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Patent code US10550102

Compile Data Set for Download or QSAR
Found 161 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Soluble Guanylate Cyclases


(Homo sapiens (Human))
BDBM430992
PNG
(US10550102, Example 40-3 (-))
Show SMILES CCC[C@H](O)C(=O)N1CCC(CC1)c1ccc(CC2CCc3cccc(c23)-c2cccc(n2)-n2ncc(C(O)=O)c2CC)c(C)c1
Show InChI InChI=1S/C38H44N4O4/c1-4-8-34(43)37(44)41-19-17-25(18-20-41)28-15-14-27(24(3)21-28)22-29-16-13-26-9-6-10-30(36(26)29)32-11-7-12-35(40-32)42-33(5-2)31(23-39-42)38(45)46/h6-7,9-12,14-15,21,23,25,29,34,43H,4-5,8,13,16-20,22H2,1-3H3,(H,45,46)/t29?,34-/m0/s1
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NOVARTIS AG

US Patent


Assay Description
Chinese hamster ovary (CHO) cells overexpressing soluble guanylate cyclase were generated to test the effect of sGC activators in a cellular context....


US Patent US10550102 (2020)


BindingDB Entry DOI: 10.7270/Q2PC34SQ
More data for this
Ligand-Target Pair
Soluble Guanylate Cyclases


(Homo sapiens (Human))
BDBM431006
PNG
(US10550102, Example 43 (-))
Show SMILES Cc1cc2CCC(Nc3ccc(cc3C)C3CCN(CC3)C(=O)C3CC3)c2c(c1)-c1cccc(n1)-n1ncc(C(O)=O)c1C(F)(F)F
Show InChI InChI=1S/C36H36F3N5O3/c1-20-16-25-9-11-30(41-28-10-8-24(18-21(28)2)22-12-14-43(15-13-22)34(45)23-6-7-23)32(25)26(17-20)29-4-3-5-31(42-29)44-33(36(37,38)39)27(19-40-44)35(46)47/h3-5,8,10,16-19,22-23,30,41H,6-7,9,11-15H2,1-2H3,(H,46,47)
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n/an/an/an/a 23n/an/an/an/a



NOVARTIS AG

US Patent


Assay Description
Chinese hamster ovary (CHO) cells overexpressing soluble guanylate cyclase were generated to test the effect of sGC activators in a cellular context....


US Patent US10550102 (2020)


BindingDB Entry DOI: 10.7270/Q2PC34SQ
More data for this
Ligand-Target Pair
Soluble Guanylate Cyclases


(Homo sapiens (Human))
BDBM430673
PNG
(US10550102, Example 7b)
Show SMILES CCOC(=O)c1cnn(c1C)-c1cccc(n1)-c1cccc2CCC(Nc3ccc(cc3C)C3CCN(CC3)C(=O)C3CC3)c12
Show InChI InChI=1S/C37H41N5O3/c1-4-45-37(44)30-22-38-42(24(30)3)34-10-6-9-32(40-34)29-8-5-7-26-13-16-33(35(26)29)39-31-15-14-28(21-23(31)2)25-17-19-41(20-18-25)36(43)27-11-12-27/h5-10,14-15,21-22,25,27,33,39H,4,11-13,16-20H2,1-3H3
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NOVARTIS AG

US Patent


Assay Description
Chinese hamster ovary (CHO) cells overexpressing soluble guanylate cyclase were generated to test the effect of sGC activators in a cellular context....


US Patent US10550102 (2020)


BindingDB Entry DOI: 10.7270/Q2PC34SQ
More data for this
Ligand-Target Pair
Soluble Guanylate Cyclases


(Homo sapiens (Human))
BDBM430679
PNG
(US10550102, Example (-)-8. b))
Show SMILES Cc1cc(ccc1NC1CCc2cccc(c12)-c1cccc(n1)-n1ncc(C(O)=O)c1C(F)(F)F)C1CCN(CC1)C(=O)C1CC1
Show InChI InChI=1S/C35H34F3N5O3/c1-20-18-24(21-14-16-42(17-15-21)33(44)23-8-9-23)11-12-27(20)40-29-13-10-22-4-2-5-25(31(22)29)28-6-3-7-30(41-28)43-32(35(36,37)38)26(19-39-43)34(45)46/h2-7,11-12,18-19,21,23,29,40H,8-10,13-17H2,1H3,(H,45,46)
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n/an/an/an/a 53n/an/an/an/a



NOVARTIS AG

US Patent


Assay Description
Chinese hamster ovary (CHO) cells overexpressing soluble guanylate cyclase were generated to test the effect of sGC activators in a cellular context....


US Patent US10550102 (2020)


BindingDB Entry DOI: 10.7270/Q2PC34SQ
More data for this
Ligand-Target Pair
Soluble Guanylate Cyclases


(Homo sapiens (Human))
BDBM430866
PNG
(US10550102, Example 10b)
Show SMILES CCOC(=O)c1cnn(c1CC)-c1cccc(n1)-c1cccc2CCC(Nc3ccc(cc3C)C3CCN(CC3)C(=O)C3CC3)c12
Show InChI InChI=1S/C38H43N5O3/c1-4-34-30(38(45)46-5-2)23-39-43(34)35-11-7-10-32(41-35)29-9-6-8-26-14-17-33(36(26)29)40-31-16-15-28(22-24(31)3)25-18-20-42(21-19-25)37(44)27-12-13-27/h6-11,15-16,22-23,25,27,33,40H,4-5,12-14,17-21H2,1-3H3
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NOVARTIS AG

US Patent


Assay Description
Chinese hamster ovary (CHO) cells overexpressing soluble guanylate cyclase were generated to test the effect of sGC activators in a cellular context....


US Patent US10550102 (2020)


BindingDB Entry DOI: 10.7270/Q2PC34SQ
More data for this
Ligand-Target Pair
Soluble Guanylate Cyclases


(Homo sapiens (Human))
BDBM430868
PNG
(US10550102, Example 11-1)
Show SMILES Cc1cc2CCC(Nc3ccc(cc3C)C3CCN(CC3)C(=O)C3CC3)c2c(c1)-c1cccc(n1)-n1ncc(C(O)=O)c1C(F)(F)F
Show InChI InChI=1S/C36H36F3N5O3/c1-20-16-25-9-11-30(41-28-10-8-24(18-21(28)2)22-12-14-43(15-13-22)34(45)23-6-7-23)32(25)26(17-20)29-4-3-5-31(42-29)44-33(36(37,38)39)27(19-40-44)35(46)47/h3-5,8,10,16-19,22-23,30,41H,6-7,9,11-15H2,1-2H3,(H,46,47)
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NOVARTIS AG

US Patent


Assay Description
Chinese hamster ovary (CHO) cells overexpressing soluble guanylate cyclase were generated to test the effect of sGC activators in a cellular context....


US Patent US10550102 (2020)


BindingDB Entry DOI: 10.7270/Q2PC34SQ
More data for this
Ligand-Target Pair
Soluble Guanylate Cyclases


(Homo sapiens (Human))
BDBM430875
PNG
(US10550102, Example 5-6)
Show SMILES Cc1c(cnn1-c1cccc(n1)-c1cccc2CC[C@H](Oc3ccc(cc3C)C3CCN(CC3)C(=O)C3CC3)c12)C(O)=O
Show InChI InChI=1S/C35H36N4O4/c1-21-19-26(23-15-17-38(18-16-23)34(40)25-9-10-25)12-13-30(21)43-31-14-11-24-5-3-6-27(33(24)31)29-7-4-8-32(37-29)39-22(2)28(20-36-39)35(41)42/h3-8,12-13,19-20,23,25,31H,9-11,14-18H2,1-2H3,(H,41,42)/t31-/m0/s1
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NOVARTIS AG

US Patent


Assay Description
Chinese hamster ovary (CHO) cells overexpressing soluble guanylate cyclase were generated to test the effect of sGC activators in a cellular context....


US Patent US10550102 (2020)


BindingDB Entry DOI: 10.7270/Q2PC34SQ
More data for this
Ligand-Target Pair
Soluble Guanylate Cyclases


(Homo sapiens (Human))
BDBM430883
PNG
(US10550102, Example 6. b). (+))
Show SMILES Cc1cc(ccc1NC1CCc2cccc(c12)-c1cccc(c1)-n1ncc(C(O)=O)c1C(F)(F)F)C1CCN(CC1)C(=O)C1CC1
Show InChI InChI=1S/C36H35F3N4O3/c1-21-18-25(22-14-16-42(17-15-22)34(44)24-8-9-24)11-12-30(21)41-31-13-10-23-4-3-7-28(32(23)31)26-5-2-6-27(19-26)43-33(36(37,38)39)29(20-40-43)35(45)46/h2-7,11-12,18-20,22,24,31,41H,8-10,13-17H2,1H3,(H,45,46)
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NOVARTIS AG

US Patent


Assay Description
Chinese hamster ovary (CHO) cells overexpressing soluble guanylate cyclase were generated to test the effect of sGC activators in a cellular context....


US Patent US10550102 (2020)


BindingDB Entry DOI: 10.7270/Q2PC34SQ
More data for this
Ligand-Target Pair
Soluble Guanylate Cyclases


(Homo sapiens (Human))
BDBM430890
PNG
(US10550102, Example (+)-46-1)
Show SMILES CC(C)C(=O)N1CCC(CC1)c1ccc(NC2CCc3cccc(c23)-c2cccc(n2)-n2ncc(C(O)=O)c2C)c(C)c1
Show InChI InChI=1S/C35H39N5O3/c1-21(2)34(41)39-17-15-24(16-18-39)26-12-13-29(22(3)19-26)37-31-14-11-25-7-5-8-27(33(25)31)30-9-6-10-32(38-30)40-23(4)28(20-36-40)35(42)43/h5-10,12-13,19-21,24,31,37H,11,14-18H2,1-4H3,(H,42,43)
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NOVARTIS AG

US Patent


Assay Description
Chinese hamster ovary (CHO) cells overexpressing soluble guanylate cyclase were generated to test the effect of sGC activators in a cellular context....


US Patent US10550102 (2020)


BindingDB Entry DOI: 10.7270/Q2PC34SQ
More data for this
Ligand-Target Pair
Soluble Guanylate Cyclases


(Homo sapiens (Human))
BDBM430892
PNG
(US10550102, Example (-)-46-1)
Show SMILES CC(C)C(=O)N1CCC(CC1)c1ccc(NC2CCc3cccc(c23)-c2cccc(n2)-n2ncc(C(O)=O)c2C)c(C)c1
Show InChI InChI=1S/C35H39N5O3/c1-21(2)34(41)39-17-15-24(16-18-39)26-12-13-29(22(3)19-26)37-31-14-11-25-7-5-8-27(33(25)31)30-9-6-10-32(38-30)40-23(4)28(20-36-40)35(42)43/h5-10,12-13,19-21,24,31,37H,11,14-18H2,1-4H3,(H,42,43)
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NOVARTIS AG

US Patent


Assay Description
Chinese hamster ovary (CHO) cells overexpressing soluble guanylate cyclase were generated to test the effect of sGC activators in a cellular context....


US Patent US10550102 (2020)


BindingDB Entry DOI: 10.7270/Q2PC34SQ
More data for this
Ligand-Target Pair
Soluble Guanylate Cyclases


(Homo sapiens (Human))
BDBM430915
PNG
(US10550102, Example 22a)
Show SMILES CCc1c(cnn1-c1cccc(n1)-c1cccc2CC(C)N(Cc3ccc(C4CCN(CC4)C(=O)C4CC4)c(CC)c3)c12)C(O)=O
Show InChI InChI=1S/C38H43N5O3/c1-4-26-21-25(12-15-30(26)27-16-18-41(19-17-27)37(44)28-13-14-28)23-42-24(3)20-29-8-6-9-31(36(29)42)33-10-7-11-35(40-33)43-34(5-2)32(22-39-43)38(45)46/h6-12,15,21-22,24,27-28H,4-5,13-14,16-20,23H2,1-3H3,(H,45,46)
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NOVARTIS AG

US Patent


Assay Description
Chinese hamster ovary (CHO) cells overexpressing soluble guanylate cyclase were generated to test the effect of sGC activators in a cellular context....


US Patent US10550102 (2020)


BindingDB Entry DOI: 10.7270/Q2PC34SQ
More data for this
Ligand-Target Pair
Soluble Guanylate Cyclases


(Homo sapiens (Human))
BDBM430918
PNG
(US10550102, Example 48b)
Show SMILES CCOC(=O)c1cnn(c1CC)-c1cccc(n1)-c1cccc2CCC(Nc3ccc(C4CCNCC4)c(CC)c3)c12
Show InChI InChI=1S/C35H41N5O2/c1-4-23-21-26(14-15-27(23)24-17-19-36-20-18-24)38-31-16-13-25-9-7-10-28(34(25)31)30-11-8-12-33(39-30)40-32(5-2)29(22-37-40)35(41)42-6-3/h7-12,14-15,21-22,24,31,36,38H,4-6,13,16-20H2,1-3H3
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NOVARTIS AG

US Patent


Assay Description
Chinese hamster ovary (CHO) cells overexpressing soluble guanylate cyclase were generated to test the effect of sGC activators in a cellular context....


US Patent US10550102 (2020)


BindingDB Entry DOI: 10.7270/Q2PC34SQ
More data for this
Ligand-Target Pair
Soluble Guanylate Cyclases


(Homo sapiens (Human))
BDBM430923
PNG
(Example 25-A. Ethyl 1-(6-(1-((1,2,3,4-tetrahydrois...)
Show SMILES OC(=O)c1cnn(c1C(F)(F)F)-c1cccc(n1)-c1cccc2CCN(Cc3ccc4CN(Cc5ccccn5)CCc4c3)c12
Show InChI InChI=1S/C34H29F3N6O2/c35-34(36,37)32-28(33(44)45)18-39-43(32)30-9-4-8-29(40-30)27-7-3-5-23-13-16-42(31(23)27)19-22-10-11-25-20-41(15-12-24(25)17-22)21-26-6-1-2-14-38-26/h1-11,14,17-18H,12-13,15-16,19-21H2,(H,44,45)
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NOVARTIS AG

US Patent


Assay Description
Chinese hamster ovary (CHO) cells overexpressing soluble guanylate cyclase were generated to test the effect of sGC activators in a cellular context....


US Patent US10550102 (2020)


BindingDB Entry DOI: 10.7270/Q2PC34SQ
More data for this
Ligand-Target Pair
Soluble Guanylate Cyclases


(Homo sapiens (Human))
BDBM430974
PNG
(US10550102, Example 38-2 (+))
Show SMILES CCc1cc(CC2CCc3cccc(c23)-c2cccc(n2)-n2ncc(C(O)=O)c2C)ccc1C1CCN(CC1)C(=O)C1CC1
Show InChI InChI=1S/C37H40N4O3/c1-3-25-20-24(10-15-30(25)26-16-18-40(19-17-26)36(42)28-12-13-28)21-29-14-11-27-6-4-7-31(35(27)29)33-8-5-9-34(39-33)41-23(2)32(22-38-41)37(43)44/h4-10,15,20,22,26,28-29H,3,11-14,16-19,21H2,1-2H3,(H,43,44)
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NOVARTIS AG

US Patent


Assay Description
Chinese hamster ovary (CHO) cells overexpressing soluble guanylate cyclase were generated to test the effect of sGC activators in a cellular context....


US Patent US10550102 (2020)


BindingDB Entry DOI: 10.7270/Q2PC34SQ
More data for this
Ligand-Target Pair
Soluble Guanylate Cyclases


(Homo sapiens (Human))
BDBM430975
PNG
(Example 56-A. a). (+-)-tert-Butyl 4-(4-((7-(3-(4-(...)
Show SMILES Cc1cc(ccc1NC1CCc2cccc(c12)-c1cccc(c1)-n1ncc(C(O)=O)c1C(F)(F)F)C1CCN(CC1)C(=O)CO
Show InChI InChI=1S/C34H33F3N4O4/c1-20-16-23(21-12-14-40(15-13-21)30(43)19-42)9-10-28(20)39-29-11-8-22-4-3-7-26(31(22)29)24-5-2-6-25(17-24)41-32(34(35,36)37)27(18-38-41)33(44)45/h2-7,9-10,16-18,21,29,39,42H,8,11-15,19H2,1H3,(H,44,45)
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NOVARTIS AG

US Patent


Assay Description
Chinese hamster ovary (CHO) cells overexpressing soluble guanylate cyclase were generated to test the effect of sGC activators in a cellular context....


US Patent US10550102 (2020)


BindingDB Entry DOI: 10.7270/Q2PC34SQ
More data for this
Ligand-Target Pair
Soluble Guanylate Cyclases


(Homo sapiens (Human))
BDBM430977
PNG
(US10550102, Example 57)
Show SMILES Cc1cc(ccc1NC1CCc2cccc(c12)-c1cccc(n1)-n1ncc(C(O)=O)c1CC(F)(F)F)C1CCN(CC1)C(=O)C1CC1
Show InChI InChI=1S/C36H36F3N5O3/c1-21-18-25(22-14-16-43(17-15-22)34(45)24-8-9-24)11-12-28(21)41-30-13-10-23-4-2-5-26(33(23)30)29-6-3-7-32(42-29)44-31(19-36(37,38)39)27(20-40-44)35(46)47/h2-7,11-12,18,20,22,24,30,41H,8-10,13-17,19H2,1H3,(H,46,47)
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NOVARTIS AG

US Patent


Assay Description
Chinese hamster ovary (CHO) cells overexpressing soluble guanylate cyclase were generated to test the effect of sGC activators in a cellular context....


US Patent US10550102 (2020)


BindingDB Entry DOI: 10.7270/Q2PC34SQ
More data for this
Ligand-Target Pair
Soluble Guanylate Cyclases


(Homo sapiens (Human))
BDBM430984
PNG
(US10550102, Example 40-1 (-))
Show SMILES CCC[C@H](O)C(=O)N1CCC(CC1)c1ccc(CC2CCc3cccc(c23)-c2cccc(n2)-n2ncc(C(O)=O)c2CC)cc1CC
Show InChI InChI=1S/C39H46N4O4/c1-4-9-35(44)38(45)42-20-18-27(19-21-42)30-17-14-25(22-26(30)5-2)23-29-16-15-28-10-7-11-31(37(28)29)33-12-8-13-36(41-33)43-34(6-3)32(24-40-43)39(46)47/h7-8,10-14,17,22,24,27,29,35,44H,4-6,9,15-16,18-21,23H2,1-3H3,(H,46,47)/t29?,35-/m0/s1
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NOVARTIS AG

US Patent


Assay Description
Chinese hamster ovary (CHO) cells overexpressing soluble guanylate cyclase were generated to test the effect of sGC activators in a cellular context....


US Patent US10550102 (2020)


BindingDB Entry DOI: 10.7270/Q2PC34SQ
More data for this
Ligand-Target Pair
Soluble Guanylate Cyclases


(Homo sapiens (Human))
BDBM430988
PNG
(US10550102, Example 40-2 (-))
Show SMILES CCc1c(cnn1-c1cccc(n1)-c1cccc2CCC(Cc3ccc(cc3C)C3CCN(CC3)C(=O)[C@H](C)O)c12)C(O)=O
Show InChI InChI=1S/C36H40N4O4/c1-4-32-30(36(43)44)21-37-40(32)33-10-6-9-31(38-33)29-8-5-7-25-11-14-28(34(25)29)20-26-12-13-27(19-22(26)2)24-15-17-39(18-16-24)35(42)23(3)41/h5-10,12-13,19,21,23-24,28,41H,4,11,14-18,20H2,1-3H3,(H,43,44)/t23-,28?/m0/s1
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NOVARTIS AG

US Patent


Assay Description
Chinese hamster ovary (CHO) cells overexpressing soluble guanylate cyclase were generated to test the effect of sGC activators in a cellular context....


US Patent US10550102 (2020)


BindingDB Entry DOI: 10.7270/Q2PC34SQ
More data for this
Ligand-Target Pair
Soluble Guanylate Cyclases


(Homo sapiens (Human))
BDBM430995
PNG
(US10550102, Example 63b)
Show SMILES CCOC(=O)c1cnn(c1CC)-c1cccc(n1)-c1cccc2CCC(Nc3ccc(C4CCN(CC4)C(=O)C4CC4)c(CC)n3)c12
Show InChI InChI=1S/C38H44N6O3/c1-4-30-27(24-19-21-43(22-20-24)37(45)26-13-14-26)16-18-34(40-30)41-32-17-15-25-9-7-10-28(36(25)32)31-11-8-12-35(42-31)44-33(5-2)29(23-39-44)38(46)47-6-3/h7-12,16,18,23-24,26,32H,4-6,13-15,17,19-22H2,1-3H3,(H,40,41)
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NOVARTIS AG

US Patent


Assay Description
Chinese hamster ovary (CHO) cells overexpressing soluble guanylate cyclase were generated to test the effect of sGC activators in a cellular context....


US Patent US10550102 (2020)


BindingDB Entry DOI: 10.7270/Q2PC34SQ
More data for this
Ligand-Target Pair
Soluble Guanylate Cyclases


(Homo sapiens (Human))
BDBM430997
PNG
(US10550102, Example 64-1)
Show SMILES CCc1c(cnn1-c1cccc(n1)-c1cccc2CC[C@H](Oc3ccc(C4CCN(CC4)C(=O)OCc4ccccc4)c(CC)c3)c12)C(O)=O
Show InChI InChI=1S/C41H42N4O5/c1-3-28-24-31(17-18-32(28)29-20-22-44(23-21-29)41(48)49-26-27-10-6-5-7-11-27)50-37-19-16-30-12-8-13-33(39(30)37)35-14-9-15-38(43-35)45-36(4-2)34(25-42-45)40(46)47/h5-15,17-18,24-25,29,37H,3-4,16,19-23,26H2,1-2H3,(H,46,47)/t37-/m0/s1
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NOVARTIS AG

US Patent


Assay Description
Chinese hamster ovary (CHO) cells overexpressing soluble guanylate cyclase were generated to test the effect of sGC activators in a cellular context....


