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Patent code US10550096

Compile Data Set for Download or QSAR
Found 5 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM430630
PNG
(US10550096, Example 3)
Show SMILES CCc1nn(C[C@@H](O)[C@@H]2Cc3ccccc3CN2)c(=O)c2ccc(cc12)C(=O)N1C2CCC1COC2
Show InChI InChI=1S/C28H32N4O4/c1-2-24-23-11-18(27(34)32-20-8-9-21(32)16-36-15-20)7-10-22(23)28(35)31(30-24)14-26(33)25-12-17-5-3-4-6-19(17)13-29-25/h3-7,10-11,20-21,25-26,29,33H,2,8-9,12-16H2,1H3/t20?,21?,25-,26+/m0/s1
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n/an/a 1n/an/an/an/an/an/a



CTXT PTY LTD

US Patent


Assay Description
The cell line TE11 was seeded at a density of 6,000 cells per well in 96 well optical quality tissue culture plates in DME medium and 10% foetal bovi...


US Patent US10550096 (2020)


BindingDB Entry DOI: 10.7270/Q2T43WH2
More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM430630
PNG
(US10550096, Example 3)
Show SMILES CCc1nn(C[C@@H](O)[C@@H]2Cc3ccccc3CN2)c(=O)c2ccc(cc12)C(=O)N1C2CCC1COC2
Show InChI InChI=1S/C28H32N4O4/c1-2-24-23-11-18(27(34)32-20-8-9-21(32)16-36-15-20)7-10-22(23)28(35)31(30-24)14-26(33)25-12-17-5-3-4-6-19(17)13-29-25/h3-7,10-11,20-21,25-26,29,33H,2,8-9,12-16H2,1H3/t20?,21?,25-,26+/m0/s1
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n/an/a 39n/an/an/an/an/an/a



CTXT PTY LTD

US Patent


Assay Description
A histone H4 derived peptide is used as substrate (amino acid sequence: Ser-Gly-Arg-Gly-Lys-Gly-Gly-Lys-Gly-Leu-Gly-Lys-Gly-Gly-Ala-Lys-Arg-His-Arg-L...


US Patent US10550096 (2020)


BindingDB Entry DOI: 10.7270/Q2T43WH2
More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM430625
PNG
(US10550096, Example 1)
Show SMILES O[C@H](Cn1ccc2cc(ccc2c1=O)C(=O)N1C2CCC1COC2)[C@@H]1Cc2ccccc2CN1
Show InChI InChI=1S/C27H29N3O4/c31-25(24-12-17-3-1-2-4-20(17)13-28-24)14-29-10-9-18-11-19(5-8-23(18)27(29)33)26(32)30-21-6-7-22(30)16-34-15-21/h1-5,8-11,21-22,24-25,28,31H,6-7,12-16H2/t21?,22?,24-,25+/m0/s1
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n/an/a 430n/an/an/an/an/an/a



CTXT PTY LTD

US Patent


Assay Description
The cell line TE11 was seeded at a density of 6,000 cells per well in 96 well optical quality tissue culture plates in DME medium and 10% foetal bovi...


US Patent US10550096 (2020)


BindingDB Entry DOI: 10.7270/Q2T43WH2
More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM430625
PNG
(US10550096, Example 1)
Show SMILES O[C@H](Cn1ccc2cc(ccc2c1=O)C(=O)N1C2CCC1COC2)[C@@H]1Cc2ccccc2CN1
Show InChI InChI=1S/C27H29N3O4/c31-25(24-12-17-3-1-2-4-20(17)13-28-24)14-29-10-9-18-11-19(5-8-23(18)27(29)33)26(32)30-21-6-7-22(30)16-34-15-21/h1-5,8-11,21-22,24-25,28,31H,6-7,12-16H2/t21?,22?,24-,25+/m0/s1
PDB

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n/an/a 533n/an/an/an/an/an/a



CTXT PTY LTD

US Patent


Assay Description
A histone H4 derived peptide is used as substrate (amino acid sequence: Ser-Gly-Arg-Gly-Lys-Gly-Gly-Lys-Gly-Leu-Gly-Lys-Gly-Gly-Ala-Lys-Arg-His-Arg-L...


US Patent US10550096 (2020)


BindingDB Entry DOI: 10.7270/Q2T43WH2
More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM430627
PNG
(US10550096, Example 2)
Show SMILES Cc1nn(C[C@@H](O)[C@@H]2Cc3ccccc3CN2)c(=O)c2ccccc12
Show InChI InChI=1S/C20H21N3O2/c1-13-16-8-4-5-9-17(16)20(25)23(22-13)12-19(24)18-10-14-6-2-3-7-15(14)11-21-18/h2-9,18-19,21,24H,10-12H2,1H3/t18-,19+/m0/s1
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n/an/a 7.32E+3n/an/an/an/an/an/a



CTXT PTY LTD

US Patent


Assay Description
A histone H4 derived peptide is used as substrate (amino acid sequence: Ser-Gly-Arg-Gly-Lys-Gly-Gly-Lys-Gly-Leu-Gly-Lys-Gly-Gly-Ala-Lys-Arg-His-Arg-L...


US Patent US10550096 (2020)


BindingDB Entry DOI: 10.7270/Q2T43WH2
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%