BindingDB logo
myBDB logout

Patent code US10550127

Compile Data Set for Download or QSAR
Found 20 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Free fatty acid receptor 1


(Homo sapiens (Human))
BDBM431933
PNG
(((S)-6-{(R)-4-[2,6-Dimethyl-4-(1-methyl-6-oxo-1,6-...)
Show SMILES Cc1cc(cc(C)c1-c1ccc(F)c2[C@@H](CCc12)Nc1cc2OC[C@@H](CC(O)=O)c2cn1)-c1ccc(=O)n(C)c1
Show InChI InChI=1S/C32H30FN3O4/c1-17-10-20(19-4-9-29(37)36(3)15-19)11-18(2)31(17)22-5-7-25(33)32-23(22)6-8-26(32)35-28-13-27-24(14-34-28)21(16-40-27)12-30(38)39/h4-5,7,9-11,13-15,21,26H,6,8,12,16H2,1-3H3,(H,34,35)(H,38,39)/t21-,26-/m1/s1
PDB

Reactome pathway

UniProtKB/SwissProt

antibodypedia
GoogleScholar
UniChem
US Patent
n/an/an/an/a 27n/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
IP1 accumulation measurements using the IPOne assay systemó1321N1 cells stably expressing human GPR40 receptor (Euroscreen, Belgium) are seeded 24 h ...


US Patent US10550127 (2020)


BindingDB Entry DOI: 10.7270/Q2WW7M33
More data for this
Ligand-Target Pair
Free fatty acid receptor 1


(Homo sapiens (Human))
BDBM431930
PNG
(((S)-6-{(R)-4-[2,6-Dimethyl-4-(1-methyl-2-oxo-1,2-...)
Show SMILES Cc1cc(cc(C)c1-c1ccc(F)c2[C@@H](CCc12)Nc1cc2OC[C@@H](CC(O)=O)c2cn1)-c1ccn(C)c(=O)n1
Show InChI InChI=1S/C31H29FN4O4/c1-16-10-18(24-8-9-36(3)31(39)35-24)11-17(2)29(16)20-4-6-23(32)30-21(20)5-7-25(30)34-27-13-26-22(14-33-27)19(15-40-26)12-28(37)38/h4,6,8-11,13-14,19,25H,5,7,12,15H2,1-3H3,(H,33,34)(H,37,38)/t19-,25-/m1/s1
PDB

Reactome pathway

UniProtKB/SwissProt

antibodypedia
GoogleScholar
UniChem
US Patent
n/an/an/an/a 27n/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
IP1 accumulation measurements using the IPOne assay systemó1321N1 cells stably expressing human GPR40 receptor (Euroscreen, Belgium) are seeded 24 h ...


US Patent US10550127 (2020)


BindingDB Entry DOI: 10.7270/Q2WW7M33
More data for this
Ligand-Target Pair
Free fatty acid receptor 1


(Homo sapiens (Human))
BDBM431928
PNG
(((S)-6-{(R)-4-[2,6-Dimethyl-4-(tetrahydro-furan-3-...)
Show SMILES Cc1cc(OCC2CCOC2)cc(C)c1-c1ccc(F)c2[C@@H](CCc12)Nc1cc2OC[C@@H](CC(O)=O)c2cn1
Show InChI InChI=1S/C31H33FN2O5/c1-17-9-21(38-15-19-7-8-37-14-19)10-18(2)30(17)22-3-5-25(32)31-23(22)4-6-26(31)34-28-12-27-24(13-33-28)20(16-39-27)11-29(35)36/h3,5,9-10,12-13,19-20,26H,4,6-8,11,14-16H2,1-2H3,(H,33,34)(H,35,36)/t19?,20-,26-/m1/s1
PDB

Reactome pathway

UniProtKB/SwissProt

antibodypedia
GoogleScholar
UniChem
US Patent
n/an/an/an/a 27n/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
IP1 accumulation measurements using the IPOne assay systemó1321N1 cells stably expressing human GPR40 receptor (Euroscreen, Belgium) are seeded 24 h ...