US Patent US10550102 (2020)


BindingDB Entry DOI: 10.7270/Q2PC34SQ
More data for this
Ligand-Target Pair
Soluble Guanylate Cyclases


(Homo sapiens (Human))
BDBM431003
PNG
(US10550102, Example 64-4)
Show SMILES CCCOC(=O)N1CCC(CC1)c1ccc(O[C@H]2CCc3cccc(c23)-c2cccc(n2)-n2ncc(C(O)=O)c2CC)cc1CC
Show InChI InChI=1S/C37H42N4O5/c1-4-21-45-37(44)40-19-17-25(18-20-40)28-15-14-27(22-24(28)5-2)46-33-16-13-26-9-7-10-29(35(26)33)31-11-8-12-34(39-31)41-32(6-3)30(23-38-41)36(42)43/h7-12,14-15,22-23,25,33H,4-6,13,16-21H2,1-3H3,(H,42,43)/t33-/m0/s1
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NOVARTIS AG

US Patent


Assay Description
Chinese hamster ovary (CHO) cells overexpressing soluble guanylate cyclase were generated to test the effect of sGC activators in a cellular context....


US Patent US10550102 (2020)


BindingDB Entry DOI: 10.7270/Q2PC34SQ
More data for this
Ligand-Target Pair
Soluble Guanylate Cyclases


(Homo sapiens (Human))
BDBM431005
PNG
(US10550102, Example 64-5)
Show SMILES CCc1c(cnn1-c1cccc(n1)-c1cccc2CC[C@H](Oc3ccc(C4CCN(CC4)C(=O)OCC=C)c(CC)c3)c12)C(O)=O
Show InChI InChI=1S/C37H40N4O5/c1-4-21-45-37(44)40-19-17-25(18-20-40)28-15-14-27(22-24(28)5-2)46-33-16-13-26-9-7-10-29(35(26)33)31-11-8-12-34(39-31)41-32(6-3)30(23-38-41)36(42)43/h4,7-12,14-15,22-23,25,33H,1,5-6,13,16-21H2,2-3H3,(H,42,43)/t33-/m0/s1
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NOVARTIS AG

US Patent


Assay Description
Chinese hamster ovary (CHO) cells overexpressing soluble guanylate cyclase were generated to test the effect of sGC activators in a cellular context....


US Patent US10550102 (2020)


BindingDB Entry DOI: 10.7270/Q2PC34SQ
More data for this
Ligand-Target Pair
Soluble Guanylate Cyclases


(Homo sapiens (Human))
BDBM431011
PNG
(US10550102, Example 64-8)
Show SMILES CCc1c(cnn1-c1cccc(n1)-c1cccc2CC[C@H](Oc3ccc(C4CCN(CC4)S(C)(=O)=O)c(CC)c3)c12)C(O)=O
Show InChI InChI=1S/C34H38N4O5S/c1-4-22-20-25(13-14-26(22)23-16-18-37(19-17-23)44(3,41)42)43-31-15-12-24-8-6-9-27(33(24)31)29-10-7-11-32(36-29)38-30(5-2)28(21-35-38)34(39)40/h6-11,13-14,20-21,23,31H,4-5,12,15-19H2,1-3H3,(H,39,40)/t31-/m0/s1
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NOVARTIS AG

US Patent


Assay Description
Chinese hamster ovary (CHO) cells overexpressing soluble guanylate cyclase were generated to test the effect of sGC activators in a cellular context....


US Patent US10550102 (2020)


BindingDB Entry DOI: 10.7270/Q2PC34SQ
More data for this
Ligand-Target Pair
Soluble Guanylate Cyclases


(Homo sapiens (Human))
BDBM430880
PNG
(Example 14-A. tert-Butyl 4-(4-((7-(6-(4-(ethoxycar...)
Show SMILES CCc1c(cnn1-c1cccc(n1)-c1cccc2CCN(Cc3ccc(C4CCN(CC4)C(=O)C4CC4)c(CC)c3)c12)C(O)=O
Show InChI InChI=1S/C37H41N5O3/c1-3-25-21-24(11-14-29(25)26-15-18-40(19-16-26)36(43)28-12-13-28)23-41-20-17-27-7-5-8-30(35(27)41)32-9-6-10-34(39-32)42-33(4-2)31(22-38-42)37(44)45/h5-11,14,21-22,26,28H,3-4,12-13,15-20,23H2,1-2H3,(H,44,45)
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NOVARTIS AG

US Patent


Assay Description
Chinese hamster ovary (CHO) cells overexpressing soluble guanylate cyclase were generated to test the effect of sGC activators in a cellular context....


US Patent US10550102 (2020)


BindingDB Entry DOI: 10.7270/Q2PC34SQ
More data for this
Ligand-Target Pair
Soluble Guanylate Cyclases


(Homo sapiens (Human))
BDBM430882
PNG
(Example 15-A. Ethyl 1-(6-(1-(3-ethyl-4-1-(2,2,2-tr...)
Show SMILES CCc1cc(CN2CCc3cccc(c23)-c2cccc(n2)-n2ncc(C(O)=O)c2C(F)(F)F)ccc1C1CCN(CC(F)(F)F)CC1
Show InChI InChI=1S/C34H33F6N5O2/c1-2-22-17-21(9-10-25(22)23-11-14-43(15-12-23)20-33(35,36)37)19-44-16-13-24-5-3-6-26(30(24)44)28-7-4-8-29(42-28)45-31(34(38,39)40)27(18-41-45)32(46)47/h3-10,17-18,23H,2,11-16,19-20H2,1H3,(H,46,47)
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NOVARTIS AG

US Patent


Assay Description
Chinese hamster ovary (CHO) cells overexpressing soluble guanylate cyclase were generated to test the effect of sGC activators in a cellular context....


US Patent US10550102 (2020)


BindingDB Entry DOI: 10.7270/Q2PC34SQ
More data for this
Ligand-Target Pair
Soluble Guanylate Cyclases


(Homo sapiens (Human))
BDBM430888
PNG
(US10550102, Example 45b)
Show SMILES CCOC(=O)c1cnn(c1C)-c1cccc(n1)-c1cccc2CCC(Nc3ccc(cc3C)C3CCN(CC3)C(=O)OC(C)(C)C)c12
Show InChI InChI=1S/C38H45N5O4/c1-7-46-36(44)30-23-39-43(25(30)3)34-13-9-12-32(41-34)29-11-8-10-27-14-17-33(35(27)29)40-31-16-15-28(22-24(31)2)26-18-20-42(21-19-26)37(45)47-38(4,5)6/h8-13,15-16,22-23,26,33,40H,7,14,17-21H2,1-6H3
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NOVARTIS AG

US Patent


Assay Description
Chinese hamster ovary (CHO) cells overexpressing soluble guanylate cyclase were generated to test the effect of sGC activators in a cellular context....


US Patent US10550102 (2020)


BindingDB Entry DOI: 10.7270/Q2PC34SQ
More data for this
Ligand-Target Pair
Soluble Guanylate Cyclases


(Homo sapiens (Human))
BDBM430896
PNG
(US10550102, Example (-)-46-2)
Show SMILES CCC(=O)N1CCC(CC1)c1ccc(NC2CCc3cccc(c23)-c2cccc(n2)-n2ncc(C(O)=O)c2C)c(C)c1
Show InChI InChI=1S/C34H37N5O3/c1-4-32(40)38-17-15-23(16-18-38)25-12-13-28(21(2)19-25)36-30-14-11-24-7-5-8-26(33(24)30)29-9-6-10-31(37-29)39-22(3)27(20-35-39)34(41)42/h5-10,12-13,19-20,23,30,36H,4,11,14-18H2,1-3H3,(H,41,42)
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NOVARTIS AG

US Patent


Assay Description
Chinese hamster ovary (CHO) cells overexpressing soluble guanylate cyclase were generated to test the effect of sGC activators in a cellular context....


US Patent US10550102 (2020)


BindingDB Entry DOI: 10.7270/Q2PC34SQ
More data for this
Ligand-Target Pair
Soluble Guanylate Cyclases


(Homo sapiens (Human))
BDBM430899
PNG
(US10550102, Example (+)-20-1)
Show SMILES CCc1c(cnn1-c1cccc(n1)-c1cccc2C(C)CN(Cc3ccc(C4CCN(CC4)C(=O)C4CC4)c(CC)c3)c12)C(O)=O
Show InChI InChI=1S/C38H43N5O3/c1-4-26-20-25(12-15-30(26)27-16-18-41(19-17-27)37(44)28-13-14-28)23-42-22-24(3)29-8-6-9-31(36(29)42)33-10-7-11-35(40-33)43-34(5-2)32(21-39-43)38(45)46/h6-12,15,20-21,24,27-28H,4-5,13-14,16-19,22-23H2,1-3H3,(H,45,46)
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NOVARTIS AG

US Patent


Assay Description
Chinese hamster ovary (CHO) cells overexpressing soluble guanylate cyclase were generated to test the effect of sGC activators in a cellular context....


US Patent US10550102 (2020)


BindingDB Entry DOI: 10.7270/Q2PC34SQ
More data for this
Ligand-Target Pair
Soluble Guanylate Cyclases


(Homo sapiens (Human))
BDBM430900
PNG
(US10550102, Example (-)-46-3)
Show SMILES Cc1c(cnn1-c1cccc(n1)-c1cccc2CCC(Nc3ccc(cc3C)C3CCN(CC3)C(=O)CC3CC3)c12)C(O)=O
Show InChI InChI=1S/C36H39N5O3/c1-22-19-27(25-15-17-40(18-16-25)34(42)20-24-9-10-24)12-13-30(22)38-32-14-11-26-5-3-6-28(35(26)32)31-7-4-8-33(39-31)41-23(2)29(21-37-41)36(43)44/h3-8,12-13,19,21,24-25,32,38H,9-11,14-18,20H2,1-2H3,(H,43,44)
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NOVARTIS AG

US Patent


Assay Description
Chinese hamster ovary (CHO) cells overexpressing soluble guanylate cyclase were generated to test the effect of sGC activators in a cellular context....


US Patent US10550102 (2020)


BindingDB Entry DOI: 10.7270/Q2PC34SQ
More data for this
Ligand-Target Pair
Soluble Guanylate Cyclases


(Homo sapiens (Human))
BDBM430904
PNG
(US10550102, Example (-) or (+)-46-4)
Show SMILES Cc1c(cnn1-c1cccc(n1)-c1cccc2CCC(Nc3ccc(C4CCN(CC4)C(=O)CC4CC4)c(F)c3C)c12)C(O)=O
Show InChI InChI=1S/C36H38FN5O3/c1-21-29(14-12-26(35(21)37)24-15-17-41(18-16-24)33(43)19-23-9-10-23)39-31-13-11-25-5-3-6-27(34(25)31)30-7-4-8-32(40-30)42-22(2)28(20-38-42)36(44)45/h3-8,12,14,20,23-24,31,39H,9-11,13,15-19H2,1-2H3,(H,44,45)
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NOVARTIS AG

US Patent


Assay Description
Chinese hamster ovary (CHO) cells overexpressing soluble guanylate cyclase were generated to test the effect of sGC activators in a cellular context....


US Patent US10550102 (2020)


BindingDB Entry DOI: 10.7270/Q2PC34SQ
More data for this
Ligand-Target Pair
Soluble Guanylate Cyclases


(Homo sapiens (Human))
BDBM430946
PNG
(US10550102, Example 52-5)
Show SMILES COCCOC(=O)N1CCC(CC1)c1ccc(NC2CCc3cccc(c23)-c2cccc(n2)-n2ncc(C(O)=O)c2C)c(C)c1
Show InChI InChI=1S/C35H39N5O5/c1-22-20-26(24-14-16-39(17-15-24)35(43)45-19-18-44-3)11-12-29(22)37-31-13-10-25-6-4-7-27(33(25)31)30-8-5-9-32(38-30)40-23(2)28(21-36-40)34(41)42/h4-9,11-12,20-21,24,31,37H,10,13-19H2,1-3H3,(H,41,42)
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NOVARTIS AG

US Patent


Assay Description
Chinese hamster ovary (CHO) cells overexpressing soluble guanylate cyclase were generated to test the effect of sGC activators in a cellular context....


US Patent US10550102 (2020)


BindingDB Entry DOI: 10.7270/Q2PC34SQ
More data for this
Ligand-Target Pair
Soluble Guanylate Cyclases


(Homo sapiens (Human))
BDBM430954
PNG
(US10550102, Example 35b)
Show SMILES CCOC(=O)c1cnn(c1C)-c1cccc(n1)-c1cccc2OCC(Nc3ccc(cc3C)C3CCN(CC3)C(=O)OC(C)(C)C)c12
Show InChI InChI=1S/C37H43N5O5/c1-7-45-35(43)28-21-38-42(24(28)3)33-13-9-11-30(40-33)27-10-8-12-32-34(27)31(22-46-32)39-29-15-14-26(20-23(29)2)25-16-18-41(19-17-25)36(44)47-37(4,5)6/h8-15,20-21,25,31,39H,7,16-19,22H2,1-6H3
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NOVARTIS AG

US Patent


Assay Description
Chinese hamster ovary (CHO) cells overexpressing soluble guanylate cyclase were generated to test the effect of sGC activators in a cellular context....


US Patent US10550102 (2020)


BindingDB Entry DOI: 10.7270/Q2PC34SQ
More data for this
Ligand-Target Pair
Soluble Guanylate Cyclases


(Homo sapiens (Human))
BDBM430955
PNG
(US10550102, Example (+)-53-2)
Show SMILES CCc1c(cnn1-c1cccc(n1)-c1cccc2CCC(Nc3ccc(C4CCN(CC4)C(=O)CC4CC4)c(CC)c3)c12)C(O)=O
Show InChI InChI=1S/C38H43N5O3/c1-3-25-22-28(14-15-29(25)26-17-19-42(20-18-26)36(44)21-24-11-12-24)40-33-16-13-27-7-5-8-30(37(27)33)32-9-6-10-35(41-32)43-34(4-2)31(23-39-43)38(45)46/h5-10,14-15,22-24,26,33,40H,3-4,11-13,16-21H2,1-2H3,(H,45,46)
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NOVARTIS AG

US Patent


Assay Description
Chinese hamster ovary (CHO) cells overexpressing soluble guanylate cyclase were generated to test the effect of sGC activators in a cellular context....


US Patent US10550102 (2020)


BindingDB Entry DOI: 10.7270/Q2PC34SQ
More data for this
Ligand-Target Pair
Soluble Guanylate Cyclases


(Homo sapiens (Human))
BDBM430971
PNG
(US10550102, Example 55-1 (+))
Show SMILES CCc1cc(CC2CCc3cccc(c23)-c2cccc(c2)-n2ncc(C(O)=O)c2C)ccc1C1CCN(CC1)C(=O)C1CC1
Show InChI InChI=1S/C38H41N3O3/c1-3-26-20-25(10-15-33(26)27-16-18-40(19-17-27)37(42)29-12-13-29)21-31-14-11-28-6-5-9-34(36(28)31)30-7-4-8-32(22-30)41-24(2)35(23-39-41)38(43)44/h4-10,15,20,22-23,27,29,31H,3,11-14,16-19,21H2,1-2H3,(H,43,44)
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NOVARTIS AG

US Patent


Assay Description
Chinese hamster ovary (CHO) cells overexpressing soluble guanylate cyclase were generated to test the effect of sGC activators in a cellular context....


US Patent US10550102 (2020)


BindingDB Entry DOI: 10.7270/Q2PC34SQ
More data for this
Ligand-Target Pair
Soluble Guanylate Cyclases


(Homo sapiens (Human))
BDBM430980
PNG
(US10550102, Example 39. b). (-))
Show SMILES CCc1c(cnn1-c1cccc(n1)-c1cccc2CCC(Cc3ccc(C4CCN(CC4)C(=O)[C@H](C)O)c(CC)c3)c12)C(O)=O
Show InChI InChI=1S/C37H42N4O4/c1-4-25-20-24(12-15-29(25)26-16-18-40(19-17-26)36(43)23(3)42)21-28-14-13-27-8-6-9-30(35(27)28)32-10-7-11-34(39-32)41-33(5-2)31(22-38-41)37(44)45/h6-12,15,20,22-23,26,28,42H,4-5,13-14,16-19,21H2,1-3H3,(H,44,45)/t23-,28?/m0/s1
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n/an/an/an/a 1n/an/an/an/a



NOVARTIS AG

US Patent


Assay Description
Chinese hamster ovary (CHO) cells overexpressing soluble guanylate cyclase were generated to test the effect of sGC activators in a cellular context....


US Patent US10550102 (2020)


BindingDB Entry DOI: 10.7270/Q2PC34SQ
More data for this
Ligand-Target Pair
Soluble Guanylate Cyclases


(Homo sapiens (Human))
BDBM430982
PNG
(US10550102, Example 39. b). (+))
Show SMILES CCc1c(cnn1-c1cccc(n1)-c1cccc2CCC(Cc3ccc(C4CCN(CC4)C(=O)[C@H](C)O)c(CC)c3)c12)C(O)=O
Show InChI InChI=1S/C37H42N4O4/c1-4-25-20-24(12-15-29(25)26-16-18-40(19-17-26)36(43)23(3)42)21-28-14-13-27-8-6-9-30(35(27)28)32-10-7-11-34(39-32)41-33(5-2)31(22-38-41)37(44)45/h6-12,15,20,22-23,26,28,42H,4-5,13-14,16-19,21H2,1-3H3,(H,44,45)/t23-,28?/m0/s1
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NOVARTIS AG

US Patent


Assay Description
Chinese hamster ovary (CHO) cells overexpressing soluble guanylate cyclase were generated to test the effect of sGC activators in a cellular context....


US Patent US10550102 (2020)


BindingDB Entry DOI: 10.7270/Q2PC34SQ
More data for this
Ligand-Target Pair
Soluble Guanylate Cyclases


(Homo sapiens (Human))
BDBM430983
PNG
(Example 59-A. (+-)-Ethyl 5-methyl-1-(6-(3-((2-meth...)
Show SMILES CCOC(=O)c1cnn(c1C)-c1cccc(n1)-c1cccc2CCC(Nc3ccc(cc3C)C3CCN(CC3)c3ccccn3)c12
Show InChI InChI=1S/C38H40N6O2/c1-4-46-38(45)31-24-40-44(26(31)3)36-13-8-11-33(42-36)30-10-7-9-28-14-17-34(37(28)30)41-32-16-15-29(23-25(32)2)27-18-21-43(22-19-27)35-12-5-6-20-39-35/h5-13,15-16,20,23-24,27,34,41H,4,14,17-19,21-22H2,1-3H3
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n/an/an/an/a 1n/an/an/an/a



NOVARTIS AG

US Patent


Assay Description
Chinese hamster ovary (CHO) cells overexpressing soluble guanylate cyclase were generated to test the effect of sGC activators in a cellular context....


US Patent US10550102 (2020)


BindingDB Entry DOI: 10.7270/Q2PC34SQ
More data for this
Ligand-Target Pair
Soluble Guanylate Cyclases


(Homo sapiens (Human))
BDBM430986
PNG
(US10550102, Example 40-1 (+))
Show SMILES CCC[C@H](O)C(=O)N1CCC(CC1)c1ccc(CC2CCc3cccc(c23)-c2cccc(n2)-n2ncc(C(O)=O)c2CC)cc1CC
Show InChI InChI=1S/C39H46N4O4/c1-4-9-35(44)38(45)42-20-18-27(19-21-42)30-17-14-25(22-26(30)5-2)23-29-16-15-28-10-7-11-31(37(28)29)33-12-8-13-36(41-33)43-34(6-3)32(24-40-43)39(46)47/h7-8,10-14,17,22,24,27,29,35,44H,4-6,9,15-16,18-21,23H2,1-3H3,(H,46,47)/t29?,35-/m0/s1
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NOVARTIS AG

US Patent


Assay Description
Chinese hamster ovary (CHO) cells overexpressing soluble guanylate cyclase were generated to test the effect of sGC activators in a cellular context....


US Patent US10550102 (2020)


BindingDB Entry DOI: 10.7270/Q2PC34SQ
More data for this
Ligand-Target Pair
Soluble Guanylate Cyclases


(Homo sapiens (Human))
BDBM430990
PNG
(US10550102, Example 40-2 (+))
Show SMILES CCc1c(cnn1-c1cccc(n1)-c1cccc2CCC(Cc3ccc(cc3C)C3CCN(CC3)C(=O)[C@H](C)O)c12)C(O)=O
Show InChI InChI=1S/C36H40N4O4/c1-4-32-30(36(43)44)21-37-40(32)33-10-6-9-31(38-33)29-8-5-7-25-11-14-28(34(25)29)20-26-12-13-27(19-22(26)2)24-15-17-39(18-16-24)35(42)23(3)41/h5-10,12-13,19,21,23-24,28,41H,4,11,14-18,20H2,1-3H3,(H,43,44)/t23-,28?/m0/s1
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NOVARTIS AG

US Patent


Assay Description
Chinese hamster ovary (CHO) cells overexpressing soluble guanylate cyclase were generated to test the effect of sGC activators in a cellular context....


US Patent US10550102 (2020)


BindingDB Entry DOI: 10.7270/Q2PC34SQ
More data for this
Ligand-Target Pair
Soluble Guanylate Cyclases


(Homo sapiens (Human))
BDBM430993
PNG
(US10550102, Example 63a)
Show SMILES CCc1c(cnn1-c1cccc(n1)-c1cccc2CCC(Nc3ccc(C4CCN(CC4)C(=O)C4CC4)c(CC)n3)c12)C(O)=O
Show InChI InChI=1S/C36H40N6O3/c1-3-28-25(22-17-19-41(20-18-22)35(43)24-11-12-24)14-16-32(38-28)39-30-15-13-23-7-5-8-26(34(23)30)29-9-6-10-33(40-29)42-31(4-2)27(21-37-42)36(44)45/h5-10,14,16,21-22,24,30H,3-4,11-13,15,17-20H2,1-2H3,(H,38,39)(H,44,45)
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NOVARTIS AG

US Patent


Assay Description
Chinese hamster ovary (CHO) cells overexpressing soluble guanylate cyclase were generated to test the effect of sGC activators in a cellular context....


