino acids 1-424 and T344D of accession n...


US Patent US10487092 (2019)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1)


(Homo sapiens (Human))
BDBM420127
PNG
((3,3-Difluoropyrrolidin-1-yl)[(7S)-4-(pyrazolo[1,5...)
Show SMILES FC1(F)CCN(C1)C(=O)[C@H]1CCc2c(C1)sc1ncnc(Nc3ccn4nccc4c3)c21
Show InChI InChI=1S/C22H20F2N6OS/c23-22(24)5-8-29(11-22)21(31)13-1-2-16-17(9-13)32-20-18(16)19(25-12-26-20)28-14-4-7-30-15(10-14)3-6-27-30/h3-4,6-7,10,12-13H,1-2,5,8-9,11H2,(H,25,26,28)/t13-/m0/s1
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n/an/a 71n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
A recombinant fusion protein of Glutathione-S-Transferase (GST, N-terminally) and human full-length MKNK1 (amino acids 1-424 and T344D of accession n...


US Patent US10487092 (2019)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1)


(Homo sapiens (Human))
BDBM420128
PNG
(2-Oxa-6-azaspiro[3.3]hept-6-yl[(7S)-4-(pyrazolo[1,...)
Show SMILES O=C([C@H]1CCc2c(C1)sc1ncnc(Nc3ccn4nccc4c3)c21)N1CC2(COC2)C1
Show InChI InChI=1S/C23H22N6O2S/c30-22(28-9-23(10-28)11-31-12-23)14-1-2-17-18(7-14)32-21-19(17)20(24-13-25-21)27-15-4-6-29-16(8-15)3-5-26-29/h3-6,8,13-14H,1-2,7,9-12H2,(H,24,25,27)/t14-/m0/s1
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n/an/a 75n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
A recombinant fusion protein of Glutathione-S-Transferase (GST, N-terminally) and human full-length MKNK1 (amino acids 1-424 and T344D of accession n...


US Patent US10487092 (2019)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1)


(Homo sapiens (Human))
BDBM420076
PNG
(US10487092, Example 3 | [(3R)-3-Methylmorpholin-4-...)
Show SMILES C[C@@H]1COCCN1C(=O)[C@H]1CCc2c(C1)sc1ncnc(Nc3ccn4nccc4c3)c21
Show InChI InChI=1S/C23H24N6O2S/c1-14-12-31-9-8-28(14)23(30)15-2-3-18-19(10-15)32-22-20(18)21(24-13-25-22)27-16-5-7-29-17(11-16)4-6-26-29/h4-7,11,13-15H,2-3,8-10,12H2,1H3,(H,24,25,27)/t14-,15+/m1/s1
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n/an/a 80n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
A recombinant fusion protein of Glutathione-S-Transferase (GST, N-terminally) and human full-length MKNK1 (amino acids 1-424 and T344D of accession n...


US Patent US10487092 (2019)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1)


(Homo sapiens (Human))
BDBM420129
PNG
((1S,4S)-2-Oxa-5-azabicyclo[2.2.1]hept-5-yl[(7S)-4-...)
Show SMILES O=C([C@H]1CCc2c(C1)sc1ncnc(Nc3ccn4nccc4c3)c21)N1C[C@@H]2C[C@H]1CO2
Show InChI InChI=1S/C23H22N6O2S/c30-23(28-10-17-9-16(28)11-31-17)13-1-2-18-19(7-13)32-22-20(18)21(24-12-25-22)27-14-4-6-29-15(8-14)3-5-26-29/h3-6,8,12-13,16-17H,1-2,7,9-11H2,(H,24,25,27)/t13-,16-,17-/m0/s1
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n/an/a 91n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
A recombinant fusion protein of Glutathione-S-Transferase (GST, N-terminally) and human full-length MKNK1 (amino acids 1-424 and T344D of accession n...


US Patent US10487092 (2019)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1)


(Homo sapiens (Human))
BDBM420126
PNG
(1-{[(7S)-4-(Pyrazolo[1,5-a]pyridin-5-ylamino)-5,6,...)
Show SMILES O=C([C@H]1CCc2c(C1)sc1ncnc(Nc3ccn4nccc4c3)c21)N1CCC(=O)CC1
Show InChI InChI=1S/C23H22N6O2S/c30-17-5-8-28(9-6-17)23(31)14-1-2-18-19(11-14)32-22-20(18)21(24-13-25-22)27-15-4-10-29-16(12-15)3-7-26-29/h3-4,7,10,12-14H,1-2,5-6,8-9,11H2,(H,24,25,27)/t14-/m0/s1
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n/an/a 96n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
A recombinant fusion protein of Glutathione-S-Transferase (GST, N-terminally) and human full-length MKNK1 (amino acids 1-424 and T344D of accession n...


US Patent US10487092 (2019)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1)


(Homo sapiens (Human))
BDBM420206
PNG
((7S)óN-(3,4-Dichlorophenyl)-4-[(6-methoxypyrazolo[...)
Show SMILES COc1cn2nccc2nc1Nc1ncnc2sc3C[C@H](CCc3c12)C(=O)Nc1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C24H19Cl2N7O2S/c1-35-17-10-33-19(6-7-29-33)31-21(17)32-22-20-14-4-2-12(8-18(14)36-24(20)28-11-27-22)23(34)30-13-3-5-15(25)16(26)9-13/h3,5-7,9-12H,2,4,8H2,1H3,(H,30,34)(H,27,28,31,32)/t12-/m0/s1
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n/an/a 235n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
A recombinant fusion protein of Glutathione-S-Transferase (GST, N-terminally) and human full-length MKNK1 (amino acids 1-424 and T344D of accession n...


US Patent US10487092 (2019)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1)


(Homo sapiens (Human))
BDBM420070
PNG
((7S)-4-(Pyrazolo[1,5-a]pyridin-5-ylamino)-5,6,7,8-...)
Show SMILES CCOC(=O)[C@H]1CCc2c(C1)sc1ncnc(Nc3ccn4nccc4c3)c21
Show InChI InChI=1S/C20H19N5O2S/c1-2-27-20(26)12-3-4-15-16(9-12)28-19-17(15)18(21-11-22-19)24-13-6-8-25-14(10-13)5-7-23-25/h5-8,10-12H,2-4,9H2,1H3,(H,21,22,24)/t12-/m0/s1
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n/an/a 707n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
A recombinant fusion protein of Glutathione-S-Transferase (GST, N-terminally) and human full-length MKNK1 (amino acids 1-424 and T344D of accession n...


US Patent US10487092 (2019)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%