US Patent US10550127 (2020)


BindingDB Entry DOI: 10.7270/Q2WW7M33
More data for this
Ligand-Target Pair
Free fatty acid receptor 1


(Homo sapiens (Human))
BDBM431916
PNG
(((R)-6-{(R)-7-Fluoro-4-[4-(3-hydroxy-3-methyl-buto...)
Show SMILES Cc1cc(OCCC(C)(C)O)cc(C)c1-c1ccc(F)c2[C@@H](CCc12)Nc1cc2OC[C@H](CC(O)=O)c2cn1
Show InChI InChI=1S/C31H35FN2O5/c1-17-11-20(38-10-9-31(3,4)37)12-18(2)29(17)21-5-7-24(32)30-22(21)6-8-25(30)34-27-14-26-23(15-33-27)19(16-39-26)13-28(35)36/h5,7,11-12,14-15,19,25,37H,6,8-10,13,16H2,1-4H3,(H,33,34)(H,35,36)/t19-,25+/m0/s1
PDB

Reactome pathway

UniProtKB/SwissProt

antibodypedia
GoogleScholar
UniChem
US Patent
n/an/an/an/a 764n/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
IP1 accumulation measurements using the IPOne assay systemó1321N1 cells stably expressing human GPR40 receptor (Euroscreen, Belgium) are seeded 24 h ...


US Patent US10550127 (2020)


BindingDB Entry DOI: 10.7270/Q2WW7M33
More data for this
Ligand-Target Pair
Free fatty acid receptor 1


(Homo sapiens (Human))
BDBM431920
PNG
(((R)-6-{(R)-4-[2,6-Dimethyl-4-(2-methyl-2H-tetrazo...)
Show SMILES Cc1cc(cc(C)c1-c1ccc(F)c2[C@@H](CCc12)Nc1cc2OC[C@H](CC(O)=O)c2cn1)-c1nnn(C)n1
Show InChI InChI=1S/C28H27FN6O3/c1-14-8-16(28-32-34-35(3)33-28)9-15(2)26(14)18-4-6-21(29)27-19(18)5-7-22(27)31-24-11-23-20(12-30-24)17(13-38-23)10-25(36)37/h4,6,8-9,11-12,17,22H,5,7,10,13H2,1-3H3,(H,30,31)(H,36,37)/t17-,22+/m0/s1
PDB

Reactome pathway

UniProtKB/SwissProt

antibodypedia
GoogleScholar
UniChem
US Patent
n/an/an/an/a 382n/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
IP1 accumulation measurements using the IPOne assay systemó1321N1 cells stably expressing human GPR40 receptor (Euroscreen, Belgium) are seeded 24 h ...


US Patent US10550127 (2020)


BindingDB Entry DOI: 10.7270/Q2WW7M33
More data for this
Ligand-Target Pair
Free fatty acid receptor 1


(Homo sapiens (Human))
BDBM431923
PNG
(US10550127, Example 9 | [(S)-6-((R)-4-{2,6-Dimethy...)
Show SMILES Cc1cc(O[C@@H]2CCOC2)cc(C)c1-c1ccc(F)c2[C@@H](CCc12)Nc1cc2OC[C@@H](CC(O)=O)c2cn1
Show InChI InChI=1S/C30H31FN2O5/c1-16-9-20(38-19-7-8-36-15-19)10-17(2)29(16)21-3-5-24(31)30-22(21)4-6-25(30)33-27-12-26-23(13-32-27)18(14-37-26)11-28(34)35/h3,5,9-10,12-13,18-19,25H,4,6-8,11,14-15H2,1-2H3,(H,32,33)(H,34,35)/t18-,19-,25-/m1/s1
PDB

Reactome pathway

UniProtKB/SwissProt

antibodypedia
GoogleScholar
UniChem
US Patent
n/an/an/an/a 57n/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
IP1 accumulation measurements using the IPOne assay systemó1321N1 cells stably expressing human GPR40 receptor (Euroscreen, Belgium) are seeded 24 h ...


US Patent US10550127 (2020)


BindingDB Entry DOI: 10.7270/Q2WW7M33
More data for this
Ligand-Target Pair
Free fatty acid receptor 1


(Homo sapiens (Human))
BDBM431924
PNG
(((S)-6-{(R)-4-[2,6-Dimethyl-4-(tetrahydro-pyran-4-...)
Show SMILES Cc1cc(OC2CCOCC2)cc(C)c1-c1ccc(F)c2[C@@H](CCc12)Nc1cc2OC[C@@H](CC(O)=O)c2cn1
Show InChI InChI=1S/C31H33FN2O5/c1-17-11-21(39-20-7-9-37-10-8-20)12-18(2)30(17)22-3-5-25(32)31-23(22)4-6-26(31)34-28-14-27-24(15-33-28)19(16-38-27)13-29(35)36/h3,5,11-12,14-15,19-20,26H,4,6-10,13,16H2,1-2H3,(H,33,34)(H,35,36)/t19-,26-/m1/s1
PDB

Reactome pathway

UniProtKB/SwissProt

antibodypedia
GoogleScholar
UniChem
US Patent
n/an/an/an/a 56n/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
IP1 accumulation measurements using the IPOne assay systemó1321N1 cells stably expressing human GPR40 receptor (Euroscreen, Belgium) are seeded 24 h ...