US Patent US10550102 (2020)


BindingDB Entry DOI: 10.7270/Q2PC34SQ
More data for this
Ligand-Target Pair
Soluble Guanylate Cyclases


(Homo sapiens (Human))
BDBM430739
PNG
(US10550102, Example 3a)
Show SMILES Cc1cc(ccc1OC1CCc2cccc(c12)-c1cccc(n1)-n1ncc(C(O)=O)c1C(F)(F)F)C1CCN(CC1)C(=O)C1CC1
Show InChI InChI=1S/C35H33F3N4O4/c1-20-18-24(21-14-16-41(17-15-21)33(43)23-8-9-23)11-12-28(20)46-29-13-10-22-4-2-5-25(31(22)29)27-6-3-7-30(40-27)42-32(35(36,37)38)26(19-39-42)34(44)45/h2-7,11-12,18-19,21,23,29H,8-10,13-17H2,1H3,(H,44,45)
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n/an/an/an/a 1n/an/an/an/a



NOVARTIS AG

US Patent


Assay Description
Chinese hamster ovary (CHO) cells overexpressing soluble guanylate cyclase were generated to test the effect of sGC activators in a cellular context....


US Patent US10550102 (2020)


BindingDB Entry DOI: 10.7270/Q2PC34SQ
More data for this
Ligand-Target Pair
Soluble Guanylate Cyclases


(Homo sapiens (Human))
BDBM430859
PNG
(US10550102, Example 3b)
Show SMILES CCOC(=O)c1cnn(c1C(F)(F)F)-c1cccc(n1)-c1cccc2CCC(Oc3ccc(cc3C)C3CCN(CC3)C(=O)C3CC3)c12
Show InChI InChI=1S/C37H37F3N4O4/c1-3-47-36(46)28-21-41-44(34(28)37(38,39)40)32-9-5-8-29(42-32)27-7-4-6-24-12-15-31(33(24)27)48-30-14-13-26(20-22(30)2)23-16-18-43(19-17-23)35(45)25-10-11-25/h4-9,13-14,20-21,23,25,31H,3,10-12,15-19H2,1-2H3
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NOVARTIS AG

US Patent


Assay Description
Chinese hamster ovary (CHO) cells overexpressing soluble guanylate cyclase were generated to test the effect of sGC activators in a cellular context....


US Patent US10550102 (2020)


BindingDB Entry DOI: 10.7270/Q2PC34SQ
More data for this
Ligand-Target Pair
Soluble Guanylate Cyclases


(Homo sapiens (Human))
BDBM430860
PNG
(US10550102, Example 9. b). (-))
Show SMILES Cc1c(cnn1-c1cccc(n1)-c1cccc2CCC(Nc3ccc(cc3)C3CCN(CC3)C(=O)C3CC3)c12)C(O)=O
Show InChI InChI=1S/C34H35N5O3/c1-21-28(34(41)42)20-35-39(21)31-7-3-6-29(37-31)27-5-2-4-24-12-15-30(32(24)27)36-26-13-10-22(11-14-26)23-16-18-38(19-17-23)33(40)25-8-9-25/h2-7,10-11,13-14,20,23,25,30,36H,8-9,12,15-19H2,1H3,(H,41,42)
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n/an/an/an/a 184n/an/an/an/a



NOVARTIS AG

US Patent


Assay Description
Chinese hamster ovary (CHO) cells overexpressing soluble guanylate cyclase were generated to test the effect of sGC activators in a cellular context....


US Patent US10550102 (2020)


BindingDB Entry DOI: 10.7270/Q2PC34SQ
More data for this
Ligand-Target Pair
Soluble Guanylate Cyclases


(Homo sapiens (Human))
BDBM430861
PNG
(US10550102, Example 4a)
Show SMILES OC(=O)c1cnn(c1C(F)(F)F)-c1cccc(n1)-c1cccc2CCC(Oc3ccc4CN(Cc5ccccn5)CCc4c3)c12
Show InChI InChI=1S/C34H28F3N5O3/c35-34(36,37)32-27(33(43)44)18-39-42(32)30-9-4-8-28(40-30)26-7-3-5-21-11-13-29(31(21)26)45-25-12-10-23-19-41(16-14-22(23)17-25)20-24-6-1-2-15-38-24/h1-10,12,15,17-18,29H,11,13-14,16,19-20H2,(H,43,44)
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NOVARTIS AG

US Patent


Assay Description
Chinese hamster ovary (CHO) cells overexpressing soluble guanylate cyclase were generated to test the effect of sGC activators in a cellular context....


US Patent US10550102 (2020)


BindingDB Entry DOI: 10.7270/Q2PC34SQ
More data for this
Ligand-Target Pair
Soluble Guanylate Cyclases


(Homo sapiens (Human))
BDBM430862
PNG
(US10550102, Example 9. b). (+))
Show SMILES Cc1c(cnn1-c1cccc(n1)-c1cccc2CCC(Nc3ccc(cc3)C3CCN(CC3)C(=O)C3CC3)c12)C(O)=O
Show InChI InChI=1S/C34H35N5O3/c1-21-28(34(41)42)20-35-39(21)31-7-3-6-29(37-31)27-5-2-4-24-12-15-30(32(24)27)36-26-13-10-22(11-14-26)23-16-18-38(19-17-23)33(40)25-8-9-25/h2-7,10-11,13-14,20,23,25,30,36H,8-9,12,15-19H2,1H3,(H,41,42)
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NOVARTIS AG

US Patent


Assay Description
Chinese hamster ovary (CHO) cells overexpressing soluble guanylate cyclase were generated to test the effect of sGC activators in a cellular context....


US Patent US10550102 (2020)


BindingDB Entry DOI: 10.7270/Q2PC34SQ
More data for this
Ligand-Target Pair
Soluble Guanylate Cyclases


(Homo sapiens (Human))
BDBM430864
PNG
(US10550102, Example 10a)
Show SMILES CCc1c(cnn1-c1cccc(n1)-c1cccc2CCC(Nc3ccc(cc3C)C3CCN(CC3)C(=O)C3CC3)c12)C(O)=O
Show InChI InChI=1S/C36H39N5O3/c1-3-32-28(36(43)44)21-37-41(32)33-9-5-8-30(39-33)27-7-4-6-24-12-15-31(34(24)27)38-29-14-13-26(20-22(29)2)23-16-18-40(19-17-23)35(42)25-10-11-25/h4-9,13-14,20-21,23,25,31,38H,3,10-12,15-19H2,1-2H3,(H,43,44)
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NOVARTIS AG

US Patent


Assay Description
Chinese hamster ovary (CHO) cells overexpressing soluble guanylate cyclase were generated to test the effect of sGC activators in a cellular context....


US Patent US10550102 (2020)


BindingDB Entry DOI: 10.7270/Q2PC34SQ
More data for this
Ligand-Target Pair
Soluble Guanylate Cyclases


(Homo sapiens (Human))
BDBM430867
PNG
(US10550102, Example 5-2)
Show SMILES Cc1cc2CCC(Oc3ccc(cc3C)C3CCN(CC3)C(=O)C3CC3)c2c(c1)-c1cccc(n1)-n1ncc(C(O)=O)c1C(F)(F)F
Show InChI InChI=1S/C36H35F3N4O4/c1-20-16-25-9-11-30(47-29-10-8-24(18-21(29)2)22-12-14-42(15-13-22)34(44)23-6-7-23)32(25)26(17-20)28-4-3-5-31(41-28)43-33(36(37,38)39)27(19-40-43)35(45)46/h3-5,8,10,16-19,22-23,30H,6-7,9,11-15H2,1-2H3,(H,45,46)
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NOVARTIS AG

US Patent


Assay Description
Chinese hamster ovary (CHO) cells overexpressing soluble guanylate cyclase were generated to test the effect of sGC activators in a cellular context....


US Patent US10550102 (2020)


BindingDB Entry DOI: 10.7270/Q2PC34SQ
More data for this
Ligand-Target Pair
Soluble Guanylate Cyclases


(Homo sapiens (Human))
BDBM430873
PNG
(US10550102, Example 5-5)
Show SMILES Cc1cc(ccc1O[C@H]1CCc2cccc(c12)-c1cccc(n1)-n1cc(cn1)C(O)=O)C1CCN(CC1)C(=O)C1CC1
Show InChI InChI=1S/C34H34N4O4/c1-21-18-25(22-14-16-37(17-15-22)33(39)24-8-9-24)11-12-29(21)42-30-13-10-23-4-2-5-27(32(23)30)28-6-3-7-31(36-28)38-20-26(19-35-38)34(40)41/h2-7,11-12,18-20,22,24,30H,8-10,13-17H2,1H3,(H,40,41)/t30-/m0/s1
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NOVARTIS AG

US Patent


Assay Description
Chinese hamster ovary (CHO) cells overexpressing soluble guanylate cyclase were generated to test the effect of sGC activators in a cellular context....


US Patent US10550102 (2020)


BindingDB Entry DOI: 10.7270/Q2PC34SQ
More data for this
Ligand-Target Pair
Soluble Guanylate Cyclases


(Homo sapiens (Human))
BDBM430877
PNG
(US10550102, Example 5-7)
Show SMILES CCc1c(cnn1-c1cccc(n1)-c1cccc2CC[C@H](Oc3ccc(cc3C)C3CCN(CC3)C(=O)C3CC3)c12)C(O)=O
Show InChI InChI=1S/C36H38N4O4/c1-3-30-28(36(42)43)21-37-40(30)33-9-5-8-29(38-33)27-7-4-6-24-12-15-32(34(24)27)44-31-14-13-26(20-22(31)2)23-16-18-39(19-17-23)35(41)25-10-11-25/h4-9,13-14,20-21,23,25,32H,3,10-12,15-19H2,1-2H3,(H,42,43)/t32-/m0/s1
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NOVARTIS AG

US Patent


Assay Description
Chinese hamster ovary (CHO) cells overexpressing soluble guanylate cyclase were generated to test the effect of sGC activators in a cellular context....


US Patent US10550102 (2020)


BindingDB Entry DOI: 10.7270/Q2PC34SQ
More data for this
Ligand-Target Pair
Soluble Guanylate Cyclases


(Homo sapiens (Human))
BDBM430879
PNG
(US10550102, Example 5-8)
Show SMILES CCc1c(cnn1-c1cccc(n1)-c1cccc2CC[C@H](Oc3ccc(cc3C)C3CCN(CC(F)(F)F)CC3)c12)C(O)=O
Show InChI InChI=1S/C34H35F3N4O3/c1-3-28-26(33(42)43)19-38-41(28)31-9-5-8-27(39-31)25-7-4-6-23-10-13-30(32(23)25)44-29-12-11-24(18-21(29)2)22-14-16-40(17-15-22)20-34(35,36)37/h4-9,11-12,18-19,22,30H,3,10,13-17,20H2,1-2H3,(H,42,43)/t30-/m0/s1
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NOVARTIS AG

US Patent


Assay Description
Chinese hamster ovary (CHO) cells overexpressing soluble guanylate cyclase were generated to test the effect of sGC activators in a cellular context....


US Patent US10550102 (2020)


BindingDB Entry DOI: 10.7270/Q2PC34SQ
More data for this
Ligand-Target Pair
Soluble Guanylate Cyclases


(Homo sapiens (Human))
BDBM430901
PNG
(US10550102, Example (-)-20-1)
Show SMILES CCc1c(cnn1-c1cccc(n1)-c1cccc2C(C)CN(Cc3ccc(C4CCN(CC4)C(=O)C4CC4)c(CC)c3)c12)C(O)=O
Show InChI InChI=1S/C38H43N5O3/c1-4-26-20-25(12-15-30(26)27-16-18-41(19-17-27)37(44)28-13-14-28)23-42-22-24(3)29-8-6-9-31(36(29)42)33-10-7-11-35(40-33)43-34(5-2)32(21-39-43)38(45)46/h6-12,15,20-21,24,27-28H,4-5,13-14,16-19,22-23H2,1-3H3,(H,45,46)
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NOVARTIS AG

US Patent


Assay Description
Chinese hamster ovary (CHO) cells overexpressing soluble guanylate cyclase were generated to test the effect of sGC activators in a cellular context....


US Patent US10550102 (2020)


BindingDB Entry DOI: 10.7270/Q2PC34SQ
More data for this
Ligand-Target Pair
Soluble Guanylate Cyclases


(Homo sapiens (Human))
BDBM430910
PNG
(US10550102, Example (+)-46-6)
Show SMILES CCc1cc(NC2CCc3cccc(c23)-c2cccc(n2)-n2ncc(C(O)=O)c2C)ccc1C1CCN(CC1)C(=O)C1CC1
Show InChI InChI=1S/C36H39N5O3/c1-3-23-20-27(13-14-28(23)24-16-18-40(19-17-24)35(42)26-10-11-26)38-32-15-12-25-6-4-7-29(34(25)32)31-8-5-9-33(39-31)41-22(2)30(21-37-41)36(43)44/h4-9,13-14,20-21,24,26,32,38H,3,10-12,15-19H2,1-2H3,(H,43,44)
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NOVARTIS AG

US Patent


Assay Description
Chinese hamster ovary (CHO) cells overexpressing soluble guanylate cyclase were generated to test the effect of sGC activators in a cellular context....


US Patent US10550102 (2020)


BindingDB Entry DOI: 10.7270/Q2PC34SQ
More data for this
Ligand-Target Pair
Soluble Guanylate Cyclases


(Homo sapiens (Human))
BDBM430911
PNG
(US10550102, Example 21-1 | US10550102, Example 21-...)
Show SMILES CCc1c(cnn1-c1cccc(n1)-c1cccc2CCN(Cc3ccc(cc3C)C3CCN(CC3)C(=O)C3CC3)c12)C(O)=O
Show InChI InChI=1S/C36H39N5O3/c1-3-32-30(36(43)44)21-37-41(32)33-9-5-8-31(38-33)29-7-4-6-25-16-19-40(34(25)29)22-28-13-12-27(20-23(28)2)24-14-17-39(18-15-24)35(42)26-10-11-26/h4-9,12-13,20-21,24,26H,3,10-11,14-19,22H2,1-2H3,(H,43,44)
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NOVARTIS AG

US Patent


Assay Description
Chinese hamster ovary (CHO) cells overexpressing soluble guanylate cyclase were generated to test the effect of sGC activators in a cellular context....


US Patent US10550102 (2020)


BindingDB Entry DOI: 10.7270/Q2PC34SQ
More data for this
Ligand-Target Pair
Soluble Guanylate Cyclases


(Homo sapiens (Human))
BDBM430926
PNG
(US10550102, Example 50b)
Show SMILES CCOC(=O)c1cnn(c1CC)-c1cccc(n1)-c1cccc2CCC(Nc3ccc(C4CCN(CC4)C(=O)[C@@H](O)CC)c(CC)c3)c12
Show InChI InChI=1S/C39H47N5O4/c1-5-25-23-28(16-17-29(25)26-19-21-43(22-20-26)38(46)35(45)7-3)41-33-18-15-27-11-9-12-30(37(27)33)32-13-10-14-36(42-32)44-34(6-2)31(24-40-44)39(47)48-8-4/h9-14,16-17,23-24,26,33,35,41,45H,5-8,15,18-22H2,1-4H3/t33?,35-/m0/s1
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NOVARTIS AG

US Patent


Assay Description
Chinese hamster ovary (CHO) cells overexpressing soluble guanylate cyclase were generated to test the effect of sGC activators in a cellular context....


US Patent US10550102 (2020)


BindingDB Entry DOI: 10.7270/Q2PC34SQ
More data for this
Ligand-Target Pair
Soluble Guanylate Cyclases


(Homo sapiens (Human))
BDBM430930
PNG
(US10550102, Example 51b)
Show SMILES CCOC(=O)c1cnn(c1CC)-c1cccc(n1)-c1cccc2CCC(Nc3ccc(C4CCN(CC4)C(=O)OC(C)C)c(CC)c3)c12
Show InChI InChI=1S/C39H47N5O4/c1-6-26-23-29(16-17-30(26)27-19-21-43(22-20-27)39(46)48-25(4)5)41-34-18-15-28-11-9-12-31(37(28)34)33-13-10-14-36(42-33)44-35(7-2)32(24-40-44)38(45)47-8-3/h9-14,16-17,23-25,27,34,41H,6-8,15,18-22H2,1-5H3
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NOVARTIS AG

US Patent


Assay Description
Chinese hamster ovary (CHO) cells overexpressing soluble guanylate cyclase were generated to test the effect of sGC activators in a cellular context....


US Patent US10550102 (2020)


BindingDB Entry DOI: 10.7270/Q2PC34SQ
More data for this
Ligand-Target Pair
Soluble Guanylate Cyclases


(Homo sapiens (Human))
BDBM430932
PNG
(US10550102, Example (-)-52-1)
Show SMILES CCOC(=O)N1CCC(CC1)c1ccc(NC2CCc3cccc(c23)-c2cccc(n2)-n2ncc(C(O)=O)c2CC)cc1CC
Show InChI InChI=1S/C36H41N5O4/c1-4-23-21-26(14-15-27(23)24-17-19-40(20-18-24)36(44)45-6-3)38-31-16-13-25-9-7-10-28(34(25)31)30-11-8-12-33(39-30)41-32(5-2)29(22-37-41)35(42)43/h7-12,14-15,21-22,24,31,38H,4-6,13,16-20H2,1-3H3,(H,42,43)
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NOVARTIS AG

US Patent


Assay Description
Chinese hamster ovary (CHO) cells overexpressing soluble guanylate cyclase were generated to test the effect of sGC activators in a cellular context....


US Patent US10550102 (2020)


BindingDB Entry DOI: 10.7270/Q2PC34SQ
More data for this
Ligand-Target Pair
Soluble Guanylate Cyclases


(Homo sapiens (Human))
BDBM430936
PNG
(US10550102, Example (-)-52-2)
Show SMILES CCc1c(cnn1-c1cccc(n1)-c1cccc2CCC(Nc3ccc(C4CCN(CC4)C(=O)OC)c(CC)c3)c12)C(O)=O
Show InChI InChI=1S/C35H39N5O4/c1-4-22-20-25(13-14-26(22)23-16-18-39(19-17-23)35(43)44-3)37-30-15-12-24-8-6-9-27(33(24)30)29-10-7-11-32(38-29)40-31(5-2)28(21-36-40)34(41)42/h6-11,13-14,20-21,23,30,37H,4-5,12,15-19H2,1-3H3,(H,41,42)
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NOVARTIS AG

US Patent


Assay Description
Chinese hamster ovary (CHO) cells overexpressing soluble guanylate cyclase were generated to test the effect of sGC activators in a cellular context....


US Patent US10550102 (2020)


BindingDB Entry DOI: 10.7270/Q2PC34SQ
More data for this
Ligand-Target Pair
Soluble Guanylate Cyclases


(Homo sapiens (Human))
BDBM430943
PNG
(US10550102, Example 32a)
Show SMILES CCc1c(cnn1-c1cccc(n1)-c1cccc2CC[C@H](Oc3ccc(C4CCN(CC4)C(=O)C(C)CCO)c(CC)c3)c12)C(O)=O
Show InChI InChI=1S/C38H44N4O5/c1-4-25-22-28(13-14-29(25)26-16-19-41(20-17-26)37(44)24(3)18-21-43)47-34-15-12-27-8-6-9-30(36(27)34)32-10-7-11-35(40-32)42-33(5-2)31(23-39-42)38(45)46/h6-11,13-14,22-24,26,34,43H,4-5,12,15-21H2,1-3H3,(H,45,46)/t24?,34-/m0/s1
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NOVARTIS AG

US Patent


Assay Description
Chinese hamster ovary (CHO) cells overexpressing soluble guanylate cyclase were generated to test the effect of sGC activators in a cellular context....


US Patent US10550102 (2020)


BindingDB Entry DOI: 10.7270/Q2PC34SQ
More data for this
Ligand-Target Pair
Soluble Guanylate Cyclases


(Homo sapiens (Human))
BDBM430944
PNG
(US10550102, Example 52-4)
Show SMILES CCOC(=O)N1CCC(CC1)c1ccc(NC2CCc3cccc(c23)-c2cccc(n2)-n2ncc(C(O)=O)c2C)c(C)c1
Show InChI InChI=1S/C34H37N5O4/c1-4-43-34(42)38-17-15-23(16-18-38)25-12-13-28(21(2)19-25)36-30-14-11-24-7-5-8-26(32(24)30)29-9-6-10-31(37-29)39-22(3)27(20-35-39)33(40)41/h5-10,12-13,19-20,23,30,36H,4,11,14-18H2,1-3H3,(H,40,41)
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NOVARTIS AG

US Patent


Assay Description
Chinese hamster ovary (CHO) cells overexpressing soluble guanylate cyclase were generated to test the effect of sGC activators in a cellular context....


US Patent US10550102 (2020)


BindingDB Entry DOI: 10.7270/Q2PC34SQ
More data for this
Ligand-Target Pair
Soluble Guanylate Cyclases


(Homo sapiens (Human))
BDBM430948
PNG
(US10550102, Example 52-6)
Show SMILES CC(=C)OC(=O)N1CCC(CC1)c1ccc(NC2CCc3cccc(c23)-c2cccc(n2)-n2ncc(C(O)=O)c2C)c(C)c1
Show InChI InChI=1S/C35H37N5O4/c1-21(2)44-35(43)39-17-15-24(16-18-39)26-12-13-29(22(3)19-26)37-31-14-11-25-7-5-8-27(33(25)31)30-9-6-10-32(38-30)40-23(4)28(20-36-40)34(41)42/h5-10,12-13,19-20,24,31,37H,1,11,14-18H2,2-4H3,(H,41,42)
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NOVARTIS AG

US Patent


Assay Description
Chinese hamster ovary (CHO) cells overexpressing soluble guanylate cyclase were generated to test the effect of sGC activators in a cellular context....


