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Found 455 Enz. Inhib. hit(s) with all data for entry = 8927
TargetADAMTS5(Rattus norvegicus (Rat))
Galapagos

US Patent
LigandPNGBDBM429695(5-(3-(4-(3- fluorophenyl) piperidin-1-yl)- 2-methy...)
Affinity DataIC50:  12.5nMAssay Description:The basis for the assay is the cleavage of the substrate TBIS-1 (5 FAM-TEGEARGSVILLK (5TAMRA)K-NH2) (SEQ ID NO: 2) by rnADAMTS-5 (1-564-6H).For the d...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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LigandPNGBDBM429748((R)-5-(3-(4- (3,4-dichloro-5- methoxyphenyl) piper...)
Affinity DataIC50:  12.5nMAssay Description:The basis for the assay is the cleavage of the substrate 520 MMP FRET substrate XII by human ADAMTS6.The substrate contains sequence Arg-Pro-Lys-Pro-...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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LigandPNGBDBM429750(5-(3-(4-(4,5- dichloro-2- methylphenyl) piperidin-...)
Affinity DataIC50:  12.5nMAssay Description:The basis for the assay is the cleavage of the substrate 520 MMP FRET substrate XII by human ADAMTS6.The substrate contains sequence Arg-Pro-Lys-Pro-...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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LigandPNGBDBM429751(5-(3-(4-(4- fluoro-3,5- dimethoxyphenyl) piperidin...)
Affinity DataIC50:  12.5nMAssay Description:The basis for the assay is the cleavage of the substrate 520 MMP FRET substrate XII by human ADAMTS6.The substrate contains sequence Arg-Pro-Lys-Pro-...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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LigandPNGBDBM429752(5-(3-(4-(3- chloro-4- fluoro-5- methoxyphenyl) pip...)
Affinity DataIC50:  12.5nMAssay Description:The basis for the assay is the cleavage of the substrate 520 MMP FRET substrate XII by human ADAMTS6.The substrate contains sequence Arg-Pro-Lys-Pro-...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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LigandPNGBDBM429758((5R)-5-[3-[4- (4-chloro-2- methoxy- phenyl)-1- pip...)
Affinity DataIC50:  12.5nMAssay Description:The basis for the assay is the cleavage of the substrate 520 MMP FRET substrate XII by human ADAMTS6.The substrate contains sequence Arg-Pro-Lys-Pro-...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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LigandPNGBDBM429759((5R)-5-[3-[4- (3-chloro-4- fluoro-5- methoxy- phen...)
Affinity DataIC50:  12.5nMAssay Description:The basis for the assay is the cleavage of the substrate 520 MMP FRET substrate XII by human ADAMTS6.The substrate contains sequence Arg-Pro-Lys-Pro-...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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LigandPNGBDBM429760((5R)-5-[3-[4- (4-fluoro-3,5- dimethoxy- phenyl)-1-...)
Affinity DataIC50:  12.5nMAssay Description:The basis for the assay is the cleavage of the substrate 520 MMP FRET substrate XII by human ADAMTS6.The substrate contains sequence Arg-Pro-Lys-Pro-...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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LigandPNGBDBM429761((5R)-5-[3-[4- (4-fluoro-3,5- dimethoxy- phenyl)-1-...)
Affinity DataIC50:  12.5nMAssay Description:The basis for the assay is the cleavage of the substrate 520 MMP FRET substrate XII by human ADAMTS6.The substrate contains sequence Arg-Pro-Lys-Pro-...More data for this Ligand-Target Pair
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LigandPNGBDBM429763((5R)-5-[3-[4- (4-chloro-3- fluoro-5- methoxy- phen...)
Affinity DataIC50:  12.5nMAssay Description:The basis for the assay is the cleavage of the substrate 520 MMP FRET substrate XII by human ADAMTS6.The substrate contains sequence Arg-Pro-Lys-Pro-...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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LigandPNGBDBM429765((5R)-5-[3-[4- (4-chloro-3- methoxy- phenyl)-1- pip...)
Affinity DataIC50:  12.5nMAssay Description:The basis for the assay is the cleavage of the substrate 520 MMP FRET substrate XII by human ADAMTS6.The substrate contains sequence Arg-Pro-Lys-Pro-...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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LigandPNGBDBM429767((5R)-5-[3-[4- (4-chloro-3- ethoxy-5- methoxy- phen...)
Affinity DataIC50:  12.5nMAssay Description:The basis for the assay is the cleavage of the substrate 520 MMP FRET substrate XII by human ADAMTS6.The substrate contains sequence Arg-Pro-Lys-Pro-...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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LigandPNGBDBM429768((5R)-5-[3-[4- (4-chloro-3- ethoxy-5- methoxy- phen...)