US Patent US10550127 (2020)


BindingDB Entry DOI: 10.7270/Q2WW7M33
More data for this
Ligand-Target Pair
Free fatty acid receptor 1


(Homo sapiens (Human))
BDBM431915
PNG
(((S)-6-{(R)-7-Fluoro-4-[4-(3-hydroxy-3-methyl-buto...)
Show SMILES Cc1cc(OCCC(C)(C)O)cc(C)c1-c1ccc(F)c2[C@@H](CCc12)Nc1cc2OC[C@@H](CC(O)=O)c2cn1
Show InChI InChI=1S/C31H35FN2O5/c1-17-11-20(38-10-9-31(3,4)37)12-18(2)29(17)21-5-7-24(32)30-22(21)6-8-25(30)34-27-14-26-23(15-33-27)19(16-39-26)13-28(35)36/h5,7,11-12,14-15,19,25,37H,6,8-10,13,16H2,1-4H3,(H,33,34)(H,35,36)/t19-,25-/m1/s1
PDB

Reactome pathway

UniProtKB/SwissProt

antibodypedia
GoogleScholar
UniChem
US Patent
n/an/an/an/a 15n/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
IP1 accumulation measurements using the IPOne assay systemó1321N1 cells stably expressing human GPR40 receptor (Euroscreen, Belgium) are seeded 24 h ...


US Patent US10550127 (2020)


BindingDB Entry DOI: 10.7270/Q2WW7M33
More data for this
Ligand-Target Pair
Free fatty acid receptor 1


(Homo sapiens (Human))
BDBM431917
PNG
(((S)-6-{(R)-4-[4-(3-Hydroxy-3-methyl-butoxy)-2,6-d...)
Show SMILES Cc1cc(OCCC(C)(C)O)cc(C)c1-c1cccc2[C@@H](CCc12)Nc1cc2OC[C@@H](CC(O)=O)c2cn1
Show InChI InChI=1S/C31H36N2O5/c1-18-12-21(37-11-10-31(3,4)36)13-19(2)30(18)24-7-5-6-23-22(24)8-9-26(23)33-28-15-27-25(16-32-28)20(17-38-27)14-29(34)35/h5-7,12-13,15-16,20,26,36H,8-11,14,17H2,1-4H3,(H,32,33)(H,34,35)/t20-,26-/m1/s1
PDB

Reactome pathway

UniProtKB/SwissProt

antibodypedia
GoogleScholar
UniChem
US Patent
n/an/an/an/a 21n/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
IP1 accumulation measurements using the IPOne assay systemó1321N1 cells stably expressing human GPR40 receptor (Euroscreen, Belgium) are seeded 24 h ...


US Patent US10550127 (2020)


BindingDB Entry DOI: 10.7270/Q2WW7M33
More data for this
Ligand-Target Pair
Free fatty acid receptor 1


(Homo sapiens (Human))
BDBM431927
PNG
(((S)-6-{(R)-7-Fluoro-4-[4-(2-hydroxo-2-methyl-prop...)
Show SMILES Cc1cc(OCC(C)(C)O)cc(C)c1-c1ccc(F)c2[C@@H](CCc12)Nc1cc2OC[C@@H](CC(O)=O)c2cn1
Show InChI InChI=1S/C30H33FN2O5/c1-16-9-19(38-15-30(3,4)36)10-17(2)28(16)20-5-7-23(31)29-21(20)6-8-24(29)33-26-12-25-22(13-32-26)18(14-37-25)11-27(34)35/h5,7,9-10,12-13,18,24,36H,6,8,11,14-15H2,1-4H3,(H,32,33)(H,34,35)/t18-,24-/m1/s1
PDB

Reactome pathway

UniProtKB/SwissProt

antibodypedia
GoogleScholar
UniChem
US Patent
n/an/an/an/a 35n/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
IP1 accumulation measurements using the IPOne assay systemó1321N1 cells stably expressing human GPR40 receptor (Euroscreen, Belgium) are seeded 24 h ...