US Patent US10550102 (2020)


BindingDB Entry DOI: 10.7270/Q2PC34SQ
More data for this
Ligand-Target Pair
Soluble Guanylate Cyclases


(Homo sapiens (Human))
BDBM430953
PNG
(US10550102, Example 35a)
Show SMILES C[C@H](O)C(=O)N1CCC(CC1)c1ccc(NC2COc3cccc(c23)-c2cccc(n2)-n2ncc(C(O)=O)c2C)c(C)c1
Show InChI InChI=1S/C33H35N5O5/c1-19-16-23(22-12-14-37(15-13-22)32(40)21(3)39)10-11-26(19)35-28-18-43-29-8-4-6-24(31(28)29)27-7-5-9-30(36-27)38-20(2)25(17-34-38)33(41)42/h4-11,16-17,21-22,28,35,39H,12-15,18H2,1-3H3,(H,41,42)/t21-,28?/m0/s1
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NOVARTIS AG

US Patent


Assay Description
Chinese hamster ovary (CHO) cells overexpressing soluble guanylate cyclase were generated to test the effect of sGC activators in a cellular context....


US Patent US10550102 (2020)


BindingDB Entry DOI: 10.7270/Q2PC34SQ
More data for this
Ligand-Target Pair
Soluble Guanylate Cyclases


(Homo sapiens (Human))
BDBM430959
PNG
(US10550102, Example (-)-53-3)
Show SMILES Cc1c(cnn1-c1cccc(n1)-c1cccc2CCC(Nc3c(C)cc(cc3F)C3CCN(CC3)C(=O)CC3CC3)c12)C(O)=O
Show InChI InChI=1S/C36H38FN5O3/c1-21-17-26(24-13-15-41(16-14-24)33(43)18-23-9-10-23)19-29(37)35(21)40-31-12-11-25-5-3-6-27(34(25)31)30-7-4-8-32(39-30)42-22(2)28(20-38-42)36(44)45/h3-8,17,19-20,23-24,31,40H,9-16,18H2,1-2H3,(H,44,45)
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NOVARTIS AG

US Patent


Assay Description
Chinese hamster ovary (CHO) cells overexpressing soluble guanylate cyclase were generated to test the effect of sGC activators in a cellular context....


US Patent US10550102 (2020)


BindingDB Entry DOI: 10.7270/Q2PC34SQ
More data for this
Ligand-Target Pair
Soluble Guanylate Cyclases


(Homo sapiens (Human))
BDBM430985
PNG
(Example 60-A. (+-)-Ethyl 1-(6-(3-((4-(1-cyclopropy...)
Show SMILES Cc1c(cnn1-c1cccc(n1)-c1cccc2CCC(Nc3ccc(cc3C)C3CCN(CC3)C3CC3)c12)C(O)=O
Show InChI InChI=1S/C34H37N5O2/c1-21-19-25(23-15-17-38(18-16-23)26-11-12-26)10-13-29(21)36-31-14-9-24-5-3-6-27(33(24)31)30-7-4-8-32(37-30)39-22(2)28(20-35-39)34(40)41/h3-8,10,13,19-20,23,26,31,36H,9,11-12,14-18H2,1-2H3,(H,40,41)
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NOVARTIS AG

US Patent


Assay Description
Chinese hamster ovary (CHO) cells overexpressing soluble guanylate cyclase were generated to test the effect of sGC activators in a cellular context....


US Patent US10550102 (2020)


BindingDB Entry DOI: 10.7270/Q2PC34SQ
More data for this
Ligand-Target Pair
Soluble Guanylate Cyclases


(Homo sapiens (Human))
BDBM430998
PNG
(US10550102, Example 41. b). (+))
Show SMILES CCc1c(cnn1-c1cccc(n1)-c1cccc2CCC(Cc3ccc(C4CCN(CC4)C(=O)OC)c(CC)c3)c12)C(O)=O
Show InChI InChI=1S/C36H40N4O4/c1-4-24-20-23(12-15-28(24)25-16-18-39(19-17-25)36(43)44-3)21-27-14-13-26-8-6-9-29(34(26)27)31-10-7-11-33(38-31)40-32(5-2)30(22-37-40)35(41)42/h6-12,15,20,22,25,27H,4-5,13-14,16-19,21H2,1-3H3,(H,41,42)
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NOVARTIS AG

US Patent


Assay Description
Chinese hamster ovary (CHO) cells overexpressing soluble guanylate cyclase were generated to test the effect of sGC activators in a cellular context....


US Patent US10550102 (2020)


BindingDB Entry DOI: 10.7270/Q2PC34SQ
More data for this
Ligand-Target Pair
Soluble Guanylate Cyclases


(Homo sapiens (Human))
BDBM431007
PNG
(US10550102, Example 64-6)
Show SMILES CCc1c(cnn1-c1cccc(n1)-c1cccc2CC[C@H](Oc3ccc(C4CCN(CC4)C(=O)OCC4CC4)c(CC)c3)c12)C(O)=O
Show InChI InChI=1S/C38H42N4O5/c1-3-25-21-28(14-15-29(25)26-17-19-41(20-18-26)38(45)46-23-24-11-12-24)47-34-16-13-27-7-5-8-30(36(27)34)32-9-6-10-35(40-32)42-33(4-2)31(22-39-42)37(43)44/h5-10,14-15,21-22,24,26,34H,3-4,11-13,16-20,23H2,1-2H3,(H,43,44)/t34-/m0/s1
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NOVARTIS AG

US Patent


Assay Description
Chinese hamster ovary (CHO) cells overexpressing soluble guanylate cyclase were generated to test the effect of sGC activators in a cellular context....


US Patent US10550102 (2020)


BindingDB Entry DOI: 10.7270/Q2PC34SQ
More data for this
Ligand-Target Pair
Soluble Guanylate Cyclases


(Homo sapiens (Human))
BDBM431009
PNG
(US10550102, Example 64-7)
Show SMILES CCc1c(cnn1-c1cccc(n1)-c1cccc2CC[C@H](Oc3ccc(C4CCN(CC4)C(=O)OC)c(CC)c3)c12)C(O)=O
Show InChI InChI=1S/C35H38N4O5/c1-4-22-20-25(13-14-26(22)23-16-18-38(19-17-23)35(42)43-3)44-31-15-12-24-8-6-9-27(33(24)31)29-10-7-11-32(37-29)39-30(5-2)28(21-36-39)34(40)41/h6-11,13-14,20-21,23,31H,4-5,12,15-19H2,1-3H3,(H,40,41)/t31-/m0/s1
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NOVARTIS AG

US Patent


Assay Description
Chinese hamster ovary (CHO) cells overexpressing soluble guanylate cyclase were generated to test the effect of sGC activators in a cellular context....


US Patent US10550102 (2020)


BindingDB Entry DOI: 10.7270/Q2PC34SQ
More data for this
Ligand-Target Pair
Soluble Guanylate Cyclases


(Homo sapiens (Human))
BDBM430649
PNG
(US10550102, Example (+)-1. b))
Show SMILES Cc1cc(ccc1OC1CCc2cccc(c12)-c1cccc(c1)-n1ncc(C(O)=O)c1C(F)(F)F)C1CCN(CC1)C(=O)C1CC1
Show InChI InChI=1S/C36H34F3N3O4/c1-21-18-25(22-14-16-41(17-15-22)34(43)24-8-9-24)11-12-30(21)46-31-13-10-23-4-3-7-28(32(23)31)26-5-2-6-27(19-26)42-33(36(37,38)39)29(20-40-42)35(44)45/h2-7,11-12,18-20,22,24,31H,8-10,13-17H2,1H3,(H,44,45)
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NOVARTIS AG

US Patent


Assay Description
Chinese hamster ovary (CHO) cells overexpressing soluble guanylate cyclase were generated to test the effect of sGC activators in a cellular context....


US Patent US10550102 (2020)


BindingDB Entry DOI: 10.7270/Q2PC34SQ
More data for this
Ligand-Target Pair
Soluble Guanylate Cyclases


(Homo sapiens (Human))
BDBM430869
PNG
(US10550102, Example 5-3)
Show SMILES CCc1cc(O[C@H]2CCc3cccc(c23)-c2cccc(n2)-n2ncc(C(O)=O)c2C(F)(F)F)ccc1C1CCN(CC1)C(=O)C1CC1
Show InChI InChI=1S/C36H35F3N4O4/c1-2-21-19-25(12-13-26(21)22-15-17-42(18-16-22)34(44)24-9-10-24)47-30-14-11-23-5-3-6-27(32(23)30)29-7-4-8-31(41-29)43-33(36(37,38)39)28(20-40-43)35(45)46/h3-8,12-13,19-20,22,24,30H,2,9-11,14-18H2,1H3,(H,45,46)/t30-/m0/s1
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NOVARTIS AG

US Patent


Assay Description
Chinese hamster ovary (CHO) cells overexpressing soluble guanylate cyclase were generated to test the effect of sGC activators in a cellular context....


US Patent US10550102 (2020)


BindingDB Entry DOI: 10.7270/Q2PC34SQ
More data for this
Ligand-Target Pair
Soluble Guanylate Cyclases


(Homo sapiens (Human))
BDBM430878
PNG
(Example 13-A. tert-Butyl 4-(4-((7-(6-(4-(ethoxycar...)
Show SMILES CCOC(=O)c1cnn(c1C(F)(F)F)-c1cccc(n1)-c1cccc2CCN(Cc3ccc(C4CCN(CC4)C(=O)OC(C)(C)C)c(CC)c3)c12
Show InChI InChI=1S/C39H44F3N5O4/c1-6-26-22-25(14-15-29(26)27-16-19-45(20-17-27)37(49)51-38(3,4)5)24-46-21-18-28-10-8-11-30(34(28)46)32-12-9-13-33(44-32)47-35(39(40,41)42)31(23-43-47)36(48)50-7-2/h8-15,22-23,27H,6-7,16-21,24H2,1-5H3
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NOVARTIS AG

US Patent


Assay Description
Chinese hamster ovary (CHO) cells overexpressing soluble guanylate cyclase were generated to test the effect of sGC activators in a cellular context....


US Patent US10550102 (2020)


BindingDB Entry DOI: 10.7270/Q2PC34SQ
More data for this
Ligand-Target Pair
Soluble Guanylate Cyclases


(Homo sapiens (Human))
BDBM430884
PNG
(Example 16-A. Ethyl 5-ethyl-1-(6-(1-(3-ethyl-4-(2,...)
Show SMILES CCOC(=O)c1cnn(c1CC)-c1cccc(n1)-c1cccc2CCN(Cc3ccc(C4CCN(CC(F)(F)F)CC4)c(CC)c3)c12
Show InChI InChI=1S/C37H42F3N5O2/c1-4-26-21-25(13-14-29(26)27-15-18-43(19-16-27)24-37(38,39)40)23-44-20-17-28-9-7-10-30(35(28)44)32-11-8-12-34(42-32)45-33(5-2)31(22-41-45)36(46)47-6-3/h7-14,21-22,27H,4-6,15-20,23-24H2,1-3H3
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NOVARTIS AG

US Patent


Assay Description
Chinese hamster ovary (CHO) cells overexpressing soluble guanylate cyclase were generated to test the effect of sGC activators in a cellular context....


US Patent US10550102 (2020)


BindingDB Entry DOI: 10.7270/Q2PC34SQ
More data for this
Ligand-Target Pair
Soluble Guanylate Cyclases


(Homo sapiens (Human))
BDBM430885
PNG
(US10550102, Example 6. b). (-))
Show SMILES Cc1cc(ccc1NC1CCc2cccc(c12)-c1cccc(c1)-n1ncc(C(O)=O)c1C(F)(F)F)C1CCN(CC1)C(=O)C1CC1
Show InChI InChI=1S/C36H35F3N4O3/c1-21-18-25(22-14-16-42(17-15-22)34(44)24-8-9-24)11-12-30(21)41-31-13-10-23-4-3-7-28(32(23)31)26-5-2-6-27(19-26)43-33(36(37,38)39)29(20-40-43)35(45)46/h2-7,11-12,18-20,22,24,31,41H,8-10,13-17H2,1H3,(H,45,46)
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NOVARTIS AG

US Patent


Assay Description
Chinese hamster ovary (CHO) cells overexpressing soluble guanylate cyclase were generated to test the effect of sGC activators in a cellular context....


US Patent US10550102 (2020)


BindingDB Entry DOI: 10.7270/Q2PC34SQ
More data for this
Ligand-Target Pair
Soluble Guanylate Cyclases


(Homo sapiens (Human))
BDBM430886
PNG
(US10550102, Example 45a)
Show SMILES Cc1c(cnn1-c1cccc(n1)-c1cccc2CCC(Nc3ccc(cc3C)C3CCN(CC3)C(=O)C3CCC3)c12)C(O)=O
Show InChI InChI=1S/C36H39N5O3/c1-22-20-27(24-16-18-40(19-17-24)35(42)26-7-3-8-26)13-14-30(22)38-32-15-12-25-6-4-9-28(34(25)32)31-10-5-11-33(39-31)41-23(2)29(21-37-41)36(43)44/h4-6,9-11,13-14,20-21,24,26,32,38H,3,7-8,12,15-19H2,1-2H3,(H,43,44)
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NOVARTIS AG

US Patent


Assay Description
Chinese hamster ovary (CHO) cells overexpressing soluble guanylate cyclase were generated to test the effect of sGC activators in a cellular context....


US Patent US10550102 (2020)


BindingDB Entry DOI: 10.7270/Q2PC34SQ
More data for this
Ligand-Target Pair
Soluble Guanylate Cyclases


(Homo sapiens (Human))
BDBM430895
PNG
(US10550102, Example 19a)
Show SMILES CCc1cc(CN2CC(C)c3cccc(c23)-c2cccc(n2)-n2ncc(C(O)=O)c2C(F)(F)F)ccc1C1CCN(CC1)C(=O)C1CC1
Show InChI InChI=1S/C37H38F3N5O3/c1-3-24-18-23(10-13-28(24)25-14-16-43(17-15-25)35(46)26-11-12-26)21-44-20-22(2)27-6-4-7-29(33(27)44)31-8-5-9-32(42-31)45-34(37(38,39)40)30(19-41-45)36(47)48/h4-10,13,18-19,22,25-26H,3,11-12,14-17,20-21H2,1-2H3,(H,47,48)
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NOVARTIS AG

US Patent


Assay Description
Chinese hamster ovary (CHO) cells overexpressing soluble guanylate cyclase were generated to test the effect of sGC activators in a cellular context....


US Patent US10550102 (2020)


BindingDB Entry DOI: 10.7270/Q2PC34SQ
More data for this
Ligand-Target Pair
Soluble Guanylate Cyclases


(Homo sapiens (Human))
BDBM430902
PNG
(US10550102, Example (+) or (-)-46-4)
Show SMILES Cc1c(cnn1-c1cccc(n1)-c1cccc2CCC(Nc3ccc(C4CCN(CC4)C(=O)CC4CC4)c(F)c3C)c12)C(O)=O
Show InChI InChI=1S/C36H38FN5O3/c1-21-29(14-12-26(35(21)37)24-15-17-41(18-16-24)33(43)19-23-9-10-23)39-31-13-11-25-5-3-6-27(34(25)31)30-7-4-8-32(40-30)42-22(2)28(20-38-42)36(44)45/h3-8,12,14,20,23-24,31,39H,9-11,13,15-19H2,1-2H3,(H,44,45)
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NOVARTIS AG

US Patent


Assay Description
Chinese hamster ovary (CHO) cells overexpressing soluble guanylate cyclase were generated to test the effect of sGC activators in a cellular context....


US Patent US10550102 (2020)


BindingDB Entry DOI: 10.7270/Q2PC34SQ
More data for this
Ligand-Target Pair
Soluble Guanylate Cyclases


(Homo sapiens (Human))
BDBM430919
PNG
(Example 23-A. (4-(4-((7-Bromo-3,3-dimethylindolin-...)
Show SMILES CCc1c(cnn1-c1cccc(n1)-c1cccc2c1N(Cc1ccc(C3CCN(CC3)C(=O)C3CC3)c(CC)c1)CC2(C)C)C(O)=O
Show InChI InChI=1S/C39H45N5O3/c1-5-26-21-25(13-16-29(26)27-17-19-42(20-18-27)37(45)28-14-15-28)23-43-24-39(3,4)32-10-7-9-30(36(32)43)33-11-8-12-35(41-33)44-34(6-2)31(22-40-44)38(46)47/h7-13,16,21-22,27-28H,5-6,14-15,17-20,23-24H2,1-4H3,(H,46,47)
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NOVARTIS AG

US Patent


Assay Description
Chinese hamster ovary (CHO) cells overexpressing soluble guanylate cyclase were generated to test the effect of sGC activators in a cellular context....


US Patent US10550102 (2020)


BindingDB Entry DOI: 10.7270/Q2PC34SQ
More data for this
Ligand-Target Pair
Soluble Guanylate Cyclases


(Homo sapiens (Human))
BDBM430924
PNG
(US10550102, Example 50a)
Show SMILES CC[C@H](O)C(=O)N1CCC(CC1)c1ccc(NC2CCc3cccc(c23)-c2cccc(n2)-n2ncc(C(O)=O)c2CC)cc1CC
Show InChI InChI=1S/C37H43N5O4/c1-4-23-21-26(14-15-27(23)24-17-19-41(20-18-24)36(44)33(43)6-3)39-31-16-13-25-9-7-10-28(35(25)31)30-11-8-12-34(40-30)42-32(5-2)29(22-38-42)37(45)46/h7-12,14-15,21-22,24,31,33,39,43H,4-6,13,16-20H2,1-3H3,(H,45,46)/t31?,33-/m0/s1
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NOVARTIS AG

US Patent


Assay Description
Chinese hamster ovary (CHO) cells overexpressing soluble guanylate cyclase were generated to test the effect of sGC activators in a cellular context....


US Patent US10550102 (2020)


BindingDB Entry DOI: 10.7270/Q2PC34SQ
More data for this
Ligand-Target Pair
Soluble Guanylate Cyclases


(Homo sapiens (Human))
BDBM430945
PNG
(US10550102, Example 32b)
Show SMILES CCc1c(cnn1-c1cccc(n1)-c1cccc2CC[C@@H](Oc3ccc(C4CCN(CC4)C(=O)C(C)CCO)c(CC)c3)c12)C(O)=O
Show InChI InChI=1S/C38H44N4O5/c1-4-25-22-28(13-14-29(25)26-16-19-41(20-17-26)37(44)24(3)18-21-43)47-34-15-12-27-8-6-9-30(36(27)34)32-10-7-11-35(40-32)42-33(5-2)31(23-39-42)38(45)46/h6-11,13-14,22-24,26,34,43H,4-5,12,15-21H2,1-3H3,(H,45,46)/t24?,34-/m1/s1
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NOVARTIS AG

US Patent


Assay Description
Chinese hamster ovary (CHO) cells overexpressing soluble guanylate cyclase were generated to test the effect of sGC activators in a cellular context....


US Patent US10550102 (2020)


BindingDB Entry DOI: 10.7270/Q2PC34SQ
More data for this
Ligand-Target Pair
Soluble Guanylate Cyclases


(Homo sapiens (Human))
BDBM430961
PNG
(US10550102, Example (+)-53-4)
Show SMILES Cc1cc(ccc1NC1CCc2cccc(c12)-c1cccc(n1)-n1ncc(C(O)=O)c1C(F)F)C1CCN(CC1)C(=O)C1CC1
Show InChI InChI=1S/C35H35F2N5O3/c1-20-18-24(21-14-16-41(17-15-21)34(43)23-8-9-23)11-12-27(20)39-29-13-10-22-4-2-5-25(31(22)29)28-6-3-7-30(40-28)42-32(33(36)37)26(19-38-42)35(44)45/h2-7,11-12,18-19,21,23,29,33,39H,8-10,13-17H2,1H3,(H,44,45)
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NOVARTIS AG

US Patent


Assay Description
Chinese hamster ovary (CHO) cells overexpressing soluble guanylate cyclase were generated to test the effect of sGC activators in a cellular context....


US Patent US10550102 (2020)


BindingDB Entry DOI: 10.7270/Q2PC34SQ
More data for this
Ligand-Target Pair
Soluble Guanylate Cyclases


(Homo sapiens (Human))
BDBM430964
PNG
(US10550102, Example 37. b). (+))
Show SMILES Cc1c(cnn1-c1cccc(n1)-c1cccc2CCC(Cc3ccc(cc3C)C3CCN(CC3)C(=O)C3CC3)c12)C(O)=O
Show InChI InChI=1S/C36H38N4O3/c1-22-19-28(24-15-17-39(18-16-24)35(41)26-10-11-26)13-12-27(22)20-29-14-9-25-5-3-6-30(34(25)29)32-7-4-8-33(38-32)40-23(2)31(21-37-40)36(42)43/h3-8,12-13,19,21,24,26,29H,9-11,14-18,20H2,1-2H3,(H,42,43)
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NOVARTIS AG

US Patent


Assay Description
Chinese hamster ovary (CHO) cells overexpressing soluble guanylate cyclase were generated to test the effect of sGC activators in a cellular context....


US Patent US10550102 (2020)


BindingDB Entry DOI: 10.7270/Q2PC34SQ
More data for this
Ligand-Target Pair
Soluble Guanylate Cyclases


(Homo sapiens (Human))
BDBM430965
PNG
(US10550102, Example 54. b). (-))
Show SMILES CCOC(=O)c1cnn(c1C)-c1cccc(c1)-c1cccc2CCC(Cc3ccc(cc3C)C3CCN(CC3)C(=O)C3CC3)c12
Show InChI InChI=1S/C39H43N3O3/c1-4-45-39(44)36-24-40-42(26(36)3)34-9-5-8-32(23-34)35-10-6-7-28-11-16-33(37(28)35)22-30-14-15-31(21-25(30)2)27-17-19-41(20-18-27)38(43)29-12-13-29/h5-10,14-15,21,23-24,27,29,33H,4,11-13,16-20,22H2,1-3H3
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NOVARTIS AG

US Patent


Assay Description
Chinese hamster ovary (CHO) cells overexpressing soluble guanylate cyclase were generated to test the effect of sGC activators in a cellular context....