Affinity DataIC50:  12.5nMAssay Description:The basis for the assay is the cleavage of the substrate 520 MMP FRET substrate XII by human ADAMTS6.The substrate contains sequence Arg-Pro-Lys-Pro-...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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LigandPNGBDBM429769((5R)-5-[3-[4- (4-chloro-2- methoxy-5- methyl- phen...)
Affinity DataIC50:  12.5nMAssay Description:The basis for the assay is the cleavage of the substrate 520 MMP FRET substrate XII by human ADAMTS6.The substrate contains sequence Arg-Pro-Lys-Pro-...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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LigandPNGBDBM429770((5R)-5-[3-[4- [4-chloro-3- (dimethylamino)- 5-meth...)
Affinity DataIC50:  12.5nMAssay Description:The basis for the assay is the cleavage of the substrate 520 MMP FRET substrate XII by human ADAMTS6.The substrate contains sequence Arg-Pro-Lys-Pro-...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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LigandPNGBDBM429795(5-[3-[4-(4,5- dichloro-2- methoxy- phenyl)-1- pipe...)
Affinity DataIC50:  12.5nMAssay Description:The basis for the assay is the cleavage of the substrate 520 MMP FRET substrate XII by human ADAMTS6.The substrate contains sequence Arg-Pro-Lys-Pro-...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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LigandPNGBDBM429771((5R)-5-[3-[4- (4-chloro-3,5- dimethyl- phenyl)-1- ...)
Affinity DataIC50:  12.5nMAssay Description:The basis for the assay is the cleavage of the substrate 520 MMP FRET substrate XII by human ADAMTS6.The substrate contains sequence Arg-Pro-Lys-Pro-...More data for this Ligand-Target Pair
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LigandPNGBDBM429797((5R)-5-[3-[4- (4-chloro-3- methyl- phenyl)-1- pipe...)
Affinity DataIC50:  12.5nMAssay Description:The basis for the assay is the cleavage of the substrate 520 MMP FRET substrate XII by human ADAMTS6.The substrate contains sequence Arg-Pro-Lys-Pro-...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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LigandPNGBDBM429772((5R)-5-[3-[4- (4,5-dichloro- 2-methoxy- phenyl)-1-...)
Affinity DataIC50:  12.5nMAssay Description:The basis for the assay is the cleavage of the substrate 520 MMP FRET substrate XII by human ADAMTS6.The substrate contains sequence Arg-Pro-Lys-Pro-...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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LigandPNGBDBM429773(5-[3-[4-(4- chloro-2- methoxy- phenyl)-1- piperidy...)
Affinity DataIC50:  12.5nMAssay Description:The basis for the assay is the cleavage of the substrate 520 MMP FRET substrate XII by human ADAMTS6.The substrate contains sequence Arg-Pro-Lys-Pro-...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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LigandPNGBDBM429774((5R)-5-[3-[4- (4-chloro-3- methoxy-5- methyl- phen...)
Affinity DataIC50:  12.5nMAssay Description:The basis for the assay is the cleavage of the substrate 520 MMP FRET substrate XII by human ADAMTS6.The substrate contains sequence Arg-Pro-Lys-Pro-...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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LigandPNGBDBM429776((5R)-5-[3-[4- (4-chloro-5- fluoro-2- methoxy- phen...)
Affinity DataIC50:  12.5nMAssay Description:The basis for the assay is the cleavage of the substrate 520 MMP FRET substrate XII by human ADAMTS6.The substrate contains sequence Arg-Pro-Lys-Pro-...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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LigandPNGBDBM429778(5-[3-[4-(4- chloro-3- fluoro-5- methoxy- phenyl)-1...)
Affinity DataIC50:  12.5nMAssay Description:The basis for the assay is the cleavage of the substrate 520 MMP FRET substrate XII by human ADAMTS6.The substrate contains sequence Arg-Pro-Lys-Pro-...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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LigandPNGBDBM429779(5-[3-[4-(4- chloro-3- fluoro-5- methoxy- phenyl)-1...)
Affinity DataIC50:  12.5nMAssay Description:The basis for the assay is the cleavage of the substrate 520 MMP FRET substrate XII by human ADAMTS6.The substrate contains sequence Arg-Pro-Lys-Pro-...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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LigandPNGBDBM429780(5-[3-[4-(4- chloro-3-ethyl- 5-methoxy- phenyl)-1- ...)