US Patent US10550127 (2020)


BindingDB Entry DOI: 10.7270/Q2WW7M33
More data for this
Ligand-Target Pair
Free fatty acid receptor 1


(Homo sapiens (Human))
BDBM431918
PNG
(((R)-6-{(R)-4-[4-(3-Hydroxy-3-methyl-butoxy)-2,6-d...)
Show SMILES Cc1cc(OCCC(C)(C)O)cc(C)c1-c1cccc2[C@@H](CCc12)Nc1cc2OC[C@H](CC(O)=O)c2cn1
Show InChI InChI=1S/C31H36N2O5/c1-18-12-21(37-11-10-31(3,4)36)13-19(2)30(18)24-7-5-6-23-22(24)8-9-26(23)33-28-15-27-25(16-32-28)20(17-38-27)14-29(34)35/h5-7,12-13,15-16,20,26,36H,8-11,14,17H2,1-4H3,(H,32,33)(H,34,35)/t20-,26+/m0/s1
PDB

Reactome pathway

UniProtKB/SwissProt

antibodypedia
GoogleScholar
UniChem
US Patent
n/an/an/an/a 751n/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
IP1 accumulation measurements using the IPOne assay systemó1321N1 cells stably expressing human GPR40 receptor (Euroscreen, Belgium) are seeded 24 h ...


US Patent US10550127 (2020)


BindingDB Entry DOI: 10.7270/Q2WW7M33
More data for this
Ligand-Target Pair
Free fatty acid receptor 1


(Homo sapiens (Human))
BDBM431919
PNG
(((S)-6-{(R)-4-[2,6-Dimethyl-4-(2-methyl-2H-tetrazo...)
Show SMILES Cc1cc(cc(C)c1-c1ccc(F)c2[C@@H](CCc12)Nc1cc2OC[C@@H](CC(O)=O)c2cn1)-c1nnn(C)n1
Show InChI InChI=1S/C28H27FN6O3/c1-14-8-16(28-32-34-35(3)33-28)9-15(2)26(14)18-4-6-21(29)27-19(18)5-7-22(27)31-24-11-23-20(12-30-24)17(13-38-23)10-25(36)37/h4,6,8-9,11-12,17,22H,5,7,10,13H2,1-3H3,(H,30,31)(H,36,37)/t17-,22-/m1/s1
PDB

Reactome pathway

UniProtKB/SwissProt

antibodypedia
GoogleScholar
UniChem
US Patent
n/an/an/an/a 6n/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
IP1 accumulation measurements using the IPOne assay systemó1321N1 cells stably expressing human GPR40 receptor (Euroscreen, Belgium) are seeded 24 h ...


US Patent US10550127 (2020)


BindingDB Entry DOI: 10.7270/Q2WW7M33
More data for this
Ligand-Target Pair
Free fatty acid receptor 1


(Homo sapiens (Human))
BDBM431921
PNG
(((S)-6-{(R)-4-[2,6-Dimethyl-4-(2-methyl-2H-tetrazo...)
Show SMILES Cc1cc(cc(C)c1-c1cccc2[C@@H](CCc12)Nc1cc2OC[C@@H](CC(O)=O)c2cn1)-c1nnn(C)n1
Show InChI InChI=1S/C28H28N6O3/c1-15-9-17(28-31-33-34(3)32-28)10-16(2)27(15)21-6-4-5-20-19(21)7-8-23(20)30-25-12-24-22(13-29-25)18(14-37-24)11-26(35)36/h4-6,9-10,12-13,18,23H,7-8,11,14H2,1-3H3,(H,29,30)(H,35,36)/t18-,23-/m1/s1
PDB

Reactome pathway

UniProtKB/SwissProt

antibodypedia
GoogleScholar
UniChem
US Patent
n/an/an/an/a 7n/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
IP1 accumulation measurements using the IPOne assay systemó1321N1 cells stably expressing human GPR40 receptor (Euroscreen, Belgium) are seeded 24 h ...