US Patent US10550102 (2020)


BindingDB Entry DOI: 10.7270/Q2PC34SQ
More data for this
Ligand-Target Pair
Soluble Guanylate Cyclases


(Homo sapiens (Human))
BDBM430967
PNG
(US10550102, Example 54. b). (+))
Show SMILES CCOC(=O)c1cnn(c1C)-c1cccc(c1)-c1cccc2CCC(Cc3ccc(cc3C)C3CCN(CC3)C(=O)C3CC3)c12
Show InChI InChI=1S/C39H43N3O3/c1-4-45-39(44)36-24-40-42(26(36)3)34-9-5-8-32(23-34)35-10-6-7-28-11-16-33(37(28)35)22-30-14-15-31(21-25(30)2)27-17-19-41(20-18-27)38(43)29-12-13-29/h5-10,14-15,21,23-24,27,29,33H,4,11-13,16-20,22H2,1-3H3
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NOVARTIS AG

US Patent


Assay Description
Chinese hamster ovary (CHO) cells overexpressing soluble guanylate cyclase were generated to test the effect of sGC activators in a cellular context....


US Patent US10550102 (2020)


BindingDB Entry DOI: 10.7270/Q2PC34SQ
More data for this
Ligand-Target Pair
Soluble Guanylate Cyclases


(Homo sapiens (Human))
BDBM430970
PNG
(US10550102, Example 38-1 (+))
Show SMILES CCc1c(cnn1-c1cccc(n1)-c1cccc2CCC(Cc3ccc(C4CCN(CC4)C(=O)C4CC4)c(CC)c3)c12)C(O)=O
Show InChI InChI=1S/C38H42N4O3/c1-3-25-21-24(11-16-30(25)26-17-19-41(20-18-26)37(43)28-13-14-28)22-29-15-12-27-7-5-8-31(36(27)29)33-9-6-10-35(40-33)42-34(4-2)32(23-39-42)38(44)45/h5-11,16,21,23,26,28-29H,3-4,12-15,17-20,22H2,1-2H3,(H,44,45)
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NOVARTIS AG

US Patent


Assay Description
Chinese hamster ovary (CHO) cells overexpressing soluble guanylate cyclase were generated to test the effect of sGC activators in a cellular context....


US Patent US10550102 (2020)


BindingDB Entry DOI: 10.7270/Q2PC34SQ
More data for this
Ligand-Target Pair
Soluble Guanylate Cyclases


(Homo sapiens (Human))
BDBM430973
PNG
(US10550102, Example 55-2)
Show SMILES Cc1cc(ccc1NC1CCc2cccc(c12)-c1cccc(c1)-n1ncc(C(O)=O)c1C(F)F)C1CCN(CC1)C(=O)C1CC1
Show InChI InChI=1S/C36H36F2N4O3/c1-21-18-25(22-14-16-41(17-15-22)35(43)24-8-9-24)11-12-30(21)40-31-13-10-23-4-3-7-28(32(23)31)26-5-2-6-27(19-26)42-33(34(37)38)29(20-39-42)36(44)45/h2-7,11-12,18-20,22,24,31,34,40H,8-10,13-17H2,1H3,(H,44,45)
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NOVARTIS AG

US Patent


Assay Description
Chinese hamster ovary (CHO) cells overexpressing soluble guanylate cyclase were generated to test the effect of sGC activators in a cellular context....


US Patent US10550102 (2020)


BindingDB Entry DOI: 10.7270/Q2PC34SQ
More data for this
Ligand-Target Pair
Soluble Guanylate Cyclases


(Homo sapiens (Human))
BDBM431000
PNG
(US10550102, Example 42. b). (-))
Show SMILES CCc1c(cnn1-c1cccc(n1)-c1cccc2CCC(Cc3ccc(cc3C)C3CCN(CC3)C(=O)OC)c12)C(O)=O
Show InChI InChI=1S/C35H38N4O4/c1-4-31-29(34(40)41)21-36-39(31)32-10-6-9-30(37-32)28-8-5-7-24-11-14-27(33(24)28)20-25-12-13-26(19-22(25)2)23-15-17-38(18-16-23)35(42)43-3/h5-10,12-13,19,21,23,27H,4,11,14-18,20H2,1-3H3,(H,40,41)
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NOVARTIS AG

US Patent


Assay Description
Chinese hamster ovary (CHO) cells overexpressing soluble guanylate cyclase were generated to test the effect of sGC activators in a cellular context....


US Patent US10550102 (2020)


BindingDB Entry DOI: 10.7270/Q2PC34SQ
More data for this
Ligand-Target Pair
Soluble Guanylate Cyclases


(Homo sapiens (Human))
BDBM430863
PNG
(US10550102, Example 4b)
Show SMILES CCOC(=O)c1cnn(c1C(F)(F)F)-c1cccc(n1)-c1cccc2CCC(Oc3ccc4CN(Cc5ccccn5)CCc4c3)c12
Show InChI InChI=1S/C36H32F3N5O3/c1-2-46-35(45)29-20-41-44(34(29)36(37,38)39)32-11-6-10-30(42-32)28-9-5-7-23-13-15-31(33(23)28)47-27-14-12-25-21-43(18-16-24(25)19-27)22-26-8-3-4-17-40-26/h3-12,14,17,19-20,31H,2,13,15-16,18,21-22H2,1H3
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NOVARTIS AG

US Patent


Assay Description
Chinese hamster ovary (CHO) cells overexpressing soluble guanylate cyclase were generated to test the effect of sGC activators in a cellular context....


US Patent US10550102 (2020)


BindingDB Entry DOI: 10.7270/Q2PC34SQ
More data for this
Ligand-Target Pair
Soluble Guanylate Cyclases


(Homo sapiens (Human))
BDBM430887
PNG
(US10550102, Example 5-10)
Show SMILES CCc1cc(O[C@H]2CCc3cccc(c23)-c2cccc(n2)-n2ccc(C(O)=O)c2C)ccc1C1CCN(CC1)C(=O)C1CC1
Show InChI InChI=1S/C37H39N3O4/c1-3-24-22-28(13-14-30(24)25-16-19-39(20-17-25)36(41)27-10-11-27)44-33-15-12-26-6-4-7-31(35(26)33)32-8-5-9-34(38-32)40-21-18-29(23(40)2)37(42)43/h4-9,13-14,18,21-22,25,27,33H,3,10-12,15-17,19-20H2,1-2H3,(H,42,43)/t33-/m0/s1
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NOVARTIS AG

US Patent


Assay Description
Chinese hamster ovary (CHO) cells overexpressing soluble guanylate cyclase were generated to test the effect of sGC activators in a cellular context....


US Patent US10550102 (2020)


BindingDB Entry DOI: 10.7270/Q2PC34SQ
More data for this
Ligand-Target Pair
Soluble Guanylate Cyclases


(Homo sapiens (Human))
BDBM430889
PNG
(US10550102, Example 17a)
Show SMILES CCc1c(cnn1-c1cccc(n1)-c1cccc2C(C)CN(Cc3ccc(C4CCN(CC4)C(=O)[C@H](C)O)c(CC)c3)c12)C(O)=O
Show InChI InChI=1S/C37H43N5O4/c1-5-26-19-25(13-14-29(26)27-15-17-40(18-16-27)36(44)24(4)43)22-41-21-23(3)28-9-7-10-30(35(28)41)32-11-8-12-34(39-32)42-33(6-2)31(20-38-42)37(45)46/h7-14,19-20,23-24,27,43H,5-6,15-18,21-22H2,1-4H3,(H,45,46)/t23?,24-/m0/s1
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NOVARTIS AG

US Patent


Assay Description
Chinese hamster ovary (CHO) cells overexpressing soluble guanylate cyclase were generated to test the effect of sGC activators in a cellular context....


US Patent US10550102 (2020)


BindingDB Entry DOI: 10.7270/Q2PC34SQ
More data for this
Ligand-Target Pair
Soluble Guanylate Cyclases


(Homo sapiens (Human))
BDBM430897
PNG
(US10550102, Example 19b)
Show SMILES CCOC(=O)c1cnn(c1C(F)(F)F)-c1cccc(n1)-c1cccc2c(C)c[nH]c12
Show InChI InChI=1S/C21H17F3N4O2/c1-3-30-20(29)15-11-26-28(19(15)21(22,23)24)17-9-5-8-16(27-17)14-7-4-6-13-12(2)10-25-18(13)14/h4-11,25H,3H2,1-2H3
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NOVARTIS AG

US Patent


Assay Description
Chinese hamster ovary (CHO) cells overexpressing soluble guanylate cyclase were generated to test the effect of sGC activators in a cellular context....


US Patent US10550102 (2020)


BindingDB Entry DOI: 10.7270/Q2PC34SQ
More data for this
Ligand-Target Pair
Soluble Guanylate Cyclases


(Homo sapiens (Human))
BDBM430905
PNG
(US10550102, Example (-)-20-2)
Show SMILES CCc1c(cnn1-c1cccc(n1)-c1cccc2C(C)CN(Cc3ccc(cc3C)C3CCN(CC3)C(=O)C3CC3)c12)C(O)=O
Show InChI InChI=1S/C37H41N5O3/c1-4-33-31(37(44)45)20-38-42(33)34-10-6-9-32(39-34)30-8-5-7-29-24(3)21-41(35(29)30)22-28-14-13-27(19-23(28)2)25-15-17-40(18-16-25)36(43)26-11-12-26/h5-10,13-14,19-20,24-26H,4,11-12,15-18,21-22H2,1-3H3,(H,44,45)
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NOVARTIS AG

US Patent


Assay Description
Chinese hamster ovary (CHO) cells overexpressing soluble guanylate cyclase were generated to test the effect of sGC activators in a cellular context....


US Patent US10550102 (2020)


BindingDB Entry DOI: 10.7270/Q2PC34SQ
More data for this
Ligand-Target Pair
Soluble Guanylate Cyclases


(Homo sapiens (Human))
BDBM430939
PNG
(US10550102, Example 31-3)
Show SMILES CCc1c(cnn1-c1cccc(n1)-c1cccc2CC[C@H](Oc3ccc(C4CCN(CC4)C(=O)[C@@H](C)CO)c(CC)c3)c12)C(O)=O
Show InChI InChI=1S/C37H42N4O5/c1-4-24-20-27(13-14-28(24)25-16-18-40(19-17-25)36(43)23(3)22-42)46-33-15-12-26-8-6-9-29(35(26)33)31-10-7-11-34(39-31)41-32(5-2)30(21-38-41)37(44)45/h6-11,13-14,20-21,23,25,33,42H,4-5,12,15-19,22H2,1-3H3,(H,44,45)/t23-,33-/m0/s1
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NOVARTIS AG

US Patent


Assay Description
Chinese hamster ovary (CHO) cells overexpressing soluble guanylate cyclase were generated to test the effect of sGC activators in a cellular context....


US Patent US10550102 (2020)


BindingDB Entry DOI: 10.7270/Q2PC34SQ
More data for this
Ligand-Target Pair
Soluble Guanylate Cyclases


(Homo sapiens (Human))
BDBM430942
PNG
(US10550102, Example (+)-52-3)
Show SMILES CCc1c(cnn1-c1cccc(n1)-c1cccc2CCC(Nc3ccc(C4CCN(CC4)C(=O)OCC=C)c(CC)c3)c12)C(O)=O
Show InChI InChI=1S/C37H41N5O4/c1-4-21-46-37(45)41-19-17-25(18-20-41)28-15-14-27(22-24(28)5-2)39-32-16-13-26-9-7-10-29(35(26)32)31-11-8-12-34(40-31)42-33(6-3)30(23-38-42)36(43)44/h4,7-12,14-15,22-23,25,32,39H,1,5-6,13,16-21H2,2-3H3,(H,43,44)
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NOVARTIS AG

US Patent


Assay Description
Chinese hamster ovary (CHO) cells overexpressing soluble guanylate cyclase were generated to test the effect of sGC activators in a cellular context....


US Patent US10550102 (2020)


BindingDB Entry DOI: 10.7270/Q2PC34SQ
More data for this
Ligand-Target Pair
Soluble Guanylate Cyclases


(Homo sapiens (Human))
BDBM430951
PNG
(US10550102, Example 34b)
Show SMILES CCOC(=O)c1cnn(c1C)-c1cccc(n1)-c1cccc2OCC(Nc3ccc(cc3C)C3CCN(CC3)C(=O)C3CC3)c12
Show InChI InChI=1S/C36H39N5O4/c1-4-44-36(43)28-20-37-41(23(28)3)33-10-6-8-30(39-33)27-7-5-9-32-34(27)31(21-45-32)38-29-14-13-26(19-22(29)2)24-15-17-40(18-16-24)35(42)25-11-12-25/h5-10,13-14,19-20,24-25,31,38H,4,11-12,15-18,21H2,1-3H3
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NOVARTIS AG

US Patent


Assay Description
Chinese hamster ovary (CHO) cells overexpressing soluble guanylate cyclase were generated to test the effect of sGC activators in a cellular context....


US Patent US10550102 (2020)


BindingDB Entry DOI: 10.7270/Q2PC34SQ
More data for this
Ligand-Target Pair
Soluble Guanylate Cyclases


(Homo sapiens (Human))
BDBM430962
PNG
(US10550102, Example (-)-36-2)
Show SMILES CCc1c(cnn1-c1cccc(n1)-c1cccc2OCC(Nc3ccc(C4CCN(CC4)C(=O)C4CC4)c(CC)c3)c12)C(O)=O
Show InChI InChI=1S/C36H39N5O4/c1-3-22-19-25(13-14-26(22)23-15-17-40(18-16-23)35(42)24-11-12-24)38-30-21-45-32-9-5-7-27(34(30)32)29-8-6-10-33(39-29)41-31(4-2)28(20-37-41)36(43)44/h5-10,13-14,19-20,23-24,30,38H,3-4,11-12,15-18,21H2,1-2H3,(H,43,44)
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NOVARTIS AG

US Patent


Assay Description
Chinese hamster ovary (CHO) cells overexpressing soluble guanylate cyclase were generated to test the effect of sGC activators in a cellular context....


US Patent US10550102 (2020)


BindingDB Entry DOI: 10.7270/Q2PC34SQ
More data for this
Ligand-Target Pair
Soluble Guanylate Cyclases


(Homo sapiens (Human))
BDBM430963
PNG
(US10550102, Example (-)-53-4)
Show SMILES CCOC(=O)c1cnn(c1C)-c1cccc(c1)-c1cccc2CCC(Cc3ccc(cc3C)C3CCN(CC3)C(=O)C3CC3)c12
Show InChI InChI=1S/C39H43N3O3/c1-4-45-39(44)36-24-40-42(26(36)3)34-9-5-8-32(23-34)35-10-6-7-28-11-16-33(37(28)35)22-30-14-15-31(21-25(30)2)27-17-19-41(20-18-27)38(43)29-12-13-29/h5-10,14-15,21,23-24,27,29,33H,4,11-13,16-20,22H2,1-3H3
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NOVARTIS AG

US Patent


Assay Description
Chinese hamster ovary (CHO) cells overexpressing soluble guanylate cyclase were generated to test the effect of sGC activators in a cellular context....


US Patent US10550102 (2020)


BindingDB Entry DOI: 10.7270/Q2PC34SQ
More data for this
Ligand-Target Pair
Soluble Guanylate Cyclases


(Homo sapiens (Human))
BDBM430966
PNG
(US10550102, Example 37. b). (-))
Show SMILES Cc1c(cnn1-c1cccc(n1)-c1cccc2CCC(Cc3ccc(cc3C)C3CCN(CC3)C(=O)C3CC3)c12)C(O)=O
Show InChI InChI=1S/C36H38N4O3/c1-22-19-28(24-15-17-39(18-16-24)35(41)26-10-11-26)13-12-27(22)20-29-14-9-25-5-3-6-30(34(25)29)32-7-4-8-33(38-32)40-23(2)31(21-37-40)36(42)43/h3-8,12-13,19,21,24,26,29H,9-11,14-18,20H2,1-2H3,(H,42,43)
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NOVARTIS AG

US Patent


Assay Description
Chinese hamster ovary (CHO) cells overexpressing soluble guanylate cyclase were generated to test the effect of sGC activators in a cellular context....


US Patent US10550102 (2020)


BindingDB Entry DOI: 10.7270/Q2PC34SQ
More data for this
Ligand-Target Pair
Soluble Guanylate Cyclases


(Homo sapiens (Human))
BDBM430991
PNG
(Example 62-A. (+-)-Ethyl 1-(6-(3-((tert-butoxycarb...)
Show SMILES Cc1c(cnn1-c1cccc(n1)-c1cccc2CCC(Nc3ncc(cc3C)C3CCN(CC3)C(=O)C3CC3)c12)C(O)=O
Show InChI InChI=1S/C34H36N6O3/c1-20-17-25(22-13-15-39(16-14-22)33(41)24-9-10-24)18-35-32(20)38-29-12-11-23-5-3-6-26(31(23)29)28-7-4-8-30(37-28)40-21(2)27(19-36-40)34(42)43/h3-8,17-19,22,24,29H,9-16H2,1-2H3,(H,35,38)(H,42,43)
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NOVARTIS AG

US Patent


Assay Description
Chinese hamster ovary (CHO) cells overexpressing soluble guanylate cyclase were generated to test the effect of sGC activators in a cellular context....


US Patent US10550102 (2020)


BindingDB Entry DOI: 10.7270/Q2PC34SQ
More data for this
Ligand-Target Pair
Soluble Guanylate Cyclases


(Homo sapiens (Human))
BDBM430994
PNG
(US10550102, Example 40-3 (+))
Show SMILES CCC[C@H](O)C(=O)N1CCC(CC1)c1ccc(CC2CCc3cccc(c23)-c2cccc(n2)-n2ncc(C(O)=O)c2CC)c(C)c1
Show InChI InChI=1S/C38H44N4O4/c1-4-8-34(43)37(44)41-19-17-25(18-20-41)28-15-14-27(24(3)21-28)22-29-16-13-26-9-6-10-30(36(26)29)32-11-7-12-35(40-32)42-33(5-2)31(23-39-42)38(45)46/h6-7,9-12,14-15,21,23,25,29,34,43H,4-5,8,13,16-20,22H2,1-3H3,(H,45,46)/t29?,34-/m0/s1
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NOVARTIS AG

US Patent


Assay Description
Chinese hamster ovary (CHO) cells overexpressing soluble guanylate cyclase were generated to test the effect of sGC activators in a cellular context....


US Patent US10550102 (2020)


BindingDB Entry DOI: 10.7270/Q2PC34SQ
More data for this
Ligand-Target Pair
Soluble Guanylate Cyclases


(Homo sapiens (Human))
BDBM430996
PNG
(US10550102, Example 41. b). (-))
Show SMILES CCc1c(cnn1-c1cccc(n1)-c1cccc2CCC(Cc3ccc(C4CCN(CC4)C(=O)OC)c(CC)c3)c12)C(O)=O
Show InChI InChI=1S/C36H40N4O4/c1-4-24-20-23(12-15-28(24)25-16-18-39(19-17-25)36(43)44-3)21-27-14-13-26-8-6-9-29(34(26)27)31-10-7-11-33(38-31)40-32(5-2)30(22-37-40)35(41)42/h6-12,15,20,22,25,27H,4-5,13-14,16-19,21H2,1-3H3,(H,41,42)
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NOVARTIS AG

US Patent


Assay Description
Chinese hamster ovary (CHO) cells overexpressing soluble guanylate cyclase were generated to test the effect of sGC activators in a cellular context....


US Patent US10550102 (2020)


BindingDB Entry DOI: 10.7270/Q2PC34SQ
More data for this
Ligand-Target Pair
Soluble Guanylate Cyclases


(Homo sapiens (Human))
BDBM431008
PNG
(US10550102, Example 44 (+))
Show SMILES Cc1c(cnn1-c1cccc(c1)-c1cccc2CCC(Nc3ccc(cc3C)C3CCN(CC3)C(=O)C3CC3)c12)C(O)=O
Show InChI InChI=1S/C36H38N4O3/c1-22-19-27(24-15-17-39(18-16-24)35(41)26-9-10-26)12-13-32(22)38-33-14-11-25-5-4-8-30(34(25)33)28-6-3-7-29(20-28)40-23(2)31(21-37-40)36(42)43/h3-8,12-13,19-21,24,26,33,38H,9-11,14-18H2,1-2H3,(H,42,43)
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NOVARTIS AG

US Patent


Assay Description
Chinese hamster ovary (CHO) cells overexpressing soluble guanylate cyclase were generated to test the effect of sGC activators in a cellular context....


US Patent US10550102 (2020)


BindingDB Entry DOI: 10.7270/Q2PC34SQ
More data for this
Ligand-Target Pair
Soluble Guanylate Cyclases


(Homo sapiens (Human))
BDBM431010
PNG
(US10550102, Example 44 (-))
Show SMILES Cc1c(cnn1-c1cccc(c1)-c1cccc2CCC(Nc3ccc(cc3C)C3CCN(CC3)C(=O)C3CC3)c12)C(O)=O
Show InChI InChI=1S/C36H38N4O3/c1-22-19-27(24-15-17-39(18-16-24)35(41)26-9-10-26)12-13-32(22)38-33-14-11-25-5-4-8-30(34(25)33)28-6-3-7-29(20-28)40-23(2)31(21-37-40)36(42)43/h3-8,12-13,19-21,24,26,33,38H,9-11,14-18H2,1-2H3,(H,42,43)
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NOVARTIS AG

US Patent


Assay Description
Chinese hamster ovary (CHO) cells overexpressing soluble guanylate cyclase were generated to test the effect of sGC activators in a cellular context....


US Patent US10550102 (2020)


BindingDB Entry DOI: 10.7270/Q2PC34SQ
More data for this
Ligand-Target Pair
Soluble Guanylate Cyclases


(Homo sapiens (Human))
BDBM430642
PNG
(US10550102, Example 7a)
Show SMILES Cc1c(cnn1-c1cccc(n1)-c1cccc2CCC(Nc3ccc(cc3C)C3CCN(CC3)C(=O)C3CC3)c12)C(O)=O
Show InChI InChI=1S/C35H37N5O3/c1-21-19-26(23-15-17-39(18-16-23)34(41)25-9-10-25)12-13-29(21)37-31-14-11-24-5-3-6-27(33(24)31)30-7-4-8-32(38-30)40-22(2)28(20-36-40)35(42)43/h3-8,12-13,19-20,23,25,31,37H,9-11,14-18H2,1-2H3,(H,42,43)
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NOVARTIS AG

US Patent


Assay Description
Chinese hamster ovary (CHO) cells overexpressing soluble guanylate cyclase were generated to test the effect of sGC activators in a cellular context....