Affinity DataIC50:  12.5nMAssay Description:The basis for the assay is the cleavage of the substrate 520 MMP FRET substrate XII by human ADAMTS6.The substrate contains sequence Arg-Pro-Lys-Pro-...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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LigandPNGBDBM429781((5R)-5-[3-[4- (4-chloro-3- ethyl-5-methoxy- phenyl...)
Affinity DataIC50:  12.5nMAssay Description:The basis for the assay is the cleavage of the substrate 520 MMP FRET substrate XII by human ADAMTS6.The substrate contains sequence Arg-Pro-Lys-Pro-...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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LigandPNGBDBM429782((5R)-5-[3-[4- (4-chloro-3- ethyl-5- methoxy- pheny...)
Affinity DataIC50:  12.5nMAssay Description:The basis for the assay is the cleavage of the substrate 520 MMP FRET substrate XII by human ADAMTS6.The substrate contains sequence Arg-Pro-Lys-Pro-...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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LigandPNGBDBM429783(5-[3-[4-(5- chloro-4- fluoro-2- methoxy- phenyl)-1...)
Affinity DataIC50:  12.5nMAssay Description:The basis for the assay is the cleavage of the substrate 520 MMP FRET substrate XII by human ADAMTS6.The substrate contains sequence Arg-Pro-Lys-Pro-...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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LigandPNGBDBM429784(5-[3-[4-(4- chloro-2- methoxy- phenyl)-1- piperidy...)
Affinity DataIC50:  12.5nMAssay Description:The basis for the assay is the cleavage of the substrate 520 MMP FRET substrate XII by human ADAMTS6.The substrate contains sequence Arg-Pro-Lys-Pro-...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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LigandPNGBDBM429785(5-[3-[4-(4- chloro-5- fluoro-2- methoxy- phenyl)-1...)
Affinity DataIC50:  12.5nMAssay Description:The basis for the assay is the cleavage of the substrate 520 MMP FRET substrate XII by human ADAMTS6.The substrate contains sequence Arg-Pro-Lys-Pro-...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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LigandPNGBDBM429773(5-[3-[4-(4- chloro-2- methoxy- phenyl)-1- piperidy...)
Affinity DataIC50:  12.5nMAssay Description:The basis for the assay is the cleavage of the substrate 520 MMP FRET substrate XII by human ADAMTS6.The substrate contains sequence Arg-Pro-Lys-Pro-...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM429787(5-[3-[4-(5- chloro-4- fluoro-2- methoxy- phenyl)-1...)
Affinity DataIC50:  12.5nMAssay Description:The basis for the assay is the cleavage of the substrate 520 MMP FRET substrate XII by human ADAMTS6.The substrate contains sequence Arg-Pro-Lys-Pro-...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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LigandPNGBDBM429789(5-[3-[4-(4- chloro-3- methoxy-5- methyl- phenyl)-1...)
Affinity DataIC50:  12.5nMAssay Description:The basis for the assay is the cleavage of the substrate 520 MMP FRET substrate XII by human ADAMTS6.The substrate contains sequence Arg-Pro-Lys-Pro-...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM429790(5-[3-[4-(4- chloro-3- methoxy-5- methyl- phenyl)-1...)
Affinity DataIC50:  12.5nMAssay Description:The basis for the assay is the cleavage of the substrate 520 MMP FRET substrate XII by human ADAMTS6.The substrate contains sequence Arg-Pro-Lys-Pro-...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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LigandPNGBDBM429791((5R)-5-[3-[4- (4-chloro-3- methoxy-5- methyl- phen...)
Affinity DataIC50:  12.5nMAssay Description:The basis for the assay is the cleavage of the substrate 520 MMP FRET substrate XII by human ADAMTS6.The substrate contains sequence Arg-Pro-Lys-Pro-...More data for this Ligand-Target Pair
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TargetA disintegrin and metalloproteinase with thrombospondin motifs 5(Homo sapiens (Human))
Galapagos

US Patent
LigandPNGBDBM429779(5-[3-[4-(4- chloro-3- fluoro-5- methoxy- phenyl)-1...)
Affinity DataIC50:  12.5nMAssay Description:The basis for the assay is the cleavage of the substrate TBIS-1 (5 FAM-TEGEARGSVILLK (5TAMRA)K-NH2) (SEQ ID NO: 2) by human ADAMTS-5.For the dose res...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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LigandPNGBDBM429688((R)-5-(3-(4-(4- chloro-3,5- dimethoxy- phenyl)pipe...)
Affinity DataIC50:  12.5nMAssay Description:The basis for the assay is the cleavage of the substrate 520 MMP FRET substrate XII by human ADAMTS6.The substrate contains sequence Arg-Pro-Lys-Pro-...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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LigandPNGBDBM429689(5-(3-(4-(4- chloro-3,5- dimethoxy- phenyl)piperidi...)