US Patent US10550127 (2020)


BindingDB Entry DOI: 10.7270/Q2WW7M33
More data for this
Ligand-Target Pair
Free fatty acid receptor 1


(Homo sapiens (Human))
BDBM431931
PNG
(((S)-6-{(R)-4-[2,6-Dimethyl-4-(1-methyl-2-oxo-1,2-...)
Show SMILES Cc1cc(cc(C)c1-c1ccc(F)c2[C@@H](CCc12)Nc1cc2OC[C@@H](CC(O)=O)c2cn1)-c1ccn(C)c(=O)c1
Show InChI InChI=1S/C32H30FN3O4/c1-17-10-20(19-8-9-36(3)29(37)12-19)11-18(2)31(17)22-4-6-25(33)32-23(22)5-7-26(32)35-28-14-27-24(15-34-28)21(16-40-27)13-30(38)39/h4,6,8-12,14-15,21,26H,5,7,13,16H2,1-3H3,(H,34,35)(H,38,39)/t21-,26-/m1/s1
PDB

Reactome pathway

UniProtKB/SwissProt

antibodypedia
GoogleScholar
UniChem
US Patent
n/an/an/an/a 12n/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
IP1 accumulation measurements using the IPOne assay systemó1321N1 cells stably expressing human GPR40 receptor (Euroscreen, Belgium) are seeded 24 h ...


US Patent US10550127 (2020)


BindingDB Entry DOI: 10.7270/Q2WW7M33
More data for this
Ligand-Target Pair
Free fatty acid receptor 1


(Homo sapiens (Human))
BDBM431929
PNG
(US10550127, Example 15 | [(S)-6-((R)-7-Fluoro-4-{4...)
Show SMILES Cc1cc(cc(C)c1-c1ccc(F)c2[C@@H](CCc12)Nc1cc2OC[C@@H](CC(O)=O)c2cn1)-c1nnn(CC(C)(C)O)n1
Show InChI InChI=1S/C31H33FN6O4/c1-16-9-18(30-35-37-38(36-30)15-31(3,4)41)10-17(2)28(16)20-5-7-23(32)29-21(20)6-8-24(29)34-26-12-25-22(13-33-26)19(14-42-25)11-27(39)40/h5,7,9-10,12-13,19,24,41H,6,8,11,14-15H2,1-4H3,(H,33,34)(H,39,40)/t19-,24-/m1/s1
PDB

Reactome pathway

UniProtKB/SwissProt

antibodypedia
GoogleScholar
UniChem
US Patent
n/an/an/an/a 9n/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
IP1 accumulation measurements using the IPOne assay systemó1321N1 cells stably expressing human GPR40 receptor (Euroscreen, Belgium) are seeded 24 h ...


US Patent US10550127 (2020)


BindingDB Entry DOI: 10.7270/Q2WW7M33
More data for this
Ligand-Target Pair
Free fatty acid receptor 1


(Homo sapiens (Human))
BDBM431932
PNG
(((S)-6-{(R)-4-[2,6-Dimethyl-4-(1-methyl-6-oxo-1,6-...)
Show SMILES Cc1cc(cc(C)c1-c1ccc(F)c2[C@@H](CCc12)Nc1cc2OC[C@@H](CC(O)=O)c2cn1)-c1cc(=O)n(C)cn1
Show InChI InChI=1S/C31H29FN4O4/c1-16-8-18(25-11-28(37)36(3)15-34-25)9-17(2)30(16)20-4-6-23(32)31-21(20)5-7-24(31)35-27-12-26-22(13-33-27)19(14-40-26)10-29(38)39/h4,6,8-9,11-13,15,19,24H,5,7,10,14H2,1-3H3,(H,33,35)(H,38,39)/t19-,24-/m1/s1
PDB

Reactome pathway

UniProtKB/SwissProt

antibodypedia
GoogleScholar
UniChem
US Patent
n/an/an/an/a 14n/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
IP1 accumulation measurements using the IPOne assay systemó1321N1 cells stably expressing human GPR40 receptor (Euroscreen, Belgium) are seeded 24 h ...


US Patent US10550127 (2020)


BindingDB Entry DOI: 10.7270/Q2WW7M33
More data for this
Ligand-Target Pair
Free fatty acid receptor 1


(Homo sapiens (Human))
BDBM431934
PNG
(US10550127, Example 20 | {(S)-6-[(R)-4-(2,6-Dimeth...)
Show SMILES Cc1cc(cc(C)c1-c1ccc(F)c2[C@@H](CCc12)Nc1cc2OC[C@@H](CC(O)=O)c2cn1)-c1cnccn1
Show InChI InChI=1S/C30H27FN4O3/c1-16-9-18(25-14-32-7-8-33-25)10-17(2)29(16)20-3-5-23(31)30-21(20)4-6-24(30)35-27-12-26-22(13-34-27)19(15-38-26)11-28(36)37/h3,5,7-10,12-14,19,24H,4,6,11,15H2,1-2H3,(H,34,35)(H,36,37)/t19-,24-/m1/s1
PDB

Reactome pathway

UniProtKB/SwissProt

antibodypedia
GoogleScholar
UniChem
US Patent
n/an/an/an/a 9n/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
IP1 accumulation measurements using the IPOne assay systemó1321N1 cells stably expressing human GPR40 receptor (Euroscreen, Belgium) are seeded 24 h ...