US Patent US10550102 (2020)


BindingDB Entry DOI: 10.7270/Q2PC34SQ
More data for this
Ligand-Target Pair
Soluble Guanylate Cyclases


(Homo sapiens (Human))
BDBM430678
PNG
(Example 2-A. (+)-(S)-Ethyl-1-(3-(3-(4-(1-(cyclopro...)
Show SMILES Cc1c(cnn1-c1cccc(c1)-c1cccc2CC[C@H](Oc3ccc(cc3C)C3CCN(CC3)C(=O)C3CC3)c12)C(O)=O
Show InChI InChI=1S/C36H37N3O4/c1-22-19-27(24-15-17-38(18-16-24)35(40)26-9-10-26)12-13-32(22)43-33-14-11-25-5-4-8-30(34(25)33)28-6-3-7-29(20-28)39-23(2)31(21-37-39)36(41)42/h3-8,12-13,19-21,24,26,33H,9-11,14-18H2,1-2H3,(H,41,42)/t33-/m0/s1
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NOVARTIS AG

US Patent


Assay Description
Chinese hamster ovary (CHO) cells overexpressing soluble guanylate cyclase were generated to test the effect of sGC activators in a cellular context....


US Patent US10550102 (2020)


BindingDB Entry DOI: 10.7270/Q2PC34SQ
More data for this
Ligand-Target Pair
Soluble Guanylate Cyclases


(Homo sapiens (Human))
BDBM430870
PNG
(US10550102, Example 11-2)
Show SMILES OC(=O)c1cnn(c1C(F)(F)F)-c1cccc(n1)-c1cccc2CCC(Nc3ccc(cc3)C3CCN(CC3)C(=O)C3CC3)c12
Show InChI InChI=1S/C34H32F3N5O3/c35-34(36,37)31-26(33(44)45)19-38-42(31)29-6-2-5-27(40-29)25-4-1-3-22-11-14-28(30(22)25)39-24-12-9-20(10-13-24)21-15-17-41(18-16-21)32(43)23-7-8-23/h1-6,9-10,12-13,19,21,23,28,39H,7-8,11,14-18H2,(H,44,45)
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NOVARTIS AG

US Patent


Assay Description
Chinese hamster ovary (CHO) cells overexpressing soluble guanylate cyclase were generated to test the effect of sGC activators in a cellular context....


US Patent US10550102 (2020)


BindingDB Entry DOI: 10.7270/Q2PC34SQ
More data for this
Ligand-Target Pair
Soluble Guanylate Cyclases


(Homo sapiens (Human))
BDBM430881
PNG
(US10550102, Example 5-9)
Show SMILES CCc1c(cnn1-c1cccc(n1)-c1cccc2CC[C@H](Oc3ccc(C4CCN(CC4)C(=O)C4CC4)c(CC)c3)c12)C(O)=O
Show InChI InChI=1S/C37H40N4O4/c1-3-23-21-27(14-15-28(23)24-17-19-40(20-18-24)36(42)26-11-12-26)45-33-16-13-25-7-5-8-29(35(25)33)31-9-6-10-34(39-31)41-32(4-2)30(22-38-41)37(43)44/h5-10,14-15,21-22,24,26,33H,3-4,11-13,16-20H2,1-2H3,(H,43,44)/t33-/m0/s1
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NOVARTIS AG

US Patent


Assay Description
Chinese hamster ovary (CHO) cells overexpressing soluble guanylate cyclase were generated to test the effect of sGC activators in a cellular context....


US Patent US10550102 (2020)


BindingDB Entry DOI: 10.7270/Q2PC34SQ
More data for this
Ligand-Target Pair
Soluble Guanylate Cyclases


(Homo sapiens (Human))
BDBM430903
PNG
(US10550102, Example (+)-20-2)
Show SMILES CCc1c(cnn1-c1cccc(n1)-c1cccc2C(C)CN(Cc3ccc(cc3C)C3CCN(CC3)C(=O)C3CC3)c12)C(O)=O
Show InChI InChI=1S/C37H41N5O3/c1-4-33-31(37(44)45)20-38-42(33)34-10-6-9-32(39-34)30-8-5-7-29-24(3)21-41(35(29)30)22-28-14-13-27(19-23(28)2)25-15-17-40(18-16-25)36(43)26-11-12-26/h5-10,13-14,19-20,24-26H,4,11-12,15-18,21-22H2,1-3H3,(H,44,45)
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NOVARTIS AG

US Patent


Assay Description
Chinese hamster ovary (CHO) cells overexpressing soluble guanylate cyclase were generated to test the effect of sGC activators in a cellular context....


US Patent US10550102 (2020)


BindingDB Entry DOI: 10.7270/Q2PC34SQ
More data for this
Ligand-Target Pair
Soluble Guanylate Cyclases


(Homo sapiens (Human))
BDBM430907
PNG
(US10550102, Example (+)-20-3)
Show SMILES CCc1cc(CN2CC(C)c3cccc(c23)-c2cccc(n2)-n2ncc(C(O)=O)c2C)ccc1C1CCN(CC1)C(=O)C1CC1
Show InChI InChI=1S/C37H41N5O3/c1-4-26-19-25(11-14-30(26)27-15-17-40(18-16-27)36(43)28-12-13-28)22-41-21-23(2)29-7-5-8-31(35(29)41)33-9-6-10-34(39-33)42-24(3)32(20-38-42)37(44)45/h5-11,14,19-20,23,27-28H,4,12-13,15-18,21-22H2,1-3H3,(H,44,45)
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NOVARTIS AG

US Patent


Assay Description
Chinese hamster ovary (CHO) cells overexpressing soluble guanylate cyclase were generated to test the effect of sGC activators in a cellular context....


US Patent US10550102 (2020)


BindingDB Entry DOI: 10.7270/Q2PC34SQ
More data for this
Ligand-Target Pair
Soluble Guanylate Cyclases


(Homo sapiens (Human))
BDBM430916
PNG
(US10550102, Example 48a)
Show SMILES CCc1c(cnn1-c1cccc(n1)-c1cccc2CCC(Nc3ccc(C4CCN(CC4)C(=O)[C@H](C)O)c(CC)c3)c12)C(O)=O
Show InChI InChI=1S/C36H41N5O4/c1-4-23-20-26(13-14-27(23)24-16-18-40(19-17-24)35(43)22(3)42)38-31-15-12-25-8-6-9-28(34(25)31)30-10-7-11-33(39-30)41-32(5-2)29(21-37-41)36(44)45/h6-11,13-14,20-22,24,31,38,42H,4-5,12,15-19H2,1-3H3,(H,44,45)/t22-,31?/m0/s1
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NOVARTIS AG

US Patent


Assay Description
Chinese hamster ovary (CHO) cells overexpressing soluble guanylate cyclase were generated to test the effect of sGC activators in a cellular context....


US Patent US10550102 (2020)


BindingDB Entry DOI: 10.7270/Q2PC34SQ
More data for this
Ligand-Target Pair
Soluble Guanylate Cyclases


(Homo sapiens (Human))
BDBM430917
PNG
(US10550102, Example 22b)
Show SMILES CCOC(=O)c1cnn(c1CC)-c1cccc(n1)-c1cccc2CC(C)Nc12
Show InChI InChI=1S/C22H24N4O2/c1-4-19-17(22(27)28-5-2)13-23-26(19)20-11-7-10-18(25-20)16-9-6-8-15-12-14(3)24-21(15)16/h6-11,13-14,24H,4-5,12H2,1-3H3
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NOVARTIS AG

US Patent


Assay Description
Chinese hamster ovary (CHO) cells overexpressing soluble guanylate cyclase were generated to test the effect of sGC activators in a cellular context....


US Patent US10550102 (2020)


BindingDB Entry DOI: 10.7270/Q2PC34SQ
More data for this
Ligand-Target Pair
Soluble Guanylate Cyclases


(Homo sapiens (Human))
BDBM430937
PNG
(US10550102, Example 31-2)
Show SMILES CC[C@H](O)C(=O)N1CCC(CC1)c1ccc(O[C@H]2CCc3cccc(c23)-c2cccc(n2)-n2ncc(C(O)=O)c2CC)cc1CC
Show InChI InChI=1S/C37H42N4O5/c1-4-23-21-26(14-15-27(23)24-17-19-40(20-18-24)36(43)32(42)6-3)46-33-16-13-25-9-7-10-28(35(25)33)30-11-8-12-34(39-30)41-31(5-2)29(22-38-41)37(44)45/h7-12,14-15,21-22,24,32-33,42H,4-6,13,16-20H2,1-3H3,(H,44,45)/t32-,33-/m0/s1
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NOVARTIS AG

US Patent


Assay Description
Chinese hamster ovary (CHO) cells overexpressing soluble guanylate cyclase were generated to test the effect of sGC activators in a cellular context....


US Patent US10550102 (2020)


BindingDB Entry DOI: 10.7270/Q2PC34SQ
More data for this
Ligand-Target Pair
Soluble Guanylate Cyclases


(Homo sapiens (Human))
BDBM430947
PNG
(Example 33-A. (S)-1-(6-(3-(4-(1-(tert-Butoxycarbon...)
Show SMILES CCc1c(cnn1-c1cccc(n1)-c1cccc2CC[C@H](Oc3ccc(C4CCN(CC4)C(=O)C4(O)CC4)c(CC)c3)c12)C(O)=O
Show InChI InChI=1S/C37H40N4O5/c1-3-23-21-26(12-13-27(23)24-15-19-40(20-16-24)36(44)37(45)17-18-37)46-32-14-11-25-7-5-8-28(34(25)32)30-9-6-10-33(39-30)41-31(4-2)29(22-38-41)35(42)43/h5-10,12-13,21-22,24,32,45H,3-4,11,14-20H2,1-2H3,(H,42,43)/t32-/m0/s1
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NOVARTIS AG

US Patent


Assay Description
Chinese hamster ovary (CHO) cells overexpressing soluble guanylate cyclase were generated to test the effect of sGC activators in a cellular context....


US Patent US10550102 (2020)


BindingDB Entry DOI: 10.7270/Q2PC34SQ
More data for this
Ligand-Target Pair
Soluble Guanylate Cyclases


(Homo sapiens (Human))
BDBM430950
PNG
(US10550102, Example (-)-53-1)
Show SMILES CCc1c(cnn1-c1cccc(n1)-c1cccc2CCC(Nc3ccc(C4CCN(CC4)C(=O)C4CC4)c(CC)c3)c12)C(O)=O
Show InChI InChI=1S/C37H41N5O3/c1-3-23-21-27(14-15-28(23)24-17-19-41(20-18-24)36(43)26-11-12-26)39-32-16-13-25-7-5-8-29(35(25)32)31-9-6-10-34(40-31)42-33(4-2)30(22-38-42)37(44)45/h5-10,14-15,21-22,24,26,32,39H,3-4,11-13,16-20H2,1-2H3,(H,44,45)
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NOVARTIS AG

US Patent


Assay Description
Chinese hamster ovary (CHO) cells overexpressing soluble guanylate cyclase were generated to test the effect of sGC activators in a cellular context....


US Patent US10550102 (2020)


BindingDB Entry DOI: 10.7270/Q2PC34SQ
More data for this
Ligand-Target Pair
Soluble Guanylate Cyclases


(Homo sapiens (Human))
BDBM430958
PNG
(US10550102, Example (-)-36-1)
Show SMILES CCc1cc(NC2COc3cccc(c23)-c2cccc(n2)-n2ncc(C(O)=O)c2C(F)(F)F)ccc1C1CCN(CC1)C(=O)C1CC1
Show InChI InChI=1S/C35H34F3N5O4/c1-2-20-17-23(11-12-24(20)21-13-15-42(16-14-21)33(44)22-9-10-22)40-28-19-47-29-7-3-5-25(31(28)29)27-6-4-8-30(41-27)43-32(35(36,37)38)26(18-39-43)34(45)46/h3-8,11-12,17-18,21-22,28,40H,2,9-10,13-16,19H2,1H3,(H,45,46)
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NOVARTIS AG

US Patent


Assay Description
Chinese hamster ovary (CHO) cells overexpressing soluble guanylate cyclase were generated to test the effect of sGC activators in a cellular context....


US Patent US10550102 (2020)


BindingDB Entry DOI: 10.7270/Q2PC34SQ
More data for this
Ligand-Target Pair
Soluble Guanylate Cyclases


(Homo sapiens (Human))
BDBM430969
PNG
(US10550102, Example 55-1 (-))
Show SMILES CCc1cc(CC2CCc3cccc(c23)-c2cccc(c2)-n2ncc(C(O)=O)c2C)ccc1C1CCN(CC1)C(=O)C1CC1
Show InChI InChI=1S/C38H41N3O3/c1-3-26-20-25(10-15-33(26)27-16-18-40(19-17-27)37(42)29-12-13-29)21-31-14-11-28-6-5-9-34(36(28)31)30-7-4-8-32(22-30)41-24(2)35(23-39-41)38(43)44/h4-10,15,20,22-23,27,29,31H,3,11-14,16-19,21H2,1-2H3,(H,43,44)
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NOVARTIS AG

US Patent


Assay Description
Chinese hamster ovary (CHO) cells overexpressing soluble guanylate cyclase were generated to test the effect of sGC activators in a cellular context....


US Patent US10550102 (2020)


BindingDB Entry DOI: 10.7270/Q2PC34SQ
More data for this
Ligand-Target Pair
Soluble Guanylate Cyclases


(Homo sapiens (Human))
BDBM430972
PNG
(US10550102, Example 38-2 (-))
Show SMILES CCc1cc(CC2CCc3cccc(c23)-c2cccc(n2)-n2ncc(C(O)=O)c2C)ccc1C1CCN(CC1)C(=O)C1CC1
Show InChI InChI=1S/C37H40N4O3/c1-3-25-20-24(10-15-30(25)26-16-18-40(19-17-26)36(42)28-12-13-28)21-29-14-11-27-6-4-7-31(35(27)29)33-8-5-9-34(39-33)41-23(2)32(22-38-41)37(43)44/h4-10,15,20,22,26,28-29H,3,11-14,16-19,21H2,1-2H3,(H,43,44)
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NOVARTIS AG

US Patent


Assay Description
Chinese hamster ovary (CHO) cells overexpressing soluble guanylate cyclase were generated to test the effect of sGC activators in a cellular context....


US Patent US10550102 (2020)


BindingDB Entry DOI: 10.7270/Q2PC34SQ
More data for this
Ligand-Target Pair
Soluble Guanylate Cyclases


(Homo sapiens (Human))
BDBM430976
PNG
(US10550102, Example 38-3 (+))
Show SMILES CCc1c(cnn1-c1cccc(n1)-c1cccc2CCC(Cc3ccc(cc3C)C3CCN(CC3)C(=O)C3CC3)c12)C(O)=O
Show InChI InChI=1S/C37H40N4O3/c1-3-33-31(37(43)44)22-38-41(33)34-9-5-8-32(39-34)30-7-4-6-25-10-15-29(35(25)30)21-27-13-14-28(20-23(27)2)24-16-18-40(19-17-24)36(42)26-11-12-26/h4-9,13-14,20,22,24,26,29H,3,10-12,15-19,21H2,1-2H3,(H,43,44)
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NOVARTIS AG

US Patent


Assay Description
Chinese hamster ovary (CHO) cells overexpressing soluble guanylate cyclase were generated to test the effect of sGC activators in a cellular context....


US Patent US10550102 (2020)


BindingDB Entry DOI: 10.7270/Q2PC34SQ
More data for this
Ligand-Target Pair
Soluble Guanylate Cyclases


(Homo sapiens (Human))
BDBM430978
PNG
(US10550102, Example 38-3 (-))
Show SMILES CCc1c(cnn1-c1cccc(n1)-c1cccc2CCC(Cc3ccc(cc3C)C3CCN(CC3)C(=O)C3CC3)c12)C(O)=O
Show InChI InChI=1S/C37H40N4O3/c1-3-33-31(37(43)44)22-38-41(33)34-9-5-8-32(39-34)30-7-4-6-25-10-15-29(35(25)30)21-27-13-14-28(20-23(27)2)24-16-18-40(19-17-24)36(42)26-11-12-26/h4-9,13-14,20,22,24,26,29H,3,10-12,15-19,21H2,1-2H3,(H,43,44)
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NOVARTIS AG

US Patent


Assay Description
Chinese hamster ovary (CHO) cells overexpressing soluble guanylate cyclase were generated to test the effect of sGC activators in a cellular context....


US Patent US10550102 (2020)


BindingDB Entry DOI: 10.7270/Q2PC34SQ
More data for this
Ligand-Target Pair
Soluble Guanylate Cyclases


(Homo sapiens (Human))
BDBM430981
PNG
(US10550102, Example 58. b). (+))
Show SMILES CCOC(=O)c1cnn(c1C)-c1cccc(n1)-c1cccc2CCC(Nc3ccc(cc3C)C3CCN(CC3)c3nnc(C)o3)c12
Show InChI InChI=1S/C36H39N7O3/c1-5-45-35(44)29-21-37-43(23(29)3)33-11-7-10-31(39-33)28-9-6-8-26-12-15-32(34(26)28)38-30-14-13-27(20-22(30)2)25-16-18-42(19-17-25)36-41-40-24(4)46-36/h6-11,13-14,20-21,25,32,38H,5,12,15-19H2,1-4H3
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NOVARTIS AG

US Patent


Assay Description
Chinese hamster ovary (CHO) cells overexpressing soluble guanylate cyclase were generated to test the effect of sGC activators in a cellular context....


US Patent US10550102 (2020)


BindingDB Entry DOI: 10.7270/Q2PC34SQ
More data for this
Ligand-Target Pair
Soluble Guanylate Cyclases


(Homo sapiens (Human))
BDBM430987
PNG
(US10550102, Example 61. b). (enantiomer-1) | US105...)
Show SMILES OC(=O)c1cnn(c1C(F)(F)F)-c1cccc(n1)-c1cccc2CCC(Nc3ccc(cc3C(F)(F)F)C3CCN(CC3)C(=O)C3CC3)c12
Show InChI InChI=1S/C35H31F6N5O3/c36-34(37,38)25-17-22(19-13-15-45(16-14-19)32(47)21-7-8-21)10-11-27(25)43-28-12-9-20-3-1-4-23(30(20)28)26-5-2-6-29(44-26)46-31(35(39,40)41)24(18-42-46)33(48)49/h1-6,10-11,17-19,21,28,43H,7-9,12-16H2,(H,48,49)
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NOVARTIS AG

US Patent


Assay Description
Chinese hamster ovary (CHO) cells overexpressing soluble guanylate cyclase were generated to test the effect of sGC activators in a cellular context....


US Patent US10550102 (2020)


BindingDB Entry DOI: 10.7270/Q2PC34SQ
More data for this
Ligand-Target Pair
Soluble Guanylate Cyclases


(Homo sapiens (Human))
BDBM430987
PNG
(US10550102, Example 61. b). (enantiomer-1) | US105...)
Show SMILES OC(=O)c1cnn(c1C(F)(F)F)-c1cccc(n1)-c1cccc2CCC(Nc3ccc(cc3C(F)(F)F)C3CCN(CC3)C(=O)C3CC3)c12
Show InChI InChI=1S/C35H31F6N5O3/c36-34(37,38)25-17-22(19-13-15-45(16-14-19)32(47)21-7-8-21)10-11-27(25)43-28-12-9-20-3-1-4-23(30(20)28)26-5-2-6-29(44-26)46-31(35(39,40)41)24(18-42-46)33(48)49/h1-6,10-11,17-19,21,28,43H,7-9,12-16H2,(H,48,49)
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NOVARTIS AG

US Patent


Assay Description
Chinese hamster ovary (CHO) cells overexpressing soluble guanylate cyclase were generated to test the effect of sGC activators in a cellular context....


US Patent US10550102 (2020)


BindingDB Entry DOI: 10.7270/Q2PC34SQ
More data for this
Ligand-Target Pair
Soluble Guanylate Cyclases


(Homo sapiens (Human))
BDBM431001
PNG
(US10550102, Example 64-3)
Show SMILES CCc1c(cnn1-c1cccc(n1)-c1cccc2CC[C@H](Oc3ccc(C4CCN(CC4)C(=O)OC(C)C)c(CC)c3)c12)C(O)=O
Show InChI InChI=1S/C37H42N4O5/c1-5-24-21-27(14-15-28(24)25-17-19-40(20-18-25)37(44)45-23(3)4)46-33-16-13-26-9-7-10-29(35(26)33)31-11-8-12-34(39-31)41-32(6-2)30(22-38-41)36(42)43/h7-12,14-15,21-23,25,33H,5-6,13,16-20H2,1-4H3,(H,42,43)/t33-/m0/s1
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NOVARTIS AG

US Patent


Assay Description
Chinese hamster ovary (CHO) cells overexpressing soluble guanylate cyclase were generated to test the effect of sGC activators in a cellular context....


US Patent US10550102 (2020)


BindingDB Entry DOI: 10.7270/Q2PC34SQ
More data for this
Ligand-Target Pair
Soluble Guanylate Cyclases


(Homo sapiens (Human))
BDBM431002
PNG
(US10550102, Example 42. b). (+))
Show SMILES CCc1c(cnn1-c1cccc(n1)-c1cccc2CCC(Cc3ccc(cc3C)C3CCN(CC3)C(=O)OC)c12)C(O)=O
Show InChI InChI=1S/C35H38N4O4/c1-4-31-29(34(40)41)21-36-39(31)32-10-6-9-30(37-32)28-8-5-7-24-11-14-27(33(24)28)20-25-12-13-26(19-22(25)2)23-15-17-38(18-16-23)35(42)43-3/h5-10,12-13,19,21,23,27H,4,11,14-18,20H2,1-3H3,(H,40,41)
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NOVARTIS AG

US Patent


Assay Description
Chinese hamster ovary (CHO) cells overexpressing soluble guanylate cyclase were generated to test the effect of sGC activators in a cellular context....