Affinity DataIC50:  12.5nMAssay Description:The basis for the assay is the cleavage of the substrate 520 MMP FRET substrate XII by human ADAMTS6.The substrate contains sequence Arg-Pro-Lys-Pro-...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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LigandPNGBDBM429691(5-(3-(4-(4- chlorophenyl) piperidin-1- yl)-2-methy...)
Affinity DataIC50:  12.5nMAssay Description:The basis for the assay is the cleavage of the substrate 520 MMP FRET substrate XII by human ADAMTS6.The substrate contains sequence Arg-Pro-Lys-Pro-...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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LigandPNGBDBM429692(5-(3-(4-(3,5- dichlorophenyl) piperidin-1- yl)-2-m...)
Affinity DataIC50:  12.5nMAssay Description:The basis for the assay is the cleavage of the substrate 520 MMP FRET substrate XII by human ADAMTS6.The substrate contains sequence Arg-Pro-Lys-Pro-...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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LigandPNGBDBM429715(5-(3-(4-(4- chloro-3- methoxyl- phenyl)piperidin-1...)
Affinity DataIC50:  12.5nMAssay Description:The basis for the assay is the cleavage of the substrate 520 MMP FRET substrate XII by human ADAMTS6.The substrate contains sequence Arg-Pro-Lys-Pro-...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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LigandPNGBDBM429716(5-(3-(4-(4- chloro-5- methoxy-2- methylphenyl) pip...)
Affinity DataIC50:  12.5nMAssay Description:The basis for the assay is the cleavage of the substrate 520 MMP FRET substrate XII by human ADAMTS6.The substrate contains sequence Arg-Pro-Lys-Pro-...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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LigandPNGBDBM429723(5-(3-(4-(4- chloro-2- methoxyphenyl) piperidin-1- ...)
Affinity DataIC50:  12.5nMAssay Description:The basis for the assay is the cleavage of the substrate 520 MMP FRET substrate XII by human ADAMTS6.The substrate contains sequence Arg-Pro-Lys-Pro-...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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LigandPNGBDBM429724(5-(3-(4-(3,4- difluoro-5- methoxyphenyl) piperidin...)
Affinity DataIC50:  12.5nMAssay Description:The basis for the assay is the cleavage of the substrate 520 MMP FRET substrate XII by human ADAMTS6.The substrate contains sequence Arg-Pro-Lys-Pro-...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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LigandPNGBDBM429725((R)-5-(3-(4-(4- chloro-3- fluoro-5- methoxyphenyl)...)
Affinity DataIC50:  12.5nMAssay Description:The basis for the assay is the cleavage of the substrate 520 MMP FRET substrate XII by human ADAMTS6.The substrate contains sequence Arg-Pro-Lys-Pro-...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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LigandPNGBDBM429726(5-(3-(4-(4- chloro-3- fluoro-5- methoxyphenyl) pip...)
Affinity DataIC50:  12.5nMAssay Description:The basis for the assay is the cleavage of the substrate 520 MMP FRET substrate XII by human ADAMTS6.The substrate contains sequence Arg-Pro-Lys-Pro-...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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LigandPNGBDBM429740((R)-5-(3-(4- (4,5-dichloro- 2- methoxyphenyl) pipe...)
Affinity DataIC50:  12.5nMAssay Description:The basis for the assay is the cleavage of the substrate 520 MMP FRET substrate XII by human ADAMTS6.The substrate contains sequence Arg-Pro-Lys-Pro-...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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LigandPNGBDBM429741(5-(3-(4-(4,5- dichloro-2- methoxyphenyl) piperidin...)
Affinity DataIC50:  12.5nMAssay Description:The basis for the assay is the cleavage of the substrate 520 MMP FRET substrate XII by human ADAMTS6.The substrate contains sequence Arg-Pro-Lys-Pro-...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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LigandPNGBDBM429745((R)-5-(3-(4-(3- chloro-5- methoxyphenyl) piperidin...)
Affinity DataIC50:  12.5nMAssay Description:The basis for the assay is the cleavage of the substrate 520 MMP FRET substrate XII by human ADAMTS6.The substrate contains sequence Arg-Pro-Lys-Pro-...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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LigandPNGBDBM429747((R)-5-(3-(4- (3,4-dichloro-5- methoxyphenyl) piper...)
Affinity DataIC50:  12.5nMAssay Description:The basis for the assay is the cleavage of the substrate 520 MMP FRET substrate XII by human ADAMTS6.The substrate contains sequence Arg-Pro-Lys-Pro-...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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