US Patent US10550127 (2020)


BindingDB Entry DOI: 10.7270/Q2WW7M33
More data for this
Ligand-Target Pair
Free fatty acid receptor 1


(Homo sapiens (Human))
BDBM431922
PNG
(((R)-6-{(R)-4-[2,6-Dimethyl-4-(2-methyl-2H-tetrazo...)
Show SMILES Cc1cc(cc(C)c1-c1cccc2[C@@H](CCc12)Nc1cc2OC[C@H](CC(O)=O)c2cn1)-c1nnn(C)n1
Show InChI InChI=1S/C28H28N6O3/c1-15-9-17(28-31-33-34(3)32-28)10-16(2)27(15)21-6-4-5-20-19(21)7-8-23(20)30-25-12-24-22(13-29-25)18(14-37-24)11-26(35)36/h4-6,9-10,12-13,18,23H,7-8,11,14H2,1-3H3,(H,29,30)(H,35,36)/t18-,23+/m0/s1
PDB

Reactome pathway

UniProtKB/SwissProt

antibodypedia
GoogleScholar
UniChem
US Patent
n/an/an/an/a 378n/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
IP1 accumulation measurements using the IPOne assay systemó1321N1 cells stably expressing human GPR40 receptor (Euroscreen, Belgium) are seeded 24 h ...


US Patent US10550127 (2020)


BindingDB Entry DOI: 10.7270/Q2WW7M33
More data for this
Ligand-Target Pair
Free fatty acid receptor 1


(Homo sapiens (Human))
BDBM431926
PNG
(US10550127, Example 12 | [(S)-6-((R)-4-{2,6-Dimeth...)
Show SMILES Cc1cc(O[C@H]2CCOC2)cc(C)c1-c1ccc(F)c2[C@@H](CCc12)Nc1cc2OC[C@@H](CC(O)=O)c2cn1
Show InChI InChI=1S/C30H31FN2O5/c1-16-9-20(38-19-7-8-36-15-19)10-17(2)29(16)21-3-5-24(31)30-22(21)4-6-25(30)33-27-12-26-23(13-32-27)18(14-37-26)11-28(34)35/h3,5,9-10,12-13,18-19,25H,4,6-8,11,14-15H2,1-2H3,(H,32,33)(H,34,35)/t18-,19+,25-/m1/s1
PDB

Reactome pathway

UniProtKB/SwissProt

antibodypedia
GoogleScholar
UniChem
US Patent
n/an/an/an/a 73n/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
IP1 accumulation measurements using the IPOne assay systemó1321N1 cells stably expressing human GPR40 receptor (Euroscreen, Belgium) are seeded 24 h ...


US Patent US10550127 (2020)


BindingDB Entry DOI: 10.7270/Q2WW7M33
More data for this
Ligand-Target Pair
Free fatty acid receptor 1


(Homo sapiens (Human))
BDBM431925
PNG
(((S)-6-{(R)-4-[2,6-Dimethyl-4-(3-methyl-oxetan-3-y...)
Show SMILES Cc1cc(OCC2(C)COC2)cc(C)c1-c1ccc(F)c2[C@@H](CCc12)Nc1cc2OC[C@@H](CC(O)=O)c2cn1
Show InChI InChI=1S/C31H33FN2O5/c1-17-8-20(39-16-31(3)14-37-15-31)9-18(2)29(17)21-4-6-24(32)30-22(21)5-7-25(30)34-27-11-26-23(12-33-27)19(13-38-26)10-28(35)36/h4,6,8-9,11-12,19,25H,5,7,10,13-16H2,1-3H3,(H,33,34)(H,35,36)/t19-,25-/m1/s1
PDB

Reactome pathway

UniProtKB/SwissProt

antibodypedia
GoogleScholar
UniChem
US Patent
n/an/an/an/a 37n/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
IP1 accumulation measurements using the IPOne assay systemó1321N1 cells stably expressing human GPR40 receptor (Euroscreen, Belgium) are seeded 24 h ...


US Patent US10550127 (2020)


BindingDB Entry DOI: 10.7270/Q2WW7M33
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%