US Patent US10550102 (2020)


BindingDB Entry DOI: 10.7270/Q2PC34SQ
More data for this
Ligand-Target Pair
Soluble Guanylate Cyclases


(Homo sapiens (Human))
BDBM431004
PNG
(US10550102, Example 43 (+))
Show SMILES Cc1cc2CCC(Nc3ccc(cc3C)C3CCN(CC3)C(=O)C3CC3)c2c(c1)-c1cccc(n1)-n1ncc(C(O)=O)c1C(F)(F)F
Show InChI InChI=1S/C36H36F3N5O3/c1-20-16-25-9-11-30(41-28-10-8-24(18-21(28)2)22-12-14-43(15-13-22)34(45)23-6-7-23)32(25)26(17-20)29-4-3-5-31(42-29)44-33(36(37,38)39)27(19-40-44)35(46)47/h3-5,8,10,16-19,22-23,30,41H,6-7,9,11-15H2,1-2H3,(H,46,47)
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NOVARTIS AG

US Patent


Assay Description
Chinese hamster ovary (CHO) cells overexpressing soluble guanylate cyclase were generated to test the effect of sGC activators in a cellular context....


US Patent US10550102 (2020)


BindingDB Entry DOI: 10.7270/Q2PC34SQ
More data for this
Ligand-Target Pair
Soluble Guanylate Cyclases


(Homo sapiens (Human))
BDBM430893
PNG
(US10550102, Example 18)
Show SMILES CCc1c(cnn1-c1cccc(n1)-c1cccc2CCN(Cc3ccc(cc3C)C3CCN(CC3)C(=O)[C@H](C)O)c12)C(O)=O
Show InChI InChI=1S/C35H39N5O4/c1-4-31-29(35(43)44)20-36-40(31)32-10-6-9-30(37-32)28-8-5-7-25-15-18-39(33(25)28)21-27-12-11-26(19-22(27)2)24-13-16-38(17-14-24)34(42)23(3)41/h5-12,19-20,23-24,41H,4,13-18,21H2,1-3H3,(H,43,44)/t23-/m0/s1
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n/an/an/an/a 1.40n/an/an/an/a



NOVARTIS AG

US Patent


Assay Description
Chinese hamster ovary (CHO) cells overexpressing soluble guanylate cyclase were generated to test the effect of sGC activators in a cellular context....


US Patent US10550102 (2020)


BindingDB Entry DOI: 10.7270/Q2PC34SQ
More data for this
Ligand-Target Pair
Soluble Guanylate Cyclases


(Homo sapiens (Human))
BDBM430894
PNG
(US10550102, Example (+)-46-2)
Show SMILES CCC(=O)N1CCC(CC1)c1ccc(NC2CCc3cccc(c23)-c2cccc(n2)-n2ncc(C(O)=O)c2C)c(C)c1
Show InChI InChI=1S/C34H37N5O3/c1-4-32(40)38-17-15-23(16-18-38)25-12-13-28(21(2)19-25)36-30-14-11-24-7-5-8-26(33(24)30)29-9-6-10-31(37-29)39-22(3)27(20-35-39)34(41)42/h5-10,12-13,19-20,23,30,36H,4,11,14-18H2,1-3H3,(H,41,42)
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NOVARTIS AG

US Patent


Assay Description
Chinese hamster ovary (CHO) cells overexpressing soluble guanylate cyclase were generated to test the effect of sGC activators in a cellular context....


US Patent US10550102 (2020)


BindingDB Entry DOI: 10.7270/Q2PC34SQ
More data for this
Ligand-Target Pair
Soluble Guanylate Cyclases


(Homo sapiens (Human))
BDBM430898
PNG
(US10550102, Example (+)-46-3)
Show SMILES Cc1c(cnn1-c1cccc(n1)-c1cccc2CCC(Nc3ccc(cc3C)C3CCN(CC3)C(=O)CC3CC3)c12)C(O)=O
Show InChI InChI=1S/C36H39N5O3/c1-22-19-27(25-15-17-40(18-16-25)34(42)20-24-9-10-24)12-13-30(22)38-32-14-11-26-5-3-6-28(35(26)32)31-7-4-8-33(39-31)41-23(2)29(21-37-41)36(43)44/h3-8,12-13,19,21,24-25,32,38H,9-11,14-18,20H2,1-2H3,(H,43,44)
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n/an/an/an/a 1n/an/an/an/a



NOVARTIS AG

US Patent


Assay Description
Chinese hamster ovary (CHO) cells overexpressing soluble guanylate cyclase were generated to test the effect of sGC activators in a cellular context....


US Patent US10550102 (2020)


BindingDB Entry DOI: 10.7270/Q2PC34SQ
More data for this
Ligand-Target Pair
Soluble Guanylate Cyclases


(Homo sapiens (Human))
BDBM430909
PNG
(US10550102, Example (-)-20-3)
Show SMILES CCc1cc(CN2CC(C)c3cccc(c23)-c2cccc(n2)-n2ncc(C(O)=O)c2C)ccc1C1CCN(CC1)C(=O)C1CC1
Show InChI InChI=1S/C37H41N5O3/c1-4-26-19-25(11-14-30(26)27-15-17-40(18-16-27)36(43)28-12-13-28)22-41-21-23(2)29-7-5-8-31(35(29)41)33-9-6-10-34(39-33)42-24(3)32(20-38-42)37(44)45/h5-11,14,19-20,23,27-28H,4,12-13,15-18,21-22H2,1-3H3,(H,44,45)
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NOVARTIS AG

US Patent


Assay Description
Chinese hamster ovary (CHO) cells overexpressing soluble guanylate cyclase were generated to test the effect of sGC activators in a cellular context....


US Patent US10550102 (2020)


BindingDB Entry DOI: 10.7270/Q2PC34SQ
More data for this
Ligand-Target Pair
Soluble Guanylate Cyclases


(Homo sapiens (Human))
BDBM430912
PNG
(US10550102, Example 47a)
Show SMILES C[C@H](O)C(=O)N1CCC(CC1)c1ccc(NC2CCc3cccc(c23)-c2cccc(n2)-n2ncc(C(O)=O)c2C)c(C)c1
Show InChI InChI=1S/C34H37N5O4/c1-20-18-25(23-14-16-38(17-15-23)33(41)22(3)40)11-12-28(20)36-30-13-10-24-6-4-7-26(32(24)30)29-8-5-9-31(37-29)39-21(2)27(19-35-39)34(42)43/h4-9,11-12,18-19,22-23,30,36,40H,10,13-17H2,1-3H3,(H,42,43)/t22-,30?/m0/s1
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NOVARTIS AG

US Patent


Assay Description
Chinese hamster ovary (CHO) cells overexpressing soluble guanylate cyclase were generated to test the effect of sGC activators in a cellular context....


US Patent US10550102 (2020)


BindingDB Entry DOI: 10.7270/Q2PC34SQ
More data for this
Ligand-Target Pair
Soluble Guanylate Cyclases


(Homo sapiens (Human))
BDBM430914
PNG
(US10550102, Example 47b)
Show SMILES CCOC(=O)c1cnn(c1C)-c1cccc(n1)-c1cccc2CCC(Nc3ccc(cc3C)C3CCN(CC3)C(=O)[C@H](C)O)c12
Show InChI InChI=1S/C36H41N5O4/c1-5-45-36(44)29-21-37-41(23(29)3)33-11-7-10-31(39-33)28-9-6-8-26-12-15-32(34(26)28)38-30-14-13-27(20-22(30)2)25-16-18-40(19-17-25)35(43)24(4)42/h6-11,13-14,20-21,24-25,32,38,42H,5,12,15-19H2,1-4H3/t24-,32?/m0/s1
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NOVARTIS AG

US Patent


Assay Description
Chinese hamster ovary (CHO) cells overexpressing soluble guanylate cyclase were generated to test the effect of sGC activators in a cellular context....


US Patent US10550102 (2020)


BindingDB Entry DOI: 10.7270/Q2PC34SQ
More data for this
Ligand-Target Pair
Soluble Guanylate Cyclases


(Homo sapiens (Human))
BDBM430920
PNG
(US10550102, Example 49a)
Show SMILES CCC[C@H](O)C(=O)N1CCC(CC1)c1ccc(NC2CCc3cccc(c23)-c2cccc(n2)-n2ncc(C(O)=O)c2CC)cc1CC
Show InChI InChI=1S/C38H45N5O4/c1-4-9-34(44)37(45)42-20-18-25(19-21-42)28-16-15-27(22-24(28)5-2)40-32-17-14-26-10-7-11-29(36(26)32)31-12-8-13-35(41-31)43-33(6-3)30(23-39-43)38(46)47/h7-8,10-13,15-16,22-23,25,32,34,40,44H,4-6,9,14,17-21H2,1-3H3,(H,46,47)/t32?,34-/m0/s1
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NOVARTIS AG

US Patent


Assay Description
Chinese hamster ovary (CHO) cells overexpressing soluble guanylate cyclase were generated to test the effect of sGC activators in a cellular context....


US Patent US10550102 (2020)


BindingDB Entry DOI: 10.7270/Q2PC34SQ
More data for this
Ligand-Target Pair
Soluble Guanylate Cyclases


(Homo sapiens (Human))
BDBM430922
PNG
(US10550102, Example 49b)
Show SMILES CCC[C@H](O)C(=O)N1CCC(CC1)c1ccc(NC2CCc3cccc(c23)-c2cccc(n2)-n2ncc(C(=O)OCC)c2CC)cc1CC
Show InChI InChI=1S/C40H49N5O4/c1-5-11-36(46)39(47)44-22-20-27(21-23-44)30-18-17-29(24-26(30)6-2)42-34-19-16-28-12-9-13-31(38(28)34)33-14-10-15-37(43-33)45-35(7-3)32(25-41-45)40(48)49-8-4/h9-10,12-15,17-18,24-25,27,34,36,42,46H,5-8,11,16,19-23H2,1-4H3/t34?,36-/m0/s1
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NOVARTIS AG

US Patent


Assay Description
Chinese hamster ovary (CHO) cells overexpressing soluble guanylate cyclase were generated to test the effect of sGC activators in a cellular context....


US Patent US10550102 (2020)


BindingDB Entry DOI: 10.7270/Q2PC34SQ
More data for this
Ligand-Target Pair
Soluble Guanylate Cyclases


(Homo sapiens (Human))
BDBM430925
PNG
(US10550102, Example 26)
Show SMILES OC(=O)c1cnn(c1C(F)(F)F)-c1cccc(n1)-c1cccc2ccn(Cc3ccc(cc3)C3CCN(CC3)C(=O)C3CC3)c12
Show InChI InChI=1S/C34H30F3N5O3/c35-34(36,37)31-27(33(44)45)19-38-42(31)29-6-2-5-28(39-29)26-4-1-3-24-15-18-41(30(24)26)20-21-7-9-22(10-8-21)23-13-16-40(17-14-23)32(43)25-11-12-25/h1-10,15,18-19,23,25H,11-14,16-17,20H2,(H,44,45)
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NOVARTIS AG

US Patent


Assay Description
Chinese hamster ovary (CHO) cells overexpressing soluble guanylate cyclase were generated to test the effect of sGC activators in a cellular context....


US Patent US10550102 (2020)


BindingDB Entry DOI: 10.7270/Q2PC34SQ
More data for this
Ligand-Target Pair
Soluble Guanylate Cyclases


(Homo sapiens (Human))
BDBM430927
PNG
(US10550102, Example 27)
Show SMILES CCc1c(cnn1-c1cccc(n1)-c1cccc2ccn(Cc3ccc(C4CCN(CC4)C(=O)C4CC4)c(CC)c3)c12)C(O)=O
Show InChI InChI=1S/C37H39N5O3/c1-3-25-21-24(11-14-29(25)26-15-18-40(19-16-26)36(43)28-12-13-28)23-41-20-17-27-7-5-8-30(35(27)41)32-9-6-10-34(39-32)42-33(4-2)31(22-38-42)37(44)45/h5-11,14,17,20-22,26,28H,3-4,12-13,15-16,18-19,23H2,1-2H3,(H,44,45)
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NOVARTIS AG

US Patent


Assay Description
Chinese hamster ovary (CHO) cells overexpressing soluble guanylate cyclase were generated to test the effect of sGC activators in a cellular context....


US Patent US10550102 (2020)


BindingDB Entry DOI: 10.7270/Q2PC34SQ
More data for this
Ligand-Target Pair
Soluble Guanylate Cyclases


(Homo sapiens (Human))
BDBM430929
PNG
(Example 28-A. Ethyl 1-(6-(1-(4-(1-(cyclopropanecar...)
Show SMILES CCc1cc(Cn2cc(C)c3cccc(-c4cccc(n4)-n4ncc(C(O)=O)c4F)c23)ccc1C1CCN(CC1)C(=O)C1CC1
Show InChI InChI=1S/C36H36FN5O3/c1-3-24-18-23(10-13-28(24)25-14-16-40(17-15-25)35(43)26-11-12-26)21-41-20-22(2)27-6-4-7-29(33(27)41)31-8-5-9-32(39-31)42-34(37)30(19-38-42)36(44)45/h4-10,13,18-20,25-26H,3,11-12,14-17,21H2,1-2H3,(H,44,45)
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NOVARTIS AG

US Patent


Assay Description
Chinese hamster ovary (CHO) cells overexpressing soluble guanylate cyclase were generated to test the effect of sGC activators in a cellular context....


US Patent US10550102 (2020)


BindingDB Entry DOI: 10.7270/Q2PC34SQ
More data for this
Ligand-Target Pair
Soluble Guanylate Cyclases


(Homo sapiens (Human))
BDBM430935
PNG
(US10550102, Example 31-1)
Show SMILES CCC[C@H](O)C(=O)N1CCC(CC1)c1ccc(O[C@H]2CCc3cccc(c23)-c2cccc(n2)-n2ncc(C(O)=O)c2CC)cc1CC
Show InChI InChI=1S/C38H44N4O5/c1-4-9-33(43)37(44)41-20-18-25(19-21-41)28-16-15-27(22-24(28)5-2)47-34-17-14-26-10-7-11-29(36(26)34)31-12-8-13-35(40-31)42-32(6-3)30(23-39-42)38(45)46/h7-8,10-13,15-16,22-23,25,33-34,43H,4-6,9,14,17-21H2,1-3H3,(H,45,46)/t33-,34-/m0/s1
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NOVARTIS AG

US Patent


Assay Description
Chinese hamster ovary (CHO) cells overexpressing soluble guanylate cyclase were generated to test the effect of sGC activators in a cellular context....


US Patent US10550102 (2020)


BindingDB Entry DOI: 10.7270/Q2PC34SQ
More data for this
Ligand-Target Pair
Soluble Guanylate Cyclases


(Homo sapiens (Human))
BDBM430938
PNG
(US10550102, Example (+)-52-2)
Show SMILES CCc1c(cnn1-c1cccc(n1)-c1cccc2CCC(Nc3ccc(C4CCN(CC4)C(=O)OC)c(CC)c3)c12)C(O)=O
Show InChI InChI=1S/C35H39N5O4/c1-4-22-20-25(13-14-26(22)23-16-18-39(19-17-23)35(43)44-3)37-30-15-12-24-8-6-9-27(33(24)30)29-10-7-11-32(38-29)40-31(5-2)28(21-36-40)34(41)42/h6-11,13-14,20-21,23,30,37H,4-5,12,15-19H2,1-3H3,(H,41,42)
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NOVARTIS AG

US Patent


Assay Description
Chinese hamster ovary (CHO) cells overexpressing soluble guanylate cyclase were generated to test the effect of sGC activators in a cellular context....


US Patent US10550102 (2020)


BindingDB Entry DOI: 10.7270/Q2PC34SQ
More data for this
Ligand-Target Pair
Soluble Guanylate Cyclases


(Homo sapiens (Human))
BDBM430952
PNG
(US10550102, Example (+)-53-1)
Show SMILES CCc1c(cnn1-c1cccc(n1)-c1cccc2CCC(Nc3ccc(C4CCN(CC4)C(=O)C4CC4)c(CC)c3)c12)C(O)=O
Show InChI InChI=1S/C37H41N5O3/c1-3-23-21-27(14-15-28(23)24-17-19-41(20-18-24)36(43)26-11-12-26)39-32-16-13-25-7-5-8-29(35(25)32)31-9-6-10-34(40-31)42-33(4-2)30(22-38-42)37(44)45/h5-10,14-15,21-22,24,26,32,39H,3-4,11-13,16-20H2,1-2H3,(H,44,45)
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NOVARTIS AG

US Patent


Assay Description
Chinese hamster ovary (CHO) cells overexpressing soluble guanylate cyclase were generated to test the effect of sGC activators in a cellular context....


US Patent US10550102 (2020)


BindingDB Entry DOI: 10.7270/Q2PC34SQ
More data for this
Ligand-Target Pair
Soluble Guanylate Cyclases


(Homo sapiens (Human))
BDBM430956
PNG
(US10550102, Example (+)-36-1)
Show SMILES CCc1cc(NC2COc3cccc(c23)-c2cccc(n2)-n2ncc(C(O)=O)c2C(F)(F)F)ccc1C1CCN(CC1)C(=O)C1CC1
Show InChI InChI=1S/C35H34F3N5O4/c1-2-20-17-23(11-12-24(20)21-13-15-42(16-14-21)33(44)22-9-10-22)40-28-19-47-29-7-3-5-25(31(28)29)27-6-4-8-30(41-27)43-32(35(36,37)38)26(18-39-43)34(45)46/h3-8,11-12,17-18,21-22,28,40H,2,9-10,13-16,19H2,1H3,(H,45,46)
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NOVARTIS AG

US Patent


Assay Description
Chinese hamster ovary (CHO) cells overexpressing soluble guanylate cyclase were generated to test the effect of sGC activators in a cellular context....


US Patent US10550102 (2020)


BindingDB Entry DOI: 10.7270/Q2PC34SQ
More data for this
Ligand-Target Pair
Soluble Guanylate Cyclases


(Homo sapiens (Human))
BDBM430957
PNG
(US10550102, Example (+)-53-3)
Show SMILES Cc1c(cnn1-c1cccc(n1)-c1cccc2CCC(Nc3c(C)cc(cc3F)C3CCN(CC3)C(=O)CC3CC3)c12)C(O)=O
Show InChI InChI=1S/C36H38FN5O3/c1-21-17-26(24-13-15-41(16-14-24)33(43)18-23-9-10-23)19-29(37)35(21)40-31-12-11-25-5-3-6-27(34(25)31)30-7-4-8-32(39-30)42-22(2)28(20-38-42)36(44)45/h3-8,17,19-20,23-24,31,40H,9-16,18H2,1-2H3,(H,44,45)
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NOVARTIS AG

US Patent


Assay Description
Chinese hamster ovary (CHO) cells overexpressing soluble guanylate cyclase were generated to test the effect of sGC activators in a cellular context....


US Patent US10550102 (2020)


BindingDB Entry DOI: 10.7270/Q2PC34SQ
More data for this
Ligand-Target Pair
Soluble Guanylate Cyclases


(Homo sapiens (Human))
BDBM430960
PNG
(US10550102, Example (+)-36-2)
Show SMILES CCc1c(cnn1-c1cccc(n1)-c1cccc2OCC(Nc3ccc(C4CCN(CC4)C(=O)C4CC4)c(CC)c3)c12)C(O)=O
Show InChI InChI=1S/C36H39N5O4/c1-3-22-19-25(13-14-26(22)23-15-17-40(18-16-23)35(42)24-11-12-24)38-30-21-45-32-9-5-7-27(34(30)32)29-8-6-10-33(39-29)41-31(4-2)28(20-37-41)36(43)44/h5-10,13-14,19-20,23-24,30,38H,3-4,11-12,15-18,21H2,1-2H3,(H,43,44)
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NOVARTIS AG

US Patent


Assay Description
Chinese hamster ovary (CHO) cells overexpressing soluble guanylate cyclase were generated to test the effect of sGC activators in a cellular context....


US Patent US10550102 (2020)


BindingDB Entry DOI: 10.7270/Q2PC34SQ
More data for this
Ligand-Target Pair
Soluble Guanylate Cyclases


(Homo sapiens (Human))
BDBM430979
PNG
(US10550102, Example 58. b). (-))
Show SMILES CCOC(=O)c1cnn(c1C)-c1cccc(n1)-c1cccc2CCC(Nc3ccc(cc3C)C3CCN(CC3)c3nnc(C)o3)c12
Show InChI InChI=1S/C36H39N7O3/c1-5-45-35(44)29-21-37-43(23(29)3)33-11-7-10-31(39-33)28-9-6-8-26-12-15-32(34(26)28)38-30-14-13-27(20-22(30)2)25-16-18-42(19-17-25)36-41-40-24(4)46-36/h6-11,13-14,20-21,25,32,38H,5,12,15-19H2,1-4H3
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NOVARTIS AG

US Patent


Assay Description
Chinese hamster ovary (CHO) cells overexpressing soluble guanylate cyclase were generated to test the effect of sGC activators in a cellular context....


US Patent US10550102 (2020)


BindingDB Entry DOI: 10.7270/Q2PC34SQ
More data for this
Ligand-Target Pair
Soluble Guanylate Cyclases


(Homo sapiens (Human))
BDBM430999
PNG
(US10550102, Example 64-2)
Show SMILES CCc1c(cnn1-c1cccc(n1)-c1cccc2CC[C@H](Oc3ccc(C4CCN(CC4)C(=O)OCC(C)C)c(CC)c3)c12)C(O)=O
Show InChI InChI=1S/C38H44N4O5/c1-5-25-21-28(14-15-29(25)26-17-19-41(20-18-26)38(45)46-23-24(3)4)47-34-16-13-27-9-7-10-30(36(27)34)32-11-8-12-35(40-32)42-33(6-2)31(22-39-42)37(43)44/h7-12,14-15,21-22,24,26,34H,5-6,13,16-20,23H2,1-4H3,(H,43,44)/t34-/m0/s1
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NOVARTIS AG

US Patent


Assay Description
Chinese hamster ovary (CHO) cells overexpressing soluble guanylate cyclase were generated to test the effect of sGC activators in a cellular context....


US Patent US10550102 (2020)


BindingDB Entry DOI: 10.7270/Q2PC34SQ
More data for this
Ligand-Target Pair
Soluble Guanylate Cyclases


(Homo sapiens (Human))
BDBM430635
PNG
(US10550102, Example (-)-1. b))
Show SMILES Cc1cc(ccc1OC1CCc2cccc(c12)-c1cccc(c1)-n1ncc(C(O)=O)c1C(F)(F)F)C1CCN(CC1)C(=O)C1CC1
Show InChI InChI=1S/C36H34F3N3O4/c1-21-18-25(22-14-16-41(17-15-22)34(43)24-8-9-24)11-12-30(21)46-31-13-10-23-4-3-7-28(32(23)31)26-5-2-6-27(19-26)42-33(36(37,38)39)29(20-40-42)35(44)45/h2-7,11-12,18-20,22,24,31H,8-10,13-17H2,1H3,(H,44,45)
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NOVARTIS AG

US Patent


Assay Description
Chinese hamster ovary (CHO) cells overexpressing soluble guanylate cyclase were generated to test the effect of sGC activators in a cellular context....


US Patent US10550102 (2020)


BindingDB Entry DOI: 10.7270/Q2PC34SQ
More data for this
Ligand-Target Pair
Soluble Guanylate Cyclases


(Homo sapiens (Human))
BDBM430740
PNG
(US10550102, Example (+)-8. b))
Show SMILES Cc1cc(ccc1NC1CCc2cccc(c12)-c1cccc(n1)-n1ncc(C(O)=O)c1C(F)(F)F)C1CCN(CC1)C(=O)C1CC1
Show InChI InChI=1S/C35H34F3N5O3/c1-20-18-24(21-14-16-42(17-15-21)33(44)23-8-9-23)11-12-27(20)40-29-13-10-22-4-2-5-25(31(22)29)28-6-3-7-30(41-28)43-32(35(36,37)38)26(19-39-43)34(45)46/h2-7,11-12,18-19,21,23,29,40H,8-10,13-17H2,1H3,(H,45,46)
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NOVARTIS AG

US Patent


Assay Description
Chinese hamster ovary (CHO) cells overexpressing soluble guanylate cyclase were generated to test the effect of sGC activators in a cellular context....


US Patent US10550102 (2020)


BindingDB Entry DOI: 10.7270/Q2PC34SQ
More data for this
Ligand-Target Pair
Soluble Guanylate Cyclases


(Homo sapiens (Human))
BDBM430865
PNG
(US10550102, Example 5-1)
Show SMILES Cc1cc2CCC(Oc3ccc4CN(Cc5ccccn5)CCc4c3)c2c(c1)-c1cccc(n1)-n1ncc(C(O)=O)c1C(F)(F)F
Show InChI InChI=1S/C35H30F3N5O3/c1-21-15-23-9-11-30(46-26-10-8-24-19-42(14-12-22(24)17-26)20-25-5-2-3-13-39-25)32(23)27(16-21)29-6-4-7-31(41-29)43-33(35(36,37)38)28(18-40-43)34(44)45/h2-8,10,13,15-18,30H,9,11-12,14,19-20H2,1H3,(H,44,45)
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NOVARTIS AG

US Patent


Assay Description
Chinese hamster ovary (CHO) cells overexpressing soluble guanylate cyclase were generated to test the effect of sGC activators in a cellular context....


US Patent US10550102 (2020)


BindingDB Entry DOI: 10.7270/Q2PC34SQ
More data for this
Ligand-Target Pair
Soluble Guanylate Cyclases


(Homo sapiens (Human))
BDBM430871
PNG
(US10550102, Example 5-4)
Show SMILES Cc1cc(ccc1O[C@H]1CCc2cccc(c12)-c1cccc(n1)-n1ncc(C(O)=O)c1C(F)(F)F)C1CCN(CC(F)(F)F)CC1
Show InChI InChI=1S/C33H30F6N4O3/c1-19-16-22(20-12-14-42(15-13-20)18-32(34,35)36)9-10-26(19)46-27-11-8-21-4-2-5-23(29(21)27)25-6-3-7-28(41-25)43-30(33(37,38)39)24(17-40-43)31(44)45/h2-7,9-10,16-17,20,27H,8,11-15,18H2,1H3,(H,44,45)/t27-/m0/s1
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NOVARTIS AG

US Patent


Assay Description
Chinese hamster ovary (CHO) cells overexpressing soluble guanylate cyclase were generated to test the effect of sGC activators in a cellular context....


US Patent US10550102 (2020)


BindingDB Entry DOI: 10.7270/Q2PC34SQ
More data for this
Ligand-Target Pair
Soluble Guanylate Cyclases


(Homo sapiens (Human))
BDBM430872
PNG
(US10550102, Example 11-3)
Show SMILES CCc1c(cnn1-c1cccc(n1)-c1cccc2CCC(Nc3ccc(cc3C)C3CCN(CC(F)(F)F)CC3)c12)C(O)=O
Show InChI InChI=1S/C34H36F3N5O2/c1-3-30-26(33(43)44)19-38-42(30)31-9-5-8-28(40-31)25-7-4-6-23-10-13-29(32(23)25)39-27-12-11-24(18-21(27)2)22-14-16-41(17-15-22)20-34(35,36)37/h4-9,11-12,18-19,22,29,39H,3,10,13-17,20H2,1-2H3,(H,43,44)
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NOVARTIS AG

US Patent


Assay Description
Chinese hamster ovary (CHO) cells overexpressing soluble guanylate cyclase were generated to test the effect of sGC activators in a cellular context....


US Patent US10550102 (2020)


BindingDB Entry DOI: 10.7270/Q2PC34SQ
More data for this
Ligand-Target Pair
Soluble Guanylate Cyclases


(Homo sapiens (Human))
BDBM430874
PNG
(US10550102, Example 11-4)
Show SMILES Cc1c(cnn1-c1cccc(c1)-c1cccc2CCC(Nc3ccc(cc3C)C3CCN(CC3)C(=O)C3CC3)c12)C(O)=O
Show InChI InChI=1S/C36H38N4O3/c1-22-19-27(24-15-17-39(18-16-24)35(41)26-9-10-26)12-13-32(22)38-33-14-11-25-5-4-8-30(34(25)33)28-6-3-7-29(20-28)40-23(2)31(21-37-40)36(42)43/h3-8,12-13,19-21,24,26,33,38H,9-11,14-18H2,1-2H3,(H,42,43)
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NOVARTIS AG

US Patent


Assay Description
Chinese hamster ovary (CHO) cells overexpressing soluble guanylate cyclase were generated to test the effect of sGC activators in a cellular context....


US Patent US10550102 (2020)


BindingDB Entry DOI: 10.7270/Q2PC34SQ
More data for this
Ligand-Target Pair
Soluble Guanylate Cyclases


(Homo sapiens (Human))
BDBM430876
PNG
(Example 12-A. tert-Butyl 4-(4-((7-(6-(4-(ethoxycar...)
Show SMILES CCOC(=O)c1cnn(c1C(F)(F)F)-c1cccc(n1)-c1cccc2CCN(Cc3ccc(cc3)C3CCN(CC3)C(=O)OC(C)(C)C)c12
Show InChI InChI=1S/C37H40F3N5O4/c1-5-48-34(46)29-22-41-45(33(29)37(38,39)40)31-11-7-10-30(42-31)28-9-6-8-27-18-21-44(32(27)28)23-24-12-14-25(15-13-24)26-16-19-43(20-17-26)35(47)49-36(2,3)4/h6-15,22,26H,5,16-21,23H2,1-4H3
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NOVARTIS AG

US Patent


Assay Description
Chinese hamster ovary (CHO) cells overexpressing soluble guanylate cyclase were generated to test the effect of sGC activators in a cellular context....


US Patent US10550102 (2020)


BindingDB Entry DOI: 10.7270/Q2PC34SQ
More data for this
Ligand-Target Pair
Soluble Guanylate Cyclases


(Homo sapiens (Human))
BDBM430891
PNG
(US10550102, Example 17b)
Show SMILES CCOC(=O)c1cnn(c1CC)-c1cccc(n1)-c1cccc2c(C)c[nH]c12
Show InChI InChI=1S/C22H22N4O2/c1-4-19-17(22(27)28-5-2)13-24-26(19)20-11-7-10-18(25-20)16-9-6-8-15-14(3)12-23-21(15)16/h6-13,23H,4-5H2,1-3H3
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NOVARTIS AG

US Patent


Assay Description
Chinese hamster ovary (CHO) cells overexpressing soluble guanylate cyclase were generated to test the effect of sGC activators in a cellular context....


US Patent US10550102 (2020)


BindingDB Entry DOI: 10.7270/Q2PC34SQ
More data for this
Ligand-Target Pair
Soluble Guanylate Cyclases


(Homo sapiens (Human))
BDBM430906
PNG
(US10550102, Example (+)-46-5)
Show SMILES Cc1c(cnn1-c1cccc(n1)-c1cccc2CCC(Nc3cc(F)c(cc3C)C3CCN(CC3)C(=O)CC3CC3)c12)C(O)=O
Show InChI InChI=1S/C36H38FN5O3/c1-21-17-27(24-13-15-41(16-14-24)34(43)18-23-9-10-23)29(37)19-32(21)39-31-12-11-25-5-3-6-26(35(25)31)30-7-4-8-33(40-30)42-22(2)28(20-38-42)36(44)45/h3-8,17,19-20,23-24,31,39H,9-16,18H2,1-2H3,(H,44,45)
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NOVARTIS AG

US Patent


Assay Description
Chinese hamster ovary (CHO) cells overexpressing soluble guanylate cyclase were generated to test the effect of sGC activators in a cellular context....


US Patent US10550102 (2020)


BindingDB Entry DOI: 10.7270/Q2PC34SQ
More data for this
Ligand-Target Pair
Soluble Guanylate Cyclases


(Homo sapiens (Human))
BDBM430908
PNG
(US10550102, Example (-)-46-5)
Show SMILES Cc1c(cnn1-c1cccc(n1)-c1cccc2CCC(Nc3cc(F)c(cc3C)C3CCN(CC3)C(=O)CC3CC3)c12)C(O)=O
Show InChI InChI=1S/C36H38FN5O3/c1-21-17-27(24-13-15-41(16-14-24)34(43)18-23-9-10-23)29(37)19-32(21)39-31-12-11-25-5-3-6-26(35(25)31)30-7-4-8-33(40-30)42-22(2)28(20-38-42)36(44)45/h3-8,17,19-20,23-24,31,39H,9-16,18H2,1-2H3,(H,44,45)
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NOVARTIS AG

US Patent


Assay Description
Chinese hamster ovary (CHO) cells overexpressing soluble guanylate cyclase were generated to test the effect of sGC activators in a cellular context....


US Patent US10550102 (2020)


BindingDB Entry DOI: 10.7270/Q2PC34SQ
More data for this
Ligand-Target Pair
Soluble Guanylate Cyclases


(Homo sapiens (Human))
BDBM430911
PNG
(US10550102, Example 21-1 | US10550102, Example 21-...)
Show SMILES CCc1c(cnn1-c1cccc(n1)-c1cccc2CCN(Cc3ccc(cc3C)C3CCN(CC3)C(=O)C3CC3)c12)C(O)=O
Show InChI InChI=1S/C36H39N5O3/c1-3-32-30(36(43)44)21-37-41(32)33-9-5-8-31(38-33)29-7-4-6-25-16-19-40(34(25)29)22-28-13-12-27(20-23(28)2)24-14-17-39(18-15-24)35(42)26-10-11-26/h4-9,12-13,20-21,24,26H,3,10-11,14-19,22H2,1-2H3,(H,43,44)
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NOVARTIS AG

US Patent


Assay Description
Chinese hamster ovary (CHO) cells overexpressing soluble guanylate cyclase were generated to test the effect of sGC activators in a cellular context....


US Patent US10550102 (2020)


BindingDB Entry DOI: 10.7270/Q2PC34SQ
More data for this
Ligand-Target Pair
Soluble Guanylate Cyclases


(Homo sapiens (Human))
BDBM430921
PNG
(Example 24-A. Ethyl 5-methyl-1-(6-(1-(2-methyl-4-(...)
Show SMILES CCOC(=O)c1cnn(c1C)-c1cccc(n1)-c1cccc2CCN(Cc3ccc(cc3C)C3CCNCC3)c12
Show InChI InChI=1S/C33H37N5O2/c1-4-40-33(39)29-20-35-38(23(29)3)31-10-6-9-30(36-31)28-8-5-7-25-15-18-37(32(25)28)21-27-12-11-26(19-22(27)2)24-13-16-34-17-14-24/h5-12,19-20,24,34H,4,13-18,21H2,1-3H3
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NOVARTIS AG

US Patent


Assay Description
Chinese hamster ovary (CHO) cells overexpressing soluble guanylate cyclase were generated to test the effect of sGC activators in a cellular context....


US Patent US10550102 (2020)


BindingDB Entry DOI: 10.7270/Q2PC34SQ
More data for this
Ligand-Target Pair
Soluble Guanylate Cyclases


(Homo sapiens (Human))
BDBM430928
PNG
(US10550102, Example 51a)
Show SMILES CCc1c(cnn1-c1cccc(n1)-c1cccc2CCC(Nc3ccc(C4CCN(CC4)C(=O)OC(C)C)c(CC)c3)c12)C(O)=O
Show InChI InChI=1S/C37H43N5O4/c1-5-24-21-27(14-15-28(24)25-17-19-41(20-18-25)37(45)46-23(3)4)39-32-16-13-26-9-7-10-29(35(26)32)31-11-8-12-34(40-31)42-33(6-2)30(22-38-42)36(43)44/h7-12,14-15,21-23,25,32,39H,5-6,13,16-20H2,1-4H3,(H,43,44)
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NOVARTIS AG

US Patent


Assay Description
Chinese hamster ovary (CHO) cells overexpressing soluble guanylate cyclase were generated to test the effect of sGC activators in a cellular context....


US Patent US10550102 (2020)


BindingDB Entry DOI: 10.7270/Q2PC34SQ
More data for this
Ligand-Target Pair
Soluble Guanylate Cyclases


(Homo sapiens (Human))
BDBM430931
PNG
(Example 29-A. (S)-tert-Butyl 4-(4-((7-(4-(4-(ethox...)
Show SMILES CCOC(=O)N1CCC(CC1)c1ccc(O[C@H]2CCc3cccc(c23)-c2cccc(n2)-n2ncc(C(O)=O)c2CC)cc1CC
Show InChI InChI=1S/C36H40N4O5/c1-4-23-21-26(14-15-27(23)24-17-19-39(20-18-24)36(43)44-6-3)45-32-16-13-25-9-7-10-28(34(25)32)30-11-8-12-33(38-30)40-31(5-2)29(22-37-40)35(41)42/h7-12,14-15,21-22,24,32H,4-6,13,16-20H2,1-3H3,(H,41,42)/t32-/m0/s1
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NOVARTIS AG

US Patent


Assay Description
Chinese hamster ovary (CHO) cells overexpressing soluble guanylate cyclase were generated to test the effect of sGC activators in a cellular context....


US Patent US10550102 (2020)


BindingDB Entry DOI: 10.7270/Q2PC34SQ
More data for this
Ligand-Target Pair
Soluble Guanylate Cyclases


(Homo sapiens (Human))
BDBM430933
PNG
(Example 30-A. Ethyl 5-ethyl-6-((S)-3-(3-ethyl-4-(1...)
Show SMILES CCc1c(cnn1-c1cccc(n1)-c1cccc2CC[C@H](Oc3ccc(C4CCN(CC4)C(=O)[C@H](C)O)c(CC)c3)c12)C(O)=O
Show InChI InChI=1S/C36H40N4O5/c1-4-23-20-26(13-14-27(23)24-16-18-39(19-17-24)35(42)22(3)41)45-32-15-12-25-8-6-9-28(34(25)32)30-10-7-11-33(38-30)40-31(5-2)29(21-37-40)36(43)44/h6-11,13-14,20-22,24,32,41H,4-5,12,15-19H2,1-3H3,(H,43,44)/t22-,32-/m0/s1
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NOVARTIS AG

US Patent


Assay Description
Chinese hamster ovary (CHO) cells overexpressing soluble guanylate cyclase were generated to test the effect of sGC activators in a cellular context....


US Patent US10550102 (2020)


BindingDB Entry DOI: 10.7270/Q2PC34SQ
More data for this
Ligand-Target Pair
Soluble Guanylate Cyclases


(Homo sapiens (Human))
BDBM430934
PNG
(US10550102, Example (+)-52-1)
Show SMILES CCOC(=O)N1CCC(CC1)c1ccc(NC2CCc3cccc(c23)-c2cccc(n2)-n2ncc(C(O)=O)c2CC)cc1CC
Show InChI InChI=1S/C36H41N5O4/c1-4-23-21-26(14-15-27(23)24-17-19-40(20-18-24)36(44)45-6-3)38-31-16-13-25-9-7-10-28(34(25)31)30-11-8-12-33(39-30)41-32(5-2)29(22-37-41)35(42)43/h7-12,14-15,21-22,24,31,38H,4-6,13,16-20H2,1-3H3,(H,42,43)
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NOVARTIS AG

US Patent


Assay Description
Chinese hamster ovary (CHO) cells overexpressing soluble guanylate cyclase were generated to test the effect of sGC activators in a cellular context....


US Patent US10550102 (2020)


BindingDB Entry DOI: 10.7270/Q2PC34SQ
More data for this
Ligand-Target Pair
Soluble Guanylate Cyclases


(Homo sapiens (Human))
BDBM430940
PNG
(US10550102, Example (-)-52-3)
Show SMILES CCc1c(cnn1-c1cccc(n1)-c1cccc2CCC(Nc3ccc(C4CCN(CC4)C(=O)OCC=C)c(CC)c3)c12)C(O)=O
Show InChI InChI=1S/C37H41N5O4/c1-4-21-46-37(45)41-19-17-25(18-20-41)28-15-14-27(22-24(28)5-2)39-32-16-13-26-9-7-10-29(35(26)32)31-11-8-12-34(40-31)42-33(6-3)30(23-38-42)36(43)44/h4,7-12,14-15,22-23,25,32,39H,1,5-6,13,16-21H2,2-3H3,(H,43,44)
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NOVARTIS AG

US Patent


Assay Description
Chinese hamster ovary (CHO) cells overexpressing soluble guanylate cyclase were generated to test the effect of sGC activators in a cellular context....


US Patent US10550102 (2020)


BindingDB Entry DOI: 10.7270/Q2PC34SQ
More data for this
Ligand-Target Pair
Soluble Guanylate Cyclases


(Homo sapiens (Human))
BDBM430941
PNG
(US10550102, Example 31-4)
Show SMILES CCc1c(cnn1-c1cccc(n1)-c1cccc2CC[C@H](Oc3ccc(C4CCN(CC4)C(=O)C4(O)CCC4)c(CC)c3)c12)C(O)=O
Show InChI InChI=1S/C38H42N4O5/c1-3-24-22-27(13-14-28(24)25-16-20-41(21-17-25)37(45)38(46)18-7-19-38)47-33-15-12-26-8-5-9-29(35(26)33)31-10-6-11-34(40-31)42-32(4-2)30(23-39-42)36(43)44/h5-6,8-11,13-14,22-23,25,33,46H,3-4,7,12,15-21H2,1-2H3,(H,43,44)/t33-/m0/s1
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n/an/an/an/a 0.5n/an/an/an/a



NOVARTIS AG

US Patent


Assay Description
Chinese hamster ovary (CHO) cells overexpressing soluble guanylate cyclase were generated to test the effect of sGC activators in a cellular context....


US Patent US10550102 (2020)


BindingDB Entry DOI: 10.7270/Q2PC34SQ
More data for this
Ligand-Target Pair
Soluble Guanylate Cyclases


(Homo sapiens (Human))
BDBM430949
PNG
(US10550102, Example 34a)
Show SMILES Cc1c(cnn1-c1cccc(n1)-c1cccc2OCC(Nc3ccc(cc3C)C3CCN(CC3)C(=O)C3CC3)c12)C(O)=O
Show InChI InChI=1S/C34H35N5O4/c1-20-17-24(22-13-15-38(16-14-22)33(40)23-9-10-23)11-12-27(20)36-29-19-43-30-7-3-5-25(32(29)30)28-6-4-8-31(37-28)39-21(2)26(18-35-39)34(41)42/h3-8,11-12,17-18,22-23,29,36H,9-10,13-16,19H2,1-2H3,(H,41,42)
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n/an/an/an/a 0.5n/an/an/an/a



NOVARTIS AG

US Patent


Assay Description
Chinese hamster ovary (CHO) cells overexpressing soluble guanylate cyclase were generated to test the effect of sGC activators in a cellular context....


US Patent US10550102 (2020)


BindingDB Entry DOI: 10.7270/Q2PC34SQ
More data for this
Ligand-Target Pair
Soluble Guanylate Cyclases


(Homo sapiens (Human))
BDBM430968
PNG
(US10550102, Example 38-1 (-))
Show SMILES CCc1c(cnn1-c1cccc(n1)-c1cccc2CCC(Cc3ccc(C4CCN(CC4)C(=O)C4CC4)c(CC)c3)c12)C(O)=O
Show InChI InChI=1S/C38H42N4O3/c1-3-25-21-24(11-16-30(25)26-17-19-41(20-18-26)37(43)28-13-14-28)22-29-15-12-27-7-5-8-31(36(27)29)33-9-6-10-35(40-33)42-34(4-2)32(23-39-42)38(44)45/h5-11,16,21,23,26,28-29H,3-4,12-15,17-20,22H2,1-2H3,(H,44,45)
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n/an/an/an/a 17n/an/an/an/a



NOVARTIS AG

US Patent


Assay Description
Chinese hamster ovary (CHO) cells overexpressing soluble guanylate cyclase were generated to test the effect of sGC activators in a cellular context....


US Patent US10550102 (2020)


BindingDB Entry DOI: 10.7270/Q2PC34SQ